WO2018190432A1 - Procédé de production d'assemblage de capsule molle et assemblage de capsule molle - Google Patents

Procédé de production d'assemblage de capsule molle et assemblage de capsule molle Download PDF

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Publication number
WO2018190432A1
WO2018190432A1 PCT/JP2018/015591 JP2018015591W WO2018190432A1 WO 2018190432 A1 WO2018190432 A1 WO 2018190432A1 JP 2018015591 W JP2018015591 W JP 2018015591W WO 2018190432 A1 WO2018190432 A1 WO 2018190432A1
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WIPO (PCT)
Prior art keywords
nozzle
soft capsule
oil
acid
liquid
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PCT/JP2018/015591
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English (en)
Japanese (ja)
Inventor
セルジオ 石場
美緒 近藤
西村　剛一
義之 下川
康範 岩尾
晋一郎 木村
茂 板井
Original Assignee
富士カプセル株式会社
静岡県公立大学法人
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Application filed by 富士カプセル株式会社, 静岡県公立大学法人 filed Critical 富士カプセル株式会社
Priority to JP2019512586A priority Critical patent/JP7093973B2/ja
Publication of WO2018190432A1 publication Critical patent/WO2018190432A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q13/00—Formulations or additives for perfume preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q9/00—Preparations for removing hair or for aiding hair removal
    • A61Q9/02—Shaving preparations

Definitions

  • the present invention relates to a method for producing a soft capsule aggregate capable of producing a soft capsule aggregate having an average particle diameter of 800 ⁇ m or less and a soft capsule aggregate having an average particle diameter of 800 ⁇ m or less encapsulated with a gelatin film.
  • Soft capsules are widely used in fields such as pharmaceuticals, foods, cosmetics, and agricultural chemicals. In recent years, reducing the particle size of soft capsules improves the uniformity of mixing when blended into powders, granulated products, and high-viscosity products, and also improves the texture and texture. Therefore, a microcapsule having a smaller particle size than the conventional one is required.
  • Soft capsule manufacturing methods include a rotary method in which two film-forming sheets are punched and formed, a liquid that fills the capsule from the inner nozzle using a double nozzle, and a film that forms the capsule film from the outer nozzle A dropping method in which liquids are simultaneously discharged and dropped into a curable liquid is known (Patent Document 1).
  • the dripping method can produce soft capsules with a smaller particle size than the rotary method, but the soft capsules that can be produced still have a particle size of 2 to 10 mm, and produce soft capsules of micron order with a particle size of less than 1 mm. Was difficult. Also, in order to produce a three-layered soft capsule as a dripping method, the content liquid is discharged from the inner nozzle using the triple nozzle, the protective liquid is discharged from the intermediate nozzle, and the coating liquid is discharged simultaneously from the outer nozzle into the hardening liquid. Although a dripping method has been proposed (Patent Document 2), the particle diameter of the obtained soft capsule was not different from that of the double nozzle.
  • An object of the present invention is to solve the above problems and provide a soft capsule manufacturing method capable of manufacturing a soft capsule having a particle size of less than 1 mm and having a particle size of less than 1 mm, and a soft capsule aggregate having a particle size of a micron order.
  • the present inventors have started studying a method for producing soft capsules having a particle size of micron order. While proceeding with the study, the inventors of the present invention used a triple nozzle to discharge a film solution for forming a film from the outermost nozzle, whether it is a double nozzle or a triple nozzle. Then, the content liquid that becomes the contents of the capsule is discharged from the inner nozzle, the coating liquid is discharged from the intermediate nozzle, and the medium-chain fatty acid triglyceride (MCT) that is not a constituent component of the capsule is discharged from the outermost nozzle. It was discharged.
  • MCT medium-chain fatty acid triglyceride
  • the liquid droplets formed by the content liquid and the coating liquid can be made minute by the action of the discharge liquid from the outermost nozzle, and a soft capsule having a particle diameter of less than 1 mm can be produced.
  • a soft capsule aggregate having an average particle size of 800 ⁇ m or less, 700 ⁇ m or less, 600 ⁇ m or less, 500 ⁇ m or less, 400 ⁇ m or less, 300 ⁇ m or less, 200 ⁇ m or less, or 100 ⁇ m or less.
