WO2016186335A2 - 상백피추출물과 화살나무추출물을 유효성분으로 포함하는 충치 예방 및 치료용 구강조성물 - Google Patents
상백피추출물과 화살나무추출물을 유효성분으로 포함하는 충치 예방 및 치료용 구강조성물 Download PDFInfo
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- WO2016186335A2 WO2016186335A2 PCT/KR2016/004410 KR2016004410W WO2016186335A2 WO 2016186335 A2 WO2016186335 A2 WO 2016186335A2 KR 2016004410 W KR2016004410 W KR 2016004410W WO 2016186335 A2 WO2016186335 A2 WO 2016186335A2
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- Prior art keywords
- extract
- prevention
- oral composition
- caries
- treatment
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- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- URLJMZWTXZTZRR-UHFFFAOYSA-N sodium myristyl sulfate Chemical compound CCCCCCCCCCCCCCOS(O)(=O)=O URLJMZWTXZTZRR-UHFFFAOYSA-N 0.000 description 1
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- XJPBRODHZKDRCB-UHFFFAOYSA-N trans-alpha-ocimene Natural products CC(=C)CCC=C(C)C=C XJPBRODHZKDRCB-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
Definitions
- the present invention relates to an oral composition for preventing and treating tooth decay, which includes cedar extract and arrow extract as an active ingredient, and more specifically, an extract of cedar extract and an arrow extract showing an excellent effect on caries prevention, improvement and treatment. It relates to an oral composition comprising.
- the oral microorganisms produce toxins in the plaque, and the toxins they produce are periodontal disease when they invade the periodontal tissue and cause inflammation of the gingiva, destruction of the alveolar bone, and infection, and when these bacteria produce acid, the dental caries It can also be a cause.
- microorganisms distributed in the oral cavity cause decay, tooth decay, and periodontal disease, and some of these microorganisms are known as opportunistic pathogens and have the potential to develop diseases.
- Streptococcus mutans and Porphyromonas porphyromonas gingivalis is known to be the main pathogen causing tooth decay and periodontitis.
- Oral pathogenic microorganisms produce glucose and fructose based on sucrose in food by secreting an enzyme called Glucosyltransferase (GTase) from extracellular or surface.
- GTase Glucosyltransferase
- insoluble glucan a polymer of glucose, forms on the tooth surface.
- the glucan forms a bacterial membrane, that is, dental plaque.
- the lactic acid bacteria proliferate in the plaque produced lactic acid to paroxetine lactose as a carbon source, and the adherent glucans lactic acid is collected and concentrated on, thus the concentrated high-concentration acid is tooth and of the calcium phosphate composition of the dental Ca unloaded melt 2 + Tooth decay by dissolving the enamel (enamel) of the outer membrane.
- Korean Patent Publication No. 10-2012-0022423 composition for oral hygiene comprising the seaweed extract as an active ingredient
- Korean Patent Publication No. 10-2008-0113504 Garnier Berry Extract as an active ingredient Containing oral bacterium inhibiting composition
- Morus bark is Morus alba L.) or the root bark of the same plant has long been used in herbal medicine as an anti-inflammatory diuretic, laxative and antitussive expectorant.
- the winged spindle is the arrow tree (the Euonymus).
- alatus (Thunb.) Sieb.) is a deciduous shrub to the lone tree, Nova vines and is distributed in Korea, Japan, Sakhalin and China.
- Young leaves are herbs and the wings of branches are called earheads.
- the leaves contain epipriedelanol, priedelin, quercetin and dulcitol.
- Seed oil contains saturated fatty acids (20%), oleic acid, linoleic acid, linolenic acid, capric acid and benzoic acid. Oriental medicine is used for hemostasis, gore blood, pain.
- the present inventors have completed the present invention by confirming the efficacy using the baekbaekpi and arrowwood showing the above-described efficacy in order to develop a drug exhibiting an excellent antimicrobial effect against the causative agent.
- An object of the present invention is to provide an oral composition for preventing and treating tooth decay, including the extract of cedar extract and arrow extract as an active ingredient.
- Oral composition for preventing or treating tooth decay or tooth decay prevention and improvement of the health functional food of the present invention to achieve the above object is characterized by showing the growth inhibitory activity of the tooth decay-derived and arrow extract as an active ingredient, caries-inducing bacteria to be.
- the caries-inducing bacteria are characterized as Streptococcus mutans ( Streptococcus mutans ).
- the cedar extract and arrowwood extract is characterized by consisting of 1: 1 weight ratio.
- the lettuce extract or arrow extract is characterized in that extracted with ethanol.
- the oral composition is characterized by having any one or more formulations selected from toothpaste, chewing gum, mouthwash, mouthwash and mouth spray.
- the health functional food is characterized by having any one or more formulations selected from powders, granules, tablets, capsules or beverages.
- an oral composition or a health functional food including an extract of cedar extract and arrowwood extract as an active ingredient, and having an excellent effect on the prevention, improvement and treatment of caries is provided.
- an extract of cedar extract and arrowwood extract as an active ingredient, and having an excellent effect on the prevention, improvement and treatment of caries.
- 1 is a graph showing the antimicrobial activity of lettuce extract.
- Figure 2 is a graph showing the antimicrobial activity of arrowwood extract.
- 3 and 4 is a graph showing the antimicrobial activity of the mixed extract consisting of lettuce extract + arrowroot extract.
- the present invention provides an oral composition for preventing and treating tooth decay, including the extract of cedar and arrowwood extract as an active ingredient.
- the baekpipi extract or arrowwood extract is dried by extracting the baekpipi or arrowwood, respectively, 5 to 15 times the solvent of each weight (g), preferably water, lower alcohol of C1 to C4 or a mixed solvent thereof Extracts soluble in a solvent selected from, more preferably 1 to 10 times, preferably 3 to 10 hours at 10 to 50 ° C, preferably 20 to 30 ° C, preferably 3 to 36 hours with ethanol Can be obtained by repeated extraction five times.
