WO2019047002A1 - 一种含有抗氧化剂的化妆品组合物 - Google Patents

一种含有抗氧化剂的化妆品组合物 Download PDF

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WO2019047002A1
WO2019047002A1 PCT/CN2017/100481 CN2017100481W WO2019047002A1 WO 2019047002 A1 WO2019047002 A1 WO 2019047002A1 CN 2017100481 W CN2017100481 W CN 2017100481W WO 2019047002 A1 WO2019047002 A1 WO 2019047002A1
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Prior art keywords
curcumin
fluorophenyl
propenone
antioxidant
fluorocurcumin
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PCT/CN2017/100481
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English (en)
French (fr)
Inventor
赵文忠
洪盛杰
林学镁
谷志静
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拉芳家化股份有限公司
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Priority to CN201780004912.8A priority Critical patent/CN108697601A/zh
Priority to PCT/CN2017/100481 priority patent/WO2019047002A1/zh
Publication of WO2019047002A1 publication Critical patent/WO2019047002A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Definitions

  • the invention belongs to the field of daily chemistry, and in particular relates to a cosmetic composition containing an antioxidant.
  • antioxidants are a frequently used ingredient. In one way, it can prevent and delay the color change reaction of other active substances in cosmetics, and secondly, it can prevent oxidation and rancidity of the oil used.
  • Antioxidants that are often used such as butylated hydroxytoluene BHT, butylated hydroxyanisole BHA, alpha tocopherol or alpha tocopherol acetate such as vitamin E, ascorbic acid and its derivatives are also called vitamin C, etc.
  • these antioxidants are large Partly used to prevent oxidation and rancidity of cosmetic base materials, play a role in preserving freshness, and the combination of vitamin E and vitamin C has a synergistic effect on skin whitening.
  • curcumin Many plant-derived ingredients have strong antioxidant properties such as curcumin, ferulic acid, hesperetin, lycopene, green tea, grape seed, nicotinamide, etc. Among them, curcumin is superior to its high antioxidant properties. The traditional use of antioxidants has been widely concerned, and the application of curcumin in cosmetics has also attracted the interest of many research fields and formulators.
  • Curcumin belongs to plant polyphenols and is an orange-yellow crystalline powder extracted from fresh turmeric and turmeric volatile oil, and its structure is as shown in Formula I.
  • Curcumin also known as curcumin, has a variety of good biological activities, long-term non-toxic side effects, anti-inflammatory, anti-oxidation and other pharmacological effects, but the structure is not stable enough, easy to decompose, poor water solubility, low blood concentration, making it biological The availability is low, the stability is poor, the color is heavier, and it is difficult to use in cosmetics.
  • Tetrahydrocurcumin is a kind of skin care product which is commonly used for whitening, freckle and anti-oxidation by dehydrogenation of curcumin isolated from the roots of curcuma longa.
  • curcumin structure has not affected people's research. According to the structural characteristics of curcumin, the synthesis of new curcumin derivatives or analogues, exploring its physical properties and biological activity, has become a hot topic in recent research. Numerous studies have shown that numerous curcumin derivatives or analogs have stronger biological activity than curcumin.
  • a cosmetic composition containing an antioxidant, in addition to a cosmetically acceptable carrier: an emulsifier, a UV absorber, a thickener, a polyol, a chelating agent, a preservative, a fragrance, and In addition to ionized water, it contains:
  • curcumin in an amount of 0.05-0.6% by weight of the composition
  • a curcumin analog comprising 0.05 to 1.0% by weight of the composition, the curcumin analog being fluorocurcumin.
  • the technical solution of the present invention comprises: the curcumin is tetrahydrocurcumin.
  • the technical solution of the present invention comprises: the fluorine-containing curcumin is 1-(4-fluorophenyl)-3-(2-fluorophenyl)-propenone, 1-(4-fluorophenyl)-3-( a mixture of 3-fluorophenyl)-propenone and 1-(4-fluorophenyl)-3-(4-fluorophenyl)-propenone, and the weight ratio of the three mixtures is 1-(4-fluorophenyl) -3-(2-fluorophenyl)-propenone: 1-(4-fluorophenyl)-3-(3-fluorophenyl)-propenone: 1-(4-fluorophenyl)-3-( 4-fluorophenyl)-propenone was 1:1:1.
