KR102421794B1 - Medical filter and manufacturing method thereof - Google Patents

Abstract

The medical filter of the present invention comprises a filter member formed in the form of a nanofiber web having micropores by electrospinning a polymer material, and a support attached to one or both edges of the filter member in the circumferential direction to support the filter member Therefore, it is convenient to install the filter in the medical device while minimizing the flow resistance of the chemical.

Description

Medical filter and manufacturing method thereof

The present invention relates to a medical filter used in medical devices such as a syringe, an infusion filter, and a blood separation device, and a method for manufacturing the same.

In general, the syringe cuts the upper part of the ampoule glass bottle containing the injection solution to open the ampoule glass bottle, and inserts the injection needle through the opened space to suck the injection solution into the cylinder.

In addition, when the syringe is a vial container in which the injection solution is stored and sealed with a rubber stopper, the injection needle is inserted into the rubber stopper to inject the injection solution into the cylinder.

However, in the above syringe, when cutting the ampoule glass bottle, glass fragments are introduced into the ampoule glass bottle and mixed with the injection solution. And, when the injection needle passes through the rubber stopper and is inserted into the vial container, the rubber fragments penetrate into the injection needle or the vial container.

When glass fragments or rubber fragments are mixed with the injection solution and injected into the patient's body, various diseases such as phlebitis and sepsis are induced. In order to solve the problems of such a syringe, a syringe filter cap has been developed.

As disclosed in Patent No. 10-1460465 (November 04, 2014), the conventional syringe filter cap is a syringe filter cap that filters foreign substances such as rubber pieces and glass pieces from the injection solution by binding to the needle assembly, and a syringe filter. A housing forming the body of the cap, a hub insertion path formed inside the housing and into which the hub of the needle assembly is inserted and fixed, and a ramp extending from the hub insertion path and allowing the needle of the needle assembly to be inserted without jamming And, a needle insertion path extending from the slope and into which the needle of the needle assembly is inserted, a filter attached to the front end of the needle insertion path by melt-adhesion, and extending from the needle insertion path and the front is An open injection liquid inlet, a ventilation groove formed on the outer surface of the housing of the needle insertion passage and through which air passes, and a stripping belt formed on the outer surface of the housing of the hub insertion passage, the front of the housing It is composed of a housing coupling part into which an accessory is inserted and fixedly coupled, and a tubular metal tip having an open front and a tip penetrating the rubber stopper of the vial in an inclined shape.

Such a syringe filter cap is equipped with a metal tip at the end of the housing so that it can penetrate through the rubber stopper of the vial container.

However, in the conventional filter cap, the filter is melt-adhered to the needle insertion path. Because the inner diameter of the needle insertion path is small, it is difficult to adhere the filter to the needle insertion path. There is a problem in that it is difficult to properly perform the filter function.

Patent Document 1: Registered Patent Publication No. 10-1460465 (November 04, 2014)

Accordingly, it is an object of the present invention to provide a medical filter having a support capable of supporting the filter member on one or both edges of the filter member, so that the filter member can be conveniently mounted on a medical device.

Another object of the present invention is to use a filter member in the form of a nanofiber web having micropores formed by electrospinning, so that the porosity can be significantly increased, thereby minimizing the flow resistance generated when the chemical solution passes through the filter member. It is to provide a medical filter.

Another object of the present invention is to use a filter member in the form of a nanofiber web having micropores formed by electrospinning, so that the pore size can be adjusted in the process of manufacturing the filter member, so that the medical filter can be applied to various medical devices. and to provide a method for manufacturing the same.

Another object of the present invention is to provide a method for manufacturing a medical filter capable of improving productivity by more easily assembling between a filter member and a support having a small size.

In order to achieve the above object, the medical filter of the present invention is formed by electrospinning a spinning solution in which an electrospun polymer material and a solvent are mixed in a certain ratio to produce nanofibers, and accumulating the nanofibers on a porous support and A filter member having micropores, and attached to the edge of one or both sides of the filter member in the circumferential direction to support the filter member, PET, PP, PE, PC (Poly Carbonate), PTFE (Polytetrafluoroethylene), It may include a support formed of any one of POM (polyacetal).
The nanofiber may have a diameter of 200 nm to 400 nm, and the porosity of the filter member may be formed to be 55 to 85% of the total area of the filter member.
A medical filter manufacturing method includes the steps of forming a guide hole in a corner portion of a support, forming an inner hole through which a filter member is exposed on an inner surface of the support, a guide hole formed in the support on the guide rod, and a guide formed in the filter member It may include the steps of aligning the support and the filter member by inserting a hole, bonding the support and the filter member to each other, and punching out the outer surfaces of the support and the filter member.
The support and the filter member may be bonded to each other using thermal fusion, ultrasonic fusion, laser fusion, high frequency fusion, adhesive tape, or adhesive.

