WO2018073995A1 - Armoire de biosécurité et dispositif à air propre - Google Patents

Armoire de biosécurité et dispositif à air propre Download PDF

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Publication number
WO2018073995A1
WO2018073995A1 PCT/JP2017/016183 JP2017016183W WO2018073995A1 WO 2018073995 A1 WO2018073995 A1 WO 2018073995A1 JP 2017016183 W JP2017016183 W JP 2017016183W WO 2018073995 A1 WO2018073995 A1 WO 2018073995A1
Authority
WO
WIPO (PCT)
Prior art keywords
safety cabinet
work space
clean
pass box
air
Prior art date
Application number
PCT/JP2017/016183
Other languages
English (en)
Japanese (ja)
Inventor
金子　健
博利 佐藤
Original Assignee
株式会社日立産機システム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社日立産機システム filed Critical 株式会社日立産機システム
Priority to US16/325,242 priority Critical patent/US10874012B2/en
Priority to JP2018546141A priority patent/JP6650048B2/ja
Publication of WO2018073995A1 publication Critical patent/WO2018073995A1/fr

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Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05F—STATIC ELECTRICITY; NATURALLY-OCCURRING ELECTRICITY
    • H05F3/00—Carrying-off electrostatic charges
    • H05F3/06—Carrying-off electrostatic charges by means of ionising radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
    • A61G10/00—Treatment rooms or enclosures for medical purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L1/00—Enclosures; Chambers
    • B01L1/04—Dust-free rooms or enclosures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L1/00—Enclosures; Chambers
    • B01L1/50—Enclosures; Chambers for storing hazardous materials in the laboratory, e.g. cupboards, waste containers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F7/00—Ventilation
    • F24F7/04—Ventilation with ducting systems, e.g. by double walls; with natural circulation
    • F24F7/06—Ventilation with ducting systems, e.g. by double walls; with natural circulation with forced air circulation, e.g. by fan positioning of a ventilator in or against a conduit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2279/00—Filters adapted for separating dispersed particles from gases or vapours specially modified for specific uses
    • B01D2279/50—Filters adapted for separating dispersed particles from gases or vapours specially modified for specific uses for air conditioning
    • B01D2279/51—Filters adapted for separating dispersed particles from gases or vapours specially modified for specific uses for air conditioning in clean rooms, e.g. production facilities for electronic devices, laboratories
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/42—Auxiliary equipment or operation thereof
    • B01D46/4209—Prevention of static charge, e.g. by grounding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/082—Handling hazardous material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/085—Protection against injuring the user

