WO2018134708A1 - Mécanisme d'insertion de canules pour appareil de type patch - Google Patents

Mécanisme d'insertion de canules pour appareil de type patch Download PDF

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Publication number
WO2018134708A1
WO2018134708A1 PCT/IB2018/050166 IB2018050166W WO2018134708A1 WO 2018134708 A1 WO2018134708 A1 WO 2018134708A1 IB 2018050166 W IB2018050166 W IB 2018050166W WO 2018134708 A1 WO2018134708 A1 WO 2018134708A1
Authority
WO
WIPO (PCT)
Prior art keywords
cannula
drive
rack
gear
base
Prior art date
Application number
PCT/IB2018/050166
Other languages
German (de)
English (en)
Inventor
Seline STAUB
Ursina Streit
Original Assignee
Tecpharma Licensing Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH00062/17A external-priority patent/CH713378A2/de
Application filed by Tecpharma Licensing Ag filed Critical Tecpharma Licensing Ag
Priority to EP18701588.8A priority Critical patent/EP3570908B1/fr
Publication of WO2018134708A1 publication Critical patent/WO2018134708A1/fr
Priority to US16/516,051 priority patent/US11197954B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1585—Needle inserters

Definitions

  • the invention relates to injection and infusion devices, in particular injection and infusion devices, which are applied to the administration of a substance directly to the skin of the person using, in particular glued, which are also known as patch devices.
  • the invention relates to mechanisms for inserting cannulas, in particular so-called soft cannulas, which are made, for example, from fluoropolymers (such as polytetrafluoroethylene) or property-like materials.
  • An administration device for fluid products, in particular an infusion pump or an injection device, in particular a patch infusion pump or a patch injector, may in principle be suitable for the administration of a variety of drugs, provided that the drug has a consistency can be distributed with the infusion pump or the injection device.
  • the aforementioned consistency meaning for example the viscosity, may make it necessary to optimize the construction of the injection device or the infusion pump in order to make the administration of the medicament as pleasant as possible for the user.
  • patch devices patch infusion pump, especially in the treatment of diabetes with insulin, or patch injectors, especially for the administration of high viscosity antibody formulations.
  • the devices are stuck by means of plaster directly on the body of the user and then no longer need to be held manually or stowed for example in a holster.
  • the term "medicament” includes any fluid medical formulation suitable for controlled administration by an agent, such as an agent.
  • a cannula or hollow needle for example comprising a liquid, a solution, a gel, an emulsion or a fine suspension containing one or more medicinal agents.
  • Drug may be a single drug composition or a premixed or co-formulated multi-drug composition from a single container.
  • Medicament includes medicaments such as peptides (eg insulins, insulin-containing medicaments, GLP-1-containing as well as derived or analogous preparations), proteins and hormones, biologically derived or active ingredients.
  • Substances active substances based on hormones or genes, nutrient formulations, enzymes and other substances both in solid (suspended) or liquid form but also polysaccharides, vaccines, DNA or RNA or oligonucleotides, antibodies or parts of antibodies as well as suitable basic, auxiliary and carriers.
  • Patch devices in the sense of the present application ie patch infusion pumps or patch injectors, often comprise so-called (cannula) insertion mechanisms, which serve to introduce a cannula into the tissue of the person using it.
  • Some of these patch devices use soft infusion cannulas made of plastic, especially biocompatible fluoropolymers, for administering the fluid medicament. This has the advantage that the soft infusion cannula potentially causes less pain to the user using the surrounding tissue than an infusion cannula made of a rigid material such as steel.
  • Another advantage of the soft infusion cannulae is that it can not break with soft cannulas.
  • an insertion cannula (or an insertion needle) made of a rigid material such as steel is used.
  • This insertion cannula is passed through the infusion cannula prior to insertion of the infusion cannula and protrudes beyond the open end of the infusion cannula.
  • the insertion cannula is inserted into the tissue together with the infusion cannula during insertion.
  • the infusion cannula is fixed in this position and the insertion cannula is withdrawn from the tissue. Only the soft infusion cannula remains in the tissue.
  • the inner lumen of the insertion cannula is part of the fluid pathway over which the fluid medicament is administered.
  • the insertion cannula in the retraction described above is not completely pulled out of the infusion cannula, so that the fluid to be administered drug is passed from the insertion cannula into the infusion cannula and from there via one or more openings of the infusion cannula into the tissue of the person using.
  • US Pat. No. 7,127,727 B2 discloses a patch infusion pump 10 with an insertion mechanism with which a soft infusion cannula 38 is introduced into the tissue with the aid of an insertion cannula 62.
  • the mechanism described uses for the insertion movement of the infusion cannula and the subsequent withdrawal of the insertion cannula separate springs 70 resp. 82, so at least one spring 70, which provides the energy for the insertion movement and at least one spring 82, which provides the energy for the return movement.
  • a patch infusion pump 100 with insertion mechanism with which a soft infusion cannula 176 is introduced into the tissue with the aid of an insertion cannula 174.
  • the drive of the insertion mechanism is realized with a torsion spring 181.
  • the drive spring 181 is connected to a slide 184 via an arm system 183a, 183b.
  • the two partial arms 183a and 183b are connected to each other via a hinge, so that the two partial arms 183a, 183b are rotatable in a plane relative to each other.
  • the disclosed insertion mechanism allows the execution of the insertion movement and the withdrawal movement with a spring 181.
  • distal and proximal are used in reference to position and direction indications.
  • Distal means from the point of view of the fluid path of the administering device to the person using (in the direction of administration or dispensing) and proximally according to the reverse.
  • the movement of an infusion cannula which is introduced into the tissue of the person using it, is a movement in the distal direction, also referred to below as insertion direction.
  • the retraction movement of an insertion cannula back into the housing of an administering device thus movement in the proximal direction.
  • One aspect of the invention includes a cannulation mechanism for a patch device, particularly a patch infusion pump or a patch injector.
  • a cannulation mechanism for a patch device particularly a patch infusion pump or a patch injector.
  • insertion mechanisms for patch infusion pumps which, however, can also be used in the same form for patch injectors, or could also be used in other administration devices without deviating from the invention.
