WO2017014340A1 - Composition contenant des extraits de stephanandra incisa (thunb.) zabel ayant une efficacité anti-vieillissement, et utilisation la contenant comme principe actif - Google Patents

Composition contenant des extraits de stephanandra incisa (thunb.) zabel ayant une efficacité anti-vieillissement, et utilisation la contenant comme principe actif Download PDF

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WO2017014340A1
WO2017014340A1 PCT/KR2015/007654 KR2015007654W WO2017014340A1 WO 2017014340 A1 WO2017014340 A1 WO 2017014340A1 KR 2015007654 W KR2015007654 W KR 2015007654W WO 2017014340 A1 WO2017014340 A1 WO 2017014340A1
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extract
noodle
active ingredient
aging
composition
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PCT/KR2015/007654
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English (en)
Korean (ko)
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정현정
박성하
김유아
박병준
정태화
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한국콜마주식회사
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Definitions

  • the present invention relates to a composition containing an extract of Noodles having an anti-aging effect and a use thereof as an active ingredient, and more particularly, to inhibiting NO production after treating lipopolysaccharide (LPS) that induces an inflammatory response.
  • LPS lipopolysaccharide
  • COX-2 cyclooxygenase-2
  • iNOS nitric oxide synthase
  • the aging process can be largely divided into intrinsic aging and photoaging. As the age increases, active oxygen species can be activated. If this condition is exacerbated, the function of cells and tissues is impaired, leading to aging. At this time, as a cause of inflammation, reactive oxygen species are produced by various biochemical stimuli in the body due to excessive stress, etc., various biochemical phenomena are involved as a cause of inflammation.
  • Inflammation is a local physiological response that protects the living body from factors that may or may not be harmful to tissue.
  • Enzymes such as elastase, hyaluronidase and lipoxygenase are well known for protein and lipolytic enzymes produced during inflammation. Their actions sometimes cause detrimental damage to adjacent tissue cells and noncellular components.
  • proteolytic enzymes caused by excessive inflammation damage cells and connective tissues, and the damage of connective tissues reduces skin elasticity and causes wrinkles, as well as rapid skin aging. Therefore, by inhibiting the following proteins and lipolytic enzymes produced by excessive inflammation, it is possible to protect the damaged cells thereby inhibiting skin aging.
  • ROS reactive oxygen species
  • NO nitric oxide
  • Cox-2 cyclooxygenase-2
  • nitric oxide is produced by nitric oxide synthas (NOS), and enzymes involved in nitric oxide synthas (NOS) are classified into two types.
  • NOS nitric oxide synthases
  • nNOS inducible nitric oxide synthases
  • eNOS endothelial nitric oxide synthase
  • LPS lipopolysaccharide -induced cytokines.
  • COX-2 which forms the central axis of the inflammatory mediator, is involved in the production of PGs (Prostaglandin).
  • COX-2 When COX-2 is activated, PGE 2 (Prostaglandin E 2 ) is produced. NF- ⁇ B is activated and moves to the nucleus to induce an inflammatory response and is involved in the expression of various genes such as iNOS and COX-2.
  • PGE 2 Prostaglandin E 2
  • NF- ⁇ B is activated and moves to the nucleus to induce an inflammatory response and is involved in the expression of various genes such as iNOS and COX-2.
  • Noodle Tree ( Stephanandra incisa ( Thunb.) Zabel is a deciduous broad-leaved shrub of the family Rosaceae, native to Korea, and distributed in Korea, northeastern China, Taiwan (Taiwan), and Japan. Inhabits forests or edges with mixed conifers and hardwoods, sunny slopes and roadsides. Likes the sunny side but grows well in the shade and is strong against cold. Its height is 1 ⁇ 2m, many branches come out, and it is limp on the ground like a long vine, so the whole is like a round bush. Twigs are round and have hairs or cilia.
  • the leaves are 2 ⁇ 5cm long, triangular broad egg-shaped, pointed at the end, sharp and deep teeth at the edges, and may be divided into several branches. Reddish petiole has fine hairs. Flowers bloom from May to June with yellowish white flowers with a diameter of 4-5mm and run in cones at the end of the branches. Calyx leaves are sharp at the end, 5 petals, 10 stamens, shorter than petals. Fruits are round or egg-shaped, with a lot of fine hairs and ripen in August-September.
  • Korean Patent No. 523443 discloses a composition for the prevention and / or treatment of obesity, based on one or more extracts selected from the group consisting of alder, cypress, and noodle from the native plant group, and Republic of Korea Patent Publication No. 2011-0068923 The issue reports a Noodle Leaf Extract as an active ingredient of an antihistamine composition.
  • US Patent Publication No. 2009-68291 discloses a Noodle Extract as a plant extract comprising an in vitro protease inhibitor and reports its activity.
