WO2019075704A1

WO2019075704A1 - Sample analysis system, and sample analysis system control method

Info

Publication number: WO2019075704A1
Application number: PCT/CN2017/106940
Authority: WO
Inventors: 张军伟; 李学荣; 颜昌银; 赵许克
Original assignee: 深圳迈瑞生物医疗电子股份有限公司
Priority date: 2017-10-19
Filing date: 2017-10-19
Publication date: 2019-04-25
Also published as: CN110892269A; CN110892269B

Abstract

A sample analysis system, and a sample analysis system control method. The sample analysis system comprises a sample transfer device, a first sample analyzer (20), and a second sample analyzer (30). The sample transfer device comprises: a transmission channel (110), a first feeding channel (120), a second feeding channel (130), a first loading buffer area (140), a second loading buffer area (150), a first loading mechanism (160) and a second loading mechanism (170), wherein the transmission channel (110) is used for transmitting a sample rack (40); the first feeding channel (120), the second feeding channel (130), the first loading buffer area (140) and the second loading buffer area (150) are respectively arranged corresponding to the first sample analyzer (20) and the second sample analyzer (30); the first loading mechanism (160) is used for transporting the sample rack (40), which is stored in the first loading buffer area (140), to the first feeding channel (120) or the transmission channel (110); and the second loading mechanism (170) is used for transporting the sample rack (40) to the second loading buffer area (150) for storage or transporting the sample rack (40) to the second feeding channel (130).

Description

Sample analysis system and sample analysis system control method

Technical field

The invention relates to a medical diagnostic device, in particular to a sample analysis system and a sample analysis system control method.

Background technique

In the field of medical diagnosis, the sample analysis equipment is used to detect samples such as blood. The samples are generally placed on the sample rack and transported through the assembly line to realize the flow detection operation. By cascading multiple analytical instruments through a pipeline, unified management and scheduling of all samples can be performed to achieve efficient sample measurements.

Pipelined sample analysis equipment typically has separate sample centering platforms and recycling platforms that may be placed on either side or on the same side of the pipeline. The placement platform is located on one side of the pipeline. When the user places the sample holder, it can actively identify and start scheduling, and distribute the sample rack to each instrument through the external rail transmission mechanism for analysis and measurement. The front side of the instrument also has a separate loading buffer area. When the instrument receives the sample rack dispatched by the platform, it will temporarily store the sample rack and wait for the instrument to be idle before starting analysis and measurement. Such a sample analysis device increases the total length and floor space of the assembly line due to the need to provide an independent centralized placement platform on the assembly line, thereby increasing the manufacturing cost of the device.

Summary of the invention

Based on this, it is necessary to provide a sample analysis system and a sample analysis system control method for eliminating the problem of the existing pipeline sample analysis system, eliminating the independent sample placement platform, reducing the cost, and reducing the footprint.

The above objectives are achieved by the following technical solutions:

A sample analysis system comprising a sample transfer device, a first sample analyzer and a second sample analyzer,

The sample transfer device includes:

a transport channel for transporting a sample rack in which the sample container is placed, the first sample analyzer and the second sample analyzer being arranged along a transport direction of the transport channel;

a first feed channel and a second feed channel, the first feed channel and the second feed channel respectively corresponding to the first sample analyzer and the second sample analyzer, and disposed on the Between the transmission channel and the corresponding first sample analyzer or second sample analyzer;

a first loading buffer area and a second loading buffer area, wherein the first loading buffer area and the second loading buffer area are respectively disposed corresponding to the first sample analyzer and the second sample analyzer, and are located Between the transmission channel and the corresponding feed channel; and

a first loading mechanism and a second loading mechanism, wherein the first loading mechanism is configured to transport the sample racks stored in the first loading buffer to the first feeding channel and the transmission channel respectively; The loading mechanism is configured to transport the sample rack in the transport channel to the second loading buffer for storage, or to transport the sample rack stored in the second loading buffer to the second feeding channel.

The invention also provides a sample analysis system control method, comprising the following steps:

The first loading buffer corresponding to the first sample analyzer receives the sample holder containing the sample to be detected;

a first loading mechanism transporting the sample holder from a first loading buffer to a first feeding channel corresponding to the first sample analyzer, the first feeding channel transporting the sample holder to the Sampling analysis in the first sample analyzer;

The first loading mechanism transports the sample holder from the first loading buffer to the delivery channel, and the second loading mechanism transports the sample holder in the transmission channel to the second sample analyzer for sampling analysis.

The beneficial effects of the invention are:

The sample analysis system of the present invention sets a first loading mechanism capable of bidirectional loading in the first loading buffer corresponding to the first sample analyzer, so that the operator can centrally place the sample rack to be detected in the first loading buffer area, A loading mechanism dispatches the sample rack, and the sample rack can be transported to the first feeding channel corresponding to the first sample analyzer, sampled and analyzed by the first sample analyzer, and the sample rack can also be transported to the transport channel. The second loading mechanism is used to transport the sample holder on the conveying channel to the second feeding channel corresponding to the second sample analyzer, and is performed by the second sample analyzer. Sampling analysis. The sample analyzer system of the present invention eliminates the centralized placement of the platform, which reduces the system cost and reduces the footprint of the system.

DRAWINGS

1 is a schematic structural view of a first embodiment of a sample analysis system of the present invention;

2 is a schematic structural view of a second embodiment of a sample analysis system of the present invention;

3 is a schematic structural view of a third embodiment of a sample analysis system of the present invention;

4 is a schematic structural view of a fourth embodiment of a sample analysis system of the present invention;

Figure 5 is a schematic structural view of a fifth embodiment of the sample analysis system of the present invention;

6 is a schematic structural view of a sixth embodiment of a sample analysis system of the present invention;

Figure 7 is a schematic structural view of a seventh embodiment of the sample analysis system of the present invention;

8 is a schematic structural view of an eighth embodiment of a sample analysis system according to the present invention;

9a to 9g are schematic structural views of a ninth embodiment of a sample analysis system of the present invention;

10 is a schematic structural view of an embodiment of a first loading mechanism in a sample analysis system of the present invention;

Figure 11 is a perspective view of the sample transfer device in the sample analysis system of the present invention.

Figure 12 is a perspective view of a first sample holder (slim bottle) used in the sample analysis system of the present invention;

Figure 13 is a perspective view of a second sample holder (micro tube) used in the sample analysis system of the present invention;

14 is a schematic structural view of a first loading in-position detector, a first direction recognizing mechanism, a second loading in-position detector, and a second direction recognizing mechanism in the sample analyzing system of the present invention;

15 is a schematic view showing the design of a station when the first loading mechanism performs bidirectional loading in the sample analysis system of the present invention;

Figure 16 is a plan view showing another embodiment of the sample transfer device in the sample analysis system of the present invention;

Figure 17 is a perspective view of an embodiment of a manual sample introduction device in the sample analysis system of the present invention.

Detailed ways

In order to make the objects, the technical solutions and the advantages of the present invention more comprehensible, the present invention will be further described in detail by the accompanying drawings. It should be understood that the specifics described herein The examples are only intended to illustrate the invention and are not intended to limit the invention.

Example 1

As shown in FIG. 1, a first embodiment of the sample analysis system of the present invention includes a sample transfer device, a first sample analyzer 20, and a second sample analyzer 30. The sample transfer device includes a transfer channel 110, a first feed channel 120, a second feed channel 130, a first load buffer area 140, a second load buffer area 150, a first loading mechanism 160, and a second loading mechanism 170.

The transport channel 110 is for transmitting the sample rack 40 on which the sample container is placed, and the first sample analyzer 20 and the second sample analyzer 30 are sequentially arranged along the transport direction of the transport channel 110. The first feed channel 120 corresponds to the first sample analyzer 20, the second feed channel 130 corresponds to the second sample analyzer 30, and the first feed channel 120 is disposed on the transmission channel 110 and the first sample analysis Between the meters 20, a second feed channel 130 is disposed between the transfer channel 110 and the second sample analyzer 30.

The first loading buffer area 140 is disposed corresponding to the first sample analyzer 20, the second loading buffer area 150 is correspondingly disposed with the second sample analyzer 30, and the first loading buffer area 140 and the second loading buffer area 150 are respectively located in the transmission channel. 110 is between the corresponding feed channel. The first loading mechanism 160 is configured to transport the sample rack 40 stored in the first loading buffer area 140 to the first feeding channel 120 and the transmission channel 110 respectively; the second loading mechanism 170 is configured to transport the sample holder 40 in the transmission channel 110 The second loading buffer 150 is stored, or the sample holder 40 stored in the second loading buffer 150 is transported to the second feeding channel 130.

