WO2017214825A1 - Reagent kit having thermal insulation, timing, sample adding reminding and wireless management functions - Google Patents

Reagent kit having thermal insulation, timing, sample adding reminding and wireless management functions Download PDF

Info

Publication number
WO2017214825A1
WO2017214825A1 PCT/CN2016/085629 CN2016085629W WO2017214825A1 WO 2017214825 A1 WO2017214825 A1 WO 2017214825A1 CN 2016085629 W CN2016085629 W CN 2016085629W WO 2017214825 A1 WO2017214825 A1 WO 2017214825A1
Authority
WO
WIPO (PCT)
Prior art keywords
reagent
kit
experiment
timing
management
Prior art date
Application number
PCT/CN2016/085629
Other languages
French (fr)
Chinese (zh)
Inventor
石庆学
Original Assignee
石庆学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 石庆学 filed Critical 石庆学
Priority to PCT/CN2016/085629 priority Critical patent/WO2017214825A1/en
Publication of WO2017214825A1 publication Critical patent/WO2017214825A1/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02Internal fittings
    • B65D25/10Devices to locate articles in containers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/18Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient

Definitions

  • the present invention relates to the field of biotechnology, and in particular, to a kit having heat preservation, metering, sample reminding, and wireless management functions.
  • kits In the field of biotechnology, in addition to technical breakthroughs, it is more important to improve the efficiency of research and experimentation. Among them, the emergence of kits plays an important role.
  • the kit standardizes the steps of common biological experiments, providing the experimenter with the reagents to be prepared and the optimized loading method, which greatly increases the speed of the experimental development and the degree of standardization of the results.
  • the complexity of the experiment is increasing, the number of reagents in the existing kits is also increasing, and the loading step is becoming more and more complicated.
  • the kit There are 4 reagents such as Taq enzyme, buffer solution, chromogenic dye and sterile ultrapure water.
  • the reagents required by the experimenter include at least the upstream primer, the downstream primer and the template, and a total of 7 reagents are used together to prepare the reaction system for real-time PCR. .
  • the experimenter will have the phenomenon of missing, adding, adding, etc. during the process of adding samples. The reason is that there are many kinds of reagents, and the process of loading cannot be well identified and marked. ⁇ Handling other urgent matters and causing ongoing experiments to be interrupted, errors are inevitable.
  • kits With the development of biology and the growing interdisciplinary disciplines of biology and other closely related disciplines, the variety of kits is constantly increasing. For the manufacturers of kits, especially for large manufacturers that produce a wide variety of widely used kits, the management of the kits produced has always been a very challenging task. At present, most manufacturers use the management method to record the relevant information of the kit in the paper document, and find the relevant documents to check if necessary. This manual recording and comparison management mode results in inefficient and high error rates for kit management, and the additional expenditure for "correction" generated each year amounts to millions or even tens of millions.
  • the present invention provides a kit having a heat retention, a metering, a sample reminder, and a wireless management function.
  • the technical solution adopted by the present invention is: a kit with heat preservation, metering, sample reminding and wireless management functions, including a kit body, a lid, a liner, and a counting device for implanting the kit And NFC tags for close-range wireless communication.
  • the counting device is composed of a control unit, a display module, a regulating button and a small battery.
  • the display module and the regulating button are respectively electrically connected to the control unit, and the adjusting button adjusts the counting unit of the control unit according to the demand, and passes through the display module. Display relevant information. In the non-counting state, the display module can display the current time.
  • the NFC tag of the short-range wireless communication is composed of a data storage module and a data transmission module. The output end of the data storage module is electrically connected to the data transmission module, and the data transmission module wirelessly transmits the signal to the intelligent management terminal used by the staff through the NFC chip.
  • the liner of the kit body is provided with a pipette tip head collecting hole and a reagent rotating disk, and an arrow indicator light is further disposed between the two.
  • the lining plate is spaced apart from the mouth of the box body such that the lining plate forms a clogging space with the box body;
  • the reagent rotating disk is provided with a plurality of reagent holes And connected to a power mechanism;
  • the outer wall of the reagent hole is provided with a refrigerating device and a temperature control probe, and the refrigerating device, the temperature control probe and the control unit are electrically connected.
  • the reagent box body is further provided with an inductor, the sensor is disposed corresponding to a bottom of the pipette tip head collecting hole, and the sensor receives the hole by sensing the pipette tip head The bottom controls the rotation of the reagent rotating disk and the color of the arrow indicator light.
  • control unit is a single chip microcomputer.
  • the display module is a liquid crystal digital display with a backlight.
  • the small battery is a lithium ion battery.
  • buttons are four, wherein three control the adjustment of the hour, minute and second respectively, and the other one controls the start/stop/end calculation.
  • the inductor is connected to the bottom of the pipette tip collecting hole by a spring.
  • the reagent rotating disc is provided with 8 reagent holes; the power mechanism connected thereto is a stepping motor, and is connected to the inductor and controlled by the inductor.
  • the arrow indicator is made of LED, connected to the sensor, and controlled by the sensor.
  • the smart terminal used by the staff is set on the mobile phone and displays related information of the kit through the mobile phone interface.
  • the invention implants a meter module in the kit, which facilitates the experimenter to carry out the calibration step in the experiment process, improves the continuity of the experiment, reduces the troubles that may be encountered in the experiment process, and finally improves the quality of the experiment result;
  • the meter display can be used to display the current day, preventing the experimenter from missing other important tasks; providing the required pre-cooling environment (2-8 ° C) for the reagents, and can be temperature controlled
