WO2018090329A1 - 一种具有功能化的柔性电极及其制备方法 - Google Patents

一种具有功能化的柔性电极及其制备方法 Download PDF

Info

Publication number
WO2018090329A1
WO2018090329A1 PCT/CN2016/106428 CN2016106428W WO2018090329A1 WO 2018090329 A1 WO2018090329 A1 WO 2018090329A1 CN 2016106428 W CN2016106428 W CN 2016106428W WO 2018090329 A1 WO2018090329 A1 WO 2018090329A1
Authority
WO
WIPO (PCT)
Prior art keywords
functionalized
flexible electrode
nano
flexible
flexible substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2016/106428
Other languages
English (en)
French (fr)
Inventor
杜学敏
崔欢庆
王娟
吴天准
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Institute of Advanced Technology of CAS
Original Assignee
Shenzhen Institute of Advanced Technology of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Institute of Advanced Technology of CAS filed Critical Shenzhen Institute of Advanced Technology of CAS
Priority to PCT/CN2016/106428 priority Critical patent/WO2018090329A1/zh
Publication of WO2018090329A1 publication Critical patent/WO2018090329A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B5/00—Non-insulated conductors or conductive bodies characterised by their form
    • H01B5/14—Non-insulated conductors or conductive bodies characterised by their form comprising conductive layers or films on insulating-supports