The control method employed by the sample analysis system of the first embodiment includes the following steps:

The sample holder containing the sample to be tested is placed in the first loading buffer area 140 corresponding to the first sample analyzer 20, for example, the operator puts the sample holder into the first loading buffer area 140, or passes the automatic loading device. The sample holder is placed in the first loading zone 140.

The identification device in the first loading buffer area 140 acquires the identification information on the sample rack, and the identification information may mark the information on the sample rack in a manner convenient for the machine to read by a barcode, a two-dimensional code, a color mark, etc., and the controller according to the identification information The first loading mechanism 160 is controlled to transport the sample holder from the first loading buffer area 140 to the first feeding channel 120 or the transmission channel 110 corresponding to the first sample analyzer 20 to schedule the sample holder.

After the sample rack enters the first feed channel 120, the controller controls the first feed channel 120 to perform sampling analysis before transporting the sample rack to the first sample analyzer 20.

After the sample rack enters the transport channel 110, the controller controls the transport channel 110 to transport the sample rack to a position corresponding to the second load buffer 150 corresponding to the second sample analyzer 30, and controls the second loading mechanism 170 to sample the sample. The rack is transported from the transport channel 110 to the second loading buffer 150 for storage, and the second loading mechanism 170 is controlled to transport the sample rack stored in the second loading buffer 150 to the second feeding channel 130 corresponding to the second sample analyzer 30.

After the sample holder enters the second feed channel 130, the controller controls the second feed channel 130 to transport the sample holder to the second sample analyzer 30 for sampling analysis.

It will be appreciated that analysis by only the second sample analyzer 30 can also be performed in the present invention. For example, the sample rack can be placed directly into the second loading buffer 150 by means of automatic machine placement or manual placement by an operator, thereby performing only the sampling analysis operation of the second sample analyzer 30. That is to say, the sample holder on the second loading buffer 150 may be from the transmission channel 110 or may be a sample holder placed directly in the second loading buffer 150.

The sample analysis system and the control method thereof provided by the first embodiment use the first load buffer area 140 as a sample rack centralized placement platform of the entire sample analysis system, and the first load buffer area 140 is passed through the first loading mechanism 160 capable of bidirectional loading. The sample rack placed therein is scheduled such that the sample rack can enter the first feed channel 120 or enter the second feed channel 130 via the transport channel 110 and the second load buffer 140, respectively, through the first sample analyzer 20 or The second sample analyzer 30 performs sampling analysis. The sample analysis system of the invention does not need to additionally set a sample centralized placement platform, and has a small footprint, which is extremely suitable for use in a site with high space requirements.

Example 2

As shown in FIG. 2, the second embodiment provided by the sample analysis system of the present invention differs from the first embodiment only in that the sample transfer device further includes a first unload buffer area 180 and a first unloading. The mechanism 190, the first unloading buffer area 180 is disposed corresponding to the first sample analyzer 20, and is located between the transmission channel 110 and the first feeding channel 120, and the first unloading mechanism 190 is configured to be used in the first feeding channel 120. The sample rack is transported to the first unload buffer 180 for storage.

The control method adopted for the sample analysis system of the second embodiment differs from the first embodiment in that it further includes the following steps:

The first feed channel 120 transports the sample rack sampled and analyzed by the first sample analyzer 20 to a position corresponding to the first unload buffer area 180, and the controller controls the first unloading mechanism 190 to pass the first sample analyzer. The sample rack after the 20 sample analysis is transported from the first feed channel 120 to the first unload buffer area 180 corresponding to the first sample analyzer 20.

The sample analysis system and the control method thereof provided by the second embodiment are based on the first embodiment, and the first unloading buffer area 180 and the first unloading mechanism 190 are added to be sampled and analyzed by the first sample analyzer 20. The sample rack can be temporarily stored in the first unload buffer area 180.

Example 3

As shown in FIG. 3, the third embodiment of the present invention is different from the second embodiment in that the transmission channel 110 is sequentially connected to the first loading buffer 140 and the first unloading. The buffer area 180 and the second loading buffer area 150 are further used to transport the sample rack stored in the first unloading buffer area 180 to the transport track.

The control method employed in the sample analysis system of the third embodiment adds a control mode to the first embodiment and the second embodiment, which can be sampled and analyzed by the first sample analyzer 20. The sample rack enters the second sample analyzer 30, and the specific steps include:

The controller controls the first unloading mechanism 190 to transport the sample rack stored in the first unloading buffer area 180 and sampled and analyzed by the first sample analyzer 20 to the transport track.

The control transmission channel 110 transports the sample rack sampled and analyzed by the first sample analyzer 20 to a position corresponding to the second loading buffer 150 corresponding to the second sample analyzer 30, and controls the second loading mechanism 170 to pass. The first sample analyzer 20 samples and analyzes the sample rack from the transport channel 110 to the second loading buffer 150 for storage, and controls the second loading mechanism 170 to sample the sample rack after being sampled and analyzed by the first sample analyzer 20. The second loading buffer 150 is transported to a second feed channel 130 corresponding to the second sample analyzer 30.

After the sample rack enters the second feed channel 130, the controller controls the second feed channel 130 to transport the sample rack sampled and analyzed by the first sample analyzer 20 to the second sample analyzer 30. Sampling analysis, enabling samples in the sample rack to be sampled and analyzed in both the first sample analyzer 20 and the second sample analyzer 30; or controlling the second feed channel 130 to be sampled and analyzed by the first sample analyzer 20 The subsequent sample holder passes through the second sample analyzer 30, and only the second feed channel 130 serves as a passage.

The sample analysis system and the control method thereof provided by the third embodiment are based on the first two embodiments, and a new sample analysis control mode is added, which can cause the sample to be placed on the first sample analyzer 20 After the sampling analysis is performed, the second sample analyzer 30 is sequentially accessed through the first feed channel 120, the first unload buffer area 180, the transfer channel 110, the second load buffer area 150, and the second feed channel 130, according to It is required to perform corresponding sampling analysis work on the samples in the sample holder in the second sample analyzer 30. This control mode is particularly suitable for the case where a retest is required in the second sample analyzer 30 after the first sample analyzer 20 is sampled and analyzed, for example, both the first sample analyzer 20 and the second sample analyzer 30 are Blood cell analyzer; and the case where the same sample requires different analysis items in two sample analyzers, for example, the first sample analyzer 20 is a blood cell analyzer, and the second sample analyzer 30 is a pusher. .

Example 4

As shown in FIG. 4, a fourth embodiment provided by the sample analysis system of the present invention, the fourth embodiment is generated based on the third embodiment, and the recovery platform 200 is added on the basis of the third embodiment, and the recovery platform is provided. 200 is coupled to the second feed channel 130. The sample analysis system control method for the fourth embodiment adds a corresponding control step of controlling the second feed channel 130 to transport the sample rack sampled and analyzed by the second sample analyzer 30 to the second feed channel 130. The connected recovery platform 200 is stored; or the second feed channel 130 is controlled to transport the sample rack sampled and analyzed by the first sample analyzer 20 through the second sample analyzer 30 to the recovery platform 200 for storage, but not for the second sample analysis. In-device sampling analysis.

The sample analysis system and the control method thereof provided by the fourth embodiment can cause the sample rack sampled and analyzed by the first sample analyzer 20 and/or the second sample analyzer 30 to enter the recovery platform 200 through the second feed channel 130. It is stored in the recycling platform 200 in a centralized manner, which is convenient for the operator to collect and process.

Of course, it is also possible to set the end of the second feed channel 130 in the first and second embodiments. The recovery platform controls the second feed channel 130 to transport the sample rack sampled and analyzed by the second sample analyzer 30 or the sample rack that passes through the second sample analyzer 30 to the recycling connection with the second feed channel 130. The platform 200 is stored.

Example 5

As shown in FIG. 5, a fifth embodiment provided by the sample analysis system of the present invention, the fifth embodiment is also generated based on the third embodiment, which differs from the third embodiment only in that the sample transfer device further The second unloading buffer area 210 and the second unloading mechanism 220 are disposed corresponding to the second sample analyzer 30 and located between the transmission channel 110 and the second feeding channel 130. The second unloading mechanism 220 is disposed. The sample rack in the second feeding channel 130 is transported to the second unloading buffer 210 for storage.

The control method adopted by the sample analysis system for the fifth embodiment differs from the third embodiment in that it further includes the following steps:

The second feeding channel 130 transports the sample rack sampled and analyzed by the second sample analyzer 30 to a position corresponding to the second unloading buffer 210, and the controller controls the second unloading mechanism 220 to pass through the second sample analyzer 30. The sample rack is transported from the second feed channel 130 to a second unload buffer 210 corresponding to the second sample analyzer 30 for storage. The sample rack passing through the second sample analyzer 30 includes a sample rack sampled and analyzed by the second sample analyzer 30, and a sample rack that is not sampled and analyzed only by the second sample analyzer 30.

