WO2019034113A1 - 预防和/或缓解痛经的大麻纤维及其在卫生用品中的应用 - Google Patents

预防和/或缓解痛经的大麻纤维及其在卫生用品中的应用 Download PDF

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Publication number
WO2019034113A1
WO2019034113A1 PCT/CN2018/100840 CN2018100840W WO2019034113A1 WO 2019034113 A1 WO2019034113 A1 WO 2019034113A1 CN 2018100840 W CN2018100840 W CN 2018100840W WO 2019034113 A1 WO2019034113 A1 WO 2019034113A1
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Prior art keywords
hemp fiber
hemp
fiber
dtex
preventing
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PCT/CN2018/100840
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English (en)
French (fr)
Inventor
张可
谭昕
常坦然
连萌
金倩
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汉义生物科技（北京）有限公司
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Publication of WO2019034113A1 publication Critical patent/WO2019034113A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/45—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the shape
    • A61F13/47—Sanitary towels, incontinence pads or napkins
    • A61F13/472—Sanitary towels, incontinence pads or napkins specially adapted for female use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine

Definitions

  • the present invention relates to a material, and more particularly to a material for preventing and/or alleviating dysmenorrhea in a woman.
  • Cannabis genus is an annual herb, the scientific name cannabis Salival, commonly known as hemp, cold hemp, line hemp, flower hemp, etc., the variety of cannabis is about 150, mainly distributed in Asia, Europe, China is the Asian cannabis production center, cultivation area And production ranks first in the world, producing all over the country.
  • Hemp fiber has good moisture absorption and air permeability, sound absorbing and absorbing function, antistatic, anti-ultraviolet radiation and excellent properties such as heat resistance, light fastness, corrosion resistance, mildewproof and antibacterial. Hemp fibers can be either single-spun or blended with other fibers depending on the blend ratio.
  • hemp fiber The molecular structure of hemp fiber is stable, the orientation of the molecular arrangement is good, the electrostatic generating ability is extremely low, and the hygroscopicity is good, which provides a reliable guarantee for low static electricity and can avoid static electricity accumulation.
  • Hemp fiber also has a high void ratio, which has good sound absorption and gas permeability, and has good heat resistance.
  • Hemp fiber contains lignin and hemicellulose, and has a special surface structure and irregular cross section. Therefore, hemp fiber has excellent dissipating effect on sound waves and light waves, and has excellent protection effect against ultraviolet radiation.
  • hemp fiber products have high tensile strength, good shape retention, good hygroscopicity, strong antibacterial and antistatic ability, good adsorption performance for dyes, strong UV radiation resistance, and strong hemp fiber.
  • hemp fiber also contains active ingredients such as cannabinoids, flavonoids and alkaloids, and has certain anti-fungal and antibacterial functions. Hemp fibers have obvious effects on Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. Killing effect; high-frequency plasma emission spectrometer analysis, hemp fiber contains a variety of trace elements beneficial to human health, and hollow hemp fiber, usually rich in oxygen, also makes anaerobic bacteria difficult to survive. In addition, hemp fiber has the advantages of softness, hygiene and the like. The hemp fiber has an obtuse angle at both ends, so the hemp fabric is soft and has no prickle.
  • active ingredients such as cannabinoids, flavonoids and alkaloids
  • Dysmenorrhea is a common and frequently-occurring disease in gynecology. It has many causes, complicated pathogenesis, large repeatability, and difficult treatment. Especially unmarried women and girls in early menstruation are more common. It is characterized by periodic abdominal pain before and after menstruation or menstruation. Cold pain, burning pain, tingling, dull pain, falling pain, colic, sputum pain, tearing pain, pain extending to the back of the back, even involving the thighs and feet, and even with systemic symptoms, seriously affecting women Work and study reduce the quality of life.
  • Patent CN1658840A discloses a film-form mucoadhesive administration form for administering a cannabis preparation, wherein the preparation is capable of treating and improving dysmenorrhea, and the preparation comprises at least one selected from the group consisting of tetrahydrocannabinol, cannabidiol, and marijuana. Group of phenol and cannabis pigments.
  • Patent CN103806153A discloses a multi-component blended antibacterial and deodorant health-care yarn for hemp fiber, which comprises 15-30% of hemp fiber, 20-40% of aloe viscose fiber, 30-50% of wool fiber, and 10-35% of cashmere fiber.
  • the single yarn has a breaking strength of 11.9 to 19.8 cN/tex and has health functions such as antibacterial, antibacterial, antibacterial and anti-inflammatory.
  • Patent CN206324233U discloses a panty for women.
  • the panty body is composed of a front piece and a back piece, and the front piece and the back piece are both a first hemp fiber layer, a second hemp fiber layer, a filter layer and
  • the water absorbing layer is composed of the first hemp fiber layer and the second hemp fiber layer, which are made of hemp fiber, can inhibit bacterial growth, eliminate inflammation, and naturally eliminate odor.
  • Patent CN102920551A discloses a hemp antibacterial sanitary napkin which is prepared by mixing hemp fibers in hemp rods and mixing hemp fibers with ES fibers in a mass ratio of 20% to 0%:80% to 60%. Antibacterial surface material for towels.
  • Patent CN101831715B discloses a hemp fiber with high fineness and strength.
  • the hemp fiber has a fineness of 1500-4000 gongs and a strength of 4-10 cN/dtex. It can be prepared by dry spinning and other fiber blending. Grade textile products.
  • Patent CN106567138A discloses a method for refining hemp fibers, comprising a cooking and removing step of hemp bast, a steam flash explosion activation treatment step, a cake filling step, a directed catalytic oxidation step, a chemical degumming step and a post-processing step;
  • the obtained hemp fiber finished product has a fineness of 2.2 to 3.5 dtex, a residual rubber ratio of 2.44 to 3.82%, a fiber strength of 2.7 to 3.3 cN/dtex, and an average fiber length of more than 30 mm.
  • Patents CN101273938A, CN102090950A, CN103751471A, CN105457079A, and CN102038975A, etc. disclose sanitary napkins made of non-woven fabric for relieving and treating dysmenorrhea.
  • the present invention provides a hemp fiber and a product thereof which have good relief and treatment effects on female dysmenorrhea by controlling cannabis fiber and cannabinoid compound in fiber.
  • a first aspect of the present invention provides a hemp fiber which can prevent and/or alleviate dysmenorrhea in a woman, wherein the hemp fiber has a fineness of 0.2 to 2 dtex, a strength of 1.5 to 8 cN/dtex, and a length of 10 to 50 mm.
  • the hemp fiber of the present invention has a fineness of 0.5 to 1.5 dtex, and more preferably, the hemp fiber has a fineness of 1 to 1.5 dtex.
  • the hemp fiber of the present invention has a strength of 2 to 6 cN/dtex, and more preferably, the hemp fiber of the present invention has a strength of 3 to 4.5 cN/dtex.
  • the length of the hemp fiber of the present invention is 10 to 50 mm, and more preferably, the length of the hemp fiber of the present invention is 10 to 40 mm, and particularly preferably, the length of the hemp fiber of the present invention is 10 -20mm.
  • hemp fibers due to the presence of cannabinoids in cannabis plants, some cannabinoids remain in the preparation process of hemp fibers, especially the surface of hemp fibers and internal voids become the site of distribution of cannabinoids, while hemp fibers
  • the fineness and length determine the specific surface area of the hemp fiber and the spatial size of the internal voids. Therefore, the present invention found that the specific fineness and strength of the hemp fiber have a significant difference in the degree of relief of dysmenorrhea.
  • the hemp fibers of different fineness, strength and length are woven into sanitary materials, the degree of contact between the finished product and the human tissue changes due to the different degrees of slack after molding, and the final effect is also affected.
  • the content of the cannabinoid compound in the hemp fiber is not less than 0.01% by mass, and more preferably, the content of the cannabinoid compound in the hemp fiber is percentage by mass. Not less than 0.05%, particularly preferably, the content of the cannabinoid compound in the hemp fiber is not less than 0.08% by mass. It will be understood by those skilled in the art that the cannabinoid compound in the hemp fiber may be residual in the hemp fiber, or the cannabinoid compound may be added in the preparation process to achieve the cannabinoid compound in the hemp fiber. The content.
  • the content of the cannabidiol in the hemp fiber is not less than 0.002% by mass.
  • the content of the cannabidiol in the hemp fiber is not less than 0.004% by mass, more preferably, The content of cannabidiol in the hemp fiber is not less than 0.007% by mass.
  • the cannabidiol in the hemp fiber may be residual in the hemp fiber or may be added by the preparation process to achieve the content of the cannabidiol in the hemp fiber.
  • a second aspect of the present invention provides a feminine hygiene product for preventing and/or relieving dysmenorrhea, wherein the feminine hygiene product comprises hemp fiber, the hemp fiber having a fineness of 0.2 to 2 dtex and a strength of 1.5 to 8 cN/dtex.
  • the length is 10 to 50 mm.
  • the feminine hygiene product of the present invention is a sanitary napkin, a sanitary pad, a tampon.
  • the feminine hygiene product is a sanitary napkin.
  • the hemp fiber described in the feminine hygiene product of the present invention may be prepared by separate weaving, or may be prepared by mixing with other fibers.
  • the other fibers are selected from natural fibers or synthetic fibers, and the natural fibers are selected from the group consisting of viscose fibers, cotton fibers, wool fibers, and cashmere fibers, and the synthetic fibers are selected from the group consisting of polyamide fibers and polyester fibers. , meta-aramid fiber, modacrylic fiber, polyoxadiazole fiber, polyacrylonitrile fiber, polyvinyl alcohol fiber.
  • the feminine hygiene product of the present invention is prepared by mixing hemp fibers with other fibers, the ratio of the hemp fibers to the other fibers may be 1:99-99:1, preferably: 30:70-70: 30, particularly preferably 60:40-80:20.
  • the feminine hygiene product is a sanitary napkin, the sanitary napkin comprising a top layer, an absorbent inner layer and an outer layer, the top layer being made of the hemp fiber. Fabric.
  • the absorbent inner layer is one or more selected from the group consisting of hemp fiber, cotton, non-woven fabric, pulp, or a polymer formed of a composite of hemp fiber, cotton, non-woven fabric, and pulp. Made of, preferably hemp fiber.
  • the outer layer is made of a fabric, a nonwoven fabric or a film material selected from the group consisting of hemp fibers.
  • a third aspect of the present invention provides a use of hemp fiber for preparing a product for preventing and/or alleviating dysmenorrhea in a woman, wherein the hemp fiber has a fineness of 0.2 to 2 dtex, a strength of 1.5 to 8 cN/dtex, and a length of 10 to 50 mm.
  • the hemp fiber according to the present invention can adopt any existing preparation method, as long as the hemp fiber prepared by the method has a fineness of 0.2 to 2 dtex and a strength of 1.5 to 8 cN/dtex.
  • the length is 10 to 50 mm.
  • the preparation method of the hemp fiber includes degumming, water washing, oil feeding, dehydration, and drying.
  • the degumming step comprises a chemical degumming method, a biological enzyme degumming method, a physical degumming method
  • the hemp fiber may be combined by a chemical degumming method and a biological enzyme degumming method, or a combination of a chemical degumming method and a physical degumming method.
  • it is prepared by combining biological enzymatic degumming method with physical degumming method, or by combining chemical degumming method, biological enzymatic degumming method and physical degumming method.
  • the preparation method of the hemp fiber comprises degumming, water washing, oiling, dehydrating and drying, and the preparation method further comprises the step of adding a cannabinoid compound to the hemp fiber.
