WO2016205987A1 - 一种样本分析装置 - Google Patents

一种样本分析装置 Download PDF

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Publication number
WO2016205987A1
WO2016205987A1 PCT/CN2015/082002 CN2015082002W WO2016205987A1 WO 2016205987 A1 WO2016205987 A1 WO 2016205987A1 CN 2015082002 W CN2015082002 W CN 2015082002W WO 2016205987 A1 WO2016205987 A1 WO 2016205987A1
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WO
WIPO (PCT)
Prior art keywords
sample
channel
storage
card slot
sample holder
Prior art date
Application number
PCT/CN2015/082002
Other languages
English (en)
French (fr)
Inventor
王志红
佘法停
周鹏
Original Assignee
深圳迈瑞生物医疗电子股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 深圳迈瑞生物医疗电子股份有限公司 filed Critical 深圳迈瑞生物医疗电子股份有限公司
Priority to PCT/CN2015/082002 priority Critical patent/WO2016205987A1/zh
Priority to EP15895887.6A priority patent/EP3312614A4/en
Priority to CN201580079599.5A priority patent/CN107533074B/zh
Publication of WO2016205987A1 publication Critical patent/WO2016205987A1/zh
Priority to US15/851,470 priority patent/US11137411B2/en
Priority to US17/411,720 priority patent/US11639942B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/1083—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with one horizontal degree of freedom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0412—Block or rack elements with a single row of samples
    • G01N2035/0415—Block or rack elements with a single row of samples moving in two dimensions in a horizontal plane
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0418—Plate elements with several rows of samples

Definitions

  • the present application relates to a sample analysis device, and more particularly to a sample analysis device for a sample rack injection method.
  • the sample transmission method in the automatic analysis device has a sample tray injection method and a sample rack rail injection method. Due to its simple structure and low cost, the sample tray is widely used in low-end models. However, using the sample tray transmission method, it is not convenient for the user to load the sample after the test starts or to unload the sample after the sample is taken.
  • the prior art sample rack orbital injection transmission scheme generally has the characteristics of complex structure, large space, and high cost, but it can support a large sample because it can support the sample loading or removing the sample that has been sampled. Continuous and efficient testing in volume application mode is therefore widely used in mid- to high-end analytical devices.
  • the sample rack transmission is usually in the order of placement, the queue is sequentially entered into the scanning position and the aspiration position, the emergency response speed is affected, and for samples that require automatic retesting, often Need to re-enter the put-in area to wait in line, extending the re-testing day.
  • the transmission of the sample rack is not serially transmitted according to the insertion order, but the sample holder is taken from any position of the sample rack storage area by a robot, and after the sample holder is rotated by 90 degrees, the sample is taken. After the rack is transported to the scanning position and the sampling position is completed, the sample rack is returned to the sample rack storage area.
  • This solution takes up a lot of space and increases the complexity of the mechanism due to the need to translate and rotate the sample holder.
  • the present application provides a sample analysis device based on a sample rack injection method, the sample rack transmission does not need to be serially transmitted according to the insertion order, and the sample rack transmission, the information reading, and the compactness between the parts of the sample are compact. , Take up little space.
  • An embodiment of the present application provides a sample analysis device, including:
  • a plurality of side-by-side storage channels are arranged in the sample storage area, the storage channels are used for placing the sample racks, and a plurality of sample containers can be placed on each sample rack;
  • a transport mechanism comprising a card slot for placing the sample holder, a toggle mechanism, and a first motion mechanism for driving the card slot and the toggle mechanism to move in the first direction, the first direction being on the horizontal plane and storing An axially perpendicular direction of the channel, the card slot and the toggle mechanism are fixed on the first motion mechanism, the axial direction of the card slot is consistent with the axial direction of the storage channel, and the first motion mechanism passes perpendicular to The first direction movement of the axial direction of the storage passage allows the card slot and the dialing mechanism to be aligned with any one of the storage passages, and the toggle mechanism includes a dial for pushing or pulling the sample holder and a second movement mechanism, the second movement The mechanism is configured to drive the dial to move in a second direction parallel to the axial direction of the storage passage, and the dialer realizes the sample rack in each storage passage and the card slot at least driven by the first motion mechanism and the second motion mechanism Movement between
  • the sample suction channel is at least partially located in the movement of the card slot and parallel to the axial direction of the storage channel, and a suction sample is arranged on the sample channel, and in the suction phase, the first motion mechanism drives the card slot to move To the suction channel, the toggle mechanism causes the sample on the sample holder to pass through the aspiration site in sequence, and the suction sample is used for the purpose of aspiration operation.
  • a space is designed as a sample suction channel in the movement of the card slot, and only one suction sample coordinate is arranged on the sample channel, and the design of the sample channel and the storage channel and the card slot is adopted.
  • the transport mechanism only needs to do two-dimensional movement to transport the sample rack to the sample suction position, so that the sample is finished in the sample position.
  • the solution of the present application not only optimizes the overall spatial layout of the device, but also simplifies the sampling mechanism. Structural design.
  • FIG. 1 is a schematic overall structural diagram of a sample analysis device according to an embodiment of the present application.
  • FIG. 2 is a partial structural diagram of a sample analysis device according to an embodiment of the present application.
  • FIG. 3 is a schematic structural view of a toggle mechanism according to an embodiment of the present application.
  • FIG. 4 is a schematic structural view of a blocking member according to an embodiment of the present application.
  • FIG. 5 is a perspective view of another embodiment of a storage channel and a card slot according to an embodiment of the present application;
  • FIG. 6 is a motion path diagram of a sample rack according to an embodiment of the present application;
  • FIG. 7 is a schematic diagram of the lifting height of the toggle mechanism according to an embodiment of the present application.
