WO2018190367A1 - 薬液注入装置 - Google Patents

薬液注入装置 Download PDF

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Publication number
WO2018190367A1
WO2018190367A1 PCT/JP2018/015205 JP2018015205W WO2018190367A1 WO 2018190367 A1 WO2018190367 A1 WO 2018190367A1 JP 2018015205 W JP2018015205 W JP 2018015205W WO 2018190367 A1 WO2018190367 A1 WO 2018190367A1
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WIPO (PCT)
Prior art keywords
injection
chemical
chemical solution
mixing ratio
control unit
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PCT/JP2018/015205
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English (en)
French (fr)
Japanese (ja)
Inventor
根本　茂
齋藤　剛
Original Assignee
株式会社根本杏林堂
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Publication date
Application filed by 株式会社根本杏林堂 filed Critical 株式会社根本杏林堂
Priority to JP2019512548A priority Critical patent/JP7028472B2/ja
Priority to US16/603,543 priority patent/US12186524B2/en
Priority to CN201880038643.1A priority patent/CN110753562B/zh
Publication of WO2018190367A1 publication Critical patent/WO2018190367A1/ja
Priority to JP2022018433A priority patent/JP2022065048A/ja

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    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
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Definitions

  • the present invention relates to a chemical liquid injector for injecting a chemical liquid filled in a container such as a syringe.
  • CT Computer Tomography
  • MRI Magnetic Resonance Imaging
  • PET PET
  • ultrasound diagnostic devices angiographic devices
  • angiography angiography
  • a chemical solution such as a contrast medium or physiological saline may be injected into a patient using the chemical solution injection device.
  • treatment techniques using an image diagnostic device can be developed only from previous image diagnosis by developing X-ray equipment, catheters, contrast agents, and the like.
  • IVR Interventional Radiology
  • an image diagnostic device can be developed only from previous image diagnosis by developing X-ray equipment, catheters, contrast agents, and the like.
  • Considering the procedure it can be divided into local injection (arterial injection) of a drug solution using a catheter, embolization of a blood vessel, expansion and opening of a blood vessel.
  • Subjects include tumors, bleeding, vascular lesions and the like.
  • TAE Transcatheter Arterial Embolization
  • For bleeding there are continuous arterial infusion of vasoconstrictors and arterial embolization, and for vascular lesions, there are thrombolysis and percutaneous angioplasty (PTA: Percutaneous Transluminal Angioplasty).
  • PTCA Percutaneous transluminal coronary angioplasty
  • PTCA Percutaneous Transaneous Coronary Angioplasty
  • atherectomy It can be roughly divided into intracoronary resection (surgery) and stent implantation.
  • various blood vessels directly connected to organs and lesions in the head, chest (including the heart), abdomen, and lower limbs are selectively or repeatedly imaged the same blood vessels (complexity).
  • change the imaging angle to know the anteroposterior relationship of the blood vessels, finely adjust the injection conditions so that the catheter can not be removed, and confirm it after treatment). Is required.
  • an angiographic apparatus that can acquire a tomographic image similar to a CT apparatus has been put into practical use.
  • a desired image can be captured only by the angiographic device. Combined testing and treatment are expected to increase further in the future.
  • the contrast agent concentration and the injection speed are appropriately adjusted according to the blood vessel site, and the contrast agent is repeatedly injected. This is one difference from the CT inspection and MR inspection.
  • Patent Document 1 discloses an example of a chemical solution injection device for angiography.
  • This chemical solution injection device is used for angiography by a catheter method, for example.
  • a catheter is percutaneously introduced into a blood vessel (artery) by a guide wire without incising the skin.
  • the drug solution injection device is operated to inject a contrast medium using a predetermined injection protocol, and continuous imaging is performed using the imaging device.
  • an image representing the contrasted blood vessel is displayed on a predetermined display, and the doctor performs diagnosis and treatment while viewing the image.
  • a device including an injection head and a console is known as a chemical solution injection device for angiography.
  • the injection head for angiography has the following characteristics that are different from the injection head for CT examination and MR examination. That is, the angiography has a feature that the injection pressure becomes very high because the drug solution is injected through an elongated catheter introduced into the blood vessel. Therefore, many syringes are configured to be attached to the injection head in a state where the syringe is put in a protective cover or the like. This is different from an injection head for CT inspection or MR inspection in which a syringe is directly attached or attached via an adapter that holds a part of the syringe.
  • Patent Document 2 discloses an angiographic drug solution injection device that can be equipped with two syringes and can simultaneously inject a contrast medium and physiological saline. According to the chemical injection device described in Patent Document 2, since the contrast medium can be diluted and injected with physiological saline, it is easy to change the concentration of the contrast medium according to the blood vessel site without replacing the syringe. Can be done.
  • Patent Document 1 International Publication No. 2006/068171
  • Patent Document 2 International Publication No. 2016/208611
  • the object of the present invention is to provide a chemical solution injection device capable of easily setting various injection conditions according to the part to be imaged and the purpose.
  • a chemical liquid injector for injecting a chemical liquid filled in a container, A first drive mechanism configured to cause the chemical liquid to flow out of the first container filled with the first chemical liquid; A second drive mechanism configured to cause the chemical liquid to flow out of the second container filled with the second chemical liquid; At least one data input interface for accepting data input; An injection controller configured to control at least operations of the first drive mechanism and the second drive mechanism; Have In the injection control unit, as one of at least one injection mode of the drug solution, at least a multi-stage injection mode for executing a series of injection operations in a plurality of injection phases is set.
  • the injection control unit receives an input of a mixing ratio of the first chemical solution and the second chemical solution for each of the plurality of injection phases through the data input interface, and receives the input.
  • the injection conditions of the first chemical liquid and the second chemical liquid are set so that the first chemical liquid and the second chemical liquid are injected at a mixing ratio, and the first drive mechanism and the first driving mechanism according to the set injection conditions.
  • a chemical liquid injector configured to control the operation of the second drive mechanism.
  • the chemical injection device of any of the present invention A first container and a second container that are detachably attached to the chemical liquid injector; An injection circuit connected to the first container and the second container; A medicinal solution injection system is provided.
  • any one of the above-described drug solution injection systems of the present invention A fluoroscopic imaging device for obtaining a medical image from a subject into which a chemical solution has been injected by the chemical solution injection system; A fluoroscopic imaging system is provided.
  • a first drive mechanism configured to cause the chemical solution to flow out of the first container filled with the first chemical solution
  • a first drive mechanism filled with the second chemical solution a second drive mechanism configured to cause the chemical solution to flow out of two containers
  • an injection control unit configured to control at least the operations of the first drive mechanism and the second drive mechanism
  • the injection control unit is an operation method of a chemical injection device in which a multi-stage injection mode in which at least a series of injection operations are executed in a plurality of injection phases is set as one of at least one injection mode of the chemical.
  • the injection control unit receiving an input of a mixing ratio of the first chemical solution and the second chemical solution for each of the plurality of injection phases in the multistage injection mode; Setting the injection conditions of the first chemical solution and the second chemical solution so that the injection control unit injects the first chemical solution and the second chemical solution at the received mixing ratio;
  • the injection control unit controlling operations of the first drive mechanism and the second drive mechanism according to the set injection conditions;
  • injection circuit means a path for circulating a drug solution connected to a container such as a syringe for injection of the drug solution into the blood vessel of the subject, and is a catheter or a subject inserted into the blood vessel of the subject An indwelling needle to be pierced into the blood vessel.
  • the injection circuit further includes an extension tube branched into a plurality of ends connected to the container, and the distal end of the extension tube is connected to the catheter or the indwelling needle.
