WO2019027267A3 - Atp 포스포리보실 전이효소 변이체 및 이를 이용한 l-히스티딘 생산방법 - Google Patents

Atp 포스포리보실 전이효소 변이체 및 이를 이용한 l-히스티딘 생산방법 Download PDF

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WO2019027267A3
WO2019027267A3 PCT/KR2018/008778 KR2018008778W WO2019027267A3 WO 2019027267 A3 WO2019027267 A3 WO 2019027267A3 KR 2018008778 W KR2018008778 W KR 2018008778W WO 2019027267 A3 WO2019027267 A3 WO 2019027267A3
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WIPO (PCT)
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same
production method
atp phosphoribosyltransferase
histidine production
phosphoribosyltransferase mutant
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PCT/KR2018/008778
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English (en)
French (fr)
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WO2019027267A2 (ko
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박명근
권나라
이진남
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씨제이제일제당 (주)
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Priority to US16/635,359 priority Critical patent/US11098333B2/en
Priority to EP18841909.7A priority patent/EP3647417A4/en
Priority to CA3071280A priority patent/CA3071280C/en
Priority to JP2020503268A priority patent/JP6789436B2/ja
Priority to AU2018310134A priority patent/AU2018310134B2/en
Priority to BR112020001762-0A priority patent/BR112020001762B1/pt
Priority to CN201880049259.1A priority patent/CN111315876B/zh
Publication of WO2019027267A2 publication Critical patent/WO2019027267A2/ko
Publication of WO2019027267A3 publication Critical patent/WO2019027267A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02017—ATP phosphoribosyltransferase (2.4.2.17)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

본 출원은 ATP 포스포리보실기 전이효소(HisG) 단백질, 및 이를 이용한 히스티딘의 생산 방법에 관한 것이다.
PCT/KR2018/008778 2017-08-02 2018-08-02 Atp 포스포리보실 전이효소 변이체 및 이를 이용한 l-히스티딘 생산방법 WO2019027267A2 (ko)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US16/635,359 US11098333B2 (en) 2017-08-02 2018-08-02 ATP phosphoribosyltransferase variant and method for producing L-histidine using the same
EP18841909.7A EP3647417A4 (en) 2017-08-02 2018-08-02 ATP-PHOSPHORIBOSYL TRANSFERASE MUTANTS AND L-HISTIDINE PRODUCTION PROCESS THEREFORE
CA3071280A CA3071280C (en) 2017-08-02 2018-08-02 Atp phosphoribosyltransferase variant and method for producing l-histidine using the same
JP2020503268A JP6789436B2 (ja) 2017-08-02 2018-08-02 Ａｔｐホスホリボシル転移酵素変異体及びそれを用いたｌ−ヒスチジンの生産方法
AU2018310134A AU2018310134B2 (en) 2017-08-02 2018-08-02 Atp phosphoribosyltransferase variant and method for producing l-histidine using the same
BR112020001762-0A BR112020001762B1 (pt) 2017-08-02 2018-08-02 Variante de atp fosforribosiltransferase, polinucleotídeo, vetor, microrganismo do gênero corynebacterium e método para produzir histidina com o uso do mesmo
CN201880049259.1A CN111315876B (zh) 2017-08-02 2018-08-02 Atp磷酸核糖基转移酶突变体以及使用该突变体生产l-组氨酸的方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0098205 2017-08-02
KR1020170098205A KR101904666B1 (ko) 2017-08-02 2017-08-02 Atp 포스포리보실기 전이효소 변이체 및 이를 이용한 l-히스티딘 생산방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/635,359 Continuation US11098333B2 (en) 2017-08-02 2018-08-02 ATP phosphoribosyltransferase variant and method for producing L-histidine using the same

Publications (2)

Publication Number Publication Date
WO2019027267A2 WO2019027267A2 (ko) 2019-02-07
WO2019027267A3 true WO2019027267A3 (ko) 2019-03-28

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Application Number Title Priority Date Filing Date
PCT/KR2018/008778 WO2019027267A2 (ko) 2017-08-02 2018-08-02 Atp 포스포리보실 전이효소 변이체 및 이를 이용한 l-히스티딘 생산방법

Country Status (11)

