WO2016101347A1 - 一种适于糖尿病人饮用的功能饮料及其制备方法 - Google Patents

一种适于糖尿病人饮用的功能饮料及其制备方法 Download PDF

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WO2016101347A1
WO2016101347A1 PCT/CN2015/070208 CN2015070208W WO2016101347A1 WO 2016101347 A1 WO2016101347 A1 WO 2016101347A1 CN 2015070208 W CN2015070208 W CN 2015070208W WO 2016101347 A1 WO2016101347 A1 WO 2016101347A1
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extract
functional beverage
parts
natural
health
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English (en)
French (fr)
Inventor
张贯京
陈兴明
葛新科
张少鹏
方静芳
普拉纽克 克里斯基捏
艾琳娜 古列莎
伊万 波达别特
高伟明
梁昊原
梁艳妮
周荣
徐之艳
周亮
肖应芬
郑慧华
唐小浪
李潇云
王海荣
程金兢
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Shenzhen Qianhai AnyCheck Information Technology Co Ltd
E Techno Information Technologies Co Ltd
Bio Tech Academy China Co Ltd
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Shenzhen Qianhai AnyCheck Information Technology Co Ltd
E Techno Information Technologies Co Ltd
Bio Tech Academy China Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/70—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the invention relates to the field of functional food technology, in particular to a pure natural functional beverage suitable for drinking by a diabetic based on health promotion.
  • Diabetes is a chronic non-infectious, metabolic disease characterized by elevated blood glucose levels that seriously endangers human health. Whether in developed or developing countries, diabetes has become an epidemic in modern society and has become a worldwide public health problem that seriously threatens human health.
  • the results of WHO statistics and predictions are as follows: In 1994, the number of people with diabetes was 120 million. In 1997, it was 135 million, in 2000 it was 175 million, in 2010 it was 239 million, and in 2025 it is expected to exceed 300 million. And the trend of a sharp increase in diabetes in the last three or fifty years will continue.
  • Diabetes is a huge hazard, which not only affects the quality of life of patients, but also imposes a heavy psychological burden on patients.
  • Diabetes-induced complications such as kidney disease, eye disease, cardiovascular disease, and diabetic foot disease have led to high morbidity and high fatality associated with diabetes (increasing the risk of early death by a factor of 100).
  • People with diabetes in China have chronic complications, and the prevalence rate has reached a fairly high level.
  • hypertension, cardiovascular and cerebrovascular diseases, kidney and eye lesions accounted for about 1/3, and those with neuropathy accounted for more than half.
  • cardiovascular complications is lower than that in Western countries, it has become the chronic complication with the highest disability rate and mortality rate and the greatest harm in China.
  • diabetic microvascular complications and diabetic neurological complications such as kidney and fundus is similar to that in developed countries.
  • Diabetes is one of the common chronic diseases, and the effective means of complete cure is very limited; at present, the most popular treatment is insulin injection. Excessive or too little insulin injection can affect diabetics. At present, there is no use of insulin in the market, and long-term use can significantly improve the functional beverages such as hyperglycemia and hypoglycemia.
  • the object of the present invention is to provide a pure natural functional beverage suitable for drinking by a diabetic based on health promotion, which has stable properties, obvious effects, and can be widely consumed by diabetics.
  • the present invention provides a purely functional beverage suitable for drinking by a diabetic based on health promotion, the functional beverage consisting of the following parts by weight:
  • Green tea extract 0.5 ⁇ 2 servings
  • horse ⁇ tea extract 0.1 ⁇ 0.5 parts
  • guarana extract 0.1 ⁇ 0.5 parts
  • Asian ginseng extract 0.05 ⁇ 0.2 parts
  • acerola cherry extract 0.05 ⁇ 0.2 Serve
  • rosemary extract 0.05 ⁇ 0.2 parts
  • natural flavoring agent 0.5 ⁇ 2 parts
  • natural sweetener 0.5 ⁇ 2 parts, the rest is composed of water.
  • the natural flavoring agent is one or more of guava extract, acai berry extract, dragon fruit extract, cola fruit extract, kiwi fruit extract, blueberry extract;
  • the flavoring agent is one or more of Luo Han Guo extract, stevia extract, and kiwi sweet protein.
  • the functional beverage consists of the following parts by weight:
  • Green tea extract 0.5g, horse ⁇ tea extract: 0.1g, guarana extract: 0.1g, Asian ginseng extract 0.05g, acerola cherry extract: 0.05g, rosemary extract: 0.05g, Guava extract: 0.5 g, Luo Han Guo extract: 0.5 g, water: 98.15 g.
