WO2018062971A1 - 미세 유체 채널에 기반하여 순간 유화된 멀티플 제형을 함유하는 화장품 조성물 제조 장치 - Google Patents

미세 유체 채널에 기반하여 순간 유화된 멀티플 제형을 함유하는 화장품 조성물 제조 장치 Download PDF

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Publication number
WO2018062971A1
WO2018062971A1 PCT/KR2017/011066 KR2017011066W WO2018062971A1 WO 2018062971 A1 WO2018062971 A1 WO 2018062971A1 KR 2017011066 W KR2017011066 W KR 2017011066W WO 2018062971 A1 WO2018062971 A1 WO 2018062971A1
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WIPO (PCT)
Prior art keywords
fluid
channel
trauma
outermost
multiple formulation
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PCT/KR2017/011066
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English (en)
French (fr)
Korean (ko)
Inventor
한경섭
남진
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(주)아모레퍼시픽
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Publication of WO2018062971A1 publication Critical patent/WO2018062971A1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging

Definitions

  • the present invention relates to a cosmetic composition manufacturing apparatus for discharging the multiple formulation produced by the instant emulsification is made by moving the trauma fluid and the inner fluid fluid along the microfluidic channel, specifically the fluid moving along the microfluidic channel Multiple formulations for producing emulsion particles in which the outermost fluid envelops the outer surface of the emulsified particles by allowing the emulsified material produced in the instant emulsified manner to meet the outermost fluid in the instant emulsified manner using their special fluid behavior characteristics. It relates to a cosmetic composition production apparatus containing a.
  • the fluid emulsification technique refers to a technique for dispersing a liquid of one of two fluids that do not mix with each other, such as water and oil, into small particles and dispersing the liquid in a stable state in the other liquid.
  • emulsification techniques are widely applied to lotions, creams, essences, massage creams, cleansing creams, makeup bases, foundations, eyeliners, mascaras and the like.
  • O / W (Oil in Water) emulsion particles are prepared by uniformly dispersing a hydrophobic fluid such as oil into a small particle state in a hydrophilic fluid such as water, or in a hydrophilic fluid By uniformly dispersing in a small particle state to prepare a water in oil (W / O) emulsion particles.
  • a hydrophobic fluid such as oil
  • W / O water in oil
  • Such O / W emulsified particles and W / O emulsified particles are called emulsions or emulsified materials.
  • an emulsified material using a hydrophilic fluid and a hydrophobic fluid was prepared by using a physical method.
  • a stirrer is operated to disperse particles of another fluid to one fluid after pouring both hydrophilic and hydrophobic fluids into a large container.
  • a stirrer was used such as a homomixer or a microfluidizer. That is, O / W emulsified particles or W / O emulsified particles were prepared by pouring a hydrophilic fluid and a hydrophobic fluid into a huge container and then mixing the fluids with each other using a stirrer.
  • the above work can be called an oil painting work.
  • the interfacial energy between the hydrophilic fluid and the hydrophobic fluid is lowered to easily form emulsions such as O / W emulsified particles or W / O emulsified particles, and maintain the interfacial membrane more firmly.
  • emulsions such as O / W emulsified particles or W / O emulsified particles
  • the emulsion is united, and the hydrophilic fluid and the hydrophobic fluid are separated from each other again. Can be.
  • a surfactant is added to maintain the emulsion state for a long time.
  • the emulsified particles completed through the temporary emulsification operation are transferred to a container containing a hydrophilic fluid or a hydrophobic fluid to emulsify the emulsified particles having completed the temporary emulsification operation again.
  • the W / O emulsified particles produced through the emulsifying operation may be injected into a container containing a hydrophilic fluid, and the W / O / W emulsified particles may be manufactured through the second stirring operation. That is, the hydrophilic fluid covers the outer surface of the W / O emulsified particles, so that multiple formulations of the W / O / W emulsified particles can be produced.
  • the O / W emulsified particles produced through the emulsifying operation may be injected into a container containing a hydrophobic fluid, and the O / W / O emulsified particles may be manufactured through the second stirring operation. That is, O / W / O emulsified particles, which are multiple formulations (multiple emulsions), can be prepared by covering the outer surface of the O / W emulsified particles with a hydrophobic fluid.
  • the multiple formulation is a material in which an emulsified material is dispersed in an emulsified material, in which the dispersed particles are dispersed in smaller particles than the emulsified particles produced through a temporary emulsifying operation.
  • This multiple formulation has the advantage of having both the moisturizing effect of the W / O emulsified particles and the fresh feeling of the O / W emulsified particles, and depending on the form of the formulation (W / O / W or O / W / O) From the feeling of use of the formulation to the feeling of the innermost emulsified particles can be felt sequentially.