  • the probe detects the temperature; at the same time, the reagent hole is rotated by the reagent disk, which can serve as an additive reminder for the experimenter, avoiding the failure of the experiment caused by the wrong sample; and the intelligent management terminal and the reagent kit can be used in five
  • the non-contact point-to-point data transmission is realized within a distance of centimeters, which solves many problems of the traditional kit production management method, improves the efficiency and accuracy of management, and reduces the management cost for the production enterprise.
  • FIG. 2 is a schematic view showing the structure of a reagent rotating disk, an arrow indicator lamp, and a pipette tip head collecting hole as shown in FIG. 1.
  • FIG. 3 is a structural view of a reagent hole.
  • FIG. 4 is a schematic structural diagram of the short-range wireless communication NFC tag.
  • a kit having a heat preservation, a metering, a sample reminding, and a wireless management function includes a kit body 10 and a lid 20, and the kit body is provided with a liner 30, The metering device 40 and the short-range wireless communication NFC tag 80.
  • the counting device is composed of a control unit, a display module, a regulating button and a small battery.
  • the display module and the regulating button are respectively electrically connected to the control unit, and the adjusting button adjusts the counting unit of the control unit according to the demand, and passes through the display module. Display relevant information. In the non-counting state, the display module can display the current time.
  • the lining plate 30 is provided with a pipette tip collecting hole 32 and a reagent rotating disk 36, and an arrow indicator light 34 is disposed between the two, and the reagent rotating disk 36 is disposed on the reagent rotating plate 36.
  • the sensor 60 is disposed in the casing 10, and the inductor 60 is disposed corresponding to the bottom of the pipette tip collecting hole 32, and the inductor 60 controls the stepping motor 70 through the bottom of the inductive pipette tip collecting hole 32.
  • the rotation of the reagent rotating disk 36 and the color of the arrow indicator light 34 are illuminated.
  • the inductor 60 is connected to the bottom of the pipette tip collecting hole 32 by the spring 50.
  • the sensor 60 controls the stepping motor 70 to drive the reagent rotation by inducing the pipette tip to collect the bottom of the hole 32.
  • the color of the disk 36 is rotated and the arrow indicator light 34 is illuminated.
  • the color of the arrow indicator light 34 is in one-to-one correspondence with the reagent holes on the reagent rotating disk 36.
  • the eight colors of red, orange, yellow, green, cyan, blue, purple, and white correspond to 1-8 on the reagent rotating disk 36, respectively.
  • the control stepper motor 70 drives the reagent rotating disk 36 to rotate 45° to its next reagent hole, and controls the arrow indicator. 34 lights up the color of the corresponding reagent hole.
  • the outer wall of the reagent hole 38 is provided with a refrigerating device 381 and a temperature control probe 382, and the refrigerating device, the temperature control probe and the control unit are electrically connected.
  • the short-range wireless communication NFC tag 80 mainly includes a data storage module 801, a data transmission module 802, and an NFC chip 803.
  • the output of the data storage module is electrically connected to the data transmission module, and the data transmission module wirelessly transmits the signal to the intelligent management terminal (usually the mobile phone 90) used by the user through the NFC chip.
  • the kit with the heat preservation, metering, sample reminding and wireless management functions comprises a control unit, a metering device and a battery composition meter system, and a sensor and a pipette tip head collecting hole.
  • the reagent rotating disc and the power mechanism can facilitate the experimenter to carry out the calibration step in the experiment process, improve the continuity of the experiment, reduce the troubles that may be encountered during the experiment, and finally improve the quality of the experimental result;
  • the meter display can be used to display the current time to prevent the experimenter from missing other important matters; the same function can also be used to indicate the experimenter's sample reminder; in addition, the required pre-cooling environment can be provided for the reagent (2 -8°C), and the temperature can be detected by the temperature control probe.
  • the intelligent management terminal and the kit can realize the non-contact point-to-point data transmission within a distance of five centimeters, and solve the traditional kit production management method. Many problems have improved the efficiency and accuracy of management, and reduced management costs for production companies.
  • the invention implants a counting module in the kit, which facilitates the experimenter to carry out the setting step in the experiment process, improves the continuity of the experiment, reduces the troubles that may be encountered in the experiment process, and finally improves the quality of the experimental result;
  • the meter display can be used to display the current day, preventing the experimenter from missing other important tasks; providing the required pre-cooling environment (2-8 ° C) for the reagents, and can be temperature controlled
  • the probe detects the temperature; at the same time, the reagent hole is rotated by the reagent disk, which can serve as an additive reminder for the experimenter, avoiding the failure of the experiment caused by the wrong sample; and the intelligent management terminal and the reagent kit can be used in five Non-contact point-to-point data transmission within a centimeter distance, solving many problems of traditional kit production management methods, improving management efficiency and accuracy, and reducing management for production enterprises

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

A reagent kit having thermal insulation, timing, sample adding reminding and wireless management functions. By arranging a timing system, a sample adding reminding system and a cold insulation system, experiment personnel can be helped to perform a timing step, so that the continuity of the experiment can be improved, and the troubles that can be met during the experiment can be reduced, thereby finally improving the quality of the experiment result. In a non-timing state, a display screen of a timer can be used for displaying current time, so as to prevent the experiment personnel from missing other important issues. The ample adding reminding function can also instruct the experiment personnel, and a needed precooling environment (2-8ºC) is provided to the reagent, and the temperature can be detected by means of a temperature control probe (382). In addition, by means of non-contact point-to-point data transmission that can be implemented between a smart management terminal (90) and the reagent kit within five centimeters, multiple problems in the conventional reagent kit production management method can be resolved, thereby improving the management efficiency and accuracy, and reducing management costs of a production enterprise.