  • the step of adding the cannabinoid compound to the hemp fiber is to add a cannabinoid compound before oiling, or to add a cannabinoid compound after oiling. More preferably, the manner of addition is selected from the group consisting of injection, spray addition, solution mixing and the like.
  • the addition time and the manner of addition of the cannabinoid compound can be arbitrarily selected as long as the content of the cannabinoid compound in the hemp fiber is not less than 0.01% by mass, preferably, The content of the cannabinoid compound in the hemp fiber is not less than 0.05% by mass. Particularly preferably, the content of the cannabinoid compound in the hemp fiber is not less than 0.08% by mass.
  • the cannabinoid compound of the present invention is selected from one or more selected from the group consisting of cannabinol, cannabidiol, tetrahydrocannabinol, cannabinol, tetrahydrocannabinol, cannabinoid acid, and cannabinol.
  • the combination Preferably, the cannabinoid compound is cannabidiol.
  • the content of cannabidiol in the hemp fiber is not less than 0.002% by mass.
  • the content of cannabidiol in the hemp fiber is not less than 0.004% by mass, more preferably The content of cannabidiol in the hemp fiber is not less than 0.007% by mass.
  • the cannabidiol in the hemp fiber may be residual in the hemp fiber or may be added by the preparation process to achieve the content of the cannabidiol in the hemp fiber.
  • the cannabinoid compound added to the hemp fiber of the present invention is extracted from a cannabis plant, and the extracting site of the cannabis plant is preferably one of hemp seed, hemp leaf, cannabis flower, hemp stalk core, and hemp root. Or any combination of two or more in any ratio.
  • the cannabinoid compound may be obtained by separately extracting different plant parts of the cannabis plant, such as a cannabinoid compound obtained by extracting cannabis flowers and a cannabinoid compound obtained by extracting the cannabis leaf; A combination of a cannabinoid compound, a cannabinoid compound obtained by extracting cannabis, and a cannabinoid compound obtained by extracting a cannabis leaf.
  • the cannabinoid compound may also be a combination of different plant parts of the cannabis plant, such as cannabis resin obtained from cannabis flower and leaf extraction; cannabinoids obtained from cannabis stalk core and flower and leaf extract; cannabis Cannabinoids obtained from stalk core and flower extraction; cannabinoids obtained from cannabis stalk core and leaf extraction; cannabinoids obtained from cannabis flower and leaf extraction, and cannabinoids extracted from cannabis leaf and stalk core Combination and other forms.
  • cannabis resin obtained from cannabis flower and leaf extraction cannabinoids obtained from cannabis stalk core and flower and leaf extract
  • cannabis Cannabinoids obtained from stalk core and flower extraction cannabinoids obtained from cannabis stalk core and leaf extraction
  • cannabinoids obtained from cannabis flower and leaf extraction cannabinoids extracted from cannabis leaf and stalk core Combination and other forms.
  • the cannabinoid compound of the present invention can be prepared by a conventional plant extraction method in the prior art, such as solvent extraction, steam distillation, sublimation, supercritical fluid extraction, membrane extraction separation, etc.;
  • the solvent extraction method may be employed, and the extraction solvent may be: a low molecular alcohol (such as methanol, ethanol, butanol or propanol), an acetate (such as methyl acetate or ethyl acetate), a ketone (such as acetone), an ether ( Such as methyl ether or ether), low-boiling aliphatic hydrocarbons or aromatic hydrocarbons or chlorinated hydrocarbons;
  • the extraction process can be heated reflux, and can also be combined with other extraction and separation methods such as extraction, distillation, crystallization, chromatographic separation, etc.
  • the extract may be further purified and separated by a combination of multiples.
  • a fourth aspect of the invention relates to a method for preventing and/or relieving dysmenorrhea, which comprises applying a feminine hygiene product containing hemp fiber, the hemp fiber having a fineness of 0.2 to 2 dtex and a strength of 1.5 to ⁇ 8cN/dtex, length 10 ⁇ 50mm.
  • the content of the cannabinoid compound in the hemp fiber is not less than 0.01% by mass.
  • the hemp fiber and the feminine hygiene product provided by the invention can effectively prevent and alleviate female dysmenorrhea, and provide a new idea for relieving and treating female dysmenorrhea.
  • treating includes inhibiting, delaying, alleviating, attenuating, limiting, alleviating or ameliorating a disease, disorder, condition or condition, its occurrence and/or progression, and/or its symptoms.
  • prevention includes reducing the risk of having, infecting or experiencing a disease, disorder, condition or condition, its occurrence and/or progression, and/or its symptoms.
  • the term "about” as used in the present invention generally means +/- 5% of said value, more generally +/- 4% of said value, more generally +/- 3% of said value, more usually Refers to +/- 2% of the stated value, more generally +/- 1% of the stated value, more generally +/- 0.5% of the stated value.
  • the raw material cannabis peel that has been processed in the preparation process and placed in the oxidizing solution is 1 kg of hemp skin with 10 kg of water (ie, a bath ratio of 1:10), and the oxidizing solution contains hydrogen peroxide (amount of pure H 2 O 2 ). 10g / L, sodium tripolyphosphate 3g / L, urea 2g / L.
  • the temperature of the oxidizing solution was raised to 90 ° C at a constant rate for 30 min, and the temperature was maintained for 1 h; the oxidized hemp skin was rinsed with tap water and placed in an alkali cooking solution containing sodium hydroxide 7 g/L and sodium tripolyphosphate 1.5.
  • urea 2g/L, bath ratio is 1:10 (10 kg per kg of hemp skin water), warmed to 80 ° C in 35 min, kept at constant temperature for 4 h; the hemp fiber after alkali boiling was placed in the post-treatment liquid,
  • the content of the fiber leavening agent (mixing agent of BK-100 and urea 2:1) in the post-treatment liquid is 4 g/L
  • the bath ratio of the post-treatment liquid to the hemp fiber is 1:10
  • the post-treatment temperature is 60 ° C. Reaction for 60 min.
  • hemp fiber was washed with tap water to remove the residual medicine and impurities on the fiber surface.
  • the hemp fiber is dehydrated and immersed in an emulsified oil.
  • the emulsified oil used for 1 kg of hemp fiber contains 30 g of mechanical oil, 5 g of NaOH, 10 g of detergent, and 10 kg of water, and is kept at 90 ° C for 1 h. Remove the hemp fiber from the emulsified oil, dehydrate, dry, soft hemp, spray the emulsion.
  • the emulsion used in 1 kg of hemp fiber contains: oil 15g, NaOH 6g, detergent 7.5g, water 100g, after spraying the emulsion In a constant temperature chamber of 35 °C, it is allowed to stand for 37 hours; after the initial opening of the hemp fiber, it is fed into the carding machine, the carding machine raises the cotton board by 3 cm, and the spacing between the licker and the feeding board is 3.0 mm.
  • Table 1 The obtained hemp fiber performance indicators are shown in Table 1.
  • the raw material cannabis peel that has been processed in the preparation process and placed in the oxidizing solution is 1 kg of hemp skin with 10 kg of water (ie, a bath ratio of 1:10), and the oxidizing solution contains hydrogen peroxide (amount of pure H 2 O 2 ). 8g / L, sodium tripolyphosphate 2g / L, urea 2g / L.
  • the temperature of the oxidizing solution was raised to 90 ° C at a constant rate for 30 min, and the temperature was maintained for 1 h; the oxidized hemp skin was rinsed with tap water and placed in an alkali cooking solution containing sodium hydroxide 6 g/L and sodium tripolyphosphate 1.5.
  • urea 2g/L, bath ratio is 1:10 (10 kg per kg of hemp skin water), warmed to 80 ° C in 35 min, kept at constant temperature for 4 h; the hemp fiber after alkali boiling was placed in the post-treatment liquid,
  • the content of the fiber leavening agent (mixing agent of BK-100 and urea 2:1) in the post-treatment liquid is 4 g/L
  • the bath ratio of the post-treatment liquid to the hemp fiber is 1:10
  • the post-treatment temperature is 55 ° C. Reaction for 60 min.
  • hemp fiber was washed with tap water to remove the residual chemicals and impurities on the fiber surface.
  • the hemp fiber is dehydrated and immersed in an emulsified oil.
  • the emulsified oil used for 1 kg of hemp fiber contains 10 g of mechanical oil, 5 g of NaOH, 10 g of detergent, and 10 kg of water, and is kept at 90 ° C for 1 h. Remove the hemp fiber from the emulsified oil, dehydrate, dry, soft hemp, spray the emulsion.
  • the emulsion used in 1 kg of hemp fiber contains: oil 15g, NaOH 6g, detergent 7.5g, water 100g, after spraying the emulsion In the 35 °C constant temperature chamber, it is allowed to stand for 37 hours; after the hemp fiber is initially opened, it is fed into the carding machine, the carding machine raises the cotton board by 2 cm, and the spacing between the licker roller and the feeding board is 2.0 mm.
  • the obtained hemp fiber performance indicators are shown in Table 2.
  • the raw material cannabis peel that has been processed in the preparation process and placed in the oxidizing solution is 1 kg of hemp skin with 10 kg of water (ie, a bath ratio of 1:10), and the oxidizing solution contains hydrogen peroxide (amount of pure H 2 O 2 ). 12 g / L, sodium tripolyphosphate 3 g / L.
  • the temperature of the oxidizing solution was raised to 90 ° C at a constant rate for 30 min, and the temperature was maintained for 1 h.
  • the oxidized cannabis skin was rinsed with tap water and then placed in an alkali cooking solution containing sodium hydroxide 8 g/L and sodium tripolyphosphate 1.5.
  • urea 2g/L, bath ratio is 1:10 (10 kg per kg of hemp skin water), warmed to 80 ° C in 35 min, kept at constant temperature for 4 h; the hemp fiber after alkali boiling was placed in the post-treatment liquid,
  • the content of the fiber leavening agent (mixing agent of BK-100 and urea 2:1) in the post-treatment liquid is 4 g/L
  • the bath ratio of the post-treatment liquid to the hemp fiber is 1:10
  • the post-treatment temperature is 60 ° C. Reaction for 60 min.
  • hemp fiber was washed with tap water to remove the residual chemicals and impurities on the fiber surface.
  • the hemp fiber is dehydrated and immersed in an emulsified oil.
  • the emulsified oil used for 1 kg of hemp fiber contains 15 g of mechanical oil, 2 g of NaOH, 10 g of detergent, and 10 kg of water, and is kept at 90 ° C for 1 h. Remove the hemp fiber from the emulsified oil, dehydrate, dry, soft hemp, spray the emulsion.
  • the emulsion used in 1 kg of hemp fiber contains: oil 18g, NaOH 4g, detergent 7.5g, water 100g, after spraying the emulsion In the 35 °C constant temperature chamber, it is allowed to stand for 37 hours; after the hemp fiber is initially opened, it is fed into the carding machine, the carding machine raises the cotton board by 4 cm, and the spacing between the licker roller and the feeding board is 4.0 mm.
  • Table 3 The obtained hemp fiber performance indicators are shown in Table 3.
  • the raw material cannabis peel that has been processed in the preparation process and placed in the oxidizing solution is 1 kg of hemp skin with 10 kg of water (ie, a bath ratio of 1:10), and the oxidizing solution contains hydrogen peroxide (amount of pure H 2 O 2 ). 10g / L, sodium tripolyphosphate 3g / L, urea 2g / L.
  • the temperature of the oxidizing solution was raised to 100 ° C at a constant rate for 30 min, and the temperature was maintained for 2 h.
