WO2019015814A1 - Utilisation de protéine-1 de type chitinase-3 (chi3l1) en tant qu'auto-antigène dans des troubles auto-immuns du système digestif - Google Patents

Utilisation de protéine-1 de type chitinase-3 (chi3l1) en tant qu'auto-antigène dans des troubles auto-immuns du système digestif Download PDF

Info

Publication number
WO2019015814A1
WO2019015814A1 PCT/EP2018/058219 EP2018058219W WO2019015814A1 WO 2019015814 A1 WO2019015814 A1 WO 2019015814A1 EP 2018058219 W EP2018058219 W EP 2018058219W WO 2019015814 A1 WO2019015814 A1 WO 2019015814A1
Authority
WO
WIPO (PCT)
Prior art keywords
chi3l1
disease
protein
autoantibodies
sample
Prior art date
Application number
PCT/EP2018/058219
Other languages
English (en)
Inventor
Dirk Roggenbuck
Peter SCHIERACK
Claudia DEUTSCHMANN
Original Assignee
Ga Generic Assays Gmbh
Brandenburgische Technische Universität Cottbus-Senftenberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ga Generic Assays Gmbh, Brandenburgische Technische Universität Cottbus-Senftenberg filed Critical Ga Generic Assays Gmbh
Publication of WO2019015814A1 publication Critical patent/WO2019015814A1/fr

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • G01N2800/065Bowel diseases, e.g. Crohn, ulcerative colitis, IBS

Abstract

L'invention concerne un procédé in vitro de diagnostic, de pronostic, d'évaluation de risque, de surveillance, de guidage thérapeutique et/ou de contrôle thérapeutique d'un trouble auto-immun du système digestif, tel qu'une maladie intestinale inflammatoire et une maladie hépatique auto-immune, dans lequel des auto-anticorps qui se lient à la protéine-1 de type chitinase-3 (CHI3L1) sont détectés en tant que marqueur d'une telle maladie. L'invention concerne donc l'utilisation de CHI3L1 en tant qu'auto-antigène dans des diagnostics auto-immuns dans des maladies du système digestif. L'invention concerne un kit et un système pour permettre de mettre en œuvre le procédé.
PCT/EP2018/058219 2017-07-20 2018-03-29 Utilisation de protéine-1 de type chitinase-3 (chi3l1) en tant qu'auto-antigène dans des troubles auto-immuns du système digestif WO2019015814A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17182422 2017-07-20
EP17182422.0 2017-07-20

Publications (1)

Publication Number Publication Date
WO2019015814A1 true WO2019015814A1 (fr) 2019-01-24

Family

ID=59384003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/058219 WO2019015814A1 (fr) 2017-07-20 2018-03-29 Utilisation de protéine-1 de type chitinase-3 (chi3l1) en tant qu'auto-antigène dans des troubles auto-immuns du système digestif

Country Status (1)

Country Link
WO (1) WO2019015814A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006293A1 (fr) 1997-07-31 1999-02-11 Southcorp Australia Pty. Ltd. Bouchon en polyethylene pour recipient
WO1999056126A2 (fr) 1998-04-27 1999-11-04 Affina Immuntechnik Gmbh Matrice d'immuno-adsorption, ses procedes de production et son utilisation
WO2002026292A1 (fr) 2000-09-28 2002-04-04 Affina Immuntechnik Gmbh Dispositif de circulation destine a separer des substances dans des liquides corporels, en particulier dans le sang, et utilisation de ce dispositif
WO2002038592A2 (fr) 2000-11-08 2002-05-16 Affina Immuntechnik Gmbh Peptides, leur fabrication et leur utilisation pour la liaison des immunoglobulines
EP2913675A2 (fr) 2014-02-28 2015-09-02 GA Generic Assays GmbH Isoformes GP2 et leur utilisation dans la capture d'auto-anticorps