The sample analysis system and the control method thereof provided by the fifth embodiment are based on the third embodiment, and the second unloading buffer area 210 and the second unloading mechanism 220 are added to be sampled and analyzed by the second sample analyzer 30. The sample rack can be temporarily stored in the second unload buffer 210.

Of course, the second unloading buffer area 210 and the second unloading mechanism 220 can also be added in the first and second embodiments. The setting method and the control method are the same as those in the fifth embodiment, and details are not described herein.

Example 6

As shown in FIG. 6, a sixth embodiment is provided by the sample analysis system of the present invention. The sixth embodiment is generated based on the fifth embodiment. The recovery platform 200 is added to the fifth embodiment. The transmission channel 110 is sequentially connected to the first loading buffer area 140, the first unloading buffer area 180, the second loading buffer area 150, the second unloading buffer area 210, and the recycling platform 200. The second unloading mechanism 220 is also used for the second unloading buffer area. The sample rack stored in 210 is transported to the transport channel 110.

The sample analysis system control method of the sixth embodiment adds a corresponding control step: controlling the first unloading mechanism 190 to transport the sample rack stored in the first unloading buffer area 180 to the transport channel 110; and controlling the second unloading mechanism 220 to The sample rack stored in the unloading buffer area 210 is transported to the transport channel 110; the control transport channel 110 transports the sample rack to the recycling platform 200 connected to the transport channel 110 for storage.

The sample analysis system and the control method thereof provided by the sixth embodiment may enable the sample rack sampled and analyzed by the first sample analyzer 20 and/or the second sample analyzer 30 to enter the recovery platform 200 through the transmission channel 110, and be centrally stored. In the recycling platform 200, it is convenient for the operator to collect the processing.

It can be understood that in the present embodiment, the recovery platform 200 can also be omitted and replaced with one or more sample analyzers. A plurality of sample analyzers are connected through the transmission channel 110 to realize cascade connection of a plurality of sample analyzers. Alternatively, the sample racks of the plurality of sample analyzers are collected in the same place through the transmission channel 110 for recycling. It will also be appreciated that for the user, it is also possible to choose to remove the sample holder directly from the first unload buffer 180 or the second unload buffer 210 in order to increase efficiency.

Example 7

As shown in FIG. 7, the seventh embodiment provided by the sample analysis system of the present invention is also generated based on the fifth embodiment, which is different from the fifth embodiment in that the transmission channel 110 is bidirectional. The transmission channel 110 is connected to the first loading buffer 140, the first unloading buffer 180, the second loading buffer 150, and the second unloading buffer 210, and the second unloading mechanism 220 is further used for the second unloading buffer. The sample rack stored in 210 is transported to the transport channel 110.

The control method employed by the sample analysis system for the seventh embodiment adds a control mode that allows the sample rack sampled and analyzed by the second sample analyzer 30 to be returned to the first sample than the foregoing embodiment. In the analyzer 20, the specific steps include:

The controller controls the second unloading mechanism 220 to transport the sample rack stored in the second unloading buffer 210 and sampled and analyzed by the second sample analyzer 30 to the transport track.

The control transmission channel 110 transports the sample rack that has been sampled and analyzed by the second sample analyzer 30 to a specific position of the first loading buffer area 140, which corresponds to the first sample analyzer 20, and controls the first The loading mechanism 160 transports the sample rack sampled and analyzed by the second sample analyzer 30 from the transport channel 110 to the first loading buffer 140 for storage, and controls the first loading mechanism 160 to sample the sample after being sampled by the second sample analyzer 30. The rack is transported from the first loading buffer 140 to the first feed channel 120 corresponding to the first sample analyzer 20.

After the sample rack enters the first feed channel 120, the controller controls the first feed channel 120 to transport the sample rack sampled and analyzed by the second sample analyzer 30 to the first sample analyzer 20 for sampling analysis.

The sample analysis system and the control method thereof provided by the seventh embodiment are compared with the previous embodiments, and a new sample analysis control mode is added, which allows the sample holder to be sampled in the second sample analyzer 30. After the analysis, the second sample channel 130, the second unload buffer area 210, the transmission channel 110, the first loading buffer area 140, and the first feed channel 120 are sequentially accessed into the first sample analyzer 20, according to requirements. The first sample analyzer 20 performs corresponding sampling analysis work on the samples in the sample holder. This control mode is particularly suitable for situations where a second sample analyzer 30 needs to perform a retest in the first sample analyzer 20 after sampling analysis.

In the above seven embodiments, the two sample analyzers share the first loading buffer area 140 as a storage platform for the sample rack. Therefore, it is necessary to perform the sample rack placed in the first loading buffer area 140 between the two sample analyzers. Provisioning, so that resources can be used reasonably, improve the efficiency of detection and analysis. Specifically, the following steps are included:

Identifying the number of sample shelves in the first load buffer 140 and the second load buffer 150;

The first loading mechanism 160 transports the sample rack from the first loading buffer area 140 to the transmission channel 110 or the first feeding channel 120 according to the number of sample racks in each loading buffer area;

The transport channel 110 transports the sample rack to a position corresponding to the second load buffer 150;

The second loading mechanism 170 then transports the sample racks on the transport channel 110 to the second loading buffer 150 for storage;

When the sensor or loading mechanism in the second loading buffer 150 detects that a sample rack has entered, The second feed channel 130 and the second sample analyzer 30 are restarted for sample detection analysis.

The method for identifying the number of sample racks in the loading buffer includes the following steps:

Sensors are disposed at both ends of the loading buffer area, and the sensor forms a detection area at both ends of the loading buffer area for detecting the sample holder;

Calculate the maximum number of sample racks stored in the load buffer area based on the distance between the two detection areas;

The loading mechanism is controlled to push the sample rack in the loading buffer area to move to one end of the loading buffer area. Preferably, the sample rack can be connected to one end of the transmission channel for movement. When the sample holder enters the detection area of the sensor, the sensor sends a signal to control the loading mechanism to stop moving;

Then, the loading mechanism is controlled to push the sample rack to move to the other end of the loading buffer. When the sample rack enters the detecting area of the sensor at the other end of the loading buffer, the sensor sends a signal to control the loading mechanism to stop moving;

The number of current sample racks in the loading buffer area can be obtained according to the moving distance of the loading mechanism between the two detecting areas and the maximum storage amount of the sample rack in the loading buffer area.

After identifying the number of sample shelves in the first loading buffer 140 and the second loading buffer 150, if the number of sample shelves in the first loading buffer 140 is greater than a preset value, or the sample in the second loading buffer 150 If the number of racks is less than a threshold, or if the number of racks in the first loading buffer 140 is greater than a certain amount in the second loading buffer 150, at least a portion of the racks of the first loading buffer 140 are transported. To the second load buffer 150, the number of sample racks in the first load buffer 140 and the second load buffer 150 is matched to the sampling analysis efficiency of the first sample analyzer 20 and the second sample analyzer 30.

Example 8

The eighth embodiment provided by the present invention is generated by adding a third sample analyzer based on the fourth, fifth or sixth embodiment, as shown in FIG. 8, in the fourth embodiment. The eighth embodiment is described in detail by adding a third sample analyzer 40 as an example.

The third sample analyzer 40 is disposed between the first sample analyzer 20 and the second sample analyzer 30 along the transmission direction of the transmission channel 110. The sample transfer device further includes a third feed channel 240, a third The loading buffer area 250, the third loading mechanism 270, the third unloading buffer area 260, and the third unloading mechanism 280, the third feeding channel 240 corresponding to the third sample analyzer 40, and disposed in the transmission channel 110 and the third sample analysis The third loading buffer area 250 and the third unloading buffer area 260 are disposed corresponding to the third sample analyzer 40 and located between the transmission channel 110 and the third feeding channel 240; the third loading mechanism 270 is used The sample rack in the transport channel 110 is transported to the third loading buffer 250 for storage, or the sample rack stored in the third loading buffer 250 is transported to the third feeding channel 240; the third unloading mechanism 280 is used to The sample racks in the channel 240 are transported to the third unload buffer 260 for storage, or the sample racks stored in the third unload buffer 260 are transported to the transport track 110.

After the addition of the third sample analyzer 40, the control method employed by the sample analysis system of the eighth embodiment adds the following steps:

The first loading mechanism 260 transports the sample holder from the first loading buffer area 140 to the transport channel 110, and the transport channel 110 transports the sample rack to a position corresponding to the second loading buffer area 150 or the third loading buffer area 250;

The second loading mechanism 170 transports the sample rack from the transport channel 110 to the second loading buffer 150, and the second loading mechanism 170 transports the sample rack stored in the second loading buffer 150 to the second sample analyzer 30. a two-feed channel 130, the second feed channel 130 transports the sample rack to the second sample analyzer 30 for sampling analysis;

The third loading mechanism 270 transports the sample rack from the transport channel 110 to the third loading buffer 250, and the third loading mechanism 270 transports the sample rack stored in the third loading buffer 250 to the third sample analyzer 40. The three-feed channel 240, the third feed channel 240 carries the sample holder to the third sample analyzer 40 for sampling analysis.