- the extract of cedar extract and arrowwood extract were found to exhibit antimicrobial activity against caries-inducing bacteria only when the extract was used as an active ingredient in a high concentration of 100 to 1000 ppm or more.
- the stability of the active ingredient will also be able to obtain the prevention and treatment of caries disease.
- the extract of the cedar extract and the arrowwood extract in a 1: 1 weight ratio and use it as an effective ingredient for oral composition for caries prevention and treatment.
- the bacteria causing tooth decay it exhibits antimicrobial activity against Streptococcus mutans .
- the oral composition containing the extract of the present invention may be prepared by using a formulation such as toothpaste, chewing gum, mouthwash, mouthwash and mouth spray, but is not limited thereto.
- Toothpaste of the present invention comprises a composition selected from the group consisting of abrasives, binders, moisturizers, active ingredients, foaming agents, sweeteners, flavoring agents.
- Abrasives include aluminum hydroxide, silicic anhydride, aluminum silicate, dibasic calcium phosphate, dihydrate and anhydride, tricalcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate and calcium sulfate , Polymethyl methacrylate, and other synthetic resins may be used in combination of one or two or more of them in an amount of about 20-90% of the total composition (20-60% in the case of paste toothpaste).
- synthetic polymers such as a garginine, various cellulose derivatives for thickening, gums, such as a xanthan gum and a tragacanth gum, polyvinyl alcohol, sodium polyacrylate, a polyacrylic acid / maleic acid copolymer, and carboxyvinyl polymer
- organic binders such as derivatives
- inorganic binders such as a silica and a laponite, 1 type, or 2 or more types can be mix
- Paste and liquid oral compositions in dentifrices include sorbitol, glycerin, ethylene glycol, propylene glycol, polyether glycol, polypropylene glycol, and the like as moisturizing agents in the preparation of about 10-70% of the total composition. It can be used in combination.
- oral compositions containing the extract of the present invention include menthol (Mentol), anetol (Anetol), eugenol (Eugenol), limonene (Limonene), Ocimene, n-dodecyl alcohol (n-Dodecy Alcohol, Citronenol, Alpha-Terpineol, Methyl salycilate, Methyl Acetate, Citroneryl Acetate, Cineol, Linalol, Ethyl Linalool, Vanillin, Thymol, Spearamint Oil, Sage Oil, Rosemary Oil, Cinnamon Oil, etc.
- the agents may be used alone or in combination in amounts of 0.1-10%, preferably 0.5-5%, of the total composition.
- sweeteners such as sodium saccharin, stevioside, aspartame, D-Xylose and the like can be used in combination in an amount of 0-1%, preferably 0.01-0.5% of the total composition.
- oral compositions of the present invention include trichloric acid, chlorohexidine, benzetonium chloride, benzalkonium chloride, cationic fungicides such as cetylpyridium chloride, alkali metal monofluoro such as sodium monofluorophosphate and potassium monophosphate, etc.
- Fluorides such as phosphate, sodium fluoride and tin fluoride, tranexamic acid, epsilon amino capronic acid, aluminum chlorohydroxy allantoin, dihydro cholestanol, cletylithic acid, glycerophosphate, sodium chloride, and water-soluble inorganic phosphate compounds
- one or two or more of various potent ingredients such as ascorbic acid (sodium), dl-a-tocopherol acetate, xylitol, pyridoxine hydrochloride and polyvinyl pyrrolidone can be used in combination.
- the surfactant used as the foaming component in the oral composition of the present invention may be used anionic surfactants, nonionic surfactants and / or zwitterionic surfactants.
- the anionic surfactants include sodium lauryl sulfate, sodium alkyl sulfates such as myristyl sulfate, sodium N-Lauroyl sarcosinate, sodium N-miristyl sarcosinate, and the like.
- Sodium N-acyl sarcosinate may be used
- non-ionic surfactants include sugar-derived fatty acid esters such as sugar fatty acid esters, maltose fatty acid esters, lactose fatty acid esters, and polyesters.
- Oxy ethylene hardened castor oil, polyoxyethylene higher alcohol ether, polyoxy ethylene polyoxy propylene copolymer, polyoxy ethylene polypropylene fatty acid ester and the like can be used.
- Zwitterionic surfactants include N-alkyl diaminoethylglycine, such as N-lauryl di aminoethylglycine, N-myristyl diaminoethylglycine, N-alkyl-N-carboxy methyl ammonium betaine, 2-alkyl-1 -Hydroxy ethyl imidazoline betaine sodium, etc. can be used.
- anionic surfactants are mainly used as the foaming component, and sodium alkyl sulfates such as sodium lauryl sulfate are most widely used.
- these surfactant is used individually by 1 type or in mixture of 2 or more types, and the compounding quantity normally uses 0.01-0.5% of a whole composition, More preferably, 0.05-0.3%.
- the present invention provides a health functional food for the prevention and improvement of tooth decay containing the extract as an active ingredient.
- Health functional foods containing the extract of the present invention can be used in a variety of drugs, foods and drinks for the prevention and improvement of tooth decay.
- Foods to which the extract of the present invention may be added include, for example, various foods, beverages, gums, teas, vitamin complexes, health supplements, and the like, and may be used in the form of powders, granules, tablets, capsules, or beverages. have.
- the extract itself of the present invention has little toxicity and side effects, it is a drug that can be used safely even when taken for long periods of time.
- the extract of the present invention may be added to food or beverage for the purpose of preventing and improving tooth decay.
- the amount of the extract in the food or beverage is generally the health food composition of the present invention can be added to 0.01 to 15% by weight of the total food weight, the health beverage composition is 0.02 to 10 g, preferably based on 100 ml It can be added at a ratio of 0.3 to 1 g.
- the health beverage composition of the present invention in addition to containing the extract or compound as an essential ingredient in the indicated ratio, there is no particular limitation on the liquid component, and may contain various flavors or natural carbohydrates as additional ingredients, such as ordinary drinks.