Definitions

  • the invention relates to a flexible electrode, in particular to a flexible electrode with functionalization and a preparation method thereof.
  • implantable devices such as implantable medical devices
  • flexible electrodes because most of the human tissues are rugged or even have a certain curvature, such as the retina, cochlea, brain, etc.
  • Good adhesion to the stimulation site directly affects the effectiveness of the implanted device (Survey of Ophthalmology, 2002, 47, 335-356).
  • implantable devices in the event of malfunction and danger, they can only be removed by surgery, which can cause greater trauma to the patient. What's more, some implanted devices, such as artificial retinas, combine with human tissue after implantation, so they are not easily replaceable.
  • the shape change of the flexible electrode was achieved by pressure-induced deformation in an annealed manner, but it was easy to damage expensive electrodes (Survey of Ophthalmology, 2002, 47, 335-356).
  • Recently, Harvard University's Charles M. Lieber team developed an injectable metal mesh electrode that automatically unfolds when injected into a living body.
  • the electrode deployment is based solely on the release of stress in the metal mesh electrode, which may result in Tissue damage (Nature Nanotechnology, 2015, 10, 629-636), and the entire metal network can only be used as a single stimulus or information acquisition unit, unable to achieve multi-channel stimulation or information collection.
  • the present invention is directed to a functionalized flexible electrode and a method of making the same.
  • the functionalized flexible electrode can be realized by stimulation of temperature, humidity, light, etc., has good practicability and wide adaptability, and can be widely applied in the fields of aviation, aerospace, medicine and bioengineering.
  • a flexible electrode having a flexible substrate, the flexible substrate comprising a flexible material, one side of the flexible substrate is provided with an electrode material, and the other side of the flexible substrate is functionalized material.
  • the functionalized material has a thickness of from 0.01 ⁇ m to 2 cm. Further preferably, the functionalized material has a thickness of from 0.1 ⁇ m to 800 ⁇ m. The thickness selection of the functionalized material allows for adjustment of the functionalized flexible electrode response time.
  • the functionalized material has a molecular weight of from 100 to 70 million. Further preferably, the functionalized material has a molecular weight of from 100 to 10 million. The molecular weight of the functionalized material is selected to achieve mechanical properties adjustment of the functionalized flexible electrode responsive material.
  • the functionalized material comprises at least one of a temperature sensitive material, a humidity sensitive material, and a light sensitive material.
  • the temperature sensitive material comprises ethylene oxide, polyvinyl methyl ether, polyhydroxypropyl acrylate, polyethylene glycol, derivatives of polyethylene glycol, poly-N substituted acrylamide, and elastic-like Protein polypeptide, styrene-butadiene copolymer, trans-polyisoprene, ethylene-vinyl acetate copolymer, polynorbornene, polyurethane (PU), epoxy resin (EP), ethylene-vinyl acetate copolymerization (EVA), polyimide (PI), cellulose, polycaprolactone (PCL), polylactic acid (PLA), polyglycolic acid (PGA), polylactic acid-glycolic acid copolymer (PLGA), polyethylene At least one of alcohol (PVA) polymers;
  • the moisture sensitive material comprises at least one of silk protein, spider silk, hydrogel;
  • the light sensitive material comprises cinnamyl, azo, triphenylmethane, two At least one of the st
  • the functionalized material further comprises a functional conversion material.
  • the weight of the functionalized conversion material is from 0.001% to 50% by weight of the functionalized material. , further preferably 0.01% to 30%.
  • the functional conversion material includes at least one of an inorganic photothermal conversion material, an organic photothermal conversion material, an organic electrothermal conversion material, and a magnetothermal conversion material.
  • the inorganic photothermal conversion material comprises one or more of nano gold, nano silver, nano copper, nano platinum, nano palladium, nano bismuth, carbon nanotube, black phosphorus and graphene, or surface functionalization One or more of nano gold, nano silver, nano copper, nano platinum, nano palladium, nano bismuth, carbon nanotube, carbon black, black phosphorus and graphene, or nano gold, nano silver, nano copper, nano One or more of a composite material of platinum, nanopalladium, nano cerium, carbon nanotube, carbon black, black phosphorus, graphene; the organic photothermal conversion material comprises polypyrrole, polyaniline, polyethylene dioxythiophene One or more of polystyrene sulfonate, phthalocyanine green, porphyrin liposome, and modified materials thereof; magnetocaloric conversion materials include Fe 2 O 3 , Fe 3 O 4 , FeCo, One or more of NiFe, CoFeO, NiFeO, MnFeO,
  • the flexible substrate is at least one of a plastic, a rubber, a hydrogel, and a composite thereof.
  • the plastic comprises one or more of polyimide (PI), parylene, polylactic acid, polyglycolic acid, polylactic acid-glycolic acid copolymer, and composite materials thereof;
  • the rubber includes one or more of polydimethylsiloxane (PDMS), silica gel, and a composite thereof;
  • the hydrogel includes polyethylene glycol, polyvinyl alcohol, chitosan, alginic acid One or more of sodium, agarose, cellulose, silk fibroin, nucleic acids, polypeptides, and composites thereof.
