WO2019021801A1 - Préparation externe pour la peau et procédé pour la produire - Google Patents

Préparation externe pour la peau et procédé pour la produire Download PDF

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WO2019021801A1
WO2019021801A1 PCT/JP2018/025929 JP2018025929W WO2019021801A1 WO 2019021801 A1 WO2019021801 A1 WO 2019021801A1 JP 2018025929 W JP2018025929 W JP 2018025929W WO 2019021801 A1 WO2019021801 A1 WO 2019021801A1
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Prior art keywords
mass
vaseline
stirring
external preparation
skin
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PCT/JP2018/025929
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English (en)
Japanese (ja)
Inventor
就人 松田
田嶋　和夫
今井　洋子
佳那 宮坂
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学校法人神奈川大学
就人 松田
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Priority to JP2019532486A priority Critical patent/JP6958878B2/ja
Publication of WO2019021801A1 publication Critical patent/WO2019021801A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a skin external preparation and a method for producing the same.
  • Vaseline is widely used as a base for external preparations for skin because of its excellent safety, skin protection action and moisturizing action.
  • the petrolatum has a sticky property
  • the formulation containing petrolatum has a bad feeling in use.
  • Patent Document 1 reports an external preparation which contains petrolatum at a high concentration and adjusts the melting point and stringiness value to specific values. By adjusting the melting point and the stringiness value in this manner, it is possible to suppress the stickiness of the external preparation due to vaseline.
  • petrolatum is not emulsified and is merely diluted with a liquid oil solution. Since the oily substance containing vaseline comes in direct contact with the skin by the application, the sticky feeling can not be suppressed, and the feeling of use is not necessarily sufficient.
  • the present invention has been made in view of the above-mentioned circumstances, and an object thereof is to provide a skin external preparation which is excellent in feeling of use while containing vaseline.
  • the present inventors diligently studied to solve the above problems. As a result, it was found that by emulsifying petrolatum using specific polycondensation polymer particles or closed vesicles, it is possible to provide an external preparation for skin that contains petrolatum and has an excellent feeling in use, and completed the present invention. Specifically, the present invention provides the following.
  • a liquid or semi-solid oil phase comprising a vaseline or containing vaseline and having a viscosity of 5000 mPa ⁇ s or more at 25 ° C., a water phase, a polycondensation polymer particle having a hydroxyl group and / or a closed vesicle
  • FIG. 6 is an optical micrograph of a sample obtained in Example 2.
  • FIG. 6 is an optical micrograph of a sample obtained in Example 3. It is a photograph figure after leaving still for 24 hours the sample obtained in Examples 11-15.
  • FIG. 16 is an optical micrograph of a sample obtained in Example 7.
  • FIG. 7 is an optical micrograph of a sample obtained in Comparative Example 1;
  • the skin external preparation according to the present invention is a liquid or semi-solid oil phase comprising a vaseline or containing vaseline and having a viscosity of 5000 mPa ⁇ s or more at 25 ° C., an aqueous phase, and a polycondensation polymer particle having a hydroxyl group And / or a closed endoplasmic reticulum formed by an amphiphilic substance that forms a closed endoplasmic reticulum.
  • this skin external preparation consists of the polycondensation polymer particle and / or the said closed vesicle from the O / W type emulsion which intervenes in the interface of an oil phase and a water phase.
  • ⁇ Polycondensed polymer particles, closed vesicles The polycondensed polymer particles and the closed vesicles intervene at the interface of the aqueous phase and the oil phase containing vaseline, and form an emulsified state via van der Waals force, so that the composition and conditions of the aqueous phase and the oil phase are different. It is possible to constitute a good emulsified state.
  • the inventors of the present invention have been able to emulsify highly viscous petrolatum at an ordinary temperature extremely stably by such an emulsification method, and the oil phase containing petrolatum is a polycondensation polymer particle or a closed vesicle physically.
  • the viscosity of the external preparation for skin can be kept low by having the emulsion structure coated on Such external preparations for skin are sticky on the skin because an aqueous phase is present between the oil phase and the skin when the external force is applied by application or the like and the vaseline contained in the oil phase is drawn on the skin. Feeling can be suppressed.
  • the external preparation for skin has good elongation and can be applied widely and uniformly.
  • the external preparation for skin of the present invention has a sufficiently high coating feeling (water retention) even when applied thinly on the skin. In particular, the water retention of the skin is significantly higher than that of conventional commercial vaseline preparations.