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006293A1 (fr) 1997-07-31 1999-02-11 Southcorp Australia Pty. Ltd. Bouchon en polyethylene pour recipient
WO1999056126A2 (fr) 1998-04-27 1999-11-04 Affina Immuntechnik Gmbh Matrice d'immuno-adsorption, ses procedes de production et son utilisation
WO2002026292A1 (fr) 2000-09-28 2002-04-04 Affina Immuntechnik Gmbh Dispositif de circulation destine a separer des substances dans des liquides corporels, en particulier dans le sang, et utilisation de ce dispositif
WO2002038592A2 (fr) 2000-11-08 2002-05-16 Affina Immuntechnik Gmbh Peptides, leur fabrication et leur utilisation pour la liaison des immunoglobulines
EP2913675A2 (fr) 2014-02-28 2015-09-02 GA Generic Assays GmbH Isoformes GP2 et leur utilisation dans la capture d'auto-anticorps

Non-Patent Citations (80)

* Cited by examiner, † Cited by third party
Title
A. BU-ISSON ET AL., ALIMENTARY PHARMACOLOGY & THERAPEUTICS., vol. 43, no. 10, 8 March 2016 (2016-03-08), pages 1069 - 1079
A. BUISSON ET AL: "Faecal chitinase 3-like 1 is a reliable marker as accurate as faecal calprotectin in detecting endoscopic activity in adult patients with inflammatory bowel diseases", ALIMENTARY PHARMACOLOGY & THERAPEUTICS., vol. 43, no. 10, 8 March 2016 (2016-03-08), GB, pages 1069 - 1079, XP055403209, ISSN: 0269-2813, DOI: 10.1111/apt.13585 *
ALVAREZ F; BERG PA; BIANCHI FB; BIANCHI L; BURROUGHS AK; CANCADO EL ET AL.: "International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis", J HEPATOL., vol. 31, no. 5, 1 November 1999 (1999-11-01), pages 929 - 38, XP055403358
ANDREW CAMPBELL: "Autoimmunity and the Gut.", AUTOIMMUNE DISEASES, vol. 2014, pages 12
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1999, JOHN WILEY & SONS, INC.
BAO, J. CHROMATOGR. B. BIOMED. SCI., vol. 699, 1997, pages 463 - 480
BAUMGART DC; SANDBORN WJ: "Crohn's disease", THE LANCET, vol. 380, no. 9853, 9 November 2012 (2012-11-09), pages 1590 - 605
BIGG HF; WAIT R; ROWAN AD; CAWSTON TE: "The Mammalian Chitinase-like Lectin, YKL-40, Binds Specifically to Type I Collagen and Modulates the Rate of Type I Collagen Fibril Formation", J BIOL CHEM., vol. 281, no. 30, 28 July 2006 (2006-07-28), pages 21082 - 95
BOOT RG; ACHTERBERG TAE VAN; AKEN BE VAN; RENKEMA GH; JACOBS MJHM; AERTS JMFG ET AL.: "Strong Induction of Members of the Chitinase Family of Proteins in Atherosclerosis", ARTE-RIOSCLER THROMB VASC BIOL., vol. 19, no. 3, 1 March 1999 (1999-03-01), pages 687 - 94, XP000874580
COFFMAN F D, CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCE, vol. 45, no. 6, 1 January 2008 (2008-01-01), pages 531 - 562
COFFMAN F D: "Chitinase 3-Like-1 (CHI3L1): a putative disease marker at the interface of proteomics and glycomics", CRITICAL REVIEWS IN CLINICAL LABORATORY SCIEN, CRC PRESS, BACA RATON, FL, US, vol. 45, no. 6, 1 January 2008 (2008-01-01), pages 531 - 562, XP008110639, ISSN: 1040-8363, DOI: 10.1080/10408360802334743 *
COJOCARU ET AL., MAEDICA (BUCHAR, vol. 6, no. 1, January 2011 (2011-01-01), pages 45 - 51
CONRAD ET AL., AUTOIMMUNITY REVIEWS, vol. 13, no. 4-5, 1 April 2014 (2014-04-01), pages 463 - 466
CONRAD K; ROGGENBUCK D; LAASS MW: "Diagnosis and classification of ulcerative colitis", AUTOIMMUN REV, vol. 13, 2014, pages 463 - 6, XP055403526, DOI: doi:10.1016/j.autrev.2014.01.028
