WO2017164202A1 - 光照射装置 - Google Patents
光照射装置 Download PDFInfo
- Publication number
- WO2017164202A1 WO2017164202A1 PCT/JP2017/011326 JP2017011326W WO2017164202A1 WO 2017164202 A1 WO2017164202 A1 WO 2017164202A1 JP 2017011326 W JP2017011326 W JP 2017011326W WO 2017164202 A1 WO2017164202 A1 WO 2017164202A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- blood
- flow path
- light irradiation
- light
- axis direction
- Prior art date
Links
- 210000004369 blood Anatomy 0.000 claims abstract description 113
- 239000008280 blood Substances 0.000 claims abstract description 113
- 241000700605 Viruses Species 0.000 claims abstract description 51
- 239000012503 blood component Substances 0.000 claims abstract description 35
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 42
- 239000010836 blood and blood product Substances 0.000 description 24
- 229940125691 blood product Drugs 0.000 description 24
- 239000007788 liquid Substances 0.000 description 16
- 238000012545 processing Methods 0.000 description 16
- 230000023555 blood coagulation Effects 0.000 description 13
- 210000003743 erythrocyte Anatomy 0.000 description 11
- 230000000415 inactivating effect Effects 0.000 description 8
- 230000002779 inactivation Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 230000001678 irradiating effect Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000017525 heat dissipation Effects 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000003761 preservation solution Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0047—Ultraviolet radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
- A61M2205/053—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy ultraviolet
Definitions
- the present invention relates to a light irradiation apparatus for irradiating light to blood or blood components in order to inactivate viruses contained in blood or blood components.
- Patent Document 1 discloses a light irradiation device for irradiating light to a blood bag containing blood.
- the light irradiation device disclosed in Patent Document 1 inactivates the virus while stirring the blood in the blood bag and passing it through the thin layer portion, but the virus in the blood bag is sufficiently stirred to It takes a lot of time to inactivate. For this reason, the time required to inactivate the virus contained in the blood in the blood bag becomes long. In addition, blood coagulation may occur due to this.
- the present invention has been made to solve the above-described problems, and it is an object of the present invention to provide a light irradiation apparatus that is less likely to cause blood coagulation and can inactivate viruses contained in blood or blood components in a short time.
- One aspect of the present invention made to solve the above-described problems is that, in the light irradiation device, the flow path for flowing blood or blood components, and the flow for inactivating the viruses contained in the blood or blood components.
- An LED lamp that irradiates light to the blood or blood components flowing through the path, and a multilayer structure in which a plurality of the flow paths are arranged in parallel is formed.
- the total volume of the flow paths can be increased by forming a multilayer structure in which a plurality of flow paths are arranged in parallel.
- the amount of blood or blood components processed per unit time can be increased, so that the processing ability to inactivate viruses contained in blood or blood components is improved.
- blood or blood components are irradiated with light while flowing blood or blood components in the flow path, blood coagulation hardly occurs. Therefore, blood coagulation hardly occurs and viruses contained in blood or blood components can be inactivated in a short time.
- the multilayer structure is formed in each of the first direction orthogonal to the axial direction of the flow path and the second direction orthogonal to the axial direction of the flow path and the first direction. It is preferable.
- the processing amount of blood or blood components per unit time can be further increased. For this reason, the processing ability to inactivate viruses contained in blood or blood components is further improved, so that viruses contained in blood or blood components can be inactivated in a shorter time.
- the LED lamps are disposed at positions on both sides of the flow path in a direction orthogonal to the axial direction of the flow path.
- a cross section perpendicular to the axial direction of the flow channel in the flow channel is formed in a flat shape, and the LED lamp is disposed at a position on the short side of the flat shape with respect to the flow channel. It is preferable that
- a plurality of the LED lamps are arranged in the axial direction of the flow path.
- the flow path is formed in a linear shape in the axial direction of the flow path.
- the blood or blood component flowing through the flow path is unlikely to be subjected to flow path resistance, so that the amount of blood or blood component processed per unit time can be increased.
- the flow path is formed in a curved shape in the axial direction of the flow path.
- the volume of the flow path can be secured in a limited space, the amount of blood or blood components processed per unit time can be increased.
- the light is preferably ultraviolet light.