  • the functional beverage consists of the following parts by weight:
  • Green tea extract 2g
  • horse ⁇ tea extract 0.5g
  • guarana extract 0.5g
  • Asian ginseng extract 0.2g
  • acerola cherry extract 0.2g
  • rosemary extract 0.2g
  • singular Fruit extract 2 g
  • stevia extract 2 g
  • water 92.4 g.
  • the functional beverage consists of the following parts by weight:
  • Green tea extract 1 g
  • horse ⁇ tea extract 0.5 g
  • guarana extract 0.1 g
  • Asian ginseng extract 0.1 g
  • acerola cherry extract 0.1 g
  • rosemary extract 0.1 g
  • Pomegranate extract 0.5 g
  • stevia extract 1 g
  • water 96.6 g.
  • the rosemary extract is used as a natural preservative.
  • the functional beverage consists of the following parts by weight:
  • Green tea extract 0.5g, horse ⁇ tea extract: 0.1g, guarana extract: 0.1g, Asian ginseng extract 0.05g, acerola cherry extract: 0.05g, rosemary extract: 0.05g, Guava extract: 0.5 g, Luo Han Guo extract: 0.5 g, water: 98.15 g.
  • the functional beverage consists of the following parts by weight:
  • Green tea extract 2g
  • horse ⁇ tea extract 0.5g
  • guarana extract 0.5g
  • Asian ginseng extract 0.2g
  • acerola cherry extract 0.2g
  • rosemary extract 0.2g
  • singular Fruit extract 2 g
  • stevia extract 2 g
  • water 92.4 g.
  • the functional beverage consists of the following parts by weight:
  • Green tea extract 1 g
  • horse ⁇ tea extract 0.5 g
  • guarana extract 0.1 g
  • Asian ginseng extract 0.1 g
  • acerola cherry extract 0.1 g
  • rosemary extract 0.1 g
  • Pomegranate extract 0.5 g
  • stevia extract 1 g
  • water 96.6 g.
  • the present invention also provides a method for preparing a pure natural functional beverage suitable for drinking by a diabetic based on health promotion, the preparation method comprising the following steps:
  • Green tea extract, mate tea extract, guarana extract, Asian ginseng extract, acerola cherry extract, rosemary extract, natural flavoring agent, natural sweetener and water are preset. Mixing and mixing at room temperature;
  • step B The mixture formed in the step A is centrifuged at a high speed, and the separated liquid is reserved;
  • step B the separation liquid formed in step B is homogenized by a homogenizer to obtain a homogeneous liquid, the homogenization pressure is 25Mpa;
  • the homogenized liquid is filtered and sterilized by using a microporous membrane to obtain a functional beverage.
  • the pore size of the microporous membrane is from 0.88 to 0.22 ⁇ m.
  • the functional beverage provided by the invention not only targets a special group of diabetics, but also plays a preventive role for normal human consumption.
  • the invention adopts the health management cloud platform system to perform blood glucose tracking records and data analysis on the patients taking the beverage, and the analysis results show that the long-term use of the functional beverage can actually stabilize blood sugar, thereby approaching and reaching the normal range.
  • the functional beverage provided by the invention adopts the following ratio:
  • Green tea extract 0.5 ⁇ 2 servings
  • horse ⁇ tea extract 0.1 ⁇ 0.5 parts
  • guarana extract 0.1 ⁇ 0.5 parts
  • Asian ginseng extract 0.05 ⁇ 0.2 parts
  • acerola cherry extract 0.05 ⁇ 0.2 Serve
  • rosemary extract 0.05 ⁇ 0.2 parts
  • natural flavoring agent 0.5 ⁇ 2 parts
  • natural sweetener 0.5 ⁇ 2 parts, the rest is composed of water.
  • the green tea extract has the pharmacological effects of clearing away heat, eliminating phlegm, eliminating phlegm, relieving thirst, reducing fire and improving eyesight;
  • the extract of horse scented tea has the effect of refreshing the nerves, clearing the intestines, and light body nourishing and descending.
  • lipid depressurization the chemical composition of Guarana extract is similar to caffeine, and it will have a feeling of mental and physical strength after taking Guarana; the extract of Asian ginseng has great vitality, complex veins, spleen Yifei, Shengjinzhike, soothe the nerves and other effects; acerola cherry extract is rich in vitamin C, also contains vitamin A, B1, B2, E, P, nicotinic acid, anti-aging factor (SOD), calcium, iron , a variety of nutrients such as zinc, potassium and protein; rosemary extract has the effect of strengthening liver function and lowering blood sugar.
