WO2017142158A1 - Composition antivieillissement et de réduction des rides de la peau, contenant un extrait de mélange de plantes médicinales en tant que substance active - Google Patents

Composition antivieillissement et de réduction des rides de la peau, contenant un extrait de mélange de plantes médicinales en tant que substance active Download PDF

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WO2017142158A1
WO2017142158A1 PCT/KR2016/010842 KR2016010842W WO2017142158A1 WO 2017142158 A1 WO2017142158 A1 WO 2017142158A1 KR 2016010842 W KR2016010842 W KR 2016010842W WO 2017142158 A1 WO2017142158 A1 WO 2017142158A1
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Prior art keywords
skin
ginger
extract
turmeric
aging
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PCT/KR2016/010842
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English (en)
Korean (ko)
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김종열
차성원
남지호
채성욱
임아랑
최송이
김영화
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한국 한의학 연구원
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Publication of WO2017142158A1 publication Critical patent/WO2017142158A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a composition for improving skin aging and wrinkles, which contains a herb extract as an active ingredient, and specifically, a ginger mixed with a weight ratio of 1: 3 to 6: 6 to 3: 1, creation, turmeric and broiler mixture. It relates to a skin aging and wrinkle improvement composition containing the extract as an active ingredient.
  • the skin protects the organs of the body from stimulation of the external environment and plays an important role in maintaining homeostasis such as temperature control.
  • the skin is aged by various internal and external factors, and is classified into endogenous aging due to genetic causes and exogenous aging due to environmental causes.
  • photoaging means aging by ultraviolet (UV).
  • UV ultraviolet
  • ozone layer destruction due to environmental pollution has increased the amount of ultraviolet rays, and thus, research on photoaging has been focused (Wang SQ et al., 2010, Dermatol. Ther. 23 (1): 31-47).
  • cosmetic features such as roughness, loss of elasticity, wrinkles and irregular pigmentation are observed.
  • the main research field of photo-aging is about the change of skin wrinkles.
  • ginger Zingiber officinale
  • the raw materials of Chinese herbal medicines are used in various ways.
  • the harvested rhizome is called ginger, and the steamed or boiled ginger dried is called health ( ⁇ ), and the roasted and dried is called black river.
  • Ginger secretes digestive juices to promote appetite, promote gastrointestinal motility, aid in digestion and absorption, and is also used for asthma at the same time as it eliminates phlegm, lowers energy, stops vomiting, removes cold and boils (Clinical Traditional) Herbalogy, Younglimsa, 1997, 293-296; and above, Herbal Science, 1981, 203-204). It is also used for antipyretic drugs, blood circulation disorders, cold and cold. Aromatherapy ingredients increase blood circulation and body temperature, and take honey mixed with ginger juice to treat colds and coughs. On the other hand, health is used when metabolic function is lowered and is used as a treatment for cough, dizziness, cold hands and feet, low back pain, diarrhea and vomiting. It is also used for planting, boosting sheep and removing cold of five viscera.
  • Atractylodes lancea is a root stem in the genus (Compositae) and plant, which is distributed in North China, Shanxi, etc., and is irregularly bent cylindrical shape of 3 ⁇ 10cm long and 10 ⁇ 25mm in diameter, and the outer surface is made by dark ash.
  • pharmacological action is known to have a healthy, diuretic, sweating, sedative, hypoglycemic, tonic action. Creation is a perennial herb, which grows in mountains all over the country. In the fall, it is cut and washed in water to trim fine roots and to dry in the sun.
  • Curcuma longa also known as horseshoe turmeric, is cultivated in the sub-central part of Korea, and the roots are washed in water in autumn and boiled or steamed to dry.
  • the taste is spicy, bitter and very warm. Promotes circulation and blood circulation, eliminates blood, eases pain and smoothes menstruation.
  • biliary tract function liver detoxification function, analgesic action, uterine contraction action antibacterial action. It is used for amenorrhea, bleeding, and chest and stomach aches, swelling of arms, hepatitis, cholelithiasis, and bruising carbuncles.