  • at least one member such as another tube may be connected between the extension tube and the catheter or indwelling needle.
  • the injection circuit can be divided into an “extracorporeal circuit portion” that is all located outside the body and an “internal circuit portion” that is at least partially located inside the body, depending on the arrangement in use.
  • the catheter or the indwelling needle belongs to an in-vivo circuit
  • a member such as the extension tube that connects the portion of the in-vivo circuit portion located outside the body and the container belongs to the extra-corporeal circuit portion.
  • “Purge operation” means an operation of releasing a chemical solution from a container in order to fill the extracorporeal circuit portion of the injection circuit with a desired chemical solution prior to the injection of the chemical solution to a subject. When it also serves the purpose of discharging air in the container and / or the extracorporeal circuit, it may be referred to as “air bleeding”. In this purge operation, no chemical solution is injected into the subject's body.
  • the present invention it is possible to input the mixing ratio of the first chemical solution and the second chemical solution for each of the first phase and the second phase, so that each injection phase depends on the region to be imaged and the purpose.
  • Various injections in which the mixing ratio of the chemical solution is changed can be set in a single injection mode.
  • FIG. 1 is a schematic block diagram of a fluoroscopic imaging system according to an embodiment of the present invention. It is a perspective view which shows an example of the external appearance of the chemical injection device by one Embodiment of this invention. It is a perspective view which shows the injection
  • FIG. 9A shows the other example of the chemical
  • FIG. 9A shows an example of the dilution rate input screen which can be used when setting a dilution rate as an example of a mixing ratio.
  • FIG. 9A shows typically the other form of the extension tube connected to a syringe.
  • FIG. 9A shows typically the other form of the extension tube connected to a syringe.
  • FIG. 9A shows sectional drawing of the mixing device with which the extension tube shown to FIG. 9A is equipped.
  • FIG. 1 there is shown a block diagram of a fluoroscopic imaging system according to an embodiment of the present invention having a chemical injection device 100 and a fluoroscopic imaging device 500.
  • the chemical injection device 100 and the fluoroscopic imaging device 500 can be connected to each other so that data can be transmitted and received between them.
  • the connection between the two can be a wired connection or a wireless connection.
  • the fluoroscopic imaging device 500 is an angio device
  • the chemical solution injection device 100 is an injection device for an angio test suitable for injecting at least a contrast medium as a chemical solution in an angio test. An example will be described.
  • the fluoroscopic imaging apparatus is an arbitrary fluoroscopic imaging apparatus such as an X-ray CT apparatus, an MRI apparatus, and a PET apparatus as long as it constitutes a system capable of performing an inspection using a plurality of types of chemical solutions.
  • the chemical solution injection device may be any injection device compatible with the fluoroscopic imaging device. Therefore, the configuration described in detail below can be appropriately changed according to the types of the fluoroscopic imaging device and the chemical liquid injector.
  • the fluoroscopic imaging device 500 includes an imaging operation unit 520 that performs an imaging operation, and an imaging control unit 510 that controls the operation of the imaging operation unit 520.
  • a medical image including a tomographic image and / or a 3D image can be acquired.
  • the imaging operation unit 520 includes a subject bed, an electromagnetic wave irradiation unit that irradiates electromagnetic waves to a predetermined space on the bed, and the like.
  • the imaging control unit 510 controls the operation of the entire fluoroscopic imaging apparatus, such as determining imaging conditions and controlling the operation of the imaging operation unit 520 according to the determined imaging conditions.
  • the imaging control unit 510 can be configured by a so-called microcomputer, and can have an interface with a CPU, ROM, RAM, and other devices.
  • a computer program for controlling the fluoroscopic imaging apparatus 500 is installed in the ROM.
  • the CPU controls the operation of each part of the fluoroscopic imaging apparatus 500 by executing various functions corresponding to this computer program.
  • the fluoroscopic imaging apparatus 500 may further include a display unit 504 such as a liquid crystal display capable of displaying imaging conditions and acquired medical images, and an input unit 503 such as a keyboard and / or mouse for inputting imaging conditions and the like. it can. Data input from the input unit 503 is transmitted to the imaging control unit 510, and data displayed on the display unit 504 is transmitted from the imaging control unit 510.
  • a touch panel in which a touch screen is arranged as an input unit on the display unit display can also be used as the input unit 503 and the display unit 504.
  • the drug solution injection device 100 is a device used to inject a drug solution filled in a syringe as a container into a blood vessel of a subject via an injection circuit, and includes a plurality of piston drive mechanisms 130a and 130b, and an input unit. 103, a display unit 104, and an injection control unit 101.
  • the piston drive mechanisms 130a and 130b are mechanisms for operating the piston of the syringe so as to release the chemical solution from the syringe. In this embodiment, the two syringes can be injected separately or simultaneously.
  • Two piston drive mechanisms 130a and 130b for independently operating the pistons are provided. However, there may be a plurality of at least one of the piston driving mechanism 130a for injecting one chemical liquid and the piston driving mechanism 130b for injecting the other chemical liquid.
  • the injection control unit 101 determines the injection conditions such as the injection amount and the injection speed of the chemical liquid, controls the operation of the piston drive mechanisms 130a and 130b so that the chemical liquid is injected from the syringe according to the determined injection conditions,
  • the overall operation of the chemical injection device is controlled by controlling the display of the unit 104 or the like.
  • the injection control unit 101 can be constituted by a so-called microcomputer, and can have an interface with a CPU, ROM, RAM, and other devices.
  • a computer program for controlling the chemical injection device 100 is mounted in the ROM.
  • the CPU can control the operation of each part of the chemical solution injector 100 by executing various functions in response to the computer program.
  • the input unit 103 is a unit that receives input of data necessary for the injection control unit 101 to determine the injection condition of the chemical solution and other data.
  • the input unit 103 may be a known input device such as a keyboard and / or a mouse. Data input from the input unit 103 is transmitted to the injection control unit 101 and received by the injection control unit 101.
  • the display unit 104 receives data from the injection control unit 101 and is controlled by the injection control unit 101 to display data necessary for determining the injection condition of the chemical solution, display of the injection protocol, display of the injection operation, A warning is displayed.
  • the display unit 104 may be a known display device such as a liquid crystal display device. Further, a touch screen functioning as a data input interface and a display unit can be used as the input unit 103 and the display unit 104 by arranging a touch screen as an input unit on the display of the display unit.
  • FIG. 2 is an example of the chemical liquid injector 100 shown in FIG.
  • An injection device for an angio device (angiography device) is shown, and has an injection head 110, a console 112, and a main unit 114.
  • the injection head 110 and the console 112 are electrically connected via the main unit 114.
  • the injection head 110 is supported by the upper part of the stand 116 so as to be able to turn, but may be supported by a turning arm fixed to the ceiling.
  • the console 112 can include the input unit 103 and the display unit 104 described above.
  • the console 112 includes a touch panel, which corresponds to the input unit 103 and the display unit 104 described above.
  • the main unit 114 can include a power supply (not shown) and can supply power to the injection head 110 and the console 112 from this power supply.
  • the injection control unit 101 illustrated in FIG. 1 may be disposed in the main unit 114 or may be disposed in the console 112.
  • the injection head 110 is configured so that two sets of syringe assemblies 200 can be detachably mounted (in FIG. 3, only one set of syringe assemblies 200 is shown for simplicity). )
  • the syringe assembly 200 includes a syringe 220 and a protective cover 270 into which the syringe 220 is inserted.
  • the syringe 220 is generally called a rodless syringe, and includes a cylinder 221 having a flange 221a formed at the end and a nozzle portion 221b formed at the tip, and a piston 222 inserted into the cylinder 221 so as to be able to move forward and backward. have.