  • the prepared emulsion particles are poured into a container containing a hydrophilic fluid or a hydrophobic fluid to complete the multiple formulation, the manufacturing process is very
  • the complex and prepared formulations also have a problem in that the emulsified particles are unstable, and it is difficult to obtain a stabilized formulation in the long term because it does not include a step of increasing the number of primary emulsifiers.
  • An object of the present invention is to provide a user with multiple formulations (multi-emulsions) such as W / O / W emulsified particles or O / W / O emulsified particles which are fabricated in an instantaneous emulsified manner using the properties of the fluids in the microfluidic channel.
  • the present invention provides a cosmetic composition manufacturing apparatus containing multiple formulations, which can be used at the same time as the production of the multiple formulations, thereby making use of the user's product.
  • the housing is installed the pump operable by the user;
  • a fluid receiving portion provided in the housing and including a trauma container for receiving a trauma fluid forming an outer trauma of an emulsifying material and an inner trauma container for receiving an inner trauma fluid forming an inner trauma of the emulsifying material;
  • An outermost vessel provided in the housing and containing an outermost fluid for contacting the emulsifying material to form a multiple formulation;
  • a second channel provided with a space in communication with the first channel to form a movement passage of the emulsifying material and allowing the outermost fluid delivered from the outermost container to merge with the emulsifying material to form the multiple formulation;
  • a tube for discharging the multiple formulation passed through the second channel may be provided with a cosmetic composition manufacturing apparatus containing the multiple formulation.
  • first channel and the second channel may be provided with a cosmetic composition manufacturing apparatus containing a multiple formulation, characterized in that having a structure corresponding to each other.
  • the first channel may include a trauma fluid injection port through which the trauma fluid is injected; An internal fluid fluid inlet through which the internal fluid is injected; And a first emulsifying material passage, which is a path through which the emulsifying material formed when the trauma fluid and the inner wound fluid meet each other is moved from the first channel to the second channel.
  • An apparatus may be provided.
  • the second emulsified material passage may be provided with a cosmetic composition manufacturing apparatus containing multiple formulations, characterized in that the portion corresponding to the inlet fluid inlet of the first channel.
  • the first channel may include a first branch pipe and a first branch pipe disposed in a form surrounding the trauma fluid and an inlet fluid inlet through which the trauma fluid enters such that the trauma fluid and the injured fluid meet each other.
  • a bifurcation tube wherein the trauma fluid and the internal fluid are met at the lamination portions of the first branch pipe and the second branch pipe, and in the second channel, the outermost fluid surrounds the emulsifying material.
  • a plurality of branch tubes disposed to surround the second emulsion material passage through which the emulsion material is introduced such that the outermost fluid and the emulsion material meet each other, wherein the outermost fluid and the emulsion material comprise the plurality of branch tubes.
  • Apparatus for producing a cosmetic composition containing multiple formulations may be provided, wherein the multiple formulations meet at the lamination.
  • the first channel may further include an emulsifying action portion in communication with the lamination portion and emulsifying the trauma fluid and the inner phase fluid to form the emulsifying material
  • the second channel includes: the multiple formulation lamination portion;
  • An apparatus for producing a cosmetic composition containing multiple formulations may be provided, the apparatus further comprising an emulsification function communicating with the emulsifying material and the outermost fluid to form the multiple formulation.
  • the emulsifying action portion of the first channel is an orifice having a width smaller than the lamination portion
  • the emulsification action portion of the second channel is a cosmetic composition containing a multiple formulation is an orifice having a width smaller than the multiple formulation lamination portion.
  • At least a portion of the second channel may be provided with a cosmetic composition manufacturing apparatus containing a multiple formulation is formed to have a hydrophilicity corresponding to the hydrophilicity of the outermost fluid.
  • first channel and the second channel may be provided with a cosmetic composition manufacturing apparatus containing a multiple formulation is arranged in a structure stacked on each other.
  • the present invention proposed, since the multiple formulations (multiple emulsions) are produced by the user's pump operation and the external discharge of the multiple formulations is made, it is possible to manufacture and supply the multiple formulations at the time required by the user. There is an advantage.
  • the present invention utilizes the special fluid behavior properties of fluids moving along the microfluidic channel to conveniently prepare multiple formulations in an instant emulsified manner from being stored as raw materials in the water and oil phase at the time required by the user.
  • Figure 2 is a plan view showing the configuration of a first channel of the fluid channel of the device.
  • 3A and 3B are cross-sectional views of an emulsified material showing O / W emulsified particles or W / O emulsified particles formed through the first channel.
  • FIG. 4 is a plan view showing a configuration of a second channel stacked on top of the first channel among the fluid channels of the device.
