Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
  • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
  • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
  • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
  • A01N31/06—Oxygen or sulfur directly attached to a cycloaliphatic ring system
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
  • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
  • A01N37/46—N-acyl derivatives
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
  • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
  • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
  • A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
  • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants

Definitions

• the present invention relates to a water-soluble gel-type insect repellent for humans.
• the aerosol type which is easy to use is mainly used, but since the pest repellent component is made into fine particles and sprayed on the skin surface, some users may feel irritation in the nasal mucosa. .
• coating unevenness may occur on the application surface and there may be a part to which no pest repellent component adheres, and a biting pest such as a mosquito sensitively senses this slight part Take blood-sucking behavior. Therefore, gel-type pest repellents are used which have no coating unevenness and are resistant to scattering of pest repellent components.
• a gel-like pest repellent composition for a human body containing a pest repellent component, a gel base and water has been developed (see, for example, Patent Document 1).
• the gel-like pest repellent composition for human bodies of Patent Document 1 contains a glycol together with a brightener as a skin adhesion indicator of a pest repellent component.
• the pest repellent for human bodies adheres not only to the arms and legs but also to the palm of the hand.
• the gel type of human pest repellent is expected to be used in the field where the hands can not be washed immediately after application, but it is inconvenient that the hand feels tacky during outdoor activities, and the user of the gel type There is a risk of hesitation in applying a pest repellent for human use.
• the gel-like pest repellent composition for human bodies of Patent Document 1 improves the visibility of the application state by the formulation of the skin adhesion indicator, and in the case where the stickiness feeling of the palm accompanying the application is considered. Absent.
• the present invention has been made in view of the above problems, and an object of the present invention is to provide a gel type pest repellant for human body which can reduce the occurrence of inconvenience due to the stickiness of the hand accompanied with application. Do.
• the characteristic constitution of the gel type pest repellent for human body according to the present invention for solving the above problems is as follows: It is a water-soluble gel-type insect repellent for humans, A gel base, a gelling agent, an insect repellent component, an ultraviolet light deterioration inhibiting component, and water;
• the pest repellent component is 2- (2-hydroxyethyl) -1-piperidinecarboxylic acid 1-methylpropyl ester, 3- (Nn-butyl-N-acetyl) aminopropionic acid ethyl ester, and p-menthane- At least one selected from the group consisting of 3,8-diols,
• the ultraviolet ray deterioration inhibiting component is to be ethylhexyl paramethoxycinnamate.
• the durability of the pest repellent efficacy is better than the diet used as a pest repellent component in conventional gel-type human pest repellent agents 2- (2 -Hydroxyethyl) -1-piperidinecarboxylic acid 1-methylpropyl ester, 3- (Nn-butyl-N-acetyl) aminopropionic acid ethyl ester, and p-menthane-3,8-diol selected from the group consisting of
• the content of the pest repellent component is preferably 3 to 20% by weight.
• the gel-type human pest repellent agent of this configuration by containing the pest repellent component in the above-mentioned range, it is possible to sufficiently maintain the pest repellent efficacy while drying in a short time after application. , Can quickly eliminate the feeling of stickiness of the palm.
• the content of the ultraviolet ray deterioration inhibiting component is preferably 0.1 to 1.0% by weight.
• the viscosity of the ultraviolet light deterioration suppressing component is alleviated and the insect pest by ultraviolet light is prevented without causing stickiness at the time of application. Deterioration of the repellent component can be sufficiently suppressed.
• the gel type pest repellent agent In the gel type pest repellent agent according to the present invention, It is preferable to further contain a dispersant for the ultraviolet light deterioration inhibiting component.
• the gel type pest repellent agent of the gel type of the present invention by containing the dispersant of the ultraviolet ray deterioration suppressing component, even when the ultraviolet ray deterioration suppressing component is oil soluble, it can be dispersed in a uniform state.
• the dispersant is preferably ethanol.
• the gel-type pest repellant for a human body of this configuration by using ethanol as a dispersant, a refreshing feeling can be given at the time of application, and the stickiness of the palm can be reduced.
• the gel type pest repellent agent according to the present invention It is preferable to further contain a humectant.
• the gel-type human pest repellent of this configuration by containing the moisturizing agent, it is prevented that the human pest repellent is excessively dried after application, and the adhesion of the pest repellent component to the skin is enhanced. At the same time, the coating can be moistened to reduce the stickiness of the palm.
• the humectant is preferably 1,3-butylene glycol and / or seaweed extract.