  • SOD anti-aging factor
  • the functional beverages made from the above components have the thirst, the light body, the refreshing, The effect of lowering blood sugar, therefore, diabetics can drink the beverage without worrying about the danger of excessive sugar, and the diabetics drink the functional beverage made of the above components for a long time, which can play a therapeutic role and lower blood sugar.
  • the natural flavoring agent is one or more of guava extract, acai berry extract, dragon fruit extract, cola fruit extract, kiwi fruit extract, blueberry extract, etc.; natural flavor
  • the agent is an extract extracted from the above-mentioned fruits having different flavors, and the natural flavoring agent is healthier, and the harm of the existing chemical synthetic flavoring agent to the drinker can be avoided.
  • the natural sweetener is one or more of Luo Han Guo extract, stevia extract, kiwi sweet protein, etc.
  • the natural sweetener is a pure natural extract, the sweetness is significantly higher than the sucrose sweetness, and does not contain any Calories, which do not affect blood sugar levels or interfere with insulin, can give diabetics more flexibility in terms of total calorie intake and help control weight, which can be used to help treat diabetes.
  • the natural sweet taste component contained in the functional beverage does not increase the glucose content in the blood, and can effectively solve the diabetic person's dependence on the sweet food.
  • the functional calorie calorie value is zero, which does not add extra exercise burden to diabetics.
  • the rosemary extract can be used as a natural preservative to ensure the shelf life of the functional beverage.
  • Green tea extract 0.5g, horse ⁇ tea extract: 0.1g, guarana extract: 0.1g, Asian ginseng extract 0.05g, acerola cherry extract: 0.05g, rosemary extract: 0.05g, Guava extract: 0.5 g, Luo Han Guo extract: 0.5 g, water: 98.15 g.
  • Green tea extract 2g
  • horse ⁇ tea extract 0.5g
  • guarana extract 0.5g
  • Asian ginseng extract 0.2g
  • acerola cherry extract 0.2g
  • rosemary extract 0.2g
  • singular Fruit extract 2 g
  • stevia extract 2 g
  • water 92.4 g.
  • Green tea extract 1 g
  • horse ⁇ tea extract 0.5 g
  • guarana extract 0.1 g
  • Asian ginseng extract 0.1 g
  • acerola cherry extract 0.1 g
  • rosemary extract 0.1 g
  • Pomegranate extract 0.5 g
  • stevia extract 1 g
  • water 96.6 g.
  • Green tea extract 0.5g, horse ⁇ tea extract: 0.1g, guarana extract: 0.1g, Asian ginseng extract 0.05g, acerola cherry extract: 0.05g, rosemary extract: 0.05g, Guava extract: 2.0 g, Luo Han Guo extract: 0.5 g, water: 96.65 g.
  • Green tea extract 0.5g, horse ⁇ tea extract: 0.1g, guarana extract: 0.1g, Asian ginseng extract 0.05g, acerola cherry extract: 0.05g, rosemary extract: 0.05g, Guava extract: 2.0 g, Luo Han Guo extract: 1.0 g, water: 96.15 g.
  • Green tea extract 0.5g, horse ⁇ tea extract: 0.1g, guarana extract: 0.1g, Asian ginseng extract 0.05g, acerola cherry extract: 0.05g, rosemary extract: 0.05g, Guava extract: 2.0 g, Luo Han Guo extract: 1.5 g, water: 95.65 g.
  • Green tea extract 0.5g, horse ⁇ tea extract: 0.1g, guarana extract: 0.1g, Asian ginseng extract 0.05g, acerola cherry extract: 0.05g, rosemary extract: 0.05g, Guava extract: 2.0 g, Luo Han Guo extract: 2.0 g, water: 95.15 g.
  • Green tea extract 2g
  • horse ⁇ tea extract 0.5g
  • guarana extract 0.5g
  • Asian ginseng extract 0.2g
  • acerola cherry extract 0.2g
  • rosemary extract 0.2g
  • Pomegranate extract 2 g
  • Luo Han Guo extract 2 g
  • water 92.4 g.
