Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
  • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
  • A61M5/142—Pressure infusion, e.g. using pumps
  • A61M5/14212—Pumping with an aspiration and an expulsion action
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
  • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
  • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
  • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
  • A61M5/142—Pressure infusion, e.g. using pumps
  • A61M5/14212—Pumping with an aspiration and an expulsion action
  • A61M5/14216—Reciprocating piston type
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
  • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
  • A61M5/142—Pressure infusion, e.g. using pumps
  • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
  • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
  • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
  • A61M5/142—Pressure infusion, e.g. using pumps
  • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
  • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons flexible
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
  • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
  • A61M5/142—Pressure infusion, e.g. using pumps
  • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons
  • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons flexible
  • A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. by means of pistons flexible pressurised by contraction of elastic reservoirs
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/18—General characteristics of the apparatus with alarm
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/33—Controlling, regulating or measuring
  • A61M2205/3306—Optical measuring means
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/33—Controlling, regulating or measuring
  • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/33—Controlling, regulating or measuring
  • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
  • A61M2205/3386—Low level detectors
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
  • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
  • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
  • A61M2205/587—Lighting arrangements
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
  • A61M2205/702—General characteristics of the apparatus with testing or calibration facilities automatically during use
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/82—Internal energy supply devices
  • A61M2205/8206—Internal energy supply devices battery-operated

