WO2016140087A1 - 貼付剤 - Google Patents
貼付剤 Download PDFInfo
- Publication number
- WO2016140087A1 WO2016140087A1 PCT/JP2016/055010 JP2016055010W WO2016140087A1 WO 2016140087 A1 WO2016140087 A1 WO 2016140087A1 JP 2016055010 W JP2016055010 W JP 2016055010W WO 2016140087 A1 WO2016140087 A1 WO 2016140087A1
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- WO
- WIPO (PCT)
- Prior art keywords
- adhesive layer
- patch
- pressure
- sensitive adhesive
- release liner
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Definitions
- the present invention relates to a patch, and more particularly to a patch in which a pressure-sensitive adhesive layer and a release liner are laminated on a support.
- the patch generally has an adhesive layer on at least one surface of the support and a release liner for protecting the adhesive layer until the patch is used. It is required to be easily removed from the agent layer. That is, if the release liner is difficult to peel off from the adhesive layer, it becomes difficult to use when applying the patch to the skin. In extreme cases, the release liner remains attached to the adhesive layer and the adhesive layer is The problem of peeling off from the support occurs. On the other hand, when the release liner is easily peeled off from the pressure-sensitive adhesive layer, the release liner is displaced from the pressure-sensitive adhesive layer during manufacture or storage of the patch, and the pressure-sensitive adhesive layer cannot be sufficiently protected by the release liner. Occurs.
- a release agent such as a silicone resin or a fluorine resin is applied in a layer form on the surface of the release liner and fixed by crosslinking or the like so-called release treatment.
- the ones that have been applied are conventionally used.
- Patent Document 1 JP 2009-274959 A discloses that in a patch comprising an adhesive layer containing a silicone-based adhesive as an adhesive base, a polar silicone oil is added to the adhesive layer. It is described that the release property of a silicone-treated release liner is improved.
- the composition of the pressure-sensitive adhesive layer is determined from the viewpoint of adhesion to the skin, transdermal absorbability (skin permeability) of the drug to be contained therein, and stability over time, rather than releasability from the release liner. From this point of view, after the basic composition of the pressure-sensitive adhesive layer is determined, it is difficult to change the basic composition in view of the release property from the liner because there is a high risk of new problems. It is. Moreover, since the peelability of the release liner is likely to deteriorate with time, it is required to maintain an appropriate peelability stably over time without changing the basic composition of the pressure-sensitive adhesive layer.
- the present invention has been made in view of such a problem, and without changing the basic composition of the pressure-sensitive adhesive layer containing an acrylate-based pressure-sensitive adhesive or a rubber-based pressure-sensitive adhesive as an adhesive base, adhesion to the skin. In addition, it does not adversely affect the transdermal absorbability (skin permeability) and stability over time of the drug to be contained therein, and adjusts the release property with the release liner to an appropriate range and provides an appropriate release property over time. It is an object to provide a patch that can be stably maintained.
- the inventors of the present invention have a kinematic viscosity at 25 ° C. in a patch having an adhesive layer containing an acrylate adhesive or a rubber adhesive as an adhesive base.
- a non-functional silicone oil having a 10 to 350 cSt
- the adhesion to the skin, the transdermal absorbability (skin permeability) of the drug to be contained therein and the aging It has been found that it is possible to adjust the release property of the release liner from the pressure-sensitive adhesive layer to an appropriate range and maintain the appropriate release property stably over time without adversely affecting the stability.
- the invention has been completed.
- the patch of the present invention is a patch in which a pressure-sensitive adhesive layer and a release liner are laminated on at least one surface of a support, and the pressure-sensitive adhesive layer is an acrylate-based pressure-sensitive adhesive and a rubber-based pressure-sensitive adhesive base.
- a non-functional silicone oil containing at least one selected from the group consisting of pressure-sensitive adhesives and having a kinematic viscosity of 10 to 350 cSt at 25 ° C. is blended in the pressure-sensitive adhesive layer in an amount of 0.3 to 5% by mass. It is what has been.
- a drug is further blended in the pressure-sensitive adhesive layer.
- the non-functional silicone oil is at least one selected from the group consisting of dimethylpolysiloxane and methylphenylpolysiloxane.
- At least one selected from the group consisting of liquid paraffin, liquid polybutene, isopropyl palmitate, isopropyl myristate, diethyl sebacate and hexyl laurate is further blended as a plasticizer in the adhesive layer. It is preferable that
- At least one selected from the group consisting of a fatty acid having 6 to 20 carbon chains and an aliphatic alcohol having 6 to 20 carbon chains is included in the adhesive layer. It is preferable that it is further blended as
- the pressure-sensitive adhesive layer includes at least one selected from the group consisting of glycerin ester of hydrogenated rosin, alicyclic saturated hydrocarbon resin, aliphatic hydrocarbon resin, and terpene resin. It is preferable that it is further blended as a tackifier.
- the pressure-sensitive adhesive base is an acrylate copolymer
- the pressure-sensitive adhesive layer further contains a liquid fatty acid ester and a fatty acid having 6 to 20 carbon chains. preferable.
- the adhesive base is a styrene-isoprene-styrene block copolymer and polyisobutylene
- the adhesive layer contains an alicyclic saturated hydrocarbon resin, petroleum oil, liquid fatty acid ester. More preferably, an aliphatic alcohol having 6 to 20 carbon chains is further blended.
- the basic composition of the pressure-sensitive adhesive layer containing an acrylate-based pressure-sensitive adhesive or a rubber-based pressure-sensitive adhesive is changed as a pressure-sensitive adhesive base.