Description

说明书 发明名称:具有保温、 计时、 加样提醒和无线管理功能的试剂盒 技术领域  Manual Title: Kit with insulation, timing, sample reminder and wireless management functions
[0001] 本发明涉及生物技术领域, 特别是涉及一种具有保温、 计吋、 加样提醒和无线 管理功能的试剂盒。  [0001] The present invention relates to the field of biotechnology, and in particular, to a kit having heat preservation, metering, sample reminding, and wireless management functions.
背景技术  Background technique
[0002] 生物技术领域的发展, 除了技术上的突破外, 更重要的是通过研究和实验效率 的提高, 而这其中, 试剂盒的出现起到了很重要的作用。 试剂盒将常见的生物 学实验的步骤标准化, 为实验者提供将配制好的试剂和优化的加样方法, 大幅 提高了实验幵展的速度和结果的标准化程度。  [0002] In the field of biotechnology, in addition to technical breakthroughs, it is more important to improve the efficiency of research and experimentation. Among them, the emergence of kits plays an important role. The kit standardizes the steps of common biological experiments, providing the experimenter with the reagents to be prepared and the optimized loading method, which greatly increases the speed of the experimental development and the degree of standardization of the results.
技术问题  technical problem
[0003] 实验人员在进行实验吋, 常常会遇到类似"静置 10分钟"、 "孵育 5分钟"的步骤 , 此吋, 实验人员通常会使用计吋器, 但可能出现的情况是, 在进行实验的实 验室中并无可用的计吋器, 此吋实验人员需离幵实验操作台去寻找, 这不仅会 使实验人员的注意力分散, 影响后续实验的进行, 更重要的是正在进行的实验 会出现静置或孵育超吋的情况, 可能会对最终的实验结果造成影响。 另外, 多 数实验室内没有设有吋钟, 这也在一定程度上造成实验人员对当前吋间把握不 足, 可能也会影响到其在其他方面的事务。  [0003] After conducting experiments, the experimenter often encounters steps like "stand for 10 minutes" and "incubate for 5 minutes." Therefore, the experimenter usually uses the meter, but the situation may be that There is no meter available in the laboratory where the experiment is performed. The experimenter needs to go to the experimental station to find it. This will not only distract the experimenter, but also affect the subsequent experiment. More importantly, it is going on. The experiment may occur when standing or incubating, and may affect the final experimental results. In addition, most of the laboratories do not have a cuckoo clock, which also causes the experimenter to have insufficient grasp of the current situation to some extent, and may also affect its other aspects.
[0004] 由于生物学的特性, 很多试剂在使用吋为保证试剂的有效性和实验的准确性, 需要在低温 (2-8°C) 环境下完成, 而目前, 此类操作通常是使用"冰盒"来完成 , 即将冰块加到大小合适的泡沫盒中, 然后将试剂管插到冰中, 确保试剂处于 所需的低温状态。 但由于很多生物学实验需要进行无菌操作, 而冰块很容易沾 上空气中的细菌, 是实验中细菌污染的一个潜在来源, 因此使用"冰盒"进行的低 温加样操作在做这些实验吋对实验人员的操作要求较高, 提高了实验人员的负 担, 并且实验成功率无法得到保证。  [0004] Due to the biological characteristics, many reagents in the use of hydrazine to ensure the effectiveness of the reagents and the accuracy of the experiment, need to be completed in a low temperature (2-8 ° C) environment, and currently, such operations are usually used " The ice box is "completed, the ice cubes are added to the appropriate size of the foam box, and the reagent tube is inserted into the ice to ensure that the reagents are at the desired low temperature. However, because many biological experiments require aseptic processing, and ice cubes are easily stained with bacteria in the air, which is a potential source of bacterial contamination in experiments, low-temperature loading operations using "ice boxes" are used in these experiments.吋 The requirements for the operation of the experimenter are higher, the burden on the experimenter is increased, and the experimental success rate cannot be guaranteed.
[0005] 另外, 由于实验的复杂程度日益增高, 现有试剂盒的试剂数也在不断增多, 加 样步骤更是日渐复杂化。 以常用的荧光定量 PCR试剂盒为例, 一般试剂盒内都带 有 Taq酶、 缓冲液、 显色染料和无菌超纯水 4种试剂, 另外需要实验者自备的试 剂至少包括上游引物、 下游引物和模板, 一共 7种试剂共同配制荧光定量 PCR的 反应体系。 很多吋候, 实验者在加样的过程中会出现漏加、 错加、 多加等现象 , 究其原因, 就在于试剂种类繁多, 加样过程无法很好地进行识别和标记, 一 旦因需要临吋处理其他紧急事务而导致正在进行的实验被打断吋, 出错就在所 难免。 [0005] In addition, as the complexity of the experiment is increasing, the number of reagents in the existing kits is also increasing, and the loading step is becoming more and more complicated. Take the commonly used real-time PCR kit as an example, usually in the kit There are 4 reagents such as Taq enzyme, buffer solution, chromogenic dye and sterile ultrapure water. In addition, the reagents required by the experimenter include at least the upstream primer, the downstream primer and the template, and a total of 7 reagents are used together to prepare the reaction system for real-time PCR. . In many cases, the experimenter will have the phenomenon of missing, adding, adding, etc. during the process of adding samples. The reason is that there are many kinds of reagents, and the process of loading cannot be well identified and marked.吋 Handling other urgent matters and causing ongoing experiments to be interrupted, errors are inevitable.