  • a cosmetic composition containing an antioxidant the composition and content of which are:
  • curcumin and fluorinated curcumin complex contained in the present invention and conventional vitamin C Compared with the complex of ferulic acid and ferulic acid, it has more excellent anti-oxidation effect, can capture harmful oxygen free radicals, and has good synergistic effect especially in the improvement of sunscreen index of sunscreen cosmetics. It has a certain repairing effect on dry and sun damaged skin, and has a defensive effect on air pollutants such as smoke, smoke, air pollutants, free radicals and ultraviolet rays.
  • the cosmetic composition containing the antioxidant of the present invention may be presented as a gel, cream, lotion, essence, spray, oil-in-water emulsion or water-in-oil emulsion, sunscreen lotion and the like.
  • an antioxidant-containing cosmetic composition of the present invention is an antioxidant-containing sunscreen lotion, and the antioxidant component is curcumin and curcumin analog.
  • a cosmetic containing an antioxidant contains an antioxidant component as described below:
  • curcumin the present invention is tetrahydrocurcumin
  • Curcumin analogues including fluorocurcumin A1, fluorinated curcumin curcumin A2 and fluorocurcumin A3;
  • a cosmetic containing an antioxidant also contains cosmetically acceptable ingredients such as emulsifiers, oils, thickeners, preservatives and flavors.
  • Tetrahydrocurcumin tetrahydrocurcumin, hydrogenated from curcumin isolated from the roots of curcuma longa.
  • White powder content 95%, molecular weight: 372.2, CAS number: 36062-04-1. It can effectively inhibit the generation of oxygen free radicals and can remove the free radicals that have formed, and has obvious anti-oxidation effects, such as anti-human skin aging, repair, lightening pigments, ecchymoses, etc., as an antioxidant in the present invention.
  • Curcumin analogue (Fluorin-containing curcumin): Fluorinated curcumin A1 (see Formula III) is 1-(4-fluorophenyl)-3-(2-fluorophenyl)-propenone, pale yellow crystal, chemical formula : C 15 H 10 F 2 O, molecular weight 244.24. The melting range is 80.6 to 81.1 °C. Slightly soluble in water, soluble in organic solvents, stable under normal conditions.
  • Fluorinated curcumin A2 (see formula IV) Compound A2: 1-(4-fluorophenyl)-3-(3-fluorophenyl)-propenone, pale yellow crystal, chemical formula: C 15 H 10 F 2 O, The molecular weight is 244.24. The melting range is 86.4 to 87.2 °C. Slightly soluble in water, soluble in organic solvents, stable under normal conditions.
  • Fluorinated curcumin A3 (see formula V) Compound A3: 1-(4-fluorophenyl)-3-(4-fluorophenyl)-propenone, pale yellow crystal, chemical formula: C 15 H 10 F 2 O, The molecular weight is 244.24, the melting range is 108 ⁇ 109.2°C, it is slightly soluble in water, soluble in organic solvents, and stable under normal conditions.
  • Emulsifier may be an anionic, cationic, amphoteric or nonionic emulsifier.
  • Preferred anionic emulsifiers in the present invention such as phosphates such as potassium lauryl phosphate, C20-22 alcohol phosphate, may also be nonionic.
  • the nonionic emulsifier may be a glyceride such as glyceryl stearate, and may be a polyglyceride such as polyglycerol-10 stearate, polyglycerol-6 oleate, polyglycerol-3 acetate.
  • polyglycerol-4, etc. polysorbate such as: polysorbate-20, polysorbate-60, polysorbate-80, etc.; polyethers such as: cetyl stearyl alcohol Ether-25, ceteareth-6 and the like.
  • the emulsifier of the present invention is preferably polyglycerol-3-acetate and ceteareth-25, wherein polyglycerol-3-acetate and ceteareth-25 comprise 1% by weight of the cosmetic of the present invention, respectively.
  • the thickener of the present invention may be selected from the group consisting of: Kappa 934, Kappa 940, Kappa 980, polyacrylamides such as Bizik's 305 (Polyacrylamide/C13-14 isoparaffin) /Lauryl alcohol-7), etc.
  • the thickener used in the present invention is: polyacrylamide 305 (SEPPIGEL 305), 305 thickener accounts for 0.5-3.0% by weight of the invention, further optimized to 0.6-1.5%, other
  • the thickener further includes one or more of stearic acid, cetostearyl alcohol, magnesium aluminum silicate, hydroxyethyl cellulose, xanthan gum, and the like.