  • the oxidized hemp skin was rinsed with tap water and placed in an alkali cooking solution containing sodium hydroxide 6 g/L and sodium tripolyphosphate 2 g.
  • hemp fiber was washed with tap water to remove the residual chemicals and impurities on the fiber surface.
  • the hemp fiber is dehydrated and immersed in an emulsified oil.
  • the emulsified oil used in 1 kg of hemp fiber contains 20 g of mechanical oil, 5 g of NaOH, 10 g of detergent, and 10 kg of water, and is kept at 90 ° C for 1 h. Remove the hemp fiber from the emulsified oil, dehydrate, dry, soft hemp, spray the emulsion.
  • the emulsion used in 1 kg of hemp fiber contains: oil 20g, NaOH 2g, detergent 7.5g, water 100g, after spraying the emulsion In a constant temperature chamber of 35 °C, it is allowed to stand for 37 hours; after the initial opening of the hemp fiber, it is fed into the carding machine, the carding machine raises the cotton board by 5 cm, and the spacing between the licker roller and the feeding board is 2.0 mm.
  • the obtained hemp fiber performance indicators are shown in Table 4.
  • the raw material hemp skin processed in accordance with the production process is placed in a sulfuric acid solution having a concentration of 2 g/l, and 1 kg of hemp skin is treated with a 2 g/l sulfuric acid solution of 10 kg (i.e., a bath ratio of 1:10).
  • the hemp skin is washed with water and then placed in the alkali cooking liquid, the alkali cooking liquid contains sodium hydroxide 7g / L, sodium sulfite 3% , 5% trisodium phosphate, bath ratio of 1:10 (10 kg per kg of hemp fiber), warmed to 80 ° C for 35 min, kept at constant temperature for 3 h; then rinse the hemp fiber with tap water for 5 min, then put the hemp fiber washed with tap water
  • the acid solution contains 1 g/l of sulfuric acid, and after standing for 2 min, the hemp fiber is washed with tap water for 5 min, and the hemp fiber is placed in an 8% owf pectinase solution at pH 3.5, and the bath ratio is 1:10 ( 10 kg of water per kg of cannabis, maintain a constant temperature of 50 ° C, reaction for 8 h, remove the hemp fiber in 85 ° C hot
  • the raw material hemp skin processed in accordance with the production process is placed in a sulfuric acid solution having a concentration of 2 g/l, and 1 kg of hemp skin is treated with a 2 g/l sulfuric acid solution of 10 kg (i.e., a bath ratio of 1:10).
  • the hemp skin is washed with water and then placed in the alkali cooking liquid, the alkali cooking liquid contains sodium hydroxide 10g / L, sodium sulfite 2% 3% trisodium phosphate, the bath ratio is 1:10 (10 kg per kg of hemp fiber), the temperature is raised to 80 ° C for 35 min, and kept at a constant temperature for 3 h; then the hemp fiber is washed with tap water for 5 min, and the hemp fiber washed with tap water is placed.
  • the acid solution contains 1 g/l of sulfuric acid, and after standing for 2 min, the hemp fiber is washed with tap water for 5 min, and the hemp fiber is placed in a 10% owf pectinase solution at pH 3.5, and the bath ratio is 1:10 ( 10 kg of water per kg of cannabis, maintain a constant temperature of 50 ° C, reaction for 8 h, remove the hemp fiber in 85 ° C hot water, let stand for 30 min, remove the hemp fiber, rinse with tap water for 5 min, dehydrate the hemp fiber, dry, soft Hemp, spray emulsion, 1 kg of marijuana
  • the emulsion used in the dimension contains: 15g of oil, 8g of NaOH, 7.5g of detergent, 100g of water.
  • hemp fiber performance indexes are shown in Table 6.
  • the raw material hemp skin processed in accordance with the production process is placed in a sulfuric acid solution having a concentration of 2 g/l, and 1 kg of hemp skin is treated with a 3 g/l sulfuric acid solution of 10 kg (i.e., a bath ratio of 1:10).
  • the hemp skin is washed with water and then placed in the alkali cooking liquid, the alkali cooking liquid contains sodium hydroxide 10g / L, sodium sulfite 2% , 5% trisodium phosphate, bath ratio of 1:10 (10 kg per kg of hemp fiber), warmed to 80 ° C for 35 min, kept at constant temperature for 3 h; then rinse the hemp fiber with tap water for 5 min, then put the hemp fiber washed with tap water
  • the acid solution contains 1 g/l of sulfuric acid, and after standing for 2 min, the hemp fiber is washed with tap water for 5 min, and the hemp fiber is placed in a 8% owf pectinase solution at pH 4, and the bath ratio is 1:10 (per kg Cannabis water 10 kg), maintain a constant temperature of 50 ° C, reaction for 8 h, remove the hemp fiber in 85 ° C hot water,
  • hemp fiber performance indicators are shown in Table 7.
  • the raw material hemp skin processed in accordance with the production process is placed in a sulfuric acid solution having a concentration of 2 g/l, and 1 kg of hemp skin is treated with a 2 g/l sulfuric acid solution of 10 kg (i.e., a bath ratio of 1:10).
  • a sulfuric acid solution having a concentration of 2 g/l
  • 1 kg of hemp skin is treated with a 2 g/l sulfuric acid solution of 10 kg (i.e., a bath ratio of 1:10).
  • the reaction was carried out for 1 h.
  • the hemp skin was taken out from the sulfuric acid solution, and then the hemp skin was washed with tap water for 5 min.
  • the hemp skin was washed with water and then placed in an alkali cooking solution containing 7 g/L of sodium hydroxide and 6% of sodium sulfite.
  • the bath ratio is 1:10 (10 kg per kg of hemp fiber), the temperature is raised to 80 ° C in 35 min, and the temperature is kept constant for 3 h; then the hemp fiber is washed with tap water for 5 min, and the hemp fiber washed with tap water is placed in the acid solution, acid The solution contains 1 g/l of sulfuric acid. After standing for 2 min, the hemp fiber is washed with tap water for 5 min, and the hemp fiber is placed in an 8% owf pectinase solution at pH 3.5.
  • the bath ratio is 1:10 (10 kg per kg of cannabis water) ), maintain a constant temperature of 50 ° C, reaction for 8 h, remove the hemp fiber in 85 ° C hot water, let stand for 30 min, remove the hemp fiber, rinse with tap water for 5 min, dehydrate the hemp fiber, dry, soft hemp, spray cannabinol Compound suspension, followed by spraying milk Chemical solution, 1 kg of hemp fiber used in the emulsion contains: oil 30g, NaOH 7g, detergent 9g, 100g of water, spray emulsion after placing in a 35 ° C constant temperature chamber, standing for 37h; after the initial opening of hemp fiber Feeding into the carding machine, the carding machine raises the cotton board by 3cm, and the spacing between the licker and the feeding board is 3.0mm.
  • the preparation method of the cannabinoid compound suspension is as follows: the cannabis leaf is dried, pulverized and sieved; the obtained powder is extracted twice with an 8-fold amount and 50% ethanol for 1.5 hours; the extract is combined, Decolorization by activated carbon adsorption; concentrated under reduced pressure to a relative density of 1.02 at 70 ° C, to obtain extract extract, wherein the content of cannabinoids in the extract extract is 45%, and the cannabinoids in cannabinoids The content is 92%, and a suitable suspension is added to prepare a suspension for use.
  • the method for determining the content of cannabinoids is to react specifically with phenol and FoLin-CiocaLteu reagent, and the reaction product has maximum absorption at a specific wavelength, and the absorbance value is linear with the amount of phenol in a certain concentration range.
  • a standard curve is established by using standard phenolic substances, and then the absorbance of the sample to be tested is measured, and the content of polyphenols in the sample to be tested can be obtained.
  • the content of CBD was determined by high performance liquid chromatography, and the internal standard solution was prepared with CBD reference material for making a standard curve.
  • the column used for the determination of CBD content was C 18 column (3.9 mm ⁇ 300 mm, 10 um), the mobile phase had methanol and water of 80:20, the detection wavelength was 210 nm, the flow rate was 1 ml/min, and the injection volume was 20 ul.
  • the obtained hemp fiber performance indicators are shown in Table 8.
  • the raw material hemp skin processed in accordance with the production process is placed in a sulfuric acid solution having a concentration of 2 g/l, and 1 kg of hemp skin is treated with a 2 g/l sulfuric acid solution of 10 kg (i.e., a bath ratio of 1:10).
  • a sulfuric acid solution having a concentration of 2 g/l
  • 1 kg of hemp skin is treated with a 2 g/l sulfuric acid solution of 10 kg (i.e., a bath ratio of 1:10).
  • the reaction was carried out for 1 h.
  • the hemp skin was taken out from the sulfuric acid solution, and then the hemp skin was washed with tap water for 5 min.
  • the hemp skin was washed with water and then placed in an alkali cooking solution containing 7 g/L of sodium hydroxide and 6% of sodium sulfite.
  • the bath ratio is 1:10 (10 kg per kg of hemp fiber), the temperature is raised to 80 ° C in 35 min, and the temperature is kept constant for 3 h; then the hemp fiber is washed with tap water for 5 min, and the hemp fiber washed with tap water is placed in the acid solution, acid The solution contains 1 g/l of sulfuric acid. After standing for 2 min, the hemp fiber is washed with tap water for 5 min, and the hemp fiber is placed in an 8% owf pectinase solution at pH 3.5.
  • the bath ratio is 1:10 (10 kg per kg of cannabis water) ), maintain a constant temperature of 50 ° C, reaction for 8 h, remove the hemp fiber in 85 ° C hot water, let stand for 30 min, remove the hemp fiber, rinse with tap water for 5 min, dehydrate the hemp fiber, dry, soft hemp, spray cannabinol Compound suspension (same as in Example 8 Preparation method), after spraying the emulsion, the emulsion used in 1 kg of hemp fiber contains: oil 255g, NaOH 6.5g, detergent 8.5g, 100g of water, sprayed the emulsion and placed in a 35 ° C constant temperature chamber, allowed to stand 37h; After the initial opening of the hemp fiber, it is fed into the carding machine, the carding machine raises the cotton board by 3cm, and the spacing between the licker and the feeding board is 3.0mm.
  • the method for determining the content of cannabinoids is to react specifically with phenol and FoLin-CiocaLteu reagent, and the reaction product has maximum absorption at a specific wavelength, and the absorbance value is linear with the amount of phenol in a certain concentration range.
  • a standard curve is established by using standard phenolic substances, and then the absorbance of the sample to be tested is measured, and the content of polyphenols in the sample to be tested can be obtained.
  • the content of CBD was determined by high performance liquid chromatography, and the internal standard solution was prepared with CBD reference material for making a standard curve.
  • the column used for the determination of CBD content was C 18 column (3.9 mm ⁇ 300 mm, 10 um), the mobile phase had methanol and water of 80:20, the detection wavelength was 210 nm, the flow rate was 1 ml/min, and the injection volume was 20 ul.
  • the obtained hemp fiber performance indicators are shown in Table 9.
  • the raw material hemp skin processed in accordance with the production process is placed in a sulfuric acid solution having a concentration of 2 g/l, and 1 kg of hemp skin is treated with a 2 g/l sulfuric acid solution of 10 kg (i.e., a bath ratio of 1:10).
  • a sulfuric acid solution having a concentration of 2 g/l
  • 1 kg of hemp skin is treated with a 2 g/l sulfuric acid solution of 10 kg (i.e., a bath ratio of 1:10).
  • the reaction was carried out for 1 h.
