WO2017166565A1 - Synergistic plant growth regulator composition - Google Patents

Synergistic plant growth regulator composition Download PDF

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Publication number
WO2017166565A1
WO2017166565A1 PCT/CN2016/094029 CN2016094029W WO2017166565A1 WO 2017166565 A1 WO2017166565 A1 WO 2017166565A1 CN 2016094029 W CN2016094029 W CN 2016094029W WO 2017166565 A1 WO2017166565 A1 WO 2017166565A1
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WIPO (PCT)
Prior art keywords
choline chloride
composition
active component
thiabendazole
composition according
Prior art date
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PCT/CN2016/094029
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French (fr)
Chinese (zh)
Inventor
仲汉根
季红进
Original Assignee
江苏辉丰农化股份有限公司
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Publication of WO2017166565A1 publication Critical patent/WO2017166565A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A01N37/22—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A01N37/22—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides
    • A01N37/24—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides containing at least one oxygen or sulfur atom being directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom

Definitions

  • the invention belongs to the field of agricultural plant protection, in particular to a plant growth regulator composition with improved properties, in particular to a composition comprising thidiazuron and choline chloride pesticide.
  • Choline chloride is also a plant photosynthesis promoter, which has a significant effect on increasing yield.
  • Spraying wheat and rice at the booting stage can promote the differentiation of spikelets and multi-tassel grains. Spraying at the filling stage can accelerate the filling rate, and the spikes are full, which can promote the 1000-grain weight increase.
  • It can also be used to increase the yield of corn, sugar cane, sweet potato, potato, radish, onion, cotton, tobacco, vegetables, grapes, mango, etc., and the effect is stable under different climatic and ecological environment conditions; the underground growth crops such as roots are applied at the initial stage of expansion, The effect of swelling and increasing yield is obvious; ornamental plants azalea, poinsettia, geranium, hibiscus and so on regulate growth; wheat, barley, oats are lodging resistance.
  • Pyraclostrobin is a new type of high-efficiency plant growth regulator. When it is absorbed by plants, it can promote the separation of petioles and stems and form natural shedding. It can be widely used in pesticides and fertilizers. It has strong biological activity, and its ability to induce plant cell division and callus formation is many times higher than that of general cytokinins. Improve crop absorptive capacity and increase photosynthesis, so as to increase production and enhance the purpose. It can be used in various kinds of melons, fruits, vegetables, seedlings, flowers, food, tobacco and other crops, and can also be used for tissue culture, genetic engineering, etc. In production, it can significantly improve crop yield, improve quality and use less, has no pollution to the ecological environment, and is non-toxic to humans, animals, birds, bees and natural enemies.
  • the plant growth regulators currently on the market are mainly based on a single agent, and the effect is single.
  • the inventors have found that choline chloride and thiabendazole have significant synergistic effects in regulating or promoting plant growth.
  • Another object of the present invention is to provide a process for the preparation of a composition comprising two active ingredients A and B plant growth regulators and for regulating and promoting the growth of crops in the agricultural field.
  • the object of the invention can be achieved by the following measures:
  • a synergistic plant growth regulator composition comprising two active components A and B, Wherein the active component A is thiabendazole, and the active component B is choline chloride or a derivative thereof, and the weight ratio between the two components is 1:0.02 of the active component A and the active component B. 500.
  • the weight ratio of the active component A to the active component B is 1:0.02 to 480, and the weight ratio may be further preferably 1:0.03 to 450 in order to make the effect more remarkable.
  • the weight ratio between the two components of A and B can be arbitrarily adjusted within the range of the following ratios: 1:0.02, 1:0.03, 1:0.04, 1:0.05, 1: 0.06, 1:0.07, 1:0.08, 1:0.09, 1:0.1, 1:0.2, 1:0.3, 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:20, 1:30, 1: 40, 1:50, 1:60, 1:70, 1:80, 1:90, 1:100, 1:150, 1:200, 1:250, 1:300, 1:350, 1:400, 1:410, 1:420, 1:430, 1:440, 1:450, 1:460, 1:470 or 1:480, and can also be selected within the range of any two of the above ratios.
  • Common choline chloride derivatives include chlorinated choline chloride and the like.
  • composition of the present invention is used for better regulating the growth of crops, promoting the improvement of crop health and quality, and improving crop yield; it can be applied to the agricultural field to promote or regulate plant growth.
  • the present invention provides the use of a composition comprising component A (thiabendazole) and component B (choline chloride or a derivative thereof) for regulating crop growth in the agricultural field, in particular for regulating crops in rice, wheat or fruit trees. Use for growth and other aspects of disease resistance.
  • component A thiabendazole
  • component B choline chloride or a derivative thereof
  • the composition of the present invention can be made into a pesticide-approved dosage form from active ingredients and auxiliaries, in particular, it can be combined with other pesticides (such as fungicides, insecticides, herbicides, plant growth regulators). Mixtures, fertilizers, etc. are used in combination, and these are mixed with commonly used pesticides or fertilizers disclosed in the prior art.
  • the composition of the present invention can also be used in combination with other pesticides (such as fungicides, insecticides, herbicides, plant growth regulators), fertilizers, etc., and these are mixed with Commonly used pesticides or fertilizers disclosed in the art.
  • composition of the present invention can be processed into a preparation of various dosage forms with a fertilizer, or co-administered or mixed with a fertilizer.
  • Suitable fertilizers include one or more of a large number of elements such as nitrogen, phosphorus, potassium, or the like, or one or more trace elements of copper, iron, manganese, zinc, boron, calcium, magnesium, sulfur, or the like, or A mixture of one or both of humic acid, amino acid or chitosan.
  • composition may specifically comprise an agrochemical auxiliary, such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, etc., during the application process.
  • an agrochemical auxiliary such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, etc.
  • an agrochemical auxiliary such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, etc.
  • Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers. .
  • the active ingredient may be present in the composition in an amount of from 0.5 to 95%, preferably from 0.5 to 80%, more preferably from 1 to 50%.
  • the method of application of the compositions of the invention comprises the use of the compositions of the invention for aerial parts of plants, in particular leaves or foliage. You can choose to soak or apply to the surface of the control object.
  • the frequency of administration and the amount administered will depend on the biological and climatic conditions of the pathogen.
  • the plant growth site such as rice fields, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant. In vivo (systemic action).
  • compositions may be applied only with the active ingredient or may be mixed with an additive (agrochemical adjuvant).
  • composition of the present invention can be prepared into a pesticide-acceptable dosage form such as a liquid, a suspension, a soluble liquid, an oil suspension, a microcapsule, a microemulsion, a wettable powder and the like.
  • a pesticide-acceptable dosage form such as a liquid, a suspension, a soluble liquid, an oil suspension, a microcapsule, a microemulsion, a wettable powder and the like.
  • the compositions may be applied by spraying, misting, dusting, spreading or pouring, and the like.
  • Microcapsule dosage forms suitable for the present invention include: microcapsule suspension, microcapsule suspension-suspension, microcapsule suspension-water emulsion, etc., characterized in that the inner wall of the capsule (ie, the capsule core) contains choline chloride and thiophene as active ingredients.