- the virus since the virus can be effectively inactivated by ultraviolet light, the processing ability to inactivate the virus contained in blood or blood components is improved.
- the light irradiation apparatus of the present invention blood coagulation hardly occurs, and viruses contained in blood or blood components can be inactivated in a short time.
- UV irradiation unit of this embodiment It is a block diagram of the UV irradiation unit of this embodiment. It is a figure which shows the YZ cross section in the peripheral part of a flow path and an ultraviolet LED lamp. It is an exploded view of the UV irradiation unit of this embodiment. It is a block diagram when the virus contained in a blood product is inactivated using the UV irradiation unit of this embodiment. It is a figure which shows the flow path of a modification.
- the UV irradiation unit 1 which is an example of the light irradiation apparatus of the present invention will be described.
- the UV irradiation unit 1 includes a circuit unit 11, an irradiation unit 12, a liquid feed pump 13, a control unit 14, and the like.
- XYZ axes orthogonal to each other are assumed as shown in FIG.
- the X-axis direction is a direction (left-right direction in FIG. 1) parallel to the axial direction (axial direction, central axis direction) of the second portion 32 b (flow path 41) of the branch tube 32. This corresponds to the flow direction of blood or blood components flowing through the flow path 41 in the second portion 32b.
- the circuit unit 11 includes a plurality of tubes 21 and an attachment auxiliary unit 22.
- the tube 21 includes a flow path 41 for flowing blood or blood components.
- the flow path 41 corresponds to the lumen of the tube 21.
- blood or blood components are whole blood, concentrated red blood cells, platelets or plasma, and hereinafter simply referred to as “blood”.
- the tube 21 is disposable and is formed of a transparent resin that does not contain a UV absorber. Thereby, more UV light (ultraviolet light) irradiated from the ultraviolet LED lamp 52 can be applied to the blood flowing through the flow path 41.
- the circuit unit 11 includes, as the plurality of tubes 21, one inlet side tube 31, a plurality of branch tubes 32, and one outlet side tube 33.
- a plurality of branch tubes 32 are connected to the inlet side tube 31 and the outlet side tube 33. That is, in the circuit unit 11, a plurality of branch tubes 32 branched from one inlet side tube 31 are connected to one outlet side tube 33. In this way, the plurality of tubes 21 are integrated in the circuit unit 11.
- the branch tube 32 includes a first part 32a whose axial direction (blood flow direction) is formed along the Z-axis direction and a second part 32b whose axial direction is formed along the X-axis direction. I have.
- a plurality of branch tubes 32 are arranged in parallel. Specifically, the Y-axis direction (first direction orthogonal to the axial direction of the flow path 41 (blood flow direction)) and the Z-axis direction (second direction orthogonal to the axial direction of the flow path 41 and the first direction). ), The second portions 32b of the plurality of branch tubes 32 are arranged in parallel. Thereby, in the UV irradiation unit 1, a multilayer structure is formed in which a plurality of flow paths 41 are arranged in parallel in the Y-axis direction and the Z-axis direction, respectively.
- the flow path cross section (YZ cross section (cross section formed in the Y axis direction and the Z axis direction)) perpendicular to the axial direction of the flow path 41 in the flow path 41 is formed in a flat shape.
- the channel cross section of the channel 41 is formed in a flat shape in which the Y-axis direction is the longitudinal direction and the Z-axis direction is the short direction.
- the outer shape of the channel cross section of the channel 41 is formed in, for example, an oval shape (a shape having a pair of opposing linear portions and a pair of arc portions connecting both ends of the linear portion). ing.
- the second portion 32b of the branch tube 32 is formed in a linear shape along the X-axis direction as shown in FIG.
- the flow path 41 (hereinafter simply referred to as “flow path 41 of the branch tube 32”) in the second portion 32b of the branch tube 32 is formed in a linear shape in the axial direction (X-axis direction). Yes.
- the attachment assisting part 22 holds the second portions 32b of the plurality of branch tubes 32 in the holding part 22a. In this way, the attachment assisting part 22 holds a plurality of integrated tubes 21. Further, the attachment assisting portion 22 includes a handle 23. Therefore, the operator can detach the circuit unit 11 from the irradiation unit 12 while holding the handle 23. As described above, the attachment assisting portion 22 functions as an assist for facilitating attachment of the circuit portion 11 to the irradiation portion 12.