  • Embodiment 1 is a diagrammatic representation of Embodiment 1:
  • the sample analysis device typically operates according to the following procedures: injection, aspiration, reagent uptake, reaction, and subsequent treatment for different analytical items.
  • the sample analysis device includes a sample scheduling module 100, a sample aspiration module 200, and an information reader 300, and the sample scheduling module 100 is configured to transport a specified sample rack to a specified position. , and perform the specified action.
  • the sample scheduling module 100 includes a sample storage area 110 and a transport mechanism 120 that includes a sample aspiration channel 210 and a sample aspiration mechanism 220.
  • the sample storage area 110 can be realized by a platform.
  • the sample storage area 110 is provided with a plurality of parallel storage channels 111, and the adjacent storage channels are isolated, and do not affect each other.
  • the storage channel 11 1 is used for placing the sample rack 112.
  • one sample rack can be placed in one storage rack, and each sample rack 1 12 has a plurality of test tubes, which can carry a plurality of test tubes 113, and the test tubes 113 are used for holding samples. .
  • the user can place the sample holder in a storage channel 111.
  • the user can remove the sample holder from the storage channel 111.
  • the storage channel 11 1 has two ports.
  • the port for inserting and removing the sample rack by the user is defined as the near user end 11 la
  • the port for loading and removing the sample rack by the transport mechanism 120 is the near card. Slot end ll lb.
  • a sensor (not shown) is installed in each storage channel to identify whether the storage channel has a sample.
  • an indicator light 114 is mounted, as shown in FIG.
  • the sample analysis device controls different display states of the indicator light 114 according to the state of the sensor and the test state of each storage channel, and the user can conveniently distinguish the current state of each storage channel by the display state of the indicator light 114.
  • the indicator light can be off, the green light is on, the yellow light is on, and the green light is flashing.
  • the corresponding ones indicate that the storage channel is free, the storage channel is placed in the sample rack (that is, the test has not been started), and the storage channel is working (including the selection start). After the test, the sample rack is taken away by the transport organization, and the automatic retest wait test knot is set. If the indicator light indicates that the storage channel sample holder has been tested, the user can remove the sample holder of the storage channel.
  • the transport mechanism 120 is disposed in a front area of the near-card slot end 111b of the storage passage 111, including a first motion mechanism 121, a card slot 122, and a toggle mechanism (not shown in FIG. 2).
  • the first motion mechanism 121 is adapted to move in a first direction (X direction as shown in the figure) perpendicular to the axial direction of the storage passage on a horizontal plane.
  • the first motion mechanism 121 includes a drive chain 1211 and a base 1 212 that are transmitable in the X direction, and the base 1212 is secured to the drive chain 1211.
  • the card slot 122 is for accommodating the sample holder, which is fixed to the first movement mechanism 121, and the axial direction of the card slot 122 after the installation coincides with the axial direction of the storage passage.
  • the toggle mechanism is also fixed on the first motion mechanism 121. Specifically, the card slot 122 and the toggle mechanism are fixed on the base 1 212.
  • the drive chain 1211 When the drive chain 1211 is driven, the base 1212 can follow the drive chain 1211 in the X direction. Moving, thereby driving the card slot 122 and the toggle mechanism to move left and right in the X direction, so that the card slot 122 and the toggle mechanism can be aligned to any one of the storage channels 111 of the sample storage area by moving left and right.
  • the toggle mechanism is configured to grasp the sample rack in the contact sample rack, and when the toggle mechanism moves, the sample rack can be moved together.
  • the toggle mechanism 123 is located under the card slot, and includes a dialer 1231 for pushing the sample holder and a second motion mechanism 1232.
  • the second motion mechanism may specifically be a second transmission chain.
  • the second moving mechanism is configured to drive the dial to move back and forth in a second direction parallel to the axial direction of the storage passage (in the Y direction as shown in FIG.
  • the toggle mechanism 123 further includes a third motion mechanism 1233, the dialer 1231 is fixed to the third motion mechanism 1233, and the third motion mechanism 1233 drives the dial 1231 to move up and down.
  • the third motion mechanism 1233 may include a gear 1233a, a rack 1233b, and a motor 1233c.
  • the gear meshing mechanism is rotated by the motor 1233c driving gear 1233a, the gear 1233a and the rack 1233b are engaged to move the rack 1233b, and the dial 1231 is fixed to the rack.
  • the rack 1233b can drive the dial 1231 to move up and down.
  • the third moving mechanism 1233 and the dialing mechanism 1231 are fixed to the second moving mechanism 1232, and are driven to move back and forth in the Y direction by the second moving mechanism 1232.
  • the dial 1231 includes a long cross arm 1231a and a short vertical arm 1231b.
  • the vertical arm 1231b is disposed at both ends of the cross arm 1231a.
  • the length of the cross arm 1231a is slightly larger than the length of the sample holder, and the dial 1231 is movable in the second motion.
  • the third transport The moving mechanism 1233 drives the dial 1231 to rise, so that the cross arm 1231a abuts against the bottom of the sample holder, and the vertical arm 1231b is used to contact the two sides of the bottom of the sample holder at the moving jaw, so that the dial 1231 can be in the second movement.
  • the mechanism drives down or pulls the sample holder.
  • the dial 1231 can also capture the sample holder by magnetic attraction or abut against the bottom of the sample holder by elastic deformation.
  • the toggle mechanism may not have a third motion mechanism that drives the dial to move up and down, and the structure of the dialer may also be adapted for applicability.
  • the drive train described above can also be replaced with a rail or other mode of motion.