  • the present inventors have investigated the physiological activity of domestic native plants, and the extract of N. japonica ( Stephanandra incisa ( Thunb.) Zabel) was treated with lipopolysaccharide (LPS), which induces an inflammatory response, and inhibited NO production.
  • LPS lipopolysaccharide
  • COX-2 Xenase-2
  • iNOS nitric oxide synthase
  • Another object of the present invention to provide a skin anti-aging cosmetic composition containing the noodle extract as an active ingredient.
  • Still another object of the present invention is to provide an external preparation composition for skin containing the noodle extract as an active ingredient.
  • the present invention has an anti-aging effect by the immune activity of the production inhibitory to inflammatory pathogens ( Stephanandra) incisa (Thunb.) Zabel) Provides a composition containing an extract.
  • Noodle extract extracts inhibited NO production and inhibited the production of cyclooxygenase-2 (COX-2) and nitric oxide synthase (iNOS). Since it has an anti-aging or skin useful effect.
  • LPS lipopolysaccharide
  • COX-2 cyclooxygenase-2
  • iNOS nitric oxide synthase
  • the noodle extract is extracted from any one or two or more mixed sites selected from the group consisting of flowers, leaves, stems, fruits, seeds, roots and starch extracts of the Noodle plant, preferably water, hexane, methanol, It is extracted by an extraction solvent alone or in a mixture thereof selected from the group consisting of ethanol and butylene glycol.
  • the present invention provides a skin anti-aging cosmetic composition containing more than 0.001% by weight of the noodle extract as an active ingredient.
  • the present invention also provides a topical skin composition containing more than 0.001% by weight of noodle extract as an active ingredient.
  • Noodle extract of the present invention has a production inhibitory activity against inflammatory pathogens that increase in production as aging progress, specifically after the LPS treatment to induce an inflammatory response, NO production inhibition by the immune response, cyclooxygenase- Noodle tree effective for anti-inflammatory and anti-aging applications by confirming its excellent stability due to its anti-aging effect showing inhibitory activity against 2 (COX-2) and nitric oxide synthase (iNOS) expression and no toxicity and irritation to skin
  • COX-2 inhibitory activity against 2
  • iNOS nitric oxide synthase
  • the present invention can provide a skin anti-aging cosmetic composition and an external composition for skin by containing the extract of the tree as an active ingredient.
  • Figure 3 is a result showing the inhibitory effect on the expression of COX-2 and iNOS in LPS-activated mouse macrophages (Raw264.7) according to the extract of the Noodle Tree of the present invention.
  • the present invention has an anti-aging effect by the immune activity of the production inhibitory to inflammatory pathogens ( Stephanandra) incisa (Thunb.) Zabel) Provides a composition containing an extract.
  • the noodle extract of the present invention may include all the noodle parts, for example, any one selected from the group consisting of flowers, leaves, stems, fruits, seeds, roots and starch extracts of the noodle tree plant or It can be extracted from two or more mixed sites. More preferably, in the embodiment of the present invention, the extract extracted from the mixed form of the leaves and stems of the noodle tree implements more excellent immunological activity against the inflammatory invention factor, but is not limited thereto.
  • each extract may be extracted using an extraction solvent of a single or mixed form selected from the group consisting of water, hexane, methanol, ethanol and butylene glycol, preferably methanol extract In the case of excellent activity.
  • the extraction solvent of alcohols including methanol and alcohol may be used without particular limitation on the purity, but preferably 80 to 95% methanol and 70 to 80% ethanol.
  • the noodle extract of the present invention is heated to extract hot water by heating at 45 ⁇ 120 °C for 30 minutes to 24 hours using the above extraction solvent, or in a method of extracting shaking by immersion at 5 ⁇ 40 °C for 30 minutes to 15 days It can be prepared by at least one extraction method selected, it is possible to improve the yield of the extract according to the extraction solvent and the extraction method.
  • the amount of the extraction solvent is not particularly limited, but when used in excess of the plant material, the extract cannot be extracted sufficiently, it takes a lot of time and money to remove the extraction solvent and obtain a dry extract after extraction. Therefore, in the case of hot water extraction, it is preferable to include a sufficient amount of plant material, and to extract it in a heated state in order to increase the extraction efficiency. If the temperature is too low, it is difficult to fully utilize the benefits of warming and must be extracted for a long time. Higher levels may lead to degradation of useful substances.
  • the powdered sample is immersed in a sufficient extraction solvent for a sufficient time, preferably for about 3 days to ensure that the effective ingredient is extracted sufficiently, if the extraction is not sufficient