- the irradiation unit 12 includes an LED arrangement unit 51, an ultraviolet LED lamp 52, and a groove 53.
- a plurality of LED arrangement portions 51 are formed.
- the plurality of LED arrangement portions 51 for example, as shown in FIG. 3, five LED arrangement portions 51 including a first LED arrangement portion 51A to a fifth LED arrangement portion 51E are formed.
- the first LED arrangement portion 51A, the second LED arrangement portion 51B, the third LED arrangement portion 51C, the fourth LED arrangement portion 51D, and the fifth LED arrangement portion 51E are formed in this order.
- a plurality of ultraviolet LED lamps 52 are provided.
- a plurality of ultraviolet LED lamps 52 are arranged in the X-axis direction and the Y-axis direction in the first LED arrangement unit 51A to the fifth LED arrangement unit 51E. And in the 1st LED arrangement
- the ultraviolet LED lamps 52 are arranged in two rows in the Z-axis direction.
- the ultraviolet LED lamp 52 irradiates the blood flowing through the flow path 41 of the branch tube 32 with UV light in order to inactivate viruses contained in the blood.
- the UV light emitted from the ultraviolet LED lamp 52 may be any of UV-A, UV-B, and UV-C, but UV-A and UV-B that are not easily reflected or absorbed by red blood cells are particularly desirable. .
- a plurality of groove portions 53 are formed, and are formed between adjacent LED arrangement portions 51. Thereby, a space is formed between adjacent LED placement portions 51. And the holding
- the groove 53A is between the first LED arrangement part 51A and the second LED arrangement part 51B
- the groove part 53B is between the second LED arrangement part 51B and the third LED arrangement part 51C
- the groove part 53C is the third LED arrangement part 51C and the fourth LED arrangement.
- the groove part 53D is formed between the fourth LED arrangement part 51D and the fifth LED arrangement part 51E.
- the ultraviolet LED lamp 52 is arrange
- the ultraviolet LED lamps 52 arranged in two rows in the Z-axis direction are arranged in directions in which the irradiation directions of the UV light are the first groove portion 53A direction and the second groove portion 53B direction, respectively.
- the ultraviolet LED lamps 52 arranged in two rows in the Z-axis direction are arranged in directions in which the irradiation directions of the UV light are the second groove portion 53B direction and the third groove portion 53C direction, respectively. ing.
- the ultraviolet LED lamps 52 arranged in two rows in the Z-axis direction are arranged in directions in which the irradiation directions of the UV light are the third groove portion 53C direction and the fourth groove portion 53D direction, respectively.
- the ultraviolet LED lamp 52 is arranged in an orientation in which the irradiation direction of the UV light is in the direction of the fourth groove portion 53D.
- the ultraviolet LED lamp 52 is in the Z-axis direction with respect to the flow path 41 of the branch tube 32 as shown in FIG. It is arranged at the position of both sides. Further, a plurality of ultraviolet LED lamps 52 are arranged along the axial direction (X-axis direction) of the flow path 41 of the branch tube 32.
- two flow paths 41 of the branch tube 32 are arranged in parallel in the Y axis direction and four in the Z axis direction.
- the number of the flow paths 41 arranged in parallel is not particularly limited.
- two or more flow paths 41 of the branch tube 32 are arranged in parallel in the Y-axis direction and the Z-axis direction, or only one channel is arranged in the Y-axis direction and two or more channels are arranged in the Z-axis direction. Two or more may be juxtaposed in the direction and only one may be arranged in the Z-axis direction.
- the UV irradiation unit 1 includes a first liquid feed pump 13A and a second liquid feed pump 13B as the liquid feed pump 13.
- the first liquid feed pump 13 ⁇ / b> A is connected to the inlet side tube 31.
- the second liquid feed pump 13 ⁇ / b> B is connected to the outlet side tube 33.
- the control unit 14 is configured by, for example, a microcomputer, and controls the operation of each component of the UV irradiation unit 1 such as driving of the liquid feeding pump 13 and irradiation of the ultraviolet LED lamp 52.
- the pre-inactivation blood product bag 61 storing the blood product before inactivating the virus and the diluted solution (preservation solution) are stored in the inlet side tube 31 of the UV irradiation unit 1.
- the diluted solution bag 62 is connected.