  • the polyol may include glycerin, 1,3 butanediol, dipropylene glycol, and preferably 1,3 butanediol of the present invention. 1,3 butanediol is 3% by weight in the cosmetic of the present invention.
  • the cosmetic of the present invention may contain more than one sunscreen or UV absorber when used as a day cream.
  • the sunscreen agent used has at least one compound having an absorption wavelength in the UVB region (absorption wavelength of 290-320 nm) and, in addition, as an optional sunscreen agent, at least one absorption wavelength in the UVA region (absorption wavelength of 320-400 nm) compound of.
  • the ultraviolet absorber used in the present invention accounts for about 2-20% by weight of the cosmetic of the present invention, and is further optimized to 10-15%, wherein butyl methoxydibenzoylmethane accounts for 0.5-2% by weight of the cosmetic of the present invention, and salicylate
  • the acid ethylhexyl ester accounts for 3-5% by weight of the cosmetic of the present invention
  • octocrylene accounts for 6-8% by weight of the cosmetic of the present invention.
  • UV absorbers such as: benzophenone 2-10%, methoxycinnamate ethylhexyl 2-10%, PAPA and hexyl ester 1-8%, benzylidene camphorsulfonate 1-6 %, p-aminobenzoic acid 1-5%, ethylhexyl triazinone 1-5%, phenyl benzimidazole sulfonic acid and its potassium, sodium and triethanolamine salt 1-8%, titanium dioxide 1-25%, oxidation Zinc 1-25% and so on.
  • Preservatives commonly used in cosmetic hygiene regulations, such as imidazolidinyl ureas, parabens such as methylparaben and propylparaben, phenoxyethanol, disodium edetate (chelating agent) Etc.
  • a suitable amount of parabens and phenoxyethanol is preferred, and the chelating agent is disodium ethylenediaminetetraacetate.
  • Example 1 In the examples, I, II, III, VI and VII are comparative examples (for experimental comparison); in addition, Example IV, Example V, Example VIII, and Example IX, Example X is the present invention. Example.
  • Comparative Example I is a basic cosmetic formulation containing no UV absorbers and cosmetically acceptable carriers, and does not contain any other antioxidant actives, four comparative examples: Comparative Example II, Comparative Example III Comparative Example VI and Comparative Example VII, based on Comparative Example I, were added with antioxidants such as vitamin C phosphate magnesium, vitamin E acetate and ferulic acid.
  • Example IV A total of five examples of the present invention are Example IV, Example V, Example VIII, Example IX, and Example X.
  • antioxidant components such as curcumin, fluorocurcumin A1, fluorocurcumin A2 and fluorocurcumin A3 were added on the basis of Comparative Example 1.
  • the cosmetic composition containing the antioxidant tests the synergistic effect of the antioxidant and the ultraviolet absorber contained in the invention, and the synergistic effect of the invention is curcumin, fluorocurcumin A1. a mixture of fluorocurcumin A2 and fluorocurcumin A3, and compared with a mixture of antioxidants such as vitamin C phosphate magnesium, vitamin E acetate heaic acid used in the comparative examples; Comparison of SPF Values of Examples and Comparative Examples The synergistic effect of the two groups of antioxidant mixtures and ultraviolet absorbers before and after judgment was judged.
  • Example I contains neither curcumin nor fluorinated curcumin complex nor conventional compound of vitamin C, vitamin E and ferulic acid, the measured SPF value (human body method) is 13.8;
  • Comparative Example II, Comparative Example III, Comparative Example VI, and Comparative Example VII all contained a complex of vitamin C, vitamin E, and ferulic acid, but did not contain the curcumin and fluoro-turmeric of the present invention.
  • the composites, the SPF values of the four comparative examples were 13.5 for Comparative Example II, 13.8 for Comparative Example III, 13.8 for Comparative Example VI, and 14 for Comparative Example VII, and further, Examples IV, Example V, Example VIII, Example IX and Example X are examples of the present invention and both contain curcumin and fluorocurcumin complex, and the measured SPF values are SPF15, SPF16, SPF16, respectively. 3. SPF17 and SPF17.