  • the patch infusion pump includes a housing.
  • the housing may be constructed in one or more parts and comprises a so-called base, which represents the region of the housing which is arranged on the skin of the user using plaster.
  • the base itself may be designed in several parts and may also include inserts, in particular guide elements, which are mounted during assembly to the base. Alternatively, the base can also be designed as an insert for the housing.
  • the patch infusion pump includes an insertion mechanism for placing a flexible or soft infusion cannula in tissue of the user.
  • the flexible or soft infusion cannula is introduced into the tissue with the aid of an insertion cannula.
  • the insertion mechanism of the patch infusion pump comprises a toothed wheel which can be set in motion, in particular rotation, by a source of energy, and which in particular is mounted rotatably but non-displaceably on the base.
  • the insertion mechanism comprises a carriage on which the insertion cannula is fixedly arranged, wherein the carriage is operatively coupled to the gear, so that a movement, in particular rotation of the gear movement of the carriage and thus the insertion cannula for May have consequences.
  • the infusion cannula is drawn over the insertion cannula, which is deposited in the tissue of the user using the insertion cannula as part of the insertion process.
  • the insertion mechanism of the patch infusion pump includes a guide slot (advantageously with one or more sub-gates) along which the gear may be passed over serrations or pin assemblies, with rotation of the gear via the guide along the serrations or pin assemblies can be transformed into a translation of the gear axis relative to the guide slot.
  • a plurality of serrations and pin assemblies are disposed along the guide slot such that the gear axis is staggered in different directions relative to the guide slot in a staggered manner.
  • the gear is only partially occupied by teeth at its periphery, whereby it can be divided into two sectors, a first sector which is toothed and a second sector in which no teeth are present.
  • the gear could also have more than two sectors, with toothed and untoothed sectors alternating.
  • the guide slot comprises a first toothed part raceway and a second toothed part raceway, the first and second part raceways facing each other (antiparallel or mirrored), and the teeth of the first sector of the gearwheel first at the toothing of the unroll the first part of the track and then roll on the second part of the track on further rotation of the gear in the same direction and the teeth of the first sector are either in engagement with the first part of the gate or the second part of the gate, but not in engagement with both simultaneously.
  • this sequential engagement of the teeth results in the guide link moving in a first direction relative to the gear axis during engagement of the teeth of the first sector with the teeth of the first sub-link along the first sub-gate and subsequently engaging the teeth of the first sector moves in the toothing of the second part of the slide along the second part of the slide in a second direction, which is opposite to the first direction, so that a reciprocating motion between the guide slot and gear axis is formed.
  • Optionally may exist between the engagement of the teeth of the first sector with the teeth of the first part of the gate and the engagement of the teeth of the first sector in the teeth of the second part of a stage in which the teeth of the first sector are not engaged with a toothing, so that the gear can rotate without the gear axis shifts relative to the guide slot.
  • the maximum angle comprising the first sector of the gear is defined as follows:
  • the relative movement between the first sectionkulisse and the gear, while the gear rolls on the first part of the gate and the teeth of the first sector in engagement with the teeth of the first part of the gate corresponds to the path the insertion cannula during insertion of the infusion cannula into the tissue.
  • the gear may be a friction wheel, wherein the partial scenes then instead of toothing or pin arrangements comprise corresponding friction surfaces along which the friction wheel can move non-positively.
  • the cannula insertion mechanism comprises a rotationally fixed and coaxially arranged on the gear inlet wheel, in particular a Einschaltahnrad.
  • This inlet wheel serves to transmit kinetic energy from a power source to the gear, wherein the gear is in particular set in rotation.
  • the inlet wheel may be constructed and manufactured as a part together with the wheel, alternatively, the gear and the inlet wheel may be made as two separate parts and fixedly connected together during assembly, for example via a common axle or by joining techniques such as Gluing or welding.
  • the cannula insertion mechanism comprises an elongated transmission element guided on the housing, in particular on the base, which can be brought into contact with the inlet wheel, in particular so that energy can be transmitted.
  • the linear relative movement between the inlet and the transmission element can be translated into a rotation of the inlet wheel and thus a rotation of the gear.
  • the contact between transmission element can be positive or non-positive.
  • the inlet wheel is rotatable, but not displaceably mounted on the base and the transmission element can be moved in particular linearly to the base and thus to the inlet.
  • the transmission element can be moved by way of example by a drive spring as an energy source.
  • the drive spring may be a compression spring which expands upon release of energy.
  • the drive spring may be a tension spring which contracts upon release of energy.
  • a hydraulic or pneumatic drive (cylinder / piston) can be used for the displacement of the transmission element.
  • an electric drive for example an electric motor, which is connected to the transmission element via a toothed wheel or a worm wheel, a linear motor, in particular a piezoelectric oscillator, or a solenoid drive, can also be used for the displacement of the transmission element.
  • the electric motor may be a DC motor or else a stepping motor, with further variants being familiar to the person skilled in the art.
  • attracting or repelling magnets could be used for the drive.
  • An advantage of the electric drives described is that they can be designed self-locking, that is, it does not need actual devices that hold the cannula insertion mechanism in the initial state or final state. This self-locking can be realized, for example, via the internal resistance (cogging torque) of an electric motor, if this is not switched on, for example in DC motors with permanent magnet. Alternatively, this self-locking can also be achieved by means of a worm wheel, which couples the motor and the transmission element.
  • the inlet wheel is configured as a single-pinion gear and the transmission element as a toothed rack.
  • the rack is linearly guided on the base (linear) and the single-index gear with the gear rotatably mounted on the base.
  • the rack has a toothing along a longitudinal dimension which can be brought into engagement with teeth of Einschaltahnrades, whereby a movement of the rack is convertible into a rotation of Einschaltahnrad and gear, wherein the rack can be offset by energy from a spring or an electric drive in motion.
  • the Einleitrad and thus the gear are rotated by an electric drive in rotation, wherein the rack is omitted, and in this aspect Einleitrad and gear advantageous rotating, but not displaceable at the base or the Housing are stored.