  • an extension tube 300 as shown in FIG. 4 that constitutes the extracorporeal circuit portion of the injection circuit can be connected to the tip of each syringe 220.
  • the extension tube 300 has a first tube 301, a second tube 302, a third tube 303, and a T-shaped connector 304 for connecting them, and as a whole takes the form of a branch tube branched at the end side. ing.
  • the first tube 301 and the second tube 302 have connectors 305 and 306 at their ends for connection with the nozzle portion 211b of the syringe 220, respectively.
  • the third tube 303 has a connector 307 for connection with a catheter or the like at the tip thereof.
  • At least one of the connectors 305 and 306 connected to the first tube 301 and the second tube 302 may include a one-way valve.
  • the valve has a valve body that is actuated by the back pressure of the fluid to close the flow path, and the syringe 220 is connected from the distal end side of the extension tube 300, that is, the side to which the catheter or the like is connected. It works to prevent back flow of fluid to the side.
  • at least one of the one valves may have a release function that can arbitrarily hold the valve body at the open position of the flow path by a predetermined operation.
  • valve since the valve has a release function, it is possible to prevent blood from flowing back to the syringe 220 side normally, but blood is used to confirm whether the tip of the catheter or the like is normally located in the blood vessel of the subject. A so-called route check or the like can be performed.
  • the end of the internal circuit portion such as a catheter inserted into the blood vessel of the subject is connected to the third tube 303, so that Can be injected.
  • the chemical solution filled in the syringe 220 for example, the syringe 220 connected to the first tube 301 is filled with a contrast agent, and the syringe 220 connected to the second tube 302 is filled physiologically. It can be a saline solution. Alternatively, a syringe 220 filled with contrast agents having different concentrations may be connected to the first tube 301 and the second tube 302, respectively.
  • Contrast agents used for imaging medical images have a relatively high viscosity, and in particular, contrast agents used for imaging an angio apparatus tend to be higher in viscosity than other types of contrast agents.
  • the catheter is generally very thin with an inner diameter of less than 2 mm. Therefore, when the contrast medium is filled in the syringe 220 as a chemical solution and the piston 222 is advanced to inject the contrast medium, a very high internal pressure is generated in the cylinder 221. This high internal pressure may cause the cylinder 221 to expand and cause various troubles in contrast agent injection.
  • the protective cover 270 suppresses expansion and breakage due to an increase in the internal pressure of the cylinder 221 at the time of injecting the chemical solution, and is dimensioned so that there is almost no gap between the outer periphery of the cylinder 221 when the cylinder 221 is inserted. It is a cylindrical member.
  • the protective cover 270 is preferably formed with a thickness having a mechanical strength that can sufficiently withstand the internal pressure acting on the cylinder 221 during the injection of the chemical liquid.
  • An opening through which the nozzle part 221b of the syringe 220 passes is formed at the tip of the protective cover 270, and the syringe 220 is held in a state where the nozzle part 221b protrudes from the opening.
  • a cover flange 271 is formed at the end of the protective cover 270 in which a ring-shaped recess for receiving the flange 221a of the cylinder 221 is formed on the end surface.
  • the injection head 110 has first and second piston drive mechanisms 130a and 130b (see FIG. 1) that are driven independently of each other to advance and retract the pistons 222 of the two sets of syringe assemblies 200 mounted.
  • the syringe assemblies 200 are arranged corresponding to the positions where they are mounted.
  • Each of the piston drive mechanisms 130a and 130b includes a presser 131 that holds a convex portion formed at the end of the piston 222, a drive source such as a motor that moves the presser 131 forward and backward, and a power transmission mechanism that connects them.
  • the syringe assembly 200 attached to the injection head 110 can inject the medical solution filled in the syringe 220 into the subject separately or simultaneously by the piston 222 being advanced by the piston drive mechanisms 130a and 130b. it can.
  • the piston drive mechanism 130 a known mechanism generally used in this type of injection device can be employed.
  • the tip of the injection head 110 is provided with a syringe receiver 120 and a clamper 140 that constitute a syringe mounting portion on which the syringe assembly 200 is placed.
  • the syringe receiver 120 is located on the tip side of the clamper 140 and has two recesses 121 so as to receive the outer peripheral surface of each syringe assembly 200 individually.
  • the clamper 140 is supported so as to be openable and closable with respect to the syringe receiver 120, and is configured to individually hold the cover flange 271 of the protective cover 270 of each syringe assembly 200.
  • Each syringe assembly 200 is positioned in the recess 121 with the nozzle portion 221b facing the distal end side, and the syringe assembly 200 is fixed to the injection head 110 by closing the clamper 140.
  • the protective cover 270 is not an essential component, and the syringe 220 may be directly attached to the injection head 110. That is, the present invention includes both those in which the syringe 220 is directly attached to the injection head 110 and those in which the syringe 220 is indirectly attached via another member.
  • the injection head 110 can have an exterior cover 125 that covers the entire mechanism except for the portion having the syringe receiver 120 and the clamper 140.
  • the exterior cover 125 can have a mark 125 a for distinguishing the corresponding presser 131 at a position corresponding to each presser 131.
  • the sign 125a may be any character or symbol, and in this embodiment, the characters “A” and “B” are used. This marker can also be used to distinguish the syringe 220 (medical solution) on an injection condition setting screen 400 (see FIG. 5) described later.
  • the chemical solutions filled in the syringes 220 attached to the syringe receiver 120 corresponding to the label 125a may be referred to as “medical solution A” and “chemical solution B”.
  • the chemical injection device 100 may further include a hand switch 118 and / or a foot switch 119 as an option.
  • the hand switch 118 has an operation button, and is used to control the start and stop of the injection operation so that the injection operation of the chemical solution by the injection head 110 is performed only while the operation button is pressed. it can.
  • the foot switch 119 is used to control the start and stop of the injection operation so that the injection operation of the chemical solution by the injection head 110 is performed only while the foot switch 119 is stepped on, for example, when performing test injection. Can do.
  • Test injection is performed as necessary prior to imaging for acquiring a medical image, for example, to grasp individual differences in contrast effects and / or to confirm the tip position of an injection circuit. It is the injection of chemicals.
  • the injection of a medical solution for acquiring a medical image may be referred to as “main injection” for the purpose of distinction from the test injection.
  • main injection a smaller amount of chemical solution is usually injected than in the main injection.
  • the injection rate of the chemical solution in the test injection is usually set in advance or set to be the same as the injection rate of the chemical solution in the main injection. This test injection can also be performed by operating the hand switch 118.
  • the hand switch 118 is operated at the stage where the setting of the injection protocol for the chemical solution is completed and the preparation for injection is completed (standby state), the main injection is executed, but the hand switch 118 is operated at the previous stage. If so, a test injection can be performed.
  • the power of the chemical injection device 100 is turned on by the operator. Thereafter, the syringe assembly 200 filled with a chemical to be poured into the subject is attached to the injection head 110.
  • a chemical solution container (not shown) is connected to the nozzle portion 221b via an appropriate tube, and in this state, the piston drive mechanism
  • the syringe assembly 200 filled with the chemical solution may be mounted on the injection head 110 by retracting the piston 222 and filling the syringe assembly 200 with the chemical solution.
  • the former filled with the chemical solution by the manufacturer is called a prefilled type, and the latter is filled with the chemical solution at the medical site. This is also called a post-filling type.
  • the mounting of the syringe assembly 200 to the injection head 110 can be performed, for example, by the following procedure.
  • the operator closes the clamper 140, whereby the syringe assembly 200 is held by the injection head 110.