- natural carbohydrates are conventional monosaccharides such as disaccharides such as glucose and fructose, such as maltose, sucrose and the like, and polysaccharides such as dextrin, cyclodextrin and the like.
- Sugars and sugar alcohols such as xylitol, sorbitol, and erythritol.
- natural flavoring agents such as, tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used.
- the proportion of natural carbohydrates is generally about 1-20 g, preferably about 5-12 g per 100 ml of the composition of the present invention.
- the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and its Salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated drinks, and the like.
- the health functional food of the present invention may contain natural fruit juice and fruit flesh for producing fruit juice beverages and vegetable beverages. These components can be used independently or in combination. The proportion of such additives is not so critical but is generally selected in the range of 0 to about 20 parts by weight per 100 parts by weight of the composition of the present invention.
- the powder was ground in a grinder, and then 1 kg of the baekbaekpi powder was placed in 10 l of 70% ethanol and refluxed at room temperature for 3 hours, and the extract was repeated three times.
- the extract was filtered to recover only the extract filtrate, and then distilled under reduced pressure to prepare a liquid extract extract (receiving concentration: 10000 ppm).
- the prepared lettuce extract was diluted by 10 times step by step using sterile distilled water was prepared by concentration (0.1, 1, 10, 100, 1000, 10000 ppm).
- the arrow branches were washed with purified water and then naturally dried at room temperature for 7 days.
- the powder was ground with a grinder, and 1 kg of the arrowwood powder was added to 10 l of 70% ethanol, and refluxed at room temperature for 3 hours, and the extract was repeated three times.
- the extract was filtered to recover only the extract filtrate and distilled under reduced pressure to prepare a liquid arrow extract (receiving concentration: 10000 ppm).
- the manufactured arrow extract was diluted by 10 times step by step using sterile distilled water was prepared by concentration (0.1, 1, 10, 100, 1000, 10000 ppm).
- Cereal extract prepared from the above and b. Prepared by the same concentration of arrowwood extract prepared in the mixed extract was prepared in a 1: 1 weight ratio.
- MIC tests were performed to determine the antimicrobial activity of the extracts from the extracts of cedar and arrowwood.
- the strain used was the Streptococcus mutans KCTC 3065 strain, which is a caries-inducing bacterium distributed from the Korea Research Institute of Bioscience and Biotechnology (Korea Collection for Type Cultures, KCTC).
- Streptococcus mutans KCTC 3065 strain which was the cavities-induced bacterium, was inoculated in Brain heart infusion broth medium and then cultured at 37 ° C.
- the mixed solution was prepared by mixing 4.45 ml of sterilized liquid medium, 0.5 ml of extract (10%, V / V), and 0.05 ml of bacterial culture solution at a concentration of 10 6 cfu / ml in a test tube so that the final mixture was 5 ml.
- the diluted solution was diluted 10 times step by step using the stock solution and sterile distilled water.
- test tube containing the mixed solution of 1, including the bacterial culture solution, the extract and the sterilized liquid medium, was incubated at 37 ° C. for 30 hours.
- Antibiotic determination was carried out every 3 hours of culture, 0.1 ml of the mixed solution of each treatment was measured using a 96 well palte to measure the change in absorbance due to bacterial growth at 600 nm.
- Figure 1 was tested for the antimicrobial activity of the extract from the extract of the extract from the Streptococcus mutans KCTC 3065 strain, it was confirmed that the antimicrobial activity at the low concentration of 10 ppm, the antimicrobial activity was slightly weak at 50 ppm.
- Figure 2 was tested for the antimicrobial activity of the arrowwood extract in Streptococcus mutans KCTC 3065 strains, it was confirmed that the antimicrobial activity in the low concentration of all 10 ppm, 50 ppm showed little.
- composition for preventing and treating periodontal disease prepared according to the present invention when using the composition for preventing and treating periodontal disease prepared according to the present invention, it is expected to exhibit an excellent antimicrobial activity against the strain causing the periodontal disease, it is possible to obtain the effect of preventing and treating periodontal disease, thereby As it can be used as a material for food, medicine, etc., it is expected to increase the value added.
- the components belonging to a of Table 1 were added to the production unit at a temperature of 70 to 75 ° C., and stirred for 20 minutes to completely dissolve the powder and then cooled to room temperature.
- the components belonging to b including the carrier obtained in Example 1 were added to the production unit at 25 to 30 ° C., followed by stirring for 15 minutes to dissolve.
- the components belonging to c were mixed at 25 to 35 ° C. and added in stages.
- the next process was a foaming agent mixing and primary degassing process, in which the components belonging to d were added to complete the primary defoaming during the 40 minute process at 25 to 35 ° C.
- the final process is a fragrance mixing process, to which toothpaste was prepared by adding a component belonging to e and degassing at 25 to 35 ° C.
- composition was according to Table 1 below.
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Abstract
본 발명은 상백피추출물과 화살나무추출물을 유효성분으로 포함하는 충치 예방 및 치료용 구강조성물에 관한 것으로서, 보다 상세하게는 충치 예방, 개선 및 치료에 우수한 효과를 나타내는 상백피추출물과 화살나무추출물을 유효성분으로 포함하는 구강조성물에 관한 것이다. 본 발명에 의해, 충치 예방, 개선 및 치료에 우수한 효과를 나타내는 구강조성물 또는 건강기능식품이 제공된다.
Description
본 발명은 상백피추출물과 화살나무추출물을 유효성분으로 포함하는 충치 예방 및 치료용 구강조성물에 관한 것으로서, 보다 상세하게는 충치 예방, 개선 및 치료에 우수한 효과를 나타내는 상백피추출물과 화살나무추출물을 유효성분으로 포함하는 구강조성물에 관한 것이다.
사람의 구강 내에는 여러 종류의 미생물들이 살고 있으며, 구강질환을 일으키는 구강미생물은 대부분 치아와 잇몸 사이에 형성되는 세균막인 프라그에 존재하는 것으로 알려져 있다.