  • the Einleitrad be designed in particular as a bevel gear, especially as a bevel gear to make the introduction of energy efficient and space-saving.
  • the inlet wheel can be driven by an electric motor, which is connected for example via a gear and another bevel gear, which serves as a transmission element, and which is fixedly connected to the axis driven by the motor, with the inlet wheel, the further bevel gear in this embodiment takes over the function of the transmission element.
  • the transmission element may be a chain, a string or a belt which couples the inlet wheel to the electric drive.
  • the invention includes a cannulation mechanism for a patch device
  • a housing comprising a base, which can also serve as the basis for the patch device and which can be attached directly or indirectly to the skin of the user,
  • At least one guideway fixedly attached to the housing and defining at least part of an insertion path
  • a carriage which is displaceably mounted in the at least one guideway in and against an insertion direction along the guideway
  • a drive spring in particular a torsion spring, whose axis is approximately perpendicular to the at least one guide track and can be fixedly attached to the base or the housing with a first end of the drive spring,
  • toothing of the toothed wheel comprises a first sector of the toothed wheel, and wherein a second sector of the toothed wheel does not comprise toothing
  • a self-contained guide slot which is fixedly arranged on the carriage, which extends at a distance from the at least one guideway, wherein the distance results from the geometric dimensions of the carriage, drive spring and gear, and
  • the guide slot comprises at least one partial slide which runs concurrently with the guide track
  • the at least one partial slat comprises in each case a toothing or pin arrangement which, depending on the rotational orientation of the toothed wheel, can be brought into engagement with the teeth of the first sector
  • the gear is set by the release of energy from the drive spring in a rotational movement and thereby the carriage with the steel cannula by engagement of the teeth of the gear with the toothing or pin arrangement of the at least one sub-set in a movement along the at least one guideway is displaceable.
  • the invention includes a cannula insertion mechanism for a patch device having a soft plastic cannula, particularly PTFE, which is designed to be pulled over the steel cannula.
  • the invention includes a cannula insertion mechanism for a patch device, wherein the drive spring is a torsion spring and has a helical shape.
  • the invention includes a cannula insertion mechanism for a patch device, wherein the drive spring is a torsion spring that is in the form of a coil spring.
  • the invention includes a cannula insertion mechanism for a patch device, wherein the gear comprises a second sector in which there is no toothing.
  • the invention comprises a cannula insertion mechanism for a patch device, wherein the guide slot comprises two partial toothed lobes, the two partial lobes being in the same plane and the toothings spaced from each other, and the spacing of the two partial lobes from each other is determined by the diameter of the gear without the teeth, in particular by the pitch circle diameter of the gear.
  • the invention includes a cannula insertion mechanism for a patch device, wherein the gear is rotatably mounted on the base such that upon release of energy from the drive spring, the gear is rotatable relative to the carriage.
  • the invention comprises a drive for an insertion mechanism for a delivery device
  • a guideway formed in or on the base defining a proximal and a distal end and a straight line or curve therebetween
  • a slide is provided so as to be rotationally fixed on the base and displaceable along or in the guideway between a proximal carriage end position and a distal carriage end position, in particular to be moved back and forth,
  • a drive track connected to the carriage comprising a plurality of drive sections, wherein a first drive section and a second drive section are opposite each other and parallel to the straight line or to the curve of the guide track,
  • the energy source via a one- or multi-part transmission element and a Einleitrad with the drive wheel can be coupled, the Einleitrad secured against rotation is connected to the drive wheel, and wherein the transmission element is arranged displaceably or rotatably to the base.
  • the invention comprises a drive for an insertion mechanism for an administering device according to the preceding aspect, wherein the transmission element is a rack with at least one toothing and slidably disposed on the base and wherein the inlet wheel is a gear whose teeth are in Intervention with a toothing of the rack can be brought.
  • the transmission element is a rack with at least one toothing and slidably disposed on the base and wherein the inlet wheel is a gear whose teeth are in Intervention with a toothing of the rack can be brought.
  • the invention comprises a drive for an insertion mechanism for an administering device according to the preceding aspect, wherein the base further comprises a linear rack guide, in particular in the form of a groove, and wherein the rack comprises at least one guide element, in particular at least two cams , via which the rack is connected to the base and wherein the rack is displaceable along the rack guide.
  • the invention comprises a drive for an insertion mechanism for an administering device according to the preceding aspect, wherein the energy source is a tension or compression spring, one end of the tension or compression spring being fixed to the base and the second end fixed the rack is arranged and wherein the tension or compression spring for driving the drive for the insertion mechanism of the administering device is biased or biased and wherein a release of the prestressed tension or compression spring a force acts on the rack, which this along the rack guide in motion offset and whereby in the sequence introduction and drive wheel are rotated.
  • the energy source is a tension or compression spring
  • one end of the tension or compression spring being fixed to the base and the second end fixed the rack is arranged and wherein the tension or compression spring for driving the drive for the insertion mechanism of the administering device is biased or biased and wherein a release of the prestressed tension or compression spring a force acts on the rack, which this along the rack guide in motion offset and whereby in the sequence introduction and drive wheel are rotated.
  • the invention comprises a drive for an insertion mechanism for an administering device of a preceding aspect, the drive further comprising a release device, the release device comprising at least the following elements, a retaining element fixedly attached to the base, fixed to the rack arranged further holding element, and a connecting element, with which the holding element and the further holding element are releasably connected to each other, so that when the holding element and the further holding element are connected to each other via the connecting element, the rack is held or fixed relative to the base.
  • the invention comprises a drive for an insertion mechanism for an administering device according to the preceding aspect, wherein the holding element and the further holding element are bores and the connecting element is formed as a pin or splint, which is insertable into the bores and thereby the rack is fixable to the base
  • the invention comprises a drive for an insertion mechanism for an administering device, wherein the rack has a first and a second toothing, wherein the first toothing is engageable with the inlet gear designed as a gear and wherein the energy source on the second toothing with the rack can be coupled.
  • the invention includes a drive for an insertion mechanism for an administering device, wherein the power source is an electric motor having an electric motor driving axis which is rotatable by the electric motor directly or via a gear and coaxial and fixed to the electric motor driving axis Gear is arranged, which is engageable with the second toothing of the rack.