Definitions

  • the present invention relates to a safety cabinet and a clean air device in industrial fields such as regenerative medicine, medical care, and pharmaceuticals.
  • clean air devices such as a clean bench and a clean booth have been used to secure a safety cabinet and a local clean space.
  • the clean air device has an isolation performance capable of protecting a sample from external germs by providing an air barrier and working in a partitioned space having an opening in a part thereof.
  • Patent Document 1 is a simplified connection structure, and can be transferred to another safety cabinet without taking out the material under experiment that may cause infection from the work space to another safety cabinet. It is an object of the present invention to provide a cabinet, and to provide a safety cabinet that simplifies the structure of the connecting portion of the connection type safety cabinet and prevents bacteria and viruses by controlling pressure. For this reason, in a plurality of connected safety cabinets, the circulation channels of the connected safety cabinets are connected to be the same space, and the work spaces of the plurality of safety cabinets are connected in the shared circulation channel. In this way, a connecting portion connecting space is disclosed (see summary).
  • Patent Document 1 connects the working spaces of two safety cabinets, forms a connecting part connecting space at the connecting part, and forms the connecting part connecting space in a common negative pressure contaminated plenum. This reduces the possibility that bacteria / viruses will leak out of the safety cabinet from the connecting space.
  • Patent Document 1 does not take into account the charge removal in the safety cabinet or in the connecting portion of the connected safety cabinet.
  • a safety cabinet is used to eliminate the risk of contamination. It is conceivable to deliver a cell culture container by connecting a clean booth.
  • the clean booth is equipped with people to handle various equipment, and in the safety cabinet, manual work using insulators such as petri dishes, bottles, pipettes, plastics, etc. is involved. May be tinged. For this reason, charged objects may be drawn to the hand during the work, or the waste contained in the filth can placed in the safety cabinet may be lifted due to charging. Also, if charged dust is placed in the safety cabinet while attached to the equipment, it may cause sample contamination.
  • an object of the present invention is to reduce the risk of contamination due to electrification and to ensure workability in a safety cabinet or a clean air device in which a safety cabinet and a clean booth are connected.
  • a safety cabinet which is formed from a work space formed on the inner surface side of the front shutter, a lower surface side, a side surface, and a rear surface side of the work space, and an outer portion of the safety cabinet, and flows into the work space.
  • a circulating flow path for exhausting the air, and an air supply unit that is disposed on the upper surface of the work space and supplies air to the work space, and the air supplied to the work space is disposed on the front surface of the safety cabinet. It is a safety cabinet characterized in that an ionizer is provided immediately above an airflow branch point that branches to the back.
  • the present invention in a clean air device in which a safety cabinet or a safety cabinet and a clean booth are connected, the risk of contamination due to electrification and workability can be ensured.
  • FIG. 6 is a cross-sectional plan view of a work space of a safety cabinet in Example 2.
  • FIG. 6 is a cross-sectional perspective view of a safety cabinet in Example 3. It is the longitudinal cross-sectional view seen from the front of the periphery of the pass box which is a connection part of the safety cabinet and clean booth in Example 4.
  • This example describes an example in which only one ionizer is installed in a safety cabinet and the effect of neutralization is efficiently exhibited to reduce the risk of contamination due to charging and to ensure workability.
  • FIG. 1A and 1B are general configuration diagrams of a clean air device including a safety cabinet and a clean booth in the present embodiment.
  • 1A is a plan view
  • FIG. 1B is a front view
  • 10 is a safety cabinet
  • 20 is a clean booth
  • 30 is a fan filter unit (FFU (Fan Filter Unit)).
  • the safety cabinet 10 is a device in which a person performs cell operations such as cell culture by putting only an arm.
  • the clean booth 20 is a culture / centrifugal equipment booth or a receiving material booth, and is a space where people enter and work.
  • the FFU 30 is a unit in which a fan and a filter are incorporated in a housing, and air sucked by the fan is purified through a HEPA filter and sent out as clean air.
  • the safety cabinet 10 and the clean booth 20 are connected by a pass box 40 (see FIG. 4B).
  • the pass box 40 is provided with a connection opening in a part of the side wall of the work space 12, and delivers materials or samples that may be infected from the work space 12 of the safety cabinet 10 to the clean booth 20 without taking out from the safety cabinet. It has a possible structure.
  • the pass box 40 has a pass box door 41, and the flow path to the clean booth 20 can be shut off by closing the pass box door 41.
  • FIG. 2 is an image diagram of the right side cross-sectional view of the safety cabinet in the present embodiment.
  • the safety cabinet 10 includes a front shutter 11, a work space 12 that is formed on the inner surface side of the front shutter 11 and maintains a negative pressure state, a lower surface side, a side surface, a rear surface side of the work space 12, and the safety cabinet 10.
  • a circulation passage 13 is formed from the outer portion of the main body and exhausts air flowing into the work space 12.
