WO2019151275A1 - Procédé d'amélioration de l'adhésivité d'une composition contenant du phosphate d'adénosine - Google Patents

Procédé d'amélioration de l'adhésivité d'une composition contenant du phosphate d'adénosine Download PDF

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WO2019151275A1
WO2019151275A1 PCT/JP2019/003053 JP2019003053W WO2019151275A1 WO 2019151275 A1 WO2019151275 A1 WO 2019151275A1 JP 2019003053 W JP2019003053 W JP 2019003053W WO 2019151275 A1 WO2019151275 A1 WO 2019151275A1
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component
composition
agent
external use
external
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PCT/JP2019/003053
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Japanese (ja)
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美代子 荻原
桃子 須磨
詩織 宮脇
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大塚製薬株式会社
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners

Definitions

  • the present application relates to a method for improving stickiness of an external composition containing adenosine phosphate and / or a salt thereof, and a composition with improved stickiness.
  • Adenosine phosphate is known to have a moisturizing effect and a whitening effect, and cosmetics containing adenosine phosphate are already on the market.
  • Cosmetics have various dosage forms such as lotion, milky lotion, cream, etc., and various prescriptions are studied so as to exhibit a feeling of use according to the purpose and target of use.
  • cream preparations intended to provide oil are desired to maintain a moist feel after use, whereas men's skin care products, acne skin products, and summer lotions provide a refreshing feel.
  • men's skin care products, acne skin products, and summer lotions provide a refreshing feel.
  • Patent Documents 1 to 3 disclose an O / W emulsion composition of adenosine phosphate.
  • An object of the present invention is to provide a method for improving stickiness of a composition containing adenosine phosphate and / or a salt thereof, and a composition with improved stickiness.
  • the present inventors have found that a highly polar oil agent, silicone oil agent, film agent, water-soluble humectant, cooling agent, or organic fine particles are blended to adenosine phosphate and It has been found that the stickiness of the composition containing the salt // is drastically improved.
  • the highly polar oil increases the duration of the refreshing feeling of the composition. And it has been found that the effect of alleviating the sticky feeling due to the refreshing feeling increases.
  • the present invention provides the following external composition.
  • Component (A) adenosine phosphoric acid and / or salt thereof; and Component (B): highly polar oil agent, silicone oil agent, film agent, water-soluble humectant, cooling agent, organic fine particles, or a mixture thereof; A composition for external use.
  • the highly polar oil is selected from bisethoxydiglycol cyclohexanedicarboxylate, diethoxyethyl succinate, isostearyl alcohol, and mixtures thereof;
  • the silicone oil is selected from highly polymerized silicones, polyether-modified silicones, alkyl-modified silicones, and mixtures thereof;
  • the coating agent is selected from pullulan, polyvinylpyrrolidone, and mixtures thereof;
  • the water-soluble humectant is biosaccharide gum-1, polymethacryloyloxyethyl phosphorylcholine, polyquaternium-51, diglycerin, polyglycerin, highly polymerized polyethylene glycol, polyoxypropylene diglyceryl ether, polyoxyethylene methyl glucoside, PEG / PPG / Polybutylene glycol-8 / 5/3 glycerin, (eicosandioic acid / tetradecanedioic acid) polyglyceryl
  • composition for external use according to any one of [1] to [3], wherein the component (B) is a highly polar oil, a silicone oil, or a mixture thereof.
  • Highly polar oil selected from component (B) selected from bisethoxydiglycol cyclohexanedicarboxylate, diethoxyethyl succinate, isostearyl alcohol, and mixtures thereof; silicone oil selected from alkyl-modified silicone; and The composition for external use according to any one of [1] to [5], which is selected from a mixture.
  • composition for external use according to any one of [1] to [7], which contains 0.01 to 10% by weight of component (A).
  • composition for external use according to any one of [1] to [8], containing 0.01 to 10% by weight of component (B).
  • composition for external use according to any one of [1] to [9], wherein the component (B) is a highly polar oil.
  • Component (C) Coolant;
  • Component (D) a solubilizer selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and mixtures thereof;
  • a solubilizer selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and mixtures thereof;
  • Component (E) pH adjuster which is an inorganic alkali;
  • Component (A) adenosine phosphoric acid and / or a salt thereof; and component (B): a highly polar oil agent, a silicone oil agent, a coating agent, a water-soluble humectant, a cooling agent, organic fine particles, or a mixture thereof;