  • the benzophenone is mixed in a certain proportion, that is, the two are mixed into a microcapsule.
  • the microcapsules are stably dispersed and suspended in a certain concentration to form a microcapsule suspending agent in water as a continuous phase.
  • one of the active ingredients is prepared as a microcapsule suspension, another active ingredient is prepared into an emulsion, and the prepared two components are mixed, stirred, and shaken to obtain a microcapsule suspension-suspension or microcapsule suspension.
  • Agent-water emulsion is a microcapsule suspension.
  • composition of the present invention can be prepared into various dosage forms by a known method, and the active ingredient and the auxiliary agent, such as a solvent, a solid carrier, and, if necessary, can be uniformly mixed and ground together with the surfactant to prepare a desired preparation. Dosage form.
  • the above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • aromatic hydrocarbons preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
  • Alkenes or paraffins, alcohols and glycols and their ethers and esters such as ethanol, ethylene glycol, ethylene glycol monomethyl
  • ketones such as cyclohexanone
  • highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide
  • vegetable or vegetable oils such as soybean oil.
  • the above solid carriers are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay.
  • a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand.
  • a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
  • Suitable surfactants are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene poly
  • Plants in the present invention include, but are not limited to, corn, wheat, rice, and the like.
  • the two active ingredients in the compositions of the present invention exhibit synergistic effects, the activity of which is more pronounced than the expected sum of activity using a single compound, and the individual activity of a single compound.
  • Other characteristics exhibited by the composition of the present invention are mainly as follows: 1.
  • the composition of the present invention has a significant synergistic effect; 2. Due to the large difference in the chemical structure of the two single agents of the composition, the effect The mechanism is completely different, there is no cross-resistance, which can delay the resistance problem caused by the two single agents alone; 3.
  • the composition of the invention can well regulate crop growth, improve disease resistance and stress resistance, and promote crop health effects. To increase crop yields.
  • the active ingredients choline chloride and thidiazepine, and the components such as dispersant, wetting agent, thickener and water are uniformly mixed according to the formula, and after sanding and/or high-speed shearing, semi-finished products are obtained. After the analysis, the water is mixed and evenly filtered to obtain the finished product.
  • Example 1 5.1% thidiazuron choline chloride suspension
  • Example 2 30.06% thiabendazole ⁇ chlorinated choline chloride suspension
  • Example 3 2.08% thidiazuron choline chloride suspension
  • Example 4 22.55% thidiazuron choline chloride suspension
  • the active ingredient thiablon and choline chloride are mixed in a certain ratio, that is, the two are mixed to form a microcapsule.
  • the microcapsules are stably dispersed and suspended in a certain concentration to form a microcapsule suspending agent in water as a continuous phase.
  • one of the active ingredients is prepared as a microcapsule suspension, another active ingredient is prepared into an emulsion, and the prepared two components are mixed, stirred, and shaken to obtain a microcapsule suspension-suspension or microcapsule suspension.
  • Agent-water emulsion Agent-water emulsion.
  • Example 5 1% thiabendazole ⁇ chlorinated choline microcapsule suspension
  • Example 6 25.1% thidiazuron choline chloride microcapsule suspension
  • Example 7 15.3% thidiazuron choline chloride microcapsule suspension
  • Example 8 30.1% thiabendazole ⁇ choline chloride sac suspension-suspending agent
  • Example 9 40.2% thidiazuron choline chloride microcapsule suspension
  • the active ingredient thiablon and choline chloride are placed in an enamel kettle according to a certain ratio of mixture, surfactant, auxiliary agent and water, and stirred under water bath conditions until a transparent liquid is obtained, that is, a soluble liquid agent is obtained.
  • Example 11 40.1% thiabendazole ⁇ choline chloride soluble solution
  • the active ingredient and the auxiliary agent are added to the reaction kettle, and the balance is made up with water and stirred uniformly to obtain a thiabendazole-choline chloride aqueous solution.
  • Example 12 10.4% thiabendazole-choline chloride aqueous solution
  • Example 13 45.3% thiabendazole-choline chloride aqueous solution
  • Example 14 38% thiabendazole-choline chloride aqueous solution
  • Example 15 20.2% thiabendazole-choline chloride aqueous solution
  • Example 16 52.65% thiabendazole-choline chloride aqueous solution
  • the thiabendazole and choline chloride were diluted with acetone at a certain concentration, and the crops were sprayed with stems and leaves.
  • the effects of various concentrations on the growth of the crops were determined in the field, including the plant height, plant diameter, root length and disease resistance of the crops. Comprehensive evaluation of fruit quality, yield, etc.
  • Plant height control rate (clear water control plant height - treated plant height) / clear water control plant height * 100%
  • stem diameter of clear water control plant - stem diameter of treated plant stem diameter of clear water control plant *100%
  • Grain 1000-grain weight increase rate (1000-grain weight of fresh water control - 1000-grain weight of treated grain) / 1000-grain weight of fresh water control *100%
  • the invention can effectively increase the plant diameter of the corn, improve the nutrient conduction capacity of the plant, and can improve the lodging resistance of the corn growth by promoting the plant diameter.
  • thiabendone has a certain disease resistance and anti-reverse effect on plant growth when used as a single agent, while choline chloride can inhibit C 3 photosynthesis in plants, promote root growth and development, and have certain immunity to crop diseases.
  • the invention can effectively regulate the control of the corn, that is, reduce the plant height and the ear position of the corn, and effectively balance the vegetative growth and the reproductive growth. To prevent lodging; 4, due to the synergistic effect of thiazolone and choline chloride in the early stage of corn growth, promote the nutrient transmission, disease resistance and resistance of maize plants.
  • the 1000-grain weight of corn and the yield per mu are significant.
  • the promotion effect of the yield per mu is up to 19.9%; 5, when the ratio of thidiazepine to choline chloride is 1: (25-150), the synergistic effect of the two is obvious.
  • the ratio of thiabendazole to choline chloride is lower than 25 or higher than 150, the synergistic effect of the two is not obvious.
  • the experimental data from Table 2 shows that the product of the present invention is applied during the flowering stage of barley, and can effectively regulate the healthy growth of barley.
  • the main performances are as follows: 1. It can increase the ear length of barley and increase the number of grains per spike; 2. It can significantly increase the weight of barley grain; 3. Thiabendazole can promote the growth of barley, while choline chloride can affect barley. Growth has certain resistance to disease and stress, and the two have a synergistic effect after compounding; 4.
  • the composition of the invention has a significant effect on the unit yield of barley.

Abstract

Provided is a synergistic plant growth regulator composition. The effective ingredients of the composition comprise active components A and B, wherein the active component A is thidiazuron, and the active component B is choline chloride and a derivative thereof; and the weight ratio of the active component A to the active component B is 1:0.02-500. Also provided is the use of the composition. Experimental results indicate that the composition can effectively regulate the growth of crops, increase the disease resistance and stress resistance thereof, promote the health of crops and increase the yield of crops.

Description

具有增效作用的植物生长调节剂组合物Synergistic plant growth regulator composition 技术领域Technical field
本发明属于农业植物保护领域，特别是涉及一种具有改进性能的植物生长调节剂组合物，具体地说是涉及一种包含噻苯隆和氯化胆碱农药的组合物。The invention belongs to the field of agricultural plant protection, in particular to a plant growth regulator composition with improved properties, in particular to a composition comprising thidiazuron and choline chloride pesticide.