- the patch of the present invention comprises a support, an adhesive layer laminated on at least one surface thereof, and a release liner that covers the surface of the adhesive layer opposite to the support.
- the support is not particularly limited as long as it is a support generally used for patches, but the material is polyester such as polyethylene terephthalate (PET), polybutylene terephthalate, polyethylene naphthalate; polyolefin such as polyethylene and polypropylene; Metals such as nylon, polycarbonate, and aluminum are preferably used.
- PET polyethylene terephthalate
- PBT polybutylene terephthalate
- polyethylene naphthalate polyethylene naphthalate
- polyolefin such as polyethylene and polypropylene
- Metals such as nylon, polycarbonate, and aluminum are preferably used.
- the support is preferably in the form of a film, fabric, foil, porous sheet or the like, or a laminate of these.
- an adhesive layer is laminated on at least one surface of the support, and the adhesive layer according to the present invention is a group consisting of an acrylate adhesive and a rubber adhesive as an adhesive base.
- a non-functional silicone oil having a kinematic viscosity at 25 ° C. of 10 to 350 cSt is blended in an amount of 0.3 to 5% by mass.
- the acrylate-based pressure-sensitive adhesive according to the present invention is not particularly limited as long as it is an acrylate-based pressure-sensitive adhesive generally used as a pressure-sensitive adhesive base of a patch, but one or more (meth) acrylic acid alkyl ester homopolymers are not limited. Even if it is a polymer or a copolymer, the copolymer of a (meth) acrylic-acid alkylester and a comonomer component other than these may be sufficient.
- Examples of the (meth) acrylic acid alkyl ester include butyl (meth) acrylate, isobutyl (meth) acrylate, hexyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, octyl (meth) acrylate, (meth ) Isooctyl acrylate, decyl (meth) acrylate and the like are exemplified, but from the viewpoint of adhesive properties, 2-ethylhexyl (meth) acrylate and octyl (meth) acrylate are preferred, and 2-ethylhexyl (meth) acrylate is preferred. More preferred.
- Examples of the comonomer component include 2-hydroxyethyl (meth) acrylate, (meth) acrylic acid, ethylene, propylene, styrene, vinyl acetate, N-vinyl-pyrrolidone, acrylamide, and the like. Are preferred, and 2-hydroxyethyl (meth) acrylate, vinyl acetate, and N-vinyl-pyrrolidone are preferred from the viewpoint that the solubility of the drug and the skin permeability tend to be better.
- the comonomer component may be used alone or in combination of two or more.
- an acrylate-based pressure-sensitive adhesive As the acrylate-based pressure-sensitive adhesive according to the present invention, an acrylate-vinyl acetate copolymer, an acrylic resin is used from the viewpoint that the cohesive strength of the pressure-sensitive adhesive is maintained and the drug solubility and skin permeability tend to be better.
- Acrylate ester copolymers such as 2-ethylhexyl acid-vinylpyrrolidone copolymer are preferred, and acrylate ester-vinyl acetate copolymers having an alcoholic hydroxyl group are more preferred.
- Such acrylate-based pressure-sensitive adhesives may be used alone or in combination of two or more. Specific examples of the acrylate adhesive include DURO-TAK 87-2516, DURO-TAK 87-4287, DURO-TAK 87-2287 (trade name, manufactured by Henkel), and the like.
- the rubber-based pressure-sensitive adhesive according to the present invention is not particularly limited as long as it is a rubber-based pressure-sensitive adhesive generally used as a pressure-sensitive adhesive base for patches, but a styrene-isoprene-styrene block copolymer (SIS), isoprene rubber, Examples include polyisobutylene (PIB), styrene-butadiene-styrene block copolymer (SBS), styrene-butadiene rubber (SBR), natural rubber, and the like. SIS and PIB are preferable from the viewpoint that they tend to be. Such rubber-based pressure-sensitive adhesives may be used alone or in combination of two or more.
- rubber adhesives include Opanol B12, B15, B50, B80, B100, B120, B150, B220 (trade names, manufactured by BASF); JSR butyl 065, 268, 365 (trade names, manufactured by JSR) ; Vistanex LM-MS, MH, H, MML-80, 100, 120, 140 (trade name, manufactured by Exxon Chemical); HYCAR (trade name, manufactured by Goodrich); SIBSTAR T102 (trade name, Kaneka) Etc.).
- the amount of at least one compound selected from the group consisting of an acrylate-based adhesive and a rubber-based adhesive contained as an adhesive base in the adhesive layer according to the present invention is not particularly limited, but the total mass (adhesive of the adhesive layer)
- the base is preferably 20 to 99% by mass, more preferably 30 to 95% by mass based on the solid content).
- the non-functional silicone oil having a kinematic viscosity at 25 ° C. of 10 to 350 cSt is blended in an amount of 0.3 to 5% by mass. Silicone oil functions as a releasability improver, and releasability with a release liner, which will be described later, is adjusted to an appropriate range, and appropriate releasability is stably maintained over time.
- Such a non-functional silicone oil is an oily substance having a siloxane bond (Si—O—Si) as a main chain, and includes polar functional groups such as polyethylene glycol chains and hydroxyl groups, and reactive functional groups (amino groups).
- polar functional groups such as polyethylene glycol chains and hydroxyl groups
- reactive functional groups as amino groups.
- Epoxy group, carbinol group, carboxyl group, mercapto group, etc. means a non-reactive silicone oil in which no side chain or terminal is introduced.