  • the hemp skin was taken out from the sulfuric acid solution, and then the hemp skin was washed with tap water for 5 min.
  • the hemp skin was washed with water and then placed in an alkali cooking solution containing 7 g/L of sodium hydroxide and 6% of sodium sulfite.
  • the bath ratio is 1:10 (10 kg per kg of hemp fiber), the temperature is raised to 80 ° C in 35 min, and the temperature is kept constant for 3 h; then the hemp fiber is washed with tap water for 5 min, and the hemp fiber washed with tap water is placed in the acid solution, acid The solution contains 1 g/l of sulfuric acid. After standing for 2 min, the hemp fiber is washed with tap water for 5 min, and the hemp fiber is placed in an 8% owf pectinase solution at pH 3.5.
  • the bath ratio is 1:10 (10 kg per kg of cannabis water) ), maintain a constant temperature of 50 ° C, reaction for 8 h, remove the hemp fiber in 85 ° C hot water, let stand for 30 min, remove the hemp fiber, rinse with tap water for 5 min, dehydrate the hemp fiber, dry, soft hemp, spray cannabinol Compound suspension (same as in Example 8 Preparation method), after spraying the emulsion, the emulsion used in 1 kg of hemp fiber comprises: oil 20g, NaOH 5g, detergent 6.0g, 100g of water, sprayed the emulsion and placed in a 35 ° C constant temperature chamber, allowed to stand for 37h; After the hemp fiber is initially opened, it is fed into the carding machine, the carding machine raises the cotton board by 3 cm, and the spacing between the licker and the feeding board is 3.0 mm.
  • the method for determining the content of cannabinoids is to react specifically with phenol and FoLin-CiocaLteu reagent, and the reaction product has maximum absorption at a specific wavelength, and the absorbance value is linear with the amount of phenol in a certain concentration range.
  • a standard curve is established by using standard phenolic substances, and then the absorbance of the sample to be tested is measured, and the content of polyphenols in the sample to be tested can be obtained.
  • the content of CBD was determined by high performance liquid chromatography, and the internal standard solution was prepared with CBD reference material for making a standard curve.
  • the column used for the determination of CBD content was C 18 column (3.9 mm ⁇ 300 mm, 10 um), the mobile phase had methanol and water of 80:20, the detection wavelength was 210 nm, the flow rate was 1 ml/min, and the injection volume was 20 ul.
  • the obtained hemp fiber performance indexes are shown in Table 10.
  • Example 11 Effect of different fineness of hemp fiber on rat model of dysmenorrhea
  • the hemp fiber is prepared according to the method of the present invention, and the fabrics of the hemp fiber having a fineness of 0.1 dtex, 0.2 dtex, 1.0 dtex, 1.5 dtex, 2.0 dtex, 2.5 dtex, length 25 mm and strength 5 cN/dtex are respectively obtained. Cut into 3 ⁇ 3cm 2 small pieces for use.
  • Seventy female rats weighing 200-220 g were randomly divided into 7 groups, 10 in each group, to shave the hair on the abdomen skin.
  • the first group was a negative control group, and a patch made of 3 ⁇ 3 cm 2 cotton pieces;
  • the second group is a patch made of a fabric made of hemp fiber having a degree of closeness of 0.1 dtex, a length of 25 mm and a strength of 5 cN/dtex;
  • the third group is a patch made of a fabric made of hemp fiber having a fineness of 0.2 dtex, a length of 25 mm and a strength of 5 cN/dtex;
  • the fourth group is a patch made of a fabric made of hemp fiber having a fineness of 1.0 dtex, a length of 25 mm and a strength of 5 cN/dtex;
  • the fifth group is a patch made of a fabric made of hemp fiber having a fineness of 1.5 dtex, a length of 25 mm and a strength of 5 cN/dtex;
  • the sixth group is a patch made of a fabric made of hemp fiber having a fineness of 2.0 dtex, a length of 25 mm and a strength of 5 cN/dtex;
  • the seventh group is a patch made of a fabric made of hemp fiber having a fineness of 2.5 dtex, a length of 25 mm, and a strength of 5 cN/dtex.
  • Each group of patches was fixed with a rubber band of appropriate length, and the tape was fixed and replaced daily for 4 consecutive days.
  • Rats in each group were injected subcutaneously (sc) with diethylstilbestrol for 4 consecutive days at a daily dose of 8 mg ⁇ kg -1 to improve uterine sensitivity. After 2 hours of administration on the 4th day, the rats were intraperitoneally injected with 2 IU of oxytocin, and the uterus of the rats was contracted to induce the writhing reaction. The number of writhings of each rat in the next 40 minutes was observed and recorded, and the writhing was calculated. Incidence.
  • the incidence of writhing (%) number of writhing animals in each group / number of experimental animals in each group ⁇ 100%.
  • the patch made of the fabric woven with hemp fiber can alleviate the writhing reaction of the rat, especially the stickers of the third group, the fourth group and the fifth group.
  • the agent can significantly slow down the writhing reaction of the rat, and the patch made of hemp fiber with a fineness of 0.2 dtex, a length of 25 mm and a strength of 5 cN/dtex has a fineness of 1.0 dtex and a length of 25mm, 5cN/dtex hemp fiber woven fabric made of patch, fineness 1.5dtex, length 25mm, strength 5cN/dtex hemp fiber woven fabric made of patch has obvious Inhibition of dysmenorrhea.
  • Example 12 Effect of different lengths of hemp fiber on rat model of dysmenorrhea
  • the hemp fiber was prepared according to the method of the present invention, and a fabric made of hemp fiber having a length of 10 mm, 25 mm, 50 mm, 75 mm, a fineness of 1.0 dtex and a strength of 5 cN/dtex was cut into 3 x 3 cm 2 pieces for use.
  • Fifty female rats weighing 200-220 g were randomly divided into 5 groups, 10 in each group, and the hair on the abdomen skin was shaved.
  • the first group was a negative control group, and a patch made of 3 ⁇ 3 cm 2 cotton pieces;
  • the second group is a patch made of a fabric made of hemp fiber having a length of 10 mm, a fineness of 1.0 dtex and a strength of 5 cN/dtex;
  • the third group is a patch made of a fabric made of hemp fiber having a length of 25 mm, a fineness of 1.0 dtex and a strength of 5 cN/dtex;
  • the fourth group is a patch made of a fabric made of hemp fiber having a length of 50 mm, a fineness of 1.0 dtex and a strength of 5 cN/dtex;
  • the fifth group is a patch made of a fabric made of hemp fiber having a length of 75 mm, a fineness of 1.0 dtex, and a strength of 5 cN/dtex.
  • Each group of patches was fixed with a rubber band of appropriate length, and the tape was fixed and replaced daily for 4 consecutive days.
  • Rats in each group were injected subcutaneously (sc) with diethylstilbestrol for 4 consecutive days at a daily dose of 8 mg ⁇ kg -1 to improve uterine sensitivity. After 2 hours of administration on the 4th day, the rats were intraperitoneally injected with 2 IU of oxytocin, and the uterus of the rats was contracted to induce the writhing reaction. The number of writhings of each rat in the next 40 minutes was observed and recorded, and the writhing was calculated. Incidence.
  • the incidence of writhing (%) number of writhing animals in each group / number of experimental animals in each group ⁇ 100%.
  • the patch made of the fabric woven with hemp fiber can alleviate the writhing reaction of the rat, especially the stickers of the second group, the third group and the fourth group.
  • the agent can significantly slow down the writhing reaction of the rat, and the patch made of hemp fiber with a length of 10 mm, a fineness of 1.0 dtex and a strength of 5 cN/dtex is 25 mm in length and 1.0 in fineness.
  • Dtex a patch made of hemp fiber woven from 5cN/dtex, a patch of 50mm in length, 1.0dtex in fineness and 5cN/dtex of hemp fiber woven fabric. The inhibition of dysmenorrhea.
  • Hemp fibers were prepared in accordance with the method of the present invention, and the cannabinoids in the hemp fibers were sprayed by the method described in Example 8. Take 0.005% of the cannabinoids (including 0.001% of the CBD content of the hemp fiber), 0.01% (including the CBD content of the cannabis fiber 0.002%), 0.05% (including the CBD content of the cannabis fiber 0.004%), 0.08% (including marijuana)
  • Example 8 The method described in Example 8 was used for the methods for measuring the content of the cannabinoid compound and the CBD.
  • Fifty female rats weighing 200-220 g were randomly divided into 5 groups, 10 in each group, and the hair on the abdomen skin was shaved.
  • the first group was a negative control group, and a patch made of 3 ⁇ 3 cm 2 cotton pieces;
  • the second group is provided with a patch made of a fabric made of hemp phenolic compound 0.005%, a length of 25 mm, a fineness of 1.0 dtex, and a strength of 5 cN/dtex.
  • the third group is a patch made of a fabric made of hemp phenolic compound 0.01%, a length of 25 mm, a fineness of 1.0 dtex, and a strength of 5 cN/dtex.
  • the fourth group is a patch made of a fabric made of hemp phenolic compound 0.05%, a length of 25 mm, a fineness of 1.0 dtex, and a strength of 5 cN/dtex.
  • the fifth group was applied with a patch made of a fabric made of hemp phenolic compound 0.08%, a length of 25 mm, a fineness of 1.0 dtex, and a strength of 5 cN/dtex.
  • Each group of patches was fixed with a rubber band of appropriate length, and the tape was fixed and replaced daily for 4 consecutive days.
  • Rats in each group were injected subcutaneously (sc) with diethylstilbestrol for 4 consecutive days at a daily dose of 8 mg ⁇ kg -1 to improve uterine sensitivity. After 2 hours of administration on the 4th day, the rats were intraperitoneally injected with 2 IU of oxytocin, and the uterus of the rats was contracted to induce the writhing reaction. The number of writhings of each rat in the next 40 minutes was observed and recorded, and the writhing was calculated. Incidence.
  • the incidence of writhing (%) number of writhing animals in each group / number of experimental animals in each group ⁇ 100%.
  • the patch made of the fabric woven with hemp fiber can alleviate the writhing reaction of the rat, especially the third group, the fourth group and the fifth group.
  • the patch can significantly slow down the writhing reaction in rats, and the higher the content of cannabinol, especially the higher the content of cannabidiol, the more the patch made of hemp fiber woven fabric can significantly slow down.
  • the writhing reaction of the mouse is shown in Table 13.
  • a sanitary napkin comprising a topsheet, an absorbent inner layer and an outer layer.
  • the top layer was a fabric made of the hemp fiber prepared in Example 1
  • the absorbent inner layer was made of hemp fiber
  • the outer layer was made of a film material.
  • a sanitary napkin comprising a topsheet, an absorbent inner layer and an outer layer.
  • the top layer was a fabric made of the hemp fiber prepared in Example 2
  • the absorbent inner layer was made of hemp fiber and cotton blend
  • the outer layer was made of a film material.
  • a sanitary pad comprising a topsheet, an absorbent inner layer and an outer layer.
  • the top layer was a fabric made of the hemp fiber prepared in Example 3.
  • the absorbent inner layer was made of hemp fiber and cotton blend, and the outer layer was made of film material.
  • a sanitary napkin comprising a topsheet, an absorbent inner layer and an outer layer.
  • the top layer was a fabric made of the hemp fiber prepared in Example 10.
  • the absorbent inner layer was made of hemp fiber and cotton blend, and the outer layer was made of a film material containing hemp phenolic compound content of 0.08%.
  • Example 18 Effect of feminine hygiene products containing hemp fiber on female dysmenorrhea
  • the test time is 6 months.