  • 5A and 5B are cross-sectional views of an emulsified material showing a state in which W / O / W emulsified particles or O / W / O emulsified particles are formed through the second channel.
  • FIG. 6 is a view showing an experimental example of the W / O / W emulsion particles produced through the fluid channel.
  • FIG. 1 is a perspective view showing a cosmetic composition manufacturing apparatus containing multiple formulations according to an embodiment of the present invention.
  • Figure 2 is a plan view showing the configuration of the first channel of the fluid channel of the device
  • Figures 3a and 3b shows the appearance of O / W emulsified particles or W / O emulsified particles passing through the first channel It is a cross section of an emulsifier.
  • the cosmetic composition manufacturing apparatus 1 which concerns on this invention is formed in the housing 10 by the external shape.
  • One side of the housing 10 may be provided with a pump 70 operable by a user, the user can discharge the material in the housing 10 to the outside by pressing the pump 70.
  • the pump 70 operable by a user
  • the pressure of the movement path of the materials in the housing 10 becomes high.
  • the negative pressure is applied to the moving path of the materials and the materials are discharged to the outside.
  • the pump 70 is a means for providing energy for discharging the fluid from the containers 21, 22, and 45 and emulsifying it instantaneously and then discharging it through a discharge hole formed outside the housing 10.
  • the pump 70 is provided at one side of the housing 10. Arranged, the user can operate the operation portion is exposed to the outside of the housing 10, the connection portion for discharging the mixed liquid to the outside may be provided inside the housing 10.
  • the pressure generated by the pump 70 the raw materials contained in the trauma container 21, the inner wound container 22, and the outermost container 45 are provided to the fluid channel 100, and the fluid channel 100 is supplied to the fluid channel 100.
  • the supplied raw materials may be discharged to the pump 70 through the tube 60 after being instantaneously emulsified while moving along a predetermined path.
  • a series of flow paths can be formed from the pump 70 to the respective containers 21, 22, 45 in communication with each other.
  • the pump 70 is described as an example that includes a discharge portion exposed to the outside of the housing 10 to discharge the cosmetic, this is only one example and the spirit of the present invention is not limited thereto.
  • the discharge portion may be provided separately from the pump 70, which may be connected to any point in the series of flow paths connected from the containers 21, 22, 45 to the discharge portion to provide pressure. have.
  • the pump 70 is shown as an example of a push-type pump to apply a negative pressure on the movement path of the fluid in the housing 10 by the user presses and releases the operation unit.
  • the ejection of the raw materials from the containers 21, 22, and 45, the movement in the fluid channel 100, and the ejection of the cosmetic are all realized by the pressure in a single direction formed by the pump 70. Since it can be, there is an advantage that the configuration of the device can be simplified.
  • the housing 10 is provided with a trauma container 21 in which the trauma fluid is accommodated, and an inner trauma container 22 in which the trauma fluid is accommodated.
  • the trauma fluid may be any one of an oil phase and an aqueous phase
  • the inner phase fluid may be any of an oil phase, an aqueous phase, and a gas phase.
  • the trauma container 21 and the inner container 22 may be provided inside the housing 10 to form one fluid container 20.
  • a blocking film 23 extending in the vertical direction and separating the inner space of the fluid receiving part 20 is installed at the center of the fluid receiving part 20. The trauma fluid is accommodated on one side of the barrier film 23 to form the trauma container 21, and the trauma fluid is received on the other side to form the inner container 22.
  • the outermost phase fluid when the inner phase fluid is an oil phase, the outermost phase fluid may be an oil phase, and when the inner phase fluid is an aqueous phase, the outermost phase fluid may also be an aqueous phase.
  • the spirit of the present invention is not limited thereto, and the inner phase fluid and the outermost fluid may be combined in various forms as necessary.
  • the outermost outer container 45 is connected to the outermost outer fluid injection pipe 46 which is a movement path of the outermost outer fluid stored therein. That is, the outermost fluid contained in the outermost container 45 may be discharged out of the outermost container 45 along the outermost fluid injection tube 46.
  • the outermost phase fluid may be any one of an oil phase and an aqueous phase.
  • the opening and closing control such as a valve so that the contents can be discharged to the flow path (30, 40, 46) only when pressure is applied to the connection portion of each container (21, 22, 45) and the flow path (30, 40, 46) Means may be provided.
  • the microfluidic channel 100 using a single negative pressure was applied instead of using a conventional syringe pump using a positive pressure as a cosmetic composition manufacturing apparatus. That is, the present invention has the advantage that the apparatus according to the present invention can be directly applied to the general cosmetic container and pump structure by using a method in which a single negative pressure is applied to the microfluidic channel 100 as a discharge method of the emulsified material.