  • the emulsified state of the oil solution containing the stabilized petrolatum of the present invention is achieved by emulsifying using polycondensation polymer particles or closed vesicles.
  • a highly viscous oil such as petrolatum can not be emulsified with conventional surfactants and the like.
  • the emulsified structure of the oil solution containing petrolatum stabilized in this way is not destroyed by diluting the skin external preparation with water. Therefore, the skin external preparation of the present invention can be easily diluted with water, and the concentration and viscosity can be appropriately adjusted.
  • the vaseline-containing external skin preparation obtained by the method as described in Patent Document 1 it can not be diluted with water.
  • the polycondensation polymer having a hydroxyl group may be either a natural polymer or a synthetic polymer, and may be appropriately selected according to the use of the emulsifier.
  • natural polymers are preferable in terms of excellent safety and generally inexpensive, and sugar polymers described below are more preferable in terms of excellent emulsifying function.
  • the term "particles" includes both single particles of polycondensation polymers or those in which single particles are connected with one another, but does not include aggregates (having a network structure) prior to single particles.
  • the sugar polymer is a polymer having a glucoside structure such as cellulose and starch.
  • a glucoside structure such as cellulose and starch.
  • monosaccharides such as ribose, xylose, rhamnose, fucose, glucose, mannose, glucuronic acid and gluconic acid
  • those produced by microorganisms with several sugars as constituents xanthan gum, gum arabic, guar gum, karaya gum, carrageenan , Pectin, fucoidan, quinseed gum, tolanto gum, locust bean gum, galactomannan, curdlan, gellan gum, fucogel, casein, gelatin, starch, collagen, hyaluronic acid, hyaluronic acid derivatives, natural polymers such as polymycetes polysaccharide, methylcellulose Ethylcellulose, Methylhydroxypropylcellulose, Carboxymethylcellulose, Hydroxymethylcellulose, Hydroxyprop
  • amphiphilic substances that form closed vesicles include, but are not limited to, derivatives of polyoxyethylene hydrogenated castor oil represented by the following general formula 1.
  • E which is the average added mole number of ethylene oxide, is 3 to 100.
  • amphiphilic substance a phospholipid, a phospholipid derivative or the like, in particular, one in which a hydrophobic group and a hydrophilic group are ester-bonded may be employed.
  • DLPC having a carbon chain length of 12 (1,2-Dilauroyl-sn-glycero-3-phospho-rac-1-choline) and a carbon chain length of 14 among the structures represented by the following general formula 2 DMPC (1,2-Dimyristoyl-sn-glycero-3-phospho-rac-1-choline), carbon chain length 16 DPPC (1,2-Dipalmitolyl-sn-glycero-3-phospho-rac-1-choline) Can be adopted.
  • Na salt or NH4 salt of DLPG (1,2-Dilauroyl-sn-glycero-3-phospho-rac-1-glycerol) having a carbon chain length of 12 among carbon atoms having a carbon chain length 12 among the structures represented by the following general formula 3;
  • Na salt or NH4 salt of 14-long DMPG (1,2-Dimyristoyl-sn-glycero-3-phospho-rac-1-glycerol), DPPG with a carbon chain length of 16 (1,2-Dipalmitolyl-sn-glycero-3
  • the Na salt or NH 4 salt of (phospho-rac-1-glycerol) may be employed.
  • lecithin such as egg yolk lecithin or soya lecithin may be employed as the phospholipid.
  • the total amount of the polycondensation polymer particles and the closed vesicles is not particularly limited, but is preferably 0.001% by mass or more, and more preferably 0.002% by mass or more based on the total amount of the O / W emulsion.
  • the content is more preferably 0.005% by mass or more, and particularly preferably 0.01% by mass or more.
  • the total amount of the polycondensation polymer particles and the closed vesicles is 50% by mass or less, 40% by mass or less, 30% by mass or less, 25% by mass or less, and 20% by mass or less based on the total amount of the O / W emulsion. , 15% by mass or less, and 10% by mass or less.
  • the average particle size of the polymerizable polymer particles and the closed vesicles is about 8 nm to 800 nm before forming the emulsion, but is about 8 nm to 500 nm in the O / W type emulsion structure.
  • the polycondensation polymer particles and the closed vesicles may contain only one or both. If both are included, e.g. separately emulsified emulsions may be mixed.
  • the “average particle diameter” is a value obtained by measurement by a dynamic light scattering method using a particle size distribution measuring apparatus FPAR (manufactured by Otsuka Electronics Co., Ltd.) and determined by Contin analysis.