  • Example 14 Example 15, Example 16 and Example 17 were effective in treating female dysmenorrhea.

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Abstract

一种用于预防和/或缓解女性痛经的大麻纤维及大麻纤维在制备具有预防和/或缓解女性痛经的女性卫生用品中用途，所述的大麻纤维的细度为0.2～2dtex，强度为1.5～8cN/dtex，长度为10～50mm，优选的，所述的大麻纤维中大麻酚类化合物的含量按质量百分比不低于0.01％，所述的大麻纤维中大麻二酚的含量按质量百分比不低于0.002％。

Description

预防和/或缓解痛经的大麻纤维及其在卫生用品中的应用 技术领域
本发明涉及一种材料，特别是涉及一种用于预防和/或缓解女性痛经的材料。
背景技术
大麻系桑科属一年生草本植物，学名cannabis Salival，俗名汉麻、寒麻、线麻、花麻等，大麻品种高达150个左右，主要分布在亚洲、欧洲，中国是亚洲大麻生产中心，栽培面积和产量居世界首位，产地遍布全国。大麻纤维具有良好的吸湿透气性能，消音吸波功能，抗静电，防紫外线辐射以及耐热、耐晒、耐腐蚀、防霉抗菌等优良性能。大麻纤维既可单纺，也可根据不同的混纺比与其它纤维混纺。
大麻纤维分子结构稳定，分子排列的取向度好，产生静电能力极低，加之吸湿性好，为低静电提供了可靠的保障，能够避免静电积聚。大麻纤维还有较高的空隙率，它有很好的吸音性和透气性，并又有很好的耐热性。大麻纤维含有木质素和半纤维素，又有特殊的表面结构和不规则的截面，因此大麻纤维对声波、光波有极好的消散作用，同时对防紫外线辐射有极好的防护效果。大麻纤维的这些特点使得大麻纤维制品具有拉伸强度高、保形性好、吸湿性好、抗菌和抗静电能力强、对染料的吸附性能好、防紫外线辐射能力强；并且大麻纤维具有较强的散湿性，锁定一定比例的水分，因此没有棉制品的初触摸时的凉意。
已报道大麻纤维中还含有大麻素、黄酮、生物碱等活性成分，具有一定的抗霉抑菌功能，大麻纤维对金黄色葡萄球菌、绿脓杆菌、大肠杆菌、白色念球菌等均有明显的杀灭作用；经高频等离子发射光谱仪分析测定，大麻纤维中含有多种对人体健康有益的微量元素，而且中空的大麻纤维，平时富含氧气，也使厌氧细菌难以生存。此外，大麻纤维还具备了柔软、卫生等更多的优势，大麻纤维两端为钝角，因而大麻织物柔软且无刺痒感。
痛经是妇科常见病和多发病，病因多，病机复杂，反复性大，治疗棘手，尤其是未婚女性及月经初期少女更为普遍，表现为经期或行经前后，周期性发生下腹部胀痛、冷痛、灼痛、刺痛、隐痛、坠痛、绞痛、痉挛性疼痛、撕裂性疼痛，疼痛延至骶腰背部，甚至涉及大腿及足部，甚至伴有全身症状，严重影响了女性的工作和学习，降低了生活的质量。
专利CN1658840A公开了给予大麻制剂的薄膜形粘膜粘性的给药剂型，其中提及了该制剂能够治疗和改善痛经，并且该制剂包括至少含有一种选自包括四氢大麻酚、大麻二酚、大麻酚和大麻色素的组。
专利CN103806153A公开了一种大麻纤维多组分混纺抑菌防臭保健纱线，由大麻纤维15～30％，芦荟粘胶纤维20～40％，羊毛纤维30～50％，羊绒纤维10～35％制成，单纱断裂强度11.9～19.8cN/tex，具有抗菌、防菌、抑菌、消炎等保健功能。
专利CN206324233U公开了一种方便女性使用的内裤，内裤本体是由前片和后片构成，所述前片和所述后片均是由第一麻纤维层、第二麻纤维层、过滤层和吸水层构成，所述第一麻纤维层和所述第二麻纤维层均采用大麻纤维制成，能抑制细菌滋生，消除炎症，天然消除异味。
专利CN102920551A公开了一种汉麻抗菌卫生巾，其利用在汉麻杆中提取汉麻纤维，将质量比为20％～0％∶80％～60％的汉麻纤维与ES纤维混合制成卫生巾用抗菌表面材料。
专利CN101831715B公开了一种具有较高的细度和强度的大麻纤维，大麻纤维细度为1500～4000公支，强度为4～10cN/dtex，可采用干法纺纱和其它纤维混纺制备各种档次的纺织产品。
专利CN106567138A公开了一种大麻纤维的精细化加工方法，包括大麻韧皮的蒸煮除杂步骤、蒸汽闪爆活化处理步骤、打饼装笼步骤、定向催化氧化步骤、化学脱胶步骤和后处理步骤；所制得的大麻纤维成品的细度2.2～3.5dtex，残胶率为2.44～3.82％，纤维强度为2.7～3.3cN/dtex，纤维的平均长度大于30mm。
专利CN101273938A、CN102090950A、CN103751471A、CN105457079A以及CN102038975A等公开了以无纺布制成的缓解及治疗痛经的卫生巾。
然而，上述专利中并没有针对女性痛经的症状设计适宜的大麻纤维及其制品。本发明通过对大麻纤维以及纤维中大麻素类化合物的控制，提供了一种对女性痛经具有良好的缓解及治疗效果的大麻纤维及其产品。
发明内容
本发明第一方面提供了一种可预防和/或缓解女性痛经的大麻纤维，所述的大麻纤维的细度为0.2～2dtex，强度为1.5～8cN/dtex，长度为10～50mm。
优选的，本发明所述的大麻纤维的细度为0.5～1.5dtex，更优选的，大麻纤维的细度为1～1.5dtex。优选的，本发明所述的大麻纤维的强度为2-6cN/dtex，更优选的，本发明所述的大麻纤维的强度为3-4.5cN/dtex。优选的，本发明所述的大麻纤维的长度为10～50mm，更优选的，本发明所述的大麻纤维的长度为10-40mm，特别优选的，本发明所述的大麻纤维的长度为10-20mm。可以理解的是，由于大麻植株中存在大麻酚类化合物，而大麻纤维制备工艺中会残留部分大麻酚类化合物，特别是大麻纤维表面以及内部空隙成为大麻酚类化合物分布的部位，而大麻纤维的细度和长度决定了大麻纤维的比表面积以及内部空隙的空间大小，因此本发明发现特定细度和强度的大麻纤维在对痛经缓解的程度存在明显的差异。另外，不同细度、强度以及长度的大麻纤维在纺织成卫生用品材料时，由于其成型后的松弛程度不同，导致成品与人体组织的接触程度变化，也会影响最终的效果。
在本发明的一个优选的实施例中，所述的大麻纤维中大麻酚类化合物的含量按质量百分比不低于0.01％，更优选，所述的大麻纤维中大麻酚类化合物的含量按质量百分比不低于0.05％，特别优选的，所述的大麻纤维中大麻酚类化合物的含量按质量百分比不低于0.08％。本领域技术人员可以理解，大麻纤维中的大麻酚类化合物可以是大麻纤维中残留的，也可以是通过制备工艺中添加入大麻酚类化合物，以使大麻纤维中达到所述的大麻酚类化合物的含量。
进一步的，所述的大麻纤维中大麻二酚的含量按质量百分比不低于0.002％，优选的，所述的大麻纤维中大麻二酚的含量按质量百分比不低于0.004％，更优选的，所述的大麻纤维中大麻二酚的含量按质量百分比不低于0.007％。本领域技术人员可以理解，大麻纤维中的大麻二酚可以是大麻纤维中残留的，也可以是通过制备工艺中添加的，以使大麻纤维中达到所述的大麻二酚的含量。
本发明第二方面提供了一种预防和/或缓解痛经的女性卫生用品，所述的女性卫生用品包括大麻纤维，所述的大麻纤维的细度为0.2～2dtex，强度为1.5～8cN/dtex，长度为10～50mm。
优选的，本发明所述的女性卫生用品为卫生巾、卫生护垫、卫生棉条。优选的，所述的女性卫生用品为卫生巾。
本发明所述的女性卫生用品中所述的大麻纤维可以是单独纺织制备，也可以是与其他纤维混合纺织制备。优选的，所述的其他纤维选自天然纤维或合成纤维，所述的天然纤维选自粘胶纤维、棉纤维、羊毛纤维和羊绒纤维，所说的合成纤维选自聚酰胺纤维、聚酯纤维、间位-芳族聚酰胺纤维、改性聚丙烯腈纤维、聚噁二唑纤维、聚丙烯腈系纤维、聚乙烯醇纤维。当本发明所述的女性卫生用品是大麻纤维与其他纤维混合纺制制备时，所述的大麻纤维与其他纤维的比例可以为1:99-99:1，优选是：30：70-70：30，特别优选是60：40-80：20。
在本发明的一个实施方式中，所述的女性卫生用品为卫生巾，所述的卫生巾包括面层、吸收内层和外层，所述的面层为由所述的大麻纤维制成的面料。在本发明的一个实施方式中，所述的吸收内层为选自大麻纤维、棉、不织布、纸浆或由大麻纤维、棉、不织布、纸浆的复合物所形成的聚合物中的一种或者几种制成，优选为大麻纤维。在本发明的一个实施方式中，所述的外层为选自大麻纤维制成的面料、无纺布或膜材料制成。
本发明的第三方面提供了一种大麻纤维在制备预防和/或缓解女性痛经的产品中的应用，所述的大麻纤维的细度为0.2～2dtex，强度为1.5～8cN/dtex，长度为10～50mm。
本领域技术人员可以理解，本发明所述的大麻纤维可以采用现有的任意的制备方法，只要是所述的方法制备得到的大麻纤维的细度为0.2～2dtex，强度为1.5～8cN/dtex，长度为10～50mm。通常的，所述的大麻纤维制备方法包括脱胶、水洗、给油、脱水、烘干。所述的脱胶 步骤包括经化学脱胶法、生物酶脱胶法、物理脱胶法，所述的大麻纤维也可以是由化学脱胶法与生物酶脱胶法相结合，或者是由化学脱胶法与物理脱胶法相结合，或者是由生物酶脱胶法与物理脱胶法相结合，或者是由化学脱胶法、生物酶脱胶法与物理脱胶法三种方法相结合制备得到的。
在本发明的一个具体实施方式中，所述的大麻纤维的制备方法包括脱胶、水洗、给油、脱水、烘干，所述的制备方法中还包括向大麻纤维中添加大麻酚类化合物的步骤。优选的，所述的向大麻纤维中添加大麻酚类化合物的步骤为在给油前添加大麻酚类化合物，或者，在给油后添加大麻酚类化合物。更优选的，所述的添加方式选自注射加入、喷涂加入、溶液混合等方式。本领域技术人员可以理解，所述的大麻酚类化合物的加入时间和加入方式可以任意选择，只要保证所述的大麻纤维中大麻酚类化合物的含量按质量百分比不低于0.01％，优选的，所述的大麻纤维中大麻酚类化合物的含量按质量百分比不低于0.05％，特别优选的，所述的大麻纤维中大麻酚类化合物的含量按质量百分比不低于0.08％。
本发明所述的大麻酚类化合物选自大麻酚、大麻二酚、四氢大麻酚、次大麻二酚、四氢次大麻酚、大麻酚酸、大麻二酚酸中的一种或两种以上的组合。优选的，所述的大麻酚类化合物为大麻二酚。
更优选的，所述的大麻纤维中大麻二酚的含量按质量百分比不低于0.002％，优选的，所述的大麻纤维中大麻二酚的含量按质量百分比不低于0.004％，更优选的，所述的大麻纤维中大麻二酚的含量按质量百分比不低于0.007％。同样的，本领域技术人员可以理解，大麻纤维中的大麻二酚可以是大麻纤维中残留的，也可以是通过制备工艺中添加的，以使大麻纤维中达到所述的大麻二酚的含量。
本发明所述向大麻纤维中添加的大麻酚类化合物是从大麻植株中提取得到的，所述大麻植株提取部位优选为大麻籽、大麻叶、大麻花、大麻秆芯、大麻根中的一种或任意两种及以上以任意比例的组合。