  • the interfacial fluid and the interphase fluid have high interfacial tension and do not easily mix with each other, it has been quite difficult to form and maintain emulsion particles without using an excessive amount of surfactant (1% to 5%).
  • surfactants and the like are used. There is an advantage that the emulsification can be achieved quickly by not using or adding a minimum amount.
  • the principle that any one of the two fluids that do not easily mix with each other to break the flow of the other fluid to form the emulsion particles also helps to reduce the surfactant.
  • the emulsification method using the microfluidic channel 100 has many advantages as described above, but there is a limit in the production speed compared to the existing emulsification apparatus using a large tank and an agitator, so it is difficult to apply to the cosmetic manufacturing apparatus.
  • the present invention has developed a microfluidic channel 50 applicable to the container, and adopted an instant emulsification method that enables emulsification based on the amount of discharge once at a desired time.
  • the fluid channel 100 may be formed on the bottom surface of the housing 10, for example, in the form of a moving passage for moving the fluid.
  • the fluid channel 100 may include a first channel 50 constituting a lower portion and a second channel 80 stacked on an upper portion of the first channel 50.
  • the first channel 50 may be stacked on the second channel 80 or may be arranged in a non-laminated structure.
  • injection holes communicating with the trauma fluid injection tube 30 and the internal injury fluid injection tube 40 may be formed in the first channel 50. That is, the first channel 50 is an inflow passage of the trauma fluid inlet 51, which is an inflow passage of the trauma fluid moved along the trauma fluid injection tube 30, and an inflow passage of the inner fluid, which is moved along the inner trauma fluid injection tube 40.
  • An internal wound fluid inlet 54 is included.
  • the trauma fluid introduced into the first channel 50 through the trauma fluid inlet 51 may be divided into a first branch pipe 52 and a second branch pipe 53, and moved to a downstream side toward the pump 70.
  • downstream refers to a direction in which the fluid stored in the fluid receiving portion 20 is discharged to the outside through the pump 70 via the first channel 50 and the tube 60 by a user's pump operation. it means.
  • the inner phase fluid introduced into the first channel 50 through the inner wound fluid inlet 54 may be moved downstream along the inner wound fluid moving tube 55.
  • the trauma fluid moved along the first branch pipe 52 and the second branch pipe 53 and the inner wound fluid moved along the inner wound fluid moving tube 55 meet each other at the lamination part 56. That is, the lamination portion 56 means a point where the trauma fluid and the inner fluid meet first in the housing 10.
  • the trauma fluid and the internal fluid which are met at the lamination part 56 pass through the emulsification part 58 and become an emulsion, that is, an emulsion material.
  • an emulsion material that is, an emulsion material.
  • the orifice 58 having a relatively narrower width than the lamination portion 56 is provided as the emulsifying action portion (58).
  • the trauma fluid and the inner fluid which are met at the lamination part 56 pass through the orifice 58 and the direction of force of the trauma fluid in the narrowing direction (vertical direction) inside the orifice 58 and the flow direction of the fluid (horizontal direction) (orifice ( 58) the shear force is applied to the inner phase fluid in a diagonal direction gathered toward the center side to interrupt the flow of the inner phase fluid and form an emulsifying material.
  • capillary instability increases when two non-mixing fluids pass through the orifice 58 with the interface unstable, and the channel with the orifice 58 does not have a small energy compared to the channel without the channel.
  • the flow can be interrupted and the broken internal fluid is formed into a sphere to maintain a stable state.
  • the emulsification unit 58 is to allow the trauma fluid to stop the flow of the mixed fluid so that the mixed fluid is dispersed in the trauma fluid in the form of particles.
  • the orifice is provided as the emulsification unit 58.
  • the spirit of the present invention is not limited thereto.
  • the emulsification method using the orifice as in the present embodiment may be referred to as flow-focusing emulsification, which allows the fluids of different phases to flow in the same direction, but by placing the orifices at the confluence of the trauma fluid This allows the flow to break (Flow-Focusing).
  • various embodiments may be applied to the emulsifying unit 58.
  • a method of emulsifying while moving fluids of different phases in the same direction (Co-Flow method), so that fluids of different phases may intersect.
  • Method of emulsifying while moving (Cross-Flow method)
  • Method of forming emulsified particles in the lamination part (Step Emulsification method)
  • Step Emulsification method by controlling the aspect ratio of the inlet of the trauma fluid to the lamination part and the inlet of the inner phase fluid to be large or low.
  • a method of forming emulsion particles by passing a mixed fluid of two phases through a hole of a membrane may be used (Membrane Emulsification method).