  • broilers Cinnamomum cassia
  • product specifications also include relatively many types such as variometers, relations, plates, chains, and chains. It is tubular or rolled into stem shell, 5 ⁇ 50cm long, 1.5 ⁇ 5cm in diameter, and 0.1 ⁇ 0.5cm thick. The outer side is dark reddish brown and the inner side is reddish brown and smooth. It is easy to bend and its face is reddish brown with a thin layer of light brown color and slightly fibrous. It has a peculiar smell, tastes slightly sweet and very, later slightly mucus and astringent.
  • the noise person is weak in spleen and stomach, and the kidney is faithful, so the shape of the body is well-balanced up and down.
  • the woman is well-framed, dense, cute and appealing. Forehead comes out a little, eyes, nose, mouth is not big, and the eyes are young and regular ( ⁇ ⁇ ) can be called.
  • the skin is so soft and dense that there is little sweat, and a woman does not lose her hands even when working in winter.
  • Examples of known ginger, creation, turmeric and broiler mixed extract and skin wrinkle improvement or skin aging related technology cosmetic composition comprising a product dermis and ginger mixed extract having antioxidant and anti-aging effects in Korean Patent No. 1118765 And a method of manufacturing the same, a cosmetic composition for improving wrinkles is known from Korean Patent Publication No. 2008-0094457, and a cosmetic composition containing broiler extract is disclosed in Korean Patent Publication No. 2001-0055960. 0891986 discloses a herbal cosmetic composition containing a herbal extract and a herbal powder, but it is mentioned with respect to the cosmetic composition for skin wrinkle improvement and anti-aging containing the ginger, creation, turmeric and broiler mixed extract of the present invention as an active ingredient No bar
  • the present invention is derived from the above demands, ginger ( Zingiber officinale), Creation ( Atractylodes) lancea ), Curcuma Longa ) and Cinnamomum cassia ( Cinnamomum cassia ) relates to a composition for improving skin wrinkles and anti-aging containing the extract as an active ingredient, in particular ginger, creation, turmeric and broiler extract 1: 2.5 ⁇ 6.5: 2.5 ⁇ 6.5: 1
  • the mixed extract mixed in a weight ratio suppresses cellular damage by ultraviolet irradiation, significantly suppresses the expression of MMP-1, and in particular, confirms that there is an antiwrinkle effect on the noise person, thereby completing the present invention.
  • the present invention provides a cosmetic composition for skin wrinkle improvement and anti-aging containing ginger, creation, turmeric and broiler mixed extract as an active ingredient.
  • the present invention also provides a functional food composition for improving skin wrinkles and anti-aging containing ginger, creation, turmeric and broiler mixed extract as an active ingredient.
  • the present invention provides a pharmaceutical composition for preventing and treating skin wrinkles containing ginger, creation, turmeric and broiler mixed extract as an active ingredient.
  • the present invention relates to a composition for improving skin wrinkles and anti-aging containing ginger, creation, turmeric and broiler mixed extract as an active ingredient, in detail, the ginger, creation, turmeric and broiler extract 1: 2.5 ⁇ 6.5: 2.5 ⁇ 6.5 Mixed extracts mixed at a weight ratio of 1 to 1 inhibit cellular damage by UV irradiation and significantly inhibit the expression of MMP-1.
  • the blending ratio of ginger, crude, turmeric and broiler extracts is 1: 2.5 to 6.5: 2.5 to 6.5: 1 by weight, it is more effective to irradiate with ultraviolet rays than to mix with other blending ratios or to use ginger, crude, turmeric or broiler extracts alone. It suppresses cellular damage by and significantly suppresses the expression of MMP-1.
  • the active ingredient of the present invention is effective to improve the skin wrinkles to the noise person in the Sasang constitution classified in the oriental medicine can be usefully used as a cosmetic composition, health functional food composition and pharmaceutical composition of the noise person.
  • HaCaT cells human keratinocytes
  • mixing ratio mixing according to the weight ratio
  • of ginger, creation, turmeric and broiler mixed extract of the present invention 50 ⁇ g / ml and 100 ⁇ g / ml
  • UV Crosslinker, UltR5 Lum ultraviolet
  • Figure 2 is a result confirming the expression amount of MMP-1 by the mixing ratio (mixing according to the weight ratio) of the ginger, creation, turmeric and broiler mixed extract of the present invention.