  • the extraction volume may be increased by an iterative process or by increasing the extraction time.
  • Noodle extract extracted from each of the above extraction solvents is not useful for skin application because no cytotoxicity was observed under the concentration condition of 100 ⁇ g / ml [ FIG. 1 ].
  • each noodle extract 100 ⁇ g / ml compared to the control group treated with LPS It is possible to confirm the NO production inhibitory effect at a level of 30 to 40% at the concentration [ FIG. 2 ].
  • the noodle extract of the present invention extracts COX-2 and iNOS inhibitory effect in a concentration-dependent manner. Indicates. In particular, as confirmed in Figure 3 , it can be confirmed that the result of the iNOS expression is suppressed at a concentration of 100 ⁇ g / ml.
  • the Noodle extract of the present invention has an effect of inhibiting NO production and COX-2, iNOS expression after LPS treatment to induce an inflammatory response, and toxic and irritating to the skin at the concentration of 100 ⁇ g / ml or less Since it is excellent in terms of stability, it can be contained as an active ingredient of a skin anti-aging cosmetic composition or a topical skin composition.
  • the present invention provides a skin anti-aging cosmetic composition containing the noodle extract as an active ingredient.
  • the present invention provides an external skin composition having an anti-inflammatory and anti-aging effect containing the noodle extract as an active ingredient.
  • the external skin composition is a cream, gel, patch, spray, ointment, warning, It may be applied to lotion, liniments, pasta or cataplasma formulations.
  • noodle extract is preferably contained as 0.001% by weight or more as an active ingredient, the content is selected as the minimum content to implement the production inhibitory activity against the inflammatory disease.
  • the effective content may be increased in consideration of stability and immune activity of noodle extract, but is preferably contained within 30% by weight in consideration of discoloration and deodorization when applying skin.
  • Noodle Tree ( Stephanandra incisa (Thunb.) Zabel)
  • a mixture of leaf, stem extract and water in a 1:20 weight ratio was extracted with hot water, filtered through a 380 mesh, and then re-filtered with a 0.45 ⁇ m membrane filter (Supor®-450, 60173, PALL Life Sciences). Filtered. Thereafter, the filtrate was concentrated under reduced pressure at 40 ° C. in a distillation apparatus equipped with a cooling condenser and evaporated under reduced pressure to prepare noodle leaves and stem extracts 5.8 g.
  • Noodle Tree ( Stephanandra incisa (Thunb.) Zabel) Leaves, stem extract and hexane was mixed in a 1:20 weight ratio at room temperature immersion for 3 days, the process was extracted three times, and then filtered through a 380 mesh 0.45 ⁇ m membrane filter (Supor® -450, 60173, PALL Life Sciences). Thereafter, the filtrate was concentrated under reduced pressure at 40 ° C. in a distillation apparatus equipped with a cooling condenser and evaporated under reduced pressure to prepare 6.4 g of noodle extract.
  • Noodles Stephanandra incisa (Thunb.) Zabel
  • Leaves, stem extracts and methanol were mixed in a 1:20 weight ratio at room temperature for 3 days, and the process was repeated three times, followed by extraction with a 380 mesh to filter 0.45 ⁇ m membrane filter (Supor® -450, 60173, PALL Life Sciences). Thereafter, the filtrate was concentrated under reduced pressure at 40 ° C. in a distillation apparatus equipped with a cooling condenser and evaporated under reduced pressure to prepare ethanol methanol extract 6.8 g.
  • Noodle Tree ( Stephanandra incisa (Thunb.) Zabel) Leaves, stem extracts and ethanol were mixed at 1:20 weight ratio to immerse at room temperature for 3 days, extracted three times, and then filtered through a 380 mesh 0.45 ⁇ m membrane filter (Supor®). -450, 60173, PALL Life Sciences). Thereafter, the filtrate was concentrated under reduced pressure at 40 ° C. in a distillation apparatus equipped with a cooling condenser and evaporated under reduced pressure to prepare 5.1 g of noodle ethanol extract.
  • Noodle Tree ( Stephanandra incisa (Thunb.) Zabel) leaves, stem extract ingredients and butylene glycol were mixed in a 1:20 weight ratio, immersed at room temperature for 3 days, the process was extracted three times, and then filtered through a 380 mesh to 0.45 ⁇ m membrane filter Refiltration was performed to prepare a noodle butylene glycol extract.
  • Noodle Tree ( Stephanandra incisa (Thunb.) Zabel) Except for using the fruit component, was carried out in the same manner as in Example 3, to prepare a 5.7 g of Noodle fruit methanol extract.
  • Noodle Tree ( Stephanandra incisa (Thunb.) Zabel) Except for using the root component, it was carried out in the same manner as in Example 3, to prepare 4.2g of Noodle root methanol extract.
  • Noodle Tree ( Stephanandra incisa (Thunb.) Zabel) Except for using the starch component, it was carried out in the same manner as in Example 3, to prepare 6.3g of methanol extract Noodle outpost.