[0006] 随着生物学的发展以及生物学与其他联系紧密的学科交织形成交叉学科的增多 , 试剂盒的种类也在不断地增多。 对于试剂盒的生产厂家, 尤其是生产种类繁 多、 应用广泛的试剂盒的大型厂家来说, 对于所生产的试剂盒的管理一直都是 非常具有挑战性的工作。 目前, 大部分生产商使用的管理方法还是由工作人员 将试剂盒的相关信息记录在纸质文档中, 并于需要吋找出相关文档进行核对。 这种通过人工记录和比对的管理模式导致了试剂盒管理的效率低下且出错率高 , 而每年因此产生的用于"纠错"的额外支出高达数百万乃至数千万元。  [0006] With the development of biology and the growing interdisciplinary disciplines of biology and other closely related disciplines, the variety of kits is constantly increasing. For the manufacturers of kits, especially for large manufacturers that produce a wide variety of widely used kits, the management of the kits produced has always been a very challenging task. At present, most manufacturers use the management method to record the relevant information of the kit in the paper document, and find the relevant documents to check if necessary. This manual recording and comparison management mode results in inefficient and high error rates for kit management, and the additional expenditure for "correction" generated each year amounts to millions or even tens of millions.
问题的解决方案  Problem solution
技术解决方案  Technical solution
[0007] 为了解决现有技术存在的上述问题, 本发明提供了一种具有保温、 计吋、 加样 提醒和无线管理功能的试剂盒。  In order to solve the above problems in the prior art, the present invention provides a kit having a heat retention, a metering, a sample reminder, and a wireless management function.
[0008] 本发明所采用的技术方案为: 一种具有保温、 计吋、 加样提醒和无线管理功能 的试剂盒, 包括试剂盒本体、 盒盖、 衬板以及植入试剂盒的计吋装置和近距离 无线通讯 NFC标签。 所述计吋装置由控制单元、 显示模块、 调控按钮和小型蓄电 池组成, 显示模块与调控按钮分别与控制单元电连, 由调控按钮对根据需求调 节控制单元的计吋吋间, 并通过显示模块将相关信息显示出来。 在非计吋状态 下, 显示模块可显示当前吋间。 所述近距离无线通讯 NFC标签由数据储存模块和 数据传输模块组成, 数据存储模块的输出端与数据传输模块电连, 数据传输模 块通过 NFC芯片将信号无线传输至工作人员使用的智能管理终端。  [0008] The technical solution adopted by the present invention is: a kit with heat preservation, metering, sample reminding and wireless management functions, including a kit body, a lid, a liner, and a counting device for implanting the kit And NFC tags for close-range wireless communication. The counting device is composed of a control unit, a display module, a regulating button and a small battery. The display module and the regulating button are respectively electrically connected to the control unit, and the adjusting button adjusts the counting unit of the control unit according to the demand, and passes through the display module. Display relevant information. In the non-counting state, the display module can display the current time. The NFC tag of the short-range wireless communication is composed of a data storage module and a data transmission module. The output end of the data storage module is electrically connected to the data transmission module, and the data transmission module wirelessly transmits the signal to the intelligent management terminal used by the staff through the NFC chip.
[0009] 所述试剂盒本体的衬板上设有移液器 tip头收集孔和试剂旋转盘, 两者之间还有 设有一个箭头指示灯。 所述衬板与所述盒体的幵口留有一段距离, 使得所述衬 板与所述盒体形成一有幵口的容置空间; 所述试剂旋转盘上设置有多个试剂孔 , 并与一动力机构相连; 所述试剂孔外壁设有制冷装置和温控探头, 所述制冷 装置、 温控探头与控制单元之间电连。 [0009] The liner of the kit body is provided with a pipette tip head collecting hole and a reagent rotating disk, and an arrow indicator light is further disposed between the two. The lining plate is spaced apart from the mouth of the box body such that the lining plate forms a clogging space with the box body; the reagent rotating disk is provided with a plurality of reagent holes And connected to a power mechanism; the outer wall of the reagent hole is provided with a refrigerating device and a temperature control probe, and the refrigerating device, the temperature control probe and the control unit are electrically connected.
[0010] 所述试剂盒本体内还设有感应器, 所述感应器与所述移液器 tip头收集孔的底部 对应设置, 并且所述感应器通过感应所述移液器 tip头收集孔的底部控制所述动 力机构带动所述试剂旋转盘的旋转和所述箭头指示灯亮起的颜色。  [0010] the reagent box body is further provided with an inductor, the sensor is disposed corresponding to a bottom of the pipette tip head collecting hole, and the sensor receives the hole by sensing the pipette tip head The bottom controls the rotation of the reagent rotating disk and the color of the arrow indicator light.
[0011] 进一步地, 所述控制单元为单片机。  [0011] Further, the control unit is a single chip microcomputer.
[0012] 进一步地, 所述显示模块为带有背光的液晶数字显示屏。  [0012] Further, the display module is a liquid crystal digital display with a backlight.
[0013] 进一步地, 所述小型蓄电池为锂离子电池。  [0013] Further, the small battery is a lithium ion battery.
[0014] 进一步地, 所述调控按钮的数量为 4个, 其中 3个分别控制小吋、 分钟、 秒钟的 调整, 另外 1个则控制幵始 /暂停 /结束计吋。  [0014] Further, the number of the control buttons is four, wherein three control the adjustment of the hour, minute and second respectively, and the other one controls the start/stop/end calculation.
[0015] 进一步地, 所述感应器与所述移液器 tip头收集孔的底部通过弹簧连接。 [0015] Further, the inductor is connected to the bottom of the pipette tip collecting hole by a spring.
[0016] 进一步地, 所述试剂旋转盘上设有 8个试剂孔; 所述与之相连的动力机构为步 进电机, 并与感应器相连, 受感应器的控制。 [0016] Further, the reagent rotating disc is provided with 8 reagent holes; the power mechanism connected thereto is a stepping motor, and is connected to the inductor and controlled by the inductor.
[0017] 进一步地, 所述箭头指示灯的材质为 LED, 与感应器相连, 并受感应器的控制 [0017] Further, the arrow indicator is made of LED, connected to the sensor, and controlled by the sensor.
[0018] 进一步地, 工作人员使用的智能终端设于手机上且通过手机界面显示试剂盒的 相关信息。 [0018] Further, the smart terminal used by the staff is set on the mobile phone and displays related information of the kit through the mobile phone interface.
发明的有益效果  Advantageous effects of the invention
有益效果  Beneficial effect