  • the power source is an electric motor having an electric motor driving axis which is rotatable by the electric motor directly or via a gear and coaxial and fixed to the electric motor driving axis Gear is arranged, which is engageable with the second toothing of the rack.
  • the invention comprises a drive for an insertion mechanism for an administering device, wherein the Einleitrad is designed as a first bevel gear, in particular as a bevel gear, and the transmission element is also designed as a second bevel gear, in particular as a bevel gear, said first bevel gear and second bevel gear are engaged with each other, so that a rotation of the second bevel gear causes a rotation of the first bevel gear and wherein the axes of rotation of the first and second bevel gears are at an angle of approximately 90 ° to each other.
  • the Einleitrad is designed as a first bevel gear, in particular as a bevel gear
  • the transmission element is also designed as a second bevel gear, in particular as a bevel gear
  • said first bevel gear and second bevel gear are engaged with each other, so that a rotation of the second bevel gear causes a rotation of the first bevel gear and wherein the axes of rotation of the first and second bevel gears are at an angle of approximately 90 ° to each other.
  • the invention comprises a drive for an insertion mechanism for an administering device, wherein the second bevel gear is rotatable by an electric drive or a spring.
  • the invention comprises a drive for an insertion mechanism for an administering device, wherein on the carriage a supply line with a lumen is arranged and guided in or on the carriage, through which a substance to be administered, in particular a fluid medicament, can be passed ,
  • the invention includes a drive for an insertion mechanism for an administering device, wherein at the distal end of the carriage, a cannula bridge is disposed, at which the lead terminates and a proximal end of an insertion cannula is disposed with a lumen, the lumen of the Supply line and the lumen of the insertion cannula are connected to each other, so that the substance to be administered can be passed from the supply line into the insertion cannula, and wherein the insertion cannula participates a displacement of the carriage in the distal as well as in the proximal direction.
  • One aspect of the invention comprises a cannulation mechanism for a patch device, comprising a drive as previously described, an infusion cannula having a distal and a proximal end through which the insertion cannula can be passed, a cannula carrier being fixedly secured to the proximal end of the infusion cannula , wherein on the cannula carrier, a connecting means, in particular one or more Schnapparme, is arranged, via which the cannula carrier is detachably connectable to the cannula bridge, when the insertion cannula is passed through the infusion cannula so far that the cannula carrier rests against the cannula bridge.
  • a connecting means in particular one or more Schnapparme
  • An aspect of the invention comprises a patch device, in particular a patch pump or a patch injection device, with a cannula insertion mechanism according to the preceding aspect.
  • the invention comprises a cannula insertion mechanism for a patch device, wherein in the rotation of the gear, the teeth of the first sector of the gear in a first phase engage with the toothing of the first part of the gate, whereby on the arrangement of the first Part slide on the carriage of the carriage along the guide path in the insertion direction is moved and wherein the teeth of the first sector of the gear engage in a second phase in engagement with the toothing of the second part of the gate, whereby on the arrangements of the first part of the sledge slide on the sled along the guideway the insertion direction is moved.
  • the invention includes a cannula insertion mechanism for a patch device wherein the first sector of the gear defines a pitch diameter with its teeth, whereby the arc resulting from the sector angle of the first sector and the pitch diameter results in the insertion route of the cannula insert ,
  • FIG. 14a A vertical section of the arrangement from FIG. 14a in the region of the triggering mechanism.
  • FIG. 12 A top view of the arrangement of the cannula insertion mechanism from FIG. 12 after insertion, but before the withdrawal of the insertion cannula 104a
  • FIGS. 1 to 10 show the basic cannula insertion mechanism of a patch infusion pump 1, as it forms the basis for the embodiments according to the invention.
  • the cannula insertion mechanism shown in Figures 1 to 10 is already described in detail in the Swiss patent application no. 00062/17, which is why this is expressly incorporated herein by reference in the present application.
  • FIG. 1 shows an exploded view of the basic cannula insertion mechanism.
  • Figure 2 shows a view of the basic insertion mechanism in the initial state.
  • Figure 3a shows a vertical section through the basic cannula insertion mechanism in the initial state.
  • FIG. 3b shows a detail from FIG. 3a.
  • Figure 4 shows a horizontal section through the cannula insertion mechanism in the initial state.
  • Figures 5 and 6 show the cannula insertion mechanism immediately after the mechanism is triggered in two different views.
  • FIGS. 7 to 10 now show horizontal sections through the cannula inserting mechanism in the further stages of the insertion process, FIG. 10 representing the final state.
  • the patch infusion pump 1 comprises a housing 2, of which in FIGS. 1 to 10 above all the base 2a can be seen, which in turn can be designed as a housing part or as a housing insert.
  • the housing 2 is glued in the region of the base 2a by means of a plaster on the skin of the person using.
  • the guide tracks 2b which are listed as grooves, are arranged on the base 2a. Further, the spring support 2c, the cannula guide 2d, the release arms 2g and the guides 2j designed as openings in the base 2a are disposed on the base.
  • the basic cannula insertion mechanism further comprises a carriage 3, which is slidably guided in the guideways 2b at the base by means of the guide elements 3e.
  • the carriage further comprises the cannula bridge 3d, on which the insertion cannula 4a with its insertion cannula support 4b is fixedly arranged (see in particular FIG. 4).
  • the insertion cannula is open at both ends so that fluid can be passed through the insertion cannula 4a.
  • the supply line 9 which is in fluid communication with the insertion cannula 4a and through which fluid can be passed, for example, from a reservoir into the insertion cannula 4a.
  • the supply line 9 runs partly on the carriage 3.
  • the carriage 3, as shown in FIGS. 1 to 10, has roughly the shape of an oval.
  • the oval has the function of a guide slot 3a, which consists of the first part of the backdrop 3b, the second part of the scenery 3c and the two sheets 3h, which connect the first part of the backdrop 3b with the second part of the scenery 3c.
  • the inside of the oval is open.
  • the first part backdrop 3b and the second part scenery 3c have opposing serrations.