  • Example IV By comparing the above embodiments of the present invention (Example IV, Example V, Example VIII, Example IX, and Example X) with the comparative examples, it was found that the sun protection index of the embodiment of the present invention exhibits a gradient increase and the synthesis of Example IX. The effect was the best, and the sun protection index of the five comparative examples (I, II, III, VI, and VII) did not increase much.
  • the composite containing curcumin and fluorocurcumin and the cosmetic containing vitamin E, vitamin C and ferulic acid complex used in the present invention are conventionally used.
  • the cosmetic sunscreen index of the composite containing curcumin and fluorocurcumin in the present invention is higher than that of the cosmetics containing vitamin E, vitamin C and ferulic acid complex which are conventionally used.
  • the curcumin and the fluorocurcumin have more excellent antioxidant effects in the present invention, and the effect of synergistically enhancing the sunscreen index of the cosmetic (sunscreen) is used together with the organic sunscreen.
  • Example IX an antioxidant-containing cosmetic composition

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Abstract

一种含有抗氧化剂的化妆品组合物，除化妆品可接受的载体如乳化剂，紫外线吸收剂，增稠剂，多元醇，适量的螯合剂，防腐剂，香精，以及去离子水外，含有：1、占组合物重量0.05-0.6％的姜黄素；2、占组合物重量0.05-1.0％的姜黄素类似物，所述姜黄素类似物为含氟姜黄素。所含姜黄素和含氟姜黄素复合物，具有优异的抗氧化效果，能捕捉有害氧自由基，尤其在防晒化妆品防晒指数的提升方面具有良好的协同效果。对于干燥和晒后受损的皮肤具有一定的修护作用，对于空气污染物如烟雾，烟尘，空气中的污染成分，自由基和紫外线具有防御的作用。

Description

一种含有抗氧化剂的化妆品组合物 技术领域
本发明属于日化领域，具体涉及一种含有抗氧化剂的化妆品组合物。
背景技术
在化妆品技术领域，抗氧化剂是个经常被应用的成份。一来可以防止和延缓化妆品中其它活性物质的变色反应，二来能阻止所用油脂的氧化酸败等。经常被使用的抗氧剂如，丁羟甲苯BHT,丁羟茴醚BHA，阿尔法生育酚或阿尔法生育酚醋酸酯如维生素E，抗坏血酸及其衍生物也叫维生素C等等，目前这些抗氧化剂大部分用来防止化妆品基料的氧化和酸败，起到保鲜作用，维生素E和维生素C的搭配使用对皮肤美白具有协同效果。