상기 구강미생물들은 프라그에서 독소를 생성하고 이들이 생산한 독소는 치주조직 내로 침입하여 치은의 염증, 치조골의 파괴 및 감염을 일으키면 치주병이 되며, 이들 세균이 산(酸)을 생성하면, 치아우식증이 원인이 되기도 한다.
이와 같이 구강 내에 분포하는 미생물들은 구치, 충치, 및 치주질환 등을 유발하며, 이들 미생물들의 일부는 기회성 병원체로서 질병 발병의 가능성을 가지고 있는 것으로 알려져 있다.
구강 내에 상재하면서 충치와 치주염 발생시키는 병원성 미생물로 여러 종들이 알려져 있으나, 그 중 스트렙토코커스 뮤탄스(Streptococcus mutans)와 포피로모나스 진지바리스(Porphyromonas
gingivalis)가 충치와 치주염을 발생하는 주 병원체인 것으로 알려져 있다.
구강 내 병원성 미생물은 균체 외 또는 표면으로부터 글루코실 트랜스퍼라아제(Glucosyltransferase, GTase)라는 효소를 분비함으로써 음식물 내 수쿠로즈(sucrose)를 기질로 하여 글루코즈(glucose)와 프락토즈(fructose)를 생성하고, 동시에 글루코즈의 중합체인 불용성 글루칸(insoluble glucan)을 치면에 형성하게 된다. 형성된 글루칸에 다른 미생물들이 치면에 부착하므로써 치면 세균막 즉, 치태(dental plaque)를 형성하게 된다. 이 치태 내에서 젖산균이 증식하여 프락토즈를 탄소원으로 젖산을 생성하고, 부착성 글루칸에 젖산이 포집 농축되고, 이렇게 농축된 고농도의 산은 치아의 구성성분인 인산칼슘 중 Ca2
+를 녹아 내리게 하여 치아의 외막인 법랑질(enamel)을 용해시킴으로써 충치를 유발하게 된다.
따라서, 최근에는 구강 미생물을 효과적으로 억제할 수 있는 다양한 약물들이 개발되고 있으며, 이들을 적용한 구강 위생 제품이 다양하게 개발되고 있다.
관련 선행기술로는 대한민국공개특허 제10-2012-0022423호 "바다제비집 추출물을 유효성분으로 포함하는 구강위생 증진용 조성물"과 대한민국공개특허 제10-2008-0113504호 "인삼열매 추출물을 유효성분으로 함유하는 구강세균 억제용 조성물" 등이 있다.
상백피는 뽕나무(Morus
alba
L.) 또는 동속식물의 뿌리껍질로서 오래전부터 소염성 이뇨제, 완화제 및 진해거담제로 한방 약제에 사용되어 왔다.
최근 들어 이들 상백피에 함유된 각종 성분들이 점차 밝혀지고 그 약리 효과도 규명되고 있는데 특히 혈압 강하작용, 혈당 강하작용 및 진통 작용이 널리 알려져 있다.
화살나무(winged spindle)는 화살나무(참빗나무, Euonymus
alatus (Thunb.) Sieb.)는 무환자나무목 노박덩굴과의 낙엽관목으로, 한국, 일본, 사할린, 중국 지역에 분포한다. 어린잎은 나물로 하고 가지의 날개를 귀전우(鬼剪羽)라고 한다. 잎에는 에피프리에델라놀(epifriedelanol), 프리에델린(friedelin), 퀘르세틴(quercetin), 둘시톨(dulcitol)이 함유되어있다. 종자유에는 포화지방산(20%), 올레인산, 리놀산, 리놀렌산, 카프릭산 및 안식향산 등이 함유되어 있다. 한방에서는 지혈, 구어혈, 통경에 사용한다.
이에 본 발명자들은 충치원인균에 대한 탁월한 항균효과를 나타내는 약물을 개발하기 위해서 상기와 같은 효능을 나타내는 상백피와 화살나무를 사용하여 그 효능을 확인함으로써 본 발명을 완성하게 되었다.
본 발명의 목적은 상백피추출물과 화살나무추출물을 유효성분으로 포함하는 충치 예방 및 치료용 구강조성물을 제공하는데 있다.
본 발명이 이루고자 하는 기술적 과제들은 이상에서 언급한 기술적 과제들로 제한되지 않으며, 언급되지 않은 다른 기술적 과제들은 아래의 기재로부터 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자에게 명확하게 이해될 수 있을 것이다.
상기 목적을 달성하기 위한 본 발명의 충치 예방 및 치료용 구강조성물 또는 충치 예방 및 개선용 건강기능식품은 상백피추출물과 화살나무추출물을 유효성분으로 포함하여, 충치 유발 세균의 성장 억제 활성을 나타내는 것이 특징이다.
*상기 충치 유발 세균은 스트렙토코쿠스 뮤탄스(Streptococcus mutans)인 것이 특징이다.
상기 상백피추출물과 화살나무추출물은 1:1 중량비로 이루어지는 것이 특징이다.
상기 상백피추출물 또는 화살나무추출물은 에탄올로 추출한 것이 특징이다.
상기 구강조성물은 치약류, 츄잉껌, 구강 청정제, 구강 세정제 및 구강 스프레이 중 선택된 어느 하나 이상의 제형을 갖는 것이 특징이다.
상기 건강기능식품은 분말, 과립, 정제, 캡슐 또는 음류 중 선택된 어느 하나 이상의 제형을 갖는 것이 특징이다.
본 발명에 의해, 상백피추출물과 화살나무추출물을 유효성분으로 포함하여, 충치 예방, 개선 및 치료에 우수한 효과를 나타내는 구강조성물 또는 건강기능식품이 제공된다. 이에, 종래의 일반 치약에 비하여 구강용 약효성분의 안정성의 향상과 함께 충치질환의 예방 및 치료효과를 얻을 수 있게 된다.
도 1은 상백피추출물의 항균활성을 나타낸 그래프이다.