  • the sample suction mechanism 220 includes a moving mechanism 221 and a suction needle 222, and the suction needle 222 is mounted on the moving mechanism 221
  • the moving mechanism 221 is used to move the aspirating needle 222 to the aspirating position where the sample is located, and the aspirating needle 222 performs the aspirating operation on the sample.
  • the sample aspirating channel 210 is for accommodating the sample holder, and provides a sample aspirating position, which is a position at which the sample to be aspirated is located after the sample aspirating operation is performed.
  • the sample suction channel 210 is located in the stroke of the movement of the card slot 122 in the X direction, and is disposed in parallel with the axial direction of the storage channel 111.
  • the sample suction channel 210 is an area capable of accommodating the sample holder.
  • the first motion mechanism 121 drives the card slot 122 to move to the sample channel 210 to perform a sample suction operation.
  • the sample aspirating sample 211 is disposed on the sample aspirating channel 210, and the sample on the sample holder is sequentially transported to the aspirating sample 211 to perform a sample aspiration operation.
  • the length of the sample channel is at least twice the length of the sample holder.
  • the sample channel is arranged side by side in parallel with the storage channel and extends to the card. In the groove moving area, the sample suction position 211 is located in the central portion of the sample suction channel 210.
  • the aspiration channel is disposed adjacent the outermost storage channel, as shown in Figures 2 and 4, in some instances, the aspiration channel is disposed in the intermediate channel of the plurality of storage channels. In some instances, the sample channel may not be placed side by side with the storage channel, but rather extends from the area in which the card slot moves toward the area away from the storage channel.
  • the information reader 300 is used to acquire the sample information.
  • the information reader 300 may be a barcode scanner, or may be an RF card reader or an IC card reader.
  • the device is arranged to perform an information reading operation on the passing sample on the transport path between the sample rack and the sample suction position to perform the sample suction operation.
  • the information reader 300 is a barcode scanner, which is disposed along the suction channel, and can be specifically disposed in a central region on one side of the sample channel 210, for example, can be arranged side by side or sucked together with the sample site.
  • the sample positions are set in the same position.
  • the toggle mechanism moves the sample holder to move the sample holder out of the card slot 122 and sequentially advances along the sample channel 2 10 to the position of the information reader 300, when the sample reaches the position of the information reader 300. ⁇ , get sample information by barcode scanning. After all the samples on the sample holder pass the position of the information reader, the toggle mechanism drives the sample holder to move in the opposite direction, and the sample on the sample holder passes through the suction sample 2, and the sample is sucked in the sample. The purpose of the operation is to stay.
  • the operation process of this embodiment is as shown in FIG. 6, and includes the following steps.
  • the sample holder moves along the path 1.
  • the first motion mechanism moves in the X direction such that the card slot 122 is aligned with the predetermined storage channel 111.
  • the traverse moves along the Y direction toward the sample holder in the storage channel.
  • the sample holder is captured, and then moved backwards to the card slot 122 (shown by a thick broken line in FIG. 6), and the sample holder is moved into the card slot.
  • the sample rack initial position 123 (shown by the thin dotted line in Figure 3).
  • the sample holder moves along path 2.
  • the first motion mechanism moves the card slot placed in the sample holder in the X direction to enter the sample channel.
  • the sample holder moves along path 3.
  • the toggle mechanism pushes the sample holder, aligns the sample rack barcode with the scan window of the scanner 300, and performs a sample rack barcode scanning operation.
  • the dialing mechanism continues to push the sample rack out of the card slot, so that the samples on the sample rack are successively pushed by the cup position, and the samples are sequentially aligned with the scanning window to complete the sample rack and the 10 sample barcode scanning.
  • the sample holder moves along path 4.
  • the toggle mechanism pushes the sample holder to move in the opposite direction and moves the sample holder into the card slot.
  • the samples to be tested are sequentially stopped at the aspiration site, and the aspiration needle is moved to the aspiration site, and the sample is subjected to aspiration operation until the sample aspiration operation of all the samples is completed.
  • the sample holder moves along path 5.
  • the first motion mechanism moves in the X direction, so that the card slot is aligned with the predetermined storage channel
  • the sample holder moves along path 6.
  • the toggle mechanism moves in the Y direction and transports the sample holder above the storage channel.
  • the sample storage area there are a plurality of storage channels arranged side by side in parallel and separated from each other, and the first movement mechanism can be aligned with any storage channel according to the instruction, and the sample in the storage channel is used.
  • the racks are transported to the aspiration position, so they do not need to be serially transmitted in the order in which they are placed.
  • Each storage channel can be set to an emergency (priority) channel, which speeds up the emergency and retest response time.
  • the control software temporarily returns the sample rack in the current test to the corresponding storage channel, transports the emergency sample to the aspirating sample to perform the aspiration sample, and completes the emergency aspiration sample.
  • the emergency sample rack is transported back to the corresponding storage channel, and then the interrupted sample rack to be tested is transported to the sample suction position to continue the subsequent test.
  • the suction sample has only one position coordinate, and the design of the suction channel and the storage channel and the card slot allows the transportation mechanism to transport the sample to the sample position only by performing two-dimensional movement. Performing the aspirating operation not only optimizes the overall spatial layout of the sample analysis device, but also simplifies the structural design of the aspirating mechanism because the aspiration mechanism only needs to move to the same aspiration position to perform the aspiration operation.
  • the information reader can also be disposed along the card slot, for example, disposed at a port of the card slot adjacent to the storage channel, and the sample mechanism moves the sample holder into the card slot to read the sample information.