许多植物来源的成份具有较强的抗氧化特性如：姜黄素、阿魏酸、橙皮素、番茄红素、绿茶、葡萄籽、烟酰胺等，其中姜黄素以其高强的抗氧化特性优于传统使用的抗氧化剂而被广泛关注，姜黄素在在美容化妆品中的应用也引起不少研究领域和配方工程师的兴趣。
姜黄素属于植物多酚，是一种从鲜姜黄和姜黄挥发油中提取的橙黄色结晶粉末，其结构如式Ⅰ所示。
Figure PCTCN2017100481-appb-000001
Figure PCTCN2017100481-appb-000002
姜黄素也被称为姜黄色素具有多种良好的生物活性，长期无毒副作用，具有抗炎、抗氧化等药理作用，但结构不够稳定，易分解，水溶性差，血药浓度低，使其生物可利用度较低，其稳定性差，颜色较重，在化妆品中使用有一定的难度。
四氢姜黄素是姜科植物姜黄(curcuma longa)根茎中分离出的姜黄素(curcumin)脱氢而来常用于美白、祛斑、抗氧化的各类护肤品。
姜黄素结构的稳定性并没有影响人们对其研究，根据姜黄素的结构特点，合成新的姜黄素衍生物或类似物，探究其物理化性质及生物活性，成为近期研究的热点。大量研究表明：众多姜黄素衍生物或类似物具有比姜黄素更强的生物活性。
因此有必要综合利用姜黄素及其衍生物，姜黄素类似物的抗氧化和稳定性相结合的优势。
发明内容
本发明的目的是提供一种具有较好抗氧化效果的化妆品组合物。
本发明的目的是这样实现的：一种含有抗氧化剂的化妆品组合物，除化妆品可接受的载体：乳化剂、紫外线吸收剂、增稠剂、多元醇、螯合剂、防腐剂、香精、以及去离子水外，含有：
A、占组合物重量0.05-0.6％的姜黄素；
B、占组合物重量0.05-1.0％的姜黄素类似物，所述姜黄素类似物为含氟姜黄素。
本发明的技术方案包括：所述姜黄素为四氢姜黄素。
本发明的技术方案包括：所述含氟姜黄素为1-(4-氟苯基)-3-(2-氟苯基)-丙烯酮、1-(4-氟苯基)-3-(3-氟苯基)-丙烯酮、1-(4-氟苯基)-3-(4-氟苯基)-丙烯酮的混合物，且三种混合物重量比1-(4-氟苯基)-3-(2-氟苯基)-丙烯酮:1-(4-氟苯基)-3-(3-氟苯基)-丙烯酮:1-(4-氟苯基)-3-(4-氟苯基)-丙烯酮为1:1:1。
一种含有抗氧化剂的化妆品组合物，其组分及含量为：
Figure PCTCN2017100481-appb-000003
本发明优点：本发明中所含姜黄素和含氟姜黄素复合物与常规的维生素C、 维生素E和阿魏酸的复合物相比，具有更加优异的抗氧化效果，能捕捉有害氧自由基，尤其在防晒化妆品防晒指数的提升方面具有良好的协同效果。对于干燥和晒后受损的皮肤具有一定的修护作用，对于空气污染物如烟雾、烟尘、空气中的污染成分，自由基和紫外线具有防御的作用。
具体实施方式
下面结合实施例对本发明本进一步的详细说明。
本发明一种含抗氧化剂的化妆品组合物，可以是一种凝胶、霜、乳液、精华液、喷雾、水包油乳液或油包水乳液、防晒乳液等剂型呈现。
为了阐述本发明的目的，本发明一种含抗氧化剂的化妆品组合物为一种含抗氧化剂的防晒乳液，所述抗氧化成份为姜黄素和姜黄素类似物。
一种含有抗氧化剂的化妆品含有如下所述抗氧化成份：
(1)姜黄素：本发明为四氢姜黄素；
(2)姜黄素类似物：包括含氟姜黄素A1，含氟姜黄素姜黄素A2和含氟姜黄素A3；
(3)(1)(2)的混合物。
一种含有抗氧剂的化妆品还含有化妆品可接受的成分如：乳化剂、油脂、增稠剂、防腐剂和香精。
四氢姜黄素：四氢姜黄素，由姜科植物姜黄(curcuma longa)根茎中分离出的姜黄素(curcumin)氢化而来。白色粉末，含量95％，分子量:372.2，CAS编号:36062-04-1。能有效抑制氧自由基的生成并能清除已经形成的自由基，具有明显的抗氧化作用，如抗人体皮肤衰老、修复、淡化色素、祛斑等，在本发明中作为抗氧化剂。
Figure PCTCN2017100481-appb-000004
姜黄素类似物(含氟姜黄素)：含氟姜黄素A1(见式Ⅲ)为1-(4-氟苯基)-3-(2-氟苯基)-丙烯酮，淡黄色晶体，化学式：C15H10F2O，分子量244.24。熔程80.6～81.1℃。微溶于水，可溶于有机溶剂，正常条件下稳定。
Figure PCTCN2017100481-appb-000005