  • the injection head 110 preferably has a lock mechanism (not shown) that locks the clamper 140 so that it can be opened in the closed position.
  • the lock mechanism may be any mechanism as long as it can lock and release the clamper 140 in the closed position. By having the locking mechanism, it is possible to prevent the syringe assembly 200 attached to the injection head 110 from being detached from the injection head 110.
  • the injection head 110 preferably includes at least one detector that detects that the syringe assembly 200 is attached to the injection head 110.
  • a first detector that detects that the syringe assembly 200 is placed on the syringe receiving recess 121 and that the clamper 140 is in the closed position are detected.
  • the first detector for example, a detector that is arranged in the syringe receiving recess 121 and can detect the syringe assembly 200 in the syringe receiving recess 121 can be used.
  • the second detector for example, a detector that is built in the injection head 110 and can detect the tip of the clamper 140 when the clamper 140 is in the closed position can be used.
  • any of these detectors can detect an object to be detected when the distance between the object to be detected such as the syringe assembly 200 or the clamper 140 is less than a predetermined distance (including contact).
  • an optical sensor that optically detects the presence or absence of an object in a detection region
  • a proximity sensor that detects the presence or absence and position of an object using magnetism as a detection medium
  • a contact with an object to be detected A mechanical switch that is switched on / off by non-contact can be used.
  • the mechanical switch any switch including, for example, a tact switch and a limit switch can be used as long as it is switched on / off by contact / non-contact of the object to be detected.
  • the injection head 110 does not need to include both the first detector and the second detector in order to detect that the syringe assembly 200 is attached to the injection head 110, but only one of them. It may be.
  • the injection control unit 101 displays information indicating that the mounting of the syringe assembly 200 is completed on the display unit 104. It is possible to display it and visually notify the operator, or to move the operation of the chemical injection device 100 to the next step.
  • the information displayed on the display unit 104 may be a message by text or information represented by a symbol.
  • a light emitting lamp (not shown) is provided separately from the display unit 104, and the injection control unit 101 turns on the light emitting lamp to visually notify the operator that the mounting of the syringe assembly 200 is completed. it can.
  • the light emitting lamp can be provided in the injection head 110.
  • the position of the light-emitting lamp provided in the injection head 110 may be arbitrary, but is preferably in the vicinity of the part that is last operated by the operator when the syringe assembly 200 is mounted, for example, in the vicinity of the clamper 140. In particular, as shown in FIG.
  • an indicator 125a (specifically, letters “A” and “B”) is provided to allow the two piston drive mechanisms 130a and 130b to be identified. It is preferable to arrange two light-emitting lamps so that these label portions each emit light as a light-emitting portion.
  • the color visually recognized by the lighting of the light-emitting lamp may be arbitrary, and may be a different color for each corresponding chemical solution, for example, blue and green.
  • the injection head 110 can also include a light emitting unit 126 that emits light by turning on another light emitting lamp that emits light in the standby state described above. In the form shown in FIG. 3, the light emitting units 126 are arranged at positions distant from each other, but by doing so, it is possible to visually recognize that they are in the standby state from any direction.
  • the injection control unit 101 executes an operation for injecting the chemical solution.
  • This operation can include, for example, the following series of steps. (1) Reception of data input and setting of injection conditions (2) Execution of injection operation according to the set injection conditions (3) Injection operation end processing These processes will be described below in order.
  • the injection control unit 101 causes the display unit 104 to display a screen for setting injection conditions, and inputs to the input unit 103 for setting injection conditions. Accept.
  • the injection control unit 101 can display an injection condition setting screen 400 including an icon for receiving data input on the touch panel.
  • FIG. 5 shows an example of the injection condition setting screen 400.
  • FIG. 5 shows an injection condition setting screen 400 in a two-stage injection mode that is one of one or a plurality of injection modes set in the injection control unit 101, and an injection mode icon 401, A confirmation icon 403, speed setting icons 404a and 404b, injection amount setting icons 405a and 405b, chemical solution mixing ratio setting icons 407a and 407b, syringe information icons 408a and 408b, injection pressure limit value setting icons 409, and the like can be included.
  • syringe information icons 408a and 408b information about the respective syringes 220 for the chemical solution A and the chemical solution B mounted on the injection head 110 (see FIG. 3) is displayed in a graphic form.
  • the information displayed on the syringe information icons 408a and 408b can include the amount of the chemical solution filled in the attached syringe 220.
  • the chemical liquid injection operation can be visually recognized by an arbitrary animation display in the injection condition setting screen 400 or on another screen.
  • the injection mode icon 401 is an icon representing in which injection mode the injection operation is to be executed among one or a plurality of injection modes set in the injection control unit 101.
  • As the injection mode for example, “normal injection mode” in which injection with only the chemical liquid A is performed, “flash mode” in which the chemical liquid B is injected after the injection of the chemical liquid A is completed, and “multiple” in which only the chemical liquid A is injected in multiple phases “Mode”, “two-stage injection mode” in which the chemical liquid A and the chemical liquid B are mixed at an arbitrary ratio and the second phase is executed after the first phase.
  • FIG. 5 shows a state where the “two-stage injection mode” is selected.
  • the injection control unit 101 switches the display of the injection mode icon 401, thereby switching the injection mode.
  • the display of the injection mode icon 401 in which “two-stage injection mode” is selected is “two-stage dilution”, but the display allows the user to clearly recognize that it is “two-stage injection mode”. If there is, it is not limited to this.
  • injection mode set in the injection control unit 101 may be set in advance, or may be additionally set later by implementation of a program or the like.
  • the confirmation icon 403 is operated when the operator approves the injection condition displayed on the injection condition setting screen 400.
  • the injection control unit 101 moves the chemical injection device 100. It is possible to shift to the next step of the chemical solution injection procedure by setting the standby state.
  • the injection pressure limit value setting icon 409 is an icon used for setting and inputting the injection pressure limit value of the chemical solution in the first phase and the second phase.
  • the selected injection pressure limit value is set in the injection control unit 101.
  • the injection control unit 101 controls the operation of the piston drive mechanisms 130a and 130b so as not to exceed the set injection pressure limit value. The detection of the injection pressure will be described later.
  • the speed setting icons 404a and 404b and the injection amount setting icons 405a and 405b are used for setting and inputting the injection speed and the injection amount of the chemical liquid A and the chemical liquid B for the first phase and the second phase, respectively.
  • the upper speed setting icon 404a and the injection amount setting icon 405a are the icons for the first phase
  • the lower speed setting icon 404b and the injection amount setting icon 405b are the first icons. This is an icon for two phases.
  • the setting of the injection rate and the injection amount can be performed as follows. For example, when setting the injection speed, when the operator taps the speed setting icons 404 a and 403 b, the injection control unit 101 overshoots the injection speed input numeric keypad icon (not shown) on the injection condition setting screen 400. Display lap display. The operator can set the injection rate by inputting and confirming a numerical value through the numeric keypad screen. The injection amount can also be set in the same manner as the setting of the injection rate.
  • the numeric keypad icon may be the same as the numeric keypad icon 431 (see FIG. 6) on the ratio setting screen 430 described later, for example.
  • the speed setting icons 404a and 404b and the injection amount setting icons 405a and 405b set the total injection speed and the injection amount of the drug solution A and the drug solution B.
  • the speed setting icons 404a and 404b and the injection amount setting icons 405a and 405b are mixing ratios set by the chemical liquid mixture ratio setting icons 407a and 407b in addition to the total injection speed and injection amount of the chemical liquid A and the chemical liquid B, respectively.
  • the injection speed of the drug solution A and the injection speed and the injection speed of the injection volume drug solution B can be displayed.