도 2는 화살나무추출물의 항균활성을 나타낸 그래프이다.
도 3 및 4는 상백피추출물+화살나무추출물로 이루어진 혼합추출물의 항균활성을 나타낸 그래프이다.
이하, 본 발명을 상세하게 설명하며, 본 발명의 요지를 불필요하게 흐릴 수 있는 공지 기능 및 구성에 대한 상세한 설명은 생략한다.
본 발명은 상백피추출물과 화살나무추출물을 유효성분으로 포함하는 충치 예방 및 치료용 구강조성물을 제공한다.
이때, 상기 상백피추출물 또는 화살나무추출물은 상백피 또는 화살나무를 각각 건조하여 각 무게(g)의 5~15배의 용매로 추출하며, 바람직하게는 물, C1 내지 C4의 저급알코올 또는 이들의 혼합용매로부터 선택된 용매에 가용한 추출물, 더욱 바람직하게는 에탄올로 10 내지 50℃, 바람직하게는 20 내지 30℃에서 1 내지 150 시간, 바람직하게는 3 내지 36시간으로 1 내지 10회, 바람직하게는 3 내지 5회 반복 추출하여 수득할 수 있다.
이렇게 제조된 상기 상백피추출물과 화살나무추출물은 각각을 유효성분으로사용할 경우에는 추출물 상에 100 내지 1000ppm 이상의 고농도로 함유되어야 충치 유발세균에 대한 항균활성을 나타냄을 알 수 있었다. 이에 저농도의 추출물에서도 본 발명이 목적하는 충치 유발 세균에 대한 항균활성을 나타냄으로써 제품화 가능한 조성물을 제조하기 위해서는 상기 상백피추출물과 상기 화살나무추출물 혼합하여 사용하는 것이 좋으며, 종래의 일반 치약에 비하여 구강용 약효성분의 안정성의 향상과 함께 충치질환의 예방 및 치료효과도 얻을 수 있게 되는 것이다.
이때, 본 발명이 목적하는 충치 유발 세균의 가장 우수한 성장 억제 활성을 얻기 위해서는 상기 상백피추출물과 상기 화살나무추출물을 1:1 중량비로 혼합하여 충치 예방 및 치료용 구강조성물의 유효성분으로 사용하는 것이 좋으며, 충치 유발 세균 중에서도 스트렙토코쿠스 뮤탄스(Streptococcus mutans)에 대하여 항균활성을 나타내는 것이 특징이다.
이렇게 본 발명의 추출물을 함유하는 구강조성물은 치약류, 츄잉껌, 구강 청정제, 구강 세정제 및 구강 스프레이 등의 제형으로 제조하여 사용할 수 있으나, 이에 한정하는 것은 아니다.
본 발명의 치약류는 연마제, 점결제, 보습제, 유효성분, 발포제, 감미료, 향미제로 이루어진 군에서 선택된 조성물을 포함한다.
연마제로는 수산화알루미늄, 무수규산, 규산알루미늄, 제2인산칼슘, 제2수산화물 및 무수물, 제3인산칼슘, 탄산칼슘, 피로인산칼슘, 불용성 메타인산나트륨, 제3인산마그네슘, 탄산마그네슘, 황산칼슘, 폴리메타아크릴산메틸, 기타 합성수지 등에서 1종 또는 2종 이상을 전체 조성물의 약 20-90%의 양으로 배합하여 사용할 수있다(페이스트 치약의 경우에는 20-60%가 된다).
점결제로는 가라기닌, 각종 점증용 셀룰로오스 유도체, 잔탄검, 트라가칸트 검(Tragacanth gum) 등의 검류, 폴리비닐 알콜, 폴리아크릴산 나트륨, 폴리아크릴산/말레인산 공중합체, 카르복시비닐 폴리머 등의 합성고분자 유도체 등의 유기계 점결제와 실리카, 라포나이트 등의 무기계 점결제에서 1종 또는 2종 이상을 전체 조성물의 약 0.3-5%의 양으로 배합하여 사용할 수 있다.
치약류 중 페이스트상과 액상 구강용 조성물에서는 그 제조시 보습제로 솔비톨, 글리세린, 에틸렌글리콜, 프로필렌 글리콜, 폴리에테르 글리콜, 폴리프로필렌 글리콜 등에서 1종 또는 2종 이상을 전체 조성물의 약10-70%의 양으로 배합하여 사용할 수 있다.
한편, 본 발명의 추출물을 함유하는 구강조성물에는 맨톨(Mentol), 아네톨(Anetol), 오이게놀(Eugenol), 리모넨(Limonene), 오시멘(Ocimene), n-도데실알콜(n-Dodecy Alcohol), 시트로네놀(Citronenol), 알파터피네올(a-Terpineol), 살리실메틸(Methyl salycilate), 메틸아세테이트(Methyl Acetate), 시트로네릴 아세테이트(Citronelyl Acetate), 시네올(Cineol), 리나롤(Linalool), 에틸리나롤(Ethyl Linalool), 바닐린(Vanillin), 티몰(Thymol), 스피아민트(Speamint)유, 세지(Sage)유, 로즈마리(Rosemary)유, 계피(Cinamon)유 등의 항료를 단독 또는 조합하여 전체 조성물의 0.1-10%, 바람직하게는 0.5-5%의 양으로 배합하여 사용할 수 있다.
또한 사카린나트륨, 스테비오사이드, 아스파탐, D-자일로스(D-Xylose) 등과 같은 감미제 등을 전체 조성물의 0-1%, 바람직하게는 0.01-0.5%의 양으로 배합하여 사용할 수 있다.