  • the present invention has been completed based on the above findings.
  • the present invention is specified by the following items.
  • (1) Using a triple nozzle comprising an inner nozzle, an intermediate nozzle outside the inner nozzle, and an outer nozzle outside the intermediate nozzle, the content liquid from the inner nozzle, the coating liquid from the intermediate nozzle, and the outer nozzle from the outer nozzle A method for producing a soft capsule aggregate having an average particle size of 800 ⁇ m or less, wherein a carrier liquid is discharged to form droplets, and the coating liquid of the droplets is cured.
  • the discharge speed of the content liquid is 0.1 to 7.5 ml / hr
  • the discharge speed of the coating liquid is 0.1 to 13.0 ml / hr
  • the discharge speed of the carrier liquid is 0.1 to 6
  • the method for producing a soft capsule aggregate according to the above (1), wherein the production rate is 0.0 ml / min.
  • a soft capsule aggregate characterized in that it is an aggregate of soft capsules whose contents are encapsulated by a film containing gelatin and having an average particle diameter of 800 ⁇ m or less.
  • a soft capsule aggregate having an average particle diameter of 800 ⁇ m or less can be produced. Moreover, the particle diameter of the soft capsule aggregate produced can be adjusted. According to the production method of the present invention, a soft capsule having a spherical shape, a smooth surface, and sufficient hardness can be produced. Since the soft capsule aggregate of the present invention is an aggregate of soft capsules having an average particle size of 800 ⁇ m or less, it has excellent mixing uniformity when blended into powders, granulated products and high-viscosity products. It is excellent in texture and texture when used. In particular, when blended in a granulated product, uniformity can be further improved by aligning the particle size of the granulated product with the particle size of the soft capsule aggregate.
  • FIG. 1 It is a schematic diagram which shows one Embodiment of the triple nozzle used with the manufacturing method of this invention. It is a schematic diagram which shows one Embodiment of the manufacturing method of this invention, and subsequent washing
  • 6 is a SEM image of a soft capsule obtained in Example 5.
  • 7 is a SEM image of a soft capsule obtained in Example 6.
  • 10 is a SEM image of the soft capsule obtained in Example 7. It is a figure which shows the particle size distribution of the soft capsule obtained in Example 11.
  • the soft capsule manufacturing method of the present invention uses a triple nozzle comprising an inner nozzle, an intermediate nozzle outside the inner nozzle, and an outer nozzle outside the intermediate nozzle, and the content liquid from the inner nozzle and the coating liquid from the intermediate nozzle.
  • the carrier liquid is discharged from the outer nozzle to form droplets, and the coating liquid of the droplets is cured.
  • an intermediate nozzle is provided outside the inner nozzle so as to surround the inner nozzle
  • an outer nozzle is provided outside the intermediate nozzle so as to surround the intermediate nozzle.
  • each nozzle is not particularly limited, but from the viewpoint of uniforming the thickness of the coating without uneven distribution of contents, the shape of the discharge port of each nozzle is preferably annular, and each nozzle is arranged concentrically. More preferred. In addition, the discharge port end faces of the nozzles may or may not be aligned.
  • the discharge port of the inner nozzle is slightly inside (indented) slightly from the discharge port of the intermediate nozzle, and the discharge port of the intermediate nozzle is slightly inward (inside) the discharge port of the outer nozzle. It is desirable to be in
  • the flow rate of the liquid ejected from each nozzle in the manufacturing method of the present invention is set so that the liquid droplets ejected from the inner nozzle have a flow rate of 0.
  • 1 to 7.5 ml / hr is preferable.
  • Examples of the flow rate of the content liquid included in this range include 0.2 to 5.0 ml / hr, 0.5 to 5.0 ml / hr, and 0.2 to 3.0 ml / hr.
  • the flow rate of the coating liquid discharged from the intermediate nozzle is preferably 0.1 to 13.0 ml / hr.
  • the flow rate of the coating liquid included in this range is 0.2 to 13.0 ml / hr, 2.0 to 13.0 ml / hr, 0.2 to 12.0 ml / hr, 5.0 to 12.0 ml / hr and the like are exemplified.