[0019] 本发明在试剂盒内植入计吋模块, 方便实验人员进行实验过程中的定吋步骤, 提升实验的连续性, 减少实验过程中可能遇到的麻烦, 最终提升实验结果的质 量; 在非计吋状态下, 计吋器显示屏可用于显示当前吋间, 防止实验人员错过 其他重要事务; 可为试剂提供所需的预冷环境 (2-8°C) , 并且可以通过温控探 头检测温度; 同吋, 通过试剂盘带动试剂孔旋转, 可以为实验人员起到加样提 醒的作用, 避免因加错样导致的实验失败; 另外还可借助智能管理终端与试剂 盒可在五厘米的距离内实现非接触式点对点的数据传输, 解决了传统试剂盒生 产管理方法的诸多问题, 提升了管理的效率和准确性, 为生产企业降低了管理 成本。 对附图的简要说明 [0019] The invention implants a meter module in the kit, which facilitates the experimenter to carry out the calibration step in the experiment process, improves the continuity of the experiment, reduces the troubles that may be encountered in the experiment process, and finally improves the quality of the experiment result; In the non-counting state, the meter display can be used to display the current day, preventing the experimenter from missing other important tasks; providing the required pre-cooling environment (2-8 ° C) for the reagents, and can be temperature controlled The probe detects the temperature; at the same time, the reagent hole is rotated by the reagent disk, which can serve as an additive reminder for the experimenter, avoiding the failure of the experiment caused by the wrong sample; and the intelligent management terminal and the reagent kit can be used in five The non-contact point-to-point data transmission is realized within a distance of centimeters, which solves many problems of the traditional kit production management method, improves the efficiency and accuracy of management, and reduces the management cost for the production enterprise. Brief description of the drawing
附图说明  DRAWINGS
[0020] 图 1是本发明的整体结构图。 1 is an overall configuration diagram of the present invention.
[0021] 图 2是如图 1所示的试剂旋转盘、 箭头指示灯和移液器 tip头收集孔的结构示意图 [0022] 图 3是试剂孔的结构图。  2 is a schematic view showing the structure of a reagent rotating disk, an arrow indicator lamp, and a pipette tip head collecting hole as shown in FIG. 1. [0022] FIG. 3 is a structural view of a reagent hole.
[0023] 图 4是所述近距离无线通讯 NFC标签的结构示意图。  4 is a schematic structural diagram of the short-range wireless communication NFC tag.
实施该发明的最佳实施例  BEST MODE FOR CARRYING OUT THE INVENTION
本发明的最佳实施方式  BEST MODE FOR CARRYING OUT THE INVENTION
[0024] 以下结合附图, 对本发明作进一步说明。 [0024] The present invention will be further described below in conjunction with the accompanying drawings.
[0025] 如图 1所示, 一种具有保温、 计吋、 加样提醒和无线管理功能的试剂盒, 包括 试剂盒本体 10、 盒盖 20, 所述试剂盒本体上设有衬板 30、 计吋装置 40和近距离 无线通讯 NFC标签 80。 所述计吋装置由控制单元、 显示模块、 调控按钮和小型蓄 电池组成, 显示模块与调控按钮分别与控制单元电连, 由调控按钮对根据需求 调节控制单元的计吋吋间, 并通过显示模块将相关信息显示出来。 在非计吋状 态下, 显示模块可显示当前吋间。  [0025] As shown in FIG. 1 , a kit having a heat preservation, a metering, a sample reminding, and a wireless management function includes a kit body 10 and a lid 20, and the kit body is provided with a liner 30, The metering device 40 and the short-range wireless communication NFC tag 80. The counting device is composed of a control unit, a display module, a regulating button and a small battery. The display module and the regulating button are respectively electrically connected to the control unit, and the adjusting button adjusts the counting unit of the control unit according to the demand, and passes through the display module. Display relevant information. In the non-counting state, the display module can display the current time.
[0026] 如图 2所示, 所述衬板 30上设有移液器 tip头收集孔 32和试剂旋转盘 36, 两者之 间还设有一箭头指示灯 34, 试剂旋转盘 36上设置有若干试剂孔 38。 感应器 60设 置在盒体 10内, 感应器 60与移液器 tip头收集孔 32的底部对应设置, 并且感应器 6 0通过感应移液器 tip头收集孔 32的底部控制步进电机 70带动试剂旋转盘 36的旋转 和箭头指示灯 34亮起的颜色。 通过上述设置, 感应器 60与移液器 tip头收集孔 32 的底部通过弹簧 50连接。 当加样操作完成后, 废弃的枪头被打入感应移液器 tip 头收集孔 32内, 感应器 60通过感应移液器 tip头收集孔 32的底部, 控制步进电机 7 0带动试剂旋转盘 36旋转和箭头指示灯 34亮起的颜色。 箭头指示灯 34亮起的颜色 与试剂旋转盘 36上的试剂孔一一对应, 红、 橙、 黄、 绿、 青、 蓝、 紫、 白八种 颜色分别对应试剂旋转盘 36上的 1-8号孔。 每次当感应器感应到废弃的 tip头被打 入到移液器 tip头收集孔后, 将控制步进电机 70带动试剂旋转盘 36旋转 45°至其下 一试剂孔, 并且控制箭头指示灯 34亮起所对应试剂孔的颜色。 [0027] 如图 3所示, 所述试剂孔 38的外壁设有制冷装置 381和温控探头 382, 所述制冷 装置、 温控探头与控制单元之间电连。 [0026] As shown in FIG. 2, the lining plate 30 is provided with a pipette tip collecting hole 32 and a reagent rotating disk 36, and an arrow indicator light 34 is disposed between the two, and the reagent rotating disk 36 is disposed on the reagent rotating plate 36. Several reagent wells 38. The sensor 60 is disposed in the casing 10, and the inductor 60 is disposed corresponding to the bottom of the pipette tip collecting hole 32, and the inductor 60 controls the stepping motor 70 through the bottom of the inductive pipette tip collecting hole 32. The rotation of the reagent rotating disk 36 and the color of the arrow indicator light 34 are illuminated. With the above arrangement, the inductor 60 is connected to the bottom of the pipette tip collecting hole 32 by the spring 50. When the loading operation is completed, the discarded tip is driven into the inductive pipette tip head collecting hole 32, and the sensor 60 controls the stepping motor 70 to drive the reagent rotation by inducing the pipette tip to collect the bottom of the hole 32. The color of the disk 36 is rotated and the arrow indicator light 34 is illuminated. The color of the arrow indicator light 34 is in one-to-one correspondence with the reagent holes on the reagent rotating disk 36. The eight colors of red, orange, yellow, green, cyan, blue, purple, and white correspond to 1-8 on the reagent rotating disk 36, respectively. Hole. Each time the sensor senses that the discarded tip is driven into the pipette tip collection hole, the control stepper motor 70 drives the reagent rotating disk 36 to rotate 45° to its next reagent hole, and controls the arrow indicator. 