  • component (B) a highly polar oil agent, a silicone oil agent, a coating agent, a water-soluble humectant, a cooling agent, organic fine particles, or a mixture thereof;
  • the manufacturing method of the composition for external use containing.
  • Component (D) a solubilizer selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and mixtures thereof; The method for producing an external composition according to [16] or [17], further comprising mixing. [19] The method for producing an external composition according to any one of [16] to [18], further comprising mixing a component (E): a pH adjuster that is an inorganic alkali.
  • Component (B) A composition for external use containing adenosine phosphoric acid and / or a salt thereof using a highly polar oil agent, silicone oil agent, film agent, water-soluble humectant, cooling agent, organic fine particles, or a mixture thereof. How to improve stickiness.
  • Component (B) A composition for external use containing adenosine phosphoric acid and / or a salt thereof using a highly polar oil agent, silicone oil agent, film agent, water-soluble humectant, cooling agent, organic fine particles, or a mixture thereof. How to improve stickiness.
  • component (D) polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and a mixture thereof.
  • component (E) a pH adjuster that is an inorganic alkali.
  • an external composition containing adenosine phosphate and / or a salt thereof with improved stickiness is provided.
  • the present application relates to an external composition containing component (A) adenosine phosphoric acid and / or a salt thereof, and the external composition further comprises component (B) highly polar oil agent, silicone oil agent, film agent, water-soluble humectant, and cooling agent. And organic fine particles or a mixture thereof.
  • adenosine phosphate as adenosine phosphate, adenosine monophosphate (adenosine 2 ′ monophosphate, adenosine 3 ′ monophosphate, adenosine 5 ′ monophosphate, etc.), adenosine diphosphate (adenosine 5 ′ diphosphate, etc.), Adenosine triphosphate (such as adenosine 5 ′ triphosphate), adenosine 3 ′, 5 ′ cyclic phosphate, etc.), which may be used alone or in any combination of two or more. May be.
  • the salt of adenosine phosphate is not particularly limited as long as it can be incorporated into cosmetics, external medicines or quasi drugs.
  • adenosine monophosphate salts include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts, magnesium salts and barium salts; basic amino acid salts such as arginine and lysine; Ammonium salts such as ammonium salts and tricyclohexylammonium salts; and various alkanolamine salts such as monoethanolamine salts, diethanolamine salts, triethanolamine salts, monoisopropanolamine salts, diisopropanolamine salts and triisopropanolamine it can.
  • the salt of adenosine phosphate may be used alone or in combination of two or more.
  • examples of highly polar oils include bisethoxydiglycol cyclohexanedicarboxylate, diethoxyethyl succinate, and isostearyl alcohol. These highly polar oils may be used alone or in combination of two or more. Examples of preferred highly polar oils include bisethoxydiglycol cyclohexanedicarboxylate.
  • silicone oils include highly polymerized silicones (eg, those having a kinematic viscosity of 6000 mm 2 / s or more), polyether-modified silicones (eg, bisPEG-18 methyl ether dimethylsilane), alkyl-modified silicones (eg, stearyl). Dimethicone). These silicone oils may be used alone or in combination of two or more.
  • An example of a preferred silicone oil is polyether-modified silicone (more preferably bisPEG-18 methyl ether dimethylsilane).
  • examples of the coating agent include pullulan and polyvinylpyrrolidone. These coating agents may be used alone or in combination of two or more.
  • examples of water-soluble humectants include biosaccharide gum-1, polymethacryloyloxyethyl phosphorylcholine, polyquaternium-51, diglycerin, polyglycerin, highly polymerized polyethylene glycol (for example, those having a freezing point of 40 ° C.
  • polyoxy Propylene diglyceryl ether polyoxyethylene methyl glucoside, PEG / PPG / polybutylene glycol-8 / 5/3 glycerin, (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10, lecithin hydroxide, hydrogenated lecithin, and polyoxy Ethylene sorbitan triisostearate is mentioned.
  • water-soluble humectants may be used alone or in combination of two or more.
  • cooling agent examples include menthol, menthol derivatives (for example, menthyl lactate), and peppermint oil. These cooling agents may be used alone or in combination of two or more.
  • Mentor is mentioned as an example of a preferable cooling agent.
  • examples of the organic fine particles include silica, polymethyl methacrylate, talc, and urethane. These organic fine particles may be used alone or in combination of two or more.