  • the operator inserts his arm from the front opening of the safety cabinet 10, looks into the work space 12 from the front shutter 11, and performs a cell manipulation work in the work space 12.
  • the front opening is a space between the lower end of the front shutter 11 and the front grill 17.
  • the air sucked from the front opening passes through the circulation passages 13 on the lower part, the rear face, and the side face of the work space 12 and is sucked into a blower (not shown).
  • a part of the air sucked into the blower is filtered by a circulation HEPA filter bottle (not shown), and is filtered as clean air into the work space 12 and the other part is filtered by an exhaust HEPA filter bottle (not shown) and is used as clean air as a safety cabinet.
  • 10 is discharged as a safety cabinet exhaust airflow 15.
  • a safety cabinet blowing air flow 16 is supplied into the working space 12 from a blowing punching plate 21 disposed on the upper surface of the working space 12.
  • the safety cabinet blowout air flow 16 cleans the inside of the work space 12, a part is sucked from the front grille 17, and another part is sucked from the safety cabinet back slit 14 described later, passes through the circulation channel 13, and is sucked into the blower. .
  • the present embodiment is characterized in that an ionizer 60 is installed immediately above the airflow branching point 18 where the safety cabinet blown airflow 16 in the work space 12 divides back and forth in the vicinity of the work table 19.
  • the ions generated from the electrode needles of the ionizer ride on the safety cabinet blown air flow 16 and spread into the work space 12, and are divided back and forth at the air flow branching point 18 and flow to the equipment and sample on the work table 19.
  • the neutralization of the entire table 19 can be performed efficiently.
  • the airflow branch point 18 is a point where the safety cabinet blown airflow 16 is divided into the front and back in the vicinity of the work table 19, airflow stagnation occurs.
  • the airflow branch point by installing the ionizer 60 directly above the airflow branch point, the airflow is drawn from the surroundings directly below the ionizer 60 and the wind speed is higher than the surroundings immediately below the ionizer 60. Thereby, the stagnation of the airflow is eliminated, and there is an effect that dust accompanying the work in the work space 12 can be efficiently exhausted.
  • This example describes an example of efficiently removing static electricity at the inlet of a filth can when the filth can is installed on a workbench of a safety cabinet.
  • FIG. 3A is a right side view of the safety cabinet 10 in the present embodiment, and is a view in which a filth can 50 is installed in the work space 12, and FIG. 3B is a plan view of the work table 19 of the safety cabinet 10 shown in FIG. 3A. is there.
  • the ionizer 60 is disposed at the same position as in the first embodiment.
  • the present embodiment is characterized in that the inlet of the filth can 50 is arranged on a straight line connecting the electrode needle of the ionizer 60 and the safety cabinet back slit 14.
  • a rear slit is generally provided at the lower end of the rear surface of the safety cabinet, but a new rear slit is provided at a height near the inlet of the filth can 50 in addition to the rear slit.
  • the filth can 50 is for temporarily putting the waste generated in the work space 12 and is a bag made of SUS can or polyethylene. In many cases, the lid is left open and the lid is not closed. Dispose of polyethylene bags and pipes used for cleaning, etc. that contain pipettes used in the work, but waste cans due to frictional charges accompanying the work and peeling charges that occur when opening bags containing equipment In some cases, the waste in the container floats out of the filth can, or when the waste is disposed in the trash can, the waste may be drawn to the hand.
  • the charge removal effect of the ionizer can be exhibited also at the inlet of the filth can 50, and the cause of contamination such as the above phenomenon can be prevented.
  • This example describes an example in which a static air device in which a safety cabinet and a clean booth are connected to increase the neutralization effect in the pass box.
  • FIG. 4A shows a right side view of the safety cabinet 10 in this embodiment
  • FIG. 4B shows a cross-sectional perspective view.
  • this embodiment is characterized in that a pass box connecting portion inner surface slit 45 is provided in the pass box.
  • the safety cabinet blown air flow 16 spreads to the left and right pass boxes 40 in the work space 12, and discharge of the pass box 40, in particular, discharge of the entire bottom of the pass box becomes possible.
  • the charged and adhering dust can be removed by discharging with the pass box and exhausted from the inner slit 45 of the pass box connecting portion. Therefore, it is possible to suppress dust from being brought into the work space 12 of the safety cabinet 10 and maintain cleanliness.
  • This example describes an example of further enhancing the charge removal effect in the pass box in a clean air device in which a safety cabinet and a clean booth are connected.
  • FIG. 5 is a longitudinal sectional view as seen from the front of the periphery of the pass box 40, which is a connecting part of the safety cabinet and the clean booth in this embodiment.
  • a partition curtain 44 is provided on the upper surface near the center of the pass box, and a pass box connecting portion inner surface slit 45 is provided on the side of the pass box door 41 from the curtain 44 and above the lowermost part of the curtain 44.
  • the curtain 44 is preferably made of transparent glass or translucent silicon.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Combustion & Propulsion (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Ventilation (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