背景技术Background technique
氯化胆碱还是一种植物光合作用促进剂，对增加产量有明显的效果。小麦、水稻在孕穗期喷施可促进小穗分化，多结穗粒，灌浆期喷施可加快灌浆速度，穗粒饱满，能促进千粒重显著增加。亦可用于玉米、甘蔗、甘薯、马铃薯、萝卜、洋葱、棉花、烟草、蔬菜、葡萄、芒果等增加产量，在不同气候、生态环境条件下效果稳定；块根等地下部分生长作物在膨大初期施用，膨大增产效果明显；观赏植物杜鹃花、一品红、天竺葵、木槿等调节生长；小麦、大麦、燕麦抗倒伏。Choline chloride is also a plant photosynthesis promoter, which has a significant effect on increasing yield. Spraying wheat and rice at the booting stage can promote the differentiation of spikelets and multi-tassel grains. Spraying at the filling stage can accelerate the filling rate, and the spikes are full, which can promote the 1000-grain weight increase. It can also be used to increase the yield of corn, sugar cane, sweet potato, potato, radish, onion, cotton, tobacco, vegetables, grapes, mango, etc., and the effect is stable under different climatic and ecological environment conditions; the underground growth crops such as roots are applied at the initial stage of expansion, The effect of swelling and increasing yield is obvious; ornamental plants azalea, poinsettia, geranium, hibiscus and so on regulate growth; wheat, barley, oats are lodging resistance.
噻苯隆(pyraclostrobin)是新型高效植物生长调节剂，噻苯隆被植物吸收后，可促进叶柄与茎之间的分离组织，形成自然脱落，在农药、肥料中可被广泛应用。它具有极强的生物活性，其诱导植物细胞分裂、愈伤组织形成的能力比一般细胞分裂素高许多倍。提高作物吸收能力，增加光合作用，从而达到增产、增优目的。可用于各类瓜、果、蔬菜、苗木、花卉、粮食、烟草等作物，还可用于组织培养、基因工程等。在生产上能显著提高作物产量、改善品质且有用量少、对生态环境无污染，对人、畜、鸟、蜜蜂、天敌无毒等特点。Pyraclostrobin is a new type of high-efficiency plant growth regulator. When it is absorbed by plants, it can promote the separation of petioles and stems and form natural shedding. It can be widely used in pesticides and fertilizers. It has strong biological activity, and its ability to induce plant cell division and callus formation is many times higher than that of general cytokinins. Improve crop absorptive capacity and increase photosynthesis, so as to increase production and enhance the purpose. It can be used in various kinds of melons, fruits, vegetables, seedlings, flowers, food, tobacco and other crops, and can also be used for tissue culture, genetic engineering, etc. In production, it can significantly improve crop yield, improve quality and use less, has no pollution to the ecological environment, and is non-toxic to humans, animals, birds, bees and natural enemies.
目前市面上销售的植物生长调节剂主要是以单剂为主，且作用效果单一。The plant growth regulators currently on the market are mainly based on a single agent, and the effect is single.
发明内容Summary of the invention
本发明的目的是提供一种具有增效作用的植物生长调节剂组合物，以促进作物生长，提高作物的抗病和作物产量。发明人发现，氯化胆碱与噻苯隆两者之间在调节或促进植物生长方面具有显著的协同增效作用。It is an object of the present invention to provide a synergistic plant growth regulator composition for promoting crop growth and improving crop disease resistance and crop yield. The inventors have found that choline chloride and thiabendazole have significant synergistic effects in regulating or promoting plant growth.
本发明的另一个目的是提供包含两种有效成分A和B植物生长调节剂组合物的制备方法及在农业领域调节和促进农作物生长的应用。Another object of the present invention is to provide a process for the preparation of a composition comprising two active ingredients A and B plant growth regulators and for regulating and promoting the growth of crops in the agricultural field.
本发明的目的可以通过以下措施达到：The object of the invention can be achieved by the following measures:
一种具有增效作用的植物生长调节剂组合物，该组合物包含A和B两种活性组分， 其中活性组分A为噻苯隆，活性组分B为氯化胆碱或其衍生物，两组分之间的重量比为活性组分A和活性组分B的重量比为1：0.02～500。A synergistic plant growth regulator composition comprising two active components A and B, Wherein the active component A is thiabendazole, and the active component B is choline chloride or a derivative thereof, and the weight ratio between the two components is 1:0.02 of the active component A and the active component B. 500.
在一种优选方案中，活性组分A和活性组分B的重量比为为1：0.02～480，为使作用效果更明显两者重量比可进一步优选1：0.03～450。In a preferred embodiment, the weight ratio of the active component A to the active component B is 1:0.02 to 480, and the weight ratio may be further preferably 1:0.03 to 450 in order to make the effect more remarkable.
在一种优选的方案中，A和B两组分之间的重量比可以任意地在下述配比的范围内进行调整：1：0.02、1：0.03、1：0.04、1：0.05、1：0.06、1：0.07、1：0.08、1：0.09、1：0.1、1：0.2、1：0.3、1：0.4、1：0.5、1：0.6、1：0.7、1：0.8、1：0.9、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：20、1：30、1：40、1：50、1：60、1：70、1：80、1：90、1：100、1：150、1：200、1：250、1：300、1：350、1：400、1：410、1：420、1：430、1：440、1：450、1：460、1：470或1：480，也可以在以上任意两个配比所组成的范围内进行选择。In a preferred embodiment, the weight ratio between the two components of A and B can be arbitrarily adjusted within the range of the following ratios: 1:0.02, 1:0.03, 1:0.04, 1:0.05, 1: 0.06, 1:0.07, 1:0.08, 1:0.09, 1:0.1, 1:0.2, 1:0.3, 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:20, 1:30, 1: 40, 1:50, 1:60, 1:70, 1:80, 1:90, 1:100, 1:150, 1:200, 1:250, 1:300, 1:350, 1:400, 1:410, 1:420, 1:430, 1:440, 1:450, 1:460, 1:470 or 1:480, and can also be selected within the range of any two of the above ratios.
常见的氯化胆碱衍生物包括氯代氯化胆碱等。Common choline chloride derivatives include chlorinated choline chloride and the like.
发明人通过试验发现，本发明的组合物是用于可以更好的调节作物的生长，促进作物健康作用和品质的提升，提高作物产量；它可应用于农业领域促进或调节植物生长方面。The inventors have found through experiments that the composition of the present invention is used for better regulating the growth of crops, promoting the improvement of crop health and quality, and improving crop yield; it can be applied to the agricultural field to promote or regulate plant growth.
本发明提供了包含组分A(噻苯隆)和组分B(氯化胆碱或其衍生物)的组合物在农业领域调节农作物生长的用途，特别是在水稻、小麦或果树方面调节作物生长提高抗病效果等方面的用途。The present invention provides the use of a composition comprising component A (thiabendazole) and component B (choline chloride or a derivative thereof) for regulating crop growth in the agricultural field, in particular for regulating crops in rice, wheat or fruit trees. Use for growth and other aspects of disease resistance.
