WO2018062876A3 - 통증이 경감되는 골관절염 치료용 키트 - Google Patents

통증이 경감되는 골관절염 치료용 키트 Download PDF

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WO2018062876A3
WO2018062876A3 PCT/KR2017/010766 KR2017010766W WO2018062876A3 WO 2018062876 A3 WO2018062876 A3 WO 2018062876A3 KR 2017010766 W KR2017010766 W KR 2017010766W WO 2018062876 A3 WO2018062876 A3 WO 2018062876A3
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osteoarthritis
kit
treatment
stem cells
mesenchymal stem
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PCT/KR2017/010766
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English (en)
French (fr)
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WO2018062876A2 (ko
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조미라
김석중
이선영
이승훈
나현식
문수진
권지예
정경아
김은경
김선애
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가톨릭대학교 산학협력단
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Publication of WO2018062876A2 publication Critical patent/WO2018062876A2/ko
Publication of WO2018062876A3 publication Critical patent/WO2018062876A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 STAT3 억제제가 처리된 간엽줄기세포를 유효성분으로 포함하는 정맥내 투여용 조성물; 및 간엽줄기세포를 유효성분으로 포함하는 관절강내 투여용 조성물을 포함하는 통증이 경감되는 골관절염 치료용 키트 및 이를 이용한 골관절염 예방 및 치료 방법에 관한 것으로, STAT3 억제제가 처리된 간엽줄기세포를 정맥내 투여하고 동시에 간엽줄기세포를 관절강내 투여함으로써 골관절염의 통증을 경감시키면서도 치료할 수 있다.
PCT/KR2017/010766 2016-09-27 2017-09-27 통증이 경감되는 골관절염 치료용 키트 WO2018062876A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20160123831 2016-09-27
KR10-2016-0123831 2016-09-27

Publications (2)

Publication Number Publication Date
WO2018062876A2 WO2018062876A2 (ko) 2018-04-05
WO2018062876A3 true WO2018062876A3 (ko) 2018-08-09

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PCT/KR2017/010766 WO2018062876A2 (ko) 2016-09-27 2017-09-27 통증이 경감되는 골관절염 치료용 키트

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KR (1) KR101969229B1 (ko)
WO (1) WO2018062876A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102275313B1 (ko) * 2019-02-12 2021-07-09 전남대학교산학협력단 Dec1의 발현 및 활성 조절 물질을 포함하는 관절염 예방 또는 치료용 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130111448A (ko) * 2012-03-29 2013-10-10 가톨릭대학교 산학협력단 간엽줄기세포를 포함하는 자가면역질환 치료용 조성물
KR20150020113A (ko) * 2013-08-16 2015-02-25 가톨릭대학교 산학협력단 mTOR/STAT3 신호억제제 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물
KR20150044679A (ko) * 2013-10-17 2015-04-27 엘지이노텍 주식회사 광학계 및 이를 포함하는 카메라 모듈
WO2016001845A1 (en) * 2014-06-30 2016-01-07 Tigenix S.A.U. Mesenchymal stromal cells for treating rheumatoid arthritis
KR20170000802A (ko) * 2015-06-24 2017-01-03 가톨릭대학교 산학협력단 Stat3 억제제가 처리된 간엽줄기세포를 유효성분으로 포함하는 골관절염의 예방 또는 치료용 세포치료제 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101273747B1 (ko) 2010-09-09 2013-06-12 가톨릭대학교 산학협력단 Ｓｔａ-21을 유효성분으로 함유하는 관절염의 예방 및 치료용 조성물
WO2014038882A1 (ko) 2012-09-07 2014-03-13 한국생명공학연구원 신규 화합물 및 이의 인터루킨-1베타 또는 인터루킨-6 저해 용도
KR101659158B1 (ko) * 2013-08-16 2016-09-23 가톨릭대학교 산학협력단 메트포민이 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물
KR101705412B1 (ko) * 2014-06-17 2017-02-09 가톨릭대학교 산학협력단 Stat3 억제제가 처리된 간엽줄기세포를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130111448A (ko) * 2012-03-29 2013-10-10 가톨릭대학교 산학협력단 간엽줄기세포를 포함하는 자가면역질환 치료용 조성물
KR20150020113A (ko) * 2013-08-16 2015-02-25 가톨릭대학교 산학협력단 mTOR/STAT3 신호억제제 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물
KR20150044679A (ko) * 2013-10-17 2015-04-27 엘지이노텍 주식회사 광학계 및 이를 포함하는 카메라 모듈
WO2016001845A1 (en) * 2014-06-30 2016-01-07 Tigenix S.A.U. Mesenchymal stromal cells for treating rheumatoid arthritis
KR20170000802A (ko) * 2015-06-24 2017-01-03 가톨릭대학교 산학협력단 Stat3 억제제가 처리된 간엽줄기세포를 유효성분으로 포함하는 골관절염의 예방 또는 치료용 세포치료제 조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEE, S.-Y. ET AL.: "IL -17-mediated Bcl-2 Expression Regulates Survival of Fibroblast-like Synoviocytes in Rheumatoid Arthritis through STAT3 Activation", ARTHRITIS RESEARCH & THERAPY, vol. 15, no. R31, 2013, pages 1 - 10, XP021146259 *
YOON, JIN SUN: "Role of STAT3 in Immunoregulatory Function of Human Bone Marrow-derived Mesenchymal Stem Cells", DOCTORAL THESI S, 2009, pages 1 - 71 *

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Publication number Publication date
WO2018062876A2 (ko) 2018-04-05
KR20180034291A (ko) 2018-04-04
KR101969229B1 (ko) 2019-04-15

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