DANESE S; FIOCCHI C.: "Ulcerative Colitis", N ENGL J MED., vol. 365, 3 November 2011 (2011-11-03), pages 1713 - 25
DE CEUNINCK F; GAUFILLIER S; BONNAUD A; SABATINI M; LESUR C; PASTOUREAU P: "YKL-40 (Carti-lage gp-39) Induces Proliferative Events in Cultured Chondrocytes and Synoviocytes and In-creases Glycosaminoglycan Synthesis in Chondrocytes", BIOCHEM BIOPHYS RES COMMUN, vol. 285, no. 4, 27 July 2001 (2001-07-27), pages 926 - 31
ELKE M. HENNES ET AL: "Simplified criteria for the diagnosis of autoimmune hepatitis", HEPATOLOGY, vol. 48, no. 1, 1 July 2008 (2008-07-01), pages 169 - 176, XP055403359, ISSN: 0270-9139, DOI: 10.1002/hep.22322 *
EVANS ET AL., J. MED. CHEM., vol. 30, 1987, pages 1229
FAUCHERE, ADV. DRUG RES., vol. 15, 1986, pages 29
FINK ET AL., J. CLIN. CHEM. CLIN. BIOL. CHEM., vol. 27, 1989, pages 261 - 276
FUSETTI F; PIJNING T; KALK KH; BOS E; DIJKSTRA BW: "Crystal Structure and Carbohydrate-binding Properties of the Human Cartilage Glycoprotein-39", J BIOL CHEM., vol. 278, no. 39, 26 September 2003 (2003-09-26), pages 37753 - 60
HAKALA BE; WHITE C; RECKLIES AD: "Human cartilage gp-39, a major secretory product of ar-ticular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family", J BIOL CHEM., vol. 268, no. 34, 5 December 1993 (1993-12-05), pages 25803 - 10
HANAUER ET AL., AM. J. GASTROENTEROL., vol. 92, 1997, pages 559 - 566
HASHIDA ET AL., J. CLIN. LAB. ANAL., vol. 11, 1997, pages 267 - 86
HENNES EM; ZENIYA M; CZAJA AJ; PARES A; DALEKOS GN; KRAWITT EL ET AL.: "Simplified criteria for the diagnosis of autoimmune hepatitis", HEPATOLOGY, vol. 48, no. 1, 1 July 2008 (2008-07-01), pages 169 - 76, XP055403359, DOI: doi:10.1002/hep.22322
HENNES ET AL., HEPATOLOGY, vol. 48, no. 1, 1 July 2008 (2008-07-01), pages 169 - 176
HUEBER ET AL., ARTHRITIS & RHEUMA, vol. 52, no. 9, 1 September 2005 (2005-09-01), pages 2645 - 2655
HUEBER WOLFGANG ET AL: "Antigen microarray profiling of autoantibodies in rheumatoid arthritis", ARTHRITIS & RHEUMA, WILEY INTERSCIENCE, US, vol. 52, no. 9, 1 September 2005 (2005-09-01), pages 2645 - 2655, XP009101906, ISSN: 0004-3591, DOI: 10.1002/ART.21269 *
JASKOWSKI TD; LITWIN CM; HILL HR: "Analysis of Serum Antibodies in Patients Suspected of Having Inflammatory Bowel Disease", CLIN VACCINE IMMUNOL., vol. 13, no. 6, 1 June 2006 (2006-06-01), pages 655 - 60
JEPSEN P; GRONBAEK L; VILSTRUP H.: "Worldwide Incidence of Autoimmune Liver Disease", DIG DIS., vol. 33, no. 2, 2015, pages 2 - 12
JOHANSEN JS; CHRISTOFFERSEN P; MOLLER S; PRICE PA; HENRIKSEN JH; GARBARSCH C ET AL.: "Serum YKL-40 is increased in patients with hepatic fibrosis", J HEPATOL., vol. 32, no. 6, June 2000 (2000-06-01), pages 911 - 20, XP002523835, DOI: doi:10.1016/S0168-8278(00)80095-1
JOHANSEN JS; JENSEN HS; PRICE PA: "A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid", BR J RHEUMATOL., vol. 32, no. 11, November 1993 (1993-11-01), pages 949 - 55, XP002041907, DOI: doi:10.1093/rheumatology/32.11.949
JOHANSEN JS; MILMAN N; HANSEN M; GARBARSCH C; PRICE PA; GRAUDAL N.: "Increased serum YKL-40 in patients with pulmonary sarcoidosis—a potential marker of disease activity?", RESPIR MED., vol. 99, no. 4, 1 April 2005 (2005-04-01), pages 396 - 402, XP004780205, DOI: doi:10.1016/j.rmed.2004.09.016