  • the present invention provides a method for preparing a functionalized flexible electrode as described above, comprising the steps of:
  • the manner of curing in the step (2) comprises photocuring, heat curing, radiation curing or chemical crosslinking.
  • the functionalized material is grafted to the surface of the flexible substrate by chemical crosslinking.
  • the functional material is grafted to the surface of the flexible substrate by chemical crosslinking, and the surface of the flexible substrate needs to be chemically modified to be attached to at least one of a carbon-carbon double bond, an amino group, a carboxyl group, a hydroxyl group and a thiol group.
  • the functional material is then grafted to the surface of the flexible substrate by chemical crosslinking by irradiation polymerization, thermal polymerization, photoinitiated polymerization.
  • the functional material is applied to the surface of the flexible substrate by casting, spin coating, knife coating, spraying, etc., and then cured on the surface of the flexible substrate.
  • the invention designs a plurality of functionalized polymer materials to the surface of the flexible electrode substrate, and by compounding with the functional micro-nano material, the flexible electrode shape adaptive change function can be realized under the stimulation of temperature, humidity and light.
  • the method for preparing the functionalized flexible electrode is diversified, and the composite material can also be applied to the substrate of the flexible electrode to realize the functionalization of the flexible electrode.
  • the functional adaptability of the functionalized flexible electrode can be remotely adjusted, and the functionalized flexible electrode can be extended in the fields of medical and bioengineering such as wearing and implanting.
  • the invention realizes the functionalization of the wearable and implantable electrodes, has various preparation methods, high reliability and good safety, and expands the application field of the intelligent polymer materials.
  • the functionalized flexible electrode can realize shape change by temperature, humidity, light and other stimuli, and the method is diversified, and the control is convenient, which lays a solid foundation for the application of the functionalized flexible electrode in the field of wearable and implantable medical treatment.
  • the functionalized flexible electrode of the invention can adapt the shape to match the living tissue, and solves the problems that the existing flexible electrode can not effectively match the living tissue and affect the electrophysiological stimulation and signal acquisition. Improve the reliability and effectiveness of functionalized flexible electrodes in the field of wearable and implantable medical applications.
  • Embodiment 1 is a shape-adjustable flexible electrode according to Embodiment 1 of the present invention.
  • FIG. 2 is a functional diagram of a shape-adjustable flexible electrode of the real-time example 2 of the present invention.
  • the flexible electrode comprises a flexible substrate, the flexible substrate is made of polydimethylsiloxane, and one side of the flexible substrate is provided with an electrode material. The other side of the flexible substrate is provided with a functionalized material.
  • the preparation method of the functionalized flexible electrode comprises the following steps:
  • the poly-N-isopropylacrylamide hydrogel with temperature-sensitive properties grafted onto the flexible substrate surface of the PI flexible electrode by grafting method can realize the shape change of the PI substrate flexible electrode under human body temperature, as shown in Fig. 1. It is shown that the left side of Fig. 1 is before the deformation of the flexible electrode, and the right side is after the deformation of the flexible electrode.
  • the flexible electrode comprises a flexible substrate, the flexible substrate is made of parylene, and one side of the flexible substrate is provided with an electrode material, the flexibility The other side of the substrate is provided with a functionalized material.
  • the preparation method of the functionalized flexible electrode comprises the following steps:
  • the flexible electrode based on parylene was used as a spinning voltage of 20KV between the receiving devices, the spinning distance between the spinning needle and the receiving aluminum foil was controlled to be 13 cm, and the flow rate of the electrospinning solution was adjusted to 0.01 mL/min.
  • the wire needle has an inner diameter of 0.9 mm, a spinning temperature of 25 ° C, and an air humidity of 53%.
  • a functionalized flexible electrode having a shape memory effect is produced by an electrospinning technique.
  • the flexible electrode coated with polycaprolactone (PCL) on the surface of the flexible substrate can be shaped and curled in vitro, and the body temperature is triggered to realize the self-expanding function after the implant, as shown in FIG. 2, the shape is fixed on the left side in FIG.
  • the middle is the electrode when unfolded
  • the right is the front view of the flexible electrode after unfolding.
  • the flexible electrode comprises a flexible substrate, the material of the flexible substrate is polyimide, and one side of the flexible substrate is provided with an electrode material, the flexibility The other side of the substrate is provided with a functionalized material.
  • the preparation method of the functionalized flexible electrode comprises the following steps:
  • the shape memory function of the flexible electrode is realized, and the flexible electrode is specifically shaped, and the shape recovery of the flexible electrode can be realized by near-infrared illumination. .