Le but de la présente invention est de produire un dispositif à air propre qui peut réduire le risque de contamination due à l'électricité statique. L'invention concerne une armoire de biosécurité ou un dispositif à air pur qui relie une armoire de biosécurité et une cabine propre, un éliminateur d'électricité statique (ioniseur) qui produit une décharge à effet couronne au moyen de la concentration d'un champ électrique sur une électrode de décharge en forme d'aiguille et élimine l'électricité statique avec de l'air ionisé étant disposé directement au-dessus d'un point de bifurcation d'écoulement d'air où l'air apporté à un espace de travail bifurque vers la face avant et vers la face arrière à l'intérieur de l'armoire de biosécurité.
PCT/JP2017/016183 2016-10-19 2017-04-24 Armoire de biosécurité et dispositif à air propre WO2018073995A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US16/325,242 US10874012B2 (en) 2016-10-19 2017-04-24 Biosafety cabinet and clean air device
JP2018546141A JP6650048B2 (ja) 2016-10-19 2017-04-24 安全キャビネット及びクリーンエア装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016204795 2016-10-19
JP2016-204795 2016-10-19

Publications (1)

Publication Number Publication Date
WO2018073995A1 true WO2018073995A1 (fr) 2018-04-26

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PCT/JP2017/016183 WO2018073995A1 (fr) 2016-10-19 2017-04-24 Armoire de biosécurité et dispositif à air propre

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US (1) US10874012B2 (fr)
JP (1) JP6650048B2 (fr)
WO (1) WO2018073995A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019187201A1 (fr) * 2018-03-26 2019-10-03 シャープ株式会社 Dispositif de maintien et d'entretien d'espace propre, structure de construction, procédé de culture de cellules et procédé de production de cellules
JP2020150876A (ja) * 2019-03-20 2020-09-24 三機工業株式会社 安全キャビネット

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111334429A (zh) * 2020-03-25 2020-06-26 北京双诚联盈净化工程技术有限公司 一种模块式多功能细胞工作站

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6196342A (ja) * 1984-10-17 1986-05-15 Ebara Corp 空気清浄方法
JP2006043521A (ja) * 2004-08-02 2006-02-16 Hitachi Industrial Equipment Systems Co Ltd 安全キャビネット
JP2011147842A (ja) * 2010-01-19 2011-08-04 Vessel Industrial Co Ltd 除電除塵装置
JP2014073457A (ja) * 2012-10-04 2014-04-24 Hitachi Industrial Equipment Systems Co Ltd 安全キャビネット

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008149290A (ja) * 2006-12-20 2008-07-03 Hitachi Industrial Equipment Systems Co Ltd 安全キャビネット
JP6535104B2 (ja) * 2015-11-18 2019-07-03 Ｐｈｃホールディングス株式会社 バイオハザード対策用キャビネットおよびクリーンベンチ
CN205435809U (zh) 2015-12-31 2016-08-10 元森肽德生物医药科技（天津）有限公司 一种生物医药实验中超净工作台

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6196342A (ja) * 1984-10-17 1986-05-15 Ebara Corp 空気清浄方法
JP2006043521A (ja) * 2004-08-02 2006-02-16 Hitachi Industrial Equipment Systems Co Ltd 安全キャビネット
JP2011147842A (ja) * 2010-01-19 2011-08-04 Vessel Industrial Co Ltd 除電除塵装置
JP2014073457A (ja) * 2012-10-04 2014-04-24 Hitachi Industrial Equipment Systems Co Ltd 安全キャビネット

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019187201A1 (fr) * 2018-03-26 2019-10-03 シャープ株式会社 Dispositif de maintien et d'entretien d'espace propre, structure de construction, procédé de culture de cellules et procédé de production de cellules
JP2020150876A (ja) * 2019-03-20 2020-09-24 三機工業株式会社 安全キャビネット
JP7280077B2 (ja) 2019-03-20 2023-05-23 三機工業株式会社 安全キャビネット

Also Published As

Publication number Publication date
US20190208613A1 (en) 2019-07-04
JPWO2018073995A1 (ja) 2019-04-04
JP6650048B2 (ja) 2020-02-19
US10874012B2 (en) 2020-12-22

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