WO2017149819A1 - Composition pour augmenter le rendement de transmission ultrasonore, composition de gel pour diagnostic par ultrasons et procédé de diagnostic par ultrasons - Google Patents

Composition pour augmenter le rendement de transmission ultrasonore, composition de gel pour diagnostic par ultrasons et procédé de diagnostic par ultrasons Download PDF

Info

Publication number
WO2017149819A1
WO2017149819A1 PCT/JP2016/079246 JP2016079246W WO2017149819A1 WO 2017149819 A1 WO2017149819 A1 WO 2017149819A1 JP 2016079246 W JP2016079246 W JP 2016079246W WO 2017149819 A1 WO2017149819 A1 WO 2017149819A1
Authority
WO
WIPO (PCT)
Prior art keywords
ultrasonic
composition
transmission efficiency
ultrasonic transmission
vesicle
Prior art date
Application number
PCT/JP2016/079246
Other languages
English (en)
Japanese (ja)
Inventor
野畑　靖浩
梨絵 氏原
酒井　亮一
尾形　太
Original Assignee
伯東株式会社
株式会社日立製作所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 伯東株式会社, 株式会社日立製作所 filed Critical 伯東株式会社
Priority to CN201680083158.7A priority Critical patent/CN109069129B/zh
Publication of WO2017149819A1 publication Critical patent/WO2017149819A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/13—Tomography
    • A61B8/14—Echo-tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo

Definitions

  • the present invention relates to an ultrasonic transmission efficiency improving composition containing a component for improving ultrasonic transmission efficiency at the time of ultrasonic diagnosis, and a superposition which is a coating-type contact medium in which the ultrasonic transmission efficiency improving composition is gelled.
  • the present invention relates to an ultrasonic diagnostic gel composition, the ultrasonic transmission efficiency improving composition, and an ultrasonic diagnostic method using the ultrasonic diagnostic gel composition.
  • Ultrasound diagnosis is a non-invasive diagnosis and is often used in health checkups.
  • a coated contact for ultrasound diagnostics as an acoustic matching medium between those surfaces Media is introduced. It is usually an aqueous material (liquid substance) such as a gel or gel, that is, a liquid having a relatively high viscosity.
  • the application-type contact medium is first applied to the skin, The probe is pressed against the applied skin to transmit ultrasonic waves, and diagnosis is performed by reflection of the subcutaneous tissue.
  • Patent Document 1 discloses an alkyl-modified carboxyvinyl polymer and / or a salt thereof, a carboxyvinyl polymer and / or a salt thereof as an application-type contact medium for ultrasonic diagnosis capable of efficiently transmitting ultrasonic waves to the skin,
  • a gel composition containing hydroxyalkyl cellulose, polyacrylic acid and / or a salt thereof, and a polyhydric alcohol is disclosed.
  • Polyhydric alcohols are 1,3-butylene glycol, 1,2-pentanediol, 1,3-pentanediol, glycerin, sorbitol, mannitol, diglycerin, polyglycerin, ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, Propylene glycol, pentaerythritol, etc. alone or two or more of 10.0 to 50.0% by weight are appropriate.
  • Patent Document 2 discloses a coating type contact medium for ultrasonic diagnosis which is made of a gel containing curdlan as a main component and at least a part of the gel is chemically crosslinked. It is also disclosed that the coating-type contact medium for ultrasonic diagnosis has appropriate flexibility, mechanical strength, and good acoustic characteristics (such as a low ultrasonic attenuation rate).
  • Patent Document 3 discloses a (meth) acrylic acid polymer or a salt thereof, a (meth) acrylic acid / (meth) acrylic ester copolymer or a salt thereof, and a polyhydric alcohol having 3 to 6 hydroxyl groups in the molecule.
  • This coating-type contact medium for ultrasonic diagnosis contains a practical viscosity that does not flow on the surface of a living body, and the ultrasonic image is well reflected, easily squeezed from a container, easy to stretch, non-sticky, and salt-resistant. It is disclosed that it is excellent in properties and does not solidify after drying.
  • Patent Document 4 contains a salt of carboxyvinyl polymer, xanthan gum and polyhydric alcohol, and when polyhydric alcohol is added at a high concentration, this effect becomes more remarkable, and the conventional problems are greatly improved.
  • a coating-type contact medium for ultrasonic diagnosis that is suitable for an elderly person who cannot obtain a clear image is disclosed.
  • Patent Document 5 discloses that an alginate is contained in a solid matrix polymer of a polymerizable vinyl monomer, so that ultrasonic conduction efficiency is high and does not affect an image (specifically, acoustic impedance is not applied to a living body). Nearly, ultrasonic attenuation is small), hard to dry, smooth solid, high stability against sweat and temperature, no skin allergies, high stability, no odor A contact medium for ultrasonic diagnostics is disclosed.
  • ethylene glycol is used as an ultrasonic transmission medium in order to prevent a decrease in sensitivity due to reflection of an echo signal resulting from a difference in acoustic impedance between an ultrasonic probe and a coating-type contact medium for ultrasonic diagnosis.
  • a technique for improving the transmission sensitivity of ultrasonic waves using 5-pentanediol is disclosed.
  • Patent Document 7 includes an emollient component that imparts flexibility and moisture to the skin of an application-type contact medium for ultrasonic diagnosis, thereby improving ultrasonic transmission and smoothing the sliding between the skin and the device. In addition, it is disclosed that there is little stickiness after use, it is excellent in actual safety and safety image with respect to the skin, and has an appropriate cosmetic effect.
  • the stratum corneum of the skin is composed of stratum corneum cells and intercellular lipids.
  • the intercellular lipid has a lipid lamellar structure and is moistened with moisture.
  • people who have rough skin are in a state where the lamellar structure is disturbed and moisture easily evaporates.
  • the elderly have a stratum corneum deposition phenomenon in which the exfoliation enzyme does not work due to aging and the stratum corneum accumulates. As a result, the barrier function is increased and moisture does not reach from the lower part of the skin and is dried.
  • the dry skin constitution has a phenomenon that the NMF component is not sufficient, and the stratum corneum has insufficient flexibility and water content.
  • the moisture content of the stratum corneum is small, it is refracted at the interface of paths with different velocities, reflected between media with large acoustic impedance differences, or ultrasonic waves at boundaries with sufficiently small acoustic impedance differences.
  • the sensitivity is lowered due to scattering when incident.
  • the present invention has been made in view of the above-described conventional situation, and in particular, an ultrasonic transmission efficiency improving composition for improving ultrasonic transmission efficiency by suppressing a decrease in sensitivity at the time of ultrasonic diagnosis in the stratum corneum at a measurement site. And providing ultrasonic diagnostic gel composition which is a coating type contact medium in which ultrasonic transmission efficiency improving composition is gelled, and using ultrasonic transmission efficiency improving composition and ultrasonic diagnostic gel composition An object is to provide a diagnostic method.
  • the present inventors have found that an aqueous solution containing one or more compounds that form vesicles in water before applying a coating-type contact medium for ultrasonic diagnosis to the skin.
  • a coating-type contact medium for ultrasonic diagnosis By applying to the skin, it was found that the ultrasonic transmission efficiency at the time of ultrasonic diagnosis was improved, and the ultrasonic transmission efficiency improving composition of the present invention was completed.
  • the gel composition for ultrasonic diagnosis as a coating-type contact medium for ultrasonic diagnosis was completed by adding a gelling agent etc. to this ultrasonic transmission efficiency improvement composition, and making it gelatinous.
  • the invention according to claim 1 relates to an ultrasonic transmission efficiency improving composition
  • an ultrasonic transmission efficiency improving composition comprising an aqueous solution containing one or more compounds that form vesicles in water.
  • an ultrasonic wave transmission efficiency improving composition comprising an aqueous solution containing one or more compounds that form vesicles in water to the skin and applying ultrasonic waves
  • Introducing hydrophilic lumps and breaking the homogenization of water makes it easier to supply moisture to the skin, and the vesicles with moisture itself also give moisture to the stratum corneum and improve the transmission efficiency of ultrasonic waves Therefore, ultrasonic waves are easily transmitted from the skin to the inside, and sensitivity during ultrasonic diagnosis can be improved.
  • the vesicle has bound water constrained by the hydrophilic mass, it is possible to suppress evaporation of moisture due to ultrasonic waves and prevent cavities generated at the time of ultrasonic diagnosis.
  • the vesicle-forming component comprises a sugar fatty acid ester, a polyoxyethylene hydrogenated castor oil derivative, a polyglycerin fatty acid ester, a phospholipid, a phospholipid polymer, mannosyl erythritol lipid, an acylamino acid metal salt, and a ceramide. It is an ultrasonic transmission efficiency improving composition selected from the group.
  • the vesicle-forming component comprises a sugar fatty acid ester, a polyoxyethylene hydrogenated castor oil derivative, a polyglycerin fatty acid ester, a phospholipid, a phospholipid polymer, mannosyl erythritol lipid, an acylamino acid metal salt, and a ceramide.
  • the aqueous solution contains at least one of fucose, glucose, glucuronic acid, and rhamnose as a constituent monosaccharide, and a polysaccharide containing fucose and / or rhamnose in the side chain is added to the total amount of the aqueous solution.
  • An ultrasonic transmission efficiency improving composition containing 0.005 wt% to 0.5 wt%.
  • the aqueous solution contains at least one of fucose, glucose, glucuronic acid, and rhamnose as a constituent monosaccharide, and contains a polysaccharide containing fucose and / or rhamnose in the side chain with respect to the total amount of the aqueous solution. 0.005% to 0.5% by weight is contained.
  • This polysaccharide has at least one of fucose, glucose, glucuronic acid, and rhamnose as a constituent monosaccharide, and has a moisturizing power with a polysaccharide containing fucose and / or rhamnose in the side chain.