The eighth embodiment provides a sample analysis system having three sample analyzers, which can be combined with different types of analyzers in practical applications, for example, the first sample analyzer 20 and the third sample analyzer 40 are blood cells. The analyzer, the second sample analyzer 30 is a pusher, and the sample analyzed by the third sample analyzer 40 can be returned to the first sample analyzer 20 for the same blood item detection, in the first sample analyzer 20 or The sample analyzed by the three sample analyzer 40 can be subjected to push film detection on the second sample analyzer 30.

Since the three sample analyzers can share the first loading buffer area 140 as a storage platform for the sample rack, it is necessary to allocate the sample racks placed in the first loading buffer area 140 between the three sample analyzers to enable resources. Reasonable use to improve the efficiency of detection and analysis. Specifically, the following steps are included:

Identifying the number of sample racks in the first load buffer 140, the second load buffer 150, and the third load buffer 250 by sensors and loading mechanisms disposed on each load buffer;

The first loading mechanism 160 transports the sample rack from the first loading buffer area 140 to the transmission channel 110 according to the number of sample racks in each loading buffer area. The transmission channel 110 is based on the second loading buffer area 150 and the third loading buffer area 250. The number of sample racks transports at least a portion of the sample racks to a position corresponding to the second load buffer area 150 or the third load buffer area 250;

Specifically, if the number of sample racks in the first loading buffer area 140 is greater than a preset value, or the number of sample racks in the third loading buffer area 250 is less than a threshold, or the number of sample racks in the first loading buffer area 140 When the number of sample shelves in the third load buffer 250 is greater than a certain amount, at least a portion of the sample shelves of the first load buffer 140 are transported to the third load buffer 250, so that the first load buffer 140 and the third load cache The number of sample racks within zone 150 matches the sampling analysis efficiencies of first sample analyzer 20 and third sample analyzer 40.

The second loading mechanism 170 and the third loading mechanism 270 then transport the sample racks on the transport channel 110 to the second loading buffer 150 and the third loading buffer 250, respectively, when the sensors or loading mechanisms in each loading buffer area. When a sample rack is detected, the corresponding feed channel, loading mechanism and sample analyzer are started for sample detection and analysis. For example, when it is detected that a sample rack is placed on the third loading buffer 250, the third sample analyzer 40 and the third feed channel 240 are activated for sample detection analysis.

It can be understood that the embodiment 8 only takes three sample analyzers as an example. In actual use, it can also be four, five, or six... The sample analyzer shares the first loading buffer 140 as a sample rack. The platform is placed in a centralized manner, and its specific structure is similar to the above, and will not be described again here.

Example 9

As shown in Figures 9a to 9g, the ninth embodiment provided by the sample analysis system of the present invention, the ninth The embodiments are generated based on the first seven embodiments, and the ninth embodiment has seven sub-implements corresponding to the first seven embodiments, which in turn correspond to FIG. 9a to FIG. 9g, and the seven sub-embodiments have one common point, namely, samples. The transfer device also includes a quick channel 230 that connects the first feed channel 120 and the second feed channel 130.

The fast channel 230 provides a new sample analysis control mode for the sample analysis system of the ninth embodiment. After the sample rack is sampled and analyzed by the first sample analyzer 20, the first feed channel 120 passes the sample holder through the fast channel. 230 is transported to the second feed channel 130; then the second feed channel 130 is controlled to transport the sample rack sampled and analyzed by the first sample analyzer 20 to the second sample analyzer 30 for sampling analysis to implement the sample rack. The sample can be sampled and analyzed in both the first sample analyzer 20 and the second sample analyzer 30; or the second feed channel 130 can be controlled to pass through the sample rack after sampling and analysis by the first sample analyzer 20 The two sample analyzer 30 only uses the second feed channel 130 as a bypass channel.

For the embodiment corresponding to Figures 9a and 9b, the need for retesting in the second sample analyzer 30, as well as the same sample need, can also be met by the fast channel 230 after the first sample analyzer 20 is sampled and analyzed. The case of different analysis projects in two sample analyzers.

For the corresponding embodiment of FIG. 9c to FIG. 9g, the first feed channel 120 and the second feed channel 130 are directly connected through the fast channel 230, and the sample rack may not need to pass through the first unload buffer area 180, the transmission channel 110, and the second. Loading the buffer area 150 eliminates the queuing process of the sample rack on the second load buffer area 150.

As an optional implementation manner, in any of the above embodiments, the first feed channel 120 and the second feed channel 130 may also adopt a two-way transport structure, that is, the first feed channel 120. Or the second feed channel 130 can return the sample rack that has been sampled and analyzed by the sample analyzer back to the sample analyzer for re-sampling analysis, and realize the operation of re-inspection in the same sample analyzer.

The nine embodiments provided above use the first loading buffer corresponding to the first sample analyzer as the sample rack storage platform of the sample analysis system, and the sample rack is placed on several samples by the first loading mechanism capable of bidirectional loading. Dispatching between analyzers. Based on the same principle, the second load can be The buffer area serves as a centralized storage platform of the sample analysis system, so that the second loading mechanism can also be loaded in both directions, and the sample holder can be transported from the second loading buffer to the second feeding channel, or the sample holder can be loaded from the second loading. The buffer area is transported into the transport channel, and the transport channel capable of bidirectional transmission can transport the sample rack to the corresponding position of the first loading buffer or the third loading buffer, so that the sample holder can also be between several sample analyzers. Make the deployment. Similarly, in the eighth embodiment, the third loading buffer may also be used as a centralized storage platform of the sample analysis system, and the third loading mechanism is further configured to transport the sample rack stored in the third loading buffer to the transmission channel. The third loading mechanism can also be loaded in both directions, and the working process is similar to that described above, and will not be described herein.

In addition, the sample analyzer system of the nine embodiments provided above has a plurality of sample analyzers. In order to save energy and reagents, after the sample analysis is completed, the analyzer enters a standby state if no new samples need to be detected. The sensor is set in the loading buffer area, and when the user places the sample holder in the corresponding loading buffer area of the analyzer, the sample analyzer automatically returns from the standby state to the state ready for detection, and the corresponding loading mechanism mounts the sample holder. Ship to the analyzer for sample detection analysis.

Whether the first loading buffer area, the second loading buffer area, or the third loading buffer area is used as a centralized storage platform, the sample rack can be placed in the corresponding loading buffer by using a manual loading method or an automatic loading device, for example, A loading robot or robot moving between several loading buffers can detect the number of sample racks in the corresponding loading buffer area by using sensors provided on the loading buffer area before placing the sample holder into the loading buffer area, and selecting the sample holder One of the least number of load buffers is used as a platform for receiving sample racks, or the number of sample racks is selected to be lower than a preset number of load buffers as a platform for receiving sample racks. Controls the autoloader to automatically place the sample holder in the selected load buffer. Of course, the sensor set on the loading buffer can monitor the number of sample racks placed in the loading buffer area in real time, or use the counter to record the number of sample racks in the loading buffer area, when the sample rack is stored in a loading buffer area. When the quantity is zero, the control auto-loading device places the sample rack in the loading buffer area. When the sensor detects that the sample rack is received in the loading buffer area, the corresponding sample analyzer is controlled to start the sampling analysis work.

As shown in FIG. 10, the first loading mechanism 160 in the sample analysis system of the present invention includes: a bracket The claw 162 and the claw driving device 163 are disposed between the first feeding passage 120 and the conveying passage 110 for supporting the first loading mechanism 160, and the claw driving device 163 is disposed on the bracket 161. The driving claw 162 drives the sample holder stored in the first loading buffer area 140 to slide toward the first feeding channel 120 or the transmission channel 110.

As shown in FIG. 11, the first loading buffer area 140 in the sample analysis system of the present invention includes a panel 141 for carrying a sample holder, and the panel 141 is provided with a long hole extending from the transmission channel 110 to the first feeding channel 120. 142. The pawl driving device 163 of the first loading mechanism 160 includes a horizontal pushing component 1631, a pawl mounting seat 1632 and a lifting assembly 1633. The horizontal pushing component 1631 is disposed on the bracket 161 and can be horizontally moved relative to the bracket 161, and the claw mounting seat The 1632 is associated with the horizontal push assembly 1631, and the horizontal push assembly 1631 can drive the pawl mount 1632 to move horizontally between the transport channel 110 and the first feed channel 120. The lifting assembly 1633 is disposed on the claw mounting seat 1632, the pushing claw 162 is disposed on the lifting assembly 1633, and the lifting assembly 1633 drives the pushing claw 162 to rise, so that the pushing claw 162 at least partially penetrates the long hole 142 on the panel 141, and the sample The bottom of the frame cooperates, and the horizontal pushing component 1631 can drive the pawl mounting seat 1632 to perform horizontal movement, thereby causing the pawl 162 to drive the sample holder to slide on the panel 141 toward the first feeding channel 120 or the transmission channel 110.