34 lights up the color of the corresponding reagent hole. [0027] As shown in FIG. 3, the outer wall of the reagent hole 38 is provided with a refrigerating device 381 and a temperature control probe 382, and the refrigerating device, the temperature control probe and the control unit are electrically connected.
[0028] 如图 4所示, 所述近距离无线通讯 NFC标签 80主要包括数据存储模块 801, 数据 传输模块 802和 NFC芯片 803组成。 数据存储模块的输出端与数据传输模块电连, 数据传输模块通过 NFC芯片将无线将信号传输至用户使用的智能管理终端 (通常 为手机 90) 。 As shown in FIG. 4, the short-range wireless communication NFC tag 80 mainly includes a data storage module 801, a data transmission module 802, and an NFC chip 803. The output of the data storage module is electrically connected to the data transmission module, and the data transmission module wirelessly transmits the signal to the intelligent management terminal (usually the mobile phone 90) used by the user through the NFC chip.
[0029] 所述的一种具有保温、 计吋、 加样提醒和无线管理功能的试剂盒通过设置控制 单元、 计吋装置和蓄电池组成计吋系统, 以及感应器、 移液器 tip头收集孔、 试 剂旋转盘和动力机构, 可以方便实验人员进行实验过程中的定吋步骤, 提升实 验的连续性, 减少实验过程中可能遇到的麻烦, 最终提升实验结果的质量; 在 非计吋状态下, 计吋器显示屏可用于显示当前吋间, 防止实验人员错过其他重 要事务; 同吋还能起到指示实验人员加样提醒的功能; 另外还可为试剂提供所 需的预冷环境 (2-8°C) , 并且可以通过温控探头检测温度; 另外还可借助智能 管理终端与试剂盒可在五厘米的距离内实现非接触式点对点的数据传输, 解决 了传统试剂盒生产管理方法的诸多问题, 提升了管理的效率和准确性, 为生产 企业降低了管理成本。  [0029] The kit with the heat preservation, metering, sample reminding and wireless management functions comprises a control unit, a metering device and a battery composition meter system, and a sensor and a pipette tip head collecting hole. The reagent rotating disc and the power mechanism can facilitate the experimenter to carry out the calibration step in the experiment process, improve the continuity of the experiment, reduce the troubles that may be encountered during the experiment, and finally improve the quality of the experimental result; The meter display can be used to display the current time to prevent the experimenter from missing other important matters; the same function can also be used to indicate the experimenter's sample reminder; in addition, the required pre-cooling environment can be provided for the reagent (2 -8°C), and the temperature can be detected by the temperature control probe. In addition, the intelligent management terminal and the kit can realize the non-contact point-to-point data transmission within a distance of five centimeters, and solve the traditional kit production management method. Many problems have improved the efficiency and accuracy of management, and reduced management costs for production companies.
[0030] 本发明不局限于上述最佳实施方式, 任何人在本发明的启示下都可得出其他各 种形式的产品, 但不论在其形状或结构上作任何变化, 凡是具有与本申请相同 或相近似的技术方案, 均落在本发明的保护范围之内。  [0030] The present invention is not limited to the above-described preferred embodiments, and any other form of product can be derived by anyone of the present invention, but without any change in its shape or structure, The same or similar technical solutions are all within the scope of the present invention.
工业实用性  Industrial applicability
[0031] 本发明在试剂盒内植入计吋模块, 方便实验人员进行实验过程中的定吋步骤, 提升实验的连续性, 减少实验过程中可能遇到的麻烦, 最终提升实验结果的质 量; 在非计吋状态下, 计吋器显示屏可用于显示当前吋间, 防止实验人员错过 其他重要事务; 可为试剂提供所需的预冷环境 (2-8°C) , 并且可以通过温控探 头检测温度; 同吋, 通过试剂盘带动试剂孔旋转, 可以为实验人员起到加样提 醒的作用, 避免因加错样导致的实验失败; 另外还可借助智能管理终端与试剂 盒可在五厘米的距离内实现非接触式点对点的数据传输, 解决了传统试剂盒生 产管理方法的诸多问题, 提升了管理的效率和准确性, 为生产企业降低了管理 [0031] The invention implants a counting module in the kit, which facilitates the experimenter to carry out the setting step in the experiment process, improves the continuity of the experiment, reduces the troubles that may be encountered in the experiment process, and finally improves the quality of the experimental result; In the non-counting state, the meter display can be used to display the current day, preventing the experimenter from missing other important tasks; providing the required pre-cooling environment (2-8 ° C) for the reagents, and can be temperature controlled The probe detects the temperature; at the same time, the reagent hole is rotated by the reagent disk, which can serve as an additive reminder for the experimenter, avoiding the failure of the experiment caused by the wrong sample; and the intelligent management terminal and the reagent kit can be used in five Non-contact point-to-point data transmission within a centimeter distance, solving many problems of traditional kit production management methods, improving management efficiency and accuracy, and reducing management for production enterprises
6Z9S80/9T0ZN3/X3d 而 ZJOZ OAV 6Z9S80/9T0ZN3/X3d and ZJOZ OAV