  • this polysaccharide is not a vesicle but a nano-sized lump in water, it has the action of disrupting the continuity of water in the same way as a vesicle, so that the effect of the present invention can be improved. it can.
  • the blending amount of the polysaccharide is less than 0.005% by weight with respect to the total amount of the aqueous solution, the stratum corneum is less likely to be given moisture, and the flexibility of the stratum corneum may not be improved. If it is added in excess of% by weight, the above-mentioned polysaccharide may contain too much water, so that there will be no free water and water may not be given to the stratum corneum.
  • the invention according to claim 4 is an ultrasonic transmission efficiency improving composition in which the polysaccharide contains at least a polysaccharide represented by the following general formula (1).
  • the polysaccharide contains at least the polysaccharide represented by the general formula (1)
  • the aqueous solution containing the polysaccharide is excellent in water retention and excellent in the stability over time of the viscosity.
  • Ultrasonic transmission efficiency improving composition can be obtained, and viscosity and moisture can be maintained even during the use of ultrasonic diagnosis, so that the ultrasonic transmission efficiency can be improved and the sensitivity at the time of ultrasonic diagnosis can be improved. Can be maintained.
  • the invention according to claim 5 is the ultrasonic transmission efficiency improving composition comprising the vesicle-forming component in an amount of 0.005 to 3% by weight based on the total amount of the aqueous solution.
  • the vesicle-forming component since the vesicle-forming component is contained in an amount of 0.005 to 3% by weight with respect to the total amount of the aqueous solution, the vesicle-forming component can be reliably present in the aqueous solution, The vesicle having the water gives moisture to the stratum corneum, so that the transmission efficiency of ultrasonic waves can be improved, and the sensitivity at the time of ultrasonic diagnosis can be improved.
  • the vesicle-forming component When the vesicle-forming component is less than 0.005% by weight based on the total amount of the aqueous solution, the effect of vesicle formation may not be obtained. In addition, when the amount exceeds 3% by weight with respect to the total amount of the aqueous solution, not only an effect corresponding to the cost cannot be obtained, but also the water retention capacity of the vesicle becomes too large to supply moisture to the skin. .
  • the invention according to claim 6 is the ultrasonic transmission efficiency improving composition in which the particle size of the vesicle formed by the vesicle-forming component is in the range of 0.01 ⁇ m to 2.0 ⁇ m.
  • the particle size of the vesicle formed by the vesicle-forming component is in the range of 0.01 ⁇ m to 2.0 ⁇ m, the vesicle having moisture gives moisture to the stratum corneum and transmits ultrasonic waves. Efficiency can be improved and the sensitivity at the time of ultrasonic diagnosis can be improved.
  • the particle size of the vesicle is less than 0.01 ⁇ m, the vesicle lump itself does not have sufficient weight and does not generate enough energy to break the continuous hydrogen bond of water present in the stratum corneum. Until you can not give moisture.
  • the particle size of the vesicle exceeds 2.0 ⁇ m, the vesicle lump becomes too large and it becomes difficult to enter the intercellular lipid of the stratum corneum, and water cannot be given to the inside of the stratum corneum.
  • the invention according to claim 7 is the ultrasonic transmission efficiency improving composition characterized in that the aqueous solution contains 3- (2-ethylhexyloxy) propane-1,2-diol.
  • the aqueous solution contains 3- (2-ethylhexyloxy) propane-1,2-diol, familiarity with the skin is improved by reducing the surface tension of the aqueous solution containing vesicles. It is possible to promote the penetration of the aqueous solution into the stratum corneum. Therefore, the vesicle having moisture can impart moisture to the stratum corneum, thereby improving the transmission efficiency of ultrasonic waves, and improving the sensitivity during ultrasonic diagnosis.
  • 3- (2-ethylhexyloxy) propane-1,2-diol has an effect of effectively reducing the surface tension by blending a small amount.
  • the surface tension of a 0.25% aqueous solution of lipid-NR, which is an ultrasonic transmission efficiency improving composition of the present invention is 63.8 mN / m, and the surface tension when 20% of glycerin is blended is 61.9 mN / m. Almost no drop with m.
  • 0.25% of 3- (2-ethylhexyloxy) propane-1,2-diol is added thereto, the surface tension is reduced to 27.4 mN / m.
  • the blending amount is preferably 0.05% to 2%, more preferably 0.1% to 1%, and more preferably 0.2% to 0.5% with respect to the total amount of the composition. More preferably. If the blending amount is too large, the solubility becomes poor, and if the blending amount is small, the decrease in surface tension is small and the expected effect cannot be obtained.
  • the invention according to claim 8 contains the composition for improving ultrasonic transmission efficiency according to any one of claims 1 to 7, and is a carboxyvinyl polymer and / or (meth) acrylic acid / (meth) acrylic ester. It is a gel composition for ultrasonic diagnosis containing a copolymer and its salt in a gel form.
  • the gel composition for ultrasonic diagnosis contains a composition for improving ultrasonic transmission efficiency, and includes a carboxyvinyl polymer and / or (meth) acrylic acid / (meth) acrylic acid ester copolymer and the copolymer thereof. Since it contains a salt and is in the form of a gel, a good gel suitable for ultrasonic diagnosis can be obtained.
  • moisture-containing vesicles can give moisture to the stratum corneum and improve the transmission efficiency of ultrasonic waves. Can be improved.
  • this gel composition for ultrasonic diagnosis is suitable for ultrasonic diagnosis because it contains carboxyvinyl polymer and / or (meth) acrylic acid / (meth) acrylic acid ester copolymer and its salt in a gel form. Good gel properties can be obtained.
  • the composition for improving ultrasonic transmission efficiency of the present invention into a gel, dripping on the skin can be prevented.
  • the blending amount of the carboxyvinyl polymer is 0.05% by weight to 5.0% by weight with respect to the total amount of the gel composition for ultrasonic diagnosis, and the (meth) acrylic acid / (meth)
  • the ultrasonic diagnostic gel composition has a blending amount of acrylate copolymer and its salt of 0.05 to 5.0% by weight with respect to the total amount of the ultrasonic diagnostic gel composition.
  • the blending amount of the carboxyvinyl polymer is 0.05% by weight to 5.0% by weight with respect to the total amount of the gel composition for ultrasonic diagnosis, and (meth) acrylic acid / (meth) acrylic
  • the blending amount of the acid ester copolymer and its salt is 0.05% by weight to 5.0% by weight to 5.0% by weight with respect to the total amount of the gel composition for ultrasonic diagnosis.
  • the structure as the gel composition may not be configured. If it exceeds 5% by weight, the gel structure becomes too hard, which may cause problems in use. If the blending amount of (meth) acrylic acid / (meth) acrylic acid ester copolymer is less than 0.01% by weight, the structure as a gel composition may not be constituted. If it exceeds 0.5% by weight, the gel structure becomes too hard, which may cause a problem in use and the transparency of the gel may be lowered.
  • the invention according to claim 10 is an ultrasonic diagnosis in which the ultrasonic transmission efficiency improving composition according to any one of claims 1 to 7 is applied to the skin, and thereafter the ultrasonic transmission efficiency improving composition is not included as it is. Apply the gel composition for ultrasonic diagnosis, or after that, wipe the ultrasonic transmission efficiency improving composition and the ultrasonic diagnostic gel composition and do not contain the ultrasonic transmission efficiency improving composition.
  • or 7 is apply
  • the ultrasonic transmission efficiency improving composition is applied to the skin, so that the vesicles with water supply moisture to the stratum corneum and transmit ultrasonic waves. Efficiency can be improved, ultrasonic waves are easily transmitted from the skin to the inside, and sensitivity during ultrasonic diagnosis can be improved.
  • the ultrasonic diagnostic gel composition which does not contain the ultrasonic transmission efficiency improving composition by applying the ultrasonic transmission efficiency improving composition to the skin and then wiping the ultrasonic transmission efficiency improving composition and the ultrasonic diagnostic gel composition.
  • the vesicle having moisture formed by the already applied ultrasound transmission efficiency improving composition may give moisture to the stratum corneum and improve the ultrasound transmission efficiency.
  • ultrasonic waves are easily transmitted from the skin to the inside, and sensitivity during ultrasonic diagnosis can be improved.
  • the invention according to an eleventh aspect is an ultrasonic diagnostic method in which the ultrasonic diagnostic gel composition according to the eighth or ninth aspect is applied to the skin, and then an ultrasonic diagnosis is performed as it is.
  • the gel composition for ultrasonic diagnosis of Claim 8 or Claim 9 is apply