• the adhesion of the pest repellent component to the skin and the moist feeling at the time of application become excellent by using the above-mentioned substance as the moisturizer.
• the drying time is 10 minutes or less as measured in accordance with JIS K 5600, Part 3 Section 2.
• the drying time is adjusted to be 10 minutes or less, and therefore, the time until the human pest repellent agent is applied to the skin and then dried is sufficient. It is possible to reduce the feeling of stickiness of the palm quickly.
• the turbidity determined in accordance with the visual method of the 17th Amended Japanese Pharmacopoeia / General Test Method 2.61 Turbidity Test Method be prepared so as to be equal to or less than the turbidity comparison liquid IV.
• the turbidity determined in accordance with the visual inspection method of the turbidity test method is prepared so as to be equal to or less than the comparison liquid IV of turbidity. When applied to the skin, it does not become white and gives a fresh appearance.
• the viscosity is preferably adjusted to be 0.5 to 100 Pa ⁇ s as measured according to JIS Z 8803.
• the viscosity is adjusted to 0.5 to 100 Pa ⁇ s, so it is easy to spread on the skin, and the pest repellent component is excellent to the skin Adhesion and spreadability can be obtained.
• the viscosity measured according to JIS Z 8803 is adjusted so that the viscosity decay rate determined from the initial viscosity and the final viscosity measured after leaving for 1 week outdoors without light shielding is 10% or less Is preferred.
• the viscosity decay rate is adjusted to 10% or less, whereby stable properties are maintained from the initial stage of use to the final stage of use. It can be an excellent product.
• the gel type pest repellent agent according to the present invention is preferably used for application to the head, face or neck of a human body.
• the gel-type pest repellent agent of the gel type of the present invention is a gel type in which the pest repellent component is less likely to scatter, and the pest repellent component and the ultraviolet light deterioration inhibiting component each have relatively mild skin irritation.
• (2-hydroxyethyl) -1-piperidinecarboxylic acid 1-methylpropyl ester, 3- (Nn-butyl-N-acetyl) aminopropionic acid ethyl ester, and a group consisting of p-menthane-3,8-diol Using at least one selected from the group consisting of and ethylhexyl paramethoxycinnamate to apply not only to the arms and legs of the human body but also to the head, face, or neck that is a particularly delicate site would be suitable for
• the gel type pest repellent for human body of the present invention is a water-soluble gel type pest repellent for human body, and contains a gel base, a gelling agent, a pest repellent component, and an ultraviolet ray deterioration inhibiting component. .
• the pest repellent component which is one of the main components of the gel-type human pest repellent agent of the present invention is 2- (2-hydroxyethyl) -1-piperidinecarboxylic acid 1-methylpropyl ester [hereinafter referred to as icaridine] 3- (Nn-butyl-N-acetyl) aminopropionic acid ethyl ester [hereinafter referred to as IR 3535] or p-menthane-3,8-diol.
• icaridine 2- (2-hydroxyethyl) -1-piperidinecarboxylic acid 1-methylpropyl ester [hereinafter referred to as icaridine] 3- (Nn-butyl-N-acetyl) aminopropionic acid ethyl ester [hereinafter referred to as IR 3535] or p-menthane-3,8-diol.
• IR 3535 Nn-butyl-N-acetyl aminopropionic acid eth
• the gel type pest repellent agent of the present invention can reduce the number of times of recoating to maintain the pest repellent efficacy, compared to the conventional ones which are compounded with diet, and a short time after application.
• the content of the pest repellent component in the human pest repellent agent of the present invention is preferably 3 to 20% by weight.
• the content of the pest repellent component is in such a range, it is possible to sufficiently maintain the pest repellent efficacy, but it is possible to sufficiently shorten the time to dry after application, and the feeling of stickiness of the palm is felt Can be resolved quickly.
• the content of the pest repellent component is less than 3% by weight, the pest repellent component adhering to the skin is lost early by volatilization, and the duration of the pest repellent efficacy becomes short. Therefore, it is necessary to repaint the pest repellant for human being frequently, and the feeling of stickiness of the hand will be generated each time.
• content of a pest repellent component exceeds 20 weight%, drying after application may take time.