  • component (B) is bisethoxydiglycol cyclohexanedicarboxylate
  • component (A): component (B) 1: 0.01 to 30 (more preferably 1: 0.1 to 20, more preferably 1) : 0.5 to 3, and even more preferably 1: 1 to 2) is preferably contained in the composition.
  • the lower limit of the range of the weight ratio of the component (B) when the weight of the component (A) contained in the external composition of the present application is 1, 0.01, 0.03, 0.05, 0.1, 0.5, 0.7, and 1 are listed, and examples of the upper limit include 1.5, 2, 3, 5, 10, 20, 25, and 30. It can be indicated by a combination of the lower limit value and the upper limit value.
  • the amount of component (A) contained in the composition of the present application varies depending on the use and form of the external composition, but is usually 0.001 to 10% by weight with respect to the total weight of the external composition, for example. It can be suitably selected from the range. Preferably from 0.01 wt% to 10 wt%, more preferably from 0.1 wt% to 7 wt%, more preferably from 0.5 wt% to 5 wt%, even more preferably from 0.7 wt% to 2 wt% % Is exemplified.
  • the lower limit of the range of the amount of the component (A) contained in the external composition of the present application 0.001% by weight, 0.01% by weight, 0.1% by weight, 0.5% by weight, 0% 7% by weight, 1% by weight, and examples of the upper limit include 1% by weight, 2% by weight, 3% by weight, 5% by weight, 7% by weight, and 10% by weight.
  • the upper limit include 1% by weight, 2% by weight, 3% by weight, 5% by weight, 7% by weight, and 10% by weight.
  • the amount of the component (B) contained in the composition of the present application varies depending on the type of the component (B) used, the application and form of the external composition, etc., for example, the total weight of the external composition On the other hand, it can be appropriately selected from the range of usually 0.001 to 10% by weight. Preferably from 0.01 wt% to 10 wt%, more preferably from 0.1 wt% to 7 wt%, more preferably from 0.5 wt% to 5 wt%, even more preferably from 0.7 wt% to 2 wt% % Is exemplified.
  • the lower limit of the range of the amount of the component (B) contained in the external composition of the present application 0.001% by weight, 0.01% by weight, 0.1% by weight, 0.5% by weight, 0% 7% by weight, 1% by weight, and examples of the upper limit include 1% by weight, 2% by weight, 3% by weight, 5% by weight, 7% by weight, and 10% by weight.
  • the upper limit include 1% by weight, 2% by weight, 3% by weight, 5% by weight, 7% by weight, and 10% by weight.
  • the present application further relates to: component (A) adenosine phosphate and / or salt thereof; component (B) highly polar oil (preferably bisethoxydiglycol cyclohexanedicarboxylate); and component (C) coolant (preferably menthol);
  • component (A) adenosine phosphate and / or salt thereof component (B) highly polar oil (preferably bisethoxydiglycol cyclohexanedicarboxylate); and component (C) coolant (preferably menthol);
  • the composition for external use containing this is provided.
  • High polar oils and cooling agents can improve the stickiness of the composition for external use due to adenosine phosphate and / or its salt alone, but when used in combination, the duration of the refreshing feeling is increased.
  • the sticky feeling can be improved synergistically by the refreshing feeling.
  • cooling agent of component (C) examples are as in the cooling agent examples described above.
  • the amount of the component (C) is not limited as long as the refreshing feeling is increased and the stickiness is improved.
  • the component (B): component (C) 1: 0.0001 to 1 (preferably 1 : 0.001 to 0.5, more preferably 1: 0.005 to 0.2, still more preferably 1: 0.01 to 0.1).
  • 0.0001, 0.001, 0.005, 0 examples of the lower limit of the range of the weight ratio of the component (C) when the weight of the component (B) contained in the external composition of the present application is 1.
  • 0.01, 0.02, 0.03, and 0.04, and 0.06, 0.1, 0.2, 0.5, and 1 are given as examples of the upper limit value. It can be indicated by a combination of the lower limit value and the upper limit value.
  • the amount of the component (C) that can be contained in the composition of the present application can be appropriately selected from the range of usually 0.0001 to 1% by weight with respect to the total weight of the composition for external use.
  • the amount is preferably 0.001 to 0.5% by weight, more preferably 0.005 to 0.2% by weight, and still more preferably 0.01 to 0.1% by weight.
  • the lower limit of the range of the amount of the component (C) that can be contained in the external composition of the present application 0.0001 wt%, 0.001 wt%, 0.005 wt%, 0.01 wt%, 0.05% by weight, 0.08% by weight
  • examples of the upper limit include 0.08% by weight, 0.1% by weight, 0.2% by weight, 0.5% by weight, and 1% by weight.