  • the ultrasonic diagnostic gel composition contains an ultrasonic transmission efficiency improving composition, and the vesicles having moisture formed by the ultrasonic transmission efficiency improving composition give moisture to the stratum corneum, The transmission efficiency of ultrasonic waves can be improved, the ultrasonic waves can be easily transmitted from the skin to the inside, and the sensitivity at the time of ultrasonic diagnosis can be improved.
  • the composition for improving ultrasonic transmission efficiency of the present invention is applied to the skin, and a gelling agent or the like is added to the composition for improving ultrasonic transmission efficiency.
  • a gelling agent or the like is added to the composition for improving ultrasonic transmission efficiency.
  • Comparative example A photograph of the result of Doppler display using G-1.
  • Example Photograph of the results of Doppler display using Example 47.
  • the present invention relates to an ultrasonic transmission efficiency improving composition containing a component for improving ultrasonic transmission efficiency at the time of ultrasonic diagnosis, and an ultrasonic wave that is a coating-type contact medium in which the ultrasonic transmission efficiency improving composition is gelled.
  • the present invention relates to a diagnostic gel composition and an ultrasonic diagnostic method.
  • a conventional coating-type contact medium for ultrasonic diagnosis contains many polyhydric alcohols and hydrophilic polymers, and water binds to polar groups such as hydroxyl groups, carboxyl groups, and amino groups of these compounds. Such water is called bound water and is bound by a polymer or a polyhydric alcohol. Therefore, it turns out that the water contained in a contact medium is hard to be supplied to skin. In addition, water itself is connected by hydrogen bonds, and the apparent molecular weight is greatly uniformed.
  • the present inventor has removed water from polyhydric alcohol and hydrophilic polymer, and by putting a hydrophilic mass in the water, water is lost to the skin by breaking the homogenization of the water. A method for facilitating supply was found and the present invention was completed. Furthermore, the hydrophilic mass of the present invention has bound water around itself and enters the stratum corneum as it is. Thereby, not only the water reaches the stratum corneum but also the bound water constrained by the hydrophilic mass, so that it is possible to prevent the evaporation of water due to the ultrasonic wave at the time of ultrasonic diagnosis.
  • an ultrasonic transmission efficiency improving composition comprising an aqueous solution containing one or more compounds that form vesicles in water is applied and applied to the skin in order to put a hydrophilic mass in water.
  • Ultrasonic transmission efficiency improving composition by putting a hydrophilic mass in the water, breaking the homogenization of the water makes it easier to supply moisture to the skin, and the vesicles with moisture give the stratum corneum moisture
  • the transmission efficiency of ultrasonic waves can be improved, and the ultrasonic waves can be easily transmitted from the skin to the inside, and the sensitivity at the time of ultrasonic diagnosis can be improved.
  • the vesicle since the vesicle has bound water constrained by the hydrophilic mass, it is possible to suppress evaporation of moisture due to ultrasonic waves and prevent cavities generated at the time of ultrasonic diagnosis.
  • the vesicle is preferably contained in an amount of 0.005 to 3% by weight based on the aqueous solution.
  • the blending amount of the vesicle-forming amphiphilic compound is preferably 0.01% by weight or more, more preferably 0.025% by weight or more based on the total amount of the composition. If the amount of the vesicle-forming amphiphilic compound is too small, the effect of vesicle formation may not be obtained. Further, if it is 3% by weight or more, not only the effect corresponding to the cost cannot be obtained, but also the vesicle retains water, and it becomes impossible to supply moisture to the skin. In order to obtain an efficient effect, the content is preferably 1% by weight or less, more preferably 0.5% by weight or less.
  • the vesicle formed by the composition for improving ultrasonic transmission efficiency of the present invention preferably contains a vesicle having a particle size of 0.01 ⁇ m to 2.0 ⁇ m.
  • the particle size of the vesicle is about 0.005 ⁇ m to 5.0 ⁇ m in a normal aqueous solution. In the present invention, it is preferably 0.01 ⁇ m to 1 ⁇ m, and more preferably 0.02 ⁇ m to 0.5 ⁇ m.
  • the hydrophilic mass in the present invention if the diameter is large, the water molecular weight and the force to be constrained are increased, and the effect of the present invention is increased. However, if the diameter of the hydrophilic mass is too large, it will not penetrate into the stratum corneum.
  • the diameter of the vesicle which is a suitable hydrophilic mass for effectively realizing the present invention, is 0.01 ⁇ m to 2.0 ⁇ m. Moreover, since the polysaccharide of the present invention is not a vesicle but is agglomerated in water, the effect of the present invention is further improved.
  • the vesicle having moisture can impart moisture to the stratum corneum, so that the transmission efficiency of ultrasonic waves can be improved, and the sensitivity at the time of ultrasonic diagnosis can be improved.
  • the particle size of the vesicle is less than 0.01 ⁇ m, the vesicle lump itself does not have sufficient weight and does not generate enough energy to break the continuous hydrogen bond of water present in the stratum corneum. Until you can not give moisture.
  • the particle size of the vesicle exceeds 2.0 ⁇ m, the vesicle lump becomes too large and it becomes difficult to enter the intercellular lipid of the stratum corneum, and water cannot be given to the inside of the stratum corneum.
  • the vesicle-forming component is selected from the group consisting of sugar fatty acid ester, polyoxyethylene hydrogenated castor oil derivative, polyglycerin fatty acid ester, phospholipid, phospholipid polymer, mannosyl erythritol lipid, biosurfactant, acylamino acid metal salt, and ceramide. Can be used.
  • the vesicle-forming compound is at least partially present as a vesicle in the aqueous composition according to the present invention.
  • Vesicles can be easily formed by a known method.
  • a vesicle composed of a vesicle-forming compound can be formed in water by mixing and stirring a vesicle-forming compound and water.
  • sugar fatty acid ester examples include sucrose fatty acid ester, maltitol fatty acid ester, trehalose fatty acid ester and the like.
  • the number of hydroxyl groups substituted with fatty acid is not particularly limited, but monoesters, diesters and triesters are preferred, monoesters and diesters are more preferred, and monoesters are most preferred.
  • the constituent fatty acid in the sugar fatty acid ester is a saturated or unsaturated fatty acid having 12 to 22 carbon atoms, and preferably has a straight chain or a branched chain.
  • fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, arachidic acid, behenic acid, tetradecenoic acid, hexadecenoic acid, octadecenoic acid, octadecadienoic acid, eicosenoic acid, eicosatetraenoic acid, Examples include docosenoic acid and octadecatrienoic acid. Of these, stearic acid is preferred. In the case of a diester, the two fatty acids may be different.
  • the polyoxyethylene hydrogenated castor oil derivative is produced by hydrogenating castor oil and subjecting ethylene oxide to addition polymerization.
  • HLB changes with the number of ethylene oxide.
  • the HLB is preferably HLB 10 to 15, more preferably HLB 11 to 14.
  • the polyglycerin fatty acid ester is an ester bond of polyglycerin and a fatty acid, but the fatty acid is not particularly limited.
  • the fat extracted from natural animals and plants is hydrolyzed and separated or It can be obtained by purification without separation, and may be saturated, unsaturated or mixed, but is preferably saturated, more preferably selected from the group consisting of myristic acid, palmitic acid and stearic acid At least one, most preferably stearic acid is used.
  • the degree of polymerization of the polyglycerol fatty acid ester is not particularly limited, but the average degree of polymerization is 2 to 20, preferably 4 to 10, and more preferably 5 to 10.
  • the polyglycerol fatty acid ester has a molar average esterification degree of preferably 3.0 or less, more preferably 2.0 or less, and most preferably 1.5 or less. When the purity is 100%, the molar average esterification degree is 1 for monoester and 2 for diester.
  • the average by the weight ratio is the molar average degree of esterification.
  • the average degree of esterification is 1.5 as the weight average.
  • the HLB of the polyglycerol fatty acid ester in the present invention is preferably HLB 9 to 16, more preferably HLB 11 to 14.
  • Preferred examples of phospholipids include those selected from lecithin, phosphatidylglycerol, phosphatidylserine, phosphatidylinositol, phosphatidylethanolamine, phosphatidylic acid, and lyso forms thereof.
  • lecithin is a common name for phospholipids containing phosphatidylcholine as a main component.
  • phosphatidylcholine as a main component can also be used.
  • soybean, egg yolk and the like can be preferably exemplified, and soybean can be particularly preferably exemplified.
  • such a phospholipid can contain only one species, or can contain two or more species in combination.
  • phospholipid polymer there is 2-methacryloyloxyethyl phosphorylcholine shown in the following “Chemical Formula 2”, and as a commercially available product, there is Lipidure-NR (manufactured by NOF Corporation).