- Non-functional silicone oils used in the present invention include alkylpolysiloxanes such as dimethylpolysiloxane and methylethylpolysiloxane, alkylarylpolysiloxanes such as methylphenylpolysiloxane, and alkylhydrogenpolysiloxanes such as methylhydrogenpolysiloxane.
- dimethylpolysiloxane, methylethylpolysiloxane, methylphenylpolysiloxane and the like are preferable, dimethylpolysiloxane, methylphenylpolysiloxane and the like are more preferable, Dimethylpolysiloxane is particularly preferred.
- dimethylpolysiloxane is also called methylpolysiloxane or dimethicone, and is an oily substance represented by the following structural formula.
- non-functional silicone oils those having various viscosities are used as raw materials for pharmaceuticals and cosmetics, from those having low viscosity (low molecular weight) to those having high viscosity (high molecular weight).
- the release liner is excessively easily peeled off from the pressure-sensitive adhesive layer, and the release liner is displaced from the pressure-sensitive adhesive layer at the time of manufacturing or storing the patch. There arises a problem that the pressure-sensitive adhesive layer cannot be sufficiently protected.
- the kinematic viscosity at 25 ° C. is in the range of 15 to 300 cSt from the viewpoint that it is possible to adjust the peelability from the release liner to a more appropriate range and to maintain a proper peelability over time. It is preferable to use those within the range, and it is more preferable to use those within the range of 20 to 250 cSt.
- kinematic viscosity means a value measured at 25 ° C. using, for example, a capillary viscometer (Ubbelohde type, Canon-Fenske type, etc.).
- the non-functional silicone oil based on the total mass of the pressure-sensitive adhesive layer (in terms of the solid content in terms of the pressure-sensitive adhesive base).
- the blending amount of the non-functional silicone oil is less than 0.3% by mass, the releasability from the release liner is not sufficiently improved, the releasability deteriorates with time, and the release liner is difficult to peel off from the adhesive layer. This causes a problem that it is difficult to use the patch when it is applied to the skin.
- the pressure-sensitive adhesive layer is excessively plasticized, and liquid components ooze out on the surface of the pressure-sensitive adhesive layer (bleed), and are applied to the skin. There arises a problem that adhesion is lowered. Furthermore, when the blending amount of the non-functional silicone oil exceeds 5% by mass, the release liner is excessively easily peeled off from the pressure-sensitive adhesive layer, and the release liner is displaced from the pressure-sensitive adhesive layer during production or storage of the patch. Therefore, there arises a problem that the pressure-sensitive adhesive layer cannot be sufficiently protected by the release liner.
- the amount of the non-functional silicone oil is preferably 0.3 to 4% by mass, preferably 0.3 to 3% by mass based on the total mass of the pressure-sensitive adhesive layer (in terms of solid content in terms of the adhesive base). It is more preferable.
- the reason why the non-functional silicone oil having a kinematic viscosity at 25 ° C. of 10 to 350 cSt improves the release property of the release liner is not clear, but the non-functional silicone oil having the above kinematic viscosity is added to the pressure-sensitive adhesive layer.
- the present inventors infer that the presence of the specific effect of stably reducing the excessive adhesive force at the interface between the release liner and the pressure-sensitive adhesive layer with time can be obtained.
- a drug physiologically active ingredient
- a solubilizer for the drug or the like is blended appropriately depending on the drug used. Also good.
- the drug suitably blended in the pressure-sensitive adhesive layer is not particularly limited as long as it is percutaneously absorbed into the body and exhibits physiological activity.
- drugs include non-steroidal anti-inflammatory analgesics (diclofenac, indomethacin, ketoprofen, felbinac, loxoprofen, ibuprofen, flurbiprofen, thiaprofen, acemetacin, sulindac, etodolac, tolmethine, piroxicam, meloxicam, ampiroxicam, naproxen, Azapropazone, methyl salicylate, glycol salicylate, valdecoxib, celecoxib, rofecoxib, ampenac, etc., antihistamines (diphenhydramine, chlorpheniramine, mequitazine, homochlorcyclodine, etc.), antihypertensives (diltiazem, nicardipine, nil
- the aforementioned drugs may be used alone or in combination of two or more.
- the drug may be in the form of a pharmaceutically acceptable salt.
- the blending amount of the drug is not particularly limited and is appropriately blended according to the purpose, but generally 0.1% based on the total mass of the pressure-sensitive adhesive layer (in terms of solid content in terms of the pressure-sensitive adhesive base). It is preferably ⁇ 70% by mass, more preferably 1 to 50% by mass, even more preferably 3 to 30% by mass.
- additives such as a tackifier, a plasticizer, a transdermal absorption accelerator, a filler, and a stabilizer may be further blended in the pressure-sensitive adhesive layer.
- the tackifier that can be blended in the pressure-sensitive adhesive layer is not particularly limited as long as it is a tackifier generally used in patches, rosin, glycerin ester of rosin, Rosin derivatives such as hydrogenated rosin, glycerin ester of hydrogenated rosin, pentaerythritol ester of rosin; alicyclic saturated hydrocarbon resins such as Alcon P100 (trade name, Arakawa Chemical Industries); Quinton B170 (trade name, Nippon Zeon) An aliphatic hydrocarbon resin such as); a terpene resin such as Clearon P-125 (trade name, Yasuhara Chemical); and a maleic acid copolymer resin.
- glycerol ester of hydrogenated rosin, alicyclic saturated hydrocarbon resin, aliphatic hydrocarbon resin, and terpene resin are preferable.
