WO2019129024A1 - Pince pour valve - Google Patents

Pince pour valve Download PDF

Info

Publication number
WO2019129024A1
WO2019129024A1 PCT/CN2018/123750 CN2018123750W WO2019129024A1 WO 2019129024 A1 WO2019129024 A1 WO 2019129024A1 CN 2018123750 W CN2018123750 W CN 2018123750W WO 2019129024 A1 WO2019129024 A1 WO 2019129024A1
Authority
WO
WIPO (PCT)
Prior art keywords
flap
valve
valve clip
clip
connecting member
Prior art date
Application number
PCT/CN2018/123750
Other languages
English (en)
Chinese (zh)
Inventor
张瑾
张健
马彩霞
程海波
Original Assignee
上海锦葵医疗器械股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201721872452.4U external-priority patent/CN208447660U/zh
Priority claimed from CN201711448182.9A external-priority patent/CN109965921B/zh
Application filed by 上海锦葵医疗器械股份有限公司 filed Critical 上海锦葵医疗器械股份有限公司
Priority to DE212018000386.6U priority Critical patent/DE212018000386U1/de
Publication of WO2019129024A1 publication Critical patent/WO2019129024A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/246—Devices for obstructing a leak through a native valve in a closed condition

Definitions

  • the first flap comprises a first connecting member and a first left flap, a first right flap, respectively connected to two sides of the first connecting member, the first left flap, the first a right flap can be gathered or unfolded relative to the first connector to cause the first flap to change between a first collapsed state and a first deployed state;
  • the first left flap and the second left flap are located in the third when the first flap is in the first deployed state and the second flap is in the second deployed state a left leaflet outside the valve clip and capable of clamping a mitral valve, the first right flap and the second right flap being located outside the third valve clip and capable of clamping a right leaflet of the mitral valve;
  • the first left flap and the second left flap can hold a left flap when the first flap is in the first collapsed state and the second flap is in the second collapsed state
  • the leaf, the first right flap and the second right flap can hold the right leaflet.
  • the limiting mechanism includes an inner limiting mechanism and an outer limiting mechanism, wherein the inner limiting mechanism is configured to restrict the first valve clip from sliding away from the second air clip, the outer limiting mechanism A combination for restricting sliding of the first and second valve clips away from the third valve clip.
  • the limiting mechanism includes a first protrusion and an inner limiting slot, the first protrusion is disposed on an outer side of the first connecting member, and the inner limiting slot is disposed at the The second protrusion is slidably disposed on the inner limiting slot, and both ends of the inner limiting slot are closed.
  • the limiting mechanism includes a plurality of the second raised portions and a plurality of outer limiting slots, and the plurality of the second protruding portions are spaced apart along a circumferential direction of the second connecting member.
  • the outer limiting chute is in one-to-one correspondence with the second convex portion.
  • the first flap further comprises a first left bent portion, a first right bent portion, the first left bent portion is connected to the first left flap, the first connecting member The first right bent portion is connected between the first right flap and the first connecting member, and the first left bent portion and the first right bent portion can be bent. Folding such that the first left flap and the first right flap are folded or unfolded relative to the first connector;
  • the first connecting member, the second connecting member and the third petal clip are all in a circular cylindrical shape.
  • one end of the third valve clip is provided with two notches, and the third valve clip is further provided with a receiving groove extending from the notch to the other end of the third valve clip, the notch For traversing the mitral valve, the receiving groove is for receiving the mitral valve.
  • the surface of the valve clip is coated with a fiber fabric or surface treated for endothelial tissue climbing to increase the biocompatibility of the instrument surface.
  • the materials of the first connecting member, the first left flap, the first right flap, the second connector, the second left flap and the second right flap are all implantable materials, and are selected From at least one of the following materials:
  • Metal and its alloy materials including stainless steel, cobalt-based alloys, titanium and titanium alloys, nickel-titanium alloy shape memory materials;
  • Inorganic materials including hydroxyapatite, high purity alumina ceramics
  • Non-degradable bio-inert medical polymer materials including nylon, polyester resin, polytetrafluoroethylene, ultra high molecular weight polyethylene, high density polyethylene, polymethyl methacrylate, polypropylene, polycarbonate, polyurethane , silicone, polyacrylonitrile;
  • the materials of the first connecting member, the first left flap, the first right flap, the second connector, the second left flap, and the second right flap may be selected from the group (1)-(4)
  • One or more materials selected from any one of the materials may be one or more materials selected from two or more of the materials (1) to (4).
  • the valve clip disclosed in the present invention can enter the heart through a catheter.
  • the first left flap and the second left flap can clamp the left leaflet, the first right flap and the second right flap. Capable of clamping the right leaflet to avoid blood reflux; the limiting mechanism makes the motion control more accurate, avoiding the separation of the first and second petals or the combination of the first and second petals and the third Separation situation.
  • the valve clip can also be used in medical devices such as the closure of a tricuspid valve or other tissue cavity to avoid blood or body fluid reflux.
  • FIG. 4 is a front elevational view of the valve clip of Embodiment 1 of the present invention, wherein the first annulus is in a first deployed state and the second annulus is in a second deployed state.
  • FIG. 6 is a front elevational view of the first air clip according to Embodiment 1 of the present invention, wherein the first air clip is in a first folded state.