  • a preferable example of the range can be indicated by a combination of the lower limit value and the upper limit value.
  • the present application further includes as component (D) polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether (eg, polyoxyethylene polyoxy) as a preferred solubilizer for a composition containing adenosine phosphate and / or a salt thereof.
  • component (D) polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether (eg, polyoxyethylene polyoxy) as a preferred solubilizer for a composition containing adenosine phosphate and / or a salt thereof.
  • polyoxyethylene polyoxypropylene alkyl ether eg, polyoxyethylene polyoxy
  • Propylene decyl tetradecyl ether Propylene decyl tetradecyl ether
  • a solubilizer is used when an organic component that is hardly soluble in water (for example, a fragrance component) is mixed with water (for example, production of a liquid agent (solubilized preparation, microemulsion preparation, etc.)).
  • a solubilizer of component (D) By using the solubilizer of component (D), a liquid preparation containing adenosine phosphate and / or a salt thereof can be provided without deteriorating stickiness.
  • the amount of the component (D) that can be contained in the external composition of the present application can be appropriately selected according to the type and total amount of the organic component contained in the external composition, but for example, with respect to the total weight of the external composition Usually, it can be appropriately selected from the range of 0.001 to 10% by weight. Preferably it is 0.01 to 8% by weight, more preferably 0.05 to 5% by weight, more preferably 0.1 to 2% by weight. Furthermore, 0.001% by weight, 0.01% by weight, 0.05% by weight, 0.1% by weight, 0% as examples of the lower limit of the range of the amount of the component (D) that can be contained in the external composition of the present application.
  • a preferable example of the range can be indicated by a combination of the lower limit value and the upper limit value.
  • the external composition of the present application may contain an inorganic alkali as a pH adjuster.
  • the stickiness of the composition can be alleviated by using an inorganic alkali.
  • the kind of inorganic alkali will not be specifically limited if it can be used as a pH adjuster of an external composition, For example, potassium hydroxide, sodium hydroxide, and its mixture are mentioned.
  • the amount of the inorganic alkali that can be contained in the external composition of the present application is not particularly limited, and an amount necessary to exhibit a pH (for example, 5.5 to 7.5) corresponding to the application of the external composition can be used. .
  • an organic alkali pH adjuster may be used as long as stickiness does not become a problem.
  • composition for external use of the present application can be prepared in various forms by combining pharmaceutically or cosmetically acceptable bases and carriers in addition to the above components.
  • pharmaceutically or cosmetically acceptable base and carrier conventionally known ones can be used.
  • the composition of the present invention may be blended with various known ingredients that are blended in an external composition applied to the skin and mucous membranes of cosmetics, external medicines and quasi drugs, if necessary. it can.
  • Such components include surfactants, pigments (dyes, pigments), fragrances, preservatives, bactericides (antibacterial agents), thickeners, antioxidants, metal sequestering agents, cooling agents, deodorants, Moisturizer, UV absorber, UV scattering agent, vitamins, plant extract, skin astringent, anti-inflammatory agent (anti-inflammatory agent), whitening agent, cell activator, vasodilator, blood circulation promoter, skin function enhancer, etc. Can be mentioned.
  • composition for external use of the present application can optionally contain tranexamic acid, water, ethanol, glycerin, BG, 1,2-pentanediol, phenoxyethanol, aminohydroxymethylpropanediol, polyphosphoric acid Na, a fragrance, and a mixture thereof.
  • the external composition of the present invention can be used as an external composition applied or sprayed on the skin.
  • the composition of the present invention can be used as an external preparation (outer preparation) for cosmetics, external medicines or external quasi drugs.
  • the form of the composition for external use of the present invention is not particularly limited as long as it can be applied to the skin.
  • it is paste, mousse, gel, liquid, emulsion, suspension, cream, ointment, etc. , Solid, sheet, aerosol, spray, and liniment.
  • cosmetics lotions; emulsions such as emollient emulsions, milky lotions, nourishing emulsions, cleansing emulsions; creams such as emollient creams, massage creams, cleansing creams, makeup creams; lip creams, etc. Can do.