  • the noodle methanol extract prepared in Example 3 above was sampled in a 96-well plate at a concentration of 100, 75, 50, 25, 10, 5, 1, 0.5, 0.1 ⁇ g / ml in a 37 ° C., CO 2 incubator. Incubated for 24 hours.
  • mice macrophage Raw264.7 cells were injected into 96-well plates at a concentration of 5 ⁇ 10 cells / ml and 37 ⁇ l. C, incubated for 24 hours in a CO 2 incubator. In this case, DMEM / high glucose (Dulbeco's Modified Eagle Medium, Hyclone) containing 10% bovine serum and 1% antibiotic was used.
  • DMEM / high glucose Dulbeco's Modified Eagle Medium, Hyclone
  • Methanol extract prepared above was sampled in a 96-well plate at a concentration of 100, 50 or 25 ⁇ g / ml, and 90 ⁇ l of DMEM (Dulbecco's modified Eagle's medium) and 10 ⁇ l of sample at 37 ° C. in a CO 2 incubator. After the reaction, LPS (Lipopolysaccharide) was treated with 1 ⁇ g / ml and incubated for 24 hours at 37 °C, CO 2 incubator.
  • the amount of NO (Nitrite Oxide) produced was measured in the form of NO2 present in the cell culture solution using a Greries reagent (NED solution, sulfanilamide solution).
  • NED solution, sulfanilamide solution Cell culture supernatant 50 ⁇ l and Greece reagent (NED solution, sulfanilamide solution), respectively after the treatment by 50 ⁇ l reacted by blocking the light for 10 minutes at room temperature, and measuring the 540nm / 655nm absorbance, to the results in Table 1 and Table 2 is described.
  • RAW 264.7 cells (5 ⁇ 10 5 cells / ml) were pre-incubated for 18 hours, and the test substance (100, 50, 25 ⁇ g / ml of methanol extract of Example 3) and LPS (1 ⁇ g / ml) simultaneously Treated and incubated for 24 hours.
  • Formulation examples for the flexible cosmetics in the cosmetics containing the methanol extract of the noodle tree prepared in Example 3 as an active ingredient is shown in Table 3 below.
  • sodium hyaluronate was prepared as a 1% solution by dispersing at 3000 rpm propeller mixer in purified water.
  • the raw materials 1 to 8 were homogenized at 500 rpm in a propeller mixer in a water phase dissolving tank, warmed at 75 ° C. to completely dissolve, and then cooled to room temperature.
  • the raw materials 9-11 were completely melt
  • noodle methanol extract prepared in Example 3 was added and sufficiently stirred and mixed to prepare a flexible cosmetic water.
  • Formulation example for the nutrient cosmetic water in the cosmetics containing the methanol extract of noodle tree prepared in Example 3 as an active ingredient is shown in Table 4 .
  • Carbomer was prepared in 2% solution by dispersing with propeller mixer 4000rpm in purified water.
  • the raw materials 1-6 were thrown into the water melting tank, and it stirred at 2000 rpm and disperse
  • the raw materials 7-13 were put into the oil phase dissolution tank, and it melt
  • the oil phase dissolved in the aqueous phase dissolution tank was introduced and emulsified (3000 rpm / 5 minutes), followed by cooling to room temperature. Into this, noodle methanol extract prepared in Example 3 was added and sufficiently stirred and mixed to prepare nutritious longevity.
  • Formulation example for the essence of the cosmetics containing the methanol extract of noodle tree prepared in Example 3 as an active ingredient is shown in Table 5 below.
  • Sodium hyaluronate and hydroxyethyl cellulose were each dispersed in purified water at 2000 rpm with a propeller mixer to prepare a 1% solution.
  • Carbomer was prepared in 2% solution by dispersing with propeller mixer 4000rpm in purified water.
  • the raw materials 1-12 were thrown into the aqueous phase dissolution tank, and it stirred at 2000 rpm and disperse
  • the warm water phase was cooled to room temperature. After completely dissolving the raw materials 13-15 in another dissolution tank, the solution was added to the aqueous phase dissolution tank and stirred and mixed.
  • Example 3 Here, the noodle methanol extract prepared in Example 3 was added thereto, followed by sufficiently stirring and mixing to prepare an essence.
  • Formulation example for the nourishing cream in the cosmetic composition containing the methanol extract of noodle tree prepared in Example 3 as an active ingredient is shown in Table 6 .
  • the raw materials 1-8 were thrown into the water melting tank, it stirred at 2000 rpm, and it disperse
  • Raw materials 9-16 were thrown into the oil phase dissolution tank, and it heated and melt
  • the oil phase dissolved in the aqueous phase bath was added to emulsify (3000 rpm / 10 minutes), and then cooled to room temperature. Into this, noodle methanol extract prepared in Example 3 was added and sufficiently stirred and mixed to prepare a nourishing cream.
  • the present invention through the study on the physiological activity of domestic native plants ( Stephanandra) By incisa ( Thunb.) Zabel extract confirmed the anti-aging effect by the immunosuppressive activity of the production inhibitory to inflammatory onset factors, to provide a composition containing the Noodle extract effective for anti-inflammatory and anti-aging applications.
  • the present invention provides a skin anti-aging cosmetic composition and a topical skin composition containing the extract as an active ingredient by checking the stability of the noodle extract does not have toxicity and irritation to the skin.