• the gel-type pest repellent for human use is supposed to be used outdoors during the summer when biting pests are likely to appear, but the amount of ultraviolet rays is also large in the summer outdoors. If the content of the pest repellent component is increased to prepare the pest repellent for human body on the assumption that the pest repellent component is deteriorated by ultraviolet light at the time of use, drying after application may take time. In addition, excessively increasing the content of pest repellent components is economically disadvantageous. Then, in order to suppress that a pest repellent component degrades by exposure of an ultraviolet-ray after application
• the ultraviolet ray deterioration inhibiting component used in the present invention is ethylhexyl paramethoxycinnamate. Since ethylhexyl paramethoxycinnamate is excellent in ultraviolet absorptivity, it is possible to suppress the deterioration of pest repellent components due to ultraviolet rays and improve the sustainability of repellent efficacy by being added to a human body pest repellent. Therefore, it is not necessary to excessively increase the content of the pest repellent component, and in summer use, it is possible to reduce the number of times the human pest repellent is repainted in order to maintain the pest repellent efficacy. It is possible to prevent the feeling of stickiness from occurring repeatedly on the palm of the hand.
• ethylhexyl paramethoxycinnamate is a transparent liquid, and it does not significantly impair the clarity of the human pest repellant even when it is incorporated into a human pest repellent.
• an organic compound excellent in ultraviolet absorptivity such as a benzophenone derivative such as oxybenzone or a cinnamic acid derivative, as the ultraviolet ray deterioration inhibiting component.
• inorganic powders such as titanium oxide, zinc oxide and cerium oxide which are ultraviolet light scattering agents may be appropriately blended so as not to impair the clearness of the pest repellent for humans.
• the content of the ultraviolet light deterioration inhibiting component in the pest repellant for humans of the present invention is preferably 0.1 to 1.0% by weight. If the content of the ultraviolet light deterioration inhibiting component is in such a range, the deterioration of the pest repellent component due to the ultraviolet light can be suppressed, and the sustainability of the repellent efficacy can be sufficiently maintained. As a result, the balance between the persistence of pest repellent effect and the dryness is good. When the content of the ultraviolet light deterioration inhibiting component is less than 0.1% by weight, the deterioration of the pest repellent component due to ultraviolet light can not be sufficiently suppressed, and the duration of the insect repellent efficacy becomes short.
• the human pest repellent It is necessary to repaint the human pest repellent, and a stickiness will occur each time.
• the content of the ultraviolet light deterioration inhibiting component exceeds 1.0% by weight, the insect repellent component, ethylhexyl paramethoxycinnamate, is oil-soluble and has viscosity, so that the stickiness feeling at the time of application may be strong.
• the ultraviolet deterioration-inhibiting component is added beyond the amount at which the ultraviolet light deterioration-inhibiting effect necessary for practical use can be obtained, which is economically disadvantageous.
• gel bases used in the present invention include carboxy vinyl polymers, water-soluble polymers such as polyvinyl alcohol and polyvinyl pyrrolidone, acrylic acid copolymers, acrylic acid / alkyl methacrylic acid copolymers, alkyl acrylate / diacetone acrylamide Examples thereof include acrylic acid-based polymer compounds such as copolymers, polysaccharides such as alginic acid and salts thereof, and the like. Particularly, carboxyvinyl polymers are preferable.
• These gel bases are thixotropic in an aqueous solution, and show a sufficient thickening effect in a small amount.
• the content of the gel base is preferably 0.05 to 0.5% by weight.
• the content of the gel base is in such a range, sufficient viscosity can be given to the pest repellent for humans, and excellent adhesion and spreadability of the pest repellent component to the skin can be obtained.
• the content of the gel base is less than 0.05% by weight, the viscosity of the pest repellent for humans is insufficient, and there is a possibility that it becomes difficult to handle.
• the content of the gel base exceeds 0.5% by weight, the spreadability and the skin familiarity may be deteriorated due to excessive viscosity.
• the gelling agent is one that enhances the thickening property of the gel base by adjusting the pH.
• examples of the gelling agent used in the present invention include amines such as triethanolamine and tetrahydroxypropylethylenediamine, sodium hydroxide, aminomethylpropanol and the like, with preference given to triethanolamine.
• the content of the gelling agent in the pest repellent for humans is adjusted according to the content of the gel base, and is preferably 0.01 to 0.6% by weight. If the content of the gelling agent is less than 0.01% by weight, the thickening of the gel base may not be able to be sufficiently enhanced. When the content of the gelling agent exceeds 0.6% by weight, the thickening property of the gel base may be excessively increased, and the spreadability and the skin familiarity may be deteriorated.
• a dispersant for an ultraviolet ray deterioration suppressing component in addition to the above-described components, a dispersant for an ultraviolet ray deterioration suppressing component, a moisturizer, an aromatic component and the like may be appropriately blended.