含氟姜黄素A2(见式Ⅳ)化合物A2：1-(4-氟苯基)-3-(3-氟苯基)-丙烯酮，淡黄色晶体，化学式：C15H10F2O，分子量244.24。熔程86.4～87.2℃。微溶于水，可溶于有机溶剂，正常条件下稳定。
Figure PCTCN2017100481-appb-000006
含氟姜黄素A3(见式Ⅴ)化合物A3：1-(4-氟苯基)-3-(4-氟苯基)-丙烯酮，淡黄色晶体，化学式：C15H10F2O，分子量244.24，熔程108～109.2℃，微溶于水，可溶于有机溶剂，正常条件下稳定。
Figure PCTCN2017100481-appb-000007
乳化剂：乳化剂可以为阴离子，阳离子，两性以及非离子乳化剂，本发明优选阴离子类乳化剂如，磷酸酯类如月桂醇磷酸酯钾，C20-22醇磷酸酯，也可以为非离子类乳化剂。所述非离子乳化剂可以为甘油酯类如甘油硬脂酸酯，可以为聚甘油脂类如：聚甘油-10硬脂酸酯、聚甘油-6油酸酯、聚甘油-3葵酸酯、聚甘油-4葵酸酯等，聚山梨醇酯类如：聚三梨醇酯-20、聚三梨醇酯-60、聚三梨醇酯-80等；聚醚类如：鲸蜡硬脂醇聚醚-25、鲸蜡硬脂醇聚醚-6等。本发明乳化剂优选聚甘油-3葵酸酯和鲸蜡硬脂醇聚醚-25，其中聚甘油-3葵酸酯和鲸蜡硬脂醇聚醚-25分别占本发明化妆品重量1％。
增稠剂：本发明增稠剂可以选自卡波类如：卡波934、卡波940、卡波980、聚丙烯酰胺类如赛比克的305(聚丙烯酰胺/C13-14异链烷烃/月桂醇聚醚-7)等，本发明所用增稠剂为：聚丙烯酸酰胺类305(SEPPIGEL 305)、305增稠剂占本发明重量0.5-3.0％，进一步优化为0.6-1.5％，其它增稠剂还包括：硬脂酸、十六十八醇、硅酸铝镁、羟乙基纤维素、汉生胶等其中的一种或多种。
多元醇：多元醇可以包括甘油、1,3丁二醇、二丙二醇、本发明优选1,3丁二醇。1,3丁二醇在本发明化妆品中重量百分比为3％。
紫外线吸收剂：本发明化妆品当作为日霜使用可以包含一种以上防晒剂或UV紫外线吸收剂。所用防晒剂至少一种化合物其吸收波长在UVB区域(吸收波长为290-320纳米)，此外作为可选择的防晒剂还至少还包含一种吸收波长在UVA区域(吸收波长为320-400纳米)的化合物。因此，本发明所用紫外线吸收剂占本发明化妆品重量百分比约2-20％，进一步优化为10-15％，其中，丁基甲氧基二苯甲酰基甲烷占本发明化妆品重量0.5-2％，水杨酸乙基己酯占本发明化妆品重量3-5％，奥克立林占本发明化妆品重量6-8％。其余可以选择的紫外线吸收剂如：二苯甲酮2-10％、甲氧基肉桂酸乙基己酯2-10％、PAPA以及己酯1-8％、亚苄基樟脑磺酸1-6％、对氨基苯甲酸1-5％、乙基己基三嗪酮1-5％、苯基苯并咪唑磺酸及其钾、钠和三乙醇胺盐1-8％、二氧化钛1-25％、氧化锌1-25％等。
防腐剂：化妆品卫生规范中常规使用的防腐剂如，咪唑烷基脲，尼泊金类如羟苯甲酯和羟苯丙酯、苯氧乙醇、乙二胺四乙酸二钠盐(螯合剂)等，本发明优选适量的尼泊金类和苯氧乙醇，螯合剂为乙二胺四乙酸二钠盐。
实施例：实施例中Ⅰ、Ⅱ、Ⅲ、Ⅵ和Ⅶ为对比实施例(做实验对比使用)；此外，实施例Ⅳ、实施例Ⅴ、实施例Ⅷ、实施例Ⅸ，实施例Ⅹ为本发明实施例。
对比实施例：对比实施例Ⅰ为基础化妆品配方，除含有紫外线吸收剂和化妆品可接受的载体外，不含有任何其它抗氧化活性物质，四个对比实施例如：对比实施例Ⅱ、对比实施例Ⅲ、对比实施例Ⅵ和对比实施例Ⅶ，是在对比实施例Ⅰ的基础上增添了抗氧化物质如：维生素C磷酸酯镁、维生素E乙酸酯和阿魏酸等三种抗氧化成分。
实施例Ⅳ、Ⅴ、Ⅴ、Ⅷ、Ⅸ、Ⅹ。
本发明实施例共5个分别为，实施例Ⅳ、实施例Ⅴ、实施例Ⅷ、实施例Ⅸ、实施例Ⅹ。
本发明实施例是在对比实施例Ⅰ的基础上增加了姜黄素，含氟姜黄素A1，含氟姜黄素A2和含氟姜黄素A3等四种抗氧化成分。
功效评价
本发明一种含有抗氧剂的化妆品组合物测试本发明所含有的抗氧化剂与紫外线吸收剂的协同增效效果，本发明具有协同增效效果个抗氧化剂为姜黄素，含氟姜黄素A1、含氟姜黄素A2和含氟姜黄素A3的混合物，并与对比实施例中所使用的抗氧化剂如，维生素C磷酸酯镁，维生素E乙酸酯何阿魏酸的混合物进行对比；通过本发明实施例和对比实施例SPF值的对比进行判断前后两组抗氧化剂混合物与紫外线吸收剂的协同增效效果。
实施例Ⅰ-Ⅴ