  • Embodiment 2 is a diagrammatic representation of Embodiment 1
  • the sample holder protrudes from the storage passage 111, and the storage passage is further provided with a blocking member.
  • the blocking members 115 and 116 respectively It is set at the two ports of the storage channel, and is used for placing the sample holder into the storage channel ⁇ limit, which can block the sample holder in the storage channel from extending out of the storage channel.
  • the front blocking member 115 and the rear blocking member 116 are respectively fixed steps disposed at the two ports of the storage passage, and the middle of the fixed step and the middle of the storage passage have a port 117 through which the dial can pass, and the third
  • the moving mechanism also drives the dial to lift and lift the sample holder through the step, and when the sample holder needs to enter the storage channel from the card slot or enter the card slot from the storage channel, the third motion mechanism drives the dial to rise and dial.
  • the cross arm 1231a of the actuator lifts the sample holder to pass the step; after the sample holder enters the card slot or the storage channel, the third motion mechanism drives the dial to lower, and places the sample holder on the card slot or the storage channel.
  • the sample holder moves along path 1.
  • the first motion mechanism moves in the X direction such that the card slot 122 is aligned with the predetermined storage channel 111.
  • the traverse moves in the Y position toward the sample holder in the storage channel at the height position 10, and after aligning the sample holder, moves upward, lifts the sample holder, raises it to the height position 30, and then reverses to the card slot 122 (Fig. Move the sample holder to the initial position 123 of the sample holder in the card slot (shown by the thin dotted line in Figure 6), then lower the pulley to the height position 20, and the height position 20 is also the bottom of the card slot. Height, place the sample holder on the sample holder initial position 123 on the card slot.
  • the sample holder moves along path 2.
  • the first motion mechanism moves the card slot placed in the sample holder in the X direction to enter the sample channel, and the last sample of the sample frame (such as sample No. 10) is near the position of the barcode scanner.
  • the sample holder moves along path 3.
  • the dialing mechanism pushes the sample holder at the height position 20, and the sample rack barcode is aligned to the scanning window to perform the sample rack barcode scanning operation. Then, the dialing mechanism continues to push the sample rack out of the card slot, so that the sample on the sample rack is progressively pushed by the cup position, and the sample position 10-1 is sequentially aligned with the scanning window to complete the sample rack and the 10 sample bit barcode scanning.