- the tube 71 is connected to the inlet side tube 31 of the UV irradiation unit 1 via the first liquid feeding pump 13A.
- a tube 72 connected to the pre-inactivation blood product bag 61 and a tube 73 connected to the diluted solution bag 62 are connected to the tube 71.
- an inactivated blood product bag 63 for storing the blood product after inactivating the virus is connected to the outlet side tube 33 of the UV irradiation unit 1.
- the tube 81 connected to the post-inactivation blood product bag 63 is connected to the outlet side tube 33 of the UV irradiation unit 1 via the second liquid feeding pump 13B.
- control unit 14 drives the first liquid pump 13A and the second liquid pump 13B to transfer the blood product from the pre-inactivated blood product bag 61 to the circuit unit 11 through the tube 72 and the tube 71. Shed. At this time, the blood product is diluted with the diluted solution flowing from the diluted solution bag 62 to the circuit unit 11 through the tube 73 and the tube 71.
- control unit 14 irradiates the blood product flowing through the flow path 41 of the branch tube 32 with UV light by the ultraviolet LED lamp 52. In this way, the virus contained in the blood product is inactivated. Then, the blood product after inactivating the virus is stored in the blood product bag 63 after inactivation. In addition, since the blood product is diluted with a diluting solution and has a reduced concentration, it becomes difficult for UV light to be absorbed or reflected by red blood cells, and the processing ability to inactivate viruses is improved. The above is the description of the operation of the UV irradiation unit 1.
- the plurality of flow paths 41 are arranged in parallel as described above. Specifically, the flow paths 41 of the plurality of branch tubes 32 are arranged in parallel in the Y-axis direction and the Z-axis direction, respectively. Thus, in the UV irradiation unit 1, a multilayer structure is formed in which the plurality of flow paths 41 are arranged in parallel in the Y-axis direction and the Z-axis direction, respectively.
- the ultraviolet LED lamp 52 that does not easily generate heat is used as a light source for irradiating UV light, it is possible to easily take measures against heat dissipation.
- the LED lamp 52 and the branch tube 32 can be brought close to each other to make them multilayer. Therefore, by arranging a plurality of branch tubes 32 in parallel and forming a multilayer structure in which the plurality of channels 41 are arranged in parallel, the volume of the channels 41 in the circuit unit 11 can be increased. Therefore, the amount of blood processed per unit time in the entire UV irradiation unit 1 can be increased.
- the ultraviolet LED lamps 52 are unlikely to generate heat, it is possible to easily take measures against heat dissipation, and therefore, the ultraviolet LED lamps 52 can be brought close to each other. Therefore, in the UV irradiation unit 1 of the present embodiment, as illustrated in FIG. 2, the ultraviolet LED lamps 52 are disposed at positions on both sides in the Z-axis direction with respect to the flow path 41 of the branch tube 32. Thus, in the UV irradiation unit 1, a double-sided irradiation structure that irradiates the blood flowing through the flow channel 41 with UV light from both surfaces of the flow channel 41 is formed. Therefore, it is possible to increase the irradiation amount of UV light to blood.
- UV light emitted from the ultraviolet LED lamp 52 disposed at one position with respect to the flow path 41 strikes and absorbs or reflects red blood cells in the blood, the position on the other side with respect to the flow path 41.
- the UV light emitted from the ultraviolet LED lamp 52 disposed on the blood can pass through the blood without hitting the red blood cells in the blood. Therefore, it becomes easy for UV light to penetrate into blood.
- An irradiation structure is formed. Therefore, in the UV irradiation unit 1, the amount of UV light applied to the blood can be increased while increasing the amount of blood processed per unit time, and the UV light is easily transmitted into the blood. Therefore, according to the UV irradiation unit 1, the processing ability to inactivate the virus contained in the blood is improved, so that the virus contained in the blood can be inactivated in a short time.
- the virus contained in the blood is inactivated by irradiating the blood with UV light while flowing the blood from the upstream side to the downstream side in the flow path 41. Activate. Therefore, in the UV irradiation unit 1, blood stays less easily than in the case of irradiating UV light to blood stored in a blood bag as in the conventional case (in the case of batch-type virus inactivation treatment). Blood clotting is unlikely to occur.