为充分发挥本发明的优势效果，本发明的组合物可以由活性成分和助剂制成农药上允许的剂型，特别是可以与其他农药(如杀菌剂、杀虫剂、除草剂、植物生长调节剂)、肥料等混合使用，这些与之混用的均为现有技术公开的常用的农药或肥料。为充分发挥本发明的优势效果，本发明的组合物还可以与其他农药(如杀菌剂、杀虫剂、除草剂、植物生长调节剂)、肥料等混合使用，这些与之混用的均为现有技术公开的常用的农药或肥料。In order to give full play to the advantageous effects of the present invention, the composition of the present invention can be made into a pesticide-approved dosage form from active ingredients and auxiliaries, in particular, it can be combined with other pesticides (such as fungicides, insecticides, herbicides, plant growth regulators). Mixtures, fertilizers, etc. are used in combination, and these are mixed with commonly used pesticides or fertilizers disclosed in the prior art. In order to fully exert the advantageous effects of the present invention, the composition of the present invention can also be used in combination with other pesticides (such as fungicides, insecticides, herbicides, plant growth regulators), fertilizers, etc., and these are mixed with Commonly used pesticides or fertilizers disclosed in the art.
为提高使用效果，本发明的组合物可以与肥料加工成各种剂型的制剂，或与肥料共同施用或混用。合适的肥料如含有氮、磷、钾等中的一种或几种大量元素，或含有铜、铁、锰、锌、硼、钙、镁、硫等中的一种或几种微量元素，或含有腐殖酸、氨基酸或甲壳胺等肥料的一种或两种的混合物。In order to enhance the use effect, the composition of the present invention can be processed into a preparation of various dosage forms with a fertilizer, or co-administered or mixed with a fertilizer. Suitable fertilizers include one or more of a large number of elements such as nitrogen, phosphorus, potassium, or the like, or one or more trace elements of copper, iron, manganese, zinc, boron, calcium, magnesium, sulfur, or the like, or A mixture of one or both of humic acid, amino acid or chitosan.
上述组合物具体可包含农药助剂，例如载体、溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂等中的一种或几种，在施用的过程中可以混合常用的助剂。The above composition may specifically comprise an agrochemical auxiliary, such as one or more of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, etc., during the application process. Mix commonly used auxiliaries.
合适的助剂可以是固体或液体，它们通常是剂型加工过程中常用的物质，例如天然的或再生的矿物质，溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂或肥料。 Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers. .
本发明的组合物中，活性成分在组合物中的质量含量可以达到0.5～95％，优选0.5～80％，进一步优选1～50％。In the composition of the present invention, the active ingredient may be present in the composition in an amount of from 0.5 to 95%, preferably from 0.5 to 80%, more preferably from 1 to 50%.
本发明组合物的施用方法包括将本发明的组合物用于植物生长的地上部分，特别是叶部或叶面。可以选择浸种或涂抹于防治对象表面。施用的频率和施用量取决于病原体的生物学和气候生存条件。可以将植物的生长场所，如稻田，用组合物的液体制剂浸湿，或者将组合物以固体形式施用于土壤中，如以颗粒形式(土壤施用)，组合物可以由土壤经植物根部进入植物体内(内吸作用)。The method of application of the compositions of the invention comprises the use of the compositions of the invention for aerial parts of plants, in particular leaves or foliage. You can choose to soak or apply to the surface of the control object. The frequency of administration and the amount administered will depend on the biological and climatic conditions of the pathogen. The plant growth site, such as rice fields, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant. In vivo (systemic action).
这些组合物可以仅仅包含活性成分进行施用，也可以与添加剂(农药助剂)一起混合使用。These compositions may be applied only with the active ingredient or may be mixed with an additive (agrochemical adjuvant).
本发明的组合物可以制备成农药上可接受的剂型，例如水剂、悬浮剂、可溶性液剂、油悬浮剂、微囊剂型、微乳剂、可湿性粉剂等。根据这些组合物的性质以及施用组合物所要达到的目的和环境情况，可以选择将组合物以喷雾、弥雾、喷粉、撒播或泼浇等之类的方法施用。The composition of the present invention can be prepared into a pesticide-acceptable dosage form such as a liquid, a suspension, a soluble liquid, an oil suspension, a microcapsule, a microemulsion, a wettable powder and the like. Depending on the nature of the compositions and the intended purpose and environmental conditions to which the compositions are to be applied, the compositions may be applied by spraying, misting, dusting, spreading or pouring, and the like.
适合本发明的微囊剂型包括：微囊悬浮剂、微囊悬浮-悬浮剂、微囊悬浮-水乳剂等，其特征在于囊壁内(即囊芯)包含由有效成分氯化胆碱和噻苯隆按照一定比例的混合物，即将两者混合制成微型胶囊。将微型胶囊以一定的浓度稳定地分散、悬浮在作为连续相的水中形成微囊悬浮剂。或者将其中一种有效成分制备成微囊悬浮剂，将另外一种有效成分制备成乳液，将制备的两种成分在混合，搅拌，摇匀即得微囊悬浮剂-悬浮剂或微囊悬浮剂-水乳剂。Microcapsule dosage forms suitable for the present invention include: microcapsule suspension, microcapsule suspension-suspension, microcapsule suspension-water emulsion, etc., characterized in that the inner wall of the capsule (ie, the capsule core) contains choline chloride and thiophene as active ingredients. The benzophenone is mixed in a certain proportion, that is, the two are mixed into a microcapsule. The microcapsules are stably dispersed and suspended in a certain concentration to form a microcapsule suspending agent in water as a continuous phase. Alternatively, one of the active ingredients is prepared as a microcapsule suspension, another active ingredient is prepared into an emulsion, and the prepared two components are mixed, stirred, and shaken to obtain a microcapsule suspension-suspension or microcapsule suspension. Agent-water emulsion.
可用已知的方法可以将本发明的组合物制备成各种剂型，可以将有效成分与助剂，如溶剂、固体载体，需要时可以与表面活性剂一起均匀混合、研磨，制备成所需要的剂型。The composition of the present invention can be prepared into various dosage forms by a known method, and the active ingredient and the auxiliary agent, such as a solvent, a solid carrier, and, if necessary, can be uniformly mixed and ground together with the surfactant to prepare a desired preparation. Dosage form.
上述的溶剂可选自芳香烃，优选含8-12个碳原子，如二甲苯混合物或取代的苯，酞酸酯类，如酞酸二丁酯或酞酸二辛酸，脂肪烃类，如环已烷或石蜡，醇和乙二醇和它们的醚和酯，如乙醇，乙二醇，乙二醇单甲基；酮类，如环已酮，强极性的溶剂，如N-甲基-2-吡咯烷酮，二甲基亚砜或二甲基甲酰胺，和植物油或植物油，如大豆油。The above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings. Alkenes or paraffins, alcohols and glycols and their ethers and esters, such as ethanol, ethylene glycol, ethylene glycol monomethyl; ketones, such as cyclohexanone, highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide, and vegetable or vegetable oils such as soybean oil.