  • 3 is a definition and diagram of the wrinkle parameters used in replica analysis.
  • Figure 4 is a result of the analysis of the R1 parameter of the replica wrinkle effect between the test group and the control group using a product containing ginger, the production, turmeric and broiler mixed extract in a weight ratio of 1: 6: 3: 1 .
  • (A) shows R1 values measured before use (0W), after 4 weeks of use (4W), after 8 weeks of use (8W) and after 12 weeks of use (12W). The change rate of R1 is shown based on the previous (0W).
  • * Means that there is a statistically significant difference compared to before using the product according to the present invention (week 0), ⁇ means that there is a statistically significant difference between the test group and the control group, * And ⁇ indicate that the p value is less than 0.05.
  • Figure 5 is a result of the analysis of the R4 parameter of the replica wrinkle effect between the test group and the control group using a product containing ginger, the production, turmeric and broiler mixed extract in a weight ratio of 1: 6: 3: 1 .
  • (A) shows R4 values measured before use (0W), after 4 weeks of use (4W), after 8 weeks of use (8W) and after 12 weeks of use (12W). The change rate of R4 is shown based on the previous (0W).
  • the present invention relates to a cosmetic composition for improving skin wrinkles and anti-aging containing ginger, extract, turmeric and broiler mixed extract as an active ingredient.
  • the ginger, creation, turmeric and broiler extract is preferably extracted using at least one solvent selected from water, C 1 ⁇ C 4 lower alcohol, propylene glycol, ethyl acetate, butylene glycol, glycerin, ether and chloroform, more Preferably hot water extraction is not limited to this.
  • the mixing ratio of the ginger, creation, turmeric and broiler extract is preferably 1: 2.5 to 6.5: 2.5 to 6.5: 1 weight ratio, more preferably 1: 2.5 to 3.5: 5.5 to 6.5: 1 or 1: 5.5 to 6.5 : 2.5 to 3.5: 1 by weight, most preferably 1: 5.5 to 6.5: 2.5 to 3.5: 1 by weight, but not limited thereto, and when mixed in the above 1: 2.5 to 6.5: 2.5 to 6.5: 1 weight ratio, The effect of improving wrinkles is superior to using alone or mixing in different weight ratios.
  • the cosmetic composition is characterized in that the noise is cited in the filamentous constitution, and whether or not the noise in the present invention is most preferably diagnosed by a medicinal doctor, the teacher is clinical character, body shape, physiology, pathology and mental psychology and According to the criteria classified as ideology, which is theorized by disease prevention, treatment and philosophy through the framework of four classifications (sun, lunar, literacy, noise) all over the universe, the noise person is short. He often walks in a poor and prone position, and his lower body is relatively developed, but overall he is dwarf, weak, and has a pretty face.
  • Kidneys and bladder function is good, but the stomach is weak because it does not digest food well.
  • the cosmetic composition is effective in preventing skin aging and improving skin wrinkles by inhibiting the expression of MMP-1.
  • the skin wrinkle improvement and anti-aging cosmetic composition is an external skin ointment, cream, supple cosmetics, nourishing cosmetics, packs, essences, hair tonic, shampoo, conditioner, hair conditioner, hair Treatment, Gel, Skin Lotion, Skin Softener, Skin Toner, Astringent, Lotion, Milk Lotion, Moisture Lotion, Nutrition Lotion, Massage Cream, Nutrition Cream, Moisture Cream, Hand Cream, Foundation, Nutrition Essence, Sunscreen, Soap, Cleansing It may have any one formulation selected from the group consisting of foam, cleansing lotion, cleansing cream, body lotion and body cleanser, but is not limited thereto.
  • the cosmetic composition consisting of each of these formulations may contain various bases and additives necessary for the formulation of the formulation and are suitable, and the type and amount of these components can be easily selected by those skilled in the art.
  • the carrier component is animal fiber, vegetable fiber, wax, paraffin, starch, tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide. And the like can be used.
  • the formulation of the cosmetic composition of the present invention is a powder or a spray
  • lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as the carrier component, and in particular, in the case of a spray, further chlorofluoro Propellants such as hydrocarbon, propane-butane or dimethyl ether.
  • a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene.
  • a carrier component such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene.