  • the flow rate of the carrier liquid discharged from the outer nozzle is preferably 0.1 to 6.0 ml / min.
  • the flow rate of the carrier liquid included in this range is 0.1 to 5.0 ml / min, 0.1 to 4.0 ml / min, 0.1 to 3.0 ml / min, 0.2 to 6.0 ml / min. min, 0.2-5.0 ml / min, 0.2-4.0 ml / min, 0.2-3.0 ml / min, 0.3-5.0 ml / min, 0.3-4.0 ml / min
  • Examples include min, 0.3 to 3.0 ml / min, 1.0 to 6.0 ml / min, 2.0 to 5.0 ml / min.
  • the flow rate is a flow rate discharged from each nozzle per unit time, and is also referred to as a discharge speed in the present specification.
  • the flow rate of the carrier liquid discharged from the outer nozzle is preferably larger than the flow rate of the content liquid discharged from the inner nozzle or the flow rate of the coating liquid discharged from the intermediate nozzle, and the flow rate of the liquid discharged from each nozzle.
  • the ratio of (discharge speed) the ratio of the flow rate of the coating liquid to the flow rate of the content liquid is preferably 0.1 to 50.0.
  • the ratio of the flow rate of the coating liquid to the flow rate of the content liquid included in this range is 0.1 to 40, 0.1 to 30, 0.1 to 20, 0.1 to 10, 0.5 to 50, 0.
  • the ratio of the flow rate of the carrier liquid to the flow rate of the coating liquid is preferably 12.0 to 600.0.
  • the ratio of the flow rate of the carrier liquid to the flow rate of the coating liquid included in this range is 12 to 500, 12 to 400, 12 to 300, 12 to 200, 12 to 100, 12 to 60, 50 to 600, 50 to 500. , 50-400, 50-300, 50-200, 50-100 and the like.
  • the area of the opening of the discharge port of the inner nozzle is preferably 7500 to 32000 ⁇ m 2 .
  • the area of the opening of the intermediate nozzle is preferably 25 to 100 times the area of the opening of the inner nozzle.
  • the area of the opening of the discharge port of the outer nozzle is preferably 7500 to 38000 ⁇ m 2 .
  • minute droplets in which the content liquid is encapsulated by the coating liquid are formed by the action of the carrier liquid.
  • the flow rate of the content liquid discharged from the inner nozzle is 0.1 to 7.5 ml / hr
  • the flow rate of the coating liquid discharged from the intermediate nozzle is 0.1 to 13.0 ml / hr.
  • the average particle size is 400 ⁇ m or less, 300 ⁇ m or less, 200 ⁇ m or less, 100 ⁇ m or less, 10 to 400 ⁇ m, 10 to 300 ⁇ m. It is preferably used for producing soft capsules of 10 to 200 ⁇ m, 10 to 100 ⁇ m, 50 to 400 ⁇ m, 50 to 300 ⁇ m, 50 to 200 ⁇ m, or 50 to 100 ⁇ m.
  • a soft capsule is manufactured by curing the coating liquid of the formed droplet.
  • the coating liquid may be cured by discharging the droplets into a gas and cooling to gel the coating liquid and curing it, or dropping the droplets into a curing liquid that gels the coating liquid to gel the film. It may be cured.
  • the carrier liquid and the curable liquid remaining on the film can be removed by washing as necessary, and by drying this, the microparticles as dry powder can be obtained.
  • a capsule assembly is obtained.
  • the particle diameter can be controlled by appropriately adjusting the flow rate, flow rate, viscosity, etc.
  • microcapsule aggregate having an average particle size of 800 ⁇ m or less, 700 ⁇ m or less, 600 ⁇ m or less, 500 ⁇ m or less, 400 ⁇ m or less, 300 ⁇ m or less, 200 ⁇ m or less, or 100 ⁇ m or less is manufactured.
  • Particles with a particle size of the order of microns are usually handled as aggregates, so-called powders, rather than being handled one by one, and in this case, the particle size is generally expressed as an average particle size.
  • the soft capsule aggregate in the present invention means a collection of a plurality of soft capsules, and does not mean an integrated or a specific rule.