- the UV irradiation unit 1 has a multi-layer structure in which a plurality of flow paths 41 are arranged in parallel in the Y-axis direction and the Z-axis direction, and the volume of the flow paths 41 is secured.
- the length of 32 that is, the length of the flow path 41 of the branch tube 32 in the X-axis direction can be made as short as possible. Therefore, the distance for flowing the blood to the flow path 41 can be shortened as much as possible, and the time for flowing the blood to the flow path 41 can be shortened as much as possible, so that blood coagulation hardly occurs. Therefore, according to the UV irradiation unit 1, blood coagulation hardly occurs, and the virus contained in the blood can be inactivated in a short time.
- the UV irradiation unit 1 of the present embodiment instead of increasing the flow area of the flow path 41 (area in the flow path cross section) to ensure the volume of the flow path 41 in the circuit unit 11, The volume of the flow path 41 in the circuit unit 11 is ensured by arranging a plurality of flow paths 41 having a small flow area in parallel.
- the flow channel area of the flow channel 41 is increased, there is a possibility that a portion where blood stays in the flow channel 41 and blood coagulation occurs.
- the UV irradiation unit 1 of the present embodiment since the flow channel area of the flow channel 41 can be reduced, a portion where blood stays in the flow channel 41 hardly occurs and blood coagulation hardly occurs.
- the flow rate of blood flowing through the flow path 41 can be controlled by the liquid feeding pump 13, and therefore the blood flow rate is controlled so that the virus can be inactivated efficiently. Can do. Further, the flow rate of blood flowing through the flow path 41 can be controlled by the liquid feed pump 13 to a flow rate at which blood coagulation hardly occurs in the flow path 41.
- the UV irradiation unit 1 of the present embodiment when the blood product of whole blood or concentrated red blood cells is flowed to the flow path 41, the red blood cells flow while flowing in the flow path 41.
- the irradiated UV light is less likely to be absorbed or reflected by red blood cells. Therefore, even when red blood cells are contained, such as blood products of whole blood or concentrated red blood cells, UV light easily passes through the blood products, so that viruses contained in the blood products are easily inactivated. Become.
- the cross section of the flow path in the flow path 41 is formed in a flat shape, and the ultraviolet LED lamp 52 is disposed at a position on the short side (Z-axis direction) side of the flat shape with respect to the flow path 41.
- the UV light can be irradiated from the ultraviolet LED lamp 52 to the surface of the flow channel 41 formed along the longitudinal direction of the cross section of the flow channel. Therefore, it is possible to increase the amount of UV light applied to the blood flowing through the flow path 41.
- the UV light easily penetrates into the blood flowing through the flow path 41.
- the UV irradiation unit 1 of the present embodiment a plurality of ultraviolet LED lamps 52 are arranged in the axial direction (X-axis direction) of the flow path 41 of the branch tube 32.
- the UV irradiation unit 1 is formed so as to continuously irradiate the blood flowing through the flow path 41 along the flow direction. Therefore, it is possible to further increase the amount of UV light irradiated on the blood.
- the ultraviolet LED lamp 52 is less likely to generate heat than a conventional UV lamp such as a mercury UV lamp, it is sufficient to simply take measures for heat radiation. Therefore, the ultraviolet LED lamp 52 can be in close contact with the branch tube 32 as compared with the conventional UV lamp. Therefore, since the groove part 53 in the irradiation part 12 can be made as small as possible, the flow path 41 can be multilayered in a limited space. Therefore, the UV irradiation unit 1 can be reduced in size.
- the life of the ultraviolet LED lamp 52 is remarkably longer than that of the conventional UV lamp. Further, the UV LED lamp 52 is less likely to cause a decrease in illuminance. Therefore, it is difficult for variations in the performance of the treatment for inactivating viruses contained in blood.
- a photoactive virus inactivating agent such as riboflavin
- the virus contained in blood can be inactivated efficiently.
- the illuminance of the UV light of the ultraviolet LED lamp 52 is set to 30 W, and six channels 41 of the branch tube 32 are arranged in the Y-axis direction and five stages in the Z-axis direction.
- the length of the flow path 41 of the branch tube 32 in the axial direction (X-axis direction) is 300 mm.
- the flow path 41 of the branch tube 32 may be formed in a curved shape in the axial direction.