  • the formulation of the cosmetic composition of the present invention is a suspension
  • a liquid diluent such as water, ethanol or propylene glycol
  • suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Microcrystalline cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.
  • the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, acethionate, an imidazolinium derivative, a methyltaurate, or a sarcosinate.
  • Fatty acid amide ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
  • the cosmetic composition of the present invention may further contain an excipient including a fluorescent substance, a fungicide, a caustic agent, a moisturizer, a fragrance, a fragrance carrier, a protein, a solubilizer, a sugar derivative, a sunscreen agent, a vitamin, a plant extract, and the like.
  • an excipient including a fluorescent substance, a fungicide, a caustic agent, a moisturizer, a fragrance, a fragrance carrier, a protein, a solubilizer, a sugar derivative, a sunscreen agent, a vitamin, a plant extract, and the like.
  • the present invention relates to a functional food composition for skin wrinkle improvement and anti-aging containing ginger, creation, turmeric and broiler mixed extract as an active ingredient.
  • the mixing ratio of the ginger, creation, turmeric and broiler extract is preferably 1: 2.5 to 6.5: 2.5 to 6.5: 1 weight ratio, more preferably 1: 2.5 to 3.5: 5.5 to 6.5: 1 or 1: 5.5 to 6.5 It is a weight ratio of 1: 2.5 to 3.5: 1, and most preferably 1: 5.5 to 6.5: 2.5 to 3.5: 1, but it is not limited thereto, and it is characterized by being a noise cited among filamentous constitutions.
  • the health functional food composition of the present invention When used as a food additive, the health functional food composition may be added as it is or used with other foods or food ingredients, and may be appropriately used according to a conventional method. Mixed amounts of active ingredients may be suitably used depending on the purpose of use (prevention or improvement).
  • the nutraceutical composition of the present invention is added in an amount of 15 parts by weight or less, preferably 10 parts by weight or less with respect to the raw material.
  • the amount may be below the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount above the above range.
  • dietary supplement there is no particular limitation on the type of dietary supplement.
  • foods to which the health functional food composition may be added include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, dairy products, including ice cream, various soups, drinks, tea Drinks, alcoholic beverages, vitamin complexes, and the like, and include all health foods in the conventional sense.
  • the nutraceutical composition of the present invention may be prepared as a food, in particular a functional food.
  • Functional foods of the present invention include ingredients that are commonly added in food production, and include, for example, proteins, carbohydrates, fats, nutrients and seasonings.
  • natural carbohydrates or flavors may be included as additional ingredients in addition to the active ingredient.
  • the natural carbohydrates may be monosaccharides (e.g. glucose, fructose, etc.), disaccharides (e.g.
  • the flavourant may be a natural flavourant (eg, taumartin, stevia extract, etc.) and a synthetic flavourant (eg, saccharin, aspartame, etc.).
  • the carbonation agent etc. which are used for a drink can be contained further.
  • the ratio of the above-mentioned ingredients is not critical, it is generally selected from 0.01 to 0.1 parts by weight based on 100 parts by weight of the health functional food composition of the present invention.
  • the present invention relates to a pharmaceutical composition for preventing and treating skin wrinkles, which contains ginger, extract, turmeric and broiler mixed extract as active ingredients.
  • the mixing ratio of the ginger, creation, turmeric and broiler extract is preferably 1: 2.5 to 6.5: 2.5 to 6.5: 1 weight ratio, but is not limited thereto, and is characterized by noise citation in filamentous constitution.
  • the pharmaceutical composition of the present invention may include a pharmaceutically acceptable carrier in addition to the active ingredient, which is commonly used in the preparation of lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia rubber, Calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, methyl cellulose, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and minerals Oils and the like, but are not limited thereto.
  • a pharmaceutically acceptable carrier in addition to the active ingredient, which is commonly used in the preparation of lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia rubber, Calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, methyl cellulose, methylhydroxybenzoate, prop
  • the pharmaceutical composition of the present invention may further include a lubricant, a humectant, a sweetener, a flavoring agent, an emulsifier, a suspending agent, a preservative, and the like.