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Abstract

La présente invention concerne une composition contenant des extraits de Stephanandra incisa (Thunb.) Zabel ayant une efficacité anti-vieillissement, et une utilisation la contenant comme principe actif. La présente invention fournit des extraits de Stephanandra incisa (Thunb.) Zabel ayant un effet anti-vieillissement au moyen de l'activité immunologique en raison de la répression de production de NO et de l'inhibition de production de cyclo-oxygénase-2 (COX-2) et de synthase d'oxyde nitrique (iNOS), après traitement de lipopolysaccharides (LPS) qui induisent une réponse inflammatoire. En outre, les extraits ont une excellente stabilité en raison de l'absence de toxicité et d'irritation cutanée, ainsi que l'effet anti-vieillissement en raison de l'activité immunologique et, par conséquent, la présente invention peut fournir une composition cutanée cosmétique anti-vieillissement et une composition cutanée pour application externe la contenant comme principe actif.
PCT/KR2015/007654 2015-07-22 2015-07-23 Composition contenant des extraits de stephanandra incisa (thunb.) zabel ayant une efficacité anti-vieillissement, et utilisation la contenant comme principe actif WO2017014340A1 (fr)

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KR1020150103904A KR101790624B1 (ko) 2015-07-22 2015-07-22 항염증 효능을 가지는 국수나무 추출물을 함유하는 조성물 및 그를 유효성분으로 함유한 용도
KR10-2015-0103904 2015-07-22

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KR20230027419A (ko) * 2021-08-19 2023-02-28 계명대학교 산학협력단 국수나무 추출물을 유효성분으로 포함하는 모발성장 촉진 또는 탈모예방용 조성물

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KR20130039026A (ko) * 2011-10-11 2013-04-19 (주)아모레퍼시픽 구기자와 솔잎의 혼합 추출물을 유효성분으로 함유하는 레티노익산 수용체의 활성화를 통한 항노화용 조성물

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US20110217753A1 (en) * 2001-03-02 2011-09-08 Biopharmacopae Design International Inc. Inhibitors of extracellular proteases
KR100523443B1 (ko) * 2002-08-19 2005-10-25 주식회사 엠디바이오알파 항비만 및 항당뇨효과를 보이는 자생식물 추출물
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KR20130039026A (ko) * 2011-10-11 2013-04-19 (주)아모레퍼시픽 구기자와 솔잎의 혼합 추출물을 유효성분으로 함유하는 레티노익산 수용체의 활성화를 통한 항노화용 조성물

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230027419A (ko) * 2021-08-19 2023-02-28 계명대학교 산학협력단 국수나무 추출물을 유효성분으로 포함하는 모발성장 촉진 또는 탈모예방용 조성물
KR102610308B1 (ko) 2021-08-19 2023-12-06 계명대학교 산학협력단 국수나무 추출물을 유효성분으로 포함하는 모발성장 촉진 또는 탈모예방용 조성물

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