  • Vaseline mainly constitutes the oil phase of the O / W emulsion structure.
  • vaseline used in the external preparation for skin of the present invention examples include Sun White P-150, Sun White P-200, Sun White S-200 (all manufactured by Nikko Guatemala Co., Ltd.), Nom Coat W (manufactured by Nisshin Oillio Co., Ltd.) CROLATUM V (manufactured by Croda Japan), Peren Snow, Ultima White, Vaseline Base No. Commercially available 4 (above, made by Penreco), PROTOPET Super White, SONNONE ONE DM, SONNONE CM, MINERAL GELLY # 10, MINERAL GELLY # 14, MINERAL GELLY # 17, SONOJELL # 4, SONOJELL # 9 (made by Sonneborn), etc. It is also possible to use it in combination as appropriate.
  • the total amount of petrolatum may be 1% by mass to 80% by mass with respect to the skin external preparation.
  • the content is preferably 2% by mass or more, more preferably 3% by mass or more, still more preferably 5% by mass or more, and 7% by mass or more. Being particularly preferred.
  • the total amount of vaseline is equal to or more than the required amount, a coating feeling after application can be sufficiently obtained, while the external preparation for skin according to one embodiment of the present invention contains this amount of vaseline Low viscosity, excellent in feeling of use.
  • the total amount of vaseline is preferably 70% by mass or less, more preferably 60% by mass or less, and still more preferably less than 50% by mass, in view of suppressing stickiness.
  • the content is at most mass%.
  • the total amount of the oil phase containing petrolatum may be in an amount of 1% by mass to 80% by mass with respect to the external preparation for skin. Moreover, 2 mass% or more, 3 mass% or more, 5 mass% or more, and 7 mass% or more may be sufficient. On the other hand, the total amount of vaseline may be 70% by mass or less, 60% by mass or less, less than 50% by mass, and 40% by mass or less with respect to the skin external preparation.
  • oil phase may contain the arbitrary components mentioned later other than a vaseline.
  • the water phase is a medium for dispersing petrolatum as an oil phase in the O / W emulsion structure.
  • the content of the aqueous phase is not particularly limited, but may be 20% by mass to 99.99% by mass, preferably 25% by mass to 98.5% by mass, with respect to the external preparation for skin, preferably 30% by mass. More preferably, it is in an amount of% to 98% by mass.
  • the water phase may contain the arbitrary components mentioned later other than water.
  • the external preparation for skin of the present invention can contain optional components other than the above-mentioned essential components for the purpose of enhancing or reinforcing the effects of the present invention, and other effects.
  • optional components polyhydric alcohols and / or glycol ethers, surfactants, liquid oils, cell activation components, antibacterial components, anti-inflammatory components, anti-inflammatory analgesic components, antipruritic components, vitamins, local anesthetic components , Moisturizing component, whitening component, antioxidant component, antiaging component, keratin soft component, blood circulation promoting component, component having preventive and / or repairing action of DNA damage, ultraviolet light absorbing component, ultraviolet light scattering component, astringent component, hair growth component Antihistamine component, antiseptic component, other additives and the like.
  • the optional components as described above are distributed into the water phase or the oil phase depending on their degree of hydrophilicity and lipophilicity.
  • the content of the components contained in the oil phase other than vaseline is not particularly limited, but is preferably 50% by mass or less, more preferably 30% by mass or less, and 20% by mass or less with respect to the skin external preparation. It is further preferred that The content of the components contained in the aqueous phase other than water is not particularly limited, but is preferably 50% by mass or less, more preferably 30% by mass or less, and more preferably 20% by mass with respect to the external preparation for skin. It is more preferable that it is the following.
  • the viscosity of the external preparation for skin of the present invention is preferably 400000 mPa ⁇ s or less, more preferably 200000 mPa ⁇ s or less, still more preferably 5000 mPa ⁇ s or less, and 3000 mPa ⁇ s or less preferable.
  • the viscosity may be, for example, 10 mPa ⁇ s or more, 20 mPa ⁇ s or more, 50 mPa ⁇ s or more, and may be 100 mPa ⁇ s or more, 200 mPa ⁇ s or more.
  • “viscosity” refers to a value measured under the conditions of 25 ° C.
  • the skin external preparation of the present invention can easily form an emulsified state by stirring or the like, and can have an O / W type emulsion structure in the emulsified state to stably maintain the emulsified state.