  • a lubricant e.g., talc, kaolin, kaolin, kaolin, kaolin, kaolin, kaolin, kaolin, kaolin, kaolin, a kaolin, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, sorbitol, mannitol, mannitol, mannitol, mannitol, mannitol, mannitol, mannitol, mannitol, mannitol, mann
  • Suitable dosages of the pharmaceutical compositions according to the present invention vary depending on factors such as the formulation method, mode of administration, age, weight, sex, morbidity, food, time of administration, route of administration, rate of excretion and response to response of the patient. Can be. On the other hand, the dosage of the pharmaceutical composition of the present invention is preferably 0.0001 to 100 mg / kg (body weight) per day.
  • the pharmaceutical composition of the present invention can be administered orally or parenterally, and in the case of parenteral administration, it can be administered topically to the skin, intravenous injection, subcutaneous injection, intramuscular injection, intraperitoneal injection, transdermal administration and the like.
  • the concentration of the active ingredient included in the pharmaceutical composition of the present invention can be determined in consideration of the purpose of treatment, the condition of the patient, the period of time, etc., and is not limited to a specific range of concentration.
  • compositions of the present invention may be prepared in unit dosage form by formulating with a pharmaceutically acceptable carrier or excipient according to methods which can be easily carried out by those skilled in the art. It can be prepared by incorporation into a dose container.
  • the formulation may be prepared in any one formulation selected from injections, creams, patches, sprays, ointments, warnings, lotions, linings, pastas and cataplasmas, and may further include a dispersant or stabilizer. Can be.
  • Herbal medicine was purchased from OmniHub, and each sample was stored in a herbal storage refrigerator maintaining a temperature of 5.5 ⁇ 0.3 °C and humidity of 55 ⁇ 5%.
  • Ginger, creation, turmeric and broiler extracts were extracted by refluxing twice with reflux for 3 hours by adding water corresponding to 10 times the total weight of each of ginger, creation, turmeric and broilers. The extract was prepared by removing the solvent.
  • HaCaT cells human keratinocyte line
  • FBS fetal bovine serum
  • PS penicillin-streptomycin
  • DMEM Dulbecco's Modified Eagle Medium
  • the evaluation is performed on the skin safety through visual evaluation, skin wrinkle parameter measurement, questionnaire evaluation by the subject and observation and questionnaire at each time before and after use of the product (week 0 and week 4, 8, 12). It was.
  • the study recruited noisy women between the ages of 30 and 65 and recruited 22 noisy female subjects who met the subject selection criteria and did not meet the exclusion criteria. Their age ranged from 35 to 54 years (mean age: 45.2). ⁇ 5.2 years old).
  • Skin wrinkles are tested by dermapro dermatological research institutes who have started to produce wrinkles or who have already participated in this study. A participation agreement was written and the participants participated in the test.
  • BMI measurement Inbody 330, Biospace, Korea
  • body circumference measurement Inbody 330, Biospace, Korea
  • photography and Sasang Constitution Diagnosis Questionnaire Evaluation were conducted to determine the noise factor.
  • the noise factor was selected using (SCAT, Sasang Constitutional Analysis Tool).
  • the constitution was diagnosed through SCAT in the first filtered subjects, and the constitution factor, which is the noise according to the present invention, was selected.
  • the highest constitution value (max (TE, SE, SY)) and second highest constitution value (median (TE) SE, SY)) were selected in order of big difference, and 22 people (including one dropout) who were judged as noise noise were selected.
  • test site there are any abnormalities on the test site such as spots, acne, erythema, and capillary dilatation
  • Subjects should not mix with functional cosmetics or medicines other than the test product.
  • the basic cosmetics used outside the test product are only skins and lotions without functional ingredients. Sun cream products should be used when going out. At the time of visit (measurement), the visit was made without color makeup.
  • the number of subjects was tested by selecting 20 or more subjects according to guidelines for evaluating the effectiveness of functional cosmetics (2003, 2005), and guidelines for test methods for cosmetic labeling and advertisement (2013).
  • Skin wrinkles were evaluated by analyzing skin replica images using Visioline® VL650 (C + K, Germany) at each time point.
  • the intensity of transmitted light varies depending on the thickness of the replica according to the shape of the skin.
  • R1 is the difference between the highest peak and the lowest valley of the wrinkle profile, and R2 equals five wrinkle profiles to get five R1 values, which is the largest of them.