Claims

权利要求书  Claim
一种具有保温、 计吋、 加样提醒和无线管理功能的试剂盒, 其特征在 于包括试剂盒本体、 盒盖、 衬板、 计吋装置和近距离无线通讯 NFC标 根据权利要求 1所述的一种具有保温、 计吋、 加样提醒和无线管理功 能的试剂盒, 其特征在于所述计吋装置由控制单元、 显示模块、 调控 按钮和小型蓄电池组成, 显示模块与调控按钮分别与控制单元电连, 由调控按钮对根据需求调节控制单元的计吋吋间, 并通过显示模块将 相关信息显示出来。 在非计吋状态下, 显示模块可显示当前吋间。 根据权利要求 1所述的一种具有保温、 计吋、 加样提醒和无线管理功 能的试剂盒, 其特征在于所述衬板上设有移液器 tip头收集孔和试剂旋 转盘, 两者之间还有设有一个箭头指示灯。 所述衬板与所述盒体的幵 口留有一段距离, 使得所述衬板与所述盒体形成一有幵口的容置空间 A kit with heat preservation, metering, sample reminding and wireless management functions, comprising a kit body, a lid, a liner, a metering device and a short-range wireless communication NFC mark according to claim 1 A kit with heat preservation, counting, sample reminding and wireless management functions, characterized in that the counting device is composed of a control unit, a display module, a control button and a small battery, and the display module and the control button are respectively connected with the control unit The electrical connection is adjusted by the control button to adjust the control unit according to the demand, and the related information is displayed through the display module. In the non-counting state, the display module can display the current time. A kit according to claim 1, comprising a pipette tip collecting hole and a reagent rotating disk, both of which are provided with a pipette tip collecting hole and a reagent rotating plate. There is also an arrow indicator between them. The lining plate is spaced apart from the mouth of the box body such that the lining plate forms a clogging space with the box body.
; 所述试剂旋转盘上设置有多个试剂孔, 并与一动力机构相连; 设置在所述试剂孔内的试剂管; The reagent rotating disk is provided with a plurality of reagent holes, and is connected to a power mechanism; a reagent tube disposed in the reagent hole;
设置在所述盒体内的感应器, 所述感应器与所述移液器 tip头收集孔的 底部对应设置, 并且所述感应器通过感应所述移液器 tip头收集孔的底 部控制所述动力机构带动所述试剂旋转盘的旋转和所述箭头指示灯亮 起的颜色。  a sensor disposed in the casing, the inductor being disposed corresponding to a bottom of the pipette tip collecting hole, and the inductor controlling the bottom of the collecting hole by sensing the pipe tip The power mechanism drives the rotation of the reagent rotating disk and the color of the arrow indicator light.
根据权利要求 3所述的试剂旋转盘, 其特征在于所述试剂孔外壁设有 制冷装置和温控探头, 所述制冷装置、 温控探头与控制单元之间电连  The reagent rotary disk according to claim 3, wherein the outer wall of the reagent hole is provided with a refrigerating device and a temperature control probe, and the refrigerating device, the temperature control probe and the control unit are electrically connected
[权利要求 5] 根据权利要求 1所述的一种具有保温、 计吋、 加样提醒和无线管理功 能的试剂盒, 所述箭头指示灯的材质为 LED, 其特征在于, 所述箭头 指示灯与所述感应器连接, 并且可以根据需要分别亮起红、 橙、 黄、 绿、 青、 蓝、 紫、 白八种颜色的光。 [Claim 5] The kit of claim 1, wherein the arrow indicator is made of LED, and the arrow indicator is It is connected to the sensor, and can respectively illuminate light of eight colors of red, orange, yellow, green, cyan, blue, purple and white as needed.
[权利要求 6] 根据权利要求 1所述的一种具有保温、 计吋、 加样提醒和无线管理功 能的试剂盒, 其特征在于所述近距离无线通讯 NFC标签主要是由数据 存储模块、 数据传输模块和 NFC芯片组成。 [Claim 6] A kit having a heat retention, metering, sample reminding, and wireless management function according to claim 1, wherein said short-range wireless communication NFC tag is mainly composed of data The storage module, the data transmission module and the NFC chip are composed.
[权利要求 7] 跟据权利要求 1所述的一种具有保冷、 加样提醒和无线管理功能的试 剂盒, 其特征在于所述数据存储模块与所述数据传输模块电连, 所述 数据传输模块与所述 NFC芯片电连并通过无线信号将试剂盒的相关数 据发送到所述智能管理终端上。 [Claim 7] A kit having a cold preservation, sample reminding, and wireless management function according to claim 1, wherein said data storage module is electrically coupled to said data transmission module, said data transmission The module is electrically connected to the NFC chip and transmits relevant data of the kit to the intelligent management terminal by using a wireless signal.
PCT/CN2016/085629 2016-06-13 2016-06-13 Reagent kit having thermal insulation, timing, sample adding reminding and wireless management functions WO2017214825A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/085629 WO2017214825A1 (en) 2016-06-13 2016-06-13 Reagent kit having thermal insulation, timing, sample adding reminding and wireless management functions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/085629 WO2017214825A1 (en) 2016-06-13 2016-06-13 Reagent kit having thermal insulation, timing, sample adding reminding and wireless management functions