JOHANSEN JS; STOLTENBERG M; HANSEN M; FLORESCU A; HORSLEV-PETERSEN K; LORENZEN I ET AL.: "Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease ac-tivi-ty", RHEUMATOLOGY, vol. 38, no. 7, 1 July 1999 (1999-07-01), pages 618 - 26, XP002523828, DOI: doi:10.1093/rheumatology/38.7.618
JOHANSEN JS; WILLIAMSON MK; RICE JS; PRICE PA: "Identification of proteins secreted by human osteoblastic cells in culture", J BONE MINER RES OFF J AM SOC BONE MINER RES, vol. 7, no. 5, May 1992 (1992-05-01), pages 501 - 12
JOHANSEN JS; WILLIAMSON MK; RICE JS; PRICE PA: "Identification of proteins secreted by human osteoblastic cells in culture", J BONE MINER RES., vol. 7, no. 5, 1 May 1992 (1992-05-01), pages 501 - 12
JOOSSENS S; VERMEIRE S; VAN STEEN K; GODEFRIDIS G; CLAESSENS G; PIERIK M ET AL.: "Pancreatic autoantibodies in inflammatory bowel disease", INFLAMM BOWEL DIS., vol. 10, no. 6, 1 November 2004 (2004-11-01), pages 771 - 7
KARSTEN CONRAD ET AL: "Diagnosis and classification of ulcerative colitis", AUTOIMMUNITY REVIEWS, vol. 13, no. 4-5, 1 April 2014 (2014-04-01), NL, pages 463 - 466, XP055403526, ISSN: 1568-9972, DOI: 10.1016/j.autrev.2014.01.028 *
KELLEHER TB; MEHTA SH; BHASKAR R; SULKOWSKI M; ASTEMBORSKI J; THOMAS DL ET AL.: "Predic-tion of hepatic fibrosis in HIV/HCV co-infected patients using serum fibrosis markers: The SHASTA index", J HEPATOL., vol. 43, no. l, July 2005 (2005-07-01), pages 78 - 84
KOUTROUBAKIS ET AL., INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, vol. 18, no. 3, 1 May 2003 (2003-05-01), pages 254 - 259
KOUTROUBAKIS IE; PETINAKI E; DIMOULIOS P; VARDAS E; ROUSSOMOUSTAKAKI M; MANIATIS AN ET AL.: "Increased serum levels of YKL-40 in patients with inflammatory bowel disease", INT J COL-ORECTAL DIS., vol. 18, no. 3, 1 May 2003 (2003-05-01), pages 254 - 9
KOUTROUBAKIS IOANNIS E ET AL: "Increased serum levels of YKL-40 in patients with inflammatory bowel disease", INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, SPRINGER VERLAG, BERLIN, DE, vol. 18, no. 3, 1 May 2003 (2003-05-01), pages 254 - 259, XP002523829, ISSN: 0179-1958, [retrieved on 20021130], DOI: 10.1007/S00384-002-0446-Z *
KRUITHOF E; BAETEN D; DE RYCKE L; VANDOOREN B; FOELL D; ROTH J ET AL.: "Synovial histopathology of psoriatic arthritis, both oligo- and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis", ARTHRITIS RES THER., vol. 7, 2005, pages R569, XP021011589, DOI: doi:10.1186/ar1698
LAASS ET AL., AUTOIMMUNITY REVIEWS, vol. 13, no. 4-5, 1 April 2014 (2014-04-01), pages 467 - 471
LAASS MW; ROGGENBUCK D; CONRAD K.: "Diagnosis and classification of Crohn's disease", AUTOIMMUN REV, vol. 13, 2014, pages 467 - 71, XP055403529, DOI: doi:10.1016/j.autrev.2014.01.029
MALINDA KM; PONCE L; KLEINMAN HK; SHACKELTON LM; MILLIS AJT: "Gp38k, a Protein Synthe-sized by Vascular Smooth Muscle Cells, Stimulates Directional Migration of Human Um-bili-cal Vein Endothelial Cells", EXP CELL RES., vol. 250, no. 1, 10 July 1999 (1999-07-10), pages 168 - 73
MARTIN W. LAASS ET AL: "Diagnosis and classification of Crohn's disease", AUTOIMMUNITY REVIEWS, vol. 13, no. 4-5, 1 April 2014 (2014-04-01), NL, pages 467 - 471, XP055403529, ISSN: 1568-9972, DOI: 10.1016/j.autrev.2014.01.029 *