  • FIG. 7 is a perspective view of the first air clip according to Embodiment 1 of the present invention, wherein the first air clip is in a first folded state.
  • Figure 16 is a top plan view of a third valve clip according to Embodiment 1 of the present invention.
  • valve clip 110: first flap; 111: first connector; 112: first left flap; 113: first right flap; 114: first left bend; 115: first right bend Folding portion; 116: first corner portion; 117: thorn-like structure; 120: second valve clip; 121: second connecting member; 122: second left flap; 123: second right flap; 124: second Left bent portion; 125: second right bent portion; 126: second corner portion; 130: third valve clip; 131: notch; 132: receiving groove; 140: limiting mechanism; 141: inner limiting mechanism; 1411: first raised portion; 1412: inner limit chute; 1421: second raised portion; 1422: outer limit chute
  • a valve clip 100 includes a first flap 110, a second flap 120, a third flap 130, and a stop mechanism 140.
  • the stop mechanism 140 is for restricting the first valve clip 110 from sliding away from the second valve clip 120 or for restricting the second valve clip 120 from sliding away from the third valve clip 130.
  • the limiting structure is configured to restrict the second valve clip 120 from sliding away from the third valve clip 130 to prevent the second valve clip 120 from separating from the third valve clip 130.
  • the limiting structure is used to limit the second annulus 120 from sliding away from the third annulus 130, that is to say the limiting structure is used for The combination of the first annulus 110 and the second annulus 120 is restricted from sliding away from the third annulus 130.
  • the first flap 110 further includes a first left bent portion 114 and a first right bent portion 115.
  • the first left bent portion 114 is connected between the first left flap 112 and the first connecting member 111.
  • a right bent portion 115 is connected between the first right flap 113 and the first connecting member 111, and the first left bent portion 114 and the first right bent portion 115 can be bent to make the first left flap 112
  • the first right flap 113 is gathered or unfolded relative to the first connecting member 111.
  • the first left flap 112, the first left bent portion 114, the first connecting member 111, the first right bent portion 115, and the first right flap member 113 are integrally formed.
  • the second valve clip 120 further includes a second left bent portion 124 and a second right bent portion 125.
  • the second left bent portion 124 is connected between the second left flap 122 and the second connecting member 121.
  • the second right bent portion 125 is connected between the second right flap 123 and the second connecting member 121.
  • the second left bent portion 124 and the second right bent portion 125 can be bent to make the second left flap 122
  • the second right flap 123 is gathered or unfolded relative to the second connecting member 121.
  • the second left flap clamp 122, the second left bent portion 124, the second connecting member 121, the second right bent portion 125, and the second right flap member 123 are integrally formed.
  • the second left flap 122 and the second right flap 123 are preferably both rotated by 60° about the second connector 121. 80°, most preferably 70° about the second connector 121. To better fit the mitral valve.
  • a side of the first left flap 112 facing the second left flap 122 is provided with a convex thorn structure 117.
  • a side of the first right flap 113 facing the second right flap 123 is provided with a convex thorn structure 117.
  • the thorn-like structure 117 is advantageous for better gripping the left and right leaflets of the mitral valve without causing necrosis of the leaflet cells.
  • first end portion and the second end portion are preferably provided with rounded corners or chamfers, that is, the first corner portion and the second corner portion are preferably rounded portions or chamfered portions.
  • all of the right angle transitions in the valve clip 100 can be changed to rounded transitions (as on either side of the receiving slot 132) to avoid damage to internal tissue; in an alternative embodiment, the valve clip All right angle transitions in 100 can be changed to chamfer transitions.
  • the plurality of second protruding portions 1421 are spaced along the circumferential direction of the second connecting member 121, and the outer limits are limited.
  • the position chutes 1422 are in one-to-one correspondence with the second bosses 1421.
  • the plurality of second bosses 1421 are preferably evenly spaced along the circumferential direction of the second connector 121. In this embodiment, the number of the second convex portions 1421 is two.
  • valve clip in this embodiment is a heart mitral valve clip applied to the mitral valve.
  • the valve clip has a reasonable structure and a simple process.
  • the valve clip can also be used in A medical device in need of a tricuspid valve or other tissue cavity closure.
  • the limiting mechanism 140 includes a first protruding portion 1411 and an inner limiting slot 1412.
  • the inner limiting mechanism 141 includes a first protruding portion 1411 and an inner limiting slot 1412.
  • the first raised portion 1411 is disposed outside the first connecting member 111.
  • the inner limiting chute 1412 is disposed on the second cuff 120, and the inner limiting chute 1412 is closed at both ends.
  • the first boss 1411 is slidably disposed in the inner limiting slot 1412.
  • the inner limiting slot 1412 is disposed on the second connecting member 121.
  • the limiting mechanism 140 includes a plurality of first protruding portions 1411 and a plurality of inner limiting slots 1412.
  • the plurality of first convex portions 1411 are spaced apart along the circumferential direction of the first connecting member 111, and the inner limiting sliding grooves 1412 are in one-to-one correspondence with the first convex portions 1411.
  • the plurality of first raised portions 1411 are preferably evenly spaced along the circumferential direction of the first connecting member 111.
  • the number of the first convex portions 1411 is two, and only one first convex portion 1411 is shown in FIG. 18; the first connecting member 111 is rotated by 180°, and the other first is further provided. The raised part is obscured in the picture.