또한 본 발명의 구강조성물에는 트리클로산, 클로로 헥시딘, 벤제토늄클로라이드, 벤잘코늄크로라이드, 세틸피리듐 크리라이드과 같은 양이온성 살균제, 모노플로로인산나트륨과 모노플로로 인산칼륨 등과 같은 알카리금속 모노플로로 포스페이트와 불화나트륨, 불화제일주석 등의 불소화물, 트라넥삼산, 입실론 아미노 카프론산, 알루미늄 클로로 하이드록실 알란토인, 디하이드로 콜레스타놀, 클리틸리친산류, 글리세로 포스테이트, 염화나트륨, 수용성 무기인산 화합물, 아스코르빈산(나트륨), 초산 dl-a-토코페롤, 자일리톨, 염산피리독신, 폴리비닐 피롤리돈 등의 각종 효능성분 중 1종 또는 2종 이상을 선택 배합하여 사용할 수 있다.
또한 본 발명의 구강조성물에서 발포성분으로 사용하는 계면활성제로는 음이온 계면활성제, 비이온계면활성제 및/또는 양성이온 계면활성제를 사용할 수 있다. 여기서, 음이온 계면활성제로는 라우릴황산나트륨, 미리스틸황산나트륨 등의 알킬황산나트륨, N-라우로일 사르코신산나트륨(Sodium N-Lauroyl sarcosinate), N-미리스틸 사르코신산나트륨(Sodium N-miristyl sarcosinate) 등의 N-아실 사르로신산 나트륨(Sodium N-acyl sarcosinate) 등을 사용할 수 있고, 비이온 계면활성제로는 슈가지방산 에스테르, 말토스 지방산 에스테르, 락토스 지방산 에스테르 등과 같은 당(糖)유래 지방산 에스테르, 폴리옥시 에틸렌 경화 피마자유, 폴리옥시에틸렌고급알콜 에테르, 폴리옥시 에틸렌 폴리옥시 프로필렌 공중합체, 폴리옥시 에틸렌 폴리프로필렌 지방산 에스테르 등을 사용할 수 있다. 양성이온 계면활성제로는 N-라우릴 디 아미노에틸글리신, N-미리스틸 디아미노에틸글리신 등과 같은 N-알킬 디 아미노에틸글리신, N-알킬-N-카르복시 메틸 암모늄 베타인, 2-알킬-1-하이드록시 에틸 이미다조린 베타인 나트륨 등을 사용할 수 있다. 이 경우 발포성분으로는 음이온 계면활성제를 주로 사용하며 대표적인 것으로는 라우릴 황산나트륨과 같은 알킬황산 나트륨을 가장 널리 사용하고 있다. 또한 이들 계면활성제는 1종 단독 또는 2종 이상 혼합하여 사용하며 배합량은 통상 전체 조성물의 0.01-0.5%, 보다 바람직하게는 0.05-0.3%를 사용한다.
또한, 본 발명은 상기 추출물을 유효성분으로 함유하는 충치의 예방 및 개선용 건강기능식품을 제공한다.
본 발명의 추출물을 포함하는 건강기능식품은 충치의 예방 및 개선을 위한 약제, 식품 및 음료 등에 다양하게 이용될 수 있다. 본 발명의 추출물을 첨가할 수 있는 식품으로는, 예를 들어, 각종 식품류, 음료, 껌, 차, 비타민 복합제, 건강보조 식품류 등이 있고, 분말, 과립, 정제, 캡슐 또는 음료인 형태로 사용할 수 있다.
본 발명의 추출물 자체는 독성 및 부작용은 거의 없으므로 예방 목적으로 장기간 복용 시에도 안심하고 사용할 수 있는 약제이다.
이에, 본 발명의 상기 추출물은 충치의 예방 및 개선을 목적으로 식품 또는 음료에 첨가될 수 있다. 이때, 식품 또는 음료 중의 상기 추출물의 양은 일반적으로 본 발명의 건강식품 조성물은 전체 식품 중량의 0.01 내지 15 중량%로 가할 수 있으며, 건강 음료 조성물은 100 ㎖를 기준으로 0.02 내지 10 g, 바람직하게는 0.3 내지 1 g의 비율로 가할 수 있다.
본 발명의 건강 음료 조성물은 지시된 비율로 필수 성분으로서 상기 추출물 또는 화합물을 함유하는 것 외에 액체성분에는 특별한 제한점은 없으며 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다. 상술한 천연 탄수화물의 예는 모노사카라이드, 예를 들어, 포도당, 과당 등의 디사카라이드, 예를 들어 말토스, 슈크로스 등의 및 폴리사카라이드, 예를 들어 덱스트린, 시클로덱스트린 등과 같은 통상적인 당 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 상술한 것 이외의 향미제로서 천연 향미제(타우마틴, 스테비아 추출물(예를 들어 레바우디오시드 A, 글리시르히진등) 및 합성 향미제(사카린, 아스파르탐 등)를 유리하게 사용할 수 있다. 상기 천연 탄수화물의 비율은 본 발명의 조성물 100 ㎖당 일반적으로 약 1 내지 20g, 바람직하게는 약 5 내지 12g이다.
상기 외에 본 발명의 조성물은 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 중진제(치즈, 초콜릿 등), 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등을 함유할 수 있다. 그밖에 본 발명의 건강기능식품은 천연 과일 쥬스 및 과일 쥬스 음료 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 성분은 독립적으로 또는 조합하여 사용할 수 있다. 이러한 첨가제의 비율은 그렇게 중요하진 않지만 본 발명의 조성물 100 중량부당 0 내지 약 20 중량부의 범위에서 선택되는 것이 일반적이다.
이하에서는 실시예 및 실험예를 들어 본 발명에 관하여 더욱 상세하게 설명할 것이나, 이들 실시예 및 실험예는 단지 설명의 목적을 위한 것으로 본 발명의 보호 범위를 제한하고자 하는 것은 아니다.
<실시예 1> 상백피추출물+화살나무추출물로 이루어진 혼합추출물 제조
가. 상백피추출물 제조
상백피를 정제수로 세척한 후 상온에서 7일간 자연건조하였다.
상기 건조 후 분쇄기로 분말화 한 다음 이 상백피 분말 1kg을 70% 에탄올 10ℓ에 넣고 상온에서 3시간동안 환류추출하였고, 이를 3회 반복하여 추출물을 제조하였다.