- the tackifier may be used alone or in combination of two or more. By containing such a tackifier, the adhesiveness of the resulting pressure-sensitive adhesive layer is further improved, and other physical properties tend to be stably maintained.
- the compounding amount of the tackifier is not particularly limited, but generally it is preferably 70% by mass or less based on the total mass of the adhesive layer (in terms of the solid content in terms of the adhesive base), and preferably 10 to 60% by mass. % Is more preferable.
- liquid paraffin liquid polybutene, isopropyl palmitate, isopropyl myristate, diethyl sebacate, and hexyl laurate are preferable, and liquid polybutene, isopropyl palmitate, isopropyl myristate, and liquid paraffin are particularly preferable.
- the plasticizers may be used alone or in combination of two or more.
- the blending amount of the plasticizer is not particularly limited, but in general, it is preferably 60% by mass or less based on the total mass of the pressure-sensitive adhesive layer (in terms of the solid content in terms of the pressure-sensitive adhesive base), and 0.5 to 50%. More preferably, it is more preferably 1 to 40% by weight, still more preferably 2 to 30% by weight.
- the percutaneous absorption enhancer that can be blended in the pressure-sensitive adhesive layer is appropriately blended according to the drug to be used, and is not particularly limited.
- transdermal absorption promoters include organic acids, fatty acids having 6 to 20 carbon chains, aliphatic alcohols having 6 to 20 carbon chains, fatty acid esters having 6 to 20 carbon chains, amides, ethers, and aromatics.
- Aromatic organic acids, aromatic alcohols, aromatic organic acid esters and ethers (above may be either saturated or unsaturated, and may be either cyclic or linear branched), lactic acid esters , Acetate esters, monoterpene compounds, sesquiterpene compounds, Azone, Azone derivatives, pyrothiodecane, glycerin fatty acid esters, propylene glycol fatty acid esters, sorbitan fatty acid esters, polysorbates, polyethylene glycol fatty acids Esters, polyoxyethylene hydrogenated castor oil, polyoxyethylene Examples include alkyl ethers, sucrose fatty acid esters, vegetable oils, etc., and fatty acids having 6 to 20 carbon chains and carbon chain numbers from the viewpoint that drug solubility is high and crystal precipitation tends to be more reliably prevented. A fatty alcohol having 6 to 20 carbon atoms is preferred, and a fatty acid having 6 to 20 carbon chains is more preferred.
- transdermal absorption enhancer examples include lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, lauryl alcohol, myristyl alcohol, oleyl alcohol, Stearyl alcohol, cetyl alcohol, octyldodecanol, methyl laurate, hexyl laurate, diethanolamide laurate, isopropyl myristate, myristyl myristate, octyldodecyl myristate, cetyl palmitate, methyl salicylate, ethylene glycol salicylate, triethyl citrate , Cetyl lactate, lauryl lactate, ethyl acetate, propyl acetate, geraniol, thymol, eugenol, terpineol, l-menthol, borneo
- the transdermal absorption enhancer may be used alone or in combination of two or more.
- the blending amount of the transdermal absorption enhancer is not particularly limited, but is generally preferably 30% by mass or less based on the total mass of the pressure-sensitive adhesive layer (in terms of solid content in terms of the pressure-sensitive adhesive base). More preferably, it is 5 to 15% by mass, and even more preferably 2 to 10% by mass.
- the stabilizer that can be blended in the pressure-sensitive adhesive layer is appropriately blended according to the drug to be used and other additive components, and is not particularly limited, but is not limited to antioxidants (tocopherol derivatives, ascorbic acid). Derivatives, erythorbic acid derivatives, nordihydroguaiaretic acid, gallic acid derivatives, dibutylhydroxytoluene (BHT), butylhydroxyanisole, sodium pyrosulfite, sodium sulfite, etc.), UV absorbers (imidazole derivatives, benzotriazole derivatives, p- Aminobenzoic acid derivatives, anthranilic acid derivatives, salicylic acid derivatives, cinnamic acid derivatives, benzophenone derivatives, coumaric acid derivatives, camphor derivatives, etc.).
- antioxidants tocopherol derivatives, ascorbic acid.
- the filler that can be blended in the pressure-sensitive adhesive layer is not particularly limited, but calcium carbonate, magnesium carbonate, silicate, cellulose derivatives (hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxy) And methyl cellulose).
- the thickness of the pressure-sensitive adhesive layer in the patch of the present invention is not particularly limited, but generally it is preferably 50 to 500 ⁇ m, more preferably 50 to 300 ⁇ m.
- the surface of the pressure-sensitive adhesive layer opposite to the support is coated with a release liner.
- a release liner is a release film for covering and protecting the pressure-sensitive adhesive layer, and is not particularly limited as long as it is a release liner generally used for a patch.
- release liners include materials such as polyester (polyethylene terephthalate, polyethylene naphthalate, polybutylene terephthalate, etc.), polyolefin (polyethylene, polypropylene, etc.), paper, cellulose derivatives, etc. It is preferable to apply a release treatment by coating silicone, Teflon (registered trademark) or the like on the surface in contact with the resin, and a silicone-treated polyethylene terephthalate film is particularly preferably used.
- the method for producing the patch of the present invention is not particularly limited except that the non-functional silicone oil is blended when obtaining the pressure-sensitive adhesive layer, and a general method for producing a patch (solvent method, hot melt method, etc.)
- a general method for producing a patch solvent method, hot melt method, etc.
- the patch of the present invention can be obtained.