- the flow path 41 of the branch tube 32 has its axis curved from the X-axis direction to the Y-axis direction and from the Y-axis direction to the X-axis direction. Is formed. Thereby, the volume of the flow path 41 is securable.
- a multilayer structure is formed in which a plurality of flow paths 41 are arranged in parallel in the Z-axis direction, and the ultraviolet LED lamp 52 is positioned on both sides of the flow path 41 in the Z-axis direction. Has been placed. A plurality of ultraviolet LED lamps 52 are arranged in the axial direction of the flow path 41.
- the UV irradiation unit 1 of the present embodiment includes the flow channel 41 that flows blood and the ultraviolet LED that irradiates the blood flowing through the flow channel 41 with UV light in order to inactivate viruses contained in the blood. And a multi-layer structure in which a plurality of flow paths 41 are arranged in parallel.
- the total volume of the flow path 41 in the circuit unit 11 can be increased by forming a multilayer structure in which the plurality of flow paths 41 are arranged in parallel. Therefore, since the amount of blood processed per unit time can be increased, the processing ability to inactivate viruses contained in blood is improved. Moreover, since the virus can be effectively inactivated by UV light, the processing ability to inactivate the virus contained in blood is improved. Moreover, since UV light is irradiated to the blood while flowing the blood in the flow path 41, the blood is less likely to stay, and thus blood coagulation is difficult to occur. Therefore, according to the UV irradiation unit 1 of the present embodiment, blood coagulation hardly occurs and viruses contained in blood can be inactivated in a short time.
- the UV irradiation unit 1 of the present embodiment has a multilayer structure in which a plurality of flow paths 41 are arranged in parallel in the Y-axis direction and the Z-axis direction, respectively.
- the amount of blood processed per unit time can be further increased. Therefore, since the processing ability to inactivate viruses contained in blood is further improved, viruses contained in blood can be inactivated in a shorter time.
- the ultraviolet LED lamps 52 are arranged on both sides with respect to the flow path 41 in the Z-axis direction. Thereby, the irradiation amount of the UV light with respect to the blood which flows through the flow path 41 can be increased. In addition, the UV light easily penetrates into the blood flowing through the flow path 41. Therefore, the processing ability to inactivate viruses contained in blood is improved.
- the cross section of the flow path 41 is formed in a flat shape, and the ultraviolet LED lamp 52 is flat with respect to the flow path 41 in the short direction (Z-axis direction). It is arranged at the side position. Thereby, the irradiation amount of the UV light with respect to the blood which flows through the flow path 41 can be increased. In addition, the UV light easily penetrates into the blood flowing through the flow path 41. Therefore, the processing ability to inactivate viruses contained in blood is improved.
- a plurality of ultraviolet LED lamps 52 are arranged in the axial direction of the flow path 41. Thereby, the irradiation amount of the UV light with respect to the blood which flows through the flow path 41 can be increased. Therefore, the processing ability to inactivate viruses contained in blood is improved.
- the flow path 41 of the branch tube 32 is formed in a linear shape in the axial direction. Therefore, since the blood flowing through the flow path 41 is not easily subjected to flow path resistance, the amount of blood processed per unit time can be increased.
- the flow path 41 of the branch tube 32 may be formed in a curved shape in the axial direction. Thereby, since the volume of the flow path 41 can be ensured in a limited space, the amount of blood processed per unit time can be increased.