  • the skin external preparation of the present invention may take various forms such as liquid, emulsion, cream, solid, gel and the like.
  • an O / W emulsion-type external skin preparation containing vaseline stably emulsified without using a thickener or an emulsification aid As described above, it is possible to obtain an O / W emulsion-type external skin preparation containing vaseline stably emulsified without using a thickener or an emulsification aid. Also, such an external preparation for skin of the present invention has an O / W emulsion type structure, and the sticky feeling peculiar to vaseline, which has been a conventional problem, is remarkably suppressed, and the sense of discomfort or failure to the skin is not good. It can be applied without pleasure.
  • the skin external preparation according to the present invention is prepared by heating the dispersed vesicle of a closed vesicle formed by an amphiphilic substance forming a closed vesicle and / or a single particle of a polycondensation polymer having a hydroxyl group to a temperature above the melting point. It can be produced by melting melted petrolatum or by stirring and mixing an oil containing petrolatum dropwise.
  • a method of producing dispersed water of closed vesicles and / or single particles of polycondensation polymer having hydroxyl groups formed by amphiphiles forming closed vesicles is omitted because it is conventionally known, for example, in Japanese Patent No. 3855203. .
  • the compounding quantity and each option component of each component it is as having mentioned above.
  • Dispersion stability test Example 1 5 g of white vaseline heated at 90 ° C. was added dropwise while heating and stirring the dispersion prepared by adding 20 g of ion exchanged water to 25 g of a 0.5% by mass dispersion of stearoxyhydroxypropyl methylcellulose at 90 ° C. (after mixing 10% by weight of white petrolatum, 0.25% by weight of stearoxyhydroxypropylmethylcellulose, based on the total amount of liquid). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. It was 450 mPa * s when the viscosity of this emulsion was measured.
  • Example 2 10 g of ion-exchanged water was added to 25 g of a 0.5% by mass dispersion of stearoxyhydroxypropyl methylcellulose, and 15 g of white vaseline heated at 90 ° C. was added dropwise while heating and stirring the dispersion at 90 ° C. 30% by weight of white petrolatum, 0.25% by weight of stearoxyhydroxypropylmethylcellulose, based on the total amount of liquid). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. It was 800 mPa * s when the viscosity of this emulsion was measured.
  • Example 3 25 g of white petrolatum heated at 90 ° C. was added dropwise while heating and stirring at 25 ° C. with 25 g of a 0.5 wt% dispersion of stearoxyhydroxypropyl methylcellulose (50 wt% of white petrolatum based on the total amount of liquids after mixing, Stearoxy hydroxypropyl methylcellulose 0.25% by mass). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. It was 2450 mPa * s when the viscosity of this emulsion was measured.
  • Example 4 12 g of white vaseline heated at 90 ° C. was added dropwise while heating and stirring the dispersion prepared by adding 48 g of ion exchanged water to 60 g of a 0.5% by mass dispersion of stearoxyhydroxypropyl methylcellulose at 90 ° C. (after mixing 10% by weight of white petrolatum, 0.25% by weight of stearoxyhydroxypropylmethylcellulose, based on the total amount of liquid). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. In addition, the ratio of each component is the same as that of Example 1. Thereafter, using a Starburst Mini manufactured by Sugino Machine Co., Ltd., high pressure emulsification was performed for 1 to 3 passes under conditions of a temperature of 25 ° C. and a pressure of 150 MPa.
  • Example 5 5 g of white vaseline heated at 90 ° C. was added dropwise while heating and stirring the dispersion prepared by adding 35 g of ion exchanged water to 10 g of a 0.5% by mass dispersion of stearoxyhydroxypropyl methylcellulose at 90 ° C. (after mixing 10% by weight of white petrolatum, 0.10% by weight of stearoxyhydroxypropyl methylcellulose) based on the total amount of liquid). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion.
  • Example 6 15 g of white vaseline heated at 90 ° C. was added dropwise while heating and stirring the dispersion prepared by adding 25 g of ion exchanged water to 10 g of a 0.5% by mass dispersion of stearoxyhydroxypropyl methylcellulose at 90 ° C. (after mixing 30% by weight of white petrolatum, 0.10% by weight of stearoxyhydroxypropyl methylcellulose) based on the total amount of liquid). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion.
  • Example 7 25 g of white vaseline heated at 90 ° C. was added dropwise while heating and stirring the dispersion prepared by adding 15 g of ion exchanged water to 10 g of a 0.5% by mass dispersion of stearoxyhydroxypropyl methylcellulose at 90 ° C. (after mixing 50% by weight of white petrolatum, 0.10% by weight of stearoxyhydroxypropyl methylcellulose) based on the total amount of liquid). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion.