- the aforementioned non-functional silicone oil, adhesive base, drug (physiologically active ingredient), additive ingredient, etc. are mixed and dissolved in an organic solvent, and the resulting adhesive solution is applied to a release liner, and then the solvent is added.
- the patch of the present invention can be obtained by drying and removing, laminating a support on the formed pressure-sensitive adhesive layer, and appropriately cutting the obtained patch sheet.
- Peelability improvers non-functional silicone oil, polar silicone oil, polyvinyl pyrrolidone, zinc oxide, glycinal, bentonite, kaolin, talc
- adhesive base acrylic ester copolymer shown in Table 1 and Table 2 below
- Additive components isopropyl palmitate (plasticizer), oleic acid (percutaneous absorption enhancer)) were weighed and mixed so as to have the composition shown in Table 1 and Table 2 below. An adhesive solution was obtained.
- the obtained pressure-sensitive adhesive solution was applied onto a release liner (PET film whose surface was release-treated with silicone), and the solvent was removed by drying to form a pressure-sensitive adhesive layer (thickness of the resulting pressure-sensitive adhesive layer) Is 100 g / m 2 ).
- a support PET film
- the obtained patch was sealed and packaged in a packaging bag made of an aluminum laminate film.
- the compounding quantity of Table 1 and Table 2 is a compounding quantity (mass%) on the basis of the total mass of an adhesive layer, and is the compounding quantity converted into solid content about an adhesive base. Moreover, the blank in Table 1 and Table 2 shows that it is 0 (zero).
- the release liner is displaced from the adhesive layer (failed) 2: Can be peeled with a light force, but the release liner may be displaced from the adhesive layer (fail) 3: The release liner is not displaced from the adhesive layer and can be peeled off with an appropriate force (pass) 4: Although the release liner is not displaced from the adhesive layer, it requires a slightly strong force to peel off (quasi-pass) 5: The release liner is not displaced from the pressure-sensitive adhesive layer, but requires a very strong force to peel off (fail).
- the patches obtained in Examples 1 and 2 blended with the non-functional silicone oil according to the present invention have improved detachability without causing bleeding.
- the patch of Example 1 had an appropriate release liner release property and maintained an appropriate release property stably over time.
- Example 3 and Comparative Example 13 Peelability improver (non-functional silicone oil), adhesive base (styrene-isoprene-styrene block copolymer, polyisobutylene) and additive components (alicyclic saturated hydrocarbon resin (tackifier) shown in Table 5 below ), Liquid paraffin (plasticizer), isopropyl palmitate (plasticizer), octyldodecanol (transdermal absorption enhancer)), and weigh each component so as to have the composition shown in Table 5 below.
- a patch was obtained and sealed in a packaging bag in the same manner as in Example 1 except that the adhesive solution obtained by dissolving in (toluene) was used.
- the compounding quantity of Table 5 is also a compounding quantity (mass%) on the basis of the total mass of an adhesive layer, and is the compounding quantity converted into solid content about an adhesive base.
- the patch obtained in Example 3 formulated with the non-functional silicone oil according to the present invention was improved in peelability without causing bleeding, and was moderate. It was confirmed that the release liner has the release property and the appropriate release property is stably maintained over time. On the other hand, in the patch obtained in Comparative Example 13 in which no peelability improver was blended, the peelability deteriorated with time, and the release liner was very difficult to peel off.
- Example 7 Peelability improver (non-functional silicone oil), adhesive base (acrylic ester copolymer), additive components (isopropyl palmitate (plasticizer), oleic acid (transdermal absorption enhancer) shown in Table 7 below )), Each component was weighed so as to have the composition shown in Table 7 below, and the adhesive solution was obtained in the same manner as in Example 1 except that the adhesive solution obtained by mixing was used. And sealed in a packaging bag.
- the compounding quantity of Table 7 is also a compounding quantity (mass%) on the basis of the total mass of an adhesive layer, and is the compounding quantity converted into solid content about an adhesive base.
- Example 9 Peelability improver (non-functional silicone oil), adhesive base (acrylic ester copolymer), additive components (isopropyl palmitate (plasticizer), oleic acid (transdermal absorption enhancer) shown in Table 9 below )), Each component was weighed so as to have the composition shown in Table 9 below, and the adhesive was obtained in the same manner as in Example 1 except that the adhesive solution obtained by mixing was used. And sealed in a packaging bag.
- the compounding quantity of Table 9 is also a compounding quantity (mass%) on the basis of the total mass of an adhesive layer, and is the compounding quantity converted into solid content about an adhesive base. A blank in Table 9 indicates 0 (zero).
- the patches obtained in Examples 1, 2, and 9 to 12 containing the non-functional silicone oil according to the present invention improved the peelability without causing bleeding. It was confirmed that the release property of the release liner was appropriate and that the appropriate release property was stably maintained over time. On the other hand, in the patch obtained in Comparative Example 10 containing a kinematic viscosity higher than that of the non-functional silicone oil according to the present invention, the peelability deteriorated with time and almost no improvement in peelability was observed. .
- the release liner may be displaced from the adhesive layer although it can be peeled off with a light force. There was a failure.
- Examples 13 to 14 and Comparative Examples 17 to 18 Drugs (galantamine), release improver (non-functional silicone oil), adhesive base (acrylic ester copolymer), additive components (isopropyl palmitate (plasticizer), oleic acid (tablet 11) shown in Table 11 below Using the transdermal absorption enhancer)), each component was weighed so as to have the composition shown in Table 11 below, and the pressure-sensitive adhesive solution obtained by mixing was used as in Example 1. Thus, a patch was obtained and sealed in a packaging bag.