  • the emulsifying unit 58 may use a power source, for example, an electric field, a magnetic control, a centrifugal control, an optical control, a vibration control, a piezoelectric material.
  • a power source for example, an electric field, a magnetic control, a centrifugal control, an optical control, a vibration control, a piezoelectric material.
  • a channel in which emulsion particles are formed using Piezoelectric control or the like may be used.
  • the emulsifying unit 58 may form emulsified particles by changing the viscosity, interfacial tension and wettability of the fluid, for example, electrorheological (ER) or magnetorheological (MR) fluids, photo-sensitive Fluids may be applied.
  • ER electrorheological
  • MR magnetorheological
  • the emulsified material formed through the orifice 58 moves along the emulsified material moving tube 57.
  • upstream refers to the direction opposite to the "downstream”, which is opposite to the direction of movement of the fluid by the user's pump operation, that is, the pump 70, the tube 60, the fluid channel 100 and the fluid. Means the direction toward the receiving portion 20.
  • the size and content of the emulsified particles is an important factor in determining the quality of the cosmetics.
  • the injection ratio of the trauma fluid to the internal fluid is generally equal or higher.
  • the injection amount of the trauma fluid may be 1 to 30 times the injection amount of the internal fluid.
  • the inflow velocity of the fluid is determined by the structural elements of the fluid channel 100 and the flow conditions of the fluid, and thus the size and content of the emulsified particles. Will be different.
  • Structural elements of the fluid channel 100 may be, for example, the height ratio of the channel, the width of the orifice, and the width ratio of the injection channel of each fluid.
  • the flow conditions of the fluid may include, for example, the strength of the negative pressure, the flow rate ratio of the two fluids, and the viscosity ratio of the two fluids.
  • Emulsion particles have a smaller channel height, a narrow orifice width, a higher negative pressure intensity, a larger flow rate ratio of the trauma fluid to the internal fluid, and a higher viscosity of the internal fluid than the trauma fluid.
  • the size of the emulsion particles is increased, and on the contrary, the size of the emulsified particles is increased.
  • a method for adjusting the flow rate ratio between the inner-phase fluid and the trauma fluid a method of adjusting the inner diameter of each injection port of the inner-phase fluid and the trauma fluid is used. Specifically, when the inner diameter of the trauma fluid inlet is made twice as large as the inner diameter of the inner wound fluid inlet, the flow rate of the trauma fluid under the single negative pressure is increased by two times compared to the inner wound fluid. In this way, the flow rate ratio between the inner fluid and the outer fluid can be adjusted.
  • the configuration of the second channel 80 communicating with the first channel 50 is as follows.
  • FIG. 4 is a plan view showing a configuration of a second channel stacked on top of the first channel among the fluid channels of the device.
  • 5A and 5B are cross-sectional views of an emulsified material showing a state in which W / O / W emulsified particles or O / W / O emulsified particles are formed through the second channel.
  • the first channel 50 and the second channel 80 may have the same structure. That is, only the direction in which the first channel 50 and the second channel 80 are disposed may be different, and the overall structure may be the same.
  • the second channel 80 may be stacked on the first channel 50 while being rotated 180 degrees with respect to the first channel 50.
  • the second emulsifier passage 84 of the second channel 80 which communicates with the first emulsifier passage 59 of the first channel 50, is connected to the inner phase fluid inlet 54 of the first channel 50. It may be a corresponding part. That is, the emulsifying material introduced into the second channel 80 through the second emulsifying material passage 84 forms the inner phase of the multiple formulation.
  • the emulsified material introduced into the second channel 80 through the second emulsified material passage 84 is moved to the multiple formulation lamination 86 along the emulsified material piping 85.
  • the second channel 80 is formed with a path of movement of the outermost fluid delivered from the outermost fluid injection tube 46. Specifically, the outermost fluid stored in the outermost vessel 45 in the housing 10 is moved by the negative pressure along the outermost fluid inlet tube 46 to the outermost fluid inlet 81 of the second channel 80. do.
  • the outermost fluid inlet 81 of the second channel 80 is a portion corresponding to the trauma fluid inlet 51 of the first channel 50.
  • the outermost fluid introduced into the second channel 80 through the outermost fluid inlet 81 is moved to the multiple formulation lamination 86 through the branch pipes 82 and 83.
  • the multiple formulation lamination portion 86 corresponds to the lamination portion 56 of the first channel 50 and is a portion where the emulsion material and the outermost fluid meet.
  • the emulsion and the outermost fluid encountered in the multiple formulation lamination 86 are emulsified through the emulsification function 87a.
  • the orifice 87a having a relatively narrower width than the multiple formulation lamination 86 is provided as the emulsifying action 87a.