Landscapes

  • Materials For Medical Uses (AREA)

Abstract

一种具有功能化的柔性电极，所述柔性电极包括柔性基底，所述柔性基底的一面设有电极材料，所述柔性基底的另一面设有功能化材料。所述功能化柔性电极的制备方法多样化，可通过温度、湿度、光等刺激实现形状改变，方式多样化，而且操控便利，为功能化柔性电极在穿戴、植入式医疗领域应用奠定了坚实的基础。

Description

一种具有功能化的柔性电极及其制备方法 技术领域
本发明涉及一种柔性电极，具体涉及一种具有功能化的柔性电极及其制备方法。
背景技术
近年来，随着老龄化的加剧，听力、视力等各种慢性疾病的发病率越来越高，特别是在中国，作为一个老龄化日益加重的国家，目前老龄化人口已达到2个亿，由此带来的社会、家庭等问题将日益严重。值得庆幸的是，在过去30年，穿戴、植入医疗器械产业迅速发展，且取得了令人瞩目的成果：从穿戴式的心电、脑电监测装置，到植入式心脏起搏器、人工耳蜗、人工视网膜、各种植入性电极(用于帕金森病、癫痫等疾病的治疗)等。相关产品在解决听力、视力障碍等问题方面卓有成效，相关产品也已广为推广。然而，这类穿戴、植入式的器件都存在同样一个问题：形状适应匹配。以植入式设备为例，如植入式的医疗器械，由于大部分人体组织都是凹凸不平，甚至是有一定弧度的，如视网膜、耳蜗、脑等，植入刺激用的柔性电极能否很好贴合刺激部位，直接影响着植入式器件的有效性(Survey of Ophthalmology,2002,47,335-356)。特别对于这些可植入设备，一旦出现故障和危险，只能通过手术取出更换，从而会给患者造成较大的创伤。更何况，一些植入设备，例如人工视网膜，植入后会和人体组织结合在一起，所以是不易更换的。
早期，柔性电极形状改变是通过退火的方式压致变形实现，但容易损坏价格昂贵的电极(Survey of Ophthalmology,2002,47,335-356)。最近，哈佛大学Charles M.Lieber课题组开发出了一种可注射金属网状电极，注入活体后会自动展开，然而电极的展开也仅仅是基于金属网状电极内应力的释放，由此可能导致组织损伤(Nature Nanotechnology,2015,10,629-636)，而且整个金属网络也仅仅只能作为单个刺激或信息采集单元，无法实现多通道刺激或信息采集功能。
近些年来，随着穿戴、植入式医疗器械的开发及应用在世界范围广受关注， 随着我国对生物自主研发的穿戴、植入式医疗器械及其产业化的重视，伴随着广大医生及患者对相关技术产品的迫切需求，研制拥有自主知识产权的功能化柔性电极势在必行。
发明内容
鉴于此，本发明旨在提供一种具有功能化的柔性电极及其制备方法。该功能化柔性电极可以通过温度、湿度、光等刺激实现，实用性好，适应性广，可在航空、航天、医学及生物工程领域普遍应用。
为实现上述目的，所采取的技术方案：一种具有功能化的柔性电极，所述柔性电极包括柔性基底，所述柔性基底的一面设有电极材料，所述柔性基底的另一面设有功能化材料。
优选地，所述功能化材料的厚度为0.01μm～2cm。进一步优选地，所述功能化材料的厚度为0.1μm～800μm。功能化材料的厚度选择可以实现功能化柔性电极响应时间的调节。
优选地，所述功能化材料的分子量为100～7000万。进一步优选地，所述功能化材料的分子量为100～1000万。功能化材料分子量的选择是为了实现功能化柔性电极响应性材料的力学性能调节。
优选地，所述功能化材料包括温敏材料、湿度敏感材料、光敏感材料中的至少一种。
优选地，所述的温敏材料包括环氧乙烷、聚乙烯基甲醚、聚羟丙基丙烯酸酯、聚乙二醇、聚乙二醇的衍生物、聚-N取代丙烯酰胺、类弹性蛋白多肽、苯乙烯-丁二烯共聚物、反式聚异戊二烯、乙烯-醋酸乙烯共聚物、聚降冰片烯、聚氨酯(PU)、环氧树脂(EP)、乙烯-醋酸乙烯酯共聚物(EVA)、聚酰亚胺(PI)、纤维素、聚己内酯(PCL)、聚乳酸(PLA)、聚乙醇酸(PGA)、聚乳酸-羟基乙酸共聚物(PLGA)、聚乙烯醇(PVA)聚合物中的至少一种；所述湿度敏感材料包括蚕丝蛋白、蜘蛛丝、水凝胶中的至少一种；所述光敏感材料包括肉桂基、偶氮、三苯甲烷、二苯乙烯基团中的至少一种。
优选地，所述功能化材料还包括功能转换材料。
优选地，所述功能化转换材料的重量是所述功能化材料重量的0.001％～50％。，进一步优选地0.01％～30％.
优选地，所述功能转换材料包括无机光热转换材料、有机光热转换材料、有机电热转换材料和磁致热转换材料中的至少一种。
优选地，所述无机光热转换材料包括纳米金、纳米银、纳米铜、纳米铂、纳米钯、纳米锗、碳纳米管、黑磷和石墨烯中的一种或多种，或表面功能化的纳米金、纳米银、纳米铜、纳米铂、纳米钯、纳米锗、碳纳米管、炭黑、黑磷和石墨烯中的一种或多种，或纳米金、纳米银、纳米铜、纳米铂、纳米钯、纳米锗、碳纳米管、炭黑、黑磷、石墨烯的复合材料中的一种或多种；所述有机光热转换材料包括聚吡咯、聚苯胺、聚乙烯二氧噻吩、聚苯乙烯磺酸盐、吲哚菁绿、卟啉脂质体以及它们的改性材料中的一种或多种；磁致热转换材料包括Fe2O3、Fe3O4、FeCo、NiFe、CoFeO、NiFeO、MnFeO以及它们的复合材料中的一种或多种。
优选地，所述柔性基底为塑料、橡胶、水凝胶以及它们的复合材料中的至少一种。