  • the spring 6 On the spring holder 2c one end of the drive spring 6, in the case shown a helical torsion spring, fixed, the spring 6 is arranged coaxially with the spring holder 2 and is also supported by the spring holder.
  • the second end of the spring is fixedly connected to the gear 7, wherein the gear 7 is rotatably mounted to the spring holder 2 c on the same and wherein between the spring holder 2 c and the gear 7, the spring 6 is arranged.
  • the gear axis 7d extends through the oval of the carriage 3.
  • the gear 7 has a first sector 7a, which has teeth with teeth 7c. Further, the gear 7 comprises a second sector 7b without teeth.
  • the two sectors 7a and 7b are supported by the aforementioned oval, wherein the teeth of the first sector 7a can move alternately into engagement with the serrations of the first part raceway 3b and the second part raceway when the gear wheel 7 rotates relative to the base 2a and the slide 3.
  • the basic insertion mechanism comprises a cannula ensemble 5 comprising a cannula support 5b.
  • the cannula support 5b, the infusion cannula 5a is firmly anchored.
  • the insertion cannula 4a protrudes through the cannula support 5b and the lumen of the infusion cannula 5a, wherein the distal tip of the insertion cannula 4a protrudes from the distal end of the infusion cannula 5a.
  • the insertion cannula 3a is withdrawn (out of the tissue) through the infusion cannula 5a, the insertion cannula 4a, after completion of retraction, still protruding into the infusion cannula 5a and thus closing the fluid connection Feed line 9 and infusion cannula 5a produces, so that the substance to be administered can be supplied to the person using.
  • the infusion cannula 5a is movably mounted together with the cannula support 5b on the insertion cannula 4a, wherein in the initial state cannula support 5b and the cannula bridge 3 are firmly but detachably connected to one another via the snap limbs 5c.
  • FIGS. 3a and 3b show partial vertical sections through the patch infusion pump 1, with FIG. 3b showing details of the cannula guide 2d.
  • the carriage 3 moves relative to the base.
  • the movement of the carriage and thus of the insertion cannula 4a and also of the infusion cannula (during insertion) is approximately parallel to the skin surface of the person using it.
  • the cannula guide 2d guides the insertion cannula 4a and the infusion cannula 5a in the direction of the tissue, as shown in FIG. 3b.
  • the cannula ensemble 5 comprises a guide tube 5e whose task is to mechanically stabilize the cannula ensemble 5 during the movement in the distal direction (see FIGS. 3a and 3b).
  • the guide tube 5e surrounds the infusion cannula 5a and is fixed at one end to the cannula carrier 5b.
  • the guide tube 5e has a longitudinal slot on its side facing the base 2a.
  • the guide tube 5e is opened along the slot in the area of the cannula guide 2d and from the infusion cannula 5a and the insertion cannula 4a separated and not passed through the base 2a in the direction of tissue - in the present example away from the base 2a.
  • the gear 7 is rotatably mounted on the spring holder 2c.
  • the drive spring 6 is arranged, which is designed as a helical torsion spring.
  • the drive spring could also have other shapes, in particular, for example, the spring with the spring holder integrated could be designed as a torsion bar, which would be firmly connected at one end to the gear 7.
  • one end of the drive spring 6 is fixedly connected to the spring holder 2c, the other fixed to the gear 7.
  • Energy, which is stored in the spring 6, so then converted into a rotation of the gear 7 relative to the base 2a become.
  • the gear 7 is divided into a first sector 7a with teeth 7c and a second sector 7b without teeth.
  • the guide slot 3a is fixedly arranged on the carriage 3 and comprises the first partial slot 3b and a second partial slot 3c.
  • the spring 6 is prestressed, so that a moment acts on the toothed wheel 7, which is transmitted via the teeth 7c to the first partial cam 3b on the carriage 3.
  • the carriage 3 pushes in the distal direction.
  • this movement is blocked, as can be seen for example in FIG.
  • release arms 2g are arranged on the base, which have a free end with tooth 2h.
  • one tooth 2h is in engagement with a tooth 3f of the carriage 3 in the initial state (the basic insertion mechanism in the variant shown has one respective tooth 3f on both sides of the carriage 3).
  • the insertion mechanism of the patch infusion pump 1 further comprises a release bracket 8.
  • the release bracket 8 is connected to the base 2a via the guide arms 8b, which are displaceably mounted in the guides 2j.
  • the release clamp further comprises the spring elements 8a, whose free ends 8d abut against the bulges 2i of the release arms 2g and thus resiliently press the release clamp in the distal direction.
  • the bay 8c of the release bracket 8 supports the gear axis 7d and also presses the gear in the distal direction (see, for example, Figure 2).
  • FIG. 4 shows a horizontal section through the insertion mechanism in the initial state.
  • the blocking zones 8e of the release bracket 8 prevent deflection of the free ends of the release arms 2g.
  • the insertion mechanism can now be released by displacing the release clip in the proximal direction against the spring force induced by the spring elements 8a.
  • the blocking zones 8e also shift in the proximal direction.
  • FIGS. 5 and 6 show the insertion mechanism when the release clip 8 is actuated.
  • the free ends 2h of the release arms 2g can now flex outward, permitting movement of the carriage 3 in the distal direction along the guideways 2b.
  • the force acting on the gear 7 torque from the spring 6 now causes the gear starts to rotate, in the illustrated basic insertion mechanism of the patch infusion pump 1 in the counterclockwise direction. Accordingly, the carriage 3 shifts in the distal direction, whereby the cannula ensemble 5 and the insertion cannula ensemble 4 also in Insertion be moved, resulting in the insertion of insertion cannula 4a and infusion cannula 5a in the tissue of the person using.
  • FIG. 7 shows the insertion mechanism during the movement in the insertion direction.
  • the movement in the distal direction continues until the teeth 7c are disengaged from the toothing of the first part gate 3b.
  • the cannula support 5b reaches the cannula guide 2d.
  • the cannula guide 2d comprises a funnel-like guide 2e, which then deflects the holding arms 5d of the cannula holder 5b inwards, whereby they are brought into engagement with the cannula holder 2f.