  • Chemical solution mixing ratio setting icons 407a and 407b are icons used for setting and inputting the mixing ratio of the chemical liquid A and the chemical liquid B of the chemical liquid injected in each of the first phase and the second phase.
  • the mixing ratio of the chemical solution There are several ways to express the mixing ratio of the chemical solution.
  • the amount of the chemical solution A relative to the total amount of the chemical solution A and the chemical solution B that is, the amount of the chemical solution A / (the amount of the chemical solution A + the chemical solution B It is expressed by the mixing ratio calculated by (amount).
  • the mixing ratio may be set to 50% as a default value.
  • the mixing ratio can be set within a range of 0% to 100%.
  • the mixing ratio is 0%, only the chemical liquid A is injected, and when the mixing ratio is 100%, only the chemical liquid B is injected.
  • the upper liquid chemical mixture ratio setting icon 407a is a first phase icon
  • the lower liquid chemical mixture ratio setting icon 407b is a second phase icon.
  • the mixing ratio means how much physiological saline is contained with respect to the total amount.
  • the setting of the mixing ratio can be performed as follows, for example.
  • the injection control unit 101 displays a mixture ratio input screen which is a form of the mixture ratio input screen as shown in FIG. 6 on the injection condition setting screen 400.
  • 430 is displayed as a pop-up, or the display is switched from the injection condition setting screen 400 to the mixing ratio input screen 430.
  • the mixing ratio input screen 430 can include a numeric keypad icon 431 and a ratio setting bar 432. With the numeric keypad icon 431, the ratio of the amount of the chemical solution A to the total amount of the chemical solution A and the chemical solution B can be set numerically.
  • the injection control unit 101 determines the input numerical value as a mixing ratio.
  • the ratio setting bar 432 may have a ratio display part 432a and a slider icon 432b.
  • the ratio display unit 432a indicates the ratio between the chemical solution A and the chemical solution B as a band graph, and the slider icon 432b is displayed at a display position so that the slider icon 432b can be moved along the ratio display unit 432a while being touched by the operator. Is controlled.
  • the injection control unit 101 sets the mixing ratio to a ratio corresponding to the position of the slider icon 432b.
  • the ratio display unit 432a may display the drug solution A side and the drug solution B side in different colors with respect to the position of the slider icon 432b.
  • the mixing ratio can be set from either the numeric keypad icon 431 or the ratio bar 432. Further, the mixture ratio input screen 430 may have only one of the numeric keypad icon 431 and the ratio bar 432. Furthermore, the input of the mixing ratio is not limited to the above method, and any method can be used.
  • the injection control unit 101 deletes the pop-up display of the mixing ratio input screen 430 from the injection condition setting screen 400 or the injection condition setting screen according to the display form of the mixing ratio input screen 430.
  • the display is switched to 400, and the set mixing ratio is displayed on the mixing ratio icons 407a and 407b of the injection condition setting screen 400.
  • the speed setting icons 404a and 404b and the injection amount setting icons 405a and 405b include the display of the respective injection speeds and injection amounts of the chemical liquid A and the chemical liquid B, these displays also follow the set mixing ratio. It is changed to the value of the injection rate and the injection amount.
  • the injection condition setting screen 400 may have an injection pattern display unit 410.
  • the injection pattern display unit 410 displays the injection pattern of the chemical liquid to be injected according to the mixing ratio of the chemical liquid A and the chemical liquid B set in the first phase and the second phase.
  • the display form of the injection pattern on the injection pattern display unit 410 is arbitrary. In the example shown in FIG. 5, the upper part of the arrow represents the injection in the first phase, and the lower part represents the injection in the second phase.
  • a + B means that the chemical solution A and the chemical solution B are injected at the same time.
  • injection patterns Examples of injection patterns that can be set in the two-stage injection mode are shown below.
  • Injection pattern (c) “A + B ⁇ A” when the mixing ratio of the chemical liquid B is set to 0 in the first phase and the mixing ratio of the chemical liquid A and the chemical liquid B is set to other than 0 in the second phase.
  • the injection pattern as described above can be appropriately used depending on the imaging region, the imaging purpose, and the like.
  • the effectiveness of some injection patterns when the drug solution A is a contrast medium and the drug solution B is physiological saline will be described.
  • a contrast medium that is not diluted is injected in the first phase, and a low-concentration contrast medium diluted with physiological saline is injected in the second phase thereafter.
  • the blood vessel into which the contrast medium is injected has a higher contrast effect in the portion injected in the first phase than in the portion injected in the second phase.
  • Such an injection pattern is suitable for imaging a blood vessel image when, for example, hepatic arteriography, the tip side is thin and difficult to depict.
  • the concentration of the contrast medium injected in the second phase lower than the concentration of the contrast medium injected in the first phase, there is a high concentration of contrast medium on the tip side that is difficult to be visualized, and artifacts are generated. Since a low-concentration contrast medium exists on the root side that tends to be large, as a result, a good blood vessel image can be drawn from the root side to the tip side.
  • a contrast medium diluted with physiological saline is injected in the first phase, and a contrast medium that is not diluted is injected in the second phase.
  • the blood vessel into which the contrast medium is injected has a higher contrast effect in the portion injected in the second phase than in the portion injected in the first phase.
  • Such an injection pattern is suitable for imaging a blood vessel image when it is desired to distinguish between an artery and a vein in order to know the malformed site in a cerebral artery malformation examination, for example.
  • the concentration of the contrast agent injected in the first phase lower than the concentration of the contrast agent injected in the second phase, when most of the contrast agent injected in the first phase reaches the vein, Most of the contrast medium injected in the two phases will be present in the veins.
  • the arteries and veins are distinguished by the difference in the contrast of the blood vessel image caused by the difference in contrast agent concentration between the arteries and veins. It becomes possible to do.
  • physiological saline is injected in the first phase, and undiluted or diluted contrast agent is injected in the second phase.
  • the injection amount of the drug solution B injected in the first phase in the injection pattern (e) is preferably an amount at which at least the extracorporeal circuit part and the in-vivo circuit part are filled with the drug solution B, for example, 3 to 6 ml.
  • the contrast agent is injected in a state where the portion of the blood vessel downstream from the injection circuit is filled with the physiological saline.
  • the following effects can be obtained.
  • a subtraction process may be performed.
  • the subtraction process only the blood vessel image is extracted by the differential processing between the plain image data obtained by imaging before injecting the contrast agent and the contrast image data obtained by imaging after injecting the contrast agent. Blood vessel image data is obtained.
  • the blood vessel position is deviated between the plane image data and the contrast image data, accurate blood vessel image data cannot be obtained. It is considered that the displacement of the blood vessel is affected by the flow state of the liquid (blood, contrast medium, physiological saline, etc.) inside the blood vessel.
  • imaging is performed to obtain plain image data while the physiological saline injected in the first phase flows in the blood vessel, and while the contrast agent injected in the second phase flows in the blood vessel. Imaging is performed to obtain contrast image data.
  • plane image data and contrast image data under almost common conditions in which both liquids flow in the blood vessel.
  • the displacement of the blood vessel between these two image data is suppressed, and better blood vessel image data can be obtained.
  • the injection pattern (e) is considered to be effective in the subtraction process.
  • an injection pattern is not restricted to what was mentioned above, You may enable it to set various injection patterns as needed.
  • the operator performs a data input operation as necessary according to the display of the injection condition setting screen 400.
  • the display is switched to “start OK”, and the chemical injection device 100 is in a standby state in which chemical injection is possible. Become.