Abstract

L'invention concerne une pince pour valve, comprenant : une première pince pour valve possédant une première pince pour valve gauche et une première pince pour valve droite, qui sont symétriques l'une par rapport à l'autre ; une deuxième pince pour valve possédant une seconde pince pour valve gauche et une seconde pince pour valve droite, qui sont symétriques l'une par rapport à l'autre, et manchonnées de façon coulissante sur la première pince pour valve ; une troisième pince pour valve emmanchée de façon coulissante sur la deuxième pince pour valve ; et un mécanisme de limitation pour empêcher que la première pince pour valve ne s'éloigne par coulissement de la deuxième pince pour valve ou empêcher que la combinaison de la première pince pour valve et de la deuxième pince pour valve ne s'éloigne par coulissement de la troisième pince pour valve. La pince pour valve peut entrer dans le cœur par l'intermédiaire d'un cathéter. Pour une valve bicuspide qui ne peut pas être fermée normalement, les première et deuxième pinces pour valve gauche peuvent serrer un feuillet de valve gauche, les première et deuxième pinces pour valve droite peuvent serrer un feuillet de valve droit, et la combinaison des première et deuxième pinces pour valve est glissée dans la troisième pince pour valve pour éviter le reflux sanguin. Le mécanisme de limitation rend plus précise la commande de mouvement et évite la séparation de la première pince pour valve et de la deuxième pince pour valve, ou la séparation de la combinaison des première et deuxième pinces pour valve de la troisième pince pour valve. La pince pour valve peut également être utilisée dans des dispositifs médicaux où la valve tricuspide ou une autre cavité tissulaire doit être fermée.
PCT/CN2018/123750 2017-12-27 2018-12-26 Pince pour valve WO2019129024A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE212018000386.6U DE212018000386U1 (de) 2017-12-27 2018-12-26 Ventilklemme

