WO2016208923A1

WO2016208923A1 - Safety filter and syringe having same

Info

Publication number: WO2016208923A1
Application number: PCT/KR2016/006531
Authority: WO
Inventors: 이재영; 임현철; 황원철
Original assignee: 주식회사 아모라이프사이언스
Priority date: 2015-06-23
Filing date: 2016-06-20
Publication date: 2016-12-29

Abstract

A syringe safety filter of the present invention comprises: a housing separably connected between a syringe needle and a cylinder; a passage member, which has an inflow passage provided at the housing and through which an injection fluid flows into the cylinder, and a discharge passage through which the injection fluid stored in the cylinder is discharged; and a filter member provided at the inflow passage of the passage member so as to filter foreign matter included in the injection fluid, and thus the syringe safety filter can prevent the foreign matter from flowing into the cylinder, and can reduce injection fluid discharge pressure by not allowing the injection fluid to pass through the filter member when the injection fluid is discharged from the cylinder.

Description

Safety filter and syringe with same

The present invention relates to a syringe, and more particularly, to a safety filter and a syringe having the same that can prevent foreign substances such as glass fragments and rubber fragments from being injected into the patient.

In general, the syringe includes a cylinder in which the injection liquid is stored, an injection needle mounted in front of the cylinder, and a plunger installed to be linearly movable in the cylinder to suck the injection liquid into the cylinder or discharge the injection liquid stored in the cylinder to the outside. .

Such a syringe cuts the upper portion of the ampoule vial containing the injection liquid to open the ampoule vial, and inserts an injection needle through the opened space to store the injection liquid into the cylinder.

In addition, in the case of a vial container in which the injection liquid is stored and sealed with a rubber stopper, the syringe inserts the injection needle into the rubber stopper to inject the injection into the cylinder.

However, such a syringe, when cutting the ampoule vial, glass fragments are introduced into the ampoule vial and mixed in the injection solution. Then, when the needle is inserted through the rubber stopper into the vial container, the rubber debris penetrates into the injection needle or into the vial container.

When glass fragments or rubber fragments are mixed with the injection solution and injected into the patient's body, various diseases such as phlebitis and sepsis are caused. In order to solve the problem of such a syringe has been developed a syringe with a filter is provided, a typical example is disclosed in Korean Patent Publication No. 10-1222881.

However, the conventional filter needle as described above when the chemical liquid is filled into the syringe cylinder, foreign matter contained in the chemical liquid is filled into the syringe cylinder like the chemical liquid and discharged through the filter when the chemical liquid is discharged from the syringe cylinder, so the chemical liquid discharge pressure is increased. There is a problem that it is difficult to inject the drug solution to the patient accordingly.

In particular, the syringe is mainly used by nurses, but since there are many female nurses, when the needle is inserted into the patient and the injection pressure is injected by pressing the plunger of the syringe, when the discharge pressure of the liquid is increased, it is difficult to inject the medicine and may be misinjected. There is.

Accordingly, an object of the present invention is to provide a collection chamber for collecting foreign matters to prevent foreign matters from entering the cylinder and to reduce the injection liquid discharge pressure by preventing the injection liquid from passing through the filter member when discharging the injection liquid from the cylinder Accordingly, to provide a safety filter and a syringe having the same convenient to inject the injection solution to the patient.

Another object of the present invention is provided with a second check valve in front of the collection chamber to prevent the return of the injection liquid to the collection chamber when discharging the injection liquid filled in the cylinder and a safety filter that can prevent the waste of the injection liquid and the syringe having the same To provide.

Another object of the present invention is to use a membrane in the form of a nanofiber web having micropores formed by electrospinning as a filter member can greatly increase the porosity to reduce the flow resistance generated when the injection liquid passes through the filter member It is to provide a safety filter that can be minimized and a syringe having the same.

Still another object of the present invention is to provide a safety filter having a high compatibility and a syringe having the same since a safety filter can be mounted between a needle and a cylinder of a conventional disposable syringe.