  • the injection operation of the chemical liquid is performed by the injection control unit 101 controlling the operations of the piston drive mechanisms 130a and 130b so that the chemical liquid is injected under the set injection conditions (injection speed, injection amount, injection time, etc.). Is called.
  • the injection control unit 101 controlling the operations of the piston drive mechanisms 130a and 130b so that the chemical liquid is injected under the set injection conditions (injection speed, injection amount, injection time, etc.). Is called.
  • the piston drive mechanisms 130a and 130b are operated simultaneously so that the chemical liquid A and the chemical liquid B are simultaneously injected at the set mixing ratio.
  • the fluoroscopic imaging device 500 starts an imaging operation corresponding to the chemical solution injection operation by the chemical solution injection device 100.
  • the imaging operation by the fluoroscopic imaging device 500 may be executed by using the operation of the fluoroscopic imaging device 500 by an operator as a trigger, or may be automatically executed in conjunction with the injection operation by the chemical solution injection device 100.
  • the injection operation and the imaging operation are linked, for example, after the injection operation is started, the imaging operation is started after a predetermined time required for the injected drug solution to reach the target site.
  • the injection control unit 101 of the chemical solution injection device 100 transmits an injection start signal to the imaging control unit 510 of the fluoroscopic imaging device 500, and the imaging control unit 510 that has received the injection start signal receives the imaging operation unit 520 after the predetermined time has elapsed.
  • the injection control unit 101 transmits an injection start signal to the image pickup control unit 510 after the elapse of the predetermined time after the injection operation is started, and the image pickup control unit 510 receives the injection start signal.
  • the imaging operation unit 520 can be controlled to start the imaging operation.
  • the imaging control unit 510 can reconstruct the data obtained by the imaging operation of the imaging operation unit 520 to acquire a medical image, and display the acquired medical image on the display unit 504 in real time.
  • the imaging control unit 510 displays the data in the display unit 503. Some or all of the injection conditions can be displayed in real time together with or separately from medical images and imaging conditions.
  • the cumulative up to the imaging stage The injection amount and the X-ray irradiation amount can be displayed. As a result, it is judged on the spot whether the cumulative X-ray irradiation dose does not exceed the reference value, and whether the injection amount of the contrast medium does not exceed the reference value for subjects with poor liver function, When the X-ray irradiation amount and / or the injection amount is likely to exceed the reference value, the X-ray irradiation amount and the contrast agent injection amount can be adjusted as necessary.
  • the injection control unit 101 can display the injection result on the display unit 104 as one of the injection operation end processes. Examples of displayed results include the injection end date and time, the injection mode, the set imaging site, the injection speed, the injection volume, the mixing ratio, the time required for injection, the maximum pressure during injection, etc., and are displayed. May be at least one of these items. Further, as one of the injection operation end processes, the injection control unit 101 records these injection results in an appropriate memory device inside or outside the chemical solution injection device 100 or transmits them to the fluoroscopic imaging device 500. Can do.
  • the injection control unit 101 can display the injection condition setting screen 400 on the display unit 104 again by a predetermined operation by the operator.
  • the injection conditions are set on the injection condition setting screen 400, and the chemical solution may be injected under the set injection conditions. it can.
  • the injection conditions for each injection are set in advance, it is possible to start the next injection operation without displaying the injection condition setting screen 400 every time the injection is completed.
  • the mixing ratio can also be expressed as a dilution factor.
  • the dilution ratio is the total amount of the chemical solution A and the chemical solution B with respect to the amount of the chemical solution A, that is, (the amount of the chemical solution A + the amount of the chemical solution B) / the amount of the chemical solution A, as in the above-described concept of the mixing ratio.
  • the injection condition setting screen etc. When the mixing ratio is expressed as a dilution ratio, the injection condition setting screen etc. will be changed as necessary. For example, as shown in FIG. 7A, the currently set dilution ratio is displayed on the chemical solution mixing ratio setting icon 407 displayed on the injection condition setting screen.
  • the injection control unit 101 displays, for example, a dilution ratio that is another form of the mixing ratio input screen as shown in FIG. 7B.
  • the input screen 440 is popped up on the injection condition setting screen.
  • the dilution rate input screen 440 can have at least one of a numeric keypad icon 441 and a magnification setting bar 442, as with the mixing ratio input screen 430 shown in FIG.
  • a dilution factor represented by the total amount of the chemical solution A and the chemical solution B with respect to the amount of the chemical solution A can be set as a numerical value.
  • the injection control unit 101 determines the input numerical value as a dilution factor.
  • the magnification setting bar 442 can have a magnification display portion 442a and a slider icon 442b.
  • the magnification display unit 442a can indicate the set magnification in a logarithmic graph format.
  • the display position of the slider icon 442b is controlled so that the slider icon 442b can be moved along the magnification display unit 442a while being touched by the operator.
  • the injection control unit 101 sets the dilution magnification to a magnification corresponding to the position of the slider icon 442b.
  • the chemical solution A side and the chemical solution B side may be displayed in different colors with respect to the position of the slider icon 442b.
  • FIG. 7C shows still another form of the mixing ratio input screen.
  • the mixing ratio input screen 450 shown in FIG. 7C has injection speed / injection amount displays 451a and 451b, mixing ratio displays 452a and 452b, and ratio adjustment icons 453a and 453b for each of the chemical liquid A and the chemical liquid B.
  • the ratio adjustment icons 453a and 453b are used to change the mixing ratio of the chemicals, and each time the tapping is performed, the mixing ratio display 452a and 452b of the tapping side increases by 1%, and the other mixing ratio
  • the indications 452a and 452b can be decreased by 1%.
  • a slide bar icon 454 can be provided for a case where the mixing ratio is greatly changed.
  • the slide bar icon 454 can include, for example, a ratio display unit that displays a mixing ratio of the chemical solution A and the chemical solution B on a band graph, and a slider icon displayed thereon.
  • the operator can change the display of the mixing ratio of the chemical liquid A and the chemical liquid B in units of, for example, 10% by moving to the chemical liquid A side or the chemical liquid B side while touching the slider icon.
  • the input mixing ratio is set in the injection control unit 101.
  • the container filled with the chemical solution is a syringe
  • the container is not limited to a syringe, and may be a chemical solution bottle or a chemical solution bag.
  • a drive mechanism corresponding to the form of the container such as a tube pump type drive mechanism, can be used.
  • the two-stage injection having the first injection phase and the second injection phase as the injection mode has been described as an example.
  • the injection mode may be a multistage injection mode in which a series of injection operations are executed in three or more injection phases.
  • the injection control unit 101 displays icons set for each injection phase, such as a speed setting icon, an injection amount setting icon, and a chemical solution mixing ratio setting icon, on the same injection condition setting screen, It is preferable that the injection conditions can be set on the same injection condition setting screen.
  • a purge operation can be performed prior to the injection of the chemical solution.
  • the purge operation is performed after an extracorporeal circuit portion (for example, an extension tube) of the injection circuit is connected to the syringe assembly 200 and before the chemical solution injection operation is started.
  • the fluid containing air and the chemical solution in the extracorporeal circuit unit is released from the injection circuit by the chemical solution.
  • the purge operation is performed in a state where the tip of the extracorporeal circuit unit is not connected to the end of the intracorporeal circuit unit or between the extracorporeal circuit unit and the intracorporeal circuit unit.
  • the purge operation is basically performed when the extracorporeal circuit unit is not filled with the chemical solution, so as to fill the extracorporeal circuit unit with the chemical solution, and needs to be performed when the extension tube 300 is filled with the chemical solution. There is no. However, if the mixing ratio is changed, such as when the second injection is performed at a different mixing ratio from the first injection, for example, the purge is performed even if the extracorporeal circuit unit is filled with the chemical solution. It may be preferable to perform the operation.