As a preferred embodiment, the horizontal pushing component 1631 may be a motor timing belt driving structure, and the motor drives the timing belt to rotate, thereby driving the claw mounting seat 1632 to perform horizontal movement. Of course, the horizontal pushing component 1631 can also be a linear motor, and the primary driving pawl mounting seat 1632 of the linear motor performs horizontal linear motion. In order to ensure stable operation of the pawl mount 1632, a linear guide 164 may be mounted on the bracket 161, and the pawl mount 1632 is slidably mounted on the linear guide 164. The lifting assembly 1633 can be selected as a lifting cylinder, and the cylinder of the lifting cylinder is fixed on the claw mounting seat 1632, and the pushing claw 162 is fixedly connected to the piston rod of the lifting cylinder, and the lifting rod 162 is driven to move up and down by controlling the piston rod of the lifting cylinder. .

In the above embodiment, the lifting assembly 1633 is configured to drive the pusher 162 toward the sample holder to interlock the pawl 162 with the sample holder. It can be understood that other forms of resisting components can be used to replace the lifting assembly for driving the claws against the sample holder, for example, the resisting assembly can be driven. The claws are close to the middle from both sides of the sample holder, so that the claws hold the sample holder from both sides of the sample holder, so that the claws are interlocked with the sample holder. When the claw mounting seat moves horizontally, the claws can drive the sample holder. Slide on the panel toward the first feed channel or the transfer channel.

Further, in order to be able to position the position of the pawl 162, a position sensor 165 is respectively disposed at two ends of the bracket 161 adjacent to the first feed channel 120 and the transmission channel 110, and the position sensor 165 can be coupled with the pawl mount 1632 or The pawl 162 cooperates to cause the system controller to obtain the position of movement of the pawl 162. Wherein the position sensor 165 is preferably an optocoupler, and an optical coupling piece is disposed on the claw mounting seat 1632. When the claw mounting seat 1632 moves closer to the first feeding channel 120 or the transmission channel 110, the optical coupling piece and the optical coupling phase are The action causes the optocoupler to emit an inductive signal so that the system controller can determine the position of the pawl 162.

Only the structure of an embodiment of the first loading mechanism 160 in the sample analysis system of the present invention has been described above. It can be understood that the first loading mechanism 160 can also be a robot structure. In fact, the first unloading mechanism 190, the second loading mechanism 170, and the second unloading mechanism 220 in the sample analysis system of the present invention may also adopt the same structure as the first loading mechanism 160.

It should be noted that the sample holder 40 has a structure that can cooperate with the claws 162. As shown in FIG. 12, the bottom of the sample holder 40 is spaced apart from the bottom groove 401, and when the claws 162 are long holes from the panel 141. When the 142 is extended upward, it can be inserted into the bottom groove 401 at the bottom of the sample holder 40, thereby driving the sample holder 40 to move synchronously. In the prior art, one side of the panel of the loading buffer area has a bent edge structure, so that one side of the sample holder is stuck in the bent side structure to prevent the sample holder from falling over during the movement. Due to the bent edge structure, the sample holder can only be pushed into the loading buffer from one side of the panel. If the sample holder is directly placed directly from above the loading buffer, one end of the sample holder will fall. In the edge structure, the sample holder is placed on the panel with one end high and one end low, and the sample holder is easily dumped when the claw pushes the sample holder. In the embodiment of the present invention, the side walls of the panel are provided with guiding side walls, and the guiding side walls have no bent side structure, and the two guiding side walls form an opening opening opening upwards, and the opening position of the opening upwards enables the sample holder to be self-supporting The lower side is directly placed on the panel, and the guiding side wall can restrain the sample holder from both ends; at the same time, since the height of the pushing claw 162 is set to abut against the bottom of the sample holder 40, it can be ensured that the sample holder is not easily dumped during the movement. Of course the pusher 162 can also be taken from the sample The front and rear sides of the bottom of the frame 40 push the sample holder 40 to slide on the panel 141. In addition, the sample analysis system of the present invention can sample and analyze the sample holder 40 carrying the elongated bottle shown in FIG. 13, and can also sample and analyze the sample holder 40 carrying the micro blood, as shown in FIG. A socket 402 capable of accommodating a microtube is disposed on the 40, and the socket 402 corresponding to each microtube on the sample holder 40 is further provided with a barcode pasting area 403.

Before the sample holder 40 shown in FIG. 12 and FIG. 13 enters the sample analyzer for sampling analysis, the sample analyzer needs to scan the barcode of the test tube on the sample holder 40 to obtain a sampling analysis task of the corresponding sample, so correspondingly on the sample holder 40 The side wall of the tube placement hole is provided with a scanning hole 404, so that the scanner can scan the barcode attached to the test tube. However, if the sample holder 40 enters the first feeding channel 120 in the opposite direction, the scanning hole 404 opened in the sample holder 40 will face away from the scanner, so that the scanner cannot scan the barcode on the test tube, then the first sample The analyzer 20 is unable to sample and analyze the samples in the sample holder 40. As shown in FIG. 15, in order to avoid the reverse entry of the sample holder 40 into the first feeding channel 120, a first loading in-position detector 121 is disposed on a side of the first feeding channel 120 facing the first loading buffer 140. A load in-position detector 121 is configured to perform direction detection on the sample rack 40 entering the first feed channel 120 from the first loading buffer area 140. When the sample rack 40 is placed in the first feed channel 120 in the forward direction, the first A loading in-position detector 121 detects that the sample holder 40 is placed in the correct direction, and the first feeding channel 120 sends the sample holder 40 into the first sample analyzer 20; otherwise, the first feeding channel 120 does not The sample rack 40 placed in the reverse direction is sent to the first sample analyzer 20, and an alarm signal is issued to alert the operator.

Further, a first direction identifying mechanism 122 is disposed on a side of the first feeding channel 120 facing the first loading buffer area 140. The first direction identifying mechanism 122 is configured to cooperate with the sample holder 40, and the correct sample holder 40 is placed in the direction. When entering the first feed channel 120 from the first loading buffer 140, the first direction identifying mechanism 122 enables the sample holder 40 to trigger the first loading into position detector 121; otherwise, the first direction identifying mechanism 122 limits the sample holder 40 to trigger A load in position detector 121 is loaded.

Specifically, as shown in FIG. 12 and FIG. 13, the bottom of the sample holder 40 is provided with a convex portion 405 on the same side as the scanning hole 404 on the sample holder 40; as shown in FIG. 15, the first direction identifying mechanism 122 is oriented. The first direction of the first loading buffer 140 is configured to identify a step, and the first direction identifies the lower step The space reserved for receiving the protrusion 405 on the sample holder 40, the first loading in position detector 121 is a micro switch disposed on the side of the first direction identification step, if the sample holder 40 is placed in the correct direction Within a loading buffer 140, the raised portion 405 and the scanning aperture 404 on the sample holder 40 are both oriented toward the first feed channel 120 and the scanner, as the sample holder 40 is transported from the first loading buffer 140 to the first feed. When the channel 120 is inside, the protrusion 405 on the sample holder 40 enters into the gap below the first direction recognition step, and the protrusion 405 triggers the micro switch, and the micro switch sends a detection signal to the system controller. The first feed channel 120 is controlled to transport the sample holder 40 to the first sample analysis for sampling analysis. If the sample holder 40 is placed in the first loading buffer 140 in the reverse direction, the raised portion 405 and the scanning hole 404 on the sample holder 40 will be facing away from the first feeding channel 120 and the scanner, when the sample holder 40 is from the first When a loading buffer 140 is transported into the first feeding channel 120, the first direction identifying step is placed on the side of the sample holder 40, and the micro switch is not triggered by the sample holder 40, the system controller does not control The first feed channel 120 carries the sample holder 40 into the first sample analyzer 20 and an alarm signal is sent to alert the operator.

As shown in FIG. 14, in order to prevent the reversely placed sample holder 40 from entering the second sample analyzer 30 through the transmission channel 110, a second direction identification mechanism 111 is provided in the transmission channel 110, and the second direction identification mechanism 111 is used for The sample holder 40 cooperates to restrict the sample holder 40 from passing through the transmission channel 110 when the wrong sample holder 40 is placed in the transmission channel 110. Specifically, the second direction identifying mechanism 111 is a second direction identifying step disposed in the transmission channel 110, and the second direction identifying step is similar to the structure of the first direction identifying step, and a sample holder 40 is reserved underneath The gap of the portion 405. The width of the transport channel 110 is substantially the same as the width of the sample holder 40. After the sample holder 40 is transported from the first loading buffer 140 to the transport channel 110, the transport channel 110 transports the sample rack 40 toward the second loading buffer 150. The raised portion 405 of the sample rack 40 disposed in the correct direction can recognize the gap below the step from the second direction; and the sample holder 40 placed in the wrong direction is blocked by the second direction identifying step, thereby causing the sample holder 40 to fail, thereby The sample holder 40 placed in the reverse direction is prevented from entering the second sample analyzer 30.