  • the sample holder moves along path 4.
  • the toggle mechanism pushes the sample holder to move in the opposite direction and moves the sample holder toward the card slot.
  • the sample holder moves along path 5.
  • the first motion mechanism moves in the X direction, so that the card slot is aligned with the predetermined storage channel
  • the sample holder moves along path 6.
  • the toggle mechanism is raised from the height position 20 to the height position 30, the sample holder is lifted, the toggle mechanism moves in the Y direction, the sample holder is transported above the storage passage, and the toggle mechanism is lowered to the height position 10, during the lowering process,
  • the sample holder is placed at the bottom height position 40 of the storage channel.
  • the blocking member may not be fixed, but movable, and when the toggle mechanism and/or the sample holder pass through the shackle, the blocking member is smashed to make the toggle mechanism and/or the sample holder Through the other days, the blocking member is closed, and the sample holder in the storage passage is prevented from extending out of the storage passage.

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Abstract

一种样本分析装置，包括样本存放区(110)、吸样通道(210)、运输机构(120)。样本存放区(110)设置多个并排的样本架(112)的存放通道(111)，吸样通道(210)与存放通道(111)平行设置，运输机构(120)包括第一运动机构(121)、卡槽(122)和拨动机构(123)，卡槽(122)和拨动机构(123)固定在第一运动机构(121)上，拨动机构(123)包括拨动器(1231)和第二运动机构(1232)，第一运动机构(121)可驱动卡槽(122)和拨动机构(123)通过左右移动对准任一个存放通道(111)，第二运动机构(1232)可驱动拨动器(1231)前后运动，实现样本架(112)在各个存放通道(111)和卡槽(122)之间的移动，吸样通道(210)上设置一吸样位(211)，运输机构(120)将样本架(112)从存放通道(111)移动到卡槽(122)上后，把需要吸样的样本依次定位到吸样位(211)上，完成吸样后，再将样本架(112)运回到存放通道(111)。样本分析装置优化了整体空间布局。

Description

说明书 发明名称：一种样本分析装置 技术领域
[0001] 本申请涉及一种样本分析装置， 尤其涉及样本架进样方式的样本分析装置。
[0002]
[0003] 背景技术
[0004] 目前自动分析装置中的样本传输方法， 常见的有样本盘进样方式和样本架轨道 进样方式。 样本盘因其结构简单且成本低， 被广泛应用在中低端机型。 但采用 样本盘传输方式， 不方便用户在测试幵始后随吋加载样本或者随吋卸载吸样完 成的样本。 现有技术中的样本架轨道进样传输方案， 普遍具有结构复杂， 占空 间大， 成本高的特点， 但由于它可支持随吋加载样本或取走已吸样完成的样本 ， 保证了大样本量应用模式下的连续高效测试， 因此被广泛应用于中高端的分 析装置中。
[0005] 但常见的样本架轨道进样方式， 样本架的传输通常是按放入顺序， 排队依次进 入扫描位和吸样位， 急诊响应速度受到影响， 并且对于需要自动重测的样本， 往往需要重新进入放入区排队等待， 延长了重测吋间。 为了解决急诊响应吋间 的问题， 往往需要从结构、 控制方法或操作步骤等方面进行设计， 才能改善急 诊影响速度的问题， 并且无法避免自动重测样本重新排队等待的问题。
[0006] 也有些现有技术， 样本架的传输不是按照放入顺序串行传输的， 而是通过机械 手， 从样本架存放区任意位置取走样本架， 将样本架旋转 90度后， 将样本架依 次运输到扫描位、 吸样位完成相关操作后， 再将样本架放回到样本架存放区。 这种方案占用空间较大， 且由于需要平移和旋转样本架， 因此增加了机构的复 杂度。
[0007]
[0008] 发明内容
[0009] 本申请提供一种基于样本架进样方式的样本分析装置， 样本架的传输不需要按 照放入顺序串行传输， 且样本架传输、 信息读取和吸样各部分之间结构紧凑， 占用空间小。
[0010] 本申请一种实施例中提供一种样本分析装置,包括：
[0011] 样本存放区， 在样本存放区设置有多个并排的存放通道， 存放通道用于放置样 本架， 每个样本架上可放置多个样本容器；