进一步地，所述大麻酚类化合物可以是将大麻植株不同的植物部位分别提取后组合，如大麻花提取得到的大麻酚类化合物与大麻叶提取得到的大麻酚类化合物；大麻秆芯提取得到的大麻酚类化合物、大麻花提取得到的大麻酚类化合物与大麻叶提取得到的大麻酚类化合物等组合形式。所述大麻酚类化合物也可以是将大麻植株不同的植物部位组合后同时提取，如大麻花与叶提取得到的大麻酚类化合物；大麻秆芯与花、叶提取得到的大麻酚类化合物；大麻秆芯和花提取得到的大麻酚类化合物；大麻秆芯和叶提取得到的大麻酚类化合物；大麻花、叶提取得到的大麻酚类化合物与大麻叶、秆芯提取得到的大麻酚类化合物的组合等形式。
本发明所述的大麻酚类化合物可采用现有技术中常规的植物提取方法来制备，如溶 剂提取法、水蒸气蒸馏法、升华法、超临界流体萃取、膜提取分离技术等等；优选的，可采用溶剂提取法，提取溶剂可为：低分子醇(如甲醇、乙醇、丁醇或者丙醇)、乙酸酯(如乙酸甲酯或者乙酸乙酯)、酮(如丙酮)、醚(如甲醚或者乙醚)、低沸点的脂肪烃或者芳香烃或者氯化烃等；提取的工艺可为加热回流，还可结合其他提取分离方式如萃取、蒸馏、结晶、色谱分离等中的一种或多种的组合对提取物进行进一步的提纯分离。
本发明的第四方面，涉及一种预防和/或缓解痛经的方法，所述的方法包括施用含有大麻纤维的女性卫生用品，所述的大麻纤维的细度为0.2～2dtex，强度为1.5～8cN/dtex，长度为10～50mm。
优选的，所述的大麻纤维中大麻酚类化合物的含量按质量百分比不低于0.01％。
本发明提供的大麻纤维与女性卫生用品可有效的预防和缓解女性痛经，为缓解与治疗女性痛经提供了新思路。
本发明所述的术语“治疗”包括抑制、延迟、缓和、减弱、限制、减轻或消退疾病、障碍、病症或状态，其发生和/或进程，和/或其症状。
本发明所述的术语“预防”包括减小以下风险：患有、感染或经历疾病、障碍、病症或状态，其发生和/或进程，和/或其症状。
本发明所述的术语“包含”表示"开放"或"包含性"用语，使得它们包括列举的要素，而且还允许包括额外的、未提及的要素。
本发明所述的术语“约”通常意指所述值的+/-5％，更通常指所述值的+/-4％，更通常指所述值的+/-3％，更通常指所述值的+/-2％，更通常指所述值的+/-1％，更通常指所述值的+/-0.5％。
具体实施方式
实施例1大麻纤维的制备
经过备料工序处理过的符合生产需要的原料大麻皮放入氧化液中，1公斤大麻皮用水10公斤(即浴比为1∶10)，氧化液中包含双氧水(纯H 2O 2的量)10g/L、三聚磷酸钠3g/L、尿素2g/L。将氧化液的温度在30min匀速升至90℃，恒温保持1h；氧化过的大麻皮经自来水冲洗后放入碱煮液中，碱煮液中包含氢氧化钠7g/L、三聚磷酸钠1.5g/L、尿素2g/L，浴比为1∶10(每公斤大麻皮用水10公斤)，35min升温至80℃，恒温保持4h；将经过碱煮后的大麻纤维放入后处理液中，后处理液中纤维膨松剂(膨松剂BK-100与尿素2∶1混合)含量为4g/L，后处理液与大麻纤维的浴比为1∶10，后处理的温度为60℃，反应60min。
对后处理后的大麻纤维打击8次后，用自来水冲洗大麻纤维，以去除纤维表面残留的药 品和杂质。将大麻纤维脱水，浸泡于乳化油中，1公斤大麻纤维使用的乳化油中包含机械油30g、NaOH 5g、洗涤剂10g、水10公斤，在90℃的环境下保温1h。从乳化油中取出大麻纤维，脱水，烘干，软麻，喷涂乳化液，1公斤大麻纤维使用的乳化液中包含：油15g、NaOH6g、洗涤剂7.5g、水100g，喷涂乳化液之后置入35℃恒温仓中，静置37h；对大麻纤维初步开松后，喂入梳棉机中，梳棉机给棉板抬高3cm，刺辊与给棉板隔距采用3.0mm。得到的大麻纤维性能指标如表1所示。
表1
Figure PCTCN2018100840-appb-000001
实施例2大麻纤维的制备
经过备料工序处理过的符合生产需要的原料大麻皮放入氧化液中，1公斤大麻皮用水10公斤(即浴比为1∶10)，氧化液中包含双氧水(纯H 2O 2的量)8g/L、三聚磷酸钠2g/L、尿素2g/L。将氧化液的温度在30min匀速升至90℃，恒温保持1h；氧化过的大麻皮经自来水冲洗后放入碱煮液中，碱煮液中包含氢氧化钠6g/L、三聚磷酸钠1.5g/L、尿素2g/L，浴比为1∶10(每公斤大麻皮用水10公斤)，35min升温至80℃，恒温保持4h；将经过碱煮后的大麻纤维放入后处理液中，后处理液中纤维膨松剂(膨松剂BK-100与尿素2∶1混合)含量为4g/L，后处理液与大麻纤维的浴比为1∶10，后处理的温度为55℃，反应60min。
对后处理后的大麻纤维打击8次后，用自来水冲洗大麻纤维，以去除纤维表面残留的药品和杂质。将大麻纤维脱水，浸泡于乳化油中，1公斤大麻纤维使用的乳化油中包含机械油10g、NaOH 5g、洗涤剂10g、水10公斤，在90℃的环境下保温1h。从乳化油中取出大麻纤维，脱水，烘干，软麻，喷涂乳化液，1公斤大麻纤维使用的乳化液中包含：油15g、NaOH6g、洗涤剂7.5g、水100g，喷涂乳化液之后置入35℃恒温仓中，静置37h；对大麻纤维初步开松后，喂入梳棉机中，梳棉机给棉板抬高2cm，刺辊与给棉板隔距采用2.0mm。得到的大麻纤维性能指标如表2所示。
表2
Figure PCTCN2018100840-appb-000002
实施例3大麻纤维的制备
经过备料工序处理过的符合生产需要的原料大麻皮放入氧化液中，1公斤大麻皮用水10公斤(即浴比为1∶10)，氧化液中包含双氧水(纯H 2O 2的量)12g/L、三聚磷酸钠3g/L。将氧化液的温度在30min匀速升至90℃，恒温保持1h；氧化过的大麻皮经自来水冲洗后放入碱煮液 中，碱煮液中包含氢氧化钠8g/L、三聚磷酸钠1.5g/L、尿素2g/L，浴比为1∶10(每公斤大麻皮用水10公斤)，35min升温至80℃，恒温保持4h；将经过碱煮后的大麻纤维放入后处理液中，后处理液中纤维膨松剂(膨松剂BK-100与尿素2∶1混合)含量为4g/L，后处理液与大麻纤维的浴比为1∶10，后处理的温度为60℃，反应60min。
对后处理后的大麻纤维打击8次后，用自来水冲洗大麻纤维，以去除纤维表面残留的药品和杂质。将大麻纤维脱水，浸泡于乳化油中，1公斤大麻纤维使用的乳化油中包含机械油15g、NaOH 2g、洗涤剂10g、水10公斤，在90℃的环境下保温1h。从乳化油中取出大麻纤维，脱水，烘干，软麻，喷涂乳化液，1公斤大麻纤维使用的乳化液中包含：油18g、NaOH4g、洗涤剂7.5g、水100g，喷涂乳化液之后置入35℃恒温仓中，静置37h；对大麻纤维初步开松后，喂入梳棉机中，梳棉机给棉板抬高4cm，刺辊与给棉板隔距采用4.0mm。得到的大麻纤维性能指标如表3所示。
表3
Figure PCTCN2018100840-appb-000003
实施例4大麻纤维的制备
经过备料工序处理过的符合生产需要的原料大麻皮放入氧化液中，1公斤大麻皮用水10公斤(即浴比为1∶10)，氧化液中包含双氧水(纯H 2O 2的量)10g/L、三聚磷酸钠3g/L、尿素2g/L。将氧化液的温度在30min匀速升至100℃，恒温保持2h；氧化过的大麻皮经自来水冲洗后放入碱煮液中，碱煮液中包含氢氧化钠6g/L、三聚磷酸钠2g/L、尿素3g/L，浴比为1∶10(每公斤大麻皮用水10公斤)，35min升温至80℃，恒温保持4h；将经过碱煮后的大麻纤维放入后处理液中，后处理液中纤维膨松剂(膨松剂BK-100与尿素2∶1混合)含量为4g/L，后处理液与大麻纤维的浴比为1∶10，后处理的温度为60℃，反应60min。
对后处理后的大麻纤维打击8次后，用自来水冲洗大麻纤维，以去除纤维表面残留的药品和杂质。将大麻纤维脱水，浸泡于乳化油中，1公斤大麻纤维使用的乳化油中包含机械油20g、NaOH 5g、洗涤剂10g、水10公斤，在90℃的环境下保温1h。从乳化油中取出大麻纤维，脱水，烘干，软麻，喷涂乳化液，1公斤大麻纤维使用的乳化液中包含：油20g、NaOH2g、洗涤剂7.5g、水100g，喷涂乳化液之后置入35℃恒温仓中，静置37h；对大麻纤维初步开松后，喂入梳棉机中，梳棉机给棉板抬高5cm，刺辊与给棉板隔距采用2.0mm。得到的大麻纤维性能指标如表4所示。
表4
Figure PCTCN2018100840-appb-000004
Figure PCTCN2018100840-appb-000005
实施例5大麻纤维的制备
经过备料工序处理过的符合生产需要的原料大麻皮放入浓度为2g/l的硫酸溶液中，1公斤大麻皮用2g/l的硫酸溶液10公斤(即浴比为1∶10)，保持恒温50℃，反应1h，从硫酸溶液中取出大麻皮，然后用自来水冲洗大麻皮5min，大麻皮经水洗后再放入碱煮液中，碱煮液中包含氢氧化钠7g/L、亚硫酸钠3％、磷酸三钠5％，浴比为1∶10(每公斤大麻纤维用水10公斤)，35min升温至80℃，保持恒温3h；然后用自来水冲洗大麻纤维5min，再将经自来水冲洗的大麻纤维放入酸溶液中，酸溶液中包含硫酸1g/l，静置2min后用自来水冲洗大麻纤维5min，将大麻纤维置于pH3.5的8％o.w.f果胶酶溶液中，浴比为1∶10(每公斤大麻用水10公斤)，维持恒温50℃，反应8h，将大麻纤维取出置于85℃热水中，静置30min，取出大麻纤维，用自来水冲洗5min，将大麻纤维脱水，烘干，软麻，喷涂乳化液，1公斤大麻纤维使用的乳化液中包含：油15g、NaOH6g、洗涤剂7.5g、100g的水，喷涂乳化液之后置入35℃恒温仓中，静置37h；对大麻纤维初步开松后，喂入梳棉机中，梳棉机给棉板抬高3cm，刺辊与给棉板隔距采用3.0mm。得到的大麻纤维性能指标如表5所示。
表5
Figure PCTCN2018100840-appb-000006
实施例6大麻纤维的制备
经过备料工序处理过的符合生产需要的原料大麻皮放入浓度为2g/l的硫酸溶液中，1公斤大麻皮用2g/l的硫酸溶液10公斤(即浴比为1∶10)，保持恒温50℃，反应1h，从硫酸溶液中取出大麻皮，然后用自来水冲洗大麻皮5min，大麻皮经水洗后再放入碱煮液中，碱煮液中包含氢氧化钠10g/L、亚硫酸钠2％、磷酸三钠3％，浴比为1∶10(每公斤大麻纤维用水10公斤)，35min升温至80℃，保持恒温3h；然后用自来水冲洗大麻纤维5min，再将经自来水冲洗的大麻纤维放入酸溶液中，酸溶液中包含硫酸1g/l，静置2min后用自来水冲洗大麻纤维5min，将大麻纤维置于pH3.5的10％o.w.f果胶酶溶液中，浴比为1∶10(每公斤大麻用水10公斤)，维持恒温50℃，反应8h，将大麻纤维取出置于85℃热水中，静置30min，取出大麻纤维，用自来水冲洗5min，将大麻纤维脱水，烘干，软麻，喷涂乳化液，1公斤大麻纤维使用的乳化液中包含：油15g、NaOH8g、洗涤剂7.5g、100g的水，喷涂乳化液之后置入35℃恒温仓中，静置37h；对大麻纤维初步开松后，喂入梳棉机中，梳棉机给棉板抬高3cm，刺辊与给棉板隔距采用3.0mm。得到的大麻纤维性能指标如表6所示。