• the dispersant for the ultraviolet light deterioration inhibiting component include alcohols such as ethanol and isopropanol, and ethanol is particularly preferable.
• the content of the dispersant is preferably 10 to 50% by weight. If the content of the dispersing agent is in such a range, oil-soluble ethylhexyl paramethoxycinnamate can be dispersed in a uniform state in a pest repellent for humans, and a refreshing feeling at the time of application can also be imparted. . If the content of the dispersant is less than 10% by weight, ethylhexyl paramethoxycinnamate may not be sufficiently dispersed. If the content of the dispersant exceeds 50% by weight, the skin irritation may be intensified
• the moisturizer examples include 1,3-butylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, diethylene glycol, triethylene glycol, hexylene glycol, glycols such as benzyl glycol, seaweed extract and the like, and 1,3-butylene glycol and seaweed extract are preferred.
• the content of the humectant is preferably 0.1 to 10% by weight. If the content of the moisturizing agent is in such a range, the adhesion of the pest repellent component to the skin is enhanced and the moist feeling is imparted by preventing the pest repellent for human body from being excessively dried after application. You can also.
• the content of the humectant is less than 0.1% by weight, there is a risk that the pest repellent for human use may be excessively dried after application.
• the content of the moisturizing agent exceeds 10% by weight, it takes time to dry after application, and there is a possibility that the stickiness of the hand may not be resolved quickly.
• the fragrant ingredients orange oil, lemon oil, lavender oil, peppermint oil, eucalyptus oil, eucalyptus oil, citronella oil, lime oil, jujube oil, jasmine oil, soy sauce, green tea essential oil, limonene, ⁇ -pinene, linalool, geraniol, phenylethyl
• aroma components such as alcohol, amyl cinnamic aldehyde, cumin aldehyde and benzyl acetate, and flavor components such as green leaf alcohol called green odor and green leaf aldehyde.
• the drying property of the gel type pest repellent agent of the present invention is determined by the surface drying time (hereinafter simply referred to as "drying time") measured according to JIS K 5600, Part 3, Section 2. Preferably, it is prepared to be 10 minutes or less. If the drying time is 10 minutes or less, it is possible to sufficiently shorten the time to dry after applying the human body pest repellent to the skin, and it is possible to quickly eliminate the stickiness of the palm. When the drying time exceeds 10 minutes, it takes time to dry after coating, and there is a possibility that the stickiness of the hand can not be quickly eliminated.
• the turbidity of the gel-type pest repellant of the gel type of the present invention was determined according to the visual method of the 17th Amended Japanese Pharmacopoeia / General Test Method 2.61 Turbidity Test Method “Comparable liquid IV or less of turbidity” ( Preferably, it is prepared to be 30 NTU or less. If the turbidity is less than the turbidity of the comparison liquid IV (30 NTU or less), whitening does not occur when applied to the skin, resulting in a fresh appearance. When the turbidity exceeds 30 NTU, there is a possibility that the whiteness may occur when applied to the skin.
• the gel type pest repellent agent of the present invention is prepared so that the viscosity (hereinafter simply referred to as "viscosity") measured in accordance with JIS Z 8803 is 0.5 to 100 Pa ⁇ s. Is preferred. If the viscosity is in such a range, it is easy to spread on the skin, and excellent adhesion and spreadability of the pest repellent component to the skin can be obtained.
• the gel type pest repellent agent of the present invention has thixotropy, and the measurement value after use after application of shear stress is higher than the measurement value before use before application of shear stress. It is preferable to be prepared to be small.
• the relatively large viscosity at the time of use can be stably stored in the tube container, and the relatively small viscosity at the time of use Since it is easy to spread, and excellent adhesion and spreadability to the skin of the pest repellent component is obtained, the balance between the good preservability and the ease of spreading on use becomes excellent.
• the pest repellant for human body according to the present invention is a gel type in which the pest repellent component is less likely to scatter, and the content of the pest repellent component and the ultraviolet light deterioration inhibiting component is suppressed to the above-mentioned range. It can be used for application not only to the legs, but also to the head, face or neck, which is a particularly delicate part.
• the gel type pest repellent agent of the present invention shows a high pest repellent effect against biting pests such as mosquitoes, firewood, aphids, ticks, snails, house dust mites, bedbugs, nukaka, yamavir etc. It can be used to prevent bite damage.