In order to achieve the above object, the syringe safety filter of the present invention comprises a housing connected to the cylinder; A passage member installed in the housing and having an inflow passage through which the injection liquid is introduced into the cylinder and a discharge passage through which the injection liquid stored in the cylinder is discharged; And a filter member installed in the inflow passage of the passage member to filter foreign substances contained in the injection liquid.

The filter member may be composed of a membrane in the form of a nanofiber web having a three-dimensional microporous structure provided by electrospinning of a polymer material.

In addition, the filter member may be composed of a laminated structure of the membrane of the nanofiber web form and the porous support for supporting the membrane.

The housing may include a first housing in which a first insert is formed to be fitted to the needle, and a second housing in which a second insert is formed to be sealably coupled to the first housing and the cylinder is fitted to the first housing. .

The housing may include a first housing in which a needle is integrally formed, and a second housing sealably coupled to the first housing and fitted to a cylinder.

The membrane may be formed by electrospinning the spinning solution in which the electrospinable polymer material and the solvent are mixed at a predetermined ratio to prepare nanofibers, and accumulate the nanofibers to a predetermined thickness on the porous support.

The diameter of the nanofibers may be formed in 0.1 ~ 3.0㎛.

The porosity of the membrane may be formed to 70 ~ 80% of the total area of the membrane.

The porous support may be formed of a nonwoven fabric or a mesh of metal or resin material.

A collection chamber is formed at the center of the passage member to be connected to the inflow passage to collect foreign substances contained in the injection liquid, and a first check valve is formed at the front of the collection chamber to open only one-way flow in which the injection liquid is introduced into the cylinder. The rear side may be provided with a filter member.

A cover member to which the filter member is fixed is sealably coupled to an open rear of the collection chamber, and the cover member may include a second check valve to block the return of the injection liquid introduced into the cylinder to the collection chamber. Can be.

The discharge passage may be formed in plural at regular intervals in the circumferential direction on the outside of the collection chamber, and a third check valve may be formed to open only one-way flow from which the injection liquid is discharged from the cylinder.

The discharge passage may be equipped with an auxiliary filter member for filtering the foreign matter contained in the injection liquid discharged from the cylinder.

Syringe safety filter of the present invention is provided with a collecting chamber for collecting foreign matter to prevent foreign matter from entering into the cylinder, and when the injection liquid is discharged from the cylinder because the injection liquid does not pass through the filter member to reduce the injection pressure Therefore, it is convenient to inject the injection solution to the patient.

In addition, the second check valve is provided in front of the collection chamber to prevent the return of the injection liquid to the collection chamber when discharging the injection liquid filled in the cylinder to prevent waste of the injection liquid.

In addition, by using a membrane in the form of a nanofiber web having micropores formed by electrospinning as a filter member can greatly increase the porosity can minimize the flow resistance generated when the injection liquid passes through the filter member.

In addition, the safety filter can be mounted between the needle and the cylinder of the conventional disposable syringe can be used to improve the compatibility.

1 is an exploded perspective view of a syringe according to a first embodiment of the present invention.

2 is a cross-sectional view of a safety filter according to a first embodiment of the present invention.

3 is a cross-sectional view of a safety filter according to a second embodiment of the present invention.

4 is a cross-sectional view of the filter member according to the first embodiment of the present invention.

5 and 6 are operating state diagrams of the safety filter according to the first embodiment of the present invention.

7 is an exploded perspective view of a syringe with a safety filter according to a third embodiment of the present invention.

8 is a cross-sectional view of a safety filter according to a third embodiment of the present invention.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. In this process, the size or shape of the components shown in the drawings may be exaggerated for clarity and convenience of description. In addition, terms that are specifically defined in consideration of the configuration and operation of the present invention may vary depending on the intention or custom of the user or operator. Definitions of these terms should be made based on the contents throughout the specification.