表6
Figure PCTCN2018100840-appb-000007
实施例7大麻纤维的制备
经过备料工序处理过的符合生产需要的原料大麻皮放入浓度为2g/l的硫酸溶液中，1公斤大麻皮用3g/l的硫酸溶液10公斤(即浴比为1∶10)，保持恒温50℃，反应1h，从硫酸溶液中取出大麻皮，然后用自来水冲洗大麻皮5min，大麻皮经水洗后再放入碱煮液中，碱煮液中包含氢氧化钠10g/L、亚硫酸钠2％、磷酸三钠5％，浴比为1∶10(每公斤大麻纤维用水10公斤)，35min升温至80℃，保持恒温3h；然后用自来水冲洗大麻纤维5min，再将经自来水冲洗的大麻纤维放入酸溶液中，酸溶液中包含硫酸1g/l，静置2min后用自来水冲洗大麻纤维5min，将大麻纤维置于pH4的8％o.w.f果胶酶溶液中，浴比为1∶10(每公斤大麻用水10公斤)，维持恒温50℃，反应8h，将大麻纤维取出置于85℃热水中，静置30min，取出大麻纤维，用自来水冲洗5min，将大麻纤维脱水，烘干，软麻，喷涂乳化液，1公斤大麻纤维使用的乳化液中包含：油30g、NaOH6g、洗涤剂7.5g、100g的水，喷涂乳化液之后置入35℃恒温仓中，静置37h；对大麻纤维初步开松后，喂入梳棉机中，梳棉机给棉板抬高2cm，刺辊与给棉板隔距采用5.0mm。得到的大麻纤维性能指标如表7所示。
表7
Figure PCTCN2018100840-appb-000008
实施例8大麻纤维的制备
经过备料工序处理过的符合生产需要的原料大麻皮放入浓度为2g/l的硫酸溶液中，1公斤大麻皮用2g/l的硫酸溶液10公斤(即浴比为1∶10)，保持恒温50℃，反应1h，从硫酸溶液中取出大麻皮，然后用自来水冲洗大麻皮5min，大麻皮经水洗后再放入碱煮液中，碱煮液中包含氢氧化钠7g/L、亚硫酸钠6％，浴比为1∶10(每公斤大麻纤维用水10公斤)，35min升温至80℃，保持恒温3h；然后用自来水冲洗大麻纤维5min，再将经自来水冲洗的大麻纤维放入酸溶液中，酸溶液中包含硫酸1g/l，静置2min后用自来水冲洗大麻纤维5min，将大麻纤维置于pH3.5的8％o.w.f果胶酶溶液中，浴比为1∶10(每公斤大麻用水10公斤)，维持恒温50℃，反应8h，将大麻纤维取出置于85℃热水中，静置30min，取出大麻纤维，用自来水冲洗5min，将大麻纤维脱水，烘干，软麻，喷涂大麻酚类化合物混悬液，之后喷涂乳化液，1公斤大麻纤维使用的乳化液中包含：油30g、NaOH7g、洗涤剂9g、100g的水，喷涂乳化液之后置入35℃恒温仓中，静置37h；对大麻纤维初步开松后，喂入梳棉机中，梳棉机给棉板抬高3cm，刺辊与给棉板隔距采用3.0mm。
大麻酚类化合物混悬液的制备方法为：将大麻叶干燥、粉碎，过筛；将所得粉末，用8倍量、50％的乙醇冷浸提取2次，每次1.5小时；合并提取液，经活性炭吸附脱色；70℃温度条件下，减压浓缩至相对密度1.02，得到提取物浸膏，其中提取物浸膏中大麻酚类化合物含量为45％，而大麻酚类化合物中大麻二酚的含量为92％，加入适宜溶剂制备成混悬液使用。
大麻酚类化合物的含量测定方法采用酚与FoLin-CiocaLteu试剂发生特异性反应，反应产物对特定波长有最大吸收，且吸光值与酚的量在一定浓度范围内成线性关系。先以标准酚类物质建立标准曲线，再测定待测样品吸光值，据此可求出待测样品中多酚的含量。
CBD的含量采用高效液相色谱法测定，以CBD对照品配制内标溶液以供制作标准曲线。CBD含量测定所用色谱柱为C 18柱(3.9mm×300mm，10um)，流动相中甲醇与水为80:20，检测波长为210nm，流速为1ml/min，进样量为20ul。得到的大麻纤维性能指标如表8所示。
表8
Figure PCTCN2018100840-appb-000009
实施例9大麻纤维的制备
经过备料工序处理过的符合生产需要的原料大麻皮放入浓度为2g/l的硫酸溶液中，1公斤大麻皮用2g/l的硫酸溶液10公斤(即浴比为1∶10)，保持恒温50℃，反应1h，从硫酸溶液中取出大麻皮，然后用自来水冲洗大麻皮5min，大麻皮经水洗后再放入碱煮液中，碱煮液中包含氢氧化钠7g/L、亚硫酸钠6％，浴比为1∶10(每公斤大麻纤维用水10公斤)，35min升温至80℃，保持恒温3h；然后用自来水冲洗大麻纤维5min，再将经自来水冲洗的大麻纤维放入酸溶液中，酸溶液中包含硫酸1g/l，静置2min后用自来水冲洗大麻纤维5min，将大麻纤维置于pH3.5的8％o.w.f果胶酶溶液中，浴比为1∶10(每公斤大麻用水10公斤)，维持恒温50℃，反应8h，将大麻纤维取出置于85℃热水中，静置30min，取出大麻纤维，用自来水冲洗5min，将大麻纤维脱水，烘干，软麻，喷涂大麻酚类化合物混悬液(同实施例8的制备方法)，之后喷涂乳化液，1公斤大麻纤维使用的乳化液中包含：油255g、NaOH6.5g、洗涤剂8.5g、100g的水，喷涂乳化液之后置入35℃恒温仓中，静置37h；对大麻纤维初步开松后，喂入梳棉机中，梳棉机给棉板抬高3cm，刺辊与给棉板隔距采用3.0mm。
大麻酚类化合物的含量测定方法采用酚与FoLin-CiocaLteu试剂发生特异性反应，反应产物对特定波长有最大吸收，且吸光值与酚的量在一定浓度范围内成线性关系。先以标准酚类物质建立标准曲线，再测定待测样品吸光值，据此可求出待测样品中多酚的含量。
CBD的含量采用高效液相色谱法测定，以CBD对照品配制内标溶液以供制作标准曲线。CBD含量测定所用色谱柱为C 18柱(3.9mm×300mm，10um)，流动相中甲醇与水为80:20， 检测波长为210nm，流速为1ml/min，进样量为20ul。得到的大麻纤维性能指标如表9所示。
表9
Figure PCTCN2018100840-appb-000010
实施例10大麻纤维的制备
经过备料工序处理过的符合生产需要的原料大麻皮放入浓度为2g/l的硫酸溶液中，1公斤大麻皮用2g/l的硫酸溶液10公斤(即浴比为1∶10)，保持恒温50℃，反应1h，从硫酸溶液中取出大麻皮，然后用自来水冲洗大麻皮5min，大麻皮经水洗后再放入碱煮液中，碱煮液中包含氢氧化钠7g/L、亚硫酸钠6％，浴比为1∶10(每公斤大麻纤维用水10公斤)，35min升温至80℃，保持恒温3h；然后用自来水冲洗大麻纤维5min，再将经自来水冲洗的大麻纤维放入酸溶液中，酸溶液中包含硫酸1g/l，静置2min后用自来水冲洗大麻纤维5min，将大麻纤维置于pH3.5的8％o.w.f果胶酶溶液中，浴比为1∶10(每公斤大麻用水10公斤)，维持恒温50℃，反应8h，将大麻纤维取出置于85℃热水中，静置30min，取出大麻纤维，用自来水冲洗5min，将大麻纤维脱水，烘干，软麻，喷涂大麻酚类化合物混悬液(同实施例8的制备方法)，之后喷涂乳化液，1公斤大麻纤维使用的乳化液中包含：油20g、NaOH5g、洗涤剂6.0g、100g的水，喷涂乳化液之后置入35℃恒温仓中，静置37h；对大麻纤维初步开松后，喂入梳棉机中，梳棉机给棉板抬高3cm，刺辊与给棉板隔距采用3.0mm。
大麻酚类化合物的含量测定方法采用酚与FoLin-CiocaLteu试剂发生特异性反应，反应产物对特定波长有最大吸收，且吸光值与酚的量在一定浓度范围内成线性关系。先以标准酚类物质建立标准曲线，再测定待测样品吸光值，据此可求出待测样品中多酚的含量。
CBD的含量采用高效液相色谱法测定，以CBD对照品配制内标溶液以供制作标准曲线。CBD含量测定所用色谱柱为C 18柱(3.9mm×300mm，10um)，流动相中甲醇与水为80:20，检测波长为210nm，流速为1ml/min，进样量为20ul。得到的大麻纤维性能指标如表10所示。
表10
Figure PCTCN2018100840-appb-000011
实施例11不同细度的大麻纤维对痛经大鼠模型的影响试验
试验样品：
按照本发明的方法制备大麻纤维，取细度分别为0.1dtex、0.2dtex、1.0dtex、1.5dtex、2.0dtex、2.5dtex，长度为25mm，强度为5cN/dtex的大麻纤维纺织成的面料，分别裁成3×3cm 2的小片备用。
试验动物：
由北京梅里亚维通实验动物技术有限公司提供的200-220g的雌性大鼠。
试验方法：
将70只体重为200-220g的雌性大鼠随机分为7组，每组10只，剃除腹部皮肤上的毛。
第一组为阴性对照组，以3×3cm 2的棉布小片制成的贴剂；
第二组在腹部贴细度为0.1dtex，长度为25mm，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂；
第三组在腹部贴细度为0.2dtex，长度为25mm，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂；
第四组在腹部贴细度为1.0dtex，长度为25mm，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂；
第五组在腹部贴细度为1.5dtex，长度为25mm，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂；
第六组在腹部贴细度为2.0dtex，长度为25mm，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂；
第七组在腹部贴细度为2.5dtex，长度为25mm，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂。
各组贴剂分别以长度合适的橡皮筋捆扎胸部固定，胶布固定，每日更换，连续4天。
各组大鼠分别皮下注射(sc)乙烯雌酚，连续4天，每天剂量为8mg·kg -1，以提高子宫敏感度。各组再于第4天给药2h后腹腔注射缩宫素2IU/只，使大鼠子宫收缩，诱发其扭体反应，观察并记录随后40min内每只大鼠的扭体次数，计算扭体发生率。
扭体发生率(％)＝各组发生扭体动物数/各组试验动物数×100％。
表11
Figure PCTCN2018100840-appb-000012
Figure PCTCN2018100840-appb-000013
试验结果：
