WO2017143668A1 - Applications d'un dérivé d'acide myristique dans la préparation d'un promoteur de croissance animale - Google Patents

Applications d'un dérivé d'acide myristique dans la préparation d'un promoteur de croissance animale Download PDF

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Publication number
WO2017143668A1
WO2017143668A1 PCT/CN2016/081816 CN2016081816W WO2017143668A1 WO 2017143668 A1 WO2017143668 A1 WO 2017143668A1 CN 2016081816 W CN2016081816 W CN 2016081816W WO 2017143668 A1 WO2017143668 A1 WO 2017143668A1
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WO
WIPO (PCT)
Prior art keywords
myristic acid
animal
acid derivative
feed
growth
Prior art date
Application number
PCT/CN2016/081816
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English (en)
Chinese (zh)
Inventor
彭险峰
Original Assignee
广州英赛特生物技术有限公司
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Application filed by 广州英赛特生物技术有限公司 filed Critical 广州英赛特生物技术有限公司
Publication of WO2017143668A1 publication Critical patent/WO2017143668A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats

Definitions

  • the invention belongs to the field of animal feed additives, and particularly relates to the application of myristic acid derivatives in the preparation of animal growth promoters, and further to the application of alternative feed antibiotic animal growth promoters.
  • Synthetic antibacterial agents are chemical substances produced by chemical methods, which can inhibit and prevent the development and metabolism of other microorganisms. As a feed additive, there are also problems of drug residues and drug resistance, and side effects are large and even urinary system damage and teratogenic carcinogenesis .
  • the myristic acid derivative of the present invention has myristic acid salt and glycerin myristate, and the structure of the myristic acid salt is as shown in the formula (I):
  • R is selected from the group consisting of Na, K and Ca;
  • the present invention finds for the first time through experiments that the myristic acid derivative of the present invention is used as an additive in low-dose application in animal feed, and has a significant promoting effect on the growth performance of the cultured animal, which is manifested in the weight gain of the cultured animal. There is a significant improvement in the conversion rate of feed and feed.
  • the myristic acid derivative of the present invention has more plague-positive bacteria such as Clostridium perfringens, which is common to animals, compared to other medium- or long-chain fatty acid derivatives. Significant inhibition effect, reaching the current level of efficacy of commonly used feed antibiotics.
  • the myristic acid derivative can be used as a growth promoter for a feeding antibiotic animal to maintain a balance of beneficial bacteria in the intestinal tract and intestinal tract by inhibiting the growth of pathogenic bacteria in the gastrointestinal tract of an animal.
  • the tissue is protected from damage and promotes the digestion and absorption of nutrients in animal feed in the gastrointestinal tract.
  • the myristic acid derivative is combined with a feed carrier, diluent, antioxidant, anti-caking agent, vehicle, or a combination thereof to form a feed additive for growth promotion of the animal.
  • the feed additive is a tablet, a powder, a powder, a granule, an oral solution, a capsule, a premix, and the like.
  • the feed additive provided by the present invention is added to the animal's basal diet in a separate form.
  • the feed additive, the feed additive, the carrier or the diluent provided by the present invention are prepared into an additive premixed feed, concentrated feed, compound feed, concentrate supplement feed, etc. in a certain ratio for the animal. edible.
  • the animal growth promoter is used in the feed in an amount of from 10 to 3,000 ppm, preferably from 50 to 1,500 ppm, based on the dose of the myristic acid derivative.
  • the myristic acid derivative is used for animal growth, and the animal is mainly a farm animal such as a livestock, a poultry or an aquatic animal, and specifically includes chicken, turkey, guinea fowl, duck, goose, pigeon, donkey, and each growth stage.
  • Herbivorous or non-grass animals such as pigs, cattle, sheep, horses, rabbits, donkeys, dogs, cats, foxes, crickets or crickets or other artificially caught animals or pets, as well as fish of various stages of growth, Shrimp or crab.
  • the myristic acid derivative has been used as an energy material for 72% of the energy supply of animals in functional feeds of animals.
  • the blood lipids of farmed animals are high, but the growth of cultured animals caused by other fatty acid esters is slow or even high.
  • the health problems occurring in the above animals have not occurred in the dose range used in the present invention, and therefore have the characteristics of safety effectiveness required as an animal production promoter.
  • the myristic acid derivative provided by the invention can be used as a novel safe and effective animal growth promoter in the animal breeding industry, in particular, the application of the antibiotic anti-animal growth promoter can be used to overcome the feeding.
  • the myristic acid derivatives used in the following examples of the present invention are all provided by the research and development center of Guangzhou Insex Biotechnology Co., Ltd., and the sample purity is 99%; the virginiamycin preparation used is an imported premix, by the United States. Huibao Co., Ltd. is produced in Belgium.
  • Example 1 Inhibitory activity of different myristic acid derivatives against Clostridium perfringens.
  • the minimum inhibitory concentration (MIC) of virginiamycin and medium-long chain fatty acid derivatives against Clostridium perfringens was tested by tube double dilution method. The results are shown in Table 1. As can be seen from Table 1, all the test strains were sensitive to virginiamycin, and all the test myristic acid derivatives had similar inhibitory activity to the test strains as virginiamycin; The inhibitory activity of the long-chain fatty acid derivative against the test strain was observed to show that the myristic acid derivative had stronger antibacterial activity (Table 1).
  • Example 2 Application effect of myristic acid derivatives in weaned piglets.
  • Example 3 Effect of synergistic application of calcium myristate in weaned piglets.
  • Example 4 Application effect of calcium myristate in chicken feed.
  • 2200 pigeons 1 day old fast yellow broiler chickens were randomly divided into 11 test groups, each test group consisted of 4 parallel test groups, 50 in each parallel test group, and different concentrations of myristic acid were added to each group of feeds. Calcium or calcium citrate or calcium palmitate. During the test period, they were caged, free to eat and free to drink. The test period was 28 days. The results showed that calcium myristate showed a more significant improvement in weight gain and feed compensation compared to the same dose of calcium citrate or calcium palmitate, and showed a dose effect (Table 4). .
  • Example 5 The combined application effect of calcium myristate in meat ducks.
  • the test fish used was grass carp, which was carried out by the aquatic farm of the Ince Test Site in Guangzhou.
  • the healthy and lively, uniform-sized green carp species were used for formal culture trials after being kept in large cages for 4 weeks.
  • the experimental system was a floating small cage. Both the small cage and the holding cage are placed in a 3500 m 2 pond at the test site. The pond water depth is ⁇ 1.5 m, and the pond water is fully aerated bottom water.
  • 160 fishes that were hungry for 1 day were randomly divided into 4 groups, each group consisted of 4 replicates, and 10 fishes were placed in each replicate. After weighing, they were randomly placed in 16 cages and fed different test feeds. .
  • the test feed was prepared according to the formula of Table 5. Different test groups were added with different growth promoters in the base materials. The test was fed by artificial diet, and the feeding amount was adjusted once a week. The feeding levels (by initial weight) were identical and fed twice a day (7:30 and 15:00). The trial lasted for 8 weeks.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)