1 and 2, the syringe according to the first embodiment of the present invention is installed in the cylinder 10 and the cylinder 10 is filled with the injection liquid so as to move linearly to inject the injection liquid into the cylinder 10 or The plunger 12 to be discharged, the needle 20 is mounted in front of the cylinder 10, and the separation between the needle 20 and the cylinder 10, the safety to remove foreign matter contained in the injection liquid And a filter 30.

The injection needle 20 includes a needle 22 and a first connector 24 to which the needle 22 is fixed and detachably connected to the safety filter 30. And, in front of the cylinder 10 is formed a second connecting portion 14 which is detachably connected to the safety filter 30.

The safety filter 30 is disposed in the

housings

80 and 82, one end of which is connected to the needle 20, the other end of which is connected to the cylinder 10, and the inside of the

housings

80 and 82, and the cylinder 10 at the center thereof. In the passage member 70 and the passage member 70 is formed in the inlet passage 32 through which the injection liquid is introduced, and the discharge passage 34 through which the injection liquid stored inside the cylinder 10 is discharged. It is installed to include a filter member 44 for filtering foreign matter contained in the injection solution.

The

housings

80 and 82 are firstly coupled to the first housing 80 and the first housing 80 having the first inserting portion 84 to which the first connecting portion 24 is fitted, and the second connecting portion. And a second housing 82 in which a second insertion portion 86 into which the 14 is fitted is formed.

The passage member 70 is tightly fixed to the inner surfaces of the

housings

80 and 82 and may be formed of a resin material, a silicone material, or a rubber material that is elastically deformable.

The passage member 70 is formed with an inflow passage 32 through which the injection liquid is injected into the cylinder, and the inflow passage 32 is equipped with a filter member 44 for filtering the injection liquid flowing into the cylinder 10. A discharge passage 34 through which the injection liquid stored in the cylinder 10 is discharged in the circumferential direction is formed outside the inflow passage 32.

In the center of the passage member 70 is formed a collecting chamber 40 for collecting foreign matter contained in the injection liquid flowing into the inflow passage 32, the one-way flow in which the injection liquid is injected into the cylinder in front of the collection chamber 40 Only the first check valve 50 is opened.

The first check valve 50 has an elastic rib 52 protruding in the form of a convex sphere in the cylinder direction, and is formed in the form of a cut in the center of the elastic rib 52 so as to open when the pressure is applied from the inside. It includes.

When the pressure is applied from the concave portion to the convex portion, the first check valve 50 opens the flow while the incision 54 is opened, and when the pressure is applied to the concave portion, the incision hole 54 is closed. Keep the flow off.

The cover member 42 is fixed to the rear of the collection chamber 40 in a sealable manner. The cover member 42 is fitted to the open rear of the collecting chamber 40 and the filter member 44 is fixed to an inner surface thereof.

As such, since the safety filter 30 of the present invention includes the collecting chamber 40, only the clean injection liquid collected in the collection chamber 40 and the foreign matter contained in the injection liquid are filtered by the filter member 44. Flows into).

The cover member 42 is provided with a second check valve 46 which prevents the injection liquid stored in the cylinder 10 from being returned to the collection chamber 40. The second check valve 46 is the same as the configuration of the first check valve 50 described above, and is integrally formed with the cover member 42.

If the second check valve 46 is not installed, when the injection liquid is discharged from the cylinder 10, the injection liquid stored in the cylinder 10 is returned to the collection chamber 40 to store the injection liquid in the collection chamber 40. Can be. As such, since the injection liquid stored in the collection chamber 40 cannot be discharged to the outside, waste of the injection liquid may be generated as much as the injection liquid stored in the collection chamber 40.

However, in the present invention, the second check valve 46 is formed on the cover member 42 to prevent the injection liquid stored in the cylinder 10 from being returned to the collection chamber 40, thereby preventing waste of the injection liquid.

The discharge passage 34 is formed in plural at regular intervals in the circumferential direction on the outer side of the collecting chamber 40. A third check valve 48 is formed in the discharge passage 34 to close the discharge passage 34 when the injection liquid flows into the cylinder 10, and discharge passage 34 when the injection liquid is discharged from the cylinder 10. To open.