优选地，所述塑料包括聚酰亚胺(PI)、聚对二甲苯(Parylene)、聚乳酸、聚乙醇酸、聚乳酸-羟基乙酸共聚物以及它们的复合材料中的一种或多种；所述橡胶包括聚二甲基硅氧烷(PDMS)、硅胶以及它们的复合材料中的一种或多种；所述水凝胶包括聚乙二醇、聚乙烯醇、壳聚糖、海藻酸钠、琼脂糖、纤维素、蚕丝蛋白、核酸、多肽以及它们的复合材料中的一种或多种。
本发明提供了一种上述所述的具有功能化的柔性电极的制备方法，包括以下步骤：
(1)提供具有柔性基底的柔性电极；
(2)将功能化材料固化到所述柔性电极的柔性基底表面。
优选地，所述步骤(2)中固化的方式包括光固化、热固化、辐照固化或化学交联。
优选地，所述功能化材料通过化学交联方式接枝到柔性基底表面。具体地，将所述的功能性材料通过化学交联方式接枝到柔性基底表面，需要先对柔性基底表面进行化学修饰接上碳碳双键、氨基、羧基、羟基和巯基中的至少一种，然后通过辐照聚合、热聚合、光引发聚合发生化学交联将功能性材料接枝到柔性基底表面。
优选地，所述的功能性材料通过浇注、旋涂、刮涂、喷涂等方式涂覆到柔性基底表面，然后在柔性基底表面固化。
本发明将多种功能化聚合物材料设计到柔性电极基底表面，通过与功能微纳材料的复合，可在温度、湿度、光的刺激下实现柔性电极形状适应性改变功能。该功能化柔性电极的制备方法多样化，同时还可将复合材料涂覆到柔性电极的基底上，实现柔性电极的功能化。另外，结合功能转换材料，可远程调节功能化柔性电极形状适应性改变，拓展功能化柔性电极在穿戴、植入等医疗及生物工程等领域应用。
本发明的有益效果在于：
1、本发明实现了穿戴、植入式电极的功能化，制备方法多样化，而且可靠性高、安全性好，拓展了智能高分子材料的应用领域。
2、该功能化柔性电极可通过温度、湿度、光等刺激实现形状改变，方式多样化，而且操控便利，为功能化柔性电极在穿戴、植入式医疗领域应用奠定了坚实的基础。
本发明功能化柔性电极可适应性改变形状以匹配生物体组织，解决了现有柔性电极无法有效匹配生物体组织而影响电生理刺激和信号采集等问题。提升了功能化柔性电极在穿戴、植入式医疗领域应用的可靠性、有效性。
附图说明
图1为本发明实施例1的形状可调柔性电极；
图2为本发明实时例2形状可调柔性电极功能图。
具体实施方式
为更好的说明本发明的目的、技术方案和优点，下面将结合具体实施例对本发明作进一步说明。
实施例1
本发明所述具有功能化的柔性电极的一种实施例，所述柔性电极包括柔性基底，所述柔性基底的材料为聚二甲基硅氧烷，所述柔性基底的一面设有电极材料，所述柔性基底的另一面设有功能化材料。所述具有功能化的柔性电极的制备方法包括以下步骤：
(1)提供具有聚二甲基硅氧烷基底的柔性电极；
(2)将聚酰亚胺(PI)基底表面通过等离子体(plasma)处理后，将其置于乙烯基三氯硅烷的氛围中，利用化学气相沉积法在聚酰亚胺基底表面沉积接枝上双键；将0.5g N-异丙基丙烯酰胺、0.005g N,N-二甲基丙烯酰胺，10μL紫外光引发剂二烷氧基苯乙酮，和1mL水混合后超声分散，利用特定模具将其注入到修饰好双键的PI基底表面紫外光下聚合30min取出，置于超纯水中浸泡48h。
利用接枝法在PI柔性电极的柔性基底表面接枝上具有温敏性质的聚N-异丙基丙烯酰胺水凝胶，可实现PI基底柔性电极在人体体温下实现形状改变，如图1所示，图1中左边为柔性电极形变前，右边为柔性电极形变后。
实施例2
本发明所述具有功能化的柔性电极的一种实施例，所述柔性电极包括柔性基底，所述柔性基底的材料为聚对二甲苯，所述柔性基底的一面设有电极材料，所述柔性基底的另一面设有功能化材料。所述具有功能化的柔性电极的制备方法包括以下步骤：
(1)提供具有聚对二甲苯基底的柔性电极；
(2)将3g聚乙醇酸加入到20g的二甲基酰胺(DMF)中，机械搅拌至溶液透明得到静电纺丝溶液；将制得的纺丝溶液装入储液装置，在纺丝针头和以聚对二甲苯为基底的柔性电极作为接收装置间施加20KV的纺丝电压，控制纺丝针头与接收铝箔间的纺丝距离为13cm，调节静电纺丝溶液的流速为0.01mL/min，纺丝针头内径为0.9mm，纺丝温度为25℃，空气湿度为53％。通过静电纺丝技术制得具有形状记忆效应的功能化柔性电极。
柔性基底表面涂覆有聚己内酯(PCL)的柔性电极可在体外塑形卷曲，在植入体后利用人体体温触发实现自展开功能，如图2所示，图2中左边为形状固定柔性电极，中为展开时电极，右为展开后柔性电极正面图。
实施例3
本发明所述具有功能化的柔性电极的一种实施例，所述柔性电极包括柔性基底，所述柔性基底的材料为聚酰亚胺，所述柔性基底的一面设有电极材料，所述柔性基底的另一面设有功能化材料。所述具有功能化的柔性电极的制备方法包括以下步骤：
(1)提供具有聚酰亚胺基底的柔性电极；
(2)将3g聚乳酸、0.5g聚乙二醇、0.2g金纳米颗粒加入到烧杯中，于160℃下加热至熔融状态且混合均匀，将熔融液倒入特定模具，模具的底部为柔性电极的聚酰亚胺(PI)基底表面，即获得具有形状记忆效应的功能化柔性电极。
通过将PLA涂覆到柔性电极的柔性基底表面(玻璃化转变温度为42℃)，实现柔性电极的形状记忆功能，将柔性电极进行特定的塑形，可通过近红外光照实现柔性电极的形状恢复。
最后所应当说明的是，以上实施例仅用以说明本发明的技术方案而非对本发明保护范围的限制，尽管参照较佳实施例对本发明作了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的实质和范围。