  • the average particle size is analyzed with an image analysis software (WinROOF, Mitani Sangyo Co., Ltd.) with 50 or more samples (N number) using an image taken with a microscope digital camera (DP010, Olympus Optical Industry). Can be obtained.
  • the soft capsules produced by the production method of the present invention can be used for various uses such as pharmaceuticals, foods, cosmetics, and agricultural chemicals, and the composition of the content liquid in the present invention is appropriately determined according to the use.
  • Examples of the capsule content contained in the content liquid in the present invention are illustrated below, but are not limited thereto, and include a solvent as necessary.
  • the content liquid may be in the form of a solution or a suspension.
  • waxes and waxes shellac wax, beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, cyclic lanolin, lanolin wax, candelilla wax, molasses, montan wax, shellac wax, rice wax, etc.
  • the hardened oil it is possible to contain a hardened vegetable oil obtained by hydrogenating vegetable fats, hardened beef fat, hardened tallow oil, and the like.
  • lecithins examples include egg yolk lecithin, soybean lecithin, enzyme-degraded lecithin (lysolecithin), phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, dicetylphosphate, stearylamine, phosphatidylglycerol, phosphatidic acid, phosphatidylinositol amine, cardiolipin, Ceramide phosphoryl ethanolamine, ceramide phosphoryl glycerol and the like can be contained.
  • the enzymatically decomposed lecithin is obtained, for example, by allowing phospholipase A 2 to act on egg yolk lecithin or soybean lecithin.
  • mineral oil liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax and the like can be contained.
  • fatty acids lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, conjugated linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil , Natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid and the like, and fats and oils containing these fatty acids as fatty acid composition Etc. can be contained.
  • vitamin A group retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: fursultiamine, thiamine hydrochloride, thiamine sulfate (vitamin B1 ), Riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin, methylcobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: ascorbic acid or its derivatives, Vitamin D group: Ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin) K1), menaquinone (vitamin K2), menate
  • pepper tincture red pepper oil, nonyl acid vanillamide, cantalis tincture, ginger tincture, ginger oil, mint oil, l-menthol, camphor, benzyl nicotinate, and the like can be contained.
  • benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium, dihydroxydimethoxy Benzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.
  • paraaminobenzoic acid derivatives paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, para Octyl dimethylaminobenzoate
  • methoxycinnamate derivatives ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, paramethoxycinnamon
  • whitening agents paraaminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acids Derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin , Baicalin, baicalein, berberine, placenta extract, ellagic acid, lucinol and the like.
  • tyrosinase activity inhibitors include vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or derivatives thereof (hydroquinone benzyl ether, etc.), kojic acid or derivatives thereof, vitamin E or derivatives thereof, N -Acetyltyrosine or its derivatives, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camomile, mulberry, gardenia, touki, firewood, clara, mugwort, honeysuckle, Yellowfin, Butterflies, Pine-hod, Barley, Oyster, Hops, Hawthorn, Eucalyptus, Achillea millefolium, Artea, Keihi, Mankeishi, Hamamelis, Karaguawa or Yamaguwa, Life-surviving grass, bellflower, Toshishi
  • phenylmercury hexachlorophene As a melanin reduction or decomposition substance, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or a derivative thereof can be contained.
  • hydroquinone As a turnover promoting action and cell activator, hydroquinone, lactic acid bacteria extract, placenta extract, ganoderma extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, ougone) , Horsetail, gentian, burdock, shikon, carrot, hamamelis, hops, yokoinin, mandarin duck, sea bream, pearl millet, red snapper, achacha, hypericum, cucumber, red pepper, mannen wax, parsley) and the like.
  • succinic acid As astringents, succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds), etc. can be included is there.
  • SOD active oxygen scavenger
  • catalase catalase
  • glutathione peroxidase glutathione peroxidase
  • Anti-inflammatory agents include ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its salts , Glycyrrhetinic acid or a salt thereof, licorice extract, coconut extract, age extract, propolis and the like.