上述的固体载体，如用于可湿性粉剂和可分散剂的通常是天然矿物填料，例如滑石、高岭土，蒙脱石或活性白土。为了管理组合物的物理性能，也可以加入高分散性硅酸或高分散性吸附聚合物载体，例如粒状吸附载体或非吸附载体，合适的粒状吸附载体是多孔型的，如浮石、皂土或膨润土；合适的非吸附载体如方解石或砂。另外，可以使用大量的无机性质或有机性质的预制成粒状的材料作为载体，特别是白云石。 The above solid carriers, such as for wettable powders and dispersible agents, are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay. In order to manage the physical properties of the composition, it is also possible to add a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier, such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand. In addition, a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
根据本发明的组合物中的有效成分的化学性质，合适的表面活性剂为木质素磺酸、萘磺酸、苯酚磺酸、碱土金属盐或胺盐，烷基芳基磺酸盐，烷基硫酸盐，烷基磺酸盐，脂肪醇硫酸盐，脂肪酸和硫酸化脂肪醇乙二醇醚，还有磺化萘和萘衍生物与甲醛的缩合物，萘或萘磺酸与苯酚和甲醛的缩合物，聚氧乙烯辛基苯基醚，乙氧基化异辛基酚，辛基酚，壬基酚，烷基芳基聚乙二醇醚，三丁基苯聚乙二醇醚，三硬脂基苯基聚乙二醇醚，烷基芳基聚醚醇，乙氧基化蓖麻油，聚氧乙烯烷基醚，氧化乙烯缩合物、乙氧基化聚氧丙烯，月桂酸聚乙二醇醚缩醛，山梨醇酯，木质素亚硫酸盐废液和甲基纤维素。Suitable surfactants according to the chemical nature of the active ingredient in the composition of the present invention are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene polyglycol ether, three Stearyl phenyl polyglycol ether, alkyl aryl polyether alcohol, ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensate, ethoxylated polyoxypropylene, lauric acid poly Glycol ether acetal, sorbitol ester, lignin sulfite waste liquor and methyl cellulose.
本发明中的植物包括但不限于玉米、麦或水稻等。Plants in the present invention include, but are not limited to, corn, wheat, rice, and the like.
本发明的组合物中两种有效成分表现为增效效果，该组合物的活性比使用单个化合物的活性预期总和，以及单个化合物的单独活性更为显著。本发明的组合物的表现出的其它特点主要表现为：1、本发明的组合物混配具有明显的协同增效作用；2、由于本组合物的两个单剂化学结构差异很大，作用机理完全不同，不存在交互抗性，可延缓两单剂单独使用所产生的抗性问题；3、本发明的组合物可很好的调节作物生长，提高抗病抗逆性，促进作物健康作用，提高作物产量。The two active ingredients in the compositions of the present invention exhibit synergistic effects, the activity of which is more pronounced than the expected sum of activity using a single compound, and the individual activity of a single compound. Other characteristics exhibited by the composition of the present invention are mainly as follows: 1. The composition of the present invention has a significant synergistic effect; 2. Due to the large difference in the chemical structure of the two single agents of the composition, the effect The mechanism is completely different, there is no cross-resistance, which can delay the resistance problem caused by the two single agents alone; 3. The composition of the invention can well regulate crop growth, improve disease resistance and stress resistance, and promote crop health effects. To increase crop yields.
具体实施方式detailed description
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅用以解释本发明，并不用于限定本发明，凡在本发明的精神和原则之内所做的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。In order to make the objects, technical solutions and advantages of the present invention more comprehensible, the present invention will be further described in detail below with reference to the embodiments. It is understood that the specific embodiments described herein are intended to be illustrative of the invention and are not to be construed as limiting the scope of the invention. Within the scope of protection of the present invention.
以下实施例所有配方中百分比均为重量百分比(折百)。本发明组合物各种制剂的加工工艺均为现有技术，根据不同情况可以有所变化。The percentages in all formulations in the following examples are by weight (by hundred percent). The processing techniques of the various formulations of the compositions of the present invention are all prior art and may vary depending on the circumstances.
一、剂型制备实施例First, the dosage form preparation example
(一)悬浮剂的加工及实施例(1) Processing and examples of suspending agents
将活性成分氯化胆碱与噻苯隆，与分散剂、润湿剂、增稠剂和水等各组分按配方的比例混合均匀，经砂磨和/或高速剪切后，得到半成品，分析后补加水混合均匀过滤即得成品。The active ingredients choline chloride and thidiazepine, and the components such as dispersant, wetting agent, thickener and water are uniformly mixed according to the formula, and after sanding and/or high-speed shearing, semi-finished products are obtained. After the analysis, the water is mixed and evenly filtered to obtain the finished product.
实施例1：5.1％噻苯隆·氯化胆碱悬浮剂Example 1: 5.1% thidiazuron choline chloride suspension
噻苯隆5％，氯化胆碱0.1％，苯甲酸钠3％，乙二醇2％，高岭土6％，硅酸铝镁4％，木质素磺酸钠5％,水补足至100％。Thiabendron 5%, choline chloride 0.1%, sodium benzoate 3%, ethylene glycol 2%, kaolin 6%, magnesium aluminum silicate 4%, sodium lignin sulfonate 5%, water to 100%.
实施例2：30.06％噻苯隆·氯代氯化胆碱悬浮剂 Example 2: 30.06% thiabendazole·chlorinated choline chloride suspension
噻苯隆0.06％，氯代氯化胆碱30％，高岭土6％，乙二醇4％，甲基萘磺酸钠甲醛缩合物5％，水补足至100％。Thiabendazole 0.06%, chlorinated choline 30%, kaolin 6%, ethylene glycol 4%, sodium methylnaphthalene sulfonate formaldehyde condensate 5%, water to 100%.
实施例3：2.08％噻苯隆·氯化胆碱悬浮剂Example 3: 2.08% thidiazuron choline chloride suspension
噻苯隆2％，氯化胆碱0.08％，白炭黑5％，丙三醇6％，苯甲酸钠3％，甲基萘磺酸钠甲醛缩合物6％,水补足至100％。Thiabendron 2%, choline chloride 0.08%, white carbon black 5%, glycerol 6%, sodium benzoate 3%, sodium methylnaphthalene sulfonate formaldehyde condensate 6%, water to 100%.
实施例4：22.55％噻苯隆·氯化胆碱悬浮剂Example 4: 22.55% thidiazuron choline chloride suspension
噻苯隆0.05％，氯化胆碱22.5％，白炭黑6％，乙二醇3％，木质素磺酸钠7％,黄原胶2％，水补足至100％。Thiabendron 0.05%, choline chloride 22.5%, white carbon black 6%, ethylene glycol 3%, sodium lignin sulfonate 7%, xanthan gum 2%, water to 100%.