  • acyl amino acid metal salt examples include sodium N-lauroyl-L glutamate, sodium N-stearoyl-L glutamate, sodium di (N-lauroylglutamyl) lysine, sodium lysine dilauroylglutamate, and the like.
  • a commercially available product is Perisea L-30 (manufactured by Asahi Kasei Chemicals Corporation).
  • Biosurfactants include mannosyl erythritol lipids that produce natural vesicles made by yeast.
  • Mannosylerythritol lipid is a compound having a structure in which erythritol is substituted at the 1st position of mannose, an acyl group is substituted at the 2nd and 3rd positions, and an acetyl group may be substituted at the 4th and 6th positions. is there.
  • a commercial product is CERAMELA-PX (manufactured by Toyobo Co., Ltd.).
  • the ceramide which is a vesicle-forming component of the present invention, has types of ceramide 1 to 7 due to its structure, and any of these can be used in the present invention.
  • ceramide 2 and / or ceramide 3 can be exemplified as a more preferable one, and ceramide 2 is particularly preferable.
  • Such ceramides are already commercially available as raw materials for external preparations for skin, and in the present invention, such commercially available products can be purchased and used.
  • ceramide As ceramide as a cosmetic raw material on the market, "Ceramide 2" (Ceramide 2) (COSMO FARM), “Ceramide III” (CERAMID 3) (COSMO FARM), “Ceramide IIIA” (Ceramide 3) ) (Manufactured by Cosmo Farm), “Ceramide IIIB” (ceramide 3), “Ceramide VI” (ceramide 6) (manufactured by Cosmo Farm) and “Ceramide TTI-001” (ceramide 2) (manufactured by Takasago International Corporation) ) Sphingomonas extract, cerebroside, sphingomyelin and the like exist.
  • an aqueous solution is suitable because it is preferably applied to the skin and the probe after measurement is preferably easily cleaned.
  • a polyhydric alcohol is blended for the purpose of improving the familiarity with the skin.
  • the polyhydric alcohol include ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-propanediol, glycerin, 1,2-butanediol, 1, which are known as coating-type contact media for ultrasonic diagnosis.
  • 1,3-propanediol, glycerin, diglycerin, 1,3-butanediol, 1,2-pentanediol More preferably, one propylene glycol or two or more propylene glycols are blended in an amount of 5.0 to 50.0% by weight with respect to the ultrasonic transmission efficiency improving composition or the coating type contact medium for ultrasonic diagnosis. It is more desirable to add 10.0 to 30.0% by weight, and this has led to the main part of the present invention.
  • the aqueous solution preferably contains a polysaccharide.
  • a polysaccharide By making polysaccharides at least one of fucose, glucose, glucuronic acid, and rhamnose as a constituent monosaccharide, and using polysaccharides that contain fucose and / or rhamnose in the side chain, The effect of the present invention can be improved by supplementing the flexibility and moisture content of the stratum corneum.
  • the polysaccharide is preferably contained in the composition for improving ultrasonic transmission efficiency of the present invention in an amount of 0.005 to 0.5% by weight, more preferably 0.01 to 0.2% by weight, and particularly preferably 0.02%. ⁇ 0.1% by weight. If it is less than 0.005% by weight, the flexibility of the stratum corneum may not be improved. If it is blended by 0.5% by weight or more, the polysaccharide of the present invention will contain too much water and free water will disappear, and the stratum corneum will have moisture. May not be able to give.
  • the polysaccharide of the present invention is preferably a polysaccharide containing at least a polysaccharide represented by the following general formula (2).
  • the polysaccharide represented by the following general formula (2) is marketed by Hakuto Co., Ltd. as “trade name: Arcacylan, cosmetic label: Alkaligenes-producing polysaccharide”.
  • the polysaccharide of the present invention is known as a cosmetic raw material, and Japanese Patent Application Laid-Open No. 5-85925 discloses a polysaccharide of the present invention and 3 water-soluble polyhydric alcohols having two or more hydroxyl groups in the molecule. It is disclosed that by using a combination of ⁇ 40% by weight, a cosmetic with no stickiness and excellent moisturizing properties is provided.
  • Japanese Patent Application Laid-Open No. 2002-60314 discloses that a specific polysaccharide is blended in a skin external preparation containing a medicinal component or a functional component to improve the stability over time of viscosity and the skin feel.
  • An external preparation for skin is disclosed.
  • Japanese Patent Application Laid-Open No. 2003-89624 discloses a conditioner that improves the yield of active ingredients in hair, imparts “smoothness” and “moistness” to hair, and improves the hair damage suppression effect.
  • a hair cosmetic is disclosed.
  • Patent document No. 4902212 discloses that the polysaccharide of the present invention in an aqueous solution is present as particles having an average particle diameter of 8 nm to 500 nm.
  • the ultrasonic transmission efficiency improving composition of the present invention preferably contains 3- (2-ethylhexyloxy) propane-1,2-diol.
  • 3- (2-ethylhexyloxy) propane-1,2-diol has the effect of effectively reducing the surface tension when blended in a small amount.
  • the surface tension of a 0.25% aqueous solution of lipid-NR which is the ultrasonic transmission efficiency improving composition of the present invention, is 63.8 mN / m, and the surface tension when 20% of glycerin is blended is 61.9 mN / m. Almost no drop with m.
  • 0.25% of 3- (2-ethylhexyloxy) propane-1,2-diol is added thereto, the surface tension is reduced to 27.4 mN / m.
  • the blending amount of 3- (2-ethylhexyloxy) propane-1,2-diol is preferably 0.05% to 2%, more preferably 0.1% to 1% with respect to the total amount of the composition. More preferably, the content is 0.2% to 0.5%. If the blending amount is too large, the solubility becomes poor, and if the blending amount is small, the decrease in surface tension is small and the expected effect cannot be obtained.
  • the composition for improving ultrasonic transmission efficiency of the present invention includes at least carboxyvinyl polymer and / or polyvinyl alcohol, (meth) acrylic acid / ( It is preferable to apply as a coating-type contact medium for ultrasonic diagnosis by blending a meth) acrylic acid ester copolymer and a salt thereof into a gel-like form.
  • the ultrasonic transmission efficiency improving composition of the present invention can be applied to the aqueous solution and then applied to the skin before applying the application type contact medium for ultrasonic diagnosis to the skin.
  • the application type contact medium for ultrasonic diagnosis is applied after the application of the aqueous solution of the ultrasonic transmission efficiency improving composition of the present invention, which is troublesome twice. Therefore, in order to improve the simplicity and practicality of the operation, the composition for improving ultrasonic transmission efficiency of the present invention can be blended in a coating type contact medium for ultrasonic diagnosis. The operation is simple and practical.
  • the carboxyvinyl polymer used in the present invention is mainly a polymer of acrylic acid, and specific examples thereof are not particularly limited and can be appropriately selected depending on the purpose.
  • Hibiswako 103 manufactured by Wako Pure Chemical Industries, Ltd.
  • Hibiswako 104 manufactured by Wako Pure Chemical Industries, Ltd.
  • Hibiswako 105 manufactured by Wako Pure Chemical Industries, Ltd.
  • AQUPEC HV-501E (Sumitomo) Seika Chemicals Co., Ltd.)
  • AQUPEC HV-805EG Sumitomo Seika Co., Ltd.
  • Sakai HV-504E Siliconitomo Seika Co., Ltd.
  • AQUPEC HV-505E Sumitomo Seika Co., Ltd.
  • Carbo Paul 981 manufactured by Lubrizol
  • Carbopol 980 manufactured by Lubrizol
  • Carbopol 941 (manufactured by Lubrizol)
  • carboxyvinyl polymer components can be used.
  • the carboxyvinyl polymer is usually used after neutralization with a basic substance.
  • the basic substance to be used include alkanolamines such as triethanolamine and monoethanolamine, inorganic bases such as ammonia, sodium hydroxide and potassium hydroxide, and basic amino acids such as arginine.
  • the addition amount of the basic substance is an amount sufficient to neutralize the carboxyvinyl polymer component, and may be appropriately blended according to the type and amount of use of these components.
  • the (meth) acrylic acid / (meth) acrylic acid ester copolymer used in the ultrasonic diagnostic gel composition of the present invention comprises at least one monomer composed of acrylic acid, methacrylic acid or a simple ester thereof, and alkyl acrylate. It is a copolymer. It is known as an INCI name: Acrylates / C10-30 Alkyl Acrylate Crosspolymer [(acrylic acid / acrylic acid (C 10-30) alkyl) crosspolymer], etc., and a commercially available product can be used.
  • the (meth) acrylic acid / (meth) acrylic acid ester copolymerization component of this invention can be used for the (meth) acrylic acid / (meth) acrylic acid ester copolymerization component of this invention.
  • the (meth) acrylic acid / (meth) acrylic acid ester copolymer component soot is usually used after neutralization with a basic substance.
  • the basic substance to be used include alkanolamines such as triethanolamine and monoethanolamine, inorganic bases such as ammonia, sodium hydroxide and potassium hydroxide, and basic amino acids such as arginine.