  • the outermost fluid and the emulsifying material, which are encountered at the multiple formulation laminations 86, pass through an orifice 87a having a relatively narrow width and meet each other so that the outermost fluid is narrowed (vertical direction) inside the orifice 87a.
  • Multiple formulations formed through the orifices 87a are moved along the multiple formulation delivery tubes 87. Multiple formulations passing through the multiple formulation delivery tube 87 are transferred to multiple formulation outlets 88 formed at the ends of the multiple formulation delivery tubes 87.
  • the multiple formulation outlet 88 communicates with the tube 60 to serve as a passageway for the multiple formulation to exit from the second channel 80.
  • the tube 60 may be made of a transparent material so that the user can check the emulsified material moved through the tube 60 from the outside.
  • the part surrounding the tube 60 of the housing 10 should also be made of a material that can be visually confirmed from the outside so that the emulsified material moved through the tube 60 can be confirmed from the outside.
  • the second channel 80 has been described as having substantially the same structure as the first channel 50, but the spirit of the present invention is not limited thereto.
  • the second channel 80 may be a microfluidic channel using various methods such that one fluid is dispersed in a particle state in another oilseed when two fluids having different phases meet.
  • the first channel 50 uses an orifice as an emulsifying action portion
  • the second channel 80 uses an emulsification action portion for supplying the first emulsion material at a predetermined angle to the outermost fluid flowing in one direction. It may be used.
  • the inner phase fluid is one of the oil phase (O), the water phase (W), and the gas phase (G), and the trauma fluid is one of the oil phase (O) and the water phase (G).
  • the outermost fluid is an oil phase (O)
  • Formulations can be prepared.
  • the outermost phase fluid is the water phase (W)
  • the inner phase fluid is one of the oil phase (O)
  • the outer phase fluid is one of the oil phase (O) and the water phase (G).
  • Formulations can be prepared.
  • both the inner fluid and the outer fluid, or both the outer fluid and the outer fluid are oil phases (O) or all water phases (W)
  • fluids having similar hydrophilic properties but not mixed with each other may be used. have.
  • the inner wall of the multiple dosage form moving tube 87 of the second channel 80 may be provided to have a property corresponding to the hydrophilicity of the outermost fluid.
  • the outermost fluid forming the trauma of the multiple dosage form is attracted to the inner wall side of the multiple dosage form moving tube 87, and the first emulsion is relatively far from the inner wall side of the multiple dosage form moving tube 87. The state in which the fluid makes up the appearance of the multiple formulations can remain stable and can be moved.
  • the inner wall of the multiple formulation delivery tube 87 may be coated with a hydrophobic material or a hydrophobic film, and when the outermost fluid is water, it may be coated with a hydrophilic material or a hydrophilic film.
  • the multiple formulation moving tube 87 but also other components of the second channel 80 may be formed to have properties corresponding to the hydrophilicity of the outermost fluid. That is, at least a portion of the second channel 80 may be formed to have a hydrophilicity corresponding to the hydrophilicity of the outermost fluid.
  • the inner wall of the emulsion moving tube 57 of the first channel 50 may be provided to have a property corresponding to the hydrophilicity of the trauma fluid.
  • the trauma fluid constituting the trauma of the emulsifier is attracted to the inner wall side of the emulsifier moving tube 57, and the inner phase fluid is relatively far from the inner wall side of the emulsifier moving tube 57, so that the emulsified state is stable. Can be retained and moved.
  • the trauma fluid is an oil
  • the inner wall of the emulsion transfer tube 57 may be coated with a hydrophobic material or a hydrophobic film, and when the trauma fluid is water, it may be coated with a hydrophilic material or a hydrophilic film.
  • not only the emulsifier moving tube 57 but also other components of the first channel 50 may be formed to have properties corresponding to the hydrophilicity of the trauma fluid. That is, at least a portion of the first channel 50 may be formed to have a hydrophilicity corresponding to the hydrophilicity of the trauma fluid.
  • a material having a contact angle with water of 0 degrees to 50 degrees may be used as the hydrophilic material or a hydrophilic film
  • a material having a contact angle with water of 70 degrees to 120 degrees may be used as the hydrophobic material or the hydrophobic film.
  • the process of taking out the O / W / O emulsified particles are as follows.
  • the trauma fluid may be a hydrophilic fluid such as water and the internal fluid may be a hydrophobic fluid such as oil. Hydrophilic fluid is then stored in the trauma container 21 and hydrophobic fluid is stored in the inner container 22.
  • the hydrophilic fluid moves to the trauma fluid inlet 51 of the first channel 50 along the trauma fluid inlet tube 30, and the hydrophobic fluid moves along the inner channel fluid inlet tube 40 to the first channel 50. It moves to the inner phase fluid inlet (54).