• the gel-type human pest repellent agent of the present invention is prepared by dispersing a gel base in purified water, and in this liquid, icaridine, IR 3535, and / or p-menthan-3,8-diol which is a pest repellent component; It is prepared by adding a gelling agent (pH adjuster) and stirring after adding and mixing with ethylhexyl paramethoxycinnamate which is a UV deterioration inhibiting component.
• a gelling agent pH adjuster
• a dispersant such as ethanol and a humectant such as 1,3-butylene glycol are added to a liquid in which a gel base is dispersed in purified water and uniformly dissolved, and then an insect repellent component and an ultraviolet light deterioration inhibitor
• the gel-type human pest repellent agent of the present invention can be easily prepared by adding a gelling agent, even when using a low water-soluble organic compound such as ethylhexyl paramethoxycinnamate as an ultraviolet light deterioration inhibiting component.
• a low water-soluble organic compound such as ethylhexyl paramethoxycinnamate
• the gel-type pest repellant of the present invention thus obtained contains icarizine, IR3535, and / or p-menthan-3,8-diol as a pest repellent component, and thus the conventional gel-type pest for human body
• the persistence of the pest repellent effect is superior to that of Diet, which has been used as a pest repellent component in a repellent, and furthermore, the stickiness of the palm which has been spread at the time of application can be quickly eliminated.
• the user since it contains ethylhexyl paramethoxycinnamate with high ultraviolet absorbability as an ultraviolet ray deterioration inhibiting component, even if it is used in summer when the amount of ultraviolet rays is high, it suppresses that the pest repellent component is deteriorated by exposure to ultraviolet rays after application. Can improve the persistence of the repellent effect, and can prevent the need for frequent repainting. As a result, the user does not hesitate to feel the stickiness of the hand for a long time, and the inconvenience caused by the stickiness of the hand can be reduced. Therefore, the user hesitates for the gel type human pest repellent agent of the present invention. It can be used without
• the gel type pest repellent agent of the present invention (Examples 1 to 7) was prepared, and these characteristics were measured and evaluated.
• gel type pest repellents (Comparative Examples 1 to 4) which are out of the scope of the present invention were also prepared, and the characteristics were measured and evaluated in the same manner as in the examples.
• Example 1 According to the composition of Table 1, carboxyvinyl polymer (0.15 parts by weight) as a gel base is added to purified water, and this is stirred to disperse it in a dispersed state, ethanol (35 parts by weight), as a moisturizer 1,3-Butylene glycol (5 parts by weight) and seaweed extract (1 part by weight) were added and stirred until the solution became homogeneous.
• Example 2 According to the composition of Table 1, except for the addition of ethylhexyl paramethoxycinnamate (0.9 parts by weight) as an ultraviolet ray deterioration inhibiting component, the same formulation and procedure as in Example 1 are used for the human beings An agent (100 parts by weight) was obtained.
• Example 3 According to the same formulation and procedure as in Example 1, except that IR 3535 (5 parts by weight) as a pest repellent component and ethylhexyl paramethoxycinnamate (0.3 parts by weight) as an ultraviolet ray deterioration inhibiting component were added according to the composition of Table 1. The gel type pest repellent agent (100 parts by weight) of Example 3 was obtained.
• Example 4 Example 1 except that p-menthane-3,8-diol (5 parts by weight) as a pest repellent component and ethylhexyl paramethoxycinnamate (0.3 parts by weight) as an ultraviolet ray deterioration inhibiting component were added according to the composition of Table 1
• the gel-type pest repellent agent for humans (100 parts by weight) of Example 4 was obtained by the same formulation and procedure as in.
• Example 5 Gel-type human insect pest repellent for gel type of Example 5 according to the same formulation and procedure as in Example 1 except that ethylhexyl paramethoxycinnamate (0.05 parts by weight) is added as an ultraviolet ray deterioration inhibiting component according to the composition of Table 1 An agent (100 parts by weight) was obtained.
• Example 6 Gel-type human insect pest repellent for gel type of Example 6 according to the same formulation and procedure as in Example 1 except that ethylhexyl paramethoxycinnamate (2.0 parts by weight) is added as an ultraviolet ray deterioration inhibiting component according to the composition of Table 1 An agent (100 parts by weight) was obtained.
• Example 7 According to the same formulation and procedure as in Example 1 except that according to the composition of Table 1, icaridine (20 parts by weight) as a pest repellent component and ethylhexyl paramethoxycinnamate (0.3 parts by weight) as an ultraviolet ray deterioration inhibiting component were added. The gel type pest repellent agent (100 parts by weight) of Example 7 was obtained.