[0012] 运输机构， 其包括用于放置样本架的卡槽、 拨动机构和用于驱动卡槽和拨动机 构沿第一方向运动的第一运动机构， 第一方向为在水平面上与存放通道的轴向 垂直的方向拨动机构， 所述卡槽和拨动机构固定在第一运动机构上， 卡槽的轴 向与存放通道的轴向一致， 所述第一运动机构通过沿垂直于存放通道轴向的第 一方向运动可使卡槽和拨动机构对准任一个存放通道， 拨动机构包括用于推或 拉样本架的拨动器和第二运动机构， 所述第二运动机构用于驱动拨动器沿平行 于存放通道轴向的第二方向运动， 所述拨动器至少在第一运动机构和第二运动 机构的驱动下实现样本架在各个存放通道和卡槽之间的移动；
[0013] 吸样通道， 其至少部分位于卡槽移动的行程内， 并与存放通道的轴向平行， 吸 样通道上设置一吸样位， 在吸样环节， 第一运动机构带动卡槽移动到吸样通道 ， 拨动机构使样本架上的样本依次经过吸样位， 并在吸样位做以吸样操作为目 的的停留。
[0014] 本申请实施例中， 在卡槽移动的行程内设计一空间作为吸样通道， 吸样通道上 只有一个吸样位坐标， 通过吸样通道与存放通道和卡槽的配合设计， 使得运输 机构只需要做二维移动即可将样本架运输到吸样位， 使样本在该吸样位完成吸 样， 本申请的方案不但优化了设备的整体空间布局， 而且简化了吸样机构的结 构设计。
[0015]
[0016] 附图说明
[0017] 图 1为本申请一种实施例的样本分析装置的整体结构示意图；
[0018] 图 2为本申请一种实施例的样本分析装置的部分结构示意图；
[0019] 图 3为本申请一种实施例的拨动机构的结构示意图；
[0020] 图 4为本申请一种实施例的阻挡件结构示意图；
[0021] 图 5为本申请一种实施例的存放通道和卡槽另一角度的立体示意图; [0022] 图 6为本申请一种实施例的样本架运动路径图；
[0023] 图 7为本申请一种实施例的拨动机构升降高度示意图。
[0024]
[0025] 具体实施方式
[0026] 下面通过具体实施方式结合附图对本发明作进一步详细说明。
[0027] 实施例一：
[0028] 样本分析装置通常按照以下过程工作： 进样、 吸样、 吸试剂、 反应， 反应后再 针对不同的分析项目进行处理。
[0029] 本实施例中， 如图 1所示， 样本分析装置包括样本调度模块 100、 吸样模块 200 和信息读取器 300， 样本调度模块 100用于实现运输指定的样本架到指定的位置 ， 和执行指定的操作。 样本调度模块 100包括样本存放区 110和运输机构 120， 吸 样模块 200包括吸样通道 210和吸样机构 220。
[0030] 如图 1、 2所示， 样本存放区 110可通过一平台实现， 样本存放区 110上设置有多 个并排平行的存放通道 111， 相邻存放通道之间隔离幵， 互不影响， 存放通道 11 1用于放置样本架 112， 例如， 一个存放通道内可放入一个样本架， 每个样本架 1 12上具有多个试管位， 可承载多个试管 113， 试管 113用于盛装样本。 当样本架 上的样本需要分析吋， 用户可将该样本架放置在某一个存放通道 111中， 当样本 架上的样本已完成分析吋， 用户可将样本架从存放通道 111中取走。 存放通道 11 1具有两个端口， 为方便阐述， 定义由用户执行样本架放入和取走的端口为近用 户端 l l la， 由运输机构 120执行样本架放入和取走的端口为近卡槽端 l l lb。
[0031] 在较佳的具体实施例中， 为了便于区分每个存放通道的当前状态， 在每个存放 通道内安装有传感器 （图中未示出） ， 用来识别该存放通道是否放有样本架， 在每个存放通道 111的前侧， 安装有指示灯 114， 如图 1所示。 样本分析装置根据 传感器状态以及每个存放通道所处测试状态， 控制指示灯 114的不同显示状态， 用户通过指示灯 114的显示状态， 可以方便地区分每个存放通道当前的状态。 例 如， 指示灯可以有灭、 绿灯亮、 黄灯亮、 绿灯闪四种状态， 分别对应表示存放 通道空闲、 存放通道放入样本架 （即尚未幵始测试） 、 存放通道工作中 （包括 选择幵始后待测、 样本架被运输机构取走测试中、 设置了自动重测等待测试结 果等环节） 、 存放通道样本架完成测试， 当指示灯指示存放通道样本架完成测 试吋， 用户可将该存放通道的样本架取走。
[0032] 如图 2所示， 运输机构 120设置在存放通道 111的近卡槽端 111b的前方区域， 包 括第一运动机构 121、 卡槽 122和拨动机构 （图 2中未示出） 。 第一运动机构 121 用于在水平面上沿垂直于存放通道轴向的第一方向 （如图中所示 X方向） 运动。 在一种具体实例中， 第一运动机构 121包括可沿 X方向传动的传动链 1211和底座 1 212， 底座 1212固定在传动链 1211上。 卡槽 122用于容纳样本架， 其固定在第一 运动机构 121上， 卡槽 122在安装后的其轴向与存放通道的轴向方向一致。 拨动 机构也固定在第一运动机构 121上， 具体来说卡槽 122和拨动机构都固定在底座 1 212上， 当传动链 1211传动吋， 底座 1212可跟随传动链 1211在 X方向上左右移动 ， 从而带动卡槽 122和拨动机构在 X方向上左右移动， 使得卡槽 122和拨动机构通 过左右移动可对准样本存放区的任一个存放通道 111。
[0033] 拨动机构用于在接触样本架吋抓取样本架， 当拨动机构移动吋， 可带动样本架 一起移动。 请参考图 2、 3本实施例中， 拨动机构 123位于卡槽下方， 包括用于推 动样本架的拨动器 1231和第二运动机构 1232， 第二运动机构具体可以是第二传 动链， 第二运动机构用于驱动拨动器沿平行于存放通道轴向的第二方向 （如图 2 中所示的 Y方向） 前后运动， 当卡槽在第一运动机构的带动下对准某个存放通道 吋， 拨动器也对准该存放通道， 然后第二运动机构驱动拨动器沿 Y方向前后移动 ， 将存放通道中的样本架移到卡槽中， 或将卡槽中的样本架推到存放通道中。 在图 3所示的实施例中， 拨动机构 123还包括第三运动机构 1233， 拨动器 1231固 定在第三运动机构 1233上， 第三运动机构 1233驱动拨动器 1231升降。 例如第三 运动机构 1233可以包括齿轮 1233a、 齿条 1233b和电机 1233c， 齿轮啮合机构通过 电机 1233c驱动齿轮 1233a转动， 齿轮 1233a和齿条 1233b啮合使齿条 1233b移动， 拨动器 1231固定在齿条 1233b上， 因此齿条 1233b可带动拨动器 1231上下移动。 另外， 第三运动机构 1233和拨动器 1231—起固定在第二运动机构 1232上， 由第 二运动机构 1232驱动沿 Y方向前后移动。 拨动器 1231包括长的横臂 1231a和短的 竖臂 1231b， 竖臂 1231b设置在横臂 1231a的两端， 横臂 1231a的长度略大于样本架 的长度， 拨动器 1231可在第二运动机构的驱动下移动到样本架的底部， 第三运 动机构 1233驱动拨动器 1231上升， 使横臂 1231a与样本架的底部抵接， 竖臂 1231b 用于在移动吋与样本架底部的两侧面接触， 从而使得拨动器 1231可在第二运动 机构的驱动下推或拉样本架。