(二)微囊剂的加工及实施例(2) Processing and examples of microcapsules
将有效成分噻苯隆与氯化胆碱按照一定比例的混合物，即将两者混合制成微型胶囊。将微型胶囊以一定的浓度稳定地分散、悬浮在作为连续相的水中形成微囊悬浮剂。或者将其中一种有效成分制备成微囊悬浮剂，将另外一种有效成分制备成乳液，将制备的两种成分在混合，搅拌，摇匀即得微囊悬浮剂-悬浮剂或微囊悬浮剂-水乳剂。The active ingredient thiablon and choline chloride are mixed in a certain ratio, that is, the two are mixed to form a microcapsule. The microcapsules are stably dispersed and suspended in a certain concentration to form a microcapsule suspending agent in water as a continuous phase. Alternatively, one of the active ingredients is prepared as a microcapsule suspension, another active ingredient is prepared into an emulsion, and the prepared two components are mixed, stirred, and shaken to obtain a microcapsule suspension-suspension or microcapsule suspension. Agent-water emulsion.
实施例5：1％噻苯隆·氯代氯化胆碱微囊悬浮剂Example 5: 1% thiabendazole·chlorinated choline microcapsule suspension
噻苯隆0.5％，氯代氯化胆碱0.5％，松脂植物油13％，引诱剂脂肪酸甘油酯4％，乳化剂聚氧乙烯蓖麻油4％，稳定剂亚磷酸三苯酯3.5％，甲苯二异氰酸酯16％，丙烯酸-丙烯酸酯共聚物4％，乙二醇3％，防腐剂苯甲酸钠1％，增稠剂黄原胶2.1％，水补足至100％。Thiabendazole 0.5%, chlorinated choline chloride 0.5%, turpentine vegetable oil 13%, attractant fatty acid glyceride 4%, emulsifier polyoxyethylene castor oil 4%, stabilizer triphenyl phosphate 3.5%, toluene II Isocyanate 16%, acrylic acid-acrylate copolymer 4%, ethylene glycol 3%, preservative sodium benzoate 1%, thickener xanthan gum 2.1%, water to 100%.
实施例6:25.1％噻苯隆·氯化胆碱微囊悬浮剂Example 6: 25.1% thidiazuron choline chloride microcapsule suspension
噻苯隆0.1％，氯化胆碱25％，聚氧乙烯单棕榈酸酯3％，BHT3％、引诱剂氨基酸1％，木质素磺酸盐4％，丙三醇6％，凯松2％，甲酯椰子油15％，乙酸乙烯乳液4％，黄原胶2％，水补足至100％。Thiabendron 0.1%, choline chloride 25%, polyoxyethylene monopalmitate 3%, BHT3%, attractant amino acid 1%, lignosulfonate 4%, glycerol 6%, Kaisong 2% , methyl ester coconut oil 15%, vinyl acetate emulsion 4%, xanthan gum 2%, water to 100%.
实施例7:15.3％噻苯隆·氯化胆碱微囊悬浮剂Example 7: 15.3% thidiazuron choline chloride microcapsule suspension
噻苯隆0.3％，氯化胆碱15％，松脂植物油11％，引诱剂脂肪酸甘油酯4％，聚氧乙烯月桂醚5％，二丙二醇2.5％，稳定剂磷酸二氢钾2％，成囊预聚体甲醛-尿素预聚体18％，卡拉胶0.5％，木质素磺酸钠4％，防腐剂苯甲酸钠1％，水补足至100％。Thiabendazole 0.3%, choline chloride 15%, rosin vegetable oil 11%, attractant fatty acid glyceride 4%, polyoxyethylene lauryl ether 5%, dipropylene glycol 2.5%, stabilizer potassium dihydrogen phosphate 2%, into a capsule Prepolymer formaldehyde-urea prepolymer 18%, carrageenan 0.5%, sodium lignosulfonate 4%, preservative sodium benzoate 1%, water to 100%.
实施例8:30.1％噻苯隆·氯化胆碱囊悬浮-悬浮剂Example 8: 30.1% thiabendazole·choline chloride sac suspension-suspending agent
噻苯隆0.1％，氯化胆碱30％，明胶15％，乙醇3％，三乙胺3％，乙二胺4％，硫酸化脂肪醇乙二醇醚6％，水补足至100％。Thiabendazole 0.1%, choline chloride 30%, gelatin 15%, ethanol 3%, triethylamine 3%, ethylenediamine 4%, sulfated fatty alcohol glycol ether 6%, water to 100%.
实施例9:40.2％噻苯隆·氯化胆碱微囊悬浮剂Example 9: 40.2% thidiazuron choline chloride microcapsule suspension
噻苯隆0.2％，氯化胆碱40％，乳化剂聚氧乙烯蓖麻油8％，引诱剂脂肪酸甘油酯4％，聚氧乙 烯月桂醚5％，乙二醇.5％，稳定剂磷酸二氢钾2％，成囊预聚体甲醛-尿素预聚体18％，卡拉胶0.5％，木质素磺酸钠4％，防腐剂苯甲酸钠1％，水补足至100％。Thiabendazole 0.2%, choline chloride 40%, emulsifier polyoxyethylene castor oil 8%, attractant fatty acid glyceride 4%, polyoxyethylene B Ethyl lauryl ether 5%, ethylene glycol. 5%, stabilizer potassium dihydrogen phosphate 2%, vesicle prepolymer formaldehyde-urea prepolymer 18%, carrageenan 0.5%, sodium lignosulfonate 4%, antiseptic The sodium benzoate is 1% and the water is made up to 100%.
(三)可溶性液剂的加工及实施例(III) Processing and examples of soluble liquid agents
将有效成分噻苯隆与氯化胆碱按照一定比例的混合物、表面活性剂、助剂和水，置于搪瓷釜中，在水浴条件下，充分搅拌直至获得透明液体，即得可溶性液剂。The active ingredient thiablon and choline chloride are placed in an enamel kettle according to a certain ratio of mixture, surfactant, auxiliary agent and water, and stirred under water bath conditions until a transparent liquid is obtained, that is, a soluble liquid agent is obtained.
实施例10:2.2％噻苯隆·氯化胆碱可溶性液剂Example 10: 2.2% thiabendazole·choline chloride soluble solution
噻苯隆0.2％，氯化胆碱2％，烷基苯磺酸钠5％，甲醇12％，乙二醇5％，水补足至100％。Thiabendazole 0.2%, choline chloride 2%, sodium alkylbenzene sulfonate 5%, methanol 12%, ethylene glycol 5%, water to 100%.
实施例11:40.1％噻苯隆·氯化胆碱可溶性液剂Example 11: 40.1% thiabendazole·choline chloride soluble solution
噻苯隆0.1％，氯化胆碱40％，烷基酚聚氧乙烯醚聚氧丙烯醚2％、甲醇2％、乙二醇5％，水补足至100％。Thiabendazole 0.1%, choline chloride 40%, alkylphenol polyoxyethylene ether polyoxypropylene ether 2%, methanol 2%, ethylene glycol 5%, water to 100%.
(四)水剂的加工及实施例(4) Processing and examples of water agents
在反应釜中加入有效成分和助剂，余量用水补足，并搅拌均匀，即可得到噻苯隆·氯化胆碱水剂。The active ingredient and the auxiliary agent are added to the reaction kettle, and the balance is made up with water and stirred uniformly to obtain a thiabendazole-choline chloride aqueous solution.