• Comparative Example 1 According to the composition of Table 1, carboxyvinyl polymer (0.15 parts by weight) as a gel base is added to purified water, and this is stirred to disperse it in a dispersed state, ethanol (35 parts by weight), as a moisturizer 1,3-Butylene glycol (5 parts by weight) and seaweed extract (1 part by weight) were added and stirred until the solution became homogeneous. Thereafter, in this solution, icaridine (5 parts by weight) as a pest repellent component and triethanolamine (0.15 parts by weight) as a gelling agent are added, and the solution is stirred until it becomes gelled. A gel-type human pest repellent (100 parts by weight) was obtained.
• the gel type pest repellent agent of Comparative Example 1 is a formulation which does not contain an ultraviolet ray deterioration inhibiting component.
• Comparative Example 2 According to the composition of Table 1, a carboxyvinyl polymer (0.15 parts by weight) as a gel base is added to purified water, and this is stirred into a dispersed state, and ethanol (35 parts by weight), as a moisturizer 1,3-Butylene glycol (5 parts by weight) and seaweed extract (1 part by weight) were added and stirred until the solution became homogeneous.
• the gel type pest repellent agent of Comparative Example 2 is a formulation containing a conventionally used diet, not the icaridine, IR 3535, or p-menthane-3,8-diol as a pest repellent component.
• Comparative Example 3 According to the composition of Table 1, the gel-type human pest repellent agent of Comparative Example 3 (100 parts by weight) according to the same formulation and procedure as Comparative Example 1 except that icaridine (20 parts by weight) is added as a pest repellent component. I got
• Comparative Example 4 Gel-type human pest repellent agent (100 parts by weight) of Comparative Example 4 according to the same formulation and procedure as in Comparative Example 1 except that icarizine (30 parts by weight) was added as a pest repellent component according to the composition of Table 1 I got
• the gel-type pest repellents of Examples 1 to 4, 6 and 7 have viscosity decay rates suppressed to 5% or less, and have stable properties from the beginning of use to the end of use. Since it was maintained, it was excellent in usability. In addition, no decrease in the active ingredient was observed, and it was confirmed that the repellent effect was sustained over a long period of time. Furthermore, the drying time was 11 minutes or less, and after application to the skin, it was possible to quickly eliminate the sticky feeling. With respect to the gel type pest repellent agent of Example 5, the viscosity was reduced and the active ingredient was slightly decreased, but the drying time was 11 minutes and there was no problem in practical use. The
• the viscosity decay rate was a very large value of about 90%, and stable properties could not be maintained. This is considered to be attributable to the fact that the gel molecular structure of the insect repellent for humans is deteriorated and destroyed by ultraviolet light because it does not contain ethylhexyl paramethoxycinnamate which is an ultraviolet light deterioration suppressing component. Further, in Comparative Example 1 in which ethylhexyl paramethoxycinnamate was not contained, the active ingredient was also slightly reduced, and there was a concern about the sustainability of the repellent effect. Furthermore, the drying time was longer than those of Examples 1 to 7, and after application to the skin, the stickiness could not be quickly resolved, and the usability was poor.
• the gel-type pest repellent agent of Comparative Example 3 contains 20% by weight of icarizine as a pest repellent component, but does not contain ethylhexyl paramethoxycinnamate which is an ultraviolet light deterioration inhibiting component, and therefore, the viscosity is the same as Comparative Example 1.
• the decay rate was a very large value (about 80%), and stable properties could not be maintained.
• the active ingredient is decreasing, the sustainability of the repelling effect is a concern.
• the drying time also required 14 minutes, and after application to the skin, the stickiness feeling could not be quickly resolved, and the usability was poor.
• the gel-type pest repellent agent of Comparative Example 4 contained an excessive amount (30% by weight) of icaridine as a pest repellent component, whereby a remarkable reduction of the active ingredient and a prolonged drying time were observed. Moreover, since it did not contain the ethylhexyl paramethoxycinnamate which is an ultraviolet ray deterioration suppression component, the viscosity decay rate became a very large value (about 80%) as in Comparative Example 1, and stable properties could not be maintained. .
• the gel type pest repellent for human body of the present invention can be used to prevent bite damage caused by biting pests such as mosquitoes, firewood, mosquitoes, ticks, sand flies, house dust mites, bedbugs, nukaka and yamabiru.

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• 2018
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