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201721872452.4 2017-12-27
CN201711448182.9 2017-12-27
CN201721872452.4U CN208447660U (zh) 2017-12-27 2017-12-27 心脏二尖瓣夹
CN201711448182.9A CN109965921B (zh) 2017-12-27 2017-12-27 心脏二尖瓣夹

Publications (1)

Publication Number Publication Date
WO2019129024A1 true WO2019129024A1 (fr) 2019-07-04

Family

ID=67063188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/123750 WO2019129024A1 (fr) 2017-12-27 2018-12-26 Pince pour valve

Country Status (2)

Country Link
DE (1) DE212018000386U1 (fr)
WO (1) WO2019129024A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021011531A1 (fr) * 2019-07-15 2021-01-21 Evalve, Inc. Clip large à ailes non déformables

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000023380A1 (it) * 2020-10-05 2022-04-05 Star Tric S R L Protesi articolata per valvola tricuspide o mitrale e relativo dispositivo di afferraggio
EP4122425A1 (fr) * 2021-07-23 2023-01-25 The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin Dispositif de fixation pour implantation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020013571A1 (en) * 1999-04-09 2002-01-31 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
CN106175986A (zh) * 2016-07-26 2016-12-07 复旦大学附属中山医院 一种瓣膜夹合器
CN206403892U (zh) * 2016-08-31 2017-08-15 常州锦葵医疗器械有限公司 二尖瓣夹

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020013571A1 (en) * 1999-04-09 2002-01-31 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
CN106175986A (zh) * 2016-07-26 2016-12-07 复旦大学附属中山医院 一种瓣膜夹合器
CN206403892U (zh) * 2016-08-31 2017-08-15 常州锦葵医疗器械有限公司 二尖瓣夹

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021011531A1 (fr) * 2019-07-15 2021-01-21 Evalve, Inc. Clip large à ailes non déformables

Also Published As

Publication number Publication date
DE212018000386U1 (de) 2020-07-29

Similar Documents

Publication Publication Date Title
JP6629956B2 (ja) 弁膜留め具
WO2021018250A1 (fr) Serre-valve doté d'une membrane et système de serrage de valve
JP6761120B2 (ja) 弁膜留め具
US10123872B2 (en) Expandable annuloplasty ring and associated ring holder
US8216304B2 (en) Annuloplasty ring and holder combination
US10568740B2 (en) Device and method to plicate the tricuspid valve
WO2019129024A1 (fr) Pince pour valve
CN107789017B (zh) 二尖瓣夹
US7575595B2 (en) Annuloplasty ring and holder combination
JP6204905B2 (ja) 心臓弁修復のための装置および方法
ES2379338T3 (es) Reparación de la válvula mitral y la válvula tricúspide
WO2018077144A1 (fr) Prothèse de valvule cardiaque fixée à travers un septum interventriculaire et son procédé de transport et de libération
EP2693986B1 (fr) Modèles de dimensionnement de l'annulus de valves cardiaques compressibles
US20050240202A1 (en) Devices and methods of repairing cardiac valves
WO2021195823A1 (fr) Agrafe de valvule cardiaque
CN111867486A (zh) 组织抓取装置和相关方法
WO2019184649A1 (fr) Système de réparation de valvule cardiaque et son dispositif de blocage de suture
CN104939949A (zh) 人造腱索
CN111671547A (zh) 具有覆膜的瓣膜夹合器及瓣膜夹合系统
BR112018013106B1 (pt) Dispositivo de implantação para uma prótese de reparo de tecido mole
WO2023045326A1 (fr) Dispositif de valvule mitrale implantable par transcathéter
CN208808747U (zh) 一种瓣膜夹合器
CN113038907A (zh) 储存装置、装载装置、递送系统、套件、以及相关方法
CN109965921B (zh) 心脏二尖瓣夹
CN113616388B (zh) 一种用于夹心脏瓣膜生物组织的夹子

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18893513

Country of ref document: EP

Kind code of ref document: A1

122 Ep: pct application non-entry in european phase

Ref document number: 18893513

Country of ref document: EP

Kind code of ref document: A1