WO2018105755A1 - Produit cosmétique contenant des nanoparticules renfermant à l'état encapsulé un principe actif améliorant le blanchiment, et procédé de production dudit produit cosmétique - Google Patents

Produit cosmétique contenant des nanoparticules renfermant à l'état encapsulé un principe actif améliorant le blanchiment, et procédé de production dudit produit cosmétique Download PDF

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Publication number
WO2018105755A1
WO2018105755A1 PCT/KR2016/014163 KR2016014163W WO2018105755A1 WO 2018105755 A1 WO2018105755 A1 WO 2018105755A1 KR 2016014163 W KR2016014163 W KR 2016014163W WO 2018105755 A1 WO2018105755 A1 WO 2018105755A1
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Prior art keywords
whitening
weight
whitening improvement
nanoparticles
glycol
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PCT/KR2016/014163
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English (en)
Korean (ko)
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정한수
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정한수
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Priority to CN201680034087.1A priority Critical patent/CN108401417A/zh
Publication of WO2018105755A1 publication Critical patent/WO2018105755A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a cosmetic for improving skin whitening, and more particularly, to a field of cosmetics including nanoparticles that have increased solubility in water by micellizing a hydrophobic whitening improving substance.
  • Glabridine a substance that is effective in whitening and improvement in the present invention, is a fat-soluble antioxidant obtained from licorice, and shows excellent efficacy in inhibiting oxidation, inflammation, and aging of low-density lipoproteins that are harmful to the human body. It has an excellent effect on the anti-tyrosinase activity compared to other whitening ingredients known to this effect, there is an increasing number of examples of producing a functional cosmetic with a whitening effect using it.
  • glabridine or whitening improvers extracted from licorice are hydrophobic and have low solubility in water, making them difficult to apply to functional cosmetics having a whitening effect.
  • Patent Document 1 biocompatible biodegradable polymer PEG-PCL-PEG triblock copolymer
  • Patent Document 2 biocompatible biodegradable polymer PEG-PCL-PEG triblock copolymer
  • Patent Document 2 biocompatible biodegradable polymer PEG-PCL-PEG triblock copolymer
  • Efforts have been made to further include phospholipids (Patent Document 2), but the long-term stability of the biodegradable polymer PEG-PCL-PEG triblock copolymer used is poor and the composition prepared therefrom contains solvents and additives, The disadvantage is that it takes a long time to solubilize.
  • Patent Document 3 forms a complex of Gemini-type surfactant, higher alcohol, co-emulsifier, ceramide, cholesterol, etc., having two hydrophilic groups and two hydrophobic groups in one molecule, which are completely different from those of the conventional surfactant.
  • the present invention discloses a cosmetic composition in which oil-soluble licorice extract is stabilized in the interfacial multiliquid crystal, but the interfacial multiliquid crystal has a problem of poor skin penetration effect due to a large problem of particle size of about 1.0 to 3.0 ⁇ m in the shape of four petals. .
  • Patent Document 4 discloses nanoparticles in which at least one hydrophobic active ingredient is stabilized using a biodegradable polymer, but does not contain an antioxidant, so that the hydrophobic active ingredient may be oxidized and discolored over time. This is large, there is a problem in that the stability of the particles and the efficiency of skin absorption enhancement of the active ingredient is inferior.
  • the present inventors can prepare a whitening improvement active material such as licorice extract glabridine without a solvent or other additives in a simple way, and increase the solubility in water, even after a long time, whitening improvement nanoparticles excellent skin penetration While making efforts to make the composition, the whitening improvement nanoparticle composition of the present invention was confirmed to maintain a stable particle shape even after a long time, solubility and easy skin permeation completed the present invention.
  • an object of the present invention is to provide a cosmetic containing nanoparticles are sealed whitening improvement material excellent in long-term stability and skin penetration.
  • the present invention is to realize the desired object as described above,
  • whitening improvement active substance 1 part by weight of whitening improvement active substance; 1 to 30 parts by weight of a glycol solvent; 1 to 30 parts by weight of a triblock copolymer in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)]; And a skin permeation promoter 0.5 to 30 parts by weight;
  • whitening improvement active substance 1 part by weight of whitening improvement active substance; 1 to 30 parts by weight of a glycol solvent; And stirring the mixture to which 1 to 30 parts by weight of a triblock copolymer in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)] is added (step 1); And a skin permeation promoter 0.5 to 30 parts by weight to the mixture; adding and dispersing (step 2).
  • PEO polyethylene oxide
  • PPO polypropylene oxide
  • PEO polyethylene oxide
  • Cosmetics according to the present invention presented as described above can obtain the effect of improving the skin permeability of the whitening improvement active material through the nanoparticles containing the whitening improvement active material excellent in long-term stability and skin penetration.
  • FIG. 1 is a view showing a whitening improvement nanoparticles of cosmetics containing a nanoparticles containing the whitening improvement active material according to the present invention.
  • Figure 2 is a photograph of diluting the whitening improvement nanoparticles of Example 1 in water.