  • the amount of the basic substance added is sufficient to neutralize the (meth) acrylic acid / (meth) acrylic acid ester copolymer component, and may be appropriately blended depending on the type and amount of use of these components. That's fine.
  • the structure as the gel composition may not be configured. If it exceeds 5% by weight, the gel structure becomes too hard, which may cause problems in use. If the blending amount of (meth) acrylic acid / (meth) acrylic acid ester copolymer is less than 0.01% by weight, the structure as a gel composition may not be constituted. If it exceeds 0.5% by weight, the gel structure becomes too hard, which may cause a problem in use and the transparency of the gel may be lowered.
  • the above-mentioned gel composition for ultrasonic diagnosis contains a composition for improving ultrasonic transmission efficiency, and contains a carboxyvinyl polymer and / or (meth) acrylic acid / (meth) acrylic acid ester copolymer and a salt thereof in a gel form. It is said. For this reason, the composition for improving ultrasonic transmission efficiency is blended in an application type contact medium for ultrasonic diagnosis, and the gel composition for ultrasonic diagnosis is applied to the skin once so that the vesicle having moisture becomes a stratum corneum. Water can be given to the ultrasonic wave to improve the transmission efficiency of ultrasonic waves, and the sensitivity during ultrasonic diagnosis can be improved.
  • the above-mentioned gel composition for ultrasonic diagnosis contains a carboxyvinyl polymer and / or a (meth) acrylic acid / (meth) acrylic acid ester copolymer and a salt thereof, and has a gel-like shape, so that good gel properties are obtained. Can do.
  • the composition for improving ultrasonic transmission efficiency of the present invention into a gel, dripping on the skin can be prevented.
  • thickeners include plant polymers such as gum arabic, tragacanth, galactan, carob gum, guar gum, caraya gum, carrageenan, pectin, agar, alge colloid, fucoidan, trant gum, locust bean gum, galactomannan, xanthan gum, curdlan , Microbial polymers such as gellan gum, fucogel, dextran, succinoglucan, pullulan, diyutan gum, and animal (including fish) polymers such as chitosan, casein, albumin, gelatin, collagen, hydrolyzed collagen, Starch-based polymers such as starch, carboxymethyl starch, methylhydroxypropyl starch, methylcellulose, ethylcellulose, methylhydroxypropylcellulose, carboxymethylcellulose, hydroxymedium Cellulose polymers such as cellulose, hydroxypropyl cellulose, nitrocellulose, sodium cellulose sulfate, sodium carb
  • flexibility and moisture to skin can be mix
  • Ingredients that soften and moisturize the skin that can be blended in the present invention are those that can be used in ordinary cosmetics or drugs for skin application, and are not particularly limited as long as they are used alone or as a mixture thereof.
  • Mucopolysaccharides such as hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin and keratan sulfate or salts thereof, proteins such as collagen, hydrolyzed collagen, elastin, keratin or derivatives thereof and salts thereof, honey, erythritol , Maltose, maltitol, xylitol, xylose, pentaerythritol, fructose, dextrin and its derivatives, saccharides such as mannitol, sorbitol, inositol, trehalose, glucose, urea, asparagine, aspartic acid, alani Arginine, isoleucine, ortinine, glutamine, glycine, glutamic acid and derivatives thereof and salts thereof, cysteine, cystine, citrulline, threonine,
  • the present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.
  • the blending amount is expressed in% by weight based on the system in which the component is blended.
  • the components used in the examples are as follows. The components are indicated by A-1, B-1, etc. as follows.
  • Vesicle-forming component A-1 Polyoxyethylene hydrogenated castor oil [trade name “NIKKOL HCO-30” (HLB11) (manufactured by Nikko Chemicals Corporation)
  • A-2 Polyoxyethylene hydrogenated castor oil [trade name “NIKKOL HCO-60” (HLB14) (manufactured by Nikko Chemicals Co., Ltd.)
  • A-4 Sphingomonas extract [Brand name "Biocera G” (manufactured by Dainippon Kasei Co., Ltd.)
  • A-5 Sphingomyelin [Product name "Milk Ceramide 4G” (manufactured by Yamakawa Trading Co., Ltd.)
  • Comparative Example Component G-1 Coating type contact medium (trade name: Echo Jelly, manufactured by Hitachi Aloka Medical Co., Ltd.)
  • the adjustment method of the measurement sample in the following examples and comparative examples is as follows. 1. In a 500 ml beaker, the active ingredient was adjusted to 10%. A-1 to A-10 were dispersed in water to make a total of 300 g, and then a vesicle was formed to prepare a vesicle solution. . 2. Into a 500 ml beaker, put 288 g of purified water and start stirring with a disperser. 1.2 g of C-2 was added thereto, and stirred at 5000 rpm for 10 minutes to obtain a polymer dispersion. 3.
  • the measurement of the vesicle particle size in the following Examples and Comparative Examples is as follows.
  • the particle diameter of the aqueous vesicle dispersion formed above was measured using a concentrated particle size analyzer FPAR-1000 (manufactured by Otsuka Electronics Co., Ltd.).
  • FPAR-1000 manufactured by Otsuka Electronics Co., Ltd.
  • 1 g of a sample and 99 g of purified water are weighed in a beaker and stirred with a magnetic stirrer for 1 hour.
  • an appropriate amount of the resulting solution is put into a measurement cell, a probe is attached, and measurement is started. About the same sample, it measured 3 times and took out the average value.
  • the measurement of the ultrasonic intensity in Examples and Comparative Examples is as follows. 1. Measuring device a. Transceiver D-56 Wuppertal 1ECHOMETR 1060 (manufactured by KARRL DETSCH) b. Vibrator DS12HB 1-6 (1-6MHz) (manufactured by KARL DETSCH) c. Standoff 2 mm thick matching layer Measurement location Lower leg or forearm 3. Measurement Method A reflection intensity signal reflected from the skin surface was obtained by the above-described measurement apparatus, and a change in the reflection intensity signal intensity before and after application of the ultrasonic transmission efficiency improving composition was measured.
  • Evaluation of the composition for improving ultrasonic transmission efficiency is as follows. 1.
  • the ultrasonic transmission efficiency improving composition adjusted by the above method is immersed in cotton and then adhered to the measurement site for 3 minutes. After adhering, wipe the surface with tissue to remove moisture (or leave it as it is). Next, after applying and stretching an ultrasonic measurement gel, the ultrasonic measurement probe is applied to the skin and the reflected signal intensity (Vpp value) of the ultrasonic wave is measured.
  • the ultrasonic measurement probe of the present invention is applied to the skin and the reflected signal intensity of the ultrasonic wave ( Vpp value) was measured.
  • the ultrasonic diagnostic image of the gel composition for ultrasonic diagnosis of the present invention was evaluated.
  • an ultrasonic diagnostic device used ProSound ⁇ 7 (manufactured by Hitachi Aloka), and as a probe, UST-567 (manufactured by Hitachi Aloka) was used.
  • Evaluations for Examples 1 to 7 are as follows. Evaluation of Composition for Improving Ultrasonic Transmission Efficiency The ultrasonic transmission efficiency improving composition adjusted with the components used in the above examples is immersed in cotton and then adhered to the measurement site for 3 minutes. After adhesion, wipe the surface with tissue to remove moisture. Next, after applying and stretching the gel G-1 for ultrasonic measurement, the reflected signal intensity of the ultrasonic wave was measured by applying the ultrasonic measurement probe to the skin by the measurement method described above. The results are shown in Table 1 for the examples and in Table 2 for the comparative examples. In the following table, the leftmost column shows the above components.
  • Comparative Example 6 was the result of not applying the composition for improving the ultrasonic transmission efficiency, and the reflected signal intensity was 0.30 mV. By adding the compound used in the present invention, the reflected signal intensity decreased. In addition, from the results of Comparative Examples 1 and 2, it was confirmed that the penetration of energy into the skin was improved by 10% by blending a polyhydric alcohol such as glycerin as disclosed in Patent Document 1. .
  • Examples 1 and 2 show the results of the composition for improving ultrasonic transmission efficiency in which Pericea L-30, which is a vesicle-forming component of the present invention, was blended. Even when compared with Comparative Example 1, the result that the penetration of energy into the skin was improved by 33% or more was obtained.
  • Example 3 the penetration of energy into the skin was further improved by blending the alkathylan of the present invention, 3- (2-ethylhexyloxy) propane-1,2-diol.
  • Examples 5 and 6 the effects of the present invention were further promoted by adding glycerin and 1,3-propanediol to the present invention. Also, as shown in Example 7, by simultaneously blending glycerin and 1,3-propanediol, the reflected signal intensity became 0.15 mV with a low addition amount, and the transmission of energy to the skin was improved by 50%. It was obtained.