  • the snap arms 5c are in turn deflected outwards, whereby the engagement of the snap arms 5c in the cannula bridge 3d is released. Since there is still a torque applied to the gear 7, this continues to rotate in the counterclockwise direction ( Figure 8).
  • FIG. 8 shows the insertion mechanism when the cannulas 4a and 5a have been inserted, but before the withdrawal of the insertion cannula 4a.
  • the gear 7 rotates between the insertion and before the withdrawal of the insertion cannula 4a through an angle at which the teeth 7c are neither in engagement with the first part of the backdrop 3b nor the second part of the scenery 3c.
  • FIG. 8 shows the moment in which the teeth 7c are just engaged with the second part gate 3c.
  • FIGS. 11 to 17 An embodiment of the cannula insertion mechanism according to the invention is shown in FIGS. 11 to 17.
  • the identifiers in this embodiment were named analogously to the basic cannula insertion mechanism of FIG. 1 shown above, the numbering was made such that z. B. the base 2a of the design of Figure 1 is analogous to the part 102a of the embodiment of Figure 11. Since the function of the embodiment of FIG. 11 is also very similar to the function of the cannula insertion mechanism of FIG. 1, the differences between the mechanisms will be discussed below.
  • FIG. 11 shows an exploded view of parts of the patch infusion device 100.
  • FIG. 12 shows a view of the parts after assembly in the initial state.
  • FIG. 13a shows a plan view of the arrangement of FIG.
  • FIG. 14a shows the arrangement immediately after the triggering of the cannula inserting mechanism by the removal of the trigger pin 108.
  • FIGS. 13b and 14b show the states from FIGS. 13a and 14a, respectively, in the vertical sections MM and NN.
  • FIG. 15 shows the arrangement from FIG. 12 after the insertion of the infusion cannula 105a, but before the withdrawal of the insertion cannula 104a.
  • FIGS. 16 and 17 show the arrangement of FIG. 12 in the final state of the cannula insertion mechanism.
  • a difference between patch infusion pump 1 and patch infusion pump 100 is in the drive of the cannula insertion mechanism.
  • the gear 107 is not driven directly by a torsion spring 6.
  • the drive energy for the cannula insertion mechanism of the patch infusion pump 100 comes from the drive spring 106, which is designed as a compression spring.
  • One end of the compression spring 106 is disposed on the Druckfederwiderlager 102g, wherein the Druckfederwiderlager is fixedly disposed on the base 102a, respectively. Alternatively, it may be configured in one piece with the base.
  • the compression spring abutment 102g has a pin-shaped extension 1021, which can serve as a guide for the spring 106.
  • the second end of the compression spring 106 is mounted on the rack 110, more precisely on the spring bearing 110b and its pin-like extension 110e.
  • the rack 110 is displaceable, in particular linearly displaceable, mounted on the base 102a, for this purpose the rack comprises the in particular cam-shaped guide elements 110c (see FIG. 11) and the base 102a comprises the particular groove-shaped rack guide 102k in which the guide elements 110c are guided become.
  • FIG. 12 shows the cannula insertion mechanism in the initial state, in which the compression spring 106 is tensioned (compressed).
  • FIG. 17 shows the cannula insertion mechanism after the insertion of the infusion cannula 105a and the withdrawal of the insertion cannula 104a in its final state with the compression spring 106 at least partially relaxed. During the relaxation movement of the spring 106, the toothed rod 110 has moved in the distal direction.
  • the rack 110 includes the toothing 110a, which is engaged with the teeth of the inlet wheel 107e, so that a displacement movement of the rack 110 can be converted into a rotation of the inlet wheel 107e.
  • the inlet 107e is designed as a gear as shown in the figures.
  • the introduction gear 107e is fixedly connected to the gear 107, or alternatively integrally formed with the gear 107.
  • Introducer 107e and gear 107 are arranged coaxially with each other, wherein the gear 107 is rotatably mounted on the gear bearing 102c. In the embodiment shown, the inlet 107e and the gear 107 are directly on each other.
  • the release pin 108 connects the compression spring abutment 102g and the rack 110 by passing the release pin through the bore 110d of the rack into the bore 102h of the compression spring abutment 102g, thereby blocking expansion of the compression spring 106 (see FIGS. 13a and 13b ).
  • the pin 108 is geometrically very simple.
  • the pin could be designed as a split pin, which is guided out of the patch infusion pump 100 through the housing wall 102, so that a simple manual release of the cannula insertion mechanism by the user is made possible.
  • the release of the cannula insertion mechanism could also be the same as the basic cannula insertion mechanism of patch infusion pump 1 without departing from the inventive idea.
  • FIGS. 18 to 21 An embodiment of the cannula insertion mechanism according to the invention is shown in FIGS. 18 to 21.
  • the identifiers in this embodiment were named analogously to the basic cannula insertion mechanism of FIG. 1 shown above, the numbering was made such that z. B. the base 2a of the design of Figure 1 is analogous to the part 202a of the embodiment of Figure 18. Since the function of the embodiment of FIG. 18 is very similar to the function of the cannula insertion mechanism of FIG. 11, the differences between the mechanisms will be discussed below. For the sake of clarity, in the embodiment of FIGS. 18 to 21, no release mechanism is shown. However, it is the case that neither the release mechanism of the basic insertion mechanism ( Figures 1 to 10) or that of the preceding embodiment of the invention can be used. The means for implementing the release mechanism will be apparent to those skilled in the art based on the present disclosure.
  • FIG. 18 shows an exploded view of parts of the patch infusion device 200.
  • FIG. 19 shows a view of the parts after assembly in the initial state.
  • FIG. 20 shows the arrangement from FIG. 19 after the insertion of the infusion cannula 205a, but before the withdrawal of the insertion cannula 204a.
  • FIG. 21 shows the arrangement from FIG. 19 in the final state of the cannula insertion mechanism.
  • FIGS. 18 to 21 shows a different energy source from the previous embodiment.
  • a tension spring 206 is used to drive the cannula insertion mechanism.