MATSUMOTO T; TSURUMOTO T.: "Serum YKL-40 Levels in Rheumatoid Arthritis: Correlations Between Clinical and Laborarory Parameters [Internet", PUBMED JOURNALS, 5 June 2017 (2017-06-05), Retrieved from the Internet <URL:https://ncbi.nlm.nih.gov/labs/articles/11791636>
MAZIERES B; GARNERO P; GUEGUEN A; ABBAL M; BERDAH L; LEQUESNE M ET AL.: "Molecular mark-ers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis", THE ECHODIAH* COHORT. ANN RHEUM DIS., vol. 65, no. 3, March 2006 (2006-03-01), pages 354 - 9
MIZOGUCHI E.: "Chitinase 3-Like-1 Exacerbates Intestinal Inflammation by Enhancing Bacterial Adhesion and Invasion in Colonic Epithelial Cells", GASTROENTEROLOGY, vol. 130, no. 2, February 2006 (2006-02-01), pages 398 - 411, XP005284543, DOI: doi:10.1053/j.gastro.2005.12.007
MONTAGNA GL; D'ANGELO S; VALENTINI G: "Cross-sectional evaluation of YKL-40 serum con-centrations in patients with systemic sclerosis. Relationship with clinical and serological aspects of disease", J RHEUMATOL., vol. 30, no. 10, 1 October 2003 (2003-10-01), pages 2147 - 51
MUNKHOLM P.: "Serum YKL-40, a Potential New Marker of Disease Activity in Patients with Inflammatory Bowel Disease", SCAND J GASTROENTEROL [INTERNET]. SCAND J GASTROENTEROL., vol. 38, no. 6, 1 January 2003 (2003-01-01), pages 599 - 605, XP009195376, DOI: doi:10.1080/00365520310000537
NISHIKAWA KC; MILLIS AJT: "gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells", EXP CELL RES., vol. 287, no. 1, 1 July 2003 (2003-07-01), pages 79 - 87, XP002584701, DOI: doi:10.1016/S0014-4827(03)00069-7
NORDENBAEK C; JOHANSEN JS; JUNKER P; BORREGAARD N; SORENSEN O; PRICE PA: "YKL-40, a Ma-trix Protein of Specific Granules in Neutrophils, Is Elevated in Serum of Patients with Com-munity-Acquired Pneumonia Requiring Hospitalization", J INFECT DIS., vol. 180, no. 5, 1 November 1999 (1999-11-01), pages 1722 - 6
NYIRKOS P; GOLDS EE: "Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period", BIOCHEM J., vol. 269, no. 1, 1 July 1990 (1990-07-01), pages 265 - 8
PANAYI GS: "Targeting of cells involved in the pathogenesis of rheumatoid arthritis", RHEUMATOL OXF ENGL., vol. 38, no. 2, November 1999 (1999-11-01), pages 8 - 10
PNAS USA, vol. 9521, 13 October 1998 (1998-10-13), pages 12179 - 84
RECKLIES AD; WHITE C; LING H.: "The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways", BIOCHEM J., vol. 365, 1 July 2002 (2002-07-01), pages 119 - 26, XP002382568, DOI: doi:10.1042/BJ20020075
REHLI M; KRAUSE SW; ANDREESEN R: "Molecular Characterization of the Gene for Human Carti-lage gp-39 (CHI3L1), a Member of the Chitinase Protein Family and Marker for Late Stages of Macrophage Differentiation", GENOMICS, vol. 43, no. 2, 15 July 1997 (1997-07-15), pages 221 - 5
RENKEMA GH; BOOT RG; AU FL; DONKER-KOOPMAN WE; STRIJLAND A; MUIJSERS AO ET AL.: "Chi-totriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages", EUR J BIO-CHEM, vol. 251, no. 1-2, 1 January 1998 (1998-01-01), pages 504 - 9
ROGGENBUCK D; HAUSDORF G; MARTINEZ-GAMBOA L; REINHOLD D; BUTTNER T; JUNGBLUT PR ET AL.: "Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's disease", GUT., vol. 58, no. 12, 1 December 2009 (2009-12-01), pages 1620 - 8
ROGGENBUCK D; REINHOLD D; BAUMGART DC; SCHIERACK P; CONRAD K; LAASS MW: "Autoimmunity in Crohn's Disease-A Putative Stratification Factor of the Clinical Phenotype", ADV CLIN CHEM, vol. 77, 2016, pages 77 - 101