  • the health-promoting natural natural functional beverages suitable for diabetics in the above Examples 1-8 were prepared by the following methods:
  • Green tea extract, mate tea extract, guarana extract, Asian ginseng extract, acerola cherry extract, rosemary extract, natural flavoring agent, natural sweetener and water are preset. Mixing and mixing at room temperature;
  • step B The mixture formed in the step A is centrifuged at a high speed, and the separated liquid is reserved;
  • step B the separation liquid formed in step B is homogenized by a homogenizer to obtain a homogeneous liquid, the homogenization pressure is 25Mpa;
  • the homogenized liquid is filtered and sterilized by using a microporous membrane to obtain a functional beverage.
  • the pore diameter of the microporous membrane may be selected to be 0.88 to 0.22 ⁇ m.
  • the detailed operation of filtering and sterilizing using the microporous membrane in the above step D is as follows:
  • the filter membrane with a pore size of 0.22 ⁇ m was placed in a clean plastic filter, screwed and flattened, and packaged and sterilized (0. lMPa, sterilized at 121.5 ° C for 20 min).
  • the inlet of the sterilized plastic filter is aseptically attached to a syringe containing the solution to be filtered, the needle is attached to the outlet and inserted into a sterile test tube with a rubber stopper.
  • the solution to be filtered in the syringe is pressurized and slowly squeezed into a sterile test tube, filtered, and the needle is dispensed.
  • the force should be appropriate, not too fast and too fast, so as to prevent bacteria from passing.
  • the whole process should be strictly aseptically operated under aseptic conditions to prevent contamination. Leakage at each joint should be avoided during filtration.
  • the clinical trial conducted a clinical validation test on 75 users through the health management cloud platform.
  • the average daily consumption of the functional beverage was 200 ml.
  • the average range of blood glucose before taking the dose was based on the comparison of the population.
  • the test results are as follows:
  • Diabetes population 1 (15 people) 8.5 7.8 6.9 6.5