  • the tension spring 206 is anchored at one end to the spring bearing 202g of the base 202a and the other end to the spring bearing 210b of the rack 210. Except for this difference in the drive, the embodiment of Figures 18 to 21 works the same as the embodiment of Figures 11 to 17th
  • FIGS. 22 to 25 An embodiment of the cannula insertion mechanism according to the invention is shown in FIGS. 22 to 25.
  • the identifiers in this embodiment were named analogously to the basic cannula insertion mechanism of FIG. 1 shown above, the numbering was made such that z. B. the base 2a of the design of Figure 1 analogous to the part 302a of the embodiment of Figure 22. Since the function of the embodiment of FIG. 22 is very similar to the function of the cannula insertion mechanism of FIG. 11, the differences between the mechanisms will be discussed below.
  • the embodiment of Figures 22 to 25 also no release mechanism is shown. However, it is such that either the release mechanism of the basic insertion mechanism (Figs. 1 to 10) or that of the embodiment of the present invention of Figs. 11 to 17 could be employed.
  • the means for implementing the release mechanism will be apparent to those skilled in the art based on the present disclosure.
  • FIG. 22 shows an exploded view of parts of the patch infusion device 300.
  • FIG. 23 shows a view of the parts after assembly in the initial state.
  • FIG. 24 shows the arrangement from FIG. 23 after the insertion of the infusion cannula 305a, but before the withdrawal of the insertion cannula 304a.
  • FIG. 25 shows the arrangement from FIG. 23 in the final state of the cannula insertion mechanism.
  • the power source for the cannula insertion mechanism is not constituted by a spring, but by the electric motor 311 which sets the gear 312 in rotation to which the rotation axis of the electric motor 311 is fixedly connected.
  • the motor is secured by suitable means to the housing 302 or base 302a (not shown in the figures).
  • the gear 312 engages the second toothing 31 Oe, which is fixedly arranged on the rack 310.
  • the rack 310 has the same function as the racks 110 and 210 of the previously described embodiments.
  • a rotation of the gear 312 is via the second toothing 31 Oe of the rack in a displacement of the rack 310 converted along the rack guide 302k, wherein the displacement of the rack 310 is converted via the toothing 310a in a rotation of the inlet wheel 307e.
  • the inlet wheel 307e is fixedly connected to the gear 307, which also rotates by the rotation of the inlet wheel.
  • rotation of the gear 307 first causes displacement of the carriage 303 in the distal direction (insertion of the infusion cannula 305a) and subsequent displacement of the carriage in the proximal direction (withdrawal of the insertion cannula 304a). Except for the different drive, the cannula insertion mechanism works in the same way as the previously described cannula insertion mechanisms of FIGS. 1 to 21.
  • FIGS. 22 to 25 An advantage of the embodiment of FIGS. 22 to 25 results from the fact that an electric motor is used as the drive.
  • the electric motor 311 can be designed so that the axis of rotation of the motor 311 is only rotatable in the idle state against a cogging torque, so there is a considerable resistance to rotation.
  • the motor 311 may be formed, for example, as a DC motor with a permanent magnet.
  • the engine is used as the drive.
  • the 311 be designed as a stepper motor and, for example, be actively held in one position. This resistance to rotation at rest may have the advantage that no actual release mechanism, as described above, must be present, and the cannula insertion mechanism via activation of the electric motor 311 can be operated.
  • Another advantage of using an electric motor can be seen in that the termination of the return movement of the carriage 303 can be done by stopping the motor, that is, the withdrawal of the insertion cannula can be stopped before the gear 307 comes into abutment with one of the sheets 303h , In this embodiment, therefore, the arc 303h could basically be omitted and the start and stop of the movement sequence of the cannula insertion mechanism as well as its initial and final position could be given by the control of the motor.
  • FIGS. 26 to 29 An embodiment of the cannula insertion mechanism according to the invention is shown in FIGS. 26 to 29.
  • the identifiers in this embodiment were named analogously to the basic cannula insertion mechanism of FIG. 1 shown above, the numbering was made such that z. B. the base 2a of the design of Figure 1 is analogous to the part 402a of the embodiment of Figure 22. Since the function of the embodiment of FIG. 2 is very similar to the function of the cannula insertion mechanism of FIG. 22, particular attention will be given below to the differences between the mechanisms.
  • no release mechanism is also shown in the embodiment of FIGS. 26 to 29. However, it is such that either the release mechanism of the basic insertion mechanism (Figs. 1 to 10) or that of the embodiment of the present invention of Figs. 11 to 17 could be employed.
  • the means for implementing the release mechanism will be apparent to those skilled in the art based on the present disclosure.
  • FIG. 26 shows an exploded view of parts of the patch infusion device 400.
  • FIG. 27 shows a view of the parts after assembly in the initial state.
  • FIG. 28 shows the arrangement of FIG. 27 after the insertion of the infusion cannula 405a, but before the withdrawal of the insertion cannula 404a.
  • FIG. 29 shows the arrangement from FIG. 27 in the final state of the cannula insertion mechanism.
  • the cannula insertion mechanism in this embodiment is driven by an electric motor.
  • the cannula insertion mechanism in patch infusion pump 400 is not driven by a rack.
  • the motor 411 mounted in the patch infusion pump 400 drives a bevel gear 412 which projects beyond its teeth (not shown) with the bevel gear Introducer 407e is coupled.
  • a motor-induced rotation of the bevel gear 412 is applied to the inlet wheel 407e and thus to the gear 407 fixed to the inlet wheel 407e, which in turn displaces the carriage 403, thereby sequentially moving the infusion cannula 405a into the tissue of the user using the insertion cannula 404a and then the insertion cannula 404 a from the tissue back into the patch infusion pump 400, analogous to the previously described embodiments and designs.
  • the bevel gear connection between parts 412 and 407e is replaced by a frictional connection.
  • the motor 411 drives in this alternative variant, a bevel gear (analogous to bevel gear 412), which is in a frictional connection to the inlet 407e, which is also formed in the alternative as Kegelreibrad.
  • the electric motor drive of the cannula insertion mechanism of the patch infusion pump 400 otherwise has the same advantages as the electric motor drive described in patch infusion pump 300.