  • the external composition of the present application is preferably applied to liquid preparations.
  • ⁇ Test Example 1 Components for improving stickiness Each component shown in the following table was mixed and adjusted to pH 5.5 to 7.5 using a pH adjuster (KOH or aminohydroxymethylpropanediol). And the liquid agent of each formulation example was prepared. By three panelists, each prescription example (0.5g) was applied to the face, A: Not sticky; ⁇ : Almost non-sticky; ⁇ : Slightly sticky; ⁇ : Sticky; As evaluated. The results are shown in the table below. In the table, the comparative examples and the formulation examples contained the same amounts of preservatives (phenoxyethanol and 1,2-pentanediol), chelating agent (sodium polyphosphate), and flavor.
  • preservatives phenoxyethanol and 1,2-pentanediol
  • chelating agent sodium polyphosphate
  • Sensation of coolness 5 points 4 points to feel a refreshing feeling 3 points between “feeling clearly” and “feeling” 2 points to feel refreshing 1 point between “feeling faint” and “feeling” 0 points to feel a faint refreshing feeling Don't feel
  • Each component shown in Table 8 was mixed to prepare each formulation example (pH 5.5 to 7.5). By three panelists, each prescription example (0.5g) was applied to the face, A: Not sticky; ⁇ : Almost non-sticky; ⁇ : Slightly sticky; ⁇ : Sticky; As evaluated. The results are shown in Table 9.
  • potassium hydroxide and sodium hydroxide improved the stickiness of the adenosine monophosphate-containing preparation.
  • the bisethoxydiglycol cyclohexanedicarboxylate improved the stickiness compared to the control, while the other moisturizers deteriorated the stickiness.
  • Formulation Example 53 Lotion ⁇ Manufacturing method> A water-soluble component was dissolved in purified water according to a conventional method (main phase). A water-insoluble component was added to the main phase after mixing with a surfactant to obtain a skin lotion.
  • Formulation Example 54 Cloudy lotion ⁇ Ingredient> (% by weight) Adenosine phosphate 0.5 Glycerin 1 Dipropylene glycol 4 Polyethylene glycol 20000 1 Ethanol 7 Polyoxyethylene hydrogenated castor oil 0.4 Polyoxyethylene glyceryl isostearate 0.2 Pentaerythrityl tetraethylhexanoate 0.2 pH adjuster appropriate amount preservative appropriate amount perfume appropriate amount purified water residue ⁇ production method> A water phase was prepared by dissolving water-soluble components in purified water according to a conventional method. The water-insoluble component was gradually added to the aqueous phase after heating and mixing with the surfactant to obtain a cloudy lotion.
  • Formulation Example 55 Cosmetic liquid ⁇ formulation component> (% by weight) Adenosine phosphate 1 Ascorbic acid glucoside 2 Glycerin 8 Sorbitol 2 Oligohyaluronic acid 0.1 Xanthan gum 0.2 Quince seed gum 0.1 Polyoxyethylene hydrogenated castor oil 0.3 pH adjuster Appropriate amount of preservative Appropriate amount of chelating agent Appropriate amount of antioxidant Appropriate amount of perfume Appropriate amount of purified water A water-soluble component was dissolved in purified water according to a conventional method (main phase). The water-insoluble component was added to the main phase after mixing with the surfactant to obtain a cosmetic liquid.
  • Formulation Example 56 Gel serum ⁇ Manufacturing method> After dispersing the carbomer in purified water, other water-soluble components were dissolved by heating (main phase). The water-insoluble component was mixed with a surfactant, added to the main phase, thoroughly mixed thoroughly, and degassed to obtain the desired gel cosmetic liquid.
  • Formulation Example 57 Gel emulsion ⁇ formulation component> (% by weight) Adenosine phosphate 0.5 Carboxyvinyl polymer 0.2 Acrylic acid / alkyl methacrylate copolymer 0.3 Glycerin 6 Dipropylene glycol 4 Cyclopentasiloxane 5 Dimethicone 1 Dimethiconol 0.2 Aminopropyl dimethicone 0.1 Liquid isoparaffin 2 pH adjuster Appropriate amount of preservative Appropriate amount of chelating agent Appropriate amount of antioxidant Appropriate amount of perfume Appropriate amount of purified water Dissolve the water-soluble polymer and other water-soluble components in purified water with heating to prepare an aqueous phase, disperse and mix the oil phase in which oil-soluble components are heated and dissolved with a disper, emulsify, and mix thoroughly. After deaeration, the desired gel emulsion was obtained.
  • Formulation Example 58 Scalp Lotion ⁇ Ingredients> (% by weight) Adenosine phosphate 5 Hinokitiol 1 Vitamin E acetate 0.2 Menthol 0.2 Cyclohexanedicarboxylic acid bisethoxydiglycol 1 Polyoxyethylene hydrogenated castor oil 0.5 Ethanol 60 Perfume Appropriate amount of purified water Residue ⁇ Production method> Methanol, fragrance and surfactant were dissolved in a part of ethanol, ethanol phase was prepared, and other ingredients were added to the dissolved main phase to obtain the desired scalp lotion.