  • Example 8 5 g of white vaseline heated at 90 ° C. was added dropwise while heating and stirring the dispersion prepared by adding 40 g of ion exchanged water to 5 g of a 0.5% by mass dispersion of stearoxyhydroxypropyl methylcellulose at 90 ° C. (after mixing 10% by weight of white petrolatum, 0.05% by weight of stearoxyhydroxypropylmethylcellulose, based on the total amount of liquid). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion.
  • Example 9 30 g of ion-exchanged water was added to 5 g of a 0.5% by mass dispersion of stearoxyhydroxypropyl methylcellulose, and 15 g of white vaseline heated at 90 ° C. was added dropwise while heating and stirring the dispersion at 90 ° C. 30% by weight of white petrolatum, 0.05% by weight of stearoxyhydroxypropyl methylcellulose, based on the total amount of liquid). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion.
  • Example 10 25 g of white vaseline heated at 90 ° C. was added dropwise while heating and stirring the dispersion prepared by adding 20 g of ion exchanged water to 5 g of a 0.5% by mass dispersion of stearoxyhydroxypropyl methylcellulose at 90 ° C. (after mixing 50% by weight of white petrolatum, 0.05% by weight of stearoxyhydroxypropylmethylcellulose, based on the total amount of liquid). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion.
  • Example 11 10g of white vaseline heated at 90 ° C is added dropwise while heating and stirring a dispersion prepared by adding 40g of ion exchanged water to 50g of a 6% by mass dispersion of polyoxyethylene curing effect castor oil (HCO-10) at 90 ° C. (10% by mass of white petrolatum, 3% by mass of polyoxyethylene curing effect castor oil, based on the total amount of liquids after mixing). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. It was 10.2 mPa * s when the viscosity of this emulsion was measured.
  • HCO-10 polyoxyethylene curing effect castor oil
  • Example 12 30g of ion-exchanged water was added to 50g of a 6% by mass dispersion of polyoxyethylene curing effect castor oil (HCO-10), and while heating and stirring at 90 ° C, 20g of white vaseline heated at 90 ° C was dropped (20% by mass of white petrolatum, 3% by mass of polyoxyethylene curing effect castor oil, based on the total amount of liquids after mixing). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. It was 31.2 mPa * s when the viscosity of this emulsion was measured.
  • HCO-10 polyoxyethylene curing effect castor oil
  • Example 13 30g of white vaseline heated at 90 ° C is added dropwise while heating and stirring a dispersion prepared by adding 20g of ion exchanged water to 50g of a 6% by mass dispersion of polyoxyethylene curing effect castor oil (HCO-10) at 90 ° C. (30% by mass of white petrolatum, 3% by mass of polyoxyethylene curing effect castor oil, based on the total amount of liquids after mixing). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. When the viscosity of this emulsion was measured, it was 93.78 mPa ⁇ s.
  • HCO-10 polyoxyethylene curing effect castor oil
  • Example 14 40 g of white vaseline heated at 90 ° C. while heating and stirring at 90 ° C. while heating and stirring a dispersion prepared by adding 10 g of ion exchanged water to 50 g of a 6 mass% dispersion of polyoxyethylene curing effect castor oil (HCO-10) (40% by weight of white petrolatum, 3% by weight of polyoxyethylene curing effect castor oil, based on the total amount of liquids after mixing). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. The viscosity of this emulsion was measured to be 104.65 mPa ⁇ s.
  • HCO-10 polyoxyethylene curing effect castor oil
  • Example 15 50 g of white vaseline heated at 90 ° C. was dropped while heating and stirring 50 g of a 6% by mass dispersion of polyoxyethylene curing effect castor oil (HCO-10) at 90 ° C. (white relative to the total amount of liquids after mixing 50% by weight of vaseline, 3% by weight of polyoxyethylene curing effect castor oil). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. The viscosity of this emulsion was measured to be 377.15 mPa ⁇ s.
  • HCO-10 polyoxyethylene curing effect castor oil
  • Example 16 10 g of white vaseline heated at 90 ° C. while heating and stirring at 90 ° C. while heating and stirring a dispersion prepared by adding 70 g of ion exchanged water to 20 g of a 30 mass% dispersion of polyoxyethylene curing effect castor oil (HCO-80) (10% by weight of white petrolatum, 6% by weight of polyoxyethylene curing effect castor oil, based on the total amount of the emulsion). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. When the viscosity of this emulsion was measured, it was 30.25 mPa ⁇ s.