Definitions

• the present invention relates generally to a reservoir for delivering liquid.
• a specific embodiment of the invention relates to a flexible reservoir with a low volume sensor for delivering liquid medicinal products, such as insulin.
• An additional embodiment provides a method for operating a flexible reservoir with a low volume sensor including providing a warning that replacement of the flexible reservoir is needed.
• Diabetes is a group of diseases characterized by high levels of blood glucose resulting from the inability of diabetic patients to maintain proper levels of insulin production when required. Persons with diabetes will require some form of daily insulin therapy to maintain control of their glucose levels. Diabetes can be dangerous to the affected patient if it is not treated, and it can lead to serious health complications and premature death.
• the treatment options for diabetic patients include specialized diets, oral medications and/or insulin therapy.
• the main goal of diabetes treatment is to control the diabetic patient's blood glucose or sugar level.
• maintaining proper diabetes management may be complicated because it has to be balanced with the activities of the diabetic patient.
• syringes or insulin pens For the treatment of type 1 diabetes, there are two principal methods of daily insulin therapy.
• the first method diabetic patients use syringes or insulin pens to self- inject insulin when needed. This method requires a needle stick for each injection, and the diabetic patient may require three to four injections daily.
• the syringes and insulin pens that are used to inject insulin are relatively simple to use and cost effective.
• Another effective method for insulin therapy and managing diabetes is infusion therapy in which an insulin pump is used.
• the insulin pump can provide continuous infusion of insulin to a diabetic patient at varying rates in order to more closely match die functions and behavior of a properly operating pancreas of a non-diabetic person that produces the required insulin, and can help the diabetic patient maintain his/her blood glucose level within target ranges based on the diabetic patient's individual needs.
• a disposable component typically referred to as an infusion set, tubing set or pump set
• a patch pump is an integrated device that combines most or all of the fluidic components, including the fluid reservoir, pumping mechanism and a mechanism for automatically inserting the cannula, in a single housing which is adhesively attached to an infusion she on the patient's skin, and does not require the use of a separate infusion or tubing set.
• Some patch pumps may wirelessly communicate with a separate controller (as in one device sold by Insulet Corporation under the brand name OmniPod®), while others are completely self- contained. Such devices are replaced on a frequent basts, such as every three days, when the insulin reservoir is exhausted.
• a patch pump is designed to be a self-contained unit that is worn by the diabetic patient, it is preferable to be as small as possible so that it does not interfere with the activities of the user.
• its constituent parts should be reduced in size as much as possible.
• One such part is the reservoir for containing the insulin.
• a conventional rigid reservoir such as a syringe pump, controls the position of a plunger to dispense liquid.
• a major constraint of such a mechanism is the size of the system because it needs to accommodate both the length of the reservoir and the length of the plunger.
• a conventional rigid reservoir is difficult to deploy in a compact
• Low liquid level detection in the reservoir is important to ensure that the patch pump system functions correctly and/or to signal the need for replacement of the reservoir or patch pump.
• Various fill level detection systems have been proposed for various different applications. Currently, there are two principal methods for fill level detection. One provides electrical contacts points for metering doses. The other implements contactless fill level detection using capacitance measurement. [00010] There are many advantages of conventional fill level detection systems when the flow rate and fill level need to be constantly monitored and/or adjusted. Conventional fill level detection systems provide accurate fill level data constantly or at a plurality of time points. Such systems are well suited where constant monitoring and adjustment is necessary. When only a low volume warning is needed to signal the need for replacement of the reservoir, a system with fill level detection function is unnecessarily more costly and more complicated.
• An approach to reduce the overall size of a patch pump is to replace the syringe-type dosing mechanism by a downstream pump system drawing from a fluid reservoir.
• a miniaturized pump is arranged downstream of the fluid reservoir to produce a negative pressure gradient that conveys the fluid from the reservoir to its destination.
• the miniaturized pump can alternatively be arranged to produce a positive pressure gradient that conveys the fluid from another larger fluid source into the reservoir to fill the reservoir.
• a medical device for administering liquid drug therapy to a user with a low volume sensor
• said medical device comprising a flexible reservoir for containing a supply of a liquid drug, a rigid structure with a chamber and a side hole in fluid communication with the flexible reservoir, a plunger mounted inside the chamber and configured to seal one side of the chamber and a sensor for detecting low liquid volume in the flexible reservoir, wherein, when the inside end of the plunger passes the side hole, the sensor is activated to transmit a signal indicating low liquid volume in the flexible reservoir.
• a third aspect of the present invention provides a method for a method for detecting low liquid volume and notifying a user of time-to-empty in a system
• a pump mechanism a flexible reservoir for housing a supply of a liquid drug
• a rigid structure with a chamber and a side hole in fluid communication with the flexible reservoir
• a plunger mounted inside the chamber and configured to seal one side of the chamber
• a sensor for detecting low liquid volume in the flexible reservoir
• a control module in functional connection with the pump mechanism for controlling the operation of the pump mechanism, wherein when the inside end of the plunger passes the side hole, the sensor is activated to transmit a signal indicating low liquid volume in the flexible reservoir
• the method comprising the steps of providing the rigid structure with the chamber connected to the flexible reservoir, applying a negative pressure to end A of the rigid structure, removing fluid from the flexible reservoir, detecting moment that the plunger loses contact with the switch, calculating estimated time for empty based on current flow rate and volume of the chamber and the conduit, alerting the user that volume
• FIG. 1 is an illustration depicting a medical device in accordance with an embodiment of the present invention
• FIG.2 is an illustration of the empty condition of the medical device of FIG.
• FIG.3 is an illustration of the filled condition of the medical device of FIG.
• FIG.4 is a perspective view of a flexible reservoir implemented in a patch pump system
• FIG. 5 is a fluidic architecture and metering sub-system diagram of the patch pump system of Fig.4;
• FIG.6 is a flowchart illustrating a method for detecting low liquid volume and for notifying the user of estimated time-to-empty.
• an exemplary embodiments of the present invention includes a flexible reservoir 101 for housing a supply of a liquid drug, a rigid structure 120 with a chamber 102 and a side hole 104 in fluid communication with the flexible reservoir
• the term "flexible reservoir” includes reservoir structures that are both entirely flexible, such as collapsible fluid pouches or bladders, as well as reservoir structures that are only partially flexible by virtue of having both flexible and rigid wall portions.
• An exit/entrance 103 of the chamber 102 allows fluid in and out of the chamber 102.