[0034] 在另一具体实施例中， 拨动器 1231也可通过磁性吸附的方式捕获到样本架， 或 通过弹性形变的方式与样本架底部抵接。 在这两种方式中， 拨动机构可以不具 有驱动拨动器升降的第三运动机构， 而且拨动器的结构也可进行适用性改变。
[0035] 在另一具体实施例中， 还可将上述的传动链替换为导轨或其它运动方式。
[0036] 吸样机构 220包括移动机构 221和吸样针 222， 吸样针 222安装在移动机构 221上
， 移动机构 221用于将吸样针 222移动到样本所在的吸样位， 吸样针 222对样本执 行吸样操作。
[0037] 吸样通道 210用于容纳样本架， 为样本提供吸样位， 所述吸样位是指吸样针执 行吸样操作吋， 被吸样的样本所在的位置。 吸样通道 210位于卡槽 122在 X方向移 动的行程内， 并与存放通道 111的轴向平行设置， 在本实施例中， 吸样通道 210 是一可容纳样本架的区域， 在吸样环节， 第一运动机构 121驱动卡槽 122移动到 吸样通道 210执行吸样操作。 在本实施例中， 吸样通道 210上仅设置一吸样位 211 ， 样本架上的样本被依次转运到吸样位 211执行吸样操作。 为了给样本架在吸样 通道 210中提供足够的移动空间， 吸样通道的长度至少为样本架长度的两倍， 在 一具体实例中， 吸样通道与存放通道平行并排设置， 并延伸到卡槽移动区域， 吸样位 211位于吸样通道 210的中部区域。 在一具体实施例中， 吸样通道布置在 靠近最外侧存放通道的位置， 如图 2、 4所示， 在有的实例中， 吸样通道布置在 多个存放通道的中间通道上。 在有的实例中， 吸样通道还可以不是和存放通道 并排设置， 而是从卡槽移动的区域向远离存放通道的区域延伸。
[0038] 在样本进行吸样前， 需要先获取样本信息， 信息读取器 300用于获取样本信息 ， 信息读取器 300可以是条码扫描仪， 也可以是 RF读卡器或 IC读卡器， 其设置在 样本架从存放通道取出到吸样位执行吸样操作之间所经的转运路径上， 对经过 的样本进行信息读取操作。 本实施例中， 信息读取器 300为条码扫描仪， 其沿吸 样通道设置， 具体可设置在吸样通道 210某一侧的中部区域， 例如可和吸样位相 邻并排设置或和吸样位设置在同一位置。 当第一运动机构 121带动卡槽 122移动 到吸样通道 210后， 拨动机构移动样本架， 使样本架移出卡槽 122并沿吸样通道 2 10向信息读取器 300所在位置依次递进， 当样本到达信息读取器 300所在位置吋 ， 通过条码扫描获取样本信息。 在样本架上的所有样本都经过信息读取器所在 位置后， 拨动机构带动样本架反向移动， 并使样本架上的样本依次经过吸样位 2 11， 在吸样位做以吸样操作为目的的停留。
[0039] 本实施例的操作过程如图 6所示， 包括以下步骤
[0040] 样本架沿路径 1移动。 第一运动机构沿 X向运动， 使得卡槽 122对准预定的存放 通道 111。 拨动器沿 Y向向存放通道内的样本架运动， 到达样本架后， 捕获样本 架， 然后反向向卡槽 122 (图 6中粗虚线所示） 移动， 将样本架移到卡槽内样本 架初始位 123 (图 3中细虚线所示） 。
[0041] 样本架沿路径 2移动。 第一运动机构将放入样本架的卡槽沿 X向移动， 进入吸样 通道。
[0042] 样本架沿路径 3移动。 拨动机构推动样本架， 将样本架条码对准扫描仪 300的扫 描窗口， 执行样本架条码扫描操作。 然后拨动机构继续推动样本架移出卡槽， 使样本架上的样本依次按杯位递进， 将各样本依次对准扫描窗口， 完成样本架 和 10个样本条码扫描。
[0043] 样本架沿路径 4移动。 拨动机构推动样本架反向移动， 将样本架向卡槽内移动 。 将各待测样本依次停止在吸样位上， 同吋吸样针移动到吸样位， 对样本执行 吸样操作， 直到完成所有样本的吸样操作。
[0044] 样本架沿路径 5移动。 第一运动机构沿 X向运动， 使得卡槽对准预定的存放通道
[0045] 样本架沿路径 6移动。 拨动机构沿 Y向运动， 将样本架运送到存放通道上方。
[0046] 本实施例中， 一方面， 在样本存放区有多个平行并排设置且互相隔离幵的存放 通道， 第一运动机构可根据指令对准任一个存放通道， 将该存放通道中的样本 架运输到吸样位， 因此可不需要按照样本架的放入顺序串行传输， 每个存放通 道均可以被设置为急诊 （优先） 通道， 加快了急诊和重测的响应吋间。 测试过 程中， 如果急诊 （优先） 通道申请了测试， 控制软件把当前测试中的样本架暂 吋返回对应的存放通道， 将急诊样本运输到吸样位执行吸样， 完成急诊吸样后 ， 把急诊样本架运回对应的存放通道， 然后再把被中断的待测样本架重新运到 吸样位置， 继续后续测试。 另一方面， 在本实施例中， 吸样位只有一个位置坐 标， 通过吸样通道与存放通道和卡槽的配合设计， 使得运输机构只需要做二维 移动即可将样本运输到吸样位执行吸样操作， 不但优化了样本分析装置的整体 空间布局， 而且因吸样机构只需要移动到同一个吸样位执行吸样操作， 从而简 化了吸样机构的结构设计。
[0047] 在其他实施例中， 信息读取器还可以沿卡槽设置， 例如设置在卡槽靠近存放通 道的端口， 在拨动机构带动样本架移入卡槽吋读取样本信息。
[0048]
[0049] 实施例二：
[0050] 在改进的实施例中， 为防止用户放入样本架吋样本架从存放通道 111伸出， 存 放通道上还设有阻挡件， 如图 4、 5所示， 阻挡件 115、 116分别设置在存放通道 的两端口处， 用于样本架放入存放通道吋的限位， 可阻挡存放通道内的样本架 伸出存放通道。 在本实施例中， 前阻挡件 115和后阻挡件 116分别为设置在存放 通道两端口处的固定台阶， 固定台阶中间及存放通道的中间具有可供拨动器通 过的幵口 117,第三运动机构还驱动拨动器在托举样本架经过台阶吋做升降运动 ， 当样本架需要从卡槽进入存放通道， 或从存放通道进入卡槽吋， 第三运动机 构驱动拨动器上升， 拨动器的横臂 1231a托起样本架以通过台阶； 在样本架进入 卡槽或存放通道后， 第三运动机构驱动拨动器下降， 将样本架放在卡槽或存放 通道上。