  • Antibacterial, bactericidal and antiseptics include acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolysates thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salashi Powder, iodine compound, iodoform, sorbic acid or salt thereof, propionic acid or salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p- Chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, Irgasan CH3565,
  • glycerin As humectants, glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprycapric acid, glycolic acid ( ⁇ -hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or Derivatives or chitosan derivatives, pyrrolidone carboxylic acid or salts thereof, sodium lactate, urea, sorbitol, amino acids or derivatives thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine Cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine,
  • glycolic acid citric acid, malic acid, tartaric acid, lactic acid, ferulic acid, phytic acid and the like can be contained.
  • selenium disulfide for hair, selenium disulfide, alkylisoquinolinium bromide, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, pepper tincture, quinine hydrochloride, strong ammonia water, potassium bromate, sodium bromate, thioglycol It can contain an acid or the like.
  • natural animal fragrances such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin Essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, large Perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trout balsam essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, persimmon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil
  • fish oil, garlic, vitamin B1 so-called egg oil (brown to black liquid obtained by heating in low heat for a long time using an iron pan etc. with stirring egg yolk, a traditional health food material) Etc.
  • the film liquid in the present invention can contain a film component usually used as a film of a soft capsule, and can contain a solvent such as water as necessary.
  • the film component is not particularly limited, and may be a hydrophobic film component or a hydrophilic film component, but is preferably a hydrophilic film component.
  • hydrophilic film components include gelatin, modified gelatin such as succinated gelatin, carrageenan, agar, sodium alginate, pullulan, glucomannan, gum arabic, fur cerelan, yukema algae, gellan gum, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinylpyrrolidone,
  • modified gelatin such as succinated gelatin, carrageenan, agar, sodium alginate, pullulan, glucomannan, gum arabic, fur cerelan, yukema algae, gellan gum, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinylpyrrolidone
  • One or a combination of two or more hydrophilic polymers such as polyvinyl alcohol and starch can be exemplified, and gelatin or modified gelatin can be preferably exemplified.
  • the film components include plasticizers such as glycerin, sorbitol, propylene glycol and polyethylene glycol, light-shielding agents such as titanium dioxide, pH adjusters such as sodium phosphate, chelating agents such as trisodium citrate and sodium metaphosphate, lactic acid Gelling accelerators such as calcium and potassium chloride, surfactants such as polyglycerin fatty acid ester and lecithin, flavoring agents, fragrances, preservatives, colorants, dissolution aids and the like may be added.
  • various starches including modified starch, modified starch, starch, and starch degradation product
  • various polysaccharides can also be contained as a film shaper.
  • gelatin used in the coating solution of the present invention examples include, for example, cattle, pigs, chickens, fish skin, bones, tendons, etc. as raw materials, and heat extraction of crude collagen obtained by treatment with acid or alkali. Can be mentioned.
  • modified gelatin such as gelatin hydrolyzate, enzyme degradation product, succinylated gelatin, and phthalated gelatin can also be used. Any kind of gelatin can be preferably used.
  • the jelly strength of gelatin is preferably 100 to 300 g, and more preferably 130 to 250 g. The jelly strength can be measured according to JISK-6503 (2001).
  • the gelatin content is preferably 1.0 to 10.0% by mass, more preferably 2.0 to 8.0% by mass with respect to water.
  • carrageenans in addition to gelatin as a film component contained in the film liquid.
  • the carrageenans used in the coating solution in the present invention are a kind of galactan having a sulfate group and are known to exist in red algae.
  • Carrageenans can be classified into three types, iota carrageenan ( ⁇ carrageenan), kappa carrageenan ( ⁇ carrageenan), and lambda carrageenan ( ⁇ carrageenan), depending on the gelation characteristics and structure.
  • ⁇ carrageenan and ⁇ carrageenan are preferable from the viewpoint of gelation ability.
  • Carrageenans may be pure products or may contain standardized substances.
  • 1 type, or 2 or more types selected from the group which consists of saccharides, such as sucrose, glucose, maltose, and lactose, and dextrin is mentioned.
  • Sucrose and dextrin are preferred.
  • As the dextrin acid-decomposed dextrin and enzyme-degraded dextrin are preferable.
  • a blend raw material in which ⁇ carrageenan and ⁇ carrageenan are mixed in advance can also be used.