• the plunger 105 is capable of moving in the axial direction of the chamber 102 from end A to end
• the plunger 105 is positioned in the chamber 102 such that it prevents liquid from leaking out of the chamber 102.
• a fluid source is connected to end A.
• the plunger 105 passes the side hole 104, fluid fills the chamber 102 and flows through the side hole 104 into the flexible reservoir 101 until the flexible reservoir 101 is filled.
• a sensor 106 is triggered to transmit a volume signal.
• medical device shown in FIG.l may be configured to be fully functional when the sensor 106 is an electrical switch. For instance, when the plunger 105 passes the side hole 104, an electrical signal is transmitted from the sensor 106 to indicate the volume information.
• the sensor 106 may also alternatively be implemented using an optical sensor. For instance, when the plunger 105 passes the side hole 104, an optical signal is transmitted from the sensor 106 to indicate the volume information.
• the sensor 106 may be implemented using a magnetic sensor.
• a pump or means can be arranged downstream of the flexible reservoir 101 and the chamber 102, to produce a negative pressure that conveys the fluid from the flexible reservoir 101 to its destination.
• similar means can be arranged to produce a positive pressure that conveys the fluid from another fluid source into the flexible reservoir 101 through the exit/entrance 103.
• the senor 106 is an electrical switch aligned with the end B of the chamber 102.
• the button or actuator 107 of the switch 106 is pointed toward the opening of the chamber 102.
• the plunger 105 moves from end A to end B and passes the side hole 104, the end of the plunger 105 touches the button 107 of the electrical switch and triggers the switch 106 to transmit a volume signal.
• additional supporting and housing structure may exist to support and house the above components.
• FIG.2 is an illustration of the low volume state of the present invention with a pump mechanism.
• the pump mechanism 110 is located downstream of the flexible reservoir 101.
• the initial position of the plunger 105 is in position B.
• the pump mechanism produces a negative pressure on the fluid inside the chamber 102 and the flexible reservoir 101. Fluid inside the flexible reservoir 101 flows through the side hole 104 into the chamber 102, and through the chamber exit/entrance 103 to conduit 111 to the pump mechanism 110.
• the negative pressure causes the flexible reservoir 101 to be emptied first
• continued negative pressure from the pump mechanism 110 causes the plunger 105 to move from position B toward position A, and the button 107 on the switch 106 is activated to transmit a low volume signal to a control module 109.
• Control module 109 men sends a low-volume warning signal to the user.
• FIG.3 is an illustration of the high volume state of the device of FIG.2.
• a fill syringe or other device is used to forcibly inject fluid through a valve or seal into the exit/entrance 103.
• the initial position of the plunger 105 is position A.
• the plunger 105 is pushed back by the positive pressure inside the chamber 102 produced by the filling device.
• the plunger 105 passes the side hole 104 in the chamber 102, fluid starts to flow into the flexible reservoir 101 through the side hole 104.
• the positive pressure increases and pushes the plunger 105 further back to position B to activate the button 107 on the switch 106 to transmit a high volume signal to the control module 109.
• the pump means 110 can be started to run at a pre-determined speed, the liquid in the flexible reservoir 101 will be pumped to the user and the flexible reservoir 101 will be emptied as illustrated in FIG.2, when the sensor 106 will be activated to transmit a low liquid volume signal.
• FIG. 4 is a perspective view of the flexible reservoir 101 implemented in a patch pump 1 A illustrated without a cover. Such arrangement may further reduce the external dimensions of the patch pump 1 A, with the flexible reservoir 101 filling voids within the patch pump 1 A.
• the patch pump 1A is illustrated with a cannula insertion device 7A that inserts the cannula into the surface of a user's skin.
• the patch pump 1A further comprises a power source 5A in the form of batteries; a metering sub-system 41 that monitors the volume of insulin and includes a low volume detecting means; control electronics 8A for controlling the components of the device; and a reservoir fill port 43 for receiving a fill syringe 45 to fill the reservoir 101.
• FIG.5 is a fluidic architecture and metering sub-system diagram of the patch pump 1 A of FIG. 4.
• the power storage sub-system for the patch pump 1A includes batteries 5A.
• the control electronics 8A of the patch pump 1A may include a microcontroller 81, sensing electronics 82, pump and valve controller 83, sensing electronics 85 and deployment electronics 87, that control the operation of the patch pump 1 A.
• the patch pump 1 A includes a fluidics sub-system that comprises the reservoir 101, a volume sensor 48 for the reservoir 101, and a reservoir fill port 43 for receiving a fill syringe 45 to fill the reservoir 4A.
• the fluidics sub-system may include a metering system comprising a pump and valve actuator 411 and an integrated pump and valve mechanism 413.
• the fluidics sub-system may further include an occlusion sensor 49, a deploy actuator or cannula insertion device 7, as well as a cannula 47 for insertion into an infusion site on the user's skin.
• the volume sensor is implemented with the sensor 106 of FIGs 1, 2 and 3.
• FIG. 6 is a flowchart illustrating the method for alerting the user of low liquid volume and for notifying the user of an estimated time-to-empty.
• step 602 when the flexible reservoir 101 is emptied by the application of a negative pressure to end A of the chamber 102, fluid flows out of the flexible reservoir 101 and through the chamber 102.
• step 603 this continues until all of the fluid is removed from the flexible reservoir 101.
• the negative pressure will build until it is sufficient to cause the plunger 105 to slide forward in the chamber 102.
• the back edge of the plunger 105 will lose contact with the button 107 of the switch, causing a low volume signal to be transmitted to the control module 109.
• step 604 the moment that the plunger 105 loses contact with the button 107 of the switch 106 is detected.
• the exact volume remaining in the system at this moment is known since it is equal to the volume of the conduit 111 and the portion of the chamber 102 not occupied by the plunger 105. Dividing this volume by the current flow rate of the liquid, which is known from the operating speed of the pump mechanism 110, yields the estimated amount of time left before the system becomes empty of fluid in step 605.
• step 606 the user of the system is alerted that the volume is low. If the flow rate is known, in step 607, the user can be notified of the approximate time that the system will run out of fluid.

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• Health & Medical Sciences (AREA)
• Vascular Medicine (AREA)
• Engineering & Computer Science (AREA)
• Anesthesiology (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Hematology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Dermatology (AREA)
• Infusion, Injection, And Reservoir Apparatuses (AREA)

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Citations (11)

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• 2017
  • 2017-08-31 US US15/692,887 patent/US10814062B2/en active Active
• 2018
  • 2018-08-29 EP EP18851105.9A patent/EP3675797B1/en active Active
  • 2018-08-29 CA CA3072497A patent/CA3072497A1/en active Pending
  • 2018-08-29 WO PCT/US2018/048537 patent/WO2019046421A1/en not_active Ceased
  • 2018-08-29 JP JP2020512484A patent/JP7385555B2/ja active Active
  • 2018-08-31 CN CN201821415681.8U patent/CN209137592U/zh not_active Withdrawn - After Issue
  • 2018-08-31 CN CN201811006576.3A patent/CN109420216B/zh active Active
• 2023
  • 2023-09-14 JP JP2023149270A patent/JP7667216B2/ja active Active

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