ROGGENBUCK D; REINHOLD D; SCHIERACK P; BOGDANOS DP; CONRAD K; LAASS MW: "Crohn's disease specific pancreatic antibodies: clinical and pathophysiological challenges", CLIN CHEM LAB MED, vol. 52, 2014, pages 483 - 94, XP055130857, DOI: doi:10.1515/cclm-2013-0801
ROGGENBUCK D; REINHOLD D; WERNER L; SCHIERACK P; BOGDANOS DP; CONRAD K.: "Glycoprotein 2 in Crohn's disease", ADV CLIN CHEM, vol. 60, 2013, pages 187 - 208
RONGEN ET AL., J. IMMUNOL. METHODS, vol. 204, 1997, pages 105 - 133
SCHMALZING ET AL., ELECTROPHORESIS, vol. 18, 1997, pages 2184 - 2193
SELF ET AL., CURR. OPIN. BIOTECHNOL., vol. 7, 1996, pages 60 - 65
SHACKEL NA; MCGUINNESS PH; ABBOTT CA; GORRELL MD; MCCAUGHAN GW: "Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization", HEPATOL BALTIM MD., vol. 38, no. 3, September 2003 (2003-09-01), pages 577 - 88, XP002357884, DOI: doi:10.1053/jhep.2003.50376
SHACKELTON LM; MANN DM; MILLIS AJT: "Identification of a 38-kDa Heparin-binding Glycoprotein (gp38k) in Differentiating Vascular Smooth Muscle Cells as a Member of a Group of Proteins Associated with Tissue Remodeling", J BIOL CHEM., vol. 270, no. 22, 2 June 1995 (1995-06-02), pages 13076 - 83, XP002039027, DOI: doi:10.1074/jbc.270.22.13076
TRAN A; BENZAKEN S; SAINT-PAUL MC; GUZMAN-GRANIER E; HASTIER P; PRADIER C ET AL.: "Chon-drex (YKL-40), a potential new serum fibrosis marker in patients with alcoholic liver disease", EUR J GASTROENTEROL HEPATOL., vol. 12, no. 9, September 2000 (2000-09-01), pages 989 - 93
TRUELOVE ET AL., BR. MED. J., vol. 12, 1955, pages 1041 - 1048
VEBER; FREIDINGER, TINS, 1985, pages 392
VERHEIJDEN ET AL., ARTHRITIS & RHEUMATISM, vol. 40, no. 6, 1 June 1997 (1997-06-01), pages 1115 - 1125
VERHEIJDEN G F M ET AL: "HUMAN CARTILAGE GLYCOPROTEIN-39 AS A CANDIDATE AUTOANTIGEN IN RHEUMATOID ARTHRITIS", ARTHRITIS & RHEUMATISM, WILEY INTERSCIENCE, US, vol. 40, no. 6, 1 June 1997 (1997-06-01), pages 1115 - 1125, XP002039029, ISSN: 0004-3591 *
VOLCK B; JOHANSEN JS; STOLTENBERG M; GARBARSCH§ C; PRICE PA; 0STERGAARD M ET AL.: "Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology", OSTEOARTHRITIS CARTILAGE, vol. 9, no. 3, 1 April 2001 (2001-04-01), pages 203 - 14
VOLCK B; OSTERGAARD K; JOHANSEN JS; GARBARSCH C; PRICE PA: "The distribution of YKL-40 in osteoarthritic and normal human articular cartilage", SCAND J RHEUMATOL., vol. 28, no. 3, 1999, pages 171 - 9
WASHINGTON M: "Autoimmune liver disease: overlap and outliers", MODERN PATHOLOGY, vol. 20, 2007, pages S15 - S30
YUSUF ERZIN ET AL., JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 23, 1 August 2008 (2008-08-01), pages e357 - e362
YUSUF ERZIN ET AL: "Serum YKL-40 as a marker of disease activity and stricture formation in patients with Crohn's disease", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 23, no. 8pt2, 1 August 2008 (2008-08-01), AU, pages e357 - e362, XP055403215, ISSN: 0815-9319, DOI: 10.1111/j.1440-1746.2007.05121.x *
ZHENG M; WEI-MIN C; JUN-KANG Z; SHAO-MING Z; RONG-HUA L: "Determination of serum lev-els of YKL-40 and hyaluronic acid in patients with hepatic fibrosis due to schistosomiasis japonica and appraisal of their clinical value", ACTA TROP., vol. 96, no. 2-3, November 2005 (2005-11-01), pages 148 - 52