Figure PCTCN2017100481-appb-000008
Figure PCTCN2017100481-appb-000009
其中：*四氢姜黄素，**1-(4-氟苯基)-3-(2-氟苯基)-丙烯酮，***1-(4-氟苯基)-3-(3-氟苯基)-丙烯酮，****1-(4-氟苯基)-3-(4-氟苯基)-丙烯酮。
实施例Ⅵ-Ⅹ
Figure PCTCN2017100481-appb-000010
Figure PCTCN2017100481-appb-000011
其中：*四氢姜黄素，**1-(4-氟苯基)-3-(2-氟苯基)-丙烯酮，***1-(4-氟苯基)-3-(3-氟苯基)-丙烯酮，****1-(4-氟苯基)-3-(4-氟苯基)-丙烯酮。
实施例Ⅰ-Ⅹ的SPF值测试结果
实施例 防晒指数SPF
Ⅰ对比 13
Ⅱ对比 13.5
Ⅲ对比 13.8
Ⅳ 15
Ⅴ 16
Ⅵ对比 13.8
Ⅶ对比 14
Ⅷ 16.3
Ⅸ 17
Ⅹ 17
SPF测试说明：实施例中Ⅰ、Ⅱ、Ⅲ、Ⅵ和Ⅶ为对比实施例(做实验对比使 用)其中实施例Ⅰ既不含有姜黄素和含氟姜黄素复合物也不含有常规的维生素C、维生素E和阿魏酸的复合物，测得的SPF值(人体法)为13.8；其它的四个实施例如，对比实施例Ⅱ、对比实施例Ⅲ、对比实施例Ⅵ和对比实施例Ⅶ均含有维生素C、维生素E和阿魏酸的复合物，但不含有本发明姜黄素和含氟姜黄素复合物，这四个对比实施例的SPF值分别为，对比实施例Ⅱ为13.5，对比实施例Ⅲ为13.8，对比实施例Ⅵ为13.8，对比实施例Ⅶ为14，)；此外，实施例Ⅳ、实施例Ⅴ、实施例Ⅷ、实施例Ⅸ和实施例Ⅹ为本发明实施例且均含有姜黄素和含氟姜黄素复合物，所测得的SPF值分别为，SPF15、SPF16、SPF16.3、SPF17、SPF17。
通过以上本发明实施例(实施例Ⅳ、实施例Ⅴ、实施例Ⅷ、实施例Ⅸ、实施例Ⅹ)与对比实施例的比较发现本发明实施例的防晒指数呈现梯度提升并且实施例Ⅸ的综合效果最好，5个对比实施例(Ⅰ、Ⅱ、Ⅲ、Ⅵ和Ⅶ)的防晒指数增长幅度不大。
结论：通过本发明Ⅰ-Ⅹ实施例的SPF测试数据看出，本发明含有姜黄素和含氟姜黄素的复合物化妆品与常规所使用的含有维生素E，维生素C和阿魏酸复合物的化妆品相比，本发明含有姜黄素和含氟姜黄素的复合物的化妆品防晒指数均高于含有常规使用的维生素E，维生素C和阿魏酸复合物化妆品的防晒指数。说明本发明中姜黄素和含氟姜黄素具有更加优异的抗氧化效果，并且与有机防晒剂一起使用具有协同增强化妆品(防晒乳)防晒指数的效果。
本发明的最佳实施例是实施例Ⅸ(一种含抗氧化剂的化妆品组合物)
组分 含量 重量％
丁基甲氧基二苯甲酰基甲烷 1.0
水杨酸乙基己酯 5.0
奥克立林 8.0
十六十八醇 1.0
聚甘油-3癸酸酯 1.0
鲸蜡硬脂醇聚醚-25 1.0
1,3-丁二醇 3.0
姜黄素* 0.4
含氟姜黄素A1** 0.25
含氟姜黄素A2*** 0.25
含氟姜黄素A3**** 0.25
增稠剂305 2.0
螯合剂、防腐剂、香精 适量
水 加至100％
*四氢姜黄素,**1-(4-氟苯基)-3-(2-氟苯基)-丙烯酮,***1-(4-氟苯基)-3-(3-氟苯基)-丙烯酮
****1-(4-氟苯基)-3-(4-氟苯基)-丙烯酮

Claims (4)

  1. 一种含有抗氧化剂的化妆品组合物，除化妆品可接受的载体：乳化剂、紫外线吸收剂、增稠剂、多元醇，适量的螯合剂、防腐剂、香精、以及去离子水外，还含有：
    A、占组合物重量0.05-0.6％的姜黄素；
    B、占组合物重量0.05-1.0％的姜黄素类似物，所述姜黄素类似物为含氟姜黄素。
  2. 根据权利要求1所述组合物，所述姜黄素为四氢姜黄素。
  3. 根据权利要求1所述组合物，所述含氟姜黄素为1-(4-氟苯基)-3-(2-氟苯基)-丙烯酮、1-(4-氟苯基)-3-(3-氟苯基)-丙烯酮、1-(4-氟苯基)-3-(4-氟苯基)-丙烯酮的混合物；且三种混合物重量比1-(4-氟苯基)-3-(2-氟苯基)-丙烯酮:1-(4-氟苯基)-3-(3-氟苯基)-丙烯酮:1-(4-氟苯基)-3-(4-氟苯基)-丙烯酮为1:1:1。
  4. 一种含有抗氧化剂的化妆品组合物，其组分及含量为：