Claims (14)

  1. 一种具有功能化的柔性电极，其特征在于，所述柔性电极包括柔性基底，所述柔性基底的一面设有电极材料，所述柔性基底的另一面设有功能化材料。
  2. 根据权利要求1所述的具有功能化的柔性电极，其特征在于，所述功能化材料的厚度为0.1μm～1cm。
  3. 根据权利要求1所述的具有功能化的柔性电极，其特征在于，所述功能化材料的厚度为0.1μm～8 00μm。
  4. 根据权利要求1所述的具有功能化的柔性电极，其特征在于，所述功能化材料的分子量为100～7000万。
  5. 根据权利要求1所述的具有功能化的柔性电极，其特征在于，所述功能化材料的分子量为100～1000万。
  6. 根据权利要求1所述的具有功能化的柔性电极，其特征在于，所述功能化材料包括温敏材料、湿度敏感材料、光敏感材料中的至少一种。
  7. 根据权利要求6所述的具有功能化的柔性电极，其特征在于，所述的温敏材料包括环氧乙烷、聚乙烯基甲醚、聚羟丙基丙烯酸酯、聚乙二醇、聚乙二醇的衍生物、聚-N取代丙烯酰胺、类弹性蛋白多肽、苯乙烯-丁二烯共聚物、反式聚异戊二烯、乙烯-醋酸乙烯共聚物、聚降冰片烯、聚氨酯、环氧树脂、乙烯-醋酸乙烯酯共聚物、聚酰亚胺、纤维素、聚己内酯、聚乳酸、聚乙醇酸、聚乳酸-羟基乙酸共聚物、聚乙烯醇聚合物中的至少一种；所述湿度敏感材料包括蚕丝蛋白、蜘蛛丝、水凝胶中的至少一种；所述光敏感材料包括肉桂基、偶氮、三苯甲烷、二苯乙烯基团中的至少一种。
  8. 根据权利要求6所述的具有功能化的柔性电极，其特征在于，所述功能化材料还包括功能转换材料。
  9. 根据权利要求8所述的具有功能化的柔性电极，其特征在于，所述功能转换材料包括无机光热转换材料、有机光热转换材料、有机电热转换材料和磁致热转换材料中的至少一种。
  10. 根据权利要求9所述的具有功能化的柔性电极，其特征在于，所述无 机光热转换材料包括纳米金、纳米银、纳米铜、纳米铂、纳米钯、纳米锗、碳纳米管、黑磷和石墨烯中的一种或多种，或表面功能化的纳米金、纳米银、纳米铜、纳米铂、纳米钯、纳米锗、碳纳米管、炭黑、黑磷和石墨烯中的一种或多种，或纳米金、纳米银、纳米铜、纳米铂、纳米钯、纳米锗、碳纳米管、炭黑、黑磷、石墨烯的复合材料中的一种或多种；所述有机光热转换材料包括聚吡咯、聚苯胺、聚乙烯二氧噻吩、聚苯乙烯磺酸盐、吲哚菁绿、卟啉脂质体以及它们的改性材料中的一种或多种；磁致热转换材料包括Fe2O3、Fe3O4、FeCo、NiFe、CoFeO、NiFeO、MnFeO以及它们的复合材料中的一种或多种。
  11. 根据权利要求1所述的具有功能化的柔性电极，其特征在于，所述柔性基底为塑料、橡胶、水凝胶以及它们的复合材料中的至少一种。
  12. 根据权利要求11所述的具有功能化的柔性电极，其特征在于，所述塑料包括聚酰亚胺、聚对二甲苯、聚乳酸、聚乙醇酸、聚乳酸-羟基乙酸共聚物以及它们的复合材料中的一种或多种；所述橡胶包括聚二甲基硅氧烷、硅胶以及它们的复合材料中的一种或多种；所述水凝胶包括聚乙二醇、聚乙烯醇、壳聚糖、海藻酸钠、琼脂糖、纤维素、蚕丝蛋白、核酸、多肽以及它们的复合材料中的一种或多种。
  13. 一种如权利要求1-12任一所述的具有功能化的柔性电极的制备方法，其特征在于，包括以下步骤：
    (1)提供具有柔性基底的柔性电极；
    (2)将功能化材料固化到所述柔性电极的柔性基底表面。
  14. 根据权利要求13所述的制备方法，其特征在于，所述步骤(2)中固化的方式包括光固化、热固化、辐照固化或化学交联。
PCT/CN2016/106428 2016-11-18 2016-11-18 一种具有功能化的柔性电极及其制备方法 Ceased WO2018090329A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/106428 WO2018090329A1 (zh) 2016-11-18 2016-11-18 一种具有功能化的柔性电极及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/106428 WO2018090329A1 (zh) 2016-11-18 2016-11-18 一种具有功能化的柔性电极及其制备方法

Publications (1)

Publication Number Publication Date
WO2018090329A1 true WO2018090329A1 (zh) 2018-05-24

Family

ID=62146030

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2016/106428 Ceased WO2018090329A1 (zh) 2016-11-18 2016-11-18 一种具有功能化的柔性电极及其制备方法

Country Status (1)