实施例12:10.4％噻苯隆·氯化胆碱水剂Example 12: 10.4% thiabendazole-choline chloride aqueous solution
将噻苯隆0.4％、二甲基亚砜5％、乙醇5％混匀、搅拌20分钟，再加氯化胆碱10％，搅拌30分钟至氯化胆碱完全溶解；加入8％烷基醇硫酸钠，余量用水补足，搅拌均匀即可得到0.20022％噻苯隆·氯化胆碱水剂。Mix thiazolone 0.4%, dimethyl sulfoxide 5%, ethanol 5%, stir for 20 minutes, add choline chloride 10%, stir for 30 minutes until choline chloride is completely dissolved; add 8% alkyl Sodium sulphate, the balance is made up with water, and evenly stirred to obtain 0.20022% thiabendazole-choline chloride.
实施例13:45.3％噻苯隆·氯化胆碱水剂Example 13: 45.3% thiabendazole-choline chloride aqueous solution
在反应釜中加入噻苯隆原药0.3％和乙醇8％，搅拌20分钟；再加入氯化胆碱45％，搅拌30分钟至乙酰氯化胆碱完全溶解；加入10％脂肪醇聚氧乙烯醚，余量用水补足，搅拌均匀即可得到31.5％噻苯隆·氯化胆碱水剂。Add thiablon original drug 0.3% and ethanol 8% to the reaction kettle, stir for 20 minutes; add choline chloride 45%, stir for 30 minutes until acetylcholine chloride is completely dissolved; add 10% fatty alcohol polyoxyethylene Ether, the balance is made up with water, and evenly stirred to obtain 31.5% of thiabendazole and choline chloride.
实施例14:38％噻苯隆·氯化胆碱水剂Example 14: 38% thiabendazole-choline chloride aqueous solution
在反应釜中加入噻苯隆0.5％和乙醇5％，搅拌20分钟；再加入氯化胆碱37.5％，搅拌30分钟至氯化胆碱完全溶解；加入5％脂肪醇聚氧乙烯醚，余量用水补足，搅拌均匀即可得到0.10125％噻苯隆·氯化胆碱水剂。Add thiabendazole 0.5% and ethanol 5% to the reaction kettle, stir for 20 minutes; add 37.5% choline chloride, stir for 30 minutes until the choline chloride is completely dissolved; add 5% fatty alcohol polyoxyethylene ether, Make up the amount with water and stir evenly to obtain 0.10125% thiabendazole-choline chloride.
实施例15:20.2％噻苯隆·氯化胆碱水剂Example 15: 20.2% thiabendazole-choline chloride aqueous solution
在反应釜中加入噻苯隆0.2％和丙二醇5％，搅拌20分钟；再加入氯化胆碱20％，搅拌30分钟至氯化胆碱完全溶解；加入6％烷基醇硫酸钠，余量用水补足，搅拌均匀即可得到48％噻苯隆·氯化胆碱水剂。Add thiabendazole 0.2% and propylene glycol 5% to the reaction kettle, stir for 20 minutes; add choline chloride 20%, stir for 30 minutes until the choline chloride is completely dissolved; add 6% sodium alkyl sulfate, the balance Make up with water and stir well to get 48% thiabendazole and choline chloride.
实施例16:52.65％噻苯隆·氯化胆碱水剂 Example 16: 52.65% thiabendazole-choline chloride aqueous solution
在反应釜中加入噻苯隆0.15％和丙二醇5％，搅拌20分钟；再加入氯化胆碱52.5％，搅拌30分钟至氯化胆碱完全溶解；加入6％烷基醇硫酸钠，余量用水补足，搅拌均匀即可得到51％噻苯隆·氯化胆碱水剂。Add thiazolone 0.15% and propylene glycol 5% to the reaction kettle, stir for 20 minutes; add 52.5% choline chloride, stir for 30 minutes until choline chloride is completely dissolved; add 6% sodium alkyl sulfate, balance Make up with water and stir well to get 51% thiabendazole and choline chloride.
二、药效验证试验Second, the efficacy test
(一)生物测定实施例(1) Bioassay examples
1、噻苯隆与氯化胆碱复配对玉米生长调节综合测定试验1. Comprehensive determination of corn growth regulation by thiablon and choline chloride
将噻苯隆与氯化胆碱用丙酮按照一定浓度稀释，对作物进行茎叶喷雾，在田间测定各个浓度对作物生长的影响，包括对作物的株高、株径、根长、抗病情况、果实品质，以及产量情况等进行综合评价。The thiabendazole and choline chloride were diluted with acetone at a certain concentration, and the crops were sprayed with stems and leaves. The effects of various concentrations on the growth of the crops were determined in the field, including the plant height, plant diameter, root length and disease resistance of the crops. Comprehensive evaluation of fruit quality, yield, etc.
株高控制率＝(清水对照株高-处理后的株高)/清水对照株高*100％Plant height control rate = (clear water control plant height - treated plant height) / clear water control plant height * 100%
茎径提高率＝(清水对照植株茎径-处理后的植株茎径)/清水对照植株茎径*100％Increasing diameter of stem diameter = (stem diameter of clear water control plant - stem diameter of treated plant) / stem diameter of clear water control plant *100%
预防效果＝(清水对照的发病指数-处理后的发病指数)/清水对照的发病指数*100％Preventive effect = (incidence index of clear water control - incidence index after treatment) / incidence index of clear water control * 100%
籽粒千粒重提高率＝(清水对照的籽粒千粒重-处理后的籽粒千粒重)/清水对照的籽粒千粒重*100％Grain 1000-grain weight increase rate = (1000-grain weight of fresh water control - 1000-grain weight of treated grain) / 1000-grain weight of fresh water control *100%
亩产提高率＝(清水对照的亩产量-处理后的亩产量)/清水对照的亩产量*100％Per mu yield increase rate = (mu yield of clear water control - yield per mu after treatment) / mu yield of clear water control * 100%
表1.噻苯隆与氯化胆碱复配对玉米生长调节综合测定汇总表Table 1. Summary of comprehensive determination of corn growth regulation by thiablon and choline chloride
Figure PCTCN2016094029-appb-000001
Figure PCTCN2016094029-appb-000001
Figure PCTCN2016094029-appb-000002
Figure PCTCN2016094029-appb-000002
注：表格中“噻”为“噻苯隆”的缩写,“氯”为“氯化胆碱”缩写。施药时期：喇叭口初期，该阶段玉米植株未发生开始发生小斑病。施药次数：2次，施药间隔期7天；施药方式：茎叶喷雾；调查时期：玉米抽雄初期；本试验中，株高、茎径、发病指数、籽粒千粒重等指标均为各处理的平均值。Note: In the table, “thio” is the abbreviation of “thiablon” and “chlorine” is the abbreviation of “choline chloride”. Application period: At the beginning of the trumpet, no small spot disease occurred in the corn plants at this stage. The application frequency: 2 times, the application interval is 7 days; the application method: stem and leaf spray; the investigation period: the early stage of corn tasseling; in this experiment, the plant height, stem diameter, disease index, grain 1000-grain weight and other indicators are treated separately. average value.