Country Link
US (1) US11098333B2 (ko)
EP (1) EP3647417A4 (ko)
JP (1) JP6789436B2 (ko)
KR (1) KR101904666B1 (ko)
CN (1) CN111315876B (ko)
AR (1) AR112922A1 (ko)
AU (1) AU2018310134B2 (ko)
CA (1) CA3071280C (ko)
TW (1) TWI694151B (ko)
UY (1) UY37828A (ko)
WO (1) WO2019027267A2 (ko)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
KR101904666B1 (ko) 2017-08-02 2018-11-29 씨제이제일제당 (주) Atp 포스포리보실기 전이효소 변이체 및 이를 이용한 l-히스티딘 생산방법
AU2019243241B2 (en) 2018-03-27 2022-12-01 Cj Cheiljedang Corporation A Novel Promoter And A Method For Producing L-Amino Acid Using The Same
KR102204917B1 (ko) * 2019-04-22 2021-01-20 씨제이제일제당 주식회사 L-히스티딘 생산능이 강화된 미생물 및 이를 이용한 히스티딘 생산방법
CN110184230A (zh) * 2019-05-30 2019-08-30 天津科技大学 一株高产l-组氨酸的基因工程菌及其构建方法与应用
KR20220092182A (ko) * 2020-12-24 2022-07-01 씨제이제일제당 (주) L-히스티딘 배출 단백질 및 이를 이용한 l-히스티딘 생산 방법
KR20220094261A (ko) * 2020-12-28 2022-07-06 대상 주식회사 히스티딘에 의한 피드백 억제가 감소된 atp-prt 변이체 및 이를 발현하는 히스티딘 생산 균주
KR20220094257A (ko) * 2020-12-28 2022-07-06 대상 주식회사 히스티딘에 의한 피드백 억제가 감소된 atp-prt 변이체 및 이를 발현하는 히스티딘 생산 균주
KR20220094260A (ko) * 2020-12-28 2022-07-06 대상 주식회사 히스티딘에 의한 피드백 억제가 감소된 atp-prt 변이체 및 이를 발현하는 히스티딘 생산 균주
KR20220094258A (ko) * 2020-12-28 2022-07-06 대상 주식회사 히스티딘에 의한 피드백 억제가 감소된 atp-prt 변이체 및 이를 발현하는 히스티딘 생산 균주
KR102433200B1 (ko) * 2020-12-28 2022-08-19 대상 주식회사 히스티딘에 의한 피드백 억제가 감소된 atp-prt 변이체 및 이를 발현하는 히스티딘 생산 균주
KR102281367B1 (ko) * 2021-01-26 2021-07-22 씨제이제일제당 (주) 신규한 5,10-메틸렌테트라하이드로폴레이트 리덕타제 변이체 및 이를 이용한 l-발린 생산 방법
KR102281360B1 (ko) * 2021-01-26 2021-07-22 씨제이제일제당 (주) 신규한 atp 포스포리보실트랜스퍼라제 변이체 및 이를 이용한 l-발린 생산 방법
KR102277034B1 (ko) * 2021-01-29 2021-07-13 씨제이제일제당 (주) 신규한 dahp 신타아제 변이체 및 이를 이용한 l-라이신 생산 방법
KR102344057B1 (ko) * 2021-01-29 2021-12-27 씨제이제일제당 (주) 신규한 단백질 변이체 및 이를 이용한 l-라이신 생산 방법
KR102306010B1 (ko) * 2021-04-07 2021-09-27 씨제이제일제당 (주) 신규한 분지쇄아미노산 투과효소 변이체 및 이를 이용한 l-발린 생산 방법
CN114829380B (zh) * 2021-04-12 2023-05-02 Cj第一制糖株式会社 新蛋白变体及使用其生产l-赖氨酸的方法
KR102277410B1 (ko) * 2021-04-29 2021-07-14 씨제이제일제당 주식회사 신규한 이중기능성 pyr 오페론 전사조절자/우라실 포스포리보실 전달 효소 변이체 및 이를 이용한 IMP 생산 방법
KR20230108789A (ko) 2022-01-11 2023-07-19 대상 주식회사 L-히스티딘 생산능이 향상된 에스케리치아 속 변이주 및 이를 이용한 l-히스티딘의 생산 방법
KR20230108790A (ko) 2022-01-11 2023-07-19 대상 주식회사 L-히스티딘 생산능이 향상된 에스케리치아 속 변이주 및 이를 이용한 l-히스티딘의 생산 방법
KR102421920B1 (ko) * 2022-02-16 2022-07-21 대상 주식회사 Atp 신타아제 신규 변이체 및 이를 이용한 l-방향족 아미노산 생산 방법
CN116254242B (zh) * 2022-12-21 2024-01-30 江南大学 一种atp磷酸核苷转移酶突变体及产l-组氨酸的谷氨酸棒杆菌

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Also Published As

Publication number Publication date
CN111315876B (zh) 2021-10-26
JP6789436B2 (ja) 2020-11-25
EP3647417A2 (en) 2020-05-06
EP3647417A4 (en) 2021-04-14
CN111315876A (zh) 2020-06-19
BR112020001762A2 (pt) 2020-07-21
US11098333B2 (en) 2021-08-24
AU2018310134A1 (en) 2020-02-06
KR101904666B1 (ko) 2018-11-29
AU2018310134B2 (en) 2022-04-07
AR112922A1 (es) 2020-01-08
WO2019027267A2 (ko) 2019-02-07
US20210010042A1 (en) 2021-01-14
CA3071280A1 (en) 2019-02-07
JP2020530771A (ja) 2020-10-29
UY37828A (es) 2018-09-28
TWI694151B (zh) 2020-05-21
TW201910512A (zh) 2019-03-16
CA3071280C (en) 2022-05-31

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