  • the injection head 110 can have a purge button 123 (see FIG. 3).
  • a purge icon (not shown) can be displayed on the injection condition setting screen 400 shown in FIG. Furthermore, it is possible to have both of these.
  • the injection control unit 101 executes the purge operation.
  • the operations of the piston drive mechanisms 130a and 130b can be controlled so that both the chemical liquid A and the chemical liquid B are discharged from the syringe 220 at the same speed and amount.
  • the piston drive mechanisms 130a and 130b are operated so that the chemical liquid A and the chemical liquid B are released from each syringe 220 at the set mixing ratio. Can be controlled.
  • the distal end side of the junction part of the extracorporeal circuit part for example, the T-shaped connector 304 of the extension tube 300 shown in FIG.
  • the hand switch 118 and the foot switch 119 shown in FIG. 2 are suitably used when performing a small amount of liquid injection operation.
  • a test injection as described above, or when connecting an extracorporeal circuit part (for example, an extension tube) and an in-vivo circuit part (for example, a catheter), air is injected into the injection circuit.
  • an extracorporeal circuit part for example, an extension tube
  • an in-vivo circuit part for example, a catheter
  • the injection conditions other than the injection amount should be the same for the test injection and the main injection in order to equalize the effect (for example, contrast effect) of the medicinal solution injection with the subsequent main injection.
  • a chemical solution for example, a contrast agent
  • the injection control unit 101 controls the operation of each part so that the chemical solution is injected at the injection speed and the mixing ratio equal to the main injection. It is preferable to do.
  • an injection operation of a non-mixed drug solution for example, a contrast agent
  • a non-mixed drug solution for example, a contrast agent
  • the operator holds the connection part between the extracorporeal circuit part and the intracorporeal circuit part, and in the state where the liquid medicine is injected by operating the foot switch 119, the extracorporeal circuit part and the intracorporeal circuit part are connected. Connecting. In the meantime, the drug solution overflows from the tip of the extracorporeal circuit unit, and therefore, the extracorporeal circuit and the intracorporeal circuit can be connected without mixing air.
  • the injection control unit 101 controls the operation of each unit so that the injection operation of the chemical solution is performed at the set mixing ratio. .
  • the injection control unit 101 is included in the chemical injection device 100 and the imaging control unit 510 is included in the fluoroscopic imaging device 500 as illustrated in FIG.
  • both the injection control unit 101 and the imaging control unit 510 may be included in the chemical solution injection device 100, or both the injection control unit 101 and the imaging control unit 510 may be included in the fluoroscopic imaging device 500.
  • both the injection control unit 101 and the imaging control unit 510 may be included in a programmable computer device (not shown) separate from the chemical injection device 100 and the fluoroscopic imaging device 500. By doing so, it is not necessary for the chemical injection device 100 and the fluoroscopic imaging device 500 to have separate consoles, and the input unit and the display unit of each control unit can be shared. As a result, the configuration of the entire system can be simplified.
  • the injection control unit 101 can be incorporated in a unit different from the remaining other functions.
  • the injection condition determination (calculation) function can be incorporated into the imaging control unit 510 and the remaining other functions can be incorporated into the injection control unit 101.
  • the injection condition determination (calculation) function can be incorporated into the imaging control unit 510 and the remaining other functions can be incorporated into the injection control unit 101.
  • Data that is insufficient when determining the injection conditions may be input from the imaging control unit 510, or may be transmitted from the injection control unit 101 to the imaging control unit 510.
  • the function of the injection control unit 101 and the function of the imaging control unit 510 can be realized by using various hardware as required, but the main body is realized by the function of the CPU corresponding to the computer program.
  • the computer program is at least part of the procedure described above, for example, In the two-stage injection mode, for each of the first injection phase and the second injection phase, receiving the input of the mixing ratio of the first chemical liquid and the second chemical liquid; Setting injection conditions for the first chemical solution and the second chemical solution so that the first chemical solution and the second chemical solution are injected at the accepted mixing ratio; Controlling the operation of the first drive mechanism and the second drive mechanism according to the set injection conditions; Can be implemented as a computer program for causing a medical imaging apparatus 100, a fluoroscopic imaging apparatus 500, or a fluoroscopic imaging system including the chemical liquid injection apparatus 100 and the fluoroscopic imaging apparatus 500 to execute.
  • the injection head 110 and the console 112 shown in FIG. 2 can be integrally configured.
  • the console 112 is also arranged in the examination room. Since the hand switch 118 can be used to start and stop the injection operation, the operator can control the start and stop of the injection operation in the operation chamber by the hand switch 118.
  • the two piston drive mechanisms 130a and 130b are mounted on the common injection head 110.
  • the chemical solution injection device has two injection heads each equipped with one piston drive mechanism, and at the time of injection, the injection control unit 101 links each injection head with each other to mix a plurality of chemical solutions. You can also.
  • the chemical solution injector 100 can further include a load cell that detects the injection pressure.
  • the load cell can be provided in the presser 131 (see FIG. 3), for example. As shown in FIG. 3, in the case of having a plurality of pressers 131, at least one of them may have a load cell.
  • the injection pressure can also be detected by measuring the current of the motor that is the drive source of the piston drive mechanisms 130a and 130b. When the load acting on the presser 131 increases, the motor current increases according to the load. This is used for detecting the injection pressure using the motor current.
  • the detection of the injection pressure may be either one of detection using a load cell and detection using a motor current, or both may be used in combination. When both are used together, the injection pressure is usually detected by the load cell, and the injection pressure can be measured using the measurement result of the motor current only when the load cell fails.
  • the chemical liquid injector 100 can further include an RFID module 166.
  • RFID module 166 is for reading data from the RFID tag 352 and / or for recording data in the RFID tag 352. Since the chemical liquid injector 100 includes the RFID module 166, the data recorded in the RFID tag 352 can be used to control the operation of the chemical liquid injector 100 by the injection control unit 101.
  • the same components as those shown in FIG. 1 are denoted by the same reference numerals as those in FIG. 1, and description thereof is omitted here.
  • the RFID module 166 has an RFID control circuit 164 and an antenna 165, reads data recorded in the RFID tag 352 by the antenna 165, transmits the read data to the injection control unit 101, and / or the injection control unit.
  • the data transmitted from the terminal 101 can be recorded on the RFID tag 352.
  • the RFID control circuit 164 controls data transmission / reception operations in the RFID module 166. That is, the RFID module 166 functions as a reader that reads data from the RFID tag 352 or a reader / writer that records data in the RFID tag.
  • the antenna 165 of the RFID module 166 is built in the injection head 110 (see FIG. 2), and data is automatically received from the RFID tag 352 when a container 350 containing a chemical is appropriately attached to the injection head 110.
  • the unit may be a handy type unit other than the injection head 110, and the operator reads the data from the RFID tag 352 by bringing the unit and the RFID tag 352 relatively close to each other. You may do it.
  • the data recorded in the RFID tag 352 includes various data relating to the chemical solution contained in the container 350, such as the manufacturer, the type of chemical solution, the product number, and the contained components (particularly, the iodine-containing concentration when the chemical solution is a contrast agent). ), Amount of stored chemical, lot number, expiry date, etc.
  • various data related to the syringe 220 for example, a unique identification number such as a manufacturer and a product number, an allowable pressure value, a capacity of the syringe, a piston stroke, dimensions of necessary parts, a lot number, and the like can be included. At least a part of these data can be transmitted to the fluoroscopic imaging apparatus 500.
  • the chemical injection device 100 can further include a voice recognition unit (not shown) as a data input interface.