  • Diabetes population 2 (15 people) 10.1 9.5 8.4 7.7
  • normal human venous fasting blood glucose is in the range of 4.0-6.0 mmol/l; the diagnosis of diabetes is: venous fasting blood glucose greater than 7.0 mmol/l, or postprandial blood glucose greater than 11.1 mmol/l; hypoglycemia standard is venous fasting blood glucose Less than 2.8mmol / l; impaired glucose tolerance is venous fasting blood glucose in the range of 6.1-6.9mmol / l.

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Abstract

一种适于糖尿病人饮用的功能饮料，所述功能饮料由绿茶提取物0.5-2份、马黛茶提取物0.1-0.5份、瓜拉纳提取物0.1-0.5份、亚洲参提取物0.05-0.2份、针叶樱桃提取物0.05-0.2份、迷迭香提取物0.05-0.2份、天然香味剂0.5-2份、天然甜味剂0.5-2份、水余量组成。制备方法为：将所述组分室温搅拌混合；混合液高速离心，分离液备用；分离液用均质机均质；微孔滤膜对均质液过滤除菌，得功能饮料。

Description

[根据细则37.2由ISA制定的发明名称]　一种适于糖尿病人饮用的功能饮料及其制备方法
技术领域
本发明涉及功能食品技术领域，特别涉及一种基于健康促进的适于糖尿病人饮用的纯天然功能饮料。
背景技术
糖尿病是一种以血葡萄糖水平增高为特征的、严重危害人类健康的慢性非传染性、代谢性疾病。无论是在发达国家还是发展中国家，糖尿病成为现代社会的流行病，已成为严重威胁人类健康的世界性公共卫生问题。WHO统计与预测的结果如下：1994年糖尿病患者人数为1.20亿, 1997年为1.35亿, 2000年为1.75亿, 2010年为2.39亿，2025年预计将突破3亿。而且近三、五十年内糖尿病急剧增加的趋势仍将继续。
糖尿病危害巨大，不仅影响患者的生活质量，而且给患者带来沉重的心理负担。糖尿病所导致的肾病、眼病、心血管疾病和糖尿病足病等并发症，导致了糖尿病相关的高致残率和高致死率（使早死亡风险提高了100倍）。我国糖尿病患者有慢性并发症者相当普遍，患病率已达到相当高的水平。其中合并有高血压、心脑血管病、肾及眼病变者均占1/3左右，有神经病变者占半数以上。心血管并发症的患病率虽较西方国家为低，但已经成为我国糖尿病致残率和致死率最高、危害最大的慢性并发症。肾脏、眼底等糖尿病微血管并发症及糖尿病神经并发症的患病率与发达国家相差无几。
糖尿病作为常见的慢性病之一，完全治愈的有效手段十分有限；目前，最为流行的治疗方法为注射胰岛素。过量或者过少注射胰岛素，对糖尿病人都会造成影响。目前市场上还没有配合胰岛素使用，通过长期服用可明显改善血糖过高、过低等症状的功能饮料。
发明内容
本发明的目的在于提供一种基于健康促进的适于糖尿病人饮用的纯天然功能饮料，性质稳定、效果明显、糖尿病人可广泛饮用。
为实现上述目的，本发明提供一种基于健康促进的适于糖尿病人饮用的纯天然功能饮料，所述功能饮料由以下重量份组分组成：
绿茶提取物：0.5~2份，马黛茶提取物：0.1~0.5份，瓜拉纳提取物：0.1~0.5份，亚洲参提取物：0.05~0.2份，针叶樱桃提取物：0.05~0.2份，迷迭香提取物：0.05~0.2份；天然香味剂：0.5~2份；天然甜味剂：0.5~2份，其余组成为水。
优选地，所述天然香味剂为番石榴提取物、巴西莓提取物、火龙果提取物、可乐果提取物、奇异果提取物、蓝莓提取物中的一种或几种；所述天然甜味剂为罗汉果提取物、甜叶菊提取物、奇异果甜蛋白中的一种或几种。
优选地，所述功能饮料由以下重量份组分组成：
绿茶提取物：0.5g、马黛茶提取物：0.1g、瓜拉纳提取物：0.1g、亚洲参提取物0.05g、针叶樱桃提取物：0.05g、迷迭香提取物：0.05g、番石榴提取物：0.5g、罗汉果提取物：0.5g、水：98.15g。
优选地，所述功能饮料由以下重量份组分组成：
绿茶提取物：2g、马黛茶提取物：0.5g、瓜拉纳提取物：0.5g、亚洲参提取物0.2g、针叶樱桃提取物：0.2g、迷迭香提取物：0.2g、奇异果提取物：2g、甜叶菊提取物：2g、水：92.4g。
优选地，所述功能饮料由以下重量份组分组成：
绿茶提取物：1g、马黛茶提取物：0.5g、瓜拉纳提取物：0.1g、亚洲参提取物0.1g、针叶樱桃提取物：0.1g、迷迭香提取物：0.1g、番石榴提取物：0.5g、甜叶菊提取物：1g、水：96.6g。
优选地，所述迷迭香提取物作为天然防腐剂使用。
优选地，所述功能饮料由以下重量份组分组成：