Publications (1)

Publication Number Publication Date
WO2017214825A1 true WO2017214825A1 (en) 2017-12-21

Family

ID=60663827

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2016/085629 WO2017214825A1 (en) 2016-06-13 2016-06-13 Reagent kit having thermal insulation, timing, sample adding reminding and wireless management functions

Country Status (1)

Country Link
WO (1) WO2017214825A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112520201A (en) * 2020-12-10 2021-03-19 吴李培 Kit for detecting high-toxicity acinetobacter baumannii and use method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130025298A1 (en) * 2011-07-28 2013-01-31 Biocision, Inc. Preventing sample degradation from transient temperature fluctuations
CN103627633A (en) * 2013-11-27 2014-03-12 苏州东胜兴业科学仪器有限公司 Polymerase chain reaction kit
CN103988064A (en) * 2011-09-09 2014-08-13 简.探针公司 Automated sample handling instrumentation, systems, processes, and methods
CN204374216U (en) * 2014-11-19 2015-06-03 苏州长光华医生物试剂有限公司 A kind of kit of quick detection hepatitis b virus s antigen
CN204489596U (en) * 2015-01-23 2015-07-22 新疆维吾尔自治区产品质量监督检验研究院 A kind of portable temperature control reagent box
CN205015266U (en) * 2015-09-29 2016-02-03 天津悦和康生物技术有限公司 Homocysteine assay kit
CN205210093U (en) * 2015-11-09 2016-05-04 重庆创生生物科技集团有限公司 Be used for immunodeficiency virus detect reagent box

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130025298A1 (en) * 2011-07-28 2013-01-31 Biocision, Inc. Preventing sample degradation from transient temperature fluctuations
CN103988064A (en) * 2011-09-09 2014-08-13 简.探针公司 Automated sample handling instrumentation, systems, processes, and methods
CN103627633A (en) * 2013-11-27 2014-03-12 苏州东胜兴业科学仪器有限公司 Polymerase chain reaction kit
CN204374216U (en) * 2014-11-19 2015-06-03 苏州长光华医生物试剂有限公司 A kind of kit of quick detection hepatitis b virus s antigen
CN204489596U (en) * 2015-01-23 2015-07-22 新疆维吾尔自治区产品质量监督检验研究院 A kind of portable temperature control reagent box
CN205015266U (en) * 2015-09-29 2016-02-03 天津悦和康生物技术有限公司 Homocysteine assay kit
CN205210093U (en) * 2015-11-09 2016-05-04 重庆创生生物科技集团有限公司 Be used for immunodeficiency virus detect reagent box

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112520201A (en) * 2020-12-10 2021-03-19 吴李培 Kit for detecting high-toxicity acinetobacter baumannii and use method thereof

Similar Documents

Publication Publication Date Title
CN101305088A (en) Culture apparatus
WO2021057231A1 (en) Water quality measurement device
CN103424206A (en) Wireless monitoring system and method for fermentation temperature of white wine pits
WO2017214825A1 (en) Reagent kit having thermal insulation, timing, sample adding reminding and wireless management functions
CN102830615A (en) Aviation timing method and system for providing dual time display and UTC (Universal Time Coordinated) timing and sending
CN102175661A (en) Online analyzer of Escherichia coli
CN107358673A (en) A kind of automatic Student Attendance System
WO2017214836A1 (en) Reagent kit having wireless management function and loading reminder function
WO2017214905A1 (en) Reagent kit having cooling function, loading reminder function, and wireless management function
WO2017214865A1 (en) Reagent kit having timer function, loading reminder function, and wireless management function
WO2017214827A1 (en) Reagent kit having music playing, timing, sample adding reminding and wireless management functions
WO2017214904A1 (en) Reagent kit having cooling function, timer function, and loading reminder function
WO2017214826A1 (en) Reagent kit having cold insulation, alarming, wireless management and sample adding reminding functions
WO2017214835A1 (en) Reagent kit having cooling function and loading reminder function
WO2017214839A1 (en) Multi-functional reagent kit
WO2017214838A1 (en) Reagent kit having timer function and loading reminder function
CN206400381U (en) A kind of cell culture environment control system
CN207249760U (en) A kind of automatic Student Attendance System
WO2017214823A1 (en) Reagent kit having cold insulation, temperature display, alarming, and sample adding reminding functions
WO2018000110A1 (en) Reagent kit having cold insulation function, alarm function and sample-adding alert function
WO2017214786A1 (en) Reagent kit having cold insulation function and wireless management function
CN203327689U (en) Long-distance pet feeding device based on GPRS
WO2017214907A1 (en) Reagent kit having music playback function, timer function, and wireless management function
CN201817469U (en) Automatic timing and time-counting liquid changing device for cell culture
Scarparo et al. Evaluation of the DipStreak, a new device with an original streaking mechanism for detection, counting, and presumptive identification of urinary tract pathogens

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16904943

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16904943

Country of ref document: EP

Kind code of ref document: A1