  • the voice recognition unit can include a microphone that acquires the voice generated by the operator and a voice recognition device that recognizes the voice acquired by the microphone and converts it into an operation signal for the chemical liquid injector 100.
  • the installation location of the voice recognition device may be arbitrary, but the microphone is preferably installed near the operator, for example, the injection head 110 or the vicinity thereof.
  • the operator can input or set the injection conditions of the chemical without touching the injection head 110 and the console 112.
  • the extension tube is preferably equipped with a mixing device that ensures good mixing of the contrast agent and saline.
  • a mixing device that ensures good mixing of the contrast agent and saline.
  • the extension tube includes a first tube 231a that connects the syringe filled with the contrast medium and the mixing device 241; a second tube 231b that connects the syringe filled with the physiological saline and the mixing device 241; And a third tube 231c connected to a liquid outlet (detailed below) of the mixing device 241 and extending toward the patient side.
  • the first and second tubes 231a and 231b may be connected to the conduit portion of the syringe via connectors 239a and 239b, respectively.
  • the third tube 231c may be connected to a catheter or the like via the connector 239c.
  • at least one of the connectors 239a and 239b connected to the first tube 231a and the second tube 231b may include a one-way valve. At least one may have a release function.
  • the mixing device 241 includes a first chamber that is a swirl flow generation chamber 242a that generates a swirl flow, and a second chamber that is a constriction chamber 242b that concentrates the swirl flow in the axial direction.
  • a main body 242 is provided.
  • the swirl flow generation chamber 242a has a cylindrical inner space
  • the constriction chamber 242b has a conical inner space coaxial with the swirl flow generation chamber 242a.
  • the cross-sectional shape in the short direction of the swirl flow generating chamber may be various shapes formed from a circle, an ellipse, or other curves.
  • the swirl flow generation chamber can be configured to have a narrowed shape that narrows as it approaches the narrowed chamber.
  • a conduit portion 243a to which the first tube 231a is connected is provided on the upstream side of the main body portion 242 of the mixing device 241, and a conduit portion 243c to which the third tube 231c is connected is provided on the downstream side.
  • the conduit portion 243b to which the second tube 231b is connected is disposed at a position upstream from the center of the swirl flow generation chamber 242a (details below).
  • the contrast agent flows from the conduit portion 243a and the physiological saline flows from the conduit portion 243b, and both drug solutions are mixed in the mixing device. Thereafter, the mixed drug solution of the contrast medium and physiological saline flows out from the conduit portion 243c as a liquid outlet.
  • the conduit portion 243a into which a high specific gravity chemical solution flows is provided in the central portion of the upstream side wall surface of the swirl flow generation chamber 242a on the upstream side in the flow direction.
  • the conduit portion 243c serving as the liquid outlet is provided so that the center line of the conduit portion 243c and the center line of the conduit portion 243a coincide, that is, both are coaxial.
  • the conduit portion 243b into which the chemical liquid having a small specific gravity flows is disposed on the side surface of the swirl flow generation chamber 242a and extends in the tangential direction of the circumference of the swirl flow generation chamber 242a having a circular cross section.
  • the conduit portion 243b is provided at a position shifted to the peripheral side from the central axis of the cylindrical space included in the swirl flow generation chamber 242a, and thereby, the chemical liquid having a small specific gravity flowing from the conduit portion 243b.
  • the swirl flow is generated. More specifically, as shown in FIG.
  • the flow path 241fb is configured to extend in the circumferential tangential direction of the curved inner surface of the swirl flow generation chamber 242a, and thereby flows from this flow path.
  • the chemical becomes a swirl flow.
  • the constriction chamber 242b has an inclined inner surface that swells toward the downstream side in the flow direction, so that the generated swirling flow is concentrated in the direction of the central axis of the vortex. Become.
  • the conduit portion 243a into which the contrast agent flows is in communication with the swirling flow generation chamber 242a through the flow path 241fa.
  • the chemical liquid having a large specific gravity can be introduced into the swirling flow generating chamber in a direction parallel to the central axis of the swirling flow of the chemical liquid having a small specific gravity. That is, the chemical liquid having a large specific gravity is introduced in a direction parallel to the central axis of the cylindrical space included in the swirl flow generation chamber.
  • the conduit part into which the physiological saline flows is in communication with the swirl flow generation chamber via the flow path 241fb.
  • the inner diameter of the flow path 241fb may be smaller than the inner diameter of the flow path 241fa into which the contrast agent flows.
  • the mixing device 241 configured as described above, for example, when a contrast medium and physiological saline are flowed into the device, the contrast medium that has flowed into the swirl flow generation chamber from the flow path 241fa flows toward the downstream side in the axial direction. Become.
  • the physiological saline flowing into the swirl flow generation chamber from the flow path 241fb becomes a swirl flow swirling along the curved inner surface of the same chamber, and the swirl flow of the physiological saline is guided to the stenosis chamber and swirls. Concentrate in the direction of the central axis of the flow.
  • a vortex is known as a Rankine vortex, and the inertial force of the swirling flow can be concentrated in the vicinity of the rotation axis of the vortex.
  • both chemicals will be mixed well. That is, in this example, it is possible to obtain a diluted contrast agent in which the contrast agent and physiological saline are well mixed. As a result, there is no unevenness in the concentration of the contrast agent. An excellent contrast effect can be expected compared to the case of the extension tube.
  • At least the drug solution injection device 100 and the fluoroscopic imaging device 500 may be connected to a medical network.
  • the injection speed, injection time, and injection volume of the drug solution injected by the drug solution injection device 100 (when multiple injections are performed in one examination and / or treatment, the injection amount for each injection) And the total injection amount of a series of injections), the injection graph, the type of the injected chemical solution, the injection result including the mixing ratio when the two-stage injection mode is implemented, and the imaging conditions by the fluoroscopic imaging device 500 are medical It can be stored as injection data in a fluoroscopic imaging device, RIS (Radiology Information System), PACS (Medical Image Storage Management System), HIS (Hospital Information System), etc. through a network.
  • RIS Radiology Information System
  • PACS Medical Image Storage Management System
  • HIS Hospital Information System
  • the stored injection data is used for management of injection history.
  • the injection amount or the like can be recorded in the chart information as a used chemical solution or used for accounting.
  • physical information such as the body weight of the subject, ID, name, examination site, and examination method can be acquired from RIS, PACS, HIS, etc., and displayed on the drug solution injector, and injection can be performed accordingly.
  • Such information may be transmitted from the chemical injection device 100 to the RIS, PACKS, HIS, or the like via the fluoroscopic imaging device 500, or may be transmitted directly from the chemical injection device 100 to the RIS, PACKS, HIS, or the like.
  • the chemical injection device 100 includes the RFID module 166
  • data transmitted to the RIS, PACKS, HIS, or the like can include data acquired from the RFID tag 352 by the RFID module 166.

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CN201880038643.1A CN110753562B (zh) 2017-04-12 2018-04-11 化学液体注入装置
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KR20200053706A (ko) * 2018-11-08 2020-05-19 메디허브 주식회사 무통 마취 주사장치
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EP3831424A1 (en) * 2019-12-02 2021-06-09 Siemens Healthcare GmbH Controller for a contrast media power injector
JP2021520991A (ja) * 2018-04-12 2021-08-26 ノードソン コーポレーションＮｏｒｄｓｏｎ Ｃｏｒｐｏｒａｔｉｏｎ 多成分材料を分注するためのシステム及び方法
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WO2024214782A1 (ja) * 2023-04-13 2024-10-17 株式会社根本杏林堂 薬液注入装置及び制御方法

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