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Abstract
Description
また、それに起因して血液凝固が起こるおそれがある。
11 回路部
12 照射部
13 送液ポンプ
13A 第1送液ポンプ
13B 第2送液ポンプ
14 制御部
21 チューブ
23 持ち手
31 入口側チューブ
32 分岐チューブ
32b 第2部位
33 出口側チューブ
41 流路
52 紫外線LEDランプ
61 不活化前血液製剤バッグ
63 不活化後血液製剤バッグ
Claims (8)
- 血液または血液成分を流す流路と、
前記血液または前記血液成分に含まれるウイルスを不活化するために、前記流路を流れる前記血液または前記血液成分に対して光を照射するLEDランプと、を有し、
複数の前記流路が並列に配置される多層構造が形成されていること、
を特徴とする光照射装置。 - 請求項1の光照射装置において、
前記流路の軸方向と直交する第1方向、および、前記流路の軸方向と前記第1方向とに直交する第2方向について、各々、前記多層構造が形成されていること、
を特徴とする光照射装置。 - 請求項1または2の光照射装置において、
前記LEDランプは、前記流路の軸方向と直交する方向について前記流路に対して両側の位置に配置されていること、
を特徴とする光照射装置。 - 請求項1乃至3のいずれか1つの光照射装置において、
前記流路における当該流路の軸方向に垂直な断面が偏平形状に形成され、
前記LEDランプは、前記流路に対して前記偏平形状の短手方向側の位置に配置されていること、
を特徴とする光照射装置。 - 請求項1乃至4のいずれか1つの光照射装置において、
前記LEDランプは、前記流路の軸方向について複数配置されていること、
を特徴とする光照射装置。 - 請求項1乃至5のいずれか1つの光照射装置において、
前記流路は、当該流路の軸方向について、直線形状に形成されていること、
を特徴とする光照射装置。 - 請求項1乃至5のいずれか1つの光照射装置において、
前記流路は、当該流路の軸方向について、湾曲形状に形成されていること、
を特徴とする光照射装置。 - 請求項1乃至7のいずれか1つの光照射装置において、
前記光は、紫外光であること、
を特徴とする光照射装置。
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EP17770244.6A EP3434295B1 (en) | 2016-03-23 | 2017-03-22 | Light irradiation device |
CN201780019460.0A CN108778357B (zh) | 2016-03-23 | 2017-03-22 | 光照射装置 |
US16/086,989 US20190099543A1 (en) | 2016-03-23 | 2017-03-22 | Light irradiation device |
JP2018507353A JP6895426B2 (ja) | 2016-03-23 | 2017-03-22 | 光照射装置 |
US17/347,826 US20210308360A1 (en) | 2016-03-23 | 2021-06-15 | Light irradiation device |
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US16/086,989 A-371-Of-International US20190099543A1 (en) | 2016-03-23 | 2017-03-22 | Light irradiation device |
US17/347,826 Continuation US20210308360A1 (en) | 2016-03-23 | 2021-06-15 | Light irradiation device |
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EP (1) | EP3434295B1 (ja) |
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Cited By (3)
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KR20200020525A (ko) * | 2018-08-17 | 2020-02-26 | 서울시립대학교 산학협력단 | Dna 디메틸화를 위한 테라헤르츠파 조사 장치 및 이를 포함하는 dna 디메틸화 시스템 |
JP2021176469A (ja) * | 2020-05-08 | 2021-11-11 | 誠一 田中 | 紫外線利用血中ウィルス不活性化装置 |
WO2022079827A1 (ja) | 2020-10-14 | 2022-04-21 | 大塚電子株式会社 | 血液のための冷却水循環部を備える光線力学的療法装置 |
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IL275698B1 (en) | 2017-12-29 | 2024-04-01 | Cerus Corp | Systems and methods for treating biological fluids |
WO2020023942A2 (en) | 2018-07-27 | 2020-01-30 | Terumo Bct Biotechnologies, Llc | Fluid flow-through |
JP2022539154A (ja) | 2019-06-28 | 2022-09-07 | シーラス コーポレイション | 生物学的流体処理デバイスを実装するためのシステム及び方法 |
CN110721359A (zh) * | 2019-10-24 | 2020-01-24 | 成都市佳颖医用制品有限公司 | 血液自动化治疗采集系统及使用方法 |
CN111544296B (zh) * | 2020-06-18 | 2024-03-12 | 四川省人民医院 | 一种血液制品光能保藏袋 |
US20240024557A1 (en) * | 2022-07-25 | 2024-01-25 | William M. Gosney | Cassette apparatus for processing of blood to neutralize pathogen cells therein |
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- 2017-03-22 WO PCT/JP2017/011326 patent/WO2017164202A1/ja active Application Filing
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Publication number | Publication date |
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EP3434295A1 (en) | 2019-01-30 |
EP3434295A4 (en) | 2019-11-13 |
JPWO2017164202A1 (ja) | 2019-02-07 |
US20210308360A1 (en) | 2021-10-07 |
EP3434295B1 (en) | 2022-03-09 |
CN108778357B (zh) | 2021-12-03 |
JP6895426B2 (ja) | 2021-06-30 |
US20190099543A1 (en) | 2019-04-04 |
CN108778357A (zh) | 2018-11-09 |
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