  • the evaluation for Examples 8 to 17 is as follows. Evaluation of Composition for Improving Ultrasonic Transmission Efficiency The ultrasonic transmission efficiency improving composition adjusted with the components used in the above examples is immersed in cotton and then adhered to the measurement site for 3 minutes. After adhesion, wipe the surface with tissue to remove moisture. Next, after applying and stretching the gel G-1 for ultrasonic measurement, the reflected signal intensity of the ultrasonic wave was measured by applying the ultrasonic measurement probe to the skin by the measurement method described above. The results are shown in Table 3.
  • Example 8 the difference in the reflected signal intensity reduction effect by the component forming the vesicle of the present invention was compared.
  • the vesicle-forming component NIKKOL HCO-30 in Example 8 and the vesicle-forming component NIKKOL HCO-60 in Example 9 formed a small vesicle with an average particle size of 0.1 ⁇ m or less, and the reflected signal intensity was also 0. The penetration of ultrasonic energy into skin with 2 or less is also good.
  • the vesicle-forming component Biocera G of Example 11 in which the average particle size of the vesicles is 0.3 ⁇ m or less, the vesicle-forming component Pericea L-30 of Example 13, the vesicle-forming component lipida-NR of Example 14, and Example 15
  • the vesicle-forming component CERAMELA-PX has a reflected signal intensity of 0.2 or less, and the penetration of ultrasonic energy into the skin is good.
  • the reflected signal intensity of the vesicle-forming component milk ceramide 4G of Example 12 in which the average particle size of the vesicle is 0.3 to 0.5 ⁇ m and the vesicle-forming component Surf Hope SE COSME C-1811 of Example 16 is 0.21. Reflection intensity increases.
  • the reflected signal intensity of Example 17 is 0.24.
  • the effect of the composition for improving ultrasonic transmission efficiency of the present invention varies depending on the combination of various components, but the average particle size of the vesicle is preferably 1.0 ⁇ m or less, and more preferably 0.5 ⁇ m or less. There was found.
  • the evaluation for Examples 18 to 24 is as follows. Evaluation of Composition for Improving Ultrasonic Transmission Efficiency The ultrasonic transmission efficiency improving composition adjusted by the above adjustment method is immersed in cotton and then adhered to the measurement site for 3 minutes. After adhesion, wipe the surface with tissue to remove moisture. Next, after applying and stretching the gel G-1 for ultrasonic measurement, the reflected signal intensity of the ultrasonic wave was measured by applying the ultrasonic measurement probe to the skin by the measurement method described above. The results are shown in Table 4.
  • Example 18 In Examples 18 to 24, combinations of the components forming the vesicle of the present invention were performed.
  • the reflection signal intensity of Example 19 in which the vesicle-forming component NIKKOL HCO-30 and the vesicle-forming component Perisea L-30 were combined was as low as 0.14 mV, and the ultrasonic energy was highest and transmitted through the skin.
  • the reflection signal intensity of Example 8 with the NIKKOL HCO-30 compounding alone is 0.19 mV
  • the reflection signal intensity of Example 13 with the Perisea L-30 compounding alone is 0.16 mV.
  • the synergistic effect of combining two vesicle-forming components The effect was recognized.
  • Example 19 the average particle size of vesicles is a combination of 0.01216 ⁇ m (Example 8) and 0.163 ⁇ m (Example 13), and the presence of vesicles of different sizes causes a hydrogen bonding state in the aqueous phase. It is presumed that due to the increase in the non-uniformity of the water, the water binding force decreased and the penetration into the skin increased.
  • the combination of the vesicle-forming component NIKKOL HCO-30 and the vesicle-forming component NIKKOL HCO-60 in Example 18 or the combination of the vesicle-forming component Perisea L-30 and the vesicle-forming component Lipidia-NR in Example 23 is the average particle size of the vesicle.
  • Example 24 in which the three components were combined, vesicles having different sizes were mixed, so it is estimated that a synergistic effect of the combination was obtained.
  • the evaluation for Examples 25 to 30 is as follows. Evaluation of Composition for Improving Ultrasonic Transmission Efficiency The composition for improving ultrasonic transmission efficiency adjusted by the adjustment method described above is immersed in cotton, then adhered to the measurement site, and the cotton is removed after 3 minutes. Next, after applying and extending the ultrasonic measurement gel G-1 while the composition for improving the ultrasonic transmission efficiency remains on the skin surface, the ultrasonic measurement probe is applied to the skin by the measurement method described above. The reflected signal intensity of the ultrasonic wave was measured. The results are shown in Table 5.
  • the blending concentration of the component lipid-NR forming the vesicle of the present invention was changed. In the range of 0.05% to 0.5%, the reflected signal intensity was the same, but in the case of 0.01%, 1%, and 3%, the reflected signal intensity increased slightly. In addition, the composition of polyhydric alcohol components B-1, B-2, B-4, and B-5 was changed, but this concentration did not particularly affect the reflected signal intensity.
  • Examples 31 to 44 are as follows. Evaluation of gel composition for ultrasonic diagnosis After applying the gel composition for ultrasonic diagnosis of the present invention to the measurement site and extending it, the probe for ultrasonic measurement is applied to the skin and the reflected signal intensity of the ultrasonic wave is measured. did. As a comparative example, G-1 echo jelly was used (Comparative Example-6). The results are shown in Table 6.
  • the reflected signal intensity of Comparative Example 6 was 0.30 mV.
  • Examples 31 to 44 showed low reflected signal intensity, and therefore the gel composition for ultrasonic diagnosis of the present invention has a skin with ultrasonic energy compared to the application-type contact medium of Comparative Example.
  • the permeability was significantly improved.
  • NIKKOL HCO-30 was blended as a vesicle-forming component, and the types and blending amounts of the gelling agent and thickening agent were changed, but no significant change was observed in the reflected signal intensity value. From these results, it was suggested that the gelling agent and the thickening agent should be selected according to the gel viscosity, the feeling of use and the ease of use.
  • Example 38 NIKKOL HCO-60, Perisea L-30, and Lipidure NR were blended as vesicle forming components, and the blending amount of polyhydric alcohol was increased.
  • Example 39 to 43 when the amount of glycerin and 1,3-propanediol was increased to 20 and 25%, the reflected signal intensity was significantly decreased.
  • Example 40 when 10% glycerin and 10% 1,3-propanediol were blended, the reflected signal intensity decreased significantly to 0.13 mV, and the permeability of ultrasonic energy to the skin was further improved.
  • Example 44 is an example in which CERAMELA-PX was used as a vesicle-forming component and 40% glycerin was blended, but there was no effect of increasing the amount of polyhydric alcohol, but rather an increase in reflected signal intensity was observed.
  • Evaluations for Examples 45, 46, and 47 are as follows. Images of gel compositions for ultrasonic diagnosis of the present invention were compared by the above comparison method. As a comparative example, an echo gel of G-1 was used. 2 subjects Female Test site is abdomen and lower leg
  • Example 45 was neutralized with 4.2 g of 10% aqueous KOH solution.
  • Example 46 was neutralized with 4.2 g of 10% NaOH aqueous solution.
  • Example 47 was neutralized with 4.2 g of 10% NaOH aqueous solution.
  • FIG. 1 is a photograph when the comparative example G-1 is applied
  • FIG. 2 is a photograph when the example 47 is applied.
  • the image was sharper, the depth was confirmed, the multiple reflection was small, and the signal intensity of Doppler was high.
  • the evaluation is as follows.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne une composition permettant d'augmenter le rendement de transmission ultrasonore qui peut supprimer, pendant le diagnostic par ultrasons, une diminution de la sensibilité dans la couche cornée au niveau d'un site surveillé et ainsi augmenter l'efficacité de transmission ultrasonore ; une composition de gel pour diagnostic par ultrasons qui est un milieu de contact de type revêtement préparé par gélification de la composition permettant d'augmenter le rendement de transmission ultrasonore ; et un procédé de diagnostic. La composition d'augmentation de l'efficacité de transmission ultrasonore comprend une solution aqueuse qui contient une ou plusieurs sortes de composés aptes à former des vésicules dans l'eau. La composition de gel pour diagnostic par ultrasons est un milieu de contact de type revêtement qui est préparé par gélification de la composition précitée afin d'augmenter le rendement de transmission ultrasonore. Le procédé de diagnostic comprend l'utilisation de la composition précitée.
PCT/JP2016/079246 2016-03-04 2016-10-03 Composition pour augmenter le rendement de transmission ultrasonore, composition de gel pour diagnostic par ultrasons et procédé de diagnostic par ultrasons WO2017149819A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201680083158.7A CN109069129B (zh) 2016-03-04 2016-10-03 用于提高超声波传输效率的组合物、超声波诊断用凝胶组合物、以及超声波扫描方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016042251A JP6130538B1 (ja) 2016-03-04 2016-03-04 超音波伝達効率向上組成物、超音波診断用ゲル組成物及び超音波撮影方法
JP2016-042251 2016-03-04