The third check valve 48 has the same structure as the first check valve 50, but only in opposite directions.

As a second embodiment of the safety filter, as shown in FIG. 3, an auxiliary filter member 72 is disposed in the discharge passage 34. The auxiliary filter member 72 is formed in the shape of a disk and mounted at the inlet of the discharge passage 34 to filter foreign substances contained in the injection liquid when the injection liquid stored in the cylinder 10 is discharged to the discharge passage 34.

That is, the filter member 44 filters the foreign matter contained in the injection liquid flowing into the cylinder 10 firstly and stores it in the cylinder 10, and the auxiliary filter member 72 when the injection liquid stored in the cylinder 10 is discharged. Secondary filtering improves the filtering performance of the injection solution.

As shown in FIG. 4, the filter member 44 is formed in the form of a nanofiber web having a porous support 60 and a three-dimensional microporous structure laminated on the porous support 60 and provided by electrospinning a polymer material. Which is a membrane 62.

In the exemplary embodiment of the present invention, the filter member 44 is illustrated and described with respect to the structure in which the porous support 60 and the membrane 62 in the form of a nanofiber web are stacked. However, the filter member 44 may be composed of only the membrane in the form of a nanofiber web. Alternatively, a plurality of layers of such membranes may be laminated.

Herein, the membrane 62 may be stacked on one surface of the porous support 60, may be stacked on both sides of the porous support 60, and the porous support 60 may be stacked on both sides of the membrane 62. have. In addition, the porous support 60 and the membrane 62 may be laminated in two or more layers when it is necessary to improve the filtering capability according to the purpose of use.

The membrane 62 is made of a spinning solution in which the electrospinable polymer material and a solvent are mixed at a predetermined ratio, and when the spinning solution is electrospun, nanofibers are prepared, and when the nanofibers are accumulated at a predetermined thickness on the porous support 60, It is formed in the form of a nanofiber web having fine pores that can filter foreign matter.

It is preferable that the diameter of a nanofiber shall be 0.1-3.0 micrometers.

The membrane 62 is freely adjusted in thickness depending on the time it is emitted from the electrospinning apparatus, and the pore size and porosity are determined by the thickness of the nanofiber web.

Therefore, in this embodiment, the pore size and porosity of the membrane 62 can be freely adjusted, and thus the pore size can be variously manufactured according to the filtration type.

In the case of conventional filters, the porosity of the membrane is about 40-50% of the total membrane area. In this case, the flow resistance of the injection liquid passing through the membrane is increased, which causes a lot of force when injecting the injection liquid into the cylinder, which is inconvenient to use.

In particular, because of the characteristics of the syringe is weaker than the male nurse is mainly used a lot, when a lot of strength when injecting the injection is difficult to use the syringe and there is a fear that a mistake occurs when using a lot of syringes.

In the present invention, the membrane 62 accumulates nanofibers by electrospinning to form a nanofiber web, thereby forming a porosity of the membrane 62 to 70 ~ 80% of the total area of the membrane 62 Accordingly, the flow resistance of the injection liquid passing through the membrane 62 may be minimized.

The porous support 60 may be formed of a nonwoven fabric or a mesh of metal or resin material. The porous support 60 may use any support as long as it has a pore through which the injection solution can pass and can support the membrane 62.

As the polymer material used in the present invention, electrospinning is possible, and examples thereof include hydrophilic polymers and hydrophobic polymers, and these polymers may be used alone or in combination of two or more thereof.