  • the electric motors 311 and 411 of the patch infusion pumps 300 and 400, respectively, may also be used for the delivery of fluid substance in complementary embodiments. This can be done in that after the completion of the withdrawal of the insertion cannula, so after the Kanegaeninsertionsrata is completed, the coupling between the motor and Einleitrad is released, so that the engine can continue to rotate without further driving the Kanegaeninsertionsmechanismus.
  • the patch infusion pump 300 this can be done by way of example in that the toothing 310a is dimensioned so that after completion of the insertion process, the proximal end of the toothing 310 is reached.
  • bevel gear 412 and lead-in 407e may be decoupled by slightly shifting bevel gear 412 along the motor axis (not shown) of electric motor 411 from lead-in 407e.

Landscapes

  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un entraînement pour un mécanisme d'insertion destiné à un dispositif d'administration, présentant une base (102a) et une voie de guidage (102b) formée dans ou sur la base. L'entraînement comprend en outre une glissière (103) qui est prévue sur la base (102a) de manière à ne pas tourner et qui peut être déplacée le long de ou dans la voie de guidage (102b) entre des positions d'extrémité, en particulier en effectuant un va-et-vient. Un pignon menant (107) est monté de manière rotative sur la base (102a). L'entraînement comprend en outre une bande d'entraînement (103a) reliée à la glissière (103) et présentant plusieurs segments d'entraînement (103b, 103c), un premier segment d'entraînement (103b) et un second segment d'entraînement (103c) s'étendant l'un en face de l'autre ou parallèlement à la voie de guidage (102b), ainsi qu'une source d'énergie (106) au moyen de laquelle le pignon menant (107) peut être mis en rotation. Lors de la rotation du pignon menant (107), la glissière (103) se déplace dans le premier segment d'entraînement (103b) le long de ou dans la voie de guidage (102b) dans la direction distale, jusqu'à l'extrémité distale du premier segment d'entraînement (103b), le contact du pignon menant (107) passant du premier au second segment d'entraînement (103c) en continuant de faire tourner le pignon menant (107) et la glissière (103) se déplaçant par conséquent le long de ou dans la voie de guidage (102b) dans la direction proximale. La source d'énergie (106) peut être couplée au pignon menant (107) au moyen d'un élément de transmission (110) en une ou plusieurs parties et d'un pignon d'entrée (107e).
PCT/IB2018/050166 2017-01-19 2018-01-11 Mécanisme d'insertion de canules pour appareil de type patch WO2018134708A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP18701588.8A EP3570908B1 (fr) 2017-01-19 2018-01-11 Mécanisme d'insertion de canules pour appareil de type patch
US16/516,051 US11197954B2 (en) 2017-01-19 2019-07-18 Cannula insertion mechanism for a patch device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH00062/17A CH713378A2 (de) 2017-01-19 2017-01-19 Kanüleninsertionsmechanismus für ein Patch-Gerät.
CH00062/17 2017-01-19
CH00208/17A CH713403A2 (de) 2017-01-19 2017-02-23 Kanüleninsertionsmechanismus für ein Patch-Gerät.
CH00208/17 2017-02-23

Related Child Applications (1)

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US16/516,051 Continuation US11197954B2 (en) 2017-01-19 2019-07-18 Cannula insertion mechanism for a patch device

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113195016A (zh) * 2018-10-10 2021-07-30 科技医疗股份公司 用于给药装置的刺入装置
WO2021224388A1 (fr) * 2020-05-07 2021-11-11 Nemera La Verpilliere Dispositif d'insertion d'une aiguille pour la distribution d'un produit dans un site
CN114215728A (zh) * 2021-10-28 2022-03-22 武汉船用机械有限责任公司 挖泥船泵机的启停装置
CN115711321A (zh) * 2022-11-23 2023-02-24 浙江宝誉建设有限公司 水利管道施工用导向对接装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7128727B2 (en) 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
WO2013153041A2 (fr) * 2012-04-10 2013-10-17 Carebay Europe Ltd Dispositif de perfusion
US20140142508A1 (en) 2012-03-30 2014-05-22 Insulet Corporation Fluid delivery device, transcutaneous access tool and insertion mechanism for use therewith
US20150174317A1 (en) * 2013-12-19 2015-06-25 Seiko Epson Corporation Liquid transport apparatus
WO2016145094A2 (fr) * 2015-03-09 2016-09-15 Unitract Syringe Pty Ltd Mécanismes d'entraînement pour pompes d'administration de médicament

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7128727B2 (en) 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
US20140142508A1 (en) 2012-03-30 2014-05-22 Insulet Corporation Fluid delivery device, transcutaneous access tool and insertion mechanism for use therewith
WO2013153041A2 (fr) * 2012-04-10 2013-10-17 Carebay Europe Ltd Dispositif de perfusion
US20150174317A1 (en) * 2013-12-19 2015-06-25 Seiko Epson Corporation Liquid transport apparatus
WO2016145094A2 (fr) * 2015-03-09 2016-09-15 Unitract Syringe Pty Ltd Mécanismes d'entraînement pour pompes d'administration de médicament

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113195016A (zh) * 2018-10-10 2021-07-30 科技医疗股份公司 用于给药装置的刺入装置
WO2021224388A1 (fr) * 2020-05-07 2021-11-11 Nemera La Verpilliere Dispositif d'insertion d'une aiguille pour la distribution d'un produit dans un site
FR3109888A1 (fr) * 2020-05-07 2021-11-12 Nemera La Verpilliere Dispositif d’insertion d’une aiguille pour la distribution d’un produit dans un site
CN114215728A (zh) * 2021-10-28 2022-03-22 武汉船用机械有限责任公司 挖泥船泵机的启停装置
CN114215728B (zh) * 2021-10-28 2023-11-17 武汉船用机械有限责任公司 挖泥船泵机的启停装置
CN115711321A (zh) * 2022-11-23 2023-02-24 浙江宝誉建设有限公司 水利管道施工用导向对接装置
CN115711321B (zh) * 2022-11-23 2024-04-19 江山市锦弘园林建设有限公司 水利管道施工用导向对接装置

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