  • Figure 3 is a photograph of diluting the whitening improvement nanoparticles of Example 2 in water.
  • Figure 4 is a photograph of diluting the whitening improvement nanoparticles of Example 3 in water.
  • Example 5 is a photograph of diluting the whitening improvement nanoparticles of Example 4 in water.
  • Example 6 is a photograph of the discolored whitening improvement nanoparticles of Example 4 after one month.
  • Example 7 is a photograph of the discolored whitening improvement nanoparticles of Example 5 after one month.
  • Example 8 is a graph showing the size of the gloridine particle of Example 2 over time.
  • Example 9 is a graph showing the particle size distribution of Example 1 measured.
  • Example 10 is a graph showing the particle size distribution of Example 2 measured.
  • Example 11 is a graph showing the particle size distribution of Example 3 measured.
  • Example 12 is a graph showing the particle size distribution of Example 4 measured.
  • Example 13 is a graph showing the particle size distribution of Example 5 measured.
  • the present invention is 1 part by weight of whitening improvement active material
  • a cosmetic comprising a nanoparticles containing a whitening improvement active material, including; 0.5 to 30 parts by weight of a skin permeation accelerator.
  • the nanoparticles preferably have a particle size of 20 to 150 nm.
  • the whitening improvement active material is glabridin, Boswellin CG, Alma extract, Alpha lipoate, Sabi white, Sim white 377), rucinol, curcuminoids and the like can be used, with the use of glabridine or shim white.
  • the curcuminoid is preferably curcumin.
  • glycol solubilizers serve to dissolve the whitening improvement active material to micellize.
  • the glycol dissolving agent may be ethylene glycol, propylene glycol, tetraethylene glycol, polyethylene glycol, polypropylene glycol, polybutylene glycol, and the like, preferably a compound represented by the following formula (1).
  • R 1 is hydrogen or methyl
  • R 2 is hydrogen or an ester group
  • a is an integer of 1 to 200.
  • the glycol dissolving agent may be used 1 to 30 parts by weight, preferably 5 to 20 parts by weight, most preferably 10 parts by weight based on 1 part by weight of the whitening improvement active substance. If the glycol-based solubilizer is contained in an amount of less than 1 part by weight based on 1 part by weight of the whitening-improving active substance, the dispersion of the whitening-improving active substance is incomplete, which makes it difficult to release the whitening-improving active substance in future use. If it exceeds 30 parts by weight with respect to 1 part by weight of the effective active material, there is a problem that the stability of the whitening improvement active material is insufficient and the reagent is wasted.
  • glycofurol, polysorbate, cremophore, solutol HS (Solutol HS 15) and the like may be further mixed and used.
  • the triblock copolymers in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)] play a role of micelle formation and have poloxamer 184, poloxamer 185, poloxamer 188, and polox.
  • Sammer 124, Poloxamer 237, Poloxamer 338, Poloxamer 407 and the like can be used.
  • triblock copolymers are compounds represented by the following formula (2).
  • b, c and d are independently integers from 1 to 200.
  • the skin permeation promoter is preferably contained in 0.5 to 30 parts by weight based on 1 part by weight of the whitening improvement active substance. If the skin permeation accelerator is contained in an amount of less than 0.5 parts by weight based on 1 part by weight of the whitening improvement active substance, there is a problem that skin permeability is not secured, and 30 parts by weight based on 1 part by weight of the whitening improvement active substance. If it exceeds, there is a problem in that excess amount of the skin permeation accelerator required for skin permeation is contained and the reagent is wasted.
  • the antioxidant is contained in an amount of less than 0.1 part by weight based on 1 part by weight of the whitening improvement active material, there is a problem that does not prevent the oxidation of the whitening improvement active material. In this case, there is a problem that the reagent is wasted because an excess amount of the antioxidant is required to prevent oxidation of the whitening improvement active substance.
  • the present invention is a step of adding and stirring a glycol dissolving agent and a triblock copolymer in the form of [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO)] to the whitening improvement active material (step 1) ;
  • the manufacturing method according to the present invention can produce a cosmetic including nanoparticles having a particle size of 20 to 150 nm in which the whitening improvement active material is encapsulated.
  • the nanoparticles produced by the manufacturing method improve the solubility of the cosmetic containing the nanoparticles and excellent long-term stability, it is useful as a manufacturing method that can improve the applicability of the whitening improvement active material as a whitening improvement cosmetics Can be used.
  • step by step of a cosmetic manufacturing method comprising a nanoparticle encapsulated whitening improvement active material according to the present invention.
  • step 1 is a glycol dissolving agent and a [polyethylene oxide (PEO) -polypropylene oxide (PPO) -polyethylene oxide (PEO) )] Is a step of adding and stirring the triblock copolymers in the form.
  • PEO polyethylene oxide
  • PPO polypropylene oxide
  • PEO polyethylene oxide
  • the stirring temperature may be 20 to 100 °C, 40 to 80 °C is preferred.
  • step 2 is a step of dispersing by adding a skin permeation promoter.
  • the step of performing the step 1 before the step 2 may be further performed by adding an antioxidant.
  • Glavdine was prepared by purchasing a product developed by Intubio as a licorice-derived oil-soluble ingredient.