Similar Documents

Publication Publication Date Title
JP5603083B2 (ja) 炎症性大腸炎及び慢性膵炎の診断のために、膵臓の酵素原顆粒由来の糖タンパク質2(gp2)との免疫反応を介して体液から抗体を検出する方法
WO2010041892A9 (fr) Nouvelle utilisation du polypeptide aimp1
JP5728743B2 (ja) 関節リウマチの診断のためのバイオマーカー、方法およびキット
US9012405B2 (en) Citrullinated fibrin-filaggrin chimeric polypeptide capable of detecting the antibodies generated in rheumatoid arthritis
CA3033035C (fr) Methode de diagnostic de pancreatite aigue (ap) par detection d&#39;isoforme alpha de glycoproteine 2 (gp2a)
EP2913675B1 (fr) Isoformes GP2 et leur utilisation dans la capture d&#39;auto-anticorps
JPS62501563A (ja) リウマチ性関節炎の特徴である蛋白質
US8445215B1 (en) Assays and methods for the detection of Crohn&#39;s disease
KR20020021813A (ko) 이성질화된/임의로 반전된 에피토프에 대한 특이성자가면역 반응: 자가면역 질환 진단의 응용
JP5231477B2 (ja) 関節炎の診断および治療のためのグルコース−6−ホスフェートイソメラーゼおよびその抗体の使用、ならびに抗関節炎化合物の試験
WO2019015814A1 (fr) Utilisation de protéine-1 de type chitinase-3 (chi3l1) en tant qu&#39;auto-antigène dans des troubles auto-immuns du système digestif
JP5280214B2 (ja) 炎症性腸疾患の診断方法
US11340235B2 (en) GP2 isoforms and their use in autoantibody capture
Wiik Anti-neutrophil cytoplasmic antibodies tests: which tests should be used in practice?
CN108948173B (zh) 一种瓜氨酸修饰肽及其应用
JP2008249618A (ja) 外分泌障害診断薬
Zurgil et al. Detection of antimitochondrial antibodies: characterization by enzyme immunoassay and immunoblotting
Manoussakis et al. Detection of human-specific anti-La (SSB) antibodies in patients with rheumatoid arthritis
US7566545B2 (en) Method for producing a nucleosome preparation and use thereof in in vitro diagnosis of disseminated lupus erythematosus (DLE)
JP2009014521A (ja) 睡眠時無呼吸症候群の診断方法
JPH08334513A (ja) インターフェロン療法後のc型慢性肝炎の予後判定

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18712930

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18712930

Country of ref document: EP

Kind code of ref document: A1