The polymer material usable in the present invention is not particularly limited as long as it can be dissolved in an organic solvent for electrospinning and can form nanofibers by electrospinning. For example, polyvinylidene fluoride (PVdF), poly (vinylidene fluoride-co-hexafluoropropylene), perfuluropolymer, polyvinylchloride, polyvinylidene chloride or copolymers thereof, polyethylene glycol di Polyethylene glycol derivatives including alkyl ethers and polyethylene glycol dialkyl esters, poly (oxymethylene-oligo-oxyethylene), polyoxides including polyethylene oxide and polypropylene oxide, polyvinylacetate, poly (vinylpyrrolidone- Vinyl acetate), polystyrene and polystyrene acrylonitrile copolymers, polyacrylonitrile (PAN), polyacrylonitrile copolymers including polyacrylonitrile methyl methacrylate copolymers, polymethyl methacrylate, polymethyl methacrylate Acrylate copolymers or mixtures thereof.

In addition, the polymer materials that can be used include polyamide, polyimide, polyamideimide, poly (meth-phenylene isophthalamide), polysulfone, polyetherketone, polyetherimide, polyethylene terephthalate, and polytrimethylene terephthalate. , Aromatic polyesters such as polyethylene naphthalate, and the like, polyphosphazenes such as polytetrafluoroethylene, polydiphenoxyphosphazene, poly {bis [2- (2-methoxyethoxy) phosphazene], polyurethane and Polyurethane copolymers including polyetherurethane, cellulose acetate, cellulose acetate butyrate, cellulose acetate propionate and the like.

Particularly preferred as the filter material of the present invention of the polymer material is PAN, polyvinylidene fluoride (PVdF), polyester sulfone (PES: Polyester Sulfone), polystyrene (PS) alone or polyvinylidene fluoride ( PVdF) and polyacrylonitrile (PAN) may be mixed, or PVdF and PES, PVdF and thermoplastic polyurethane (TPU) may be mixed and used.

In this way, the operation of the safety filter installed in the configured syringe is described below.

Open the ampule vial by cutting the upper part of the ampoule vial containing the injection solution, and insert the needle through the opened space. In the case of a vial container sealed with a rubber stopper, the needle is inserted into the rubber stopper to insert the needle into the vial container.

As shown in FIG. 5, when the plunger 12 is pulled, negative pressure is generated in the cylinder, and the injection liquid is injected into the needle 20. Then, the first check valve 50 is opened by the pressure of the injection liquid and the injection liquid flows into the collection chamber 40. The injection liquid introduced into the collection chamber 40 is filtered while passing through the filter member 44, and foreign matters such as glass fragments or rubber fragments are collected in the collection chamber 40.

In addition, the second check valve 46 is opened by the pressure of the injection liquid that has passed through the filter member 44, and the injection liquid is stored in the cylinder 10.

As such, the injection liquid stored in the cylinder 10 is filtered while the injection liquid passes through the filter member 44.

6, when the needle 20 is inserted in the patient and the plunger 12 is pressed, the injection liquid is discharged into the discharge passage 34 and the third check valve 48 is opened by the pressure of the injection liquid. Open to inject the injection into the patient. At this time, the injection liquid stored in the cylinder 10 can be prevented from being returned to the collection chamber 40 by the second check valve 46, thereby preventing waste of the injection liquid.

And, since the safety filter 30 of the present invention is detachably connected between the needle 20 and the cylinder 30, the safety filter 30 can be installed and used in the existing syringe, and the injection liquid in the cylinder 10. After storing the separation of the safety filter 30 and the cylinder 10 can also be used by mounting the needle 20 directly.

As shown in FIGS. 7 and 8, the syringe according to the third embodiment is installed in a cylinder 10 filled with the injection liquid and is linearly movable in the cylinder 10 to inject or discharge the injection liquid into the cylinder 10. The plunger 12 and the safety filter 100 is mounted to the front of the cylinder 10 and the needle is integrally formed.

The safety filter 100 according to the third embodiment is disposed in the

housings

102 and 104, which are fitted to the cylinder 10, in the

housings

102 and 104, and an inflow passage through which the injection liquid flows into the cylinder 10 at the center ( 32 is formed, the passage member 70 is formed at the edge of the discharge passage 34 for discharging the injection liquid stored in the cylinder 10, and installed in the passage member 70 to filter foreign matter contained in the injection liquid And a filter member 44.