Abstract

La présente invention concerne des applications d'un dérivé d'acide myristique dans la préparation d'un promoteur de croissance animale. Le dérivé d'acide myristique comprend un sel d'acide myristique et un ester de glycéryle d'acide myristique. Le dérivé d'acide myristique possède des activités inhibitrices importantes par rapport aux bactéries infectieuses courantes des animaux, procure des effets majeurs en termes de régulation du taux de diarrhées chez les animaux et d'amélioration des résultats en matière d'élevage animal, et peut être appliqué chez des animaux d'élevage tels que bétail, les volailles et les produits aquatiques.
PCT/CN2016/081816 2016-02-23 2016-05-12 Applications d'un dérivé d'acide myristique dans la préparation d'un promoteur de croissance animale WO2017143668A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610100318.6A CN105746908B (zh) 2016-02-23 2016-02-23 肉豆蔻酸衍生物在制备动物生长促进剂中的应用
CN201610100318.6 2016-02-23

Publications (1)

Publication Number Publication Date
WO2017143668A1 true WO2017143668A1 (fr) 2017-08-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2016/081816 WO2017143668A1 (fr) 2016-02-23 2016-05-12 Applications d'un dérivé d'acide myristique dans la préparation d'un promoteur de croissance animale

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CN (1) CN105746908B (fr)
WO (1) WO2017143668A1 (fr)

Citations (5)

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Publication number Priority date Publication date Assignee Title
US6596766B1 (en) * 1999-03-04 2003-07-22 Suntory Limited Utilization of material containing docosapentaenoic acid
CN1684664A (zh) * 2002-09-30 2005-10-19 维克公司 可注射的促进生长及驱肠虫的组合物
CN103260425A (zh) * 2010-12-23 2013-08-21 希尔氏宠物营养品公司 用于体重减轻与保持的宠物食品组合物和方法
CN103313607A (zh) * 2010-12-23 2013-09-18 希尔氏宠物营养品公司 用于治疗关节炎和关节炎相关炎症的宠物食品组合物以及方法
CN104186958A (zh) * 2014-05-23 2014-12-10 广州英赛特生物技术有限公司 肉豆蔻酸铜作为饲料添加剂的应用

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FI103704B (fi) * 1996-07-19 1999-08-31 Kemira Chemicals Oy Mikrobinvastainen koostumus, sen valmistusmenetelmä ja sen käyttö
WO2001097799A1 (fr) * 2000-06-20 2001-12-27 Nutrition Sciences Acides gras a chaines moyennes utilisables comme agents antimicrobiens
CN100521964C (zh) * 2004-02-27 2009-08-05 日本水产株式会社 鳝鱼用饲料
KR100856456B1 (ko) * 2007-07-27 2008-09-04 주식회사 일신웰스 면역 증강용 사료 첨가제 및 이를 포함하는 가축 사료
EP2082739A1 (fr) * 2008-01-25 2009-07-29 PURAC Biochem BV Lactylates pour la prévention et le traitement d'infections dues à des bactéries gram positives chez les animaux
CN102429119A (zh) * 2011-11-08 2012-05-02 成都市龙泉驿区十陵禽业合作社 一种含中链脂肪酸的抑制大肠杆菌o157:h7的羊饲料添加剂
CA2855467A1 (fr) * 2013-07-02 2015-01-02 Milk Specialties Global Neutralisation partielle de melanges d'acides gras libres avec du potassium, compositions d'aliments pour betail les comportant, et leurs procedes de fabrication

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596766B1 (en) * 1999-03-04 2003-07-22 Suntory Limited Utilization of material containing docosapentaenoic acid
CN1684664A (zh) * 2002-09-30 2005-10-19 维克公司 可注射的促进生长及驱肠虫的组合物
CN103260425A (zh) * 2010-12-23 2013-08-21 希尔氏宠物营养品公司 用于体重减轻与保持的宠物食品组合物和方法
CN103313607A (zh) * 2010-12-23 2013-09-18 希尔氏宠物营养品公司 用于治疗关节炎和关节炎相关炎症的宠物食品组合物以及方法
CN104186958A (zh) * 2014-05-23 2014-12-10 广州英赛特生物技术有限公司 肉豆蔻酸铜作为饲料添加剂的应用

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CN105746908A (zh) 2016-07-13
CN105746908B (zh) 2018-08-28

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