Further, an alarm sensor is disposed on one side of the second direction identifying mechanism 111. When the sample rack 40 placed in the reverse direction is blocked by the second direction identifying step, the sample rack 40 triggers an alarm sensor. The alarm sensor alerts the operator by sending an alarm to the system controller.

In addition to the specific structures of the first direction identifying mechanism and the second direction identifying mechanism provided in the above embodiments, other forms may be used to identify the direction of the sample rack, for example, using a magnetic structure for direction recognition, in the sample rack. On both sides, magnets with opposite magnetic poles are arranged, and magnets are arranged in the feeding channel and the transmission channel as direction recognition mechanisms. When the sample holder is placed in the correct direction, the magnetic poles of the sample holder facing the direction identifying mechanism are different from the magnetic poles of the direction identifying mechanism. The sample holder is adsorbed into the feeding channel or the transmission channel by the direction identifying mechanism; if the sample holder is placed in the wrong direction, the magnetic pole of the sample holder facing the direction identifying mechanism is the same as the magnetic pole of the direction identifying mechanism, and under the repulsion of the magnetic force, The sample rack is pushed out of the feed channel or transport channel, and the sample rack or transport channel cannot transmit to the sample rack. The specific form that the direction identifying mechanism can adopt in the present application is not unique, and any mechanism that can identify the direction in which the sample rack is placed is within the protection scope of the present application.

As a preferred embodiment, as shown in FIG. 14, a second load in-position detector 112 is disposed on a side of the transport path 110 facing the first load buffer area 140, and the sample rack 40 is from the first load buffer area 140. When being transported into the transport channel 110, the second load in-position detector 112 detects that the sample rack 40 enters the transport channel 110, sends an in-position signal to the system controller, and controls the transport channel 110 to transport the sample rack 40. In the present embodiment, the second load-in-position detector 112 includes a micro-switch that triggers the micro-switch when the sample holder 40 enters the transmission channel 110, thereby initiating an in-position signal to the system controller. Further, the second load-in-position detector 112 further includes a rotating arm. One end of the rotating arm corresponds to the micro-switch, and the other end projects into the transmission channel 110. When the sample holder 40 enters the transmission channel 110, it will push and rotate. The arm rotates to trigger the microswitch.

The first load in-position detector 121 and the second load in-position detector 112 may use a non-contact sensor such as an optocoupler or a reed switch to detect whether the sample holder is loaded in place, in addition to the micro switch.

As shown in FIG. 15, when the first loading mechanism 160 is required to transport the sample holder in the first loading buffer 140 into the first feeding channel 120, first, the pawl is driven from the first loading buffer 140 under driving. Moving under the panel of the sample holder to the side of the sample holder away from the first feeding channel 120, pushing the claw Stopping at the end of the first loading buffer area 140 near the transmission channel 110, the position where the pawl is stopped serves as the forward loading start position of the first loading mechanism 160, and the control pawl is long from the panel at the forward loading start position. After the hole is extended, the side of the first feeding channel 120 is moved toward the side of the first feeding channel 120, and the claws push the sample holders in the first loading buffer area 140 to slide together to the first feeding channel 120 when approaching the first feeding channel 120. When a sample holder on the side enters the first feeding channel 120, the sample holder triggers the first loading in-position detector 121 in the first feeding channel 120, and the pushing claw stops the pushing action in the direction of the first feeding channel 120. Then, the pawl is lowered to the lower side of the panel and then moved to a position where the first feeding passage 120 meets the first loading buffer area 140, which is the forward loading separation position of the first loading mechanism 160, and the control pawl is loaded in the forward direction. The separation position is inserted into the bottom groove of the bottom of the sample holder adjacent to the first feeding channel 120, and then the driving claw is moved away from the side of the first feeding channel 120, so that the sample holder in the first loading buffer area 140 is moved. With the first feed channel 1 The sample holder in 20 generates a gap which forms a safety position as shown in FIG. 16. Then, the pawl is separated from the sample holder and moved to a safe position to rise above the panel. The safety position is also the first loading mechanism 160. The position where the pawl stays after each positive load is completed. The purpose of setting the safety position is based on two considerations. One is to return the claw to a fixed position after each push work, and stay above the panel so that the claw can be operated by the operator when not working. Observed position, avoiding the operator placing the sample holder above the pusher claws, causing the pusher to flip the upper sample holder when it is raised upwards; another consideration is to make the claws occupy the first one when not working The interface between the channel 120 and the first loading buffer 140 prevents the operator from placing the sample holder at the boundary between the first feeding channel 120 and the first loading buffer 140, causing the first feeding channel 120 to carry the sample. The shelf is glued to the sample holder in the first loading buffer area.

When the first loading mechanism 160 is required to transport the sample holder in the first loading buffer 140 into the transport channel 110, the working mode of the pawl is similar to that described above, and the pawl is driven from the first loading buffer. The lower side of the panel carrying the sample rack moves to the side of the sample rack away from the transport channel 110, the pawl stops at the end of the first loading buffer area 140 near the first feeding channel 120, and the position where the pawl stops is used as the first loading mechanism. a reverse loading start bit of 160, wherein the reverse loading start bit coincides with the forward load separation bit and the safety bit, and the control pawl is at the reverse loading start bit The long hole on the panel protrudes and translates to a side close to the transmission channel 110, and the claw pushes a plurality of sample holders in the first loading buffer area 140 to slide together to the transmission channel 110, and a sample holder on the side close to the transmission channel 110 When the sample holder at the foremost end of the movement direction enters the transmission channel 110, the sample holder triggers the second loading in position detector 112 in the transmission channel 110, and the pawl stops the advancement in the direction of the transmission channel 110, and then pushes the claw After falling below the panel, it moves to a position where the transmission channel 110 meets the first loading buffer area 140 as a reverse loading separation bit of the first loading mechanism 160, wherein the reverse loading separation bit and the forward loading start bit Is coincident, the control pawl is inserted into the bottom slot of the bottom of the sample rack adjacent to the transmission channel 110 at the reverse loading separation position, and then the driving claw is moved away from the side of the transmission channel 110 to make the first loading buffer The sample holder in 140 creates a gap with the sample holder in the transport channel 110, and the gap forms a separation start bit, which serves to prevent the transport channel 110 from being transported. Cause adhesion with the sample rack in a first buffer 140 when the loading of the present frame. Then, the pawl also needs to return to the illustrated safety position at the end of the push operation, which is also the position at which the pawl stays after the reverse loading of the first loading mechanism 160.

In the above various embodiments, the sample transfer device uses a combination of a transfer channel, a feed channel, a load buffer area, and an unload buffer area to form a pipeline automatic sample introduction device, and the pipeline automatic sample introduction device can transmit a large amount of flux to the sample analyzer. Automated delivery of samples, but during actual testing. However, there are still a small number of samples that need to be manually tested, such as samples without barcodes, retest samples, and trace blood samples. Therefore, in the present application, an embodiment is further provided to solve the above problem. As shown in FIG. 16, the sample transfer device in the embodiment further includes a manual sample introduction device 50, a manual sample introduction device 50 and a A sample analyzer 20 is correspondingly disposed, and the manual sample introduction device 50 is disposed between the transfer rail 110 and the corresponding first feed channel 120 for manually conveying the manually loaded sample container to the first sample analyzer 20. Sampling area. The sampling mechanism of the first sample analyzer 20 may perform sampling operation on the sample container automatically conveyed in the first feeding channel 120 in the automatic sampling area F, or may perform sampling operation on the manually loaded sample container in the manual sampling area S. The sample container manually loaded may be a sample container without a bar code, and the sample container for re-inspection or a sample container for holding a small amount of blood.

As shown in Figure 17, the manual sample introduction device 50 includes a sample compartment 51 and a translation mechanism 52, a sample compartment 51 is provided with a receiving cavity for accommodating the sample container, the translation mechanism 52 includes a sample compartment mounting base 5206 and a driving assembly, the sample compartment 51 is mounted on the sample compartment mounting base 5206, and the driving end of the driving component is connected to the sample compartment mounting base 5206 The horizontal movement of the sample compartment mounting base 5206 is driven to drive the sample compartment 51 to move horizontally between the sample container manual loading position and the manual sampling area S of the sample analyzer. The manual loading position of the sample container is set on the side away from the sample analyzer 20, which is convenient for the operator to take the sample container.