  • the content of carrageenan used together with gelatin in the coating solution is preferably 0.1 to 1.0% by mass, more preferably 0.1 to 0.8% by mass with respect to water.
  • gelling agents such as carrageenans, agar, and gellan gum can be used in place of gelatin as the film component contained in the film liquid, and gelation of dextrin and starch degradation products can be performed. Substances that do not inhibit the above can also be used in combination as thickeners or fillers. By using these gelling agents, problems such as adhesion can be improved.
  • the carrier liquid in the present invention is not particularly limited as long as it does not mix with the film liquid.
  • the film liquid contains a hydrophilic film component, various fats and oils, fatty acids, sugar fatty acid esters, aliphatic carbonization Examples include hydrophobic liquids such as hydrogen, aromatic hydrocarbons, chain ethers, higher fatty acid esters, higher alcohols, and terpenes.
  • Various animal and vegetable oils / synthetic oils / refined oils such as coconut oil, peanut oil, EPA, DHA, shark liver oil, cod liver oil, medium chain fatty acid triglyceride (MCT), diacylglycerol, liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, micro Mineral oils such as crystallin wax can be mentioned, and MCT can be preferably mentioned.
  • the coating solution is usually prepared by setting the solution temperature to 70 to 90 ° C.
  • the carrier temperature of the carrier solution can be adjusted to 15 to 25 ° C. (room temperature). It is preferable from the viewpoint of delaying the conversion rate and preventing the nozzle from clogging.
  • the liquid temperature of the content liquid is preferably about the same as the film liquid.
  • the curable liquid is not particularly limited as long as it does not mix with the coating liquid, and is exemplified by the carrier liquid. Things can be used. If the same component is used for the carrier liquid and the curable liquid, cleaning becomes easy.
  • the soft capsules having an average particle size of 800 ⁇ m or less according to the present invention have a very small particle size, so that even when added to foods, a texture that is not uncomfortable can be obtained. Therefore, volatilization and alteration of the contents can be prevented in the capsule until the time of eating, and a food that does not have a sense of incongruity of contaminants can be obtained at the time of eating.
  • the average particle size is preferably 500 ⁇ m or less, more preferably 400 ⁇ m or less, preferably 300 ⁇ m or less, more preferably 200 ⁇ m or less, and even more preferably 100 ⁇ m or less.
  • Examples of the average particle diameter included in this range include 10 to 400 ⁇ m, 10 to 300 ⁇ m, 10 to 200 ⁇ m, 10 to 100 ⁇ m, 50 to 400 ⁇ m, 50 to 300 ⁇ m, 50 to 200 ⁇ m, and 50 to 100 ⁇ m.
  • the soft capsule of the present invention since the soft capsule of the present invention has a small particle size, it can be uniformly mixed with a powder, a granulated product or a high viscosity product. Further, since the particle size of the soft capsule aggregate can be adjusted, it can be blended into various substrates without selecting the type of the substrate, the particle size of the powder, and the granulated product.
  • the soft capsule of the present invention is excellent in mixing uniformity with various base materials, it is monodispersed in base materials used in pharmaceuticals, foods, cosmetics, agricultural chemicals, etc. or processed products obtained by further processing base materials after mixing. It can exist in a state close to that. For example, when mixed in powder or granulated product, it can exist in a powder or granulated product as a single substance or in a state close to a single substance.
  • the soft capsule of the present invention in food, by mixing the soft capsule of the present invention with a high viscosity product such as a raw material for gum or dough for noodles, the soft capsule of the present invention is dispersed in the high viscosity product in a single state or a state close to a single unit, This is present in the same state in the solidified product.
  • a high viscosity product such as a raw material for gum or dough for noodles
  • the triple nozzle A includes an inner nozzle 1, an intermediate nozzle 2, and an outer nozzle 3.
  • the discharge port end surface of the inner nozzle 1 is provided at a position slightly behind the discharge port end surface of the intermediate nozzle 2, and the discharge port end surface of the intermediate nozzle 2 is from the discharge port end surface of the outer nozzle 3. It is provided in a slightly recessed position.