  • the hydrophilic fluid and the hydrophobic fluid moved to the first channel 50 meet each other at the lamination portion 56 of the first channel 50 and pass through the orifice 58.
  • the hydrophobic fluid is dispersed into small particles in the hydrophilic fluid. That is, the emulsified material in a form in which the hydrophilic fluid surrounds the hydrophobic fluid is made.
  • This process produces oil in water (O / W) emulsion particles in which water is dispersed in oil (see FIG. 3A).
  • the first channel 50 in particular, the emulsifier moving tube 57 may be made of a hydrophilic material or the inner wall through which the fluid flows may be coated with a hydrophilic material.
  • the emulsifying material has a configuration in which the inner wall is made of a hydrophilic fluid and the hydrophobic fluid is dispersed therein, when the emulsifying material moving tube 57 is made of a hydrophilic material, the hydrophilic fluid part of the emulsifying material is formed into an emulsifying material moving tube ( 57) to the inner wall. Therefore, the O / W emulsion particles as described above can be smoothly moved along the emulsion material moving tube 57 while maintaining the shape and structure.
  • the O / W emulsion particles passing through the first emulsifier material passage 59 of the first channel 50 are moved to the second channel 80 stacked on the first channel 50.
  • the O / W emulsified particles are formed along the second emulsifier passage 81 of the second channel 80 in communication with the first emulsifier passage 59 of the first channel 50. Is moved to.
  • the second emulsifier passageway 84 is a portion corresponding to the internal phase fluid inlet 54 of the first channel 50, and the O / W emulsified particles moved through the second emulsifier passageway 84 may cause an internal wound of the multiple formulation. Is achieved. That is, the O / W emulsified particles introduced into the second channel 80 through the second emulsifier passage 81 are moved to the multiple formulation lamination 86 along the emulsifier piping 86.
  • the outermost fluid is moved from the outermost container 45 to the outermost fluid inlet 81 formed in the second channel 80 through the outermost fluid inlet pipe 46.
  • the outermost fluid forms the trauma of the multiple formulation.
  • the outermost fluid may be a hydrophobic fluid having a similar range or substantially the same hydrophilicity as the inner wound fluid. That is, the outermost fluid may be a hydrophobic fluid so that the prepared multiple formulation may have a hydrophobic fluid on the outer surface of the O / W emulsion particles so as to have both the effects of the W / O emulsion particles and the effects of the O / W emulsion particles. have.
  • the outermost fluid introduced into the second channel 80 is moved to the multiple formulation lamination 86 along the outermost fluid transfer branch tubes 82 and 83 of the second channel 80.
  • the emulsion and the outermost fluid having passed through the multiple formulation laminations 86 are in contact with each other by the O / W emulsified particles and the outermost fluid in the orifice 87a to form O / W / O emulsified particles (FIG. 5A). Reference).
  • O / W / O emulsified particles produced according to this process is moved to the multiple formulation outlet 88 through the multiple formulation transfer tube (87).
  • the second channel 80 in particular, the multiple formulation moving tube 87 may be made of a hydrophobic material or the inner wall thereof may be coated with a hydrophobic material.
  • the multiple formulation is made of a hydrophobic fluid on the outside, when the multiple formulation transfer tube 87 is made of a hydrophobic material, the hydrophobic fluid portion of the emulsion material is attracted to the inner wall of the emulsion transfer tube 57. Therefore, the above O / W / O emulsified particles can be smoothly moved along the multiple formulation moving tube 87 while maintaining its shape and structure.
  • the O / W / O emulsified particles moved along the multiple formulation outlet 88 may be discharged to the user through the inlet of the pump 70 through the tube 60.
  • the trauma fluid may be a hydrophobic fluid such as an oil and the internal fluid may be a hydrophilic fluid such as water. Hydrophobic fluid is then stored in the trauma container 21 and hydrophilic fluid is stored in the inner container 22.
  • the hydrophobic fluid is moved along the trauma fluid inlet tube 30 to the trauma fluid inlet 51 of the first channel 50, and the hydrophilic fluid is along the inner channel fluid inlet tube 40. It moves to the inner phase fluid inlet (54).
  • the hydrophobic fluid moved to the first channel 50 is moved to the lamination section 56 along the first branch pipe 52 and the second branch pipe 53, and the hydrophilic fluid is along the inner phase fluid moving pipe 55. It moves to the lamination part 56. That is, the hydrophobic fluid and the hydrophilic fluid meet each other at the lamination portion 56 of the first channel 50 and pass through the orifice 58.
  • the hydrophilic fluid is dispersed into small particles in the hydrophobic fluid (emulsification phenomenon). In other words, an emulsifying material is formed in which the hydrophobic fluid surrounds the hydrophilic fluid.