  • Sim white 377 (Phenylethyl Resorcinol) was prepared and purchased from Symrise, Germany.
  • Polyethylene glycol (PEG400) 100 mg was added to 10 mg of shim white, followed by addition of poloxamer 188 (F-68, 100 mg), a triblock copolymer, and melted at 60 ° C. to prepare a cosmetic containing liquid shim white nanoparticles. (FIG. 4).
  • PEG400 Polyethylene glycol (PEG400) (100 mg) and ⁇ -tocopherol (5 mg), antioxidants, were added to Shim White, and poloxamer 188 (F-68, 100 mg), a triblock copolymer, was melted at 60 ° C and then dissolved in liquid nano. Particles were prepared, and 100 mg of skin permeation accelerator (Brij 58) was added to the prepared whitening nanoparticle composition to prepare a cosmetic including whitening nanoparticles that are stable to oxidation reaction and promote skin permeation.
  • Brij 58 skin permeation accelerator
  • the whitening improvement nanoparticles of Examples 1 to 5 prepared above were observed with the naked eye over time after preparation, and the results are shown in Table 1, and the result was visually observed after one month to observe the discoloration over time. 6 and 7 show the results, and the particle size of the gloridine of Example 2 over time was measured and shown in FIG. 8.
  • Example 1 Example 2
  • Example 3 Example 4
  • Example 5 Sedimentation O X O X X
  • Table 1 is a table showing the precipitation of Examples 1 to 5.
  • Example 6 is a photograph of the discolored whitening improvement nanoparticles of Example 4 after one month.
  • Example 7 is a photograph of the discolored whitening improvement nanoparticles of Example 5 after one month.
  • FIG. 8 is a graph showing the particle size of the glabridine over time according to the present invention.
  • Example 4 after one month, the whitening improvement compound was oxidized and discolored. However, in Example 5, discoloration does not occur even after one month, and thus whitening improvement nanoparticles are stable to the oxidation reaction. .
  • the glabridine of the whitening improved nanoparticles according to the present invention can be seen that the long-term stability is excellent as it maintains the particle size even after 6 months.
  • the whitening improvement nanoparticles according to the present invention have excellent solubility including skin permeation accelerator, and further include an antioxidant to prevent oxidation of the whitening improvement substance, thereby improving long-term stability, and its particle size even after a long time Since it can be maintained, it can be usefully used as a cosmetic for improving whitening by containing it as an active ingredient.
  • Example 1 to 5 The particle size of Examples 1 to 5 was measured to evaluate whether the cosmetic including the whitening-improving nanoparticles according to the present invention has a size suitable for skin permeation.
  • Example One 2 3 4 5 Particle size (nm) 240.5 38.9 190.4 30.4 43.2
  • a cosmetic including the whitening-improving nanoparticles of the present invention can easily obtain the effect of permeating the skin.
  • Table 3 shows that arbutin exhibits a tyrosinase inhibitory effect of 50 to 70% even when tested with a relatively high concentration of solution, whereas glabridine and seam white nanoparticles, which are easy to penetrate the skin even with a relatively low concentration of solution, It was found that the tyrosinase was suppressed by an effect of 80% or more, which shows that the melanogenesis was excellently suppressed.
  • the whitening improvement active substance of the present invention is excellent in whitening improvement by inhibiting melanin formation, and cosmetics containing the whitening improvement nanoparticles of the present invention containing the same as an active ingredient can obtain the effect of whitening improvement.
  • the cosmetics containing the whitening improvement nanoparticles according to the present invention has a small particle size (20 to 150nm) is excellent in solubility and skin permeability, effectively oxidizing the whitening improvement compound Because it prevents the long-term stability is excellent, it can be usefully used as a whitening improvement cosmetics containing it as an active ingredient.
  • the cosmetic containing the nanoparticles containing the whitening improvement active material of the above configuration can be configured to be mixed in the cosmetic composition according to a known technique, each composition ratio can be appropriately configured according to the judgment of those skilled in the art.
  • the cosmetics according to the present invention can be used as an active ingredient of cosmetics that can be classified into a kind such as skin, toner, essence, emulsion, lotion, cream, face mist, cleansing or face pack emulsion. That is, the kind of cosmetics can be divided according to the dosage form as an active ingredient according to the present invention and may further comprise a variety of carrier components for forming each formulation.
  • the cosmetic according to the present invention is an active ingredient
  • the formulation of the cosmetic to be prepared is a paste, cream or gel
  • the carrier component is animal fiber, plant fiber, wax, paraffin, starch, trakant, cellulose derivative.
  • Polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used.
  • the carrier component is aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, already Dazolinium derivatives, methyltaurate, sarcosinate, fatty acid amide ether sulfate, alkylamidobetaine, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives or ethoxylated glycerol fatty acid esters The above can be used.
  • the carrier of this kind may be mixed with cosmetics according to the present invention (which serves as an active ingredient of the cosmetics to be manufactured) in various composition ratios, and the preferred composition ratios thereof are known according to the use of the cosmetics produced.
  • the technique can be applied as appropriate.