  • the content liquid 4, the coating liquid 5 and the carrier liquid 6 are sent to the inner nozzle 1, the intermediate nozzle 2 and the outer nozzle 3 by the pump 13, respectively. When each liquid is discharged from the nozzle, a droplet in which the content liquid 4 is encapsulated in the coating liquid 5 is formed.
  • the coating liquid 5 of the droplets is gelled and cured to prepare a soft capsule.
  • the state at the time of soft capsule molding can be observed by a monitor 11 connected to the microscope objective lens 9 and the CCD camera 10, and the particle size of the soft capsule can be controlled by adjusting various conditions based on the observation.
  • the soft capsule in the curable liquid 8 is filtered, washed, and then dried by freeze-drying or the like to obtain a dried soft capsule.
  • Examples 1 to 11 The concentric triple nozzle shown in FIG. 1 is used, and the inner nozzles contain the content liquid (liquid temperature: 20 ° C.) composed of MCT solution containing 0.1% of the synthetic colorant sudan III, and the intermediate nozzles are shown in Tables 1 to 3.
  • a coating liquid having the composition shown (liquid temperature: 80 ° C.) is discharged from the outer nozzle to form MCT (liquid temperature: 20 ° C.) to form a three-layer liquid droplet, and the three-layer liquid droplet is in the MCT liquid (liquid temperature: liquid temperature: 20 ° C.).
  • the obtained capsule was freeze-dried and washed to obtain a soft capsule.
  • the discharge speed of the content liquid is 1.0 ml / hr in Examples 1 to 10, 0.2 ml / hr in Example 11, and the discharge speed of the coating liquid is 10.0 ml / hr in Examples 1 to 10.
  • 11 was 0.2 ml / hr
  • the carrier liquid discharge speed was 3.0 ml / min in Examples 1 to 10, and 0.3 ml / min in Example 11.
  • the inner nozzle had an inner diameter of 250 ⁇ m
  • the intermediate nozzle had an inner diameter of 800 ⁇ m
  • the outer nozzle had an inner diameter of 1800 ⁇ m.
  • the following gelatin, kappa carrageenan and MCT were used.
  • the viscosity of the coating liquid of each formulation was measured using a cone plate viscometer (DV2T, Eihiro Seiki Co., Ltd.).
  • the ratio of the carrier liquid discharge speed to the coating liquid discharge speed was 18 in Examples 1 to 10 and 90 in Example 11.
  • Gelatin pig skin gelatin, manufactured by Zerais
  • Carrageenan Mitsubishi Corporation Foodtech
  • MCT Kio Corporation
  • Examples 12 to 25 Using the same concentric triple nozzle as used in Examples 1 to 11, a content liquid (liquid temperature: 20 ° C.) composed of an MCT solution containing 0.1% of the synthetic colorant sudanIII was used as an intermediate nozzle from the inner nozzle. , The coating liquid (liquid temperature: 80 ° C.) having the composition shown in Tables 4 to 7 is discharged from the outer nozzle, and MCT (liquid temperature: 20 ° C.) is discharged from the outer nozzle to form three-layer droplets. The solution was dropped into the MCT solution (liquid temperature: 20 ° C.). The obtained capsule was freeze-dried and washed to obtain a soft capsule.
  • the discharge speed of the content liquid and the discharge speed of the coating liquid were 0.2 ml / hr, and the discharge speed of the carrier liquid was the speed shown in Tables 4-7.
  • the ratio of the carrier liquid discharge speed to the coating liquid discharge speed was 90, 330, and 570 when the carrier liquid discharge speed was 0.3 ml / min, 1.1 ml / min, and 1.9 ml / min, respectively. .
  • FIGS. 3 is a soft capsule obtained in Example 5
  • FIG. 4 is a soft capsule obtained in Example 6
  • FIG. 5 is an SEM image of the soft capsule obtained in Example 7.
  • Soft capsules with a smooth particle surface were obtained by adding carrageenan to the coating (FIGS. 4 and 5).
  • Example 11 An image obtained by photographing the soft capsule obtained in Example 11 with a microscope digital camera (DP010, Olympus Optical Co., Ltd.) was measured from the image using the image analysis software ImageJ (registered trademark) 1.46r, and the particle diameter of the granulated product was measured. A particle size distribution was created based on the results. The particle size distribution is shown in FIG.