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As described above, the medical filter of the present invention is provided with a support capable of supporting the filter member on one or both edges of the filter member, so that it is convenient to install the filter member in a medical device. can be minimized.

In addition, the medical filter of the present invention uses a filter member in the form of a nanofiber web having micropores formed by electrospinning, so that the porosity can be significantly increased, thereby minimizing the flow resistance generated when the chemical solution passes through the filter member. can do.

In addition, the medical filter of the present invention uses a filter member in the form of a nanofiber web having micropores formed by electrospinning, so that the pore size can be adjusted in the process of manufacturing the filter member, so that it can be applied to various medical devices. .

In addition, the medical filter manufacturing method of the present invention can more easily assemble between the filter member and the support having a small size, thereby improving productivity.

1 is a cross-sectional view of a medical filter according to an embodiment of the present invention.
2 is a perspective view of a medical filter according to an embodiment of the present invention.
3 is a cross-sectional view of a medical filter according to a second embodiment of the present invention.
4 is a cross-sectional view of a medical filter according to a third embodiment of the present invention.
5 to 8 are process flowcharts illustrating a manufacturing process of a medical filter according to an embodiment of the present invention.

Hereinafter, an embodiment according to the present invention will be described in detail with reference to the accompanying drawings. In this process, the size or shape of the components shown in the drawings may be exaggerated for clarity and convenience of explanation. In addition, terms specifically defined in consideration of the configuration and operation of the present invention may vary depending on the intention or custom of the user or operator. Definitions of these terms should be made based on the content throughout this specification.

1 and 2, the medical filter according to an embodiment of the present invention includes a filter member 10 formed in the form of a nanofiber web having micropores by electrospinning a polymer material, and the filter member 10 It is laminated on one or both sides to support the filter member and includes a support 20 serving to fix the filter member to the medical device.

Such medical filters may be installed in medical devices such as syringes, infusion filters, blood separators, and medical air purifiers.

The support 20 is mounted in the circumferential direction along the edge of the filter member 10 to support the filter member 10 and to fix the filter member 10 to the medical device.

For example, when the medical filter is circular, the support 20 is formed as a circular ring with an open center, and when the medical filter has a polygonal shape, the support 20 is formed with a polygonal ring with an open center.

The support 20 is a film made of a polymer material, such as PET, PP, PE, PC (Poly Carbonate), PTFE (Polytetrafluoroethylene), POM (Polyacetal).

In addition, the support 20 may use silicone, non-woven fabric, or mesh in addition to the polymer film.

In the case of the existing filter, the support is formed of a porous material and is formed to cover the entire surface of the filter member. Weak support.

In the medical filter of the present invention, since the support 20 is attached only to the edge of the filter member 10 , the chemical solution passes only through the filter member 10 . Accordingly, it is possible to more firmly support the filter member 10 while reducing the flow resistance of the chemical.

The support 20 and the filter member 10 may be bonded to each other by thermal fusion, ultrasonic fusion, high frequency fusion, laser fusion, double-sided adhesive tape, or adhesive.

The support 20 may include a first support 22 and a second support 24 attached to both surfaces of the filter member 10 .

In addition, as shown in FIG. 3 , the medical filter may be formed in a structure in which the support 30 is attached to only one surface of the filter member 10 .

In addition, the medical filter may be formed in multiple layers depending on the purpose of use. That is, as shown in FIG. 4 , the first supporter 32 , the first filter member 12 , the second supporter 34 , the second filter member 14 and the third supporter 36 are sequentially stacked. It can be formed in the form

The filter member 10 makes a spinning solution in which an electrospun polymer material and a solvent are mixed in a certain ratio, and when this spinning solution is electrospun, nanofibers are manufactured, and when the nanofibers are accumulated to a certain thickness, foreign substances can be filtered. It is formed in the form of a nanofiber web with micropores.

The nanofiber may have a diameter of 200 nm to 400 nm.

In addition, the porosity of the filter member 10 may be formed to be 55 to 85% of the total area of the filter member 10 , and the average pores of the filter member 10 may be formed to be 1.5 μm to 4 μm.

And, the thickness of the filter member 10 may be formed to be 3 ~ 4㎛.

The thickness of the filter member 10 is freely adjusted according to the time radiated by the electrospinning device, and the pore size and porosity are determined according to the thickness of the nanofiber web.

Therefore, in this embodiment, the pore size and porosity of the filter member 10 can be freely adjusted, so that the pore size and porosity can be manufactured in various ways according to the type of medical device.

In the case of a conventional filter, the porosity of the filter member is about 40-50% of the total membrane area. In this case, the flow resistance of the injection solution passing through the filter member is increased, so that a lot of force is required to inject the injection solution into the cylinder, which is inconvenient to use.

In the present invention, the filter member 10 accumulates nanofibers by electrospinning to form a nanofiber web, so that the porosity of the filter member 10 is 70 to 80% of the total area of the filter member 10. And thus, it is possible to minimize the flow resistance of the injection solution passing through the filter member (10).