  • R3 is an arithmetic mean of five consecutive R1 values by equalizing five wrinkle profiles, resulting in the removal of artifacts compared to R1 and R2.
  • R1, R2, and R3 can be understood as values representing the depth of wrinkles.
  • R4 is the average depth of skin wrinkles by drawing the horizontal line at the top of the profile and integrating the area with the profile divided by the length of the midline of the profile.
  • R5 is the mean roughness of the skin divided by the length of the midline of the profile by integrating the area between the midline of the profile and the profile (FIG. 3).
  • facial left and right sides were photographed using a facial skin imaging device (VISIA® CR, Canfield, USA).
  • VISIA® CR facial skin imaging device
  • the questionnaire about the efficacy of the product was conducted by the subject at the 4, 8, and 12 weeks of product use. The subjects were assessed at the 5-point scale (1, not at all; 2, not at all; 3. no difference; 5. Very much). In addition, the questionnaire on product usability was assessed on a five-level scale (1, not at all; 2, not good; 3, moderate; 4, good; 5, very good) at the time of evaluation 12 weeks after product use. The positive responses (4, good; 5, very good) written by the subjects were analyzed.
  • ginger, creation, turmeric and broiler extracts were prepared, and the weight ratio of ginger: creation: turmeric: chicken was 1: 1: 1: 1, 1: 2: 2: 1,1
  • the mixed extracts were prepared by mixing 1: 3: 3: 1, 1: 3: 6: 1, 1: 6: 3: 1.
  • the cell viability and MMP-1 expression levels were analyzed using the mixed extract prepared in Example 1, and the most effective mixed extract was selected to analyze the wrinkle improvement effect on 21 people with noise.
  • Example 1 The weight ratio of 1: 1: 1: 1: 1, 1: 2: 2: 1, 1: 3: 3: 1, 1: 3: 6: 1 and 1: 6: 3: 1 prepared in Example 1
  • the mixed ginger, extract, turmeric, and broiler mixed extracts were treated with HaCaT cells (human keratinocyte line) for 24 hours, irradiated with ultraviolet (UV Crosslinker, Ultra Lum) for 30 minutes, and then subjected to MTS assay.
  • HaCaT cells human keratinocyte line
  • UV Crosslinker, Ultra Lum ultraviolet
  • the cell survival rate was different according to the mixing ratio of the ginger, the production, turmeric and broiler mixture extract, the cell survival was reduced to 51.09% by UV irradiation, the mixing ratio 1: 6: 3:
  • the cell survival rate was 74.85% when treated with 50 ⁇ g / ml of ginger, production, turmeric and broiler mixed extract of 1, and the cell survival rate was 80.99% when treated with 100 ⁇ g / ml.
  • the cell survival rate was 93.93% when treated with ginger, production, turmeric and broiler extracts 3: 3: 1, and the cell viability was 94.11 when treated with 100 ⁇ g / ml. Appeared in%.
  • MMPs Collagen degrading enzymes
  • Example 3 the effect of improving wrinkles of a mixture of ginger, creation, turmeric and broiler extracts, which are active ingredients of the present invention, was analyzed by analyzing the change in the expression level of collagen degrading enzymes (MMPs; matrix metalloproteinases), which have a significant effect on collagen reduction Check whether there is.
  • MMPs collagen degrading enzymes
  • the expression level of MMP-1 was very low in the cells not irradiated with ultraviolet rays, it was confirmed that the expression of MMP-1 was significantly increased by ultraviolet irradiation.
  • the expression level (ng / ml) of MMP-1 was significantly reduced compared to the case of ultraviolet irradiation.
  • ginger, extract, turmeric and broiler extracts are mixed at a weight ratio of 1: 6: 3: 1, by confirming that the expression level of MMP-1 is very low, it is determined that the active ingredient of the present invention is effective in improving wrinkles. It was.
  • Example 4 based on the results of Examples 2 and 3, to prepare a test product containing a mixture of ginger, creation, turmeric and broiler mixed extract in a weight ratio of 1: 6: 3: 1, the most effective We conducted a clinical trial that applied it to 21 noisy patients.