Country Link
WO (1) WO2018090329A1 (zh)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109082742A (zh) * 2018-09-10 2018-12-25 武汉纺织大学 对光热和湿度具有刺激响应性的纤维基扭转驱动器及其制备方法与应用
CN110028511A (zh) * 2019-03-25 2019-07-19 华东理工大学 一种使用新型不对称含氟锌酞菁重氮盐通过共价修饰对黑磷进行化学保护的方法
CN110412487A (zh) * 2019-07-31 2019-11-05 电子科技大学 一种织物型柔性复合式传感器及其制作方法
CN110511411A (zh) * 2019-09-04 2019-11-29 电子科技大学 一种温度敏感的柔性膜、传感器及柔性膜的制备方法
CN111540916A (zh) * 2020-05-13 2020-08-14 辽宁大学 温敏型导电智能水凝胶微球修饰的碳毡电极材料及其制备方法和应用
CN112185606A (zh) * 2020-09-29 2021-01-05 梁燕 一种高分子柔性导电薄膜及其制备方法
CN112471173A (zh) * 2020-11-26 2021-03-12 中国科学院合肥物质科学研究院 石墨烯抗菌复合膜的制备方法、制得的抗菌复合膜
CN112587140A (zh) * 2020-12-09 2021-04-02 清华大学深圳国际研究生院 一种自贴附仿生章鱼吸盘微纳结构干电极
CN112939128A (zh) * 2020-12-02 2021-06-11 西安交通大学 一种具有高集热效应海水淡化气凝胶的制备方法
CN112980203A (zh) * 2021-02-18 2021-06-18 重庆大学 一种柔性超声衰减膜及其应用
CN113073463A (zh) * 2021-03-15 2021-07-06 浙江理工大学 一种可用于人体温度信号实时监测的蚕丝基柔性传感器的制备方法
WO2021203615A1 (zh) * 2020-04-09 2021-10-14 国家纳米科学中心 一种复合神经电极及其制备方法
CN113631511A (zh) * 2019-03-06 2021-11-09 罗伯特·博世有限公司 磁制冷模块及其制备方法
CN114605674A (zh) * 2022-04-22 2022-06-10 福州大学 一种高比电容聚苯胺复合柔性导电水凝胶及其制备方法
CN116217975A (zh) * 2023-03-21 2023-06-06 福建工程学院 一种有机无机杂化双导电网络聚乙烯醇复合水凝胶的制备方法
CN116295968A (zh) * 2023-02-27 2023-06-23 昆明理工大学 一种柔性压力传感器及其制备与应用
CN117224126A (zh) * 2022-06-06 2023-12-15 中国科学院上海硅酸盐研究所 一种柔性生物电干电极及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110250718A1 (en) * 2010-04-09 2011-10-13 Yueh-Lin Loo Lamination as a modular approach for building organic photosensitive devices
CN104257356A (zh) * 2014-09-16 2015-01-07 苏州能斯达电子科技有限公司 一种柔性温敏传感器及基于该传感器的体温监测系统
CN105067016A (zh) * 2015-08-19 2015-11-18 东南大学 基于氧化石墨烯的柔性集成温湿度传感器及其制备方法
CN106092203A (zh) * 2016-07-26 2016-11-09 华南师范大学 一种多功能传感器设备及其制备方法
CN106601338A (zh) * 2016-11-18 2017-04-26 中国科学院深圳先进技术研究院 一种具有功能化的柔性电极及其制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110250718A1 (en) * 2010-04-09 2011-10-13 Yueh-Lin Loo Lamination as a modular approach for building organic photosensitive devices
CN104257356A (zh) * 2014-09-16 2015-01-07 苏州能斯达电子科技有限公司 一种柔性温敏传感器及基于该传感器的体温监测系统
CN105067016A (zh) * 2015-08-19 2015-11-18 东南大学 基于氧化石墨烯的柔性集成温湿度传感器及其制备方法
CN106092203A (zh) * 2016-07-26 2016-11-09 华南师范大学 一种多功能传感器设备及其制备方法
CN106601338A (zh) * 2016-11-18 2017-04-26 中国科学院深圳先进技术研究院 一种具有功能化的柔性电极及其制备方法