  • HCO-80 polyoxyethylene curing effect castor oil
  • Example 17 20 g of a 30% by mass dispersion of a polyoxyethylene curing effect castor oil (HCO-80) 60 g of ion-exchanged water was prepared by adding 60 g of white vaseline heated at 90 ° C. while heating and stirring the dispersion at 90 ° C. (20% by weight of white petrolatum, 6% by weight of polyoxyethylene curing effect castor oil, based on the total amount of the emulsion). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. It was 35.475 mPa * s when the viscosity of this emulsion was measured.
  • HCO-80 polyoxyethylene curing effect castor oil
  • Example 18 30 g of 30% by mass dispersion of polyoxythylene curing effect castor oil (HCO-80) 50 g of white vaseline heated at 90 ° C. is added dropwise while heating and stirring the dispersion prepared by adding 50 g of ion exchanged water at 90 ° C. (30% by weight of white petrolatum, 6% by weight of polyoxyethylene curing effect castor oil, based on the total amount of the emulsion). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. When the viscosity of this emulsion was measured, it was 48.675 mPa ⁇ s.
  • Example 19 40 g of white vaseline heated at 90 ° C while heating and stirring a dispersion prepared by adding 40 g of ion exchanged water to 20 g of a 30% by mass dispersion of polyoxyethylene curing effect castor oil (HCO-80) (40% by weight of white petrolatum, 6% by weight of polyoxyethylene curing effect castor oil, based on the total amount of the emulsion). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. The viscosity of this emulsion was measured to be 103.95 mPa ⁇ s.
  • HCO-80 polyoxyethylene curing effect castor oil
  • Example 20 30 g of 30 wt% dispersion of polyoxyethylene curing effect castor oil (HCO-80) 30 g of ion-exchanged water is prepared by adding 30 g of white vaseline heated at 90 ° C. while heating and stirring at 90 ° C. (50% by weight of white petrolatum, 6% by weight of polyoxyethylene curing effect castor oil, based on the total amount of the emulsion). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. When the viscosity of this emulsion was measured, it was 459.25 mPa ⁇ s.
  • HCO-80 polyoxyethylene curing effect castor oil
  • Example 21 60 g of white vaseline heated at 90 ° C while heating and stirring a dispersion prepared by adding 20 g of ion exchanged water to 20 g of a 30% by mass dispersion of polyoxyethylene curing effect castor oil (HCO-80) and heating at 90 ° C (60% by weight of white petrolatum, 6% by weight of polyoxyethylene curing effect castor oil, based on the total amount of the emulsion). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. It was 43752 mPa * s when the viscosity of this emulsion was measured.
  • HCO-80 polyoxyethylene curing effect castor oil
  • Example 22 70 g of white vaseline heated at 90 ° C is added dropwise while heating and stirring the dispersion prepared by adding 10 g of ion exchanged water to 20 g of a 30% by mass dispersion of polyoxyethylene curing effect castor oil (HCO-80) at 90 ° C. (70% by weight of white petrolatum, 6% by weight of polyoxyethylene curing effect castor oil, based on the total amount of the emulsion). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. The viscosity of this emulsion was measured to be 358,870 mPa ⁇ s.
  • HCO-80 polyoxyethylene curing effect castor oil
  • Example 23 While heating and stirring 20 g of a 30% by mass dispersion of polyoxyethylene curing effect castor oil (HCO-80) at 90 ° C., 80 g of white vaseline heated at 90 ° C. was dropped (with respect to the total amount of emulsion, white petrolatum 80 % By mass, polyoxyethylene curing effect castor oil 6% by mass). After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion. This liquid had a high viscosity, and the viscosity could not be measured by a B-type viscometer.
  • HCO-80 polyoxyethylene curing effect castor oil
  • FIG. 1 is a photograph of the samples obtained in Examples 1 to 3 after being allowed to stand for 24 hours.
  • the emulsions of petrolatum obtained in Examples 1 to 3 remained stable.
  • FIG. 2 (a) is an optical micrograph of the sample before high-pressure emulsification treatment in Example 4, and FIGS. 2 (b), (c) and (d) are respectively 1 pass, 2 passes and 3 passes. It is an optical microscope picture after leaving the sample after high-pressure emulsification processing to stand for 24 hours. From FIG. 2 (a), emulsified particles were also confirmed in the sample before the high pressure emulsification treatment. After that, it was found that the emulsified particles can be easily micronized by high-pressure emulsification treatment.