- the compounding quantity of Table 11 is also a compounding quantity (mass%) on the basis of the total mass of an adhesive layer, and is the compounding quantity converted into solid content about an adhesive base.
- a “skin adhesion test”, “transdermal absorbability test”, and “drug aging stability test” were performed by the following methods.
- the patch of the present invention peels without adversely affecting the adhesion to the skin, transdermal absorbability (skin permeability) and stability over time of the drug contained therein. It was confirmed that it was possible to adjust the peelability from the liner to an appropriate range and to maintain an appropriate peelability stably over time.
- ⁇ Skin adhesion test> Each patch was peeled from the release liner, and the adhesive was evaluated for cohesive force and adhesive strength when the thumb was pressed against the surface of the adhesive layer and then released. Further, each patch was applied to the stratum corneum side of human skin (abdomen) for testing and stored at 32 ⁇ 1 ° C. for 3 hours, and then the patch was peeled off, and the peeling resistance at that time was evaluated.
- ⁇ Percutaneous absorption test> Using skin (body part) removed from 7-10 week-old hairless mice and fat removed from the stratum corneum, or human skin for test (abdomen) cut to a thickness of about 500 ⁇ m from the stratum corneum (dermatome), Each patch (3 cm 2 ) was affixed, and the dermis side was the receptor layer side, which was then attached to the flow-through diffusion cell. On the receptor layer side, warm water was circulated around the outer periphery using a pH 7.4 phosphate buffered saline so that the skin surface temperature was 32 ⁇ 1 ° C.
- the flow rate of the receptor fluid is 2.5 mL / hour, sampling is performed every 4 hours, the receptor solution obtained at each point is measured accurately, the drug concentration is measured by high performance liquid chromatography, and the flow rate is measured.
- the drug permeation rate per hour of each patch was calculated from the measured value of the drug concentration.
- the drug content was determined by the following method. That is, first, the release liner was peeled from the patch and put into a 50 mL centrifuge tube. Next, 10 mL of hydrochloric acid / methanol solution as an extract was placed in a 50 mL centrifuge tube and shaken for 1 hour. Next, an internal standard substance (methyl p-hydroxybenzoate / (hydrochloric acid / methanol solution)) was added, and this was made up to 50 mL with a water / methanol solution and shaken for 30 minutes. Each prepared sample was analyzed by high performance liquid chromatography to determine the drug content.
- Examples 15 to 32 Indomethacin (Example 15), ketoprofen (Example 16), felbinac (Example 17), methyl salicylate (Example 18), glycol salicylate (Example 19), bisoprolol (Example 20), pergolide (Example) 21), ropinirole (Example 22), tulobuterol (Example 23), ketotifen (Example 24), lidocaine (Example 25), oxybutynin (Example 26), tamsulosin (Example 27), asenapine (Example 28) ), Estradiol (Example 29), risperidone (Example 30), rivastigmine (Example 31), and methylphenidate (Example 32), respectively.
- Using each patch perform the “Release test of release liner” and the method described above. We went to "bleed anti-test”.
- the adhesive layer containing an acrylate adhesive or a rubber adhesive as the adhesive base.