    Figure PCTCN2017100481-appb-100001
    Figure PCTCN2017100481-appb-100002
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103622880A (zh) * 2013-12-20 2014-03-12 中南林业科技大学 山苍子油在防晒用品中的应用以及一种防晒组合物
CN104717969A (zh) * 2012-08-21 2015-06-17 北加州大学药学院 姜黄提取物的新型制剂和应用
CN105693492A (zh) * 2016-01-28 2016-06-22 聊城大学 一种单羰基姜黄素类似物及制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06128133A (ja) * 1992-10-20 1994-05-10 Kobe Steel Ltd 紫外線障害防御外用剤
US7597879B2 (en) * 2002-11-29 2009-10-06 Bioderm Research Sunscreen safety and efficacy enhancement
CN102772337B (zh) * 2012-08-17 2013-06-26 珀莱雅化妆品股份有限公司 一种复合美白脂质纳米粒乳液的制备方法
CN104721064A (zh) * 2013-12-23 2015-06-24 天津芸熙生物技术有限公司 一种美白皮肤的组合物及化妆品

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104717969A (zh) * 2012-08-21 2015-06-17 北加州大学药学院 姜黄提取物的新型制剂和应用
CN103622880A (zh) * 2013-12-20 2014-03-12 中南林业科技大学 山苍子油在防晒用品中的应用以及一种防晒组合物
CN105693492A (zh) * 2016-01-28 2016-06-22 聊城大学 一种单羰基姜黄素类似物及制备方法和用途

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DU, ZHIYUN ET AL.: "Curcumin's Bioactive and Application in Cosmetic", CHINA CLEANING INDUSTRY, 31 December 2005 (2005-12-31), pages 64 - 66 *
FAN, TAO ET AL.: "Synthesis of Curcumin-Cerium Coordination and Its Antioxidation Characteristics", APPLIED CHEMICAL INDUSTRY, vol. 40, no. 3, 31 March 2011 (2011-03-31), pages 392 - 394, XP055581677 *
LIAO, LI ET AL.: "Research Progress of Tetrahydrocurcumin", MODERNIZATION OF TRADITIONAL CHINESE MEDICINE AND MATERIA MEDICA-WORLD SCIENCE AND TECHNOLOGY, vol. 16, no. 12, 31 December 2014 (2014-12-31), pages 2708 - 2712 *
WEI, XINGCHUAN ET AL.: "Synthesis and Inhibitory Activity on Tyrosinase of Curcumin Fluoro-Analogues", GUANGZHOU CHEMICAL INDUSTRY, vol. 45, no. 8, 30 April 2017 (2017-04-30), pages 61 - 63 *

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