  • FIG. 3 is an optical micrograph of the sample obtained in Example 2.
  • FIG. 4 is an optical micrograph of the sample obtained in Example 3. Emulsified particles were confirmed from FIGS. 3 and 4.
  • FIG. 5 is a photograph of the samples obtained in Examples 11 to 15 after being allowed to stand for 24 hours.
  • the emulsion of petrolatum obtained in Examples 11 to 15 also maintained a stable state.
  • FIG. 6 is a photograph of the samples obtained in Examples 16-23 after being allowed to stand for 24 hours.
  • the emulsion of petrolatum obtained in Examples 16 to 23 also maintained a stable state.
  • petrolatum is stably emulsified to form an O / W emulsion structure, regardless of whether the polycondensation polymer particles or the closed vesicles are used as an emulsifier.
  • a cream containing petrolatum was produced according to Formulation Example 4 of Patent Document 1. Specifically, 40.0% by mass of white petrolatum (Cloratum V), 10.0% by mass of white petrolatum (MINERAL JELLY # 10), 3.0% by mass of shea butter, 2.0% by mass of diglycerin, dipropylene glycol 3 .0% by mass, 1.0% by mass of hydroxyethyl urea, 0.5% by mass of carboxyvinyl polymer, 0.1% by mass of xanthan gum, 0.02% by mass of sodium hyaluronate, 3.5% by mass of glyceryl stearate, Ethylene hydrogenated castor oil 2.5% by mass, behenyl alcohol 2.0% by mass, stearyl alcohol 2.0% by mass, hydrolyzed soy protein 0.2% by mass, Tambrissa Trichophila leaf extract 0.1% by mass, ion exchanged water 30.38 mass% was mixed and e
  • FIG.7 (a) (b) is a photograph figure immediately after dripping the sample obtained in Example 7 in the water of 80 degreeC
  • FIG.7 (c) shows the sample obtained in Example 7 80. It is a photograph figure 5 minutes after dripping in water of ° C. 8 (a) and 8 (b) are photographs immediately after dropping the sample obtained in Comparative Example 1 into water at 80 ° C.
  • FIG. 8 (c) is a sample obtained in Comparative Example 1 Is dropped into water at 80.degree. C., and a photograph after 5 minutes.
  • Example 7 was easily dispersed in water, and it was found that a stable O / W emulsion was formed even after dilution. On the other hand, it was found from FIG. 8 that the sample obtained in Comparative Example 1 was not dispersed in water, and oil droplets separated after 5 minutes.
  • FIG. 9 is an optical micrograph of a sample obtained in Example 7.
  • FIG. 10 is an optical micrograph of the sample obtained in Comparative Example 1. From FIG. 9, it was found that the O / W type emulsion was not formed in Comparative Example 1 while the O / W type emulsion was formed in Example 7.
  • Example 24 The samples obtained in Example 24 and Japanese Pharmacopoeia white petrolatum were subjected to sensory evaluation by 15 panelists (12 women and 3 men) in their 20s and 40s. Specifically, the sample obtained in Example 24 was applied to the instep of the right hand, the right forearm, and the right half face, and white vaseline of Japanese Pharmacopoeia was applied to the instep, left forearm and left half face of the left hand.
  • Example 25 10 mass% petrolatum sample A dispersion prepared by adding 40 g of ion exchanged water to 50 g of a 0.5 mass% dispersion of stearoxyhydroxypropyl methylcellulose was heated to 90 ° C. while heating and stirring at 90 ° C. 10 g of white vaseline was dropped. After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion.
  • Example 26 20 mass% petrolatum sample A dispersion prepared by adding 30 g of ion exchanged water to 50 g of a 0.5 mass% dispersion of stearoxyhydroxypropylmethylcellulose was heated to 90 ° C. while heating and stirring at 90 ° C. 20 g of white vaseline was dropped. After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion.
  • Example 27 30% by mass vaseline sample A dispersion prepared by adding 20 g of ion exchanged water to 50 g of a 0.5% by mass dispersion of stearoxyhydroxypropylmethylcellulose was heated to 90 ° C while heating and stirring at 90 ° C. 30 g of white vaseline was dropped. After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion.