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Abstract

La présente invention concerne des produits cosmétiques permettant d'améliorer le blanchiment de la peau, et plus spécifiquement des produits cosmétiques contenant des nanoparticules dont la solubilité dans l'eau a été améliorée par formation de micelles dudit principe actif hydrophobe améliorant le blanchiment. Les produits cosmétiques selon la présente invention peuvent en outre présenter l'avantage d'accroître la pénétration du principe actif améliorant le blanchiment dans la peau au moyen de nanoparticules contenant à l'état encapsulé le principe actif améliorant le blanchiment, douées d'excellentes propriétés de stabilité à long terme et de pénétration dans la peau.
PCT/KR2016/014163 2016-12-05 2016-12-05 Produit cosmétique contenant des nanoparticules renfermant à l'état encapsulé un principe actif améliorant le blanchiment, et procédé de production dudit produit cosmétique WO2018105755A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201680034087.1A CN108401417A (zh) 2016-12-05 2016-12-05 包含含有美白改善有效物质的纳米粒子的化妆品及其制备方法

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KR20160164046 2016-12-05
KR10-2016-0164046 2016-12-05

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WO2018105755A1 true WO2018105755A1 (fr) 2018-06-14

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114796008A (zh) * 2022-05-31 2022-07-29 深圳市萱嘉生物科技有限公司 一种具有美白保湿功效的超分子组合物的制备方法与应用

Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
CN110200928A (zh) * 2019-07-23 2019-09-06 成秋宸 染料木素纳米冻干粉在抑制皮肤瘢痕形成和皮肤纤维化中的应用
US11554087B2 (en) 2020-11-05 2023-01-17 The Gillette Company Llc Shaving aid comprising an antioxidant
CN114306196B (zh) * 2021-12-31 2024-01-23 深圳市瑞茵电子科技有限公司 一种自组装美白活性复合物胶束的制备方法及护肤产品

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010018272A (ko) * 1999-08-18 2001-03-05 김명섭 기미, 주근깨 치료 및 미백효능성 코지산을 함유한 친수성 외용겔제
KR20020060054A (ko) * 2000-12-21 2002-07-16 차알스 제이. 메츠 신체 보호용 조성물
KR20100125278A (ko) * 2008-02-01 2010-11-30 암콜 인터내셔널 코포레이션 향상된 피부 미백 조성물
KR20120022368A (ko) * 2010-09-02 2012-03-12 대화제약 주식회사 에스-시탈로프람의 경피흡수제형
CN103385806B (zh) * 2013-08-08 2015-08-12 珀莱雅化妆品股份有限公司 一种抑制美白化妆品变黄的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017002438A (es) * 2014-08-27 2017-05-23 Abbvie Inc Formulacion topica.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010018272A (ko) * 1999-08-18 2001-03-05 김명섭 기미, 주근깨 치료 및 미백효능성 코지산을 함유한 친수성 외용겔제
KR20020060054A (ko) * 2000-12-21 2002-07-16 차알스 제이. 메츠 신체 보호용 조성물
KR20100125278A (ko) * 2008-02-01 2010-11-30 암콜 인터내셔널 코포레이션 향상된 피부 미백 조성물
KR20120022368A (ko) * 2010-09-02 2012-03-12 대화제약 주식회사 에스-시탈로프람의 경피흡수제형
CN103385806B (zh) * 2013-08-08 2015-08-12 珀莱雅化妆品股份有限公司 一种抑制美白化妆品变黄的方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114796008A (zh) * 2022-05-31 2022-07-29 深圳市萱嘉生物科技有限公司 一种具有美白保湿功效的超分子组合物的制备方法与应用

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