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Abstract

La présente invention concerne une composition contenant du phosphate d'adénosine et/ou un sel de celui-ci, et une huile hautement polaire, un agent de revêtement, un humectant soluble dans l'eau, un agent de refroidissement et/ou des microparticules organiques.
PCT/JP2019/003053 2018-01-31 2019-01-30 Procédé d'amélioration de l'adhésivité d'une composition contenant du phosphate d'adénosine WO2019151275A1 (fr)

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JP2018-015485 2018-01-31
JP2018015485A JP2021054721A (ja) 2018-01-31 2018-01-31 アデノシンリン酸含有組成物のべたつき改善方法

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JP2021011458A (ja) * 2019-07-09 2021-02-04 株式会社ノエビア 皮膚外用剤

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JP2001288043A (ja) * 2000-03-31 2001-10-16 Shiseido Co Ltd 頭皮頭髪用組成物
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JP2007063235A (ja) * 2005-09-02 2007-03-15 Shiseido Co Ltd 外観が透明な水系皮膚外用剤およびその製造方法
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JP2001288043A (ja) * 2000-03-31 2001-10-16 Shiseido Co Ltd 頭皮頭髪用組成物
JP2004256559A (ja) * 2000-11-22 2004-09-16 Otsuka Pharmaceut Co Ltd Ｏ／ｗ型乳化組成物及びその調製方法
JP2007063235A (ja) * 2005-09-02 2007-03-15 Shiseido Co Ltd 外観が透明な水系皮膚外用剤およびその製造方法
WO2009148059A1 (fr) * 2008-06-03 2009-12-10 大塚製薬株式会社 Composition émulsifiée de type huile dans l’eau de type crème, et son procédé de production

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021011458A (ja) * 2019-07-09 2021-02-04 株式会社ノエビア 皮膚外用剤

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