상기 추출물을 여과하여 추출 여액만을 회수한 후 감압 증류하여 액상의 상백피추출물(수령 농도: 10000 ppm)을 제조하였다.
이때, 상기 제조된 상백피 추출물은 멸균 증류수를 이용하여 10배씩 단계별로 희석하여 농도별(0.1, 1, 10, 100, 1000, 10000 ppm)로 제조하였다.
나, 화살나무추출물 제조
화살나무 가지를 정제수로 세척한 후 상온에서 7일간 자연건조하였다.
상기 건조 후 분쇄기로 분말화 한 다음 이 화살나무 분말 1kg을 70% 에탄올 10ℓ에 넣고 상온에서 3시간동안 환류추출하였고, 이를 3회 반복하여 추출물을 제조하였다.
상기 추출물을 여과하여 추출 여액만을 회수한 후 감압 증류하여 액상의 화살나무추출물(수령 농도: 10000 ppm)을 제조하였다.
이때, 상기 제조된 화살나무추출물은 멸균 증류수를 이용하여 10배씩 단계별로 희석하여 농도별(0.1, 1, 10, 100, 1000, 10000 ppm)로 제조하였다.
다. 혼합추출물 제조
상기 가. 에서 제조된 상백피추출물과 상기 나. 에서 제조된 화살나무추출물을 같은 농도별로 준비한 후 1:1 중량비로 혼합한 혼합추출물을 제조하였다.
<실험예 1> 항균활성 확인
상백피추출물과 화살나무추출물 그리고 이들의 혼합추출물의 충치균에 대한 항균활성을 측정하기 위하여 MIC(mininal inhibitory concentration) 테스트를 진행하였다.
1. 시험 대상 균주
사용된 균주는 한국생명공학연구원 미생물자원센터(Korea Collection for Type Cultures, KCTC)에서 분양받은 충치유발세균인 스트렙토코커스 뮤탄스(Streptococcus mutans) KCTC 3065 균주를 사용하였다.
2. 시험방법
1) 균주 배양 조건
상기 분양받은 충치유발세균인 스트렙토코커스 뮤탄스(Streptococcus mutans) KCTC 3065 균주를 Brain heart infusion broth배지에 접종한 후 이를 37℃에서 정치배양하였다.
2) 추출물의 처리
① 최종 혼합액이 5 ㎖가 되도록, 멸균된 액체 배지 4.45 ㎖, 추출물 0.5 ㎖ (10%, V/V), 106 cfu/㎖ 농도의 세균 배양액 0.05 ㎖를 시험관에 혼합하여 혼합액을 제조하였다.
② 추출물의 경우 원액과 멸균 증류수를 이용하여 10배씩 단계별로 희석한 희석액을 처리하도록 하였다.
③ 상백피추출물과 화살나무추출물의 혼합 처리구는 각 추출물을 0.25 ㎖씩 넣어주며, 추출물을 처리하지 않는 경우는 0.5 ㎖의 멸균 증류수를 처리하도록 하였다.
3) 배양방법
세균 배양액, 추출물, 멸균된 액체 배지를 포함하는 상기 ①의 혼합액이 담긴 시험관을 37℃에서 30 시간 배양하였다.
항생활성의 판정은 배양 3시간 마다 각 처리구의 혼합액 0.1 ㎖를 취하여 96 well palte를 이용 세균 증식에 의한 흡광도 변화를 600 nm에서 측정하였다.
2. 실험결과
1) 상백피 추출물의 항균활성
도 1은 Streptococcus
mutans KCTC 3065 균주를 대상으로 상백피 추출물의 항균활성을 시험한 것으로서, 저농도인 10 ppm에서는 항균활성이 거의 나타나지 않으며, 50 ppm에서도 항균활성이 다소 약하게 나타남을 확인하였다.
2) 화살나무 추출물의 항균활성
도 2는 Streptococcus
mutans KCTC 3065 균주를 대상으로 화살나무 추출물의 항균활성을 시험한 것으로서, 저농도인 10 ppm, 50 ppm 모두에서 항균활성이 거의 나타나지 않음을 확인하였다.
3) 상백피추출물+화살나무추출물로 이루어진 혼합추출물의 항균활성
도 3 및 4는 Streptococcus
mutans KCTC 3065 균주를 대상으로 상백피추출물+화살나무추출물로 이루어진 혼합추출물의 항균활성을 시험한 것으로서, 혼합추출물을 10~100 ppm 처리시 항균활성을 나타냄을 확인하였다.
구체적으로 비교설명하면, 도 3에 나타나 있듯이, 저농도인 화살나무추출물 5 ppm을 단독처리한 경우(-▲-) 거의 활성을 나타내지 못하였다. 또한, 상백피추출물 5 ppm을 단독처리한 경우(-■-)에도 거의 활성을 나타내지 못한 반면, 본 발명의 유효성분인 1:1 혼합추출액(실시예 1)의 경우 각각 투여한 경우에 비해 항균활성이 상대적으로 높게 나타남을 확인하였다(-◆-).
특히, 도 4에 나타나 있듯이, 화살나무추출물 50 ppm 단독처리(-▲-) 및 상백피추출물 50 ppm 단독처리(-■-)의 경우에도 본 발명이 목적하는 항균활성능에 미치지 못하는 반면, 본 발명의 유효성분인 1:1 혼합추출액(실시예 1)의 경우에는 충치유발세균인 스트렙토코커스 뮤탄스(Streptococcus mutans)에 대해 100%의 억제활성을 나타내는 바, 본 발명의 유효성분인 1:1 혼합추출액(실시예 1)이 단독처리 추출물보다 항균활성에 대하여 상승효과가 있는 것으로 판단되었다(-◆-).