如表11所示，与阴性对照组相比，贴大麻纤维纺织成的面料制成的贴剂均能减缓大鼠的扭体反应，尤其是第三组、第四组、第五组的贴剂更能显著的减缓大鼠的扭体反应，说明细度为0.2dtex，长度为25mm，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂，细度为1.0dtex，长度为25mm，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂，细度为1.5dtex，长度为25mm，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂有明显的抑制痛经作用。
实施例12不同长度的大麻纤维对痛经大鼠模型的影响试验
试验样品：
按照本发明的方法制备大麻纤维，取长度分别为10mm、25mm、50mm、75mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料，裁成3×3cm 2的小片备用。
试验动物：
由北京梅里亚维通实验动物技术有限公司提供的200-220g的雌性大鼠。
试验方法：
将50只体重为200-220g的雌性大鼠随机分为5组，每组10只，剃除腹部皮肤上的毛。
第一组为阴性对照组，以3×3cm 2的棉布小片制成的贴剂；
第二组在腹部贴长度为10mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂；
第三组在腹部贴长度为25mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂；
第四组在腹部贴长度为50mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂；
第五组在腹部贴长度为75mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂。
各组贴剂分别以长度合适的橡皮筋捆扎胸部固定，胶布固定，每日更换，连续4天。
各组大鼠分别皮下注射(sc)乙烯雌酚，连续4天，每天剂量为8mg·kg -1，以提高子宫敏感度。各组再于第4天给药2h后腹腔注射缩宫素2IU/只，使大鼠子宫收缩，诱发其扭体反应，观察并记录随后40min内每只大鼠的扭体次数，计算扭体发生率。
扭体发生率(％)＝各组发生扭体动物数/各组试验动物数×100％。
表12
Figure PCTCN2018100840-appb-000014
Figure PCTCN2018100840-appb-000015
试验结果：
如表12所示，与阴性对照组相比，贴大麻纤维纺织成的面料制成的贴剂均能减缓大鼠的扭体反应，尤其是第二组、第三组、第四组的贴剂更能显著的减缓大鼠的扭体反应，说明长度为10mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂，长度为25mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂，长度为50mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂，有明显的抑制痛经作用。
实施例13含有不同大麻酚类物质的大麻纤维对痛经大鼠模型的影响试验
试验样品：
按照本发明的方法制备大麻纤维，大麻纤维中大麻酚类化合物采用实施例8所述方法喷涂加入。取含有大麻酚类化合物0.005％(其中大麻纤维中CBD含量0.001％)、0.01％(其中大麻纤维中CBD含量0.002％)、0.05％(其中大麻纤维中CBD含量0.004％)、0.08％(其中大麻纤维中CBD含量0.008％)，长度为25mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料，裁成3×3cm 2的小片备用。
大麻酚类化合物和CBD的含量测定方法均采用实施例8所记载的方法。
试验动物：
由北京梅里亚维通实验动物技术有限公司提供的200-220g的雌性大鼠。
试验方法：
将50只体重为200-220g的雌性大鼠随机分为5组，每组10只，剃除腹部皮肤上的毛。
第一组为阴性对照组，以3×3cm 2的棉布小片制成的贴剂；
第二组在腹部贴含有大麻酚类化合物0.005％，长度为25mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂；
第三组在腹部贴含有大麻酚类化合物0.01％，长度为25mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂；
第四组在腹部贴含有大麻酚类化合物0.05％，长度为25mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂；
第五组在腹部贴含有大麻酚类化合物0.08％，长度为25mm，细度为1.0dtex，强度为5cN/dtex的大麻纤维纺织成的面料制成的贴剂。
各组贴剂分别以长度合适的橡皮筋捆扎胸部固定，胶布固定，每日更换，连续4天。
各组大鼠分别皮下注射(sc)乙烯雌酚，连续4天，每天剂量为8mg·kg -1，以提高子宫敏感度。各组再于第4天给药2h后腹腔注射缩宫素2IU/只，使大鼠子宫收缩，诱发其扭体反应，观察并记录随后40min内每只大鼠的扭体次数，计算扭体发生率。
扭体发生率(％)＝各组发生扭体动物数/各组试验动物数×100％。
表13
Figure PCTCN2018100840-appb-000016
试验结果：
结果如表13所示，与阴性对照组相比，贴大麻纤维纺织成的面料制成的贴剂均能减缓大鼠的扭体反应，尤其是第三组、第四组与第五组的贴剂更能显著的减缓大鼠的扭体反应，并且大麻酚的含量越高的，特别是大麻二酚的含量越高，大麻纤维纺织成的面料制成的贴剂越能显著的减缓大鼠的扭体反应。
实施例14
一种卫生巾，包括面层、吸收内层和外层。面层为由实施例1制备得到的大麻纤维制成的面料，吸收内层由大麻纤维制成，外层由膜材料制成。
实施例15
一种卫生巾，包括面层、吸收内层和外层。面层为由实施例2制备得到的大麻纤维制成的面料，吸收内层由大麻纤维与棉混纺制成，外层由膜材料制成。
实施例16
一种卫生护垫，包括面层、吸收内层和外层。面层为由实施例3制备得到的大麻纤维制成的面料，吸收内层由大麻纤维与棉混纺制成，外层由膜材料制成。
实施例17
一种卫生巾，包括面层、吸收内层和外层。面层为由实施例10制备得到的大麻纤维制成的面料，吸收内层由大麻纤维与棉混纺制成，外层由膜材料制成，大麻纤维中含有大麻酚类 化合物含量为0.08％。
实施例18含有大麻纤维的女性卫生用品对女性痛经的影响试验
试验材料：
实施例14、实施例15、实施例16、实施例17制成的卫生用品。
试验方法：
招募50名20岁到30岁的女性痛经患者，随机分为5组，每组10人，第一组患者使用普通市售无治疗效果的卫生巾，第二组患者使用实施例14中所述的产品，第三组患者使用实施例15中所述的产品，第四组患者使用实施例16中所述的产品，第五组患者使用实施例17中所述的产品。试验时间为6个月。
试验标准：
分别于试验前和6个月试验期后，按照表14所示的痛经程度自测表对患者进行随访，并对结果进行统计。
表14痛经程度自测表
Figure PCTCN2018100840-appb-000017
试验结果：
从表15可以看出，实施例14、实施例15、实施例16与实施例17的产品均可有效的治疗女性痛经。
表15大麻纤维制成的卫生用品对女性痛经的影响
Figure PCTCN2018100840-appb-000018
Figure PCTCN2018100840-appb-000019
上述实施例不以任何方式限制本发明，凡是采用等同替换或等效变换的方式获得的技术方案均落在本发明的保护范围内。

Claims (15)

  1. 一种用于预防和/或缓解女性痛经的大麻纤维，其特征在于，所述的大麻纤维的细度为0.2～2dtex，强度为1.5～8cN/dtex，长度为10～50mm。
  2. 权利要求1所述的用于预防和/或缓解女性痛经的大麻纤维，其特征在于，所述的大麻纤维的细度为0.5～1.5dtex，所述的大麻纤维的强度为2-6cN/dtex，所述的大麻纤维的长度为10～50mm。
  3. 权利要求1所述的用于预防和/或缓解女性痛经的大麻纤维，其特征在于，所述的大麻纤维中大麻酚类化合物的含量按质量百分比不低于0.01％。
  4. 根据权利要求3所述的用于预防和/或缓解女性痛经的大麻纤维，其特征在于，所述的大麻纤维中大麻二酚的含量按质量百分比不低于0.002％。
  5. 根据权利要求4所述的用于预防和/或缓解女性痛经的大麻纤维，其特征在于，所述的大麻纤维中大麻二酚的含量按质量百分比不低于0.004％。
  6. 根据权利要求5所述的用于预防和/或缓解女性痛经的大麻纤维，其特征在于，所述的大麻纤维中大麻二酚的含量按质量百分比不低于0.007％。
  7. 一种预防和/或缓解痛经的女性卫生用品，其特征在于，所述的女性卫生用品包括大麻纤维，所述的大麻纤维的细度为0.2～2dtex，强度为1.5～8cN/dtex，长度为10～50mm。
  8. 权利要求7所述的一种预防和/或缓解痛经的女性卫生用品，其特征在于，所述的女性卫生用品为卫生巾、卫生护垫或卫生棉条。
  9. 权利要求7所述的一种预防和/或缓解痛经的女性卫生用品，其特征在于，所述的女性卫生用品是大麻纤维与其他纤维混合纺织制备，所述的其他纤维选自天然纤维或合成纤维。
  10. 权利要求7所述的一种预防和/或缓解痛经的女性卫生用品，其特征在于，所述的女性卫生用品为卫生巾，所述的卫生巾包括面层、吸收内层和外层，所述的面层为由大麻纤维制成。
  11. 大麻纤维在制备预防和/或缓解女性痛经的产品中的应用，其特征在于，所述的大麻纤维的细度为0.2～2dtex，强度为1.5～8cN/dtex，长度为10～50mm。
  12. 根据权利要求1所述的一种用于预防和/或缓解女性痛经的大麻纤维的制备方法，其特征在于，所述的大麻纤维制备方法包括脱胶、水洗、给油、脱水、烘干，所述的脱胶步骤选自化学脱胶法、生物酶脱胶法、物理脱胶法中的一种或两种以上的组合。
  13. 权利要求12所述的大麻纤维的制备方法，其特征在于，所述的制备方法中还包括向大麻纤维中添加大麻酚类化合物的步骤，所述的向大麻纤维中添加大麻酚类化合物的步骤选自在给油前添加大麻酚类化合物，或者，在给油后添加大麻酚类化合物。
  14. 一种预防和/或缓解痛经的方法，其特征在于，所述的方法包括施用含有大麻纤维的女性卫生用品，所述的大麻纤维的细度为0.2～2dtex，强度为1.5～8cN/dtex，长度为10～50mm。
  15. 权利要求14所述的预防和/或缓解痛经的方法，其特征在于，所述的大麻纤维中大麻酚类化合物的含量按质量百分比不低于0.01％。
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