  • Example 28 40 mass% petrolatum sample A dispersion prepared by adding 10 g of ion-exchanged water to 50 g of a 0.5 mass% dispersion of stearoxyhydroxypropylmethylcellulose was heated to 90 ° C. while heating and stirring at 90 ° C. 40 g of white vaseline was dropped. After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion.
  • Example 29 50% by mass of vaseline sample 50 g of a 0.5% by mass dispersion of stearoxyhydroxypropylmethylcellulose was added dropwise while heating and stirring at 90 ° C, and 50 g of white vaseline heated to 90 ° C was dropped. After dripping all, heating was maintained for 5 minutes while stirring. Then, it cooled, stirring. The resulting liquid was a white emulsion.
  • Example 25 With respect to the samples obtained in Examples 25 to 29 and the Japanese Pharmacopoeia white petrolatum, evaluations were made of the amount of keratinous water and the amount of transdermal water evaporation of the skin according to use. Specifically, the test subject is a male in their 40s, and the test period is 2 weeks in December 2017 in Example 26, and 2 weeks in February to April in 2018 in Examples 25 and 27-29. Example 25 was for 4 weeks only).
  • MultiProbe Adapter MPA 6 (made by Courage + Khazaka, Germany) is used as a measuring instrument, Corneometer CM 825 as a measurement probe for measuring stratum corneum water, Tewameter TM300 as a measurement probe for measuring transcutaneous water loss, and temperature is 20 degrees. It measured on the conditions of 50% of humidity.
  • the Japanese Pharmacopoeia white vaseline is in the left half inner half of the left hand and the inner half of the left cheek, and the samples obtained in Examples 25 to 29 in the right inner half of the right hand half and the inner half of the right cheek are 7 am and 2 pm Vaseline was applied for 2 weeks (4 weeks for Example 25 only) three times a day at 8:00 pm for the amount of 2 FTU (twice the amount on the first joint of the index finger (1 FTU)) at each of the left and right sites .
  • 2 FTU tilt the amount on the first joint of the index finger
  • Tables 7 to 11 show the measurement results of the stratum corneum water content.
  • the stratum corneum water content in the forehead, T zone, scalp, cheeks, buttocks, temples, mouth, upper body, back and neck is less than 50 and "very dry", 50 to 60 or less “Dry”, rated above 60 for "sufficient moisture”.
  • Tables 12 to 16 show the results of measurement of transdermal water loss.
  • the transcutaneous water loss in Tables 12-16 is 0-10, "very good”, 10-15, “good”, 15-25, “normal”, 25-30, “somewhat bad” , “More than 30” is rated “very bad”.
  • the amount of transdermal water loss was significantly reduced in any part of the back of the hand and the cheek as compared to before the test.
  • the Japanese Pharmacopoeia white vaseline did not show such a significant reduction effect. Therefore, it can be seen that, by emulsifying with the polycondensation polymer particles and the closed endoplasmic reticulum, the vaseline has a high keratin barrier function improving effect and a skin quality improving effect.

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Abstract

La présente invention concerne une préparation externe pour la peau, qui présente une excellente sensation lors de l'utilisation malgré qu'elle contienne de la vaseline. La préparation externe pour la peau selon la présente invention contient une phase huileuse liquide ou semi-solide qui est composée de vaseline ou contient de la vaseline et a une viscosité de 5000 mPa ou plus à 25 °C, une phase aqueuse, et des vésicules fermées formées à partir de particules de polymère de polycondensation comprenant chacun un groupe hydroxyle et/ou une substance amphipathique capable de former une vésicule fermée, et a une structure d'émulsion de type O/E telle que les particules de polymère de polycondensation et/ou les vésicules fermées sont situées à l'interface entre la phase huileuse et la phase aqueuse. De préférence, la teneur de la phase huileuse est de 70 % en masse ou moins par rapport à la quantité totale de la préparation externe pour la peau. Il est préférable que la teneur en vaseline soit comprise entre 2 et 70 % en masse inclus par rapport à la quantité totale de la préparation externe pour la peau. Il est également préférable que la viscosité à 25 °C soit inférieure ou égale à 400000 mPa.s.
PCT/JP2018/025929 2017-07-28 2018-07-09 Préparation externe pour la peau et procédé pour la produire WO2019021801A1 (fr)

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WO2023181526A1 (fr) 2022-03-24 2023-09-28 大王製紙株式会社 Produit cosmétique à base d'huile

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WO2023181526A1 (fr) 2022-03-24 2023-09-28 大王製紙株式会社 Produit cosmétique à base d'huile

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