Publications (1)

Publication Number Publication Date
WO2017149819A1 true WO2017149819A1 (fr) 2017-09-08

Family

ID=58714806

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2016/079246 WO2017149819A1 (fr) 2016-03-04 2016-10-03 Composition pour augmenter le rendement de transmission ultrasonore, composition de gel pour diagnostic par ultrasons et procédé de diagnostic par ultrasons

Country Status (3)

Country Link
JP (1) JP6130538B1 (fr)
CN (1) CN109069129B (fr)
WO (1) WO2017149819A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6853127B2 (ja) 2017-06-28 2021-03-31 株式会社クボタ 歩行型作業機
CN109806277B (zh) * 2018-12-30 2020-12-11 浙江大学 一种金属纳米复合物及其制备方法和应用
CN110327473B (zh) * 2019-08-13 2021-10-26 湖州市中心医院 一种医用超声耦合垫粉末及其使用方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11318898A (ja) * 1998-05-14 1999-11-24 Pola Chem Ind Inc 超音波診断用ゲル組成物
JP2001097847A (ja) * 1999-09-29 2001-04-10 Pola Chem Ind Inc ゲル組成物の製造法
JP2011213646A (ja) * 2010-03-31 2011-10-27 Noevir Co Ltd ゲル組成物
JP2015224326A (ja) * 2014-05-29 2015-12-14 住友精化株式会社 超音波媒体用組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1824521B1 (fr) * 2004-11-19 2015-01-07 Koninklijke Philips N.V. Agents de contraste ultrasonores pour imagerie moleculaire
US7702378B2 (en) * 2005-11-17 2010-04-20 Breast-Med, Inc. Tissue marker for multimodality radiographic imaging
CN101015701A (zh) * 2007-03-12 2007-08-15 东南大学 在体反应式微气泡超声造影剂及其制备方法
GB0914171D0 (en) * 2009-08-13 2009-09-16 Smith & Nephew Ultrasound couplant
GB201223332D0 (en) * 2012-12-21 2013-02-06 Yeh James S Microparticle compositions
EP2774597A1 (fr) * 2013-03-06 2014-09-10 L'Oréal Composition changeant de couleur sous forme d'émulsion comprenant un homopolymère ou copolymère acrylique réticulé partiellement neutralisé
CN103432600B (zh) * 2013-08-26 2015-01-28 王春红 一种抗菌型医用超声耦合剂及其制备方法
CN103585645B (zh) * 2013-10-18 2015-09-23 浙江大学 一种基于3d打印的生物兼容性超声造影剂及其制备方法
US20150238410A1 (en) * 2014-02-27 2015-08-27 Mila Klevtsov Ultrasound anti stretch mark gel composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11318898A (ja) * 1998-05-14 1999-11-24 Pola Chem Ind Inc 超音波診断用ゲル組成物
JP2001097847A (ja) * 1999-09-29 2001-04-10 Pola Chem Ind Inc ゲル組成物の製造法
JP2011213646A (ja) * 2010-03-31 2011-10-27 Noevir Co Ltd ゲル組成物
JP2015224326A (ja) * 2014-05-29 2015-12-14 住友精化株式会社 超音波媒体用組成物

Also Published As

Publication number Publication date
CN109069129B (zh) 2021-10-26
JP2017153871A (ja) 2017-09-07
JP6130538B1 (ja) 2017-05-17
CN109069129A (zh) 2018-12-21

Similar Documents

Publication Publication Date Title
WO2018184516A1 (fr) Composition hydratante et son application dans la préparation d'un produit cosmétique hydratant
JP4767914B2 (ja) 皮膚をひきしめる効果のある化粧組成物
KR20180123036A (ko) 보습용 조성물 및 이의 용도
KR101633639B1 (ko) 자기회합 겔 특성을 이용한 세포막 유사 구조의 나노 겔타입의 에멀젼 및 그를 이용한 화장료 조성물
JP6516083B2 (ja) 経皮吸収基材
JP6130538B1 (ja) 超音波伝達効率向上組成物、超音波診断用ゲル組成物及び超音波撮影方法
KR20200116478A (ko) 기능성 다당 입자
TWI835729B (zh) 粉刺去除用組成物
EP2438902B1 (fr) Procédé de nettoyage de la peau
CN110520102B (zh) 皮肤清洁剂组合物
JP2018043971A (ja) 化粧料
JP6934767B2 (ja) 超音波伝達効率向上組成物、超音波診断用ゲル組成物及び超音波撮影方法
JP2017043588A (ja) 皮膚外用剤用キット
WO2018020903A1 (fr) Agent externe pour la peau
JP2016166133A (ja) パック化粧料
JP2002128636A (ja) 除去容易なパック化粧料
WO2022259901A1 (fr) Produit cosmétique de type hyaluronate pénétrant dans la peau
EP3796926A1 (fr) Peptides encapsulés dans de la lécithine et de l'alginate
FR3095345A1 (fr) Composition cosmetique comprenant une matrice polymerique
JP2024509008A (ja) 皮膚改善に有効な成分とダイヤモンドとがコーティングされたスピキュール製造方法及びこれを含むダイヤモンドスピキュール化粧料組成物
JP6820463B2 (ja) 皮膚外用剤および抗シワ剤
JP3126117B2 (ja) 超音波診断用ゲル組成物
JP2018016728A (ja) ゲル状組成物及びゲル状組成物の製造方法
JP6935684B2 (ja) 水性化粧料
JP2001316243A (ja) 油中水型エマルション形態の組成物およびその化粧的使用

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16892656

Country of ref document: EP

Kind code of ref document: A1

122 Ep: pct application non-entry in european phase

Ref document number: 16892656

Country of ref document: EP

Kind code of ref document: A1