  • the emulsified material having passed through the orifice 58 is moved along the emulsified material moving tube 57. This process results in the formation of water in oil (W / O) emulsion particles in which oil is dispersed in water (see FIG. 3B).
  • the first channel 50 in particular, the emulsifier moving tube 57 may be made of a hydrophobic material or the inner wall of the first channel 50 may be coated with a hydrophobic material.
  • the emulsifying material has a configuration in which the outside is made of a hydrophobic fluid and the hydrophilic fluid is dispersed therein, when the emulsifying material moving tube 57 is made of a hydrophobic material, the hydrophobic fluid portion of the emulsifying material is formed into an emulsifying material moving tube ( 57) to the inner wall. Therefore, the above W / O emulsified particles can be smoothly moved along the emulsified material moving tube 57 while maintaining its shape and structure.
  • the W / O emulsified particles passing through the first emulsifier material passage 59 of the first channel 50 are moved to the second channel 80 stacked on the first channel 50. Specifically, the W / O emulsified particles are formed along the second channel 80 along the second emulsifier channel 84 of the second channel 80 in communication with the first emulsifier channel 59 of the first channel 50. Is moved to.
  • the second emulsifier passageway 84 is a portion corresponding to the inner phase fluid inlet 54 of the first channel 50, and the W / O emulsified particles moved through the second emulsifier passageway 84 may cause an internal wound of the multiple formulation. Is achieved. That is, the W / O emulsified particles introduced into the second channel 80 through the second emulsifier passage 81 are moved to the multiple formulation lamination 86 along the emulsifier piping 86.
  • the outermost fluid is moved from the outermost container 45 to the outermost fluid inlet 81 formed in the second channel 80 through the outermost fluid inlet pipe 46.
  • the outermost fluid forms the trauma of the multiple formulation.
  • the outermost fluid may be a hydrophilic fluid having a similar range or substantially the same hydrophilicity as the inner wound fluid. That is, the outermost fluid is a hydrophilic fluid so that the prepared multiple formulation can cover the hydrophilic fluid on the outer surface of the W / O emulsified particles to have both the moisturizing effect of the W / O emulsified particles and the fresh feeling of the O / W emulsified particles. Can be.
  • the outermost fluid introduced into the second channel 80 is moved to the multiple formulation lamination 86 along the outermost fluid transfer branch tubes 82 and 83 of the second channel 80. Therefore, the emulsion and the outermost fluid having passed through the multiple formulation laminations 86 are in contact with each other and the W / O emulsified particles and the outermost fluid in the orifice 57a to produce W / O / W emulsion particles (FIG. 5B). Reference).
  • the W / O / W emulsified particles produced according to this process are moved to the multiple formulation outlet 88 through the multiple formulation transfer tube 87.
  • the second channel 80 in particular, the multiple dosage form moving tube 87 may be made of a hydrophilic material or coated with an inner wall of the hydrophilic material.
  • the multiple formulation is made of a hydrophilic fluid on the outside, when the multiple formulation transfer tube 87 is made of a hydrophilic material, the hydrophilic fluid portion of the emulsion material is attracted to the inner wall of the emulsion transfer tube 57. Therefore, the above W / O / W emulsified particles can be smoothly moved along the multiple formulation moving tube 87 while maintaining its shape and structure.
  • the W / O / W emulsified particles moved along the multiple formulation outlet 88 may be discharged to the user through the inlet of the pump 70 through the tube 60.
  • FIG. 6 An example of the W / O / W emulsion particles produced according to the above process is shown in FIG. 6. Specifically, Figure 6 shows an experimental example of the W / O / W emulsion particles.
  • the present invention since the multiple formulations are produced by the user's pump operation and the external discharge of the multiple formulations is made, there is an advantage that the production and supply of the multiple formulations can be performed at the time required by the user. .
  • the manufacturing process is very simple and the prepared formulations also have the advantage of maintaining a stable state.
  • the present invention relates to an apparatus for preparing cosmetic compositions containing multiple formulations instantaneously emulsified on the basis of microfluidic channels, which is applicable to the cosmetic industry.

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PCT/KR2017/011066 2016-09-30 2017-09-29 미세 유체 채널에 기반하여 순간 유화된 멀티플 제형을 함유하는 화장품 조성물 제조 장치 WO2018062971A1 (ko)

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JP2000189244A (ja) * 1998-12-01 2000-07-11 L'oreal Sa 多相組成物を分配するための装置、この種の装置の使用および使用方法
KR20100086779A (ko) * 2009-01-23 2010-08-02 경원대학교 산학협력단 나노필터 구조체를 포함하는 화장품 용기
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