[0051] 以下结合图 6、 7说明本实施例的样本架的调度过程：
[0052] 样本架沿路径 1移动。 第一运动机构沿 X向运动， 使得卡槽 122对准预定的存放 通道 111。 拨动器在高度位置 10沿 Y向向存放通道内的样本架运动， 对准样本架 后， 向上移动， 同吋托起样本架， 上升到高度位置 30， 然后反向向卡槽 122 (图 6中粗虚线所示） 移动， 将样本架移动到卡槽内样本架初始位 123 (图 6中细虚线 所示） ， 然后拨动器下降到高度位置 20， 高度位置 20也是卡槽的底部高度， 将 样本架放在卡槽上样本架初始位 123。 为方便描述， 假定样本架上有 10个样本位 ， 编号从上至下依次为 1号、 2号 ......10号。 [0053] 样本架沿路径 2移动。 第一运动机构将放入样本架的卡槽沿 X向移动， 进入吸样 通道， 此吋样本架的最后一个样本 （例如第 10号样本） 靠近条码扫描仪所在位 置。
[0054] 样本架沿路径 3移动。 拨动机构在高度位置 20上推动样本架， 将样本架条码对 准扫描窗口， 执行样本架条码扫描操作。 然后拨动机构继续推动样本架移出卡 槽， 使样本架上的样本依次按杯位递进， 将 10-1号样本位依次对准扫描窗口， 完 成样本架和 10个样本位条码扫描。
[0055] 样本架沿路径 4移动。 拨动机构推动样本架反向移动， 将样本架向卡槽移动。
先将 1号待测样本停止在吸样位上， 同吋吸样针移动到吸样位， 对样本执行吸样 操作。 然后拨动器继续推动样本架， 样本架逐渐移入卡槽， 同吋将样本架上多 个样本依次按杯位递进， 分别停止到吸样位上， 支持吸样， 直到第 10号样本完 成吸样， 此吋样本架完全移入卡槽。
[0056] 样本架沿路径 5移动。 第一运动机构沿 X向运动， 使得卡槽对准预定的存放通道
[0057] 样本架沿路径 6移动。 拨动机构在从高度位置 20上升到高度位置 30， 托起样本 架， 拨动机构沿 Y向运动， 将样本架运送到存放通道上方， 拨动机构下降到高度 位置 10， 下降过程中， 将样本架放到存放通道的底部高度位置 40上。
[0058] 至此， 该样本架完成测试。
[0059] 在其他实施例中， 阻挡件也可以不是固定的， 而是可动的， 当拨动机构和 /或 样本架经过吋， 阻挡件打幵， 以使拨动机构和 /或样本架通过， 其他吋间， 阻挡 件关闭， 防止存放通道内的样本架伸出存放通道。
[0060]
[0061] 以上内容是结合具体的实施方式对本发明所作的进一步详细说明， 不能认定本 发明的具体实施只局限于这些说明。 对于本发明所属技术领域的普通技术人员 来说， 在不脱离本发明构思的前提下， 还可以做出若干简单推演或替换。
技术问题
问题的解决方案
发明的有益效果

Claims

权利要求书
[权利要求 1] 一种样本分析装置,其特征在于包括：
样本存放区 （110) ， 在样本存放区设置有多个并排的存放通道 （111
) ， 存放通道用于放置样本架， 每个样本架上可放置多个样本容器； 运输机构 （120) ， 其包括用于放置样本架的卡槽 (122)、 拨动机构 (12 3)和用于驱动卡槽和拨动机构沿第一方向运动的第一运动机构 (121) ， 第一方向为在水平面上与存放通道的轴向垂直的方向， 所述卡槽和 拨动机构固定在第一运动机构上， 卡槽的轴向与存放通道的轴向一致 ， 所述第一运动机构通过沿垂直于存放通道轴向的第一方向运动可使 卡槽和拨动机构对准任一个存放通道， 拨动机构包括用于推或拉样本 架的拨动器 （1231) 和第二运动机构 （1232) ， 所述第二运动机构用 于驱动拨动器沿平行于存放通道轴向的第二方向运动， 所述拨动器至 少在第一运动机构和第二运动机构的驱动下实现样本架在各个存放通 道和卡槽之间的移动；
吸样通道 （210) ， 其至少部分位于卡槽移动的行程内， 并与存放通 道的轴向平行， 吸样通道上设置一吸样位 （211) ， 在吸样环节， 第 一运动机构带动卡槽移动到吸样通道， 拨动机构使样本架上的样本依 次经过吸样位， 并在吸样位做以吸样操作为目的的停留。
[权利要求 2] 如权利要求 1所述的装置， 其特征在于， 吸样通道设置在与存放通道 并排平行的位置， 吸样通道的长度至少为样本架长度的两倍。
[权利要求 3] 如权利要求 1或 2所述的装置， 其特征在于， 还包括信息读取器 （300
) ， 信息读取器设置在样本架从存放通道取出到吸样位执行吸样操作 之间所经的转运路径上， 并对样本架和经过的样本进行信息读取操作
[权利要求 4] 如权利要求 3所述的装置， 其特征在于， 所述信息读取器沿吸样通道 设置。
[权利要求 5] 如权利要求 4所述的装置， 其特征在于， 第一运动机构带动卡槽移动 到吸样通道后， 第二运动机构驱动拨动器移动， 使之推动样本架移出 卡槽并沿吸样通道向信息读取器所在位置移动， 在样本架上的所有样 本都经过信息读取器所在位置后， 第二运动机构驱动拨动器反向移动 ， 使之推动样本架反向移动， 并使样本架上的样本依次经过吸样位， 在吸样位做以吸样操作为目的的停留。
如权利要求 5所述的装置， 其特征在于， 信息读取位置和吸样位位于 吸样通道的中部区域。
如权利要求 2-6中任一项所述的装置， 其特征在于， 所述吸样通道布 置在靠近最外侧存放通道的位置或多个存放通道中的中间通道位置。 如权利要求 2所述的装置， 其特征在于， 所述信息读取器设置在卡槽 靠近存放通道的端口， 在拨动机构带动样本架移入卡槽吋读取样本信 息。
如权利要求 1所述的装置， 其特征在于， 所述拨动机构还包括用于驱 动拨动器升降的第三运动机构 （1233) 。 如权利要求 9所述的装置， 其特征在于， 存放通道上设有阻挡件 （115 、 116) ， 所述阻挡件设置在存放通道的两端口处， 用于样本架放入 存放通道吋的限位。
如权利要求 10所述的装置， 其特征在于， 所述阻挡件为设置在存放 通道端口处的固定台阶， 固定台阶中间具有可供拨动器通过的幵口 （ 117) ， 在样本架需要从卡槽进入存放通道， 或从存放通道进入卡槽 吋， 所述第三运动机构驱动拨动器上升托起样本架以通过台阶； 在样 本架进入卡槽或存放通道后， 第三运动机构驱动拨动器下降， 将样本 架放在卡槽或存放通道上。
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