따라서, 본 발명에 의하여 제조된 치주질환 예방 및 치료용 조성물을 이용할 경우, 치주질환을 일으키는 균주에 대해 우수한 항균활성을 나타내어, 치주질환 예방 및 치료효과를 얻을 수 있게 될 것으로 사료되며, 이로 인해 건강식품, 의약품 등의 소재로 사용이 가능해짐에 따라 부가가치의 상승도 기대할 수 있게 된다.
<제제예 1: 치약 제조>
하기 표 1의 a에 속하는 성분들을 70 내지 75℃의 온도로 제조부에 투입한 후 20분간 교반하여 분체를 완전히 용해한 뒤 상온으로 냉각하였다.
이어서 보습제, 감미료 및 유용성분의 용해 공정으로서, 상기 실시예 1에서 얻어진 담체를 포함하는 b에 속하는 성분들을 25 내지 30℃로 제조부에 투입한 후 15분간 교반 혼합하여 용해하였다.
다음은 분체 및 점성제 혼합공정으로서, c에 속하는 성분들을 25 내지 35℃에서 혼합해서 단계적으로 투입하였다. 다음 공정은 기포제 혼합 및 1차 탈포 공정으로서, d에 속하는 성분을 첨가하여 25 내지 35℃에서 40분간의 공정 동안에 1차 탈포를 완료하였다. 마지막 공정은 향 혼합공정으로서, e에 속하는 성분을 첨가하고 25 내지 35℃에서 2차 탈포하여 치약을 제조하였다.
그 조성물은 다음의 표 1에 준하였다.
배합목적 | 성분명 | 규격 | 분량 | 단위 | 비고 |
용제 | 정제수 | 약전 | 적량 | a | |
기제 | 디소르비톨액 | 약전 | 33.00 | g | |
기제 | 프로필렌글리콜 | 식첨 | 5.10 | g | |
기제 | 농글리세린 | 약전 | 8.25 | g | |
주성분 | 침강탄산칼슘 | 약전 | 30.00 | g | b |
주성분 | 아미노산카프론산 | 약전 | 0.01 | g | |
주성분 | 인산일수소칼슘 | 약전 | 0.01 | g | |
점증제 | 이산화규소 | 식첨 | 18.84 | g | |
방부제 | 안식향산나트륨 | 식첨 | 0.18 | g | |
감미제 | 녹차추출물 | 약전 | 0.01 | g | |
감미제 | 삭카린나트륨 | 식첨 | 0.01 | g | |
감미제 | 자일리톨 | 식첨 | 0.01 | g | |
감미제 | 키토산 | 식첨 | 0.01 | g | |
감미제 | 프로폴리스추출물 | 별규 | 0.01 | g | |
감미제 | 실시예1의혼합추출물 | 0.01 | g | ||
기제 | 폴리에칠렌글리콜 1500 | 약전 | 0.48 | g | c |
점도조절제 | 카르복시메칠셀룰로오스나트륨 | 식첨 | 0.72 | g | |
기포제 | 라우릴황산나트륨 | 약전 | 2.44 | g | d |
착향제 | DL-멘톨 | 식첨 | 적량 | g | |
착향제 | 페파민트 | 비,피 | 적량 | g | e |
합계100g으로 맞춤 |
상기의 본 발명은 바람직한 실시예를 중심으로 살펴보았으며, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자는 본 발명의 본질적 기술 범위 내에서 상기 본 발명의 상세한 설명과 다른 형태의 실시예들을 구현할 수 있을 것이다. 여기서 본 발명의 본질적 기술범위는 특허청구범위에 나타나 있으며, 그와 동등한 범위 내에 있는 모든 차이점은 본 발명에 포함된 것으로 해석되어야 할 것이다.
Claims (12)
- 상백피추출물과 화살나무추출물을 유효성분으로 포함하여,충치 유발 세균의 성장 억제 활성을 나타내는 것이 특징인,충치 예방 및 치료용 구강조성물.
- 제1항에 있어서,상기 충치 유발 세균은 스트렙토코쿠스 뮤탄스(Streptococcus mutans)인 것을 특징으로 하는,충치 예방 및 치료용 구강조성물.
- 제 1항에 있어서,상기 상백피추출물과 화살나무추출물은 1:1 중량비로 이루어지는 것이 특징인,충치 예방 및 치료용 구강조성물.
- 제 1항에 있어서,상기 상백피추출물은 에탄올로 추출하는 것을 특징으로 하는,충치 예방 및 치료용 구강조성물.
- 제 1항에 있어서,상기 화살나무추출물은 에탄올로 추출하는 것을 특징으로 하는,충치 예방 및 치료용 구강조성물.
- 제 1항에 있어서,상기 구강조성물은 치약류, 츄잉껌, 구강 청정제, 구강 세정제 및 구강 스프레이 중 선택된 어느 하나 이상의 제형을 갖는 것을 특징으로 하는,충치 예방 및 치료용 구강조성물.
- 상백피추출물과 화살나무추출물을 유효성분으로 포함하는,충치 유발 세균의 성장 억제 활성을 나타내는 것이 특징인,충치 예방 및 개선용 건강기능식품.
- 제7항에 있어서,상기 충치 유발 세균은 스트렙토코쿠스 뮤탄스(Streptococcus mutans)인 것을 특징으로 하는,충치 예방 및 개선용 건강기능식품.
- 제7항에 있어서,상기 상백피추출물과 화살나무추출물은 1:1 중량비로 이루어지는 것이 특징인,충치 예방 및 개선용 건강기능식품.
- 제7항에 있어서,상기 상백피추출물은 에탄올로 추출하는 것을 특징으로 하는,충치 예방 및 개선용 건강기능식품.
- 제7항에 있어서,상기 화살나무추출물은 에탄올로 추출하는 것을 특징으로 하는,충치 예방 및 개선용 건강기능식품.
- 제 1항에 있어서,상기 건강기능식품은 분말, 과립, 정제, 캡슐 또는 음류 중 선택된 어느 하나 이상의 제형을 갖는 것을 특징으로 하는,충치 예방 및 개선용 건강기능식품.
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