通过实验发明人发现，噻苯隆与氯化胆碱之间具有很好协同提升作用，噻苯隆与氯化胆碱混配在不同配比下，相对噻苯隆、氯化胆碱单剂，以及清水对照，对玉米的生长调节作用明显，主要表现在：1、本发明可有效增加玉米的株径，提升植株上下营养传导能力，而且通过促进株径，可以提高玉米生长的抗倒伏性能；2、噻苯隆在作为单剂使用时对植物生长具有一定的抗病抗逆作用，而氯化胆碱可以抑制植物内C3光合作用，促进根系的生长发育，对作物病害具有一定免疫力，氯化胆碱与噻苯隆之间共同施用具有良好的协同作用，从上表分析可以看出，噻苯隆与氯化胆碱之间协同作用对玉米小斑病的预防效果相对于单剂及清水对照，具有很好的预防效果；3、本发明可有效调节玉米的控旺徒长，即降低玉米株高和穗位，有效平衡营养生长与生殖生长的关系，防止倒伏；4、由于玉米生长前期噻苯隆与氯化胆碱的协同作用，促进了玉米植株的营养传导、抗病抗逆，在玉米成熟期，对玉米的千粒重以及单位亩产有显著的提升作用，亩产提高率最高达到19.9％；5、噻苯隆与氯化胆碱在配比1：(25-150)之间时，所表现的两者协同增效作用效果明显，当噻苯隆与氯化胆碱的比值低于25或高于150时，两者的协同增效作用效果不明显。Through experiments, the inventors found that there is a good synergistic effect between thiabendone and choline chloride. The mixture of thidiazepine and choline chloride is different in the ratio of thiabendazole and choline chloride. And the clear water control, the growth regulation effect on corn is obvious, mainly in: 1. The invention can effectively increase the plant diameter of the corn, improve the nutrient conduction capacity of the plant, and can improve the lodging resistance of the corn growth by promoting the plant diameter. 2, thiabendone has a certain disease resistance and anti-reverse effect on plant growth when used as a single agent, while choline chloride can inhibit C 3 photosynthesis in plants, promote root growth and development, and have certain immunity to crop diseases. Force, the co-administration between choline chloride and thiabendazole has a good synergistic effect. From the above analysis, it can be seen that the synergistic effect between thiabendazole and choline chloride on the prevention of maize leaf spot is relative to the single The agent and the clear water control have a good preventive effect; 3. The invention can effectively regulate the control of the corn, that is, reduce the plant height and the ear position of the corn, and effectively balance the vegetative growth and the reproductive growth. To prevent lodging; 4, due to the synergistic effect of thiazolone and choline chloride in the early stage of corn growth, promote the nutrient transmission, disease resistance and resistance of maize plants. In the maturity stage of corn, the 1000-grain weight of corn and the yield per mu are significant. The promotion effect of the yield per mu is up to 19.9%; 5, when the ratio of thidiazepine to choline chloride is 1: (25-150), the synergistic effect of the two is obvious. When the ratio of thiabendazole to choline chloride is lower than 25 or higher than 150, the synergistic effect of the two is not obvious.
(二)田间药效验证试验(2) Field efficacy test
1、噻苯隆与氯化胆碱混配对大麦作物调节生长及抗病增产的田间综合试验1. Field comprehensive experiment of regulating growth and disease resistance and increasing yield of barley crops mixed with thiablon and choline chloride
施药时期：大麦灌浆初期，大麦扬花期易发生白粉病等病害。Application period: In the early stage of barley filling, the disease of powdery mildew is prone to occur during the flowering period of barley.
施药次数：1次。利用本发明的制剂实施例进行喷施，三个重复，结果取平均值。 The number of applications: 1 time. Spraying was carried out using the formulation examples of the present invention, three replicates, and the results were averaged.
表2噻苯隆与氯化胆碱混配对大麦调节生长的田间综合实验Table 2 Field comprehensive experiment of barley regulating growth with thiablon and choline chloride
Figure PCTCN2016094029-appb-000003
Figure PCTCN2016094029-appb-000003
从表2实验数据显示，本发明的产品在大麦扬花期施用，可以有效调节大麦的健康生长。主要表现为：1、可以提升大麦的穗长，提高穗粒数；2、可显著提高大麦籽粒的重量；3、噻苯隆对大麦的生长具有一定的促进作用，而氯化胆碱对大麦生长具有一定的抗病抗逆能力，两者混配后具有一定的协同增效作用；4、本发明的组合物对大麦的单位产量具有显著的提升作用。 The experimental data from Table 2 shows that the product of the present invention is applied during the flowering stage of barley, and can effectively regulate the healthy growth of barley. The main performances are as follows: 1. It can increase the ear length of barley and increase the number of grains per spike; 2. It can significantly increase the weight of barley grain; 3. Thiabendazole can promote the growth of barley, while choline chloride can affect barley. Growth has certain resistance to disease and stress, and the two have a synergistic effect after compounding; 4. The composition of the invention has a significant effect on the unit yield of barley.

Claims (10)

  1. 一种植物生长调节剂组合物，其特征在于该组合物包含A和B两种活性组分，其中活性组分A为噻苯隆，活性组分B为氯化胆碱或其衍生物，活性组分A和活性组分B的重量比为1：0.02～500。A plant growth regulator composition, characterized in that the composition comprises two active components A and B, wherein the active component A is thiabendazole and the active component B is choline chloride or a derivative thereof, and the activity The weight ratio of component A to active component B is from 1:0.02 to 500.
  2. 根据权利要求1所述的组合物，其特征在于活性组分A和活性组分B的重量比为1：0.02～480。The composition according to claim 1, wherein the weight ratio of the active component A to the active component B is from 1:0.02 to 480.
  3. 根据权利要求2所述的组合物，其特征在于活性组分A和活性组分B的重量比为1：0.03～450。The composition according to claim 2, wherein the weight ratio of the active component A to the active component B is from 1:0.03 to 450.
  4. 根据权利要求3所述的组合物，其特征在于活性组分A和活性组分B的重量比为1：1～400。The composition according to claim 3, wherein the weight ratio of the active component A to the active component B is from 1:1 to 400.
  5. 根据权利要求1所述的组合物，其特征在于所述氯化胆碱衍生物为氯代氯化胆碱。The composition of claim 1 wherein said choline chloride derivative is choline chloride.
  6. 根据权利要求1所述的组合物，其特征在于该组合物由活性成分和助剂制成农药上允许的剂型。The composition according to claim 1, characterized in that the composition is made into a pesticide-acceptable dosage form from the active ingredient and the adjuvant.
  7. 根据权利要求6所述的组合物，其特征在于所述活性成分在组合物中的质量含量为0.5～80％。The composition according to claim 6, characterized in that the active ingredient is present in the composition in an amount of from 0.5 to 80% by mass.
  8. 根据权利要求6所述的组合物，其特征在于所述剂型为水剂、悬浮剂、可溶液剂或微囊剂型。A composition according to claim 6 wherein the dosage form is a liquid, suspension, solution or microcapsule.
  9. 根据权利要求6所述的组合物，其特征在于所述助剂选自载体、溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂或肥料中的一种或几种。The composition according to claim 6, wherein the auxiliary agent is one selected from the group consisting of a carrier, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder, a surfactant, or a fertilizer, or Several.
  10. 权利要求1～6中任意一项所述的农药组合物在农业领域促进或调节植物生长的用途。 Use of the pesticidal composition according to any one of claims 1 to 6 for promoting or regulating plant growth in the agricultural field.
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