  • Group 21 is a test group containing ginger, extract, turmeric and broiler mixed extract of 1: 6: 3: 1, which is an active ingredient of the present invention
  • group B is a control group that does not contain the active ingredient of the present invention.
  • Tables 2 to 4 below disclose information, skin types and skin conditions of test groups (A) and control groups (B) participating in clinical trials.
  • the skin of the test group and the control group was visually analyzed using RM ANOVA before, after 4 weeks, after 8 weeks, and after 12 weeks of application.
  • p value is less than 0.05, which means that there is a significant difference between the test group and the control group.

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Abstract

La présente invention concerne une composition de réduction des rides et antivieillissement de la peau, contenant, en tant que substance active, un mélange d'extraits de gingembre, Atractylodes lancea, Curcuma longa et Cinnamomum cassia et, spécifiquement, un mélange d'extraits, obtenu par mélange des extraits de gingembre, Atractylodes lancea, Curcuma longa et Cinnamomum cassia dans un rapport de 1 : 2,5-6,5 : 2,5-6,5 : 1 en poids, inhibe les dommages cellulaires causés par le rayonnement UV et inhibe remarquablement l'expression de MMP-1. La composition de la présente invention peut être utilisée en tant que produits cosmétiques, compléments alimentaires et compositions pharmaceutiques et, en particulier, présente un effet remarquable de réduction des rides cutanées sur le type soeum parmi des constitutions sasang classifiées en médecine coréenne traditionnelle.
PCT/KR2016/010842 2016-02-16 2016-09-28 Composition antivieillissement et de réduction des rides de la peau, contenant un extrait de mélange de plantes médicinales en tant que substance active WO2017142158A1 (fr)

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KR1020160017794A KR101738339B1 (ko) 2016-02-16 2016-02-16 한약재 혼합 추출물을 유효성분으로 함유하는 피부 노화 및 주름 개선용 조성물
KR10-2016-0017794 2016-02-16

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110326627A (zh) * 2018-09-17 2019-10-15 中国医学科学院药用植物研究所 空气清新喷雾剂

Families Citing this family (1)

* Cited by examiner, † Cited by third party
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KR102013576B1 (ko) 2017-12-12 2019-08-23 한국콜마주식회사 강황 및 생강 혼합 추출물을 포함하는 피부 개선용 화장료 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950028734A (ko) * 1994-04-02 1995-11-22 조영훈 체질판별 및 건강증진용 칼라 조성물
KR20040016471A (ko) * 2002-08-17 2004-02-25 주식회사 태평양 한방 피부미용 식품조성물
KR20100042181A (ko) * 2008-10-15 2010-04-23 (주)더페이스샵코리아 대황 및 황련 추출물을 함유하는 자외선에 대한 피부보호용화장료 조성물
KR20130023850A (ko) * 2011-08-30 2013-03-08 인타글리오주식회사 녹차 추출물, 울금 추출물, 후박추출물 및 독활 추출물의 나노캡슐을 포함하는 화장료 조성물 및 그 제조방법
KR20150014022A (ko) * 2013-07-26 2015-02-06 주식회사 알파크립텍 아트락틸레노라이드 ⅲ를 유효성분으로 함유하는 피부주름 개선용 화장료 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950028734A (ko) * 1994-04-02 1995-11-22 조영훈 체질판별 및 건강증진용 칼라 조성물
KR20040016471A (ko) * 2002-08-17 2004-02-25 주식회사 태평양 한방 피부미용 식품조성물
KR20100042181A (ko) * 2008-10-15 2010-04-23 (주)더페이스샵코리아 대황 및 황련 추출물을 함유하는 자외선에 대한 피부보호용화장료 조성물
KR20130023850A (ko) * 2011-08-30 2013-03-08 인타글리오주식회사 녹차 추출물, 울금 추출물, 후박추출물 및 독활 추출물의 나노캡슐을 포함하는 화장료 조성물 및 그 제조방법
KR20150014022A (ko) * 2013-07-26 2015-02-06 주식회사 알파크립텍 아트락틸레노라이드 ⅲ를 유효성분으로 함유하는 피부주름 개선용 화장료 조성물

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110326627A (zh) * 2018-09-17 2019-10-15 中国医学科学院药用植物研究所 空气清新喷雾剂

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