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109082742A (zh) * 2018-09-10 2018-12-25 武汉纺织大学 对光热和湿度具有刺激响应性的纤维基扭转驱动器及其制备方法与应用
CN113631511B (zh) * 2019-03-06 2023-11-24 罗伯特·博世有限公司 磁制冷模块及其制备方法
CN113631511A (zh) * 2019-03-06 2021-11-09 罗伯特·博世有限公司 磁制冷模块及其制备方法
CN110028511A (zh) * 2019-03-25 2019-07-19 华东理工大学 一种使用新型不对称含氟锌酞菁重氮盐通过共价修饰对黑磷进行化学保护的方法
CN110028511B (zh) * 2019-03-25 2021-07-06 华东理工大学 一种使用不对称含氟锌酞菁重氮盐通过共价修饰对黑磷进行化学保护的方法
CN110412487B (zh) * 2019-07-31 2021-04-20 电子科技大学 一种织物型柔性复合式传感器及其制作方法
CN110412487A (zh) * 2019-07-31 2019-11-05 电子科技大学 一种织物型柔性复合式传感器及其制作方法
CN110511411B (zh) * 2019-09-04 2021-02-26 电子科技大学 一种温度敏感的柔性膜、传感器及柔性膜的制备方法
CN110511411A (zh) * 2019-09-04 2019-11-29 电子科技大学 一种温度敏感的柔性膜、传感器及柔性膜的制备方法
WO2021203615A1 (zh) * 2020-04-09 2021-10-14 国家纳米科学中心 一种复合神经电极及其制备方法
CN111540916A (zh) * 2020-05-13 2020-08-14 辽宁大学 温敏型导电智能水凝胶微球修饰的碳毡电极材料及其制备方法和应用
CN112185606B (zh) * 2020-09-29 2022-04-01 深圳市法鑫忠信新材料有限公司 一种高分子柔性导电薄膜及其制备方法
CN112185606A (zh) * 2020-09-29 2021-01-05 梁燕 一种高分子柔性导电薄膜及其制备方法
CN112471173B (zh) * 2020-11-26 2022-02-11 中国科学院合肥物质科学研究院 石墨烯抗菌复合膜的制备方法、制得的抗菌复合膜
CN112471173A (zh) * 2020-11-26 2021-03-12 中国科学院合肥物质科学研究院 石墨烯抗菌复合膜的制备方法、制得的抗菌复合膜
CN112939128A (zh) * 2020-12-02 2021-06-11 西安交通大学 一种具有高集热效应海水淡化气凝胶的制备方法
CN112587140A (zh) * 2020-12-09 2021-04-02 清华大学深圳国际研究生院 一种自贴附仿生章鱼吸盘微纳结构干电极
CN112980203A (zh) * 2021-02-18 2021-06-18 重庆大学 一种柔性超声衰减膜及其应用
CN113073463A (zh) * 2021-03-15 2021-07-06 浙江理工大学 一种可用于人体温度信号实时监测的蚕丝基柔性传感器的制备方法
CN114605674A (zh) * 2022-04-22 2022-06-10 福州大学 一种高比电容聚苯胺复合柔性导电水凝胶及其制备方法
CN114605674B (zh) * 2022-04-22 2023-06-16 福州大学 一种高比电容聚苯胺复合柔性导电水凝胶及其制备方法
CN117224126A (zh) * 2022-06-06 2023-12-15 中国科学院上海硅酸盐研究所 一种柔性生物电干电极及其制备方法和应用
CN116295968A (zh) * 2023-02-27 2023-06-23 昆明理工大学 一种柔性压力传感器及其制备与应用
CN116217975A (zh) * 2023-03-21 2023-06-06 福建工程学院 一种有机无机杂化双导电网络聚乙烯醇复合水凝胶的制备方法

Similar Documents

Publication Publication Date Title
WO2018090329A1 (zh) 一种具有功能化的柔性电极及其制备方法
CN106601338B (zh) 一种具有功能化的柔性电极及其制备方法
Yang et al. Functional hydrogel interface materials for advanced bioelectronic devices
Chang et al. Advances in the formulations of microneedles for manifold biomedical applications
Sunwoo et al. Wearable and implantable soft bioelectronics: device designs and material strategies
McGlynn et al. The future of neuroscience: flexible and wireless implantable neural electronics
Feiner et al. Tissue–electronics interfaces: from implantable devices to engineered tissues
Rybak et al. Evolution of nanostructured skin patches towards multifunctional wearable platforms for biomedical applications
Liu et al. Biomedical applications of polymeric microneedles for transdermal therapeutic delivery and diagnosis: current status and future perspectives
JP6399968B2 (ja) 生体吸収性基板上の埋め込み型バイオメディカルデバイス
Park et al. Conformal fixation strategies and bioadhesives for soft bioelectronics
Khan et al. Implantable hydrogels as pioneering materials for next-generation brain–computer interfaces
CN109350846B (zh) 一种功能化宽幅植入式微电极阵列及其制备方法与应用
Rinoldi et al. In vivo chronic brain cortex signal recording based on a soft conductive hydrogel biointerface
TW201138743A (en) Implantable biomedical devices on bioresorbable substrates
CN106344212A (zh) 一种基于液态金属传感的人造皮肤
WO2012139124A1 (en) Regenerative microchannel electrode array for peripheral nerve interfacing
Li et al. Bioinspired flexible electronics for seamless neural interfacing and chronic recording
Song et al. Recent advances in 1D nanomaterial‐based bioelectronics for healthcare applications
Zhu et al. Tissue/Organ Adaptable Bioelectronic Silk‐Based Implants
Castagnola et al. Flexible and soft materials and devices for neural interface
Mohapatra et al. Electric stimulus-responsive chitosan/MNP composite microbeads for a drug delivery system
Zhang et al. Recent progress of hydrogels in brain-machine interface
Ma et al. Multifunctional Hydrogel Materials for Advanced Neural Interfaces
Lu et al. Hierarchical Micro/Nano-Structured Biomaterials for Wound Healing

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16921750

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16921750

Country of ref document: EP

Kind code of ref document: A1

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 01/10/2019)

122 Ep: pct application non-entry in european phase

Ref document number: 16921750

Country of ref document: EP

Kind code of ref document: A1