- the adhesiveness to the skin, the transdermal absorbability (skin permeability) of the drug to be contained in the skin and the stability over time can be removed without adversely affecting the release liner. It becomes possible to adjust to an appropriate range and to maintain appropriate peelability stably over time.
- the present invention does not change the basic composition of these adhesive layers. It is very useful as a technique for adjusting the peelability with the release liner to an appropriate range and maintaining the appropriate peelability stably over time.
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Abstract
Description
下記の表1及び表2に示す剥離性向上剤(無官能性シリコーンオイル、極性シリコーンオイル、ポリビニルピロリドン、酸化亜鉛、グリシナール、ベントナイト、カオリン、タルク)、粘着基剤(アクリル酸エステル系共重合体)、添加成分(パルミチン酸イソプロピル(可塑剤)、オレイン酸(経皮吸収促進剤))を用いて、下記の表1及び表2に示す組成となるように各成分を秤量し、混合して粘着剤溶液を得た。次いで、得られた粘着剤溶液を、剥離ライナー(表面をシリコーンにより離型処理したPETフィルム)上に塗布し、溶媒を乾燥除去して粘着剤層を形成した(得られた粘着剤層の厚みは100g/m2)。次に、粘着剤層の上に支持体(PETフィルム)を積層し、裁断して貼付剤を得た。その後、得られた貼付剤をアルミラミネートフィルムからなる包装袋に密封して包装した。
前記包装袋に密封する前の各貼付剤(初期)、並びに、前記包装袋に密封した各貼付剤を60℃のチャンバー内に1週間保存した後に包装袋を開封して取り出した各貼付剤(60℃/1W)について、貼付剤から剥離ライナーを除去する際の剥がしやすさ(剥がすために要する力の強さ)について、以下の基準に基づいて評価した。
1:剥離ライナーが粘着剤層からずれている(不合格)
2:軽い力で剥がせるが、剥離ライナーが粘着剤層からずれている場合がある(不合格)
3:剥離ライナーが粘着剤層からずれておらず、適度な力で剥がせる(合格)
4:剥離ライナーが粘着剤層からずれていないが、剥がすのにやや強い力を要する(準合格)
5:剥離ライナーが粘着剤層からずれていないが、剥がすのに非常に強い力を要する(不合格)。
前記包装袋に密封する前の各貼付剤(初期)、並びに、前記包装袋に密封した各貼付剤を60℃のチャンバー内に1週間保存した後に包装袋を開封して取り出した各貼付剤(60℃/1W)について、貼付剤から剥離ライナーを除去した。各貼付剤の表面に液体が染み出しているかについて、以下の基準に基づいて評価した。
A:染み出しは観察されなかった(合格)
B:僅かな染み出しが観察された(準合格)
C:顕著な染み出しが観察された(不合格)。
下記の表5に示す剥離性向上剤(無官能性シリコーンオイル)、粘着基剤(スチレン-イソプレン-スチレンブロック共重合体、ポリイソブチレン)、添加成分(脂環族飽和炭化水素樹脂(粘着付与剤)、流動パラフィン(可塑剤)、パルミチン酸イソプロピル(可塑剤)、オクチルドデカノール(経皮吸収促進剤))を用いて、下記の表5に示す組成となるように各成分を秤量し、溶媒(トルエン)中に溶解して得られた粘着剤溶液を用いるようにしたこと以外は実施例1と同様にして貼付剤を得て包装袋に密封した。なお、表5中の配合量も粘着剤層の全質量を基準とした配合量(質量%)であり、粘着基剤に関しては固形分換算した配合量である。
下記の表7に示す剥離性向上剤(無官能性シリコーンオイル)、粘着基剤(アクリル酸エステル系共重合体)、添加成分(パルミチン酸イソプロピル(可塑剤)、オレイン酸(経皮吸収促進剤))を用いて、下記の表7に示す組成となるように各成分を秤量し、混合して得られた粘着剤溶液を用いるようにしたこと以外は実施例1と同様にして貼付剤を得て包装袋に密封した。なお、表7中の配合量も粘着剤層の全質量を基準とした配合量(質量%)であり、粘着基剤に関しては固形分換算した配合量である。
下記の表9に示す剥離性向上剤(無官能性シリコーンオイル)、粘着基剤(アクリル酸エステル系共重合体)、添加成分(パルミチン酸イソプロピル(可塑剤)、オレイン酸(経皮吸収促進剤))を用いて、下記の表9に示す組成となるように各成分を秤量し、混合して得られた粘着剤溶液を用いるようにしたこと以外は実施例1と同様にして貼付剤を得て包装袋に密封した。なお、表9中の配合量も粘着剤層の全質量を基準とした配合量(質量%)であり、粘着基剤に関しては固形分換算した配合量である。また、表9中の空欄は0(ゼロ)であることを示す。
下記の表11に示す薬物(ガランタミン)、剥離性向上剤(無官能性シリコーンオイル)、粘着基剤(アクリル酸エステル系共重合体)、添加成分(パルミチン酸イソプロピル(可塑剤)、オレイン酸(経皮吸収促進剤))を用いて、下記の表11に示す組成となるように各成分を秤量し、混合して得られた粘着剤溶液を用いるようにしたこと以外は実施例1と同様にして貼付剤を得て包装袋に密封した。なお、表11中の配合量も粘着剤層の全質量を基準とした配合量(質量%)であり、粘着基剤に関しては固形分換算した配合量である。
各貼付剤を剥離ライナーから剥離し、粘着剤層の表面に親指を押し付けてから離した際の貼付剤の凝集力、粘着力について評価した。また、試験用のヒト皮膚(腹部)の角質層側に各貼付剤を貼って32±1℃で3時間保存した後に貼付剤を剥離し、その際の剥離抵抗を評価した。
7~10週齢のヘアレスマウスより摘出し脂肪を除去した皮膚(体側部)もしくは角質層側から約500μmの厚みに切断(ダーマトーム)した試験用のヒト皮膚(腹部)を用い、角質層側に各貼付剤(3cm2)を貼付し、真皮側をレセプター層側にして、フロースルー型拡散セルに装着した。そして、レセプター層側にはpH7.4のリン酸緩衝生理食塩水を用いて、皮膚表面温度が32±1℃となるように温水を外周部に循環させた。レセプター液の流速は2.5mL/時間の速さとし、サンプリングは4時間毎に行い、各ポイントで得られたレセプター溶液は、流量を正確に測り、高速液体クロマトグラフィーにより薬物濃度を測定し、流量及び薬物濃度の測定値より各貼付剤の1時間あたりの薬物透過速度を算出した。
各貼付剤を6.25cm2の大きさに裁断し、試験に用いるサンプルを得た。温度60℃、湿度75%の恒温恒湿槽中に2週間及び1ヶ月保存した各サンプルの測定により得られた薬物の含有量(Ni)、及び初期サンプルの測定で得られた薬物の含有量(N0)の値を下記式(1):
Ri(%)=(Ni/N0)×100 (1)
に示す関係式に代入して得られた値(Ri)を、各サンプルにおける薬物の各条件における保管後の対初期値(%)とした。
薬物としてインドメタシン(実施例15)、ケトプロフェン(実施例16)、フェルビナク(実施例17)、サリチル酸メチル(実施例18)、サリチル酸グリコール(実施例19)、ビソプロロール(実施例20)、ペルゴリド(実施例21)、ロピニロール(実施例22)、ツロブテロール(実施例23)、ケトチフェン(実施例24)、リドカイン(実施例25)、オキシブチニン(実施例26)、タムスロシン(実施例27)、アセナピン(実施例28)、エストラジオール(実施例29)、リスペリドン(実施例30)、リバスチグミン(実施例31)、メチルフェニデート(実施例32)をそれぞれ用いるようにしたこと以外は実施例13と同様にして得られた各貼付剤を用いて、前述の方法で「剥離ライナーの剥離性試験」及び「ブリード防止性試験」を行った。