The polymer material used in the present invention is capable of electrospinning and includes, for example, a hydrophilic polymer and a hydrophobic polymer, and one or a mixture of two or more of these polymers may be used.

The polymer material usable in the present invention is not particularly limited as long as it is a resin that can be dissolved in an organic solvent for electrospinning and can form nanofibers by electrospinning. For example, polyvinylidene fluoride (PVdF), poly(vinylidene fluoride-co-hexafluoropropylene), perfluoropolymer, polyvinyl chloride, polyvinylidene chloride or copolymers thereof, polyethylene glycol di Polyethylene glycol derivatives including alkyl ethers and polyethylene glycol dialkyl esters, poly(oxymethylene-oligo-oxyethylene), polyoxides including polyethylene oxide and polypropylene oxide, polyvinyl acetate, poly(vinylpyrrolidone- vinyl acetate), polystyrene and polystyrene acrylonitrile copolymer, polyacrylonitrile (PAN), polyacrylonitrile copolymer including polyacrylonitrile methyl methacrylate copolymer, polymethyl methacrylate, polymethyl methacrylate acrylate copolymers or mixtures thereof.

In addition, available polymer materials include polyamide, polyimide, polyamideimide, poly(meta-phenylene isophthalamide), polysulfone, polyetherketone, polyetherimide, polyethylene terephthalate, polytrimethylene terephthalate. , aromatic polyesters such as polyethylene naphthalate, polyphosphazenes such as polytetrafluoroethylene, polydiphenoxyphosphazenes, poly{bis[2-(2-methoxyethoxy)phosphazenes]}, polyurethanes and Polyurethane copolymers including polyether urethane, cellulose acetate, cellulose acetate butyrate, cellulose acetate propionate, and the like.

Among the polymer materials, particularly preferred as the filter material of the present invention are PAN, polyvinylidene fluoride (PVdF), polyester sulfone (PES: Polyester Sulfone), polystyrene (PS) alone, or polyvinylidene fluoride ( PVdF) and polyacrylonitrile (PAN) may be mixed, or PVdF and PES, or PVdF and thermoplastic polyurethane (TPU: Thermoplastic Polyurethane) may be mixed.

Next, the manufacturing process of the medical filter will be described.

5 to 8 are process flow charts showing a medical filter manufacturing process according to an embodiment of the present invention.

First, the support 20 is prepared. The support 20 is a film made of a polymer material, such as PET, PP, PE, PC (Poly Carbonate), PTFE (Polytetrafluoroethylene), POM (Polyacetal). The support 20 is formed in the form of a square plate.

Then, as shown in FIG. 5 , a guide hole 40 is formed in a corner portion of the support 20 .

Then, as shown in FIG. 6 , the support 20 is punched to form the inner hole 42 . Here, the inner hole 42 is a portion to which the filter member 10 is exposed when the support 20 and the filter member 10 are bonded to each other. The inner hole 42 may be punched using a laser or a press.

And, as shown in FIG. 7 , the support 20 and the filter member 10 are aligned with the jig 50 . That is, the guide hole 40 of the support 20 is inserted into the guide rod 52 of the jig 50 , and similarly inserted into the guide hole 54 formed at the edge of the filter member 10 . At this time, when the support 20 is disposed on both sides of the filter member 10 , the support 20 is arranged on both sides of the filter member 10 , and when the support 20 is one sheet, one surface of the filter member 10 . Arrange the supports only on the

Then, the support 20 and the filter member 10 are bonded together. The bonding method may be thermal welding, ultrasonic welding, laser welding, high-frequency welding, or bonding using an adhesive tape and an adhesive.

When bonding between the support 20 and the filter member 10 is completed, as shown in FIG. 8 , the outer surfaces of the support 20 and the filter member 10 are punched out to manufacture a medical filter suitable for a medical device.

In the above, the present invention has been illustrated and described with examples of specific preferred embodiments, but the present invention is not limited to the above-described embodiments, and within the scope of not departing from the spirit of the present invention, common knowledge in the technical field to which the present invention belongs Various changes and modifications will be possible by those who have

10: filter member 20: support
22: first support 22: second support
24: second support 40: guide hole
42: inner hole 50: jig

Claims (10)

delete delete Forming a guide hole in the edge portion of the support;
forming an inner hole through which the filter member is exposed on the inner surface of the support;
aligning the support and the filter member by inserting the guide hole formed in the support and the guide hole formed in the filter member in the guide rod;
bonding the support and the filter member to each other; and
A medical filter manufacturing method comprising the step of punching out the outer surfaces of the support and the filter member. 4. The method of claim 3,
The step of bonding the support and the filter member to each other is a method of manufacturing a medical filter, characterized in that the bonding is performed using heat welding, ultrasonic welding, laser welding, high frequency welding, adhesive tape or an adhesive.
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