In this embodiment, at least one of the first sample analyzer 20 and the second sample analyzer 30 is capable of detecting at least at least one of blood routine, CRP, saccharification, push, blood coagulation, blood type, erythrocyte sedimentation rate, and flow project. Two items enable one tube sample to measure multiple service parameters through one sampling, which greatly shortens the detection time and improves the detection efficiency.

As a preferred embodiment, at least one of the first sample analyzer 20 or the second sample analyzer 30 is provided with a display screen, so that the operator can conveniently obtain the operating state of the system from the display screen. Control commands can be entered into the system via a touch screen display.

It should also be noted that the second sample analyzer 30, the second feed channel 130, the second loading buffer 150, the second unloading buffer 210, the second loading mechanism 170, and the first in the sample analysis system of the present invention. The two unloading mechanisms 220 may also be multiple sets, arranged in sequence along the transport track to form a sample analysis system having a plurality of sample analyzers, and the sample rack 40 is scheduled by the first loading buffer 140 and the first loading mechanism 160.

The above embodiments are merely illustrative of several embodiments of the present invention, and are not to be construed as limiting the scope of the invention. It should be noted that a number of variations and modifications may be made by those skilled in the art without departing from the spirit and scope of the invention. Therefore, the scope of the invention should be determined by the appended claims.

Claims

A sample analysis system, comprising: a sample transfer device, a first sample analyzer, and a second sample analyzer,

The sample transfer device includes:

a transport channel for transporting a sample rack in which the sample container is placed, the first sample analyzer and the second sample analyzer being arranged along a transport direction of the transport channel;

a first feed channel and a second feed channel, the first feed channel and the second feed channel respectively corresponding to the first sample analyzer and the second sample analyzer, and disposed on the Between the transmission channel and the corresponding first sample analyzer or second sample analyzer;

a first loading buffer area and a second loading buffer area, wherein the first loading buffer area and the second loading buffer area are respectively disposed corresponding to the first sample analyzer and the second sample analyzer, and are located Between the transmission channel and the corresponding feed channel; and

a first loading mechanism and a second loading mechanism, wherein the first loading mechanism is configured to transport the sample racks stored in the first loading buffer to the first feeding channel and the transmission channel respectively; The loading mechanism is configured to transport the sample rack in the transport channel to the second loading buffer for storage, or to transport the sample rack stored in the second loading buffer to the second feeding channel.
The sample analysis system according to claim 1, wherein the sample transfer device further comprises a first unload buffer and a first unloading mechanism, the first unload buffer corresponding to the first sample analyzer And disposed between the transmission channel and the first feeding channel, the first unloading mechanism is configured to transport the sample rack in the first feeding channel to the first unloading buffer area for storage.
The sample analysis system according to claim 1 or 2, wherein the transmission channel connects the first load buffer area, the first unload buffer area, and the second load buffer area, the first The unloading mechanism is further configured to transport the sample rack stored in the first unloading buffer to the transport track.
The sample analysis system according to any one of claims 1 to 3, wherein the sample transfer device further comprises a recovery platform, the recovery platform being coupled to the second feed channel.
The sample analysis system according to any one of claims 1 to 4, wherein the sample transfer device further comprises a second unloading buffer area and a second unloading mechanism, the second unloading buffer area and the second a sample analyzer correspondingly disposed between the transfer channel and the second feed channel, the second unloading mechanism configured to transport the sample rack in the second feed channel to the second unloading The cache area is stored.
The sample analysis system according to any one of claims 1 to 5, wherein the sample transfer device further comprises a recovery platform, the transfer channel connecting the first load buffer area, the first unload buffer area The second loading buffer, the second unloading buffer, and the recycling platform, the second unloading mechanism is further configured to transport the sample rack stored in the second unloading buffer to the transmission channel.
The sample analysis system according to any one of claims 1 to 6, wherein the transmission channel is a bidirectional transmission channel, and the transmission channel is connected to the first loading buffer area, the first unloading buffer area, The second loading buffer and the second unloading buffer, the second unloading mechanism is further configured to transport the sample rack stored in the second unloading buffer to the transmission channel.
The sample analysis system according to any one of claims 1 to 7, wherein said transmission channel is connected to said first load buffer area, said first unload buffer area, said second load buffer area, and said The second unload buffer is described.
The sample analysis system according to any one of claims 1 to 8, wherein the sample analyzer further comprises a third sample analyzer, the third sample analyzer being disposed along a transmission direction of the transmission channel Between the first sample analyzer and the second sample analyzer;

The sample transfer device further includes a third feed channel, a third load buffer, a third loading mechanism, a third unloading buffer, and a third unloading mechanism, the third feed channel and the third sample analyzer Correspondingly, and disposed between the transmission channel and the third sample analyzer; the third loading buffer area and the third unloading buffer area are correspondingly set with the third sample analyzer, and are located at the Between the transmission channel and the third feeding channel; the third loading mechanism is configured to transport the sample rack in the transmission channel to the third loading buffer, or to store the third loading buffer The stored sample rack is transported to the third feed channel; the third unloading mechanism is configured to use the third The sample rack in the feed channel is transported to the third unloading buffer for storage, or the sample rack stored in the third unloading buffer is transported to the transport track.
The sample analysis system according to any one of claims 1 to 9, wherein the third loading mechanism is further configured to transport the sample rack stored in the third loading buffer to the transmission channel.
The sample analysis system according to any one of claims 1 to 10, wherein the sample transfer device further comprises a fast channel connecting the first feed channel and the second feed channel .
The sample analysis system according to any one of claims 1 to 11, wherein the transmission channel is a bidirectional transmission channel, and the second loading mechanism is configured to separately store the sample racks stored in the second loading buffer area. Shipping to the second feed channel and the transfer channel.
The sample analysis system according to any one of claims 1 to 12, wherein the first loading mechanism comprises:

a bracket for supporting the first loading mechanism;

a pushing claw for sliding the sample holder stored in the first loading buffer area toward the first feeding channel or the transmission channel;

A pawl driving device is disposed on the bracket for driving the pawl to perform the above motion process.
The sample analysis system according to any one of claims 1 to 13, wherein the claw driving device comprises:

a horizontal pushing component disposed on the bracket;

a pawl mount coupled to the horizontal push assembly, the horizontal push assembly capable of driving the pawl mount to perform horizontal movement between the transfer passage and the first feed passage;

a resisting component disposed on the claw mounting seat;

The abutting assembly can drive the claw to approach the sample holder to interlock the claw with the sample holder, and the horizontal pushing assembly can drive the claw mounting seat to perform horizontal movement, thereby Pushing the claw to drive the sample holder on the panel toward the first feed channel or the The transmission channel slides.
The sample analysis system according to any one of claims 1 to 14, wherein the first loading buffer area comprises a panel for carrying a sample holder, and the panel is open to extend from the transmission channel to the An elongated hole of the first feeding passage, the abutting assembly is a lifting assembly disposed on the claw mounting seat,

Wherein, the lifting component drives the claw to rise, so that the pawl at least partially penetrates the long hole and cooperates with the bottom of the sample holder.
The sample analysis system according to any one of claims 1 to 15, wherein the first loading buffer area comprises a panel for carrying a sample holder, and two sides of the panel are respectively provided with guiding side walls, two The guiding side wall forms an opening opening upwardly, and the placing opening enables the sample holder to be placed on the panel from top to bottom.
The sample analysis system according to any one of claims 1 to 16, wherein the first feed channel is provided with a first load in-position detector toward a side of the first load buffer.
The sample analysis system according to any one of claims 1 to 17, wherein a first direction identification mechanism is disposed on a side of the first feed channel toward the first load buffer area, the first The direction identifying mechanism is configured to cooperate with the sample holder, and the first direction identifying mechanism enables the sample holder to trigger the first stage when the correct sample holder is placed in the direction from the first loading buffer to the first feeding channel A loading in position detector; otherwise, the first direction identifying mechanism limits the sample holder to trigger the first load in position detector.
The sample analysis system according to any one of claims 1 to 18, wherein a second direction identifying mechanism is disposed in the transmission channel, and the second direction identifying mechanism is configured to cooperate with the sample holder when placed in the direction The second direction identifying mechanism is configured to restrict the sample holder from passing through the transmission channel when an erroneous sample holder enters the transmission channel.
The sample analysis system according to any one of claims 1 to 19, characterized in that the second direction identification means is provided with an alarm sensor on one side.
The sample analysis system according to any one of claims 1 to 20, wherein the transfer path is disposed with a second load in-position detector toward a side of the first load buffer.
The sample analysis system according to any one of claims 1 to 21, wherein the sample transfer device further comprises at least one manual sample introduction device, and one of the manual sample introduction devices is set corresponding to one of the sample analyzers. The manual sampling device is disposed between the transport track and a corresponding feed channel for transporting the manually loaded sample container to a corresponding manual sampling area of the sample analyzer.
The sample analysis system according to any one of claims 1 to 22, wherein the manual sample introduction device comprises:

a sample compartment, the sample compartment being provided with a receiving cavity for accommodating the sample container;

a translating mechanism comprising a sample compartment mounting base and a driving assembly, the sample compartment being mounted on the sample compartment mounting base, the driving end of the driving component being coupled to the sample compartment mounting base to drive the The sample compartment mounting base moves for moving the sample compartment between a sample container manual loading position and a manual sampling area of the sample analyzer.
The sample analysis system according to any one of claims 1 to 23, wherein at least one of the first sample analyzer and the second sample analyzer is capable of detecting blood routine, CRP, and saccharification At least two of push, clotting, blood type, erythrocyte sedimentation, and flow projects.
The sample analysis system according to any one of claims 1 to 24, wherein a display screen is provided on at least one of the first sample analyzer or the second sample analyzer.
A sample analysis system control method, comprising the steps of:

The first loading buffer corresponding to the first sample analyzer receives the sample holder containing the sample to be detected;

a first loading mechanism transporting the sample holder from a first loading buffer to a first feeding channel corresponding to the first sample analyzer, the first feeding channel transporting the sample holder to the Sampling analysis in the first sample analyzer;

a first loading mechanism transports the sample holder from a first loading buffer to a transport channel, and a second loading mechanism transports the sample holder in the transmission channel to a second feeding channel corresponding to the second sample analyzer The second feed channel transports the sample holder to a second sample analyzer for picking Sample analysis.
The sample analysis system control method according to claim 26, wherein said transfer path transports said sample holder to a position corresponding to a second load buffer area, said second load buffer area and said second Corresponding to the sample analyzer, the second loading mechanism transports the sample holder from the transport channel to the second loading buffer, and the second loading mechanism stores the sample stored in the second loading buffer The rack is transported to a second feed channel corresponding to the second sample analyzer, and the second feed channel transports the sample rack to the second sample analyzer for sampling analysis.
The sample analysis system control method according to claim 26 or 27, wherein the first unloading mechanism transports the sample rack sampled and analyzed by the first sample analyzer from the first feed channel to The first unloading buffer area corresponding to the first sample analyzer is stored.
The sample analysis system control method according to any one of claims 26 to 28, wherein the second unloading mechanism transports the sample holder passing the second sample analyzer from the second feed channel to the first The second unloading buffer area corresponding to the two sample analyzers is stored.
The sample analysis system control method according to any one of claims 26 to 29, wherein the first unloading mechanism transports the sample rack stored in the first unloading buffer area to the transmission channel;

The second unloading mechanism transports the sample rack stored in the second unloading buffer area to the transmission channel;

The transport channel transports the sample rack to a recycling platform connected to the transport channel for storage.
The sample analysis system control method according to any one of claims 26 to 30, wherein the second unloading mechanism stores the sample rack after sampling and analyzing by the second sample analyzer stored in the second unloading buffer area. Transported to the transport track;

Transmitting the sample rack to a specific position of the first loading buffer, the specific position corresponding to the first sample analyzer, the first loading mechanism locating the sample holder The transmission channel is transported to the first sample analyzer for sampling analysis.
A sample analysis system control method according to any one of claims 26 to 31, The first unloading mechanism transports the sample rack stored in the first unloading buffer area and sampled and analyzed by the first sample analyzer to the transport track;

The second loading mechanism transports the sample rack sampled and analyzed by the first sample analyzer from the transport channel to a second feed channel corresponding to the second sample analyzer, the second feed Passing the sample holder to the second sample analyzer for sampling analysis; or the second feeding channel passes the sample holder after sampling analysis by the first sample analyzer A second sample analyzer, and the second sample analyzer does not sample.
The sample analysis system control method according to any one of claims 26 to 32, wherein the second feed channel transports the sample rack sampled and analyzed by the second sample analyzer to a host Depositing a storage platform connected to the second feed channel; the second feed channel transports the sample rack that passes through the second sample analyzer and is not sampled to be connected to the second feed channel Recycling platform storage.
The sample analysis system control method according to any one of claims 26 to 33, wherein the number of sample racks in the first load buffer area and/or the second load buffer area is identified, according to samples in each load buffer area The number of racks transports at least a portion of the sample rack of the first load buffer to the second load buffer.
The sample analysis system control method according to any one of claims 26 to 34, further comprising identifying the number of sample racks in the third load buffer area, and loading the first load according to the number of sample racks in each load buffer area. At least a portion of the sample shelves of the buffer area are transported to the second load buffer area and the third load buffer area, respectively.
The sample analysis system control method according to any one of claims 26 to 35, wherein the first loading mechanism transports the sample holder from the first loading buffer to the transmission channel, and the transmission channel takes the sample The shipping is respectively sent to a position corresponding to the second loading buffer and the third loading buffer, the second loading buffer corresponding to the second sample analyzer, the third loading buffer and the third sample Corresponding to the analyzer;

The second loading mechanism transports the sample holder from the transport channel to the second loading buffer, and the second loading mechanism transports the sample rack stored in the second loading buffer to a second feed channel corresponding to the second sample analyzer, the second feed channel transporting the sample rack to the second sample analyzer for sampling analysis;

The third loading mechanism transports the sample rack from the transport channel to the third loading buffer for storage, and the third loading mechanism transports the sample rack stored in the third loading buffer to the third sample analysis A third feed channel corresponding to the instrument, the third feed channel transporting the sample rack to the third sample analyzer for sampling analysis.
The sample analysis system control method according to any one of claims 26 to 36, wherein the first feed channel transports the sample rack sampled and analyzed by the first sample analyzer through a fast lane to The second feed channel;

Controlling the second feed channel to transport the sample rack sampled and analyzed by the first sample analyzer to the second sample analyzer for sampling analysis; or controlling the second feed channel to enable The sample holder sampled and analyzed by the first sample analyzer passes through the second sample analyzer.
The sample analysis system control method according to any one of claims 26 to 37, wherein the second loading buffer corresponding to the second sample analyzer receives the sample holder containing the sample to be detected;

a second loading mechanism transports the sample holder from the second loading buffer to a second feeding channel corresponding to the second sample analyzer, the second feeding channel transporting the sample holder to the first Sampling analysis in a two-sample analyzer;

The second loading mechanism transports the sample holder from the second loading buffer to the transport channel, and the first loading mechanism transports the sample rack in the transport channel to the first sample analyzer for sampling analysis.
The sample analysis system control method according to any one of claims 26 to 38, wherein the transport path transports the sample rack to a position corresponding to the first load buffer area, the first load The mechanism transports the sample rack from the transport channel to the first loading buffer, and the first loading mechanism transports the sample rack stored in the first loading buffer to correspond to the first sample analyzer a first feed channel that transports the sample holder to the first sample analyzer for sampling analysis.
The sample analysis system control method according to any one of claims 26 to 39, wherein the first load buffer area and the second load buffer area are identified to store the number of sample racks; and the sample racks are placed in the number Fewer loading buffers or load buffers below the preset number of sample racks.
The sample analysis system control method according to any one of claims 26 to 40, wherein the step of identifying the number of sample racks in each loading buffer area comprises the following steps: obtaining in accordance with detection areas at both ends of each loading buffer area The sample rack detection signal controls the loading mechanism in the loading buffer area to push the sample rack to move between the detecting areas at both ends of the loading buffer area, according to the moving distance between the two detecting areas of the loading mechanism and between the two detecting areas. The maximum number of sample racks is stored to calculate the number of racks in the load buffer area.
The sample analysis system control method according to any one of claims 26 to 41, wherein the sample rack is transported from the first loading buffer to the first sample analyzer at a first loading mechanism Before the step of the first feeding channel or the transmission channel, the identification information on the sample holder is acquired, and the first loading mechanism is controlled to transport the sample holder according to the identification information.
The sample analysis system control method according to any one of claims 26 to 42, wherein the first loading mechanism transports the sample holder from the first loading buffer to the first corresponding to the first sample analyzer The step of the feed channel or the transmission channel specifically includes the following steps: the first loading mechanism pushes the sample rack stored in the first loading buffer area toward the first feeding channel or the transmission channel, so that the sample rack located at the forefront of the moving direction Entering the first feed channel or the transfer channel; pushing the sample holder in the first loading buffer to push a gap with the sample holder entering the first feed channel or the transfer channel.
The sample analysis system control method according to any one of claims 26 to 43, wherein detecting whether a sample rack is stored in each loading buffer area, and starting a sample analyzer corresponding to a loading buffer area in which the sample rack is placed is started. Perform sampling analysis analysis.