Claims (8)
- 支持体の少なくとも一方の面に粘着剤層及び剥離ライナーが積層されてなる貼付剤であって、前記粘着剤層が粘着基剤としてアクリレート系粘着剤及びゴム系粘着剤からなる群から選択される少なくとも一種を含有するものであり、かつ、該粘着剤層に25℃における動粘度が10~350cStである無官能性シリコーンオイルが0.3~5質量%配合されている貼付剤。
- 前記粘着剤層に薬物がさらに配合されている請求項1に記載の貼付剤。
- 前記無官能性シリコーンオイルが、ジメチルポリシロキサン及びメチルフェニルポリシロキサンからなる群から選択される少なくとも一種である請求項1又は2に記載の貼付剤。
- 前記粘着剤層に、流動パラフィン、液状ポリブテン、パルミチン酸イソプロピル、ミリスチン酸イソプロピル、セバシン酸ジエチル及びラウリン酸ヘキシルからなる群から選択される少なくとも一種が可塑剤としてさらに配合されている請求項1~3のうちのいずれか一項に記載の貼付剤。
- 前記粘着剤層に、炭素鎖数6~20の脂肪酸及び炭素鎖数6~20の脂肪族アルコールからなる群から選択される少なくとも一種が経皮吸収促進剤としてさらに配合されている請求項1~4のうちのいずれか一項に記載の貼付剤。
- 前記粘着剤層に、水添ロジンのグリセリンエステル、脂環族飽和炭化水素樹脂、脂肪族系炭化水素樹脂及びテルペン樹脂からなる群から選択される少なくとも一種が粘着付与剤としてさらに配合されている請求項1~5のうちのいずれか一項に記載の貼付剤。
- 前記粘着基剤がアクリル酸エステル系共重合体であり、前記粘着剤層に液状脂肪酸エステル類及び炭素鎖数6~20の脂肪酸がさらに配合されている請求項1~3のうちのいずれか一項に記載の貼付剤。
- 前記粘着基剤がスチレン-イソプレン-スチレンブロック共重合体及びポリイソブチレンであり、前記粘着剤層に脂環族飽和炭化水素樹脂、石油系オイル、液状脂肪酸エステル類及び炭素鎖数6~20の脂肪族アルコールがさらに配合されている請求項1~3のうちのいずれか一項に記載の貼付剤。
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US15/554,923 US10369116B2 (en) | 2015-03-02 | 2016-02-22 | Patch comprising an adhesive layer having a nonfunctional silicone oil |
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EP16758781.5A EP3266451B1 (en) | 2015-03-02 | 2016-02-22 | Adhesive plaster |
CN201680012491.9A CN107427472B (zh) | 2015-03-02 | 2016-02-22 | 贴附剂 |
JP2017503422A JP6360614B2 (ja) | 2015-03-02 | 2016-02-22 | 貼付剤 |
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2016
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JP2023022245A (ja) * | 2016-12-20 | 2023-02-14 | エルテーエス ローマン テラピー-ジステーメ アーゲー | アセナピンを含有する経皮治療システム |
CN110087640A (zh) * | 2016-12-20 | 2019-08-02 | 罗曼治疗系统股份公司 | 包含阿塞那平的透皮治疗系统 |
JP2020503381A (ja) * | 2016-12-20 | 2020-01-30 | エルテーエス ローマン テラピー−ジステーメ アーゲー | アセナピンを含有する経皮治療システム |
US20180193283A1 (en) * | 2016-12-20 | 2018-07-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
US10898449B2 (en) | 2016-12-20 | 2021-01-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
US10980753B2 (en) | 2016-12-20 | 2021-04-20 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
JP7236389B2 (ja) | 2016-12-20 | 2023-03-09 | エルテーエス ローマン テラピー-ジステーメ アーゲー | アセナピンを含有する経皮治療システム |
US11337932B2 (en) | 2016-12-20 | 2022-05-24 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
US11033512B2 (en) | 2017-06-26 | 2021-06-15 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer |
US11648213B2 (en) | 2018-06-20 | 2023-05-16 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
JP2020083885A (ja) * | 2018-11-16 | 2020-06-04 | 得生製薬股▲ふん▼有限公司 | 経皮吸収型パッチ |
JP7170124B2 (ja) | 2019-10-28 | 2022-11-11 | 久光製薬株式会社 | アセナピン-n-オキシドの生成を抑制する方法 |
JPWO2021085211A1 (ja) * | 2019-10-28 | 2021-11-25 | 久光製薬株式会社 | アセナピン−n−オキシドの生成を抑制する方法 |
WO2021085211A1 (ja) * | 2019-10-28 | 2021-05-06 | 久光製薬株式会社 | アセナピン-n-オキシドの生成を抑制する方法 |
Also Published As
Publication number | Publication date |
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KR101942677B1 (ko) | 2019-01-25 |
JP6360614B2 (ja) | 2018-07-18 |
TW201638265A (zh) | 2016-11-01 |
EP3266451B1 (en) | 2020-09-16 |
TWI664265B (zh) | 2019-07-01 |
KR20170120181A (ko) | 2017-10-30 |
CN107427472A (zh) | 2017-12-01 |
US10369116B2 (en) | 2019-08-06 |
CN107427472B (zh) | 2021-04-30 |
EP3266451A4 (en) | 2018-08-22 |
JPWO2016140087A1 (ja) | 2017-12-07 |
EP3266451A1 (en) | 2018-01-10 |
US20180085323A1 (en) | 2018-03-29 |
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