  • the span factor in Table 9 is an index represented by (particle diameter (d 90 ) in cumulative distribution 90% ⁇ particle diameter (d 10 ) in cumulative distribution 10%) / median diameter (d 50 ).
  • the fine soft capsules obtained by the production method of the present invention can be suitably used for foods, beverages, tobacco, cosmetics, agricultural chemicals and the like including pharmaceuticals, general foods, functional foods, health foods and the like. Examples of general foods include confectionery such as chewing gum, candy, jelly, and chocolate. Cosmetics include toiletries such as shaving lotions, soaps, creams and foams, colons, and deodorants.
  • agents include agents, antiperspirants, bath oils, shampoos, hair treatment compositions, conditioners, tanning lotions, talcum powders, face creams, hand creams, eye drops and the like.
  • it can be used as a suspension injection for subcutaneous injection or intramuscular injection
  • a flavor component or umami component to a food such as gum or noodles.

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Abstract

La présente invention concerne un procédé de production de capsules molles capables de produire des capsules molles ayant une taille de particule de l'ordre du micron inférieure à 1 mm, et un assemblage de capsule molle ayant une taille de particule de l'ordre du micron. L'invention concerne un procédé de production d'un assemblage de capsule molle ayant une taille de particule moyenne de 800 µm ou moins, caractérisé par l'utilisation d'une triple buse comprenant une buse interne, une buse intermédiaire sur le côté externe de la buse interne, et une buse externe sur le côté externe de la buse intermédiaire ; l'évacuation d'une solution de noyau depuis la buse interne, d'une solution de revêtement depuis la buse intermédiaire, et d'une solution de véhicule depuis la buse externe pour former des gouttelettes, et le durcissement de la solution d'enrobage des gouttelettes.
PCT/JP2018/015591 2017-04-14 2018-04-13 Procédé de production d'assemblage de capsule molle et assemblage de capsule molle WO2018190432A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021528043A (ja) * 2018-12-04 2021-10-21 ケーティー・アンド・ジー・コーポレーション 三重カプセル及びそれを製造する装置及び方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4422985A (en) * 1982-09-24 1983-12-27 Morishita Jintan Co., Ltd. Method and apparatus for encapsulation of a liquid or meltable solid material
JPH11509768A (ja) * 1995-03-29 1999-08-31 ワーナー−ランバート・カンパニー 継ぎ目なしカプセル
JP2004105282A (ja) * 2002-09-13 2004-04-08 Freunt Ind Co Ltd 口腔内即溶シームレスカプセルの製造方法
WO2014170947A1 (fr) * 2013-04-15 2014-10-23 三生医薬株式会社 Capsule pouvant être écrasée, procédé de fabrication pour celle-ci et accessoire à fumer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5933018B2 (ja) * 1980-03-17 1984-08-13 森下仁丹株式会社 高融点物質のマイクロカプセル製造方法とその製造装置
JP2001000509A (ja) * 1999-06-25 2001-01-09 Kao Corp カプセル粒子の製造方法
JP4217029B2 (ja) * 2002-05-13 2009-01-28 森下仁丹株式会社 シームレスカプセル

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4422985A (en) * 1982-09-24 1983-12-27 Morishita Jintan Co., Ltd. Method and apparatus for encapsulation of a liquid or meltable solid material
JPH11509768A (ja) * 1995-03-29 1999-08-31 ワーナー−ランバート・カンパニー 継ぎ目なしカプセル
JP2004105282A (ja) * 2002-09-13 2004-04-08 Freunt Ind Co Ltd 口腔内即溶シームレスカプセルの製造方法
WO2014170947A1 (fr) * 2013-04-15 2014-10-23 三生医薬株式会社 Capsule pouvant être écrasée, procédé de fabrication pour celle-ci et accessoire à fumer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021528043A (ja) * 2018-12-04 2021-10-21 ケーティー・アンド・ジー・コーポレーション 三重カプセル及びそれを製造する装置及び方法
JP7323253B2 (ja) 2018-12-04 2023-08-08 ケーティー アンド ジー コーポレイション 三重カプセル及びそれを製造する装置及び方法

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