The

housings

102 and 104 are made of a first housing 102 in which the needle 22 is integrally formed, and sealingly coupled to the first housing 102 and fitted to the inlet portion 14 of the cylinder 10. And two housings 104.

The first housing 102 has an injection needle 22 integrally formed at one side thereof, and a passage member 70 is adhered to the inside of the first housing 102 or fixed by bonding.

In addition, the second housing 104 may be screwed, bonded, or fitted to the first housing 102, and may be fitted to the inlet portion 14 of the cylinder 10.

Since the passage member 70 and the filter member 44 are the same as the passage member 70 and the filter member 44 described in the first and second embodiments, the description thereof will be omitted.

In the safety filter 100 according to the third embodiment, since the needle 22 is integrally formed in the first housing 102 and the safety filter 100 is mounted on the cylinder 10, the assembly is completed. It is convenient.

In the above, the present invention has been illustrated and described with reference to specific preferred embodiments, but the present invention is not limited to the above-described embodiments, and the present invention is not limited to the spirit of the present invention. Various changes and modifications will be possible by those who have the same.

The present invention prevents glass debris from entering the ampoule vial when mixing the ampoule vial, while minimizing the flow resistance of the injection fluid when injecting and discharging the injection, it is convenient to use, It can be mounted on disposable syringes for excellent compatibility.

Claims

A housing connected to the cylinder;

A passage member installed in the housing and having an inflow passage through which the injection liquid is introduced into the cylinder and a discharge passage through which the injection liquid stored in the cylinder is discharged; And

And a filter member installed in the inflow passage of the passage member to filter foreign substances contained in the injection liquid.
The method of claim 1,

The filter member is a syringe safety filter comprising a nanofiber membrane of a three-dimensional network structure having fine pores provided by the electrospinning of the polymer material.
The method of claim 1, wherein the filter member,

Porous support; And

And a nanofiber membrane having a three-dimensional network structure stacked on the porous support and having micropores provided by electrospinning of a polymer material.
The method of claim 1,

The housing includes a first housing having a first insert formed therein to be fitted into the needle, and a second housing having a second insert formed therein to be sealably coupled to the first housing and fitted with the cylinder. filter.
The method of claim 1,

The housing includes a first housing in which the needle is integrally formed, and a second housing sealably coupled to the first housing and fitted into the cylinder.
The method of claim 3,

The diameter of the nanofibers syringe safety filter of 0.1 ~ 3.0㎛.
The method of claim 3,

The porosity of the membrane is 70 to 80% of the total safety area of the syringe safety filter.
The method of claim 3,

The porous support is a syringe safety filter formed of a non-woven fabric or a mesh of metal or resin material.
The method of claim 1,

In the center of the passage member is connected to the inlet passage is formed a collection chamber for collecting the foreign matter contained in the injection liquid,

A first safety valve is formed at the front of the collection chamber to open only one-way flow in which the injection liquid is introduced into the cylinder, and a filter member is provided at the rear thereof.
The method of claim 9,

An open rear of the collection chamber is sealably coupled to the cover member to which the filter member is fixed.

The cover member is provided with a syringe safety filter is provided with a second check valve to block the return of the injection liquid introduced into the cylinder to the collection chamber.
The method of claim 9,

The discharge passage is formed in the plurality of discharge passages in the circumferential direction at a predetermined interval on the outside of the collection chamber, the syringe safety filter is formed with a third check valve for opening only one-way flow from which the injection liquid is discharged.
The method of claim 1,

The discharge passage is a syringe safety filter equipped with an auxiliary filter member for filtering the foreign matter contained in the injection liquid discharged from the cylinder.
A needle, a cylinder storing the injection liquid, and a safety filter detachably mounted between the needle and the cylinder to remove foreign substances contained in the injection liquid,

The safety filter is a syringe according to any one of claims 1 to 12.