绿茶提取物：0.5g、马黛茶提取物：0.1g、瓜拉纳提取物：0.1g、亚洲参提取物0.05g、针叶樱桃提取物：0.05g、迷迭香提取物：0.05g、番石榴提取物：0.5g、罗汉果提取物：0.5g、水：98.15g。
优选地，所述功能饮料由以下重量份组分组成：
绿茶提取物：2g、马黛茶提取物：0.5g、瓜拉纳提取物：0.5g、亚洲参提取物0.2g、针叶樱桃提取物：0.2g、迷迭香提取物：0.2g、奇异果提取物：2g、甜叶菊提取物：2g、水：92.4g。
优选地，所述功能饮料由以下重量份组分组成：
绿茶提取物：1g、马黛茶提取物：0.5g、瓜拉纳提取物：0.1g、亚洲参提取物0.1g、针叶樱桃提取物：0.1g、迷迭香提取物：0.1g、番石榴提取物：0.5g、甜叶菊提取物：1g、水：96.6g。
此外，为实现上述目的，本发明还提供一种基于健康促进的适于糖尿病人饮用的纯天然功能饮料的制备方法，所述制备方法包含以下步骤：
A、将绿茶提取物、马黛茶提取物、瓜拉纳提取物、亚洲参提取物、针叶樱桃提取物、迷迭香提取物、天然香味剂、天然甜味剂和水按预置的配比室温下搅拌混合；
B、将步骤A中形成的混合液高速离心分离，分离液备用；
C、将步骤B中形成的分离液用均质机均质，得到均质液，均质压力为25Mpa；
D、采用微孔滤膜对均质液进行过滤除菌，得到目的功能饮料。
优选地，所述微孔滤膜的孔径为0.88-0.22μm。
本发明提供的功能饮料不仅仅针对特殊糖尿病人群体，对于正常人饮用来说也可以起到预防的作用。本发明通过健康管理云平台系统，对服用该饮料的病患者进行了血糖跟踪记录与数据分析，分析结果表明长期服用该功能饮料确实可以起到平稳血糖的作用，从而接近并达到正常范围。
具体实施方式
下面结合具体实施例对本发明做进一步的详细说明，以下实施例是对本发明的解释，本发明并不局限于以下实施例。
本发明所提供的功能饮料，采用如下配比：
绿茶提取物：0.5~2份，马黛茶提取物：0.1~0.5份，瓜拉纳提取物：0.1~0.5份，亚洲参提取物：0.05~0.2份，针叶樱桃提取物：0.05~0.2份，迷迭香提取物：0.05~0.2份；天然香味剂：0.5~2份；天然甜味剂：0.5~2份，其余组成为水。
在上述组分中，绿茶提取物具有清热解暑、消食化痰、生津止渴、降火明目等药理作用；马黛茶提取物具有提神安神、清肠解腻、轻体养肤、降脂降压等功效；瓜拉纳提取物的化学成份类似于咖啡因，在服用瓜拉纳后会有精神和体力充沛的感觉；亚洲参提取物具有大补元气，复脉固脱，补脾益肺，生津止渴，安神益智等功效；针叶樱桃提取物富含维生素C，还含有维生素A、B1、B2、E、P、烟碱酸、抗衰老因子（SOD）、钙、铁、锌、钾和蛋白质等多种营养物质；迷迭香提取物具有强化肝脏功能，降低血糖的功效。
由于糖尿病人在临床的表现为多饮、多尿、多食和消瘦等症状，以及疲乏无力等，而采用上述组分制成的功能饮料，具有生津止渴、轻体养肤、提神安神、降低血糖的功效，因此，糖尿病人可以饮用该饮料而不用担心糖分过高的危害，并且糖尿病人长期饮用采用上述组分制成的功能饮料，可起到治疗作用，可降低血糖。
在上述实施例中，天然香味剂为番石榴提取物、巴西莓提取物、火龙果提取物、可乐果提取物、奇异果提取物、蓝莓提取物等中的一种或几种；天然香味剂为从具有不同香味的上述水果中所提取的提取物，采用天然香味剂更为健康，可避免现有的化学合成香味剂给饮用者带来的危害。天然甜味剂为罗汉果提取物、甜叶菊提取物、奇异果甜蛋白等中的一种或几种，天然甜味剂是纯天然的提取物，甜度明显高于蔗糖甜度，不含任何卡路里，不会影响血糖水平或干扰胰岛素，可以给糖尿病人在预算总摄入热量方面提供更多灵活选择，并有助于控制体重，可以用来辅助治疗糖尿病。同时，所述功能饮料中含有的天然甜味成分不会增加血液中葡萄糖含量，可以有效解决糖尿病人对甜食的依赖感。此外，功能饮料的卡路里热量值为零，不会给糖尿病人增加额外的运动负担。
在上述实施例中，迷迭香提取物可以作为天然防腐剂使用，以保证功能饮料的食用保质期。
实施例1
基于健康促进的适于糖尿病人饮用的纯天然功能饮料的组分如下：
绿茶提取物：0.5g、马黛茶提取物：0.1g、瓜拉纳提取物：0.1g、亚洲参提取物0.05g、针叶樱桃提取物：0.05g、迷迭香提取物：0.05g、番石榴提取物：0.5g、罗汉果提取物：0.5g、水：98.15g。
实施例2
基于健康促进的适于糖尿病人饮用的纯天然功能饮料的组分如下：
绿茶提取物：2g、马黛茶提取物：0.5g、瓜拉纳提取物：0.5g、亚洲参提取物0.2g、针叶樱桃提取物：0.2g、迷迭香提取物：0.2g、奇异果提取物：2g、甜叶菊提取物：2g、水：92.4g。
实施例3
基于健康促进的适于糖尿病人饮用的纯天然功能饮料的组分如下：
绿茶提取物：1g、马黛茶提取物：0.5g、瓜拉纳提取物：0.1g、亚洲参提取物0.1g、针叶樱桃提取物：0.1g、迷迭香提取物：0.1g、番石榴提取物：0.5g、甜叶菊提取物：1g、水：96.6g。
实施例4
基于健康促进的适于糖尿病人饮用的纯天然功能饮料的组分如下：
绿茶提取物：0.5g、马黛茶提取物：0.1g、瓜拉纳提取物：0.1g、亚洲参提取物0.05g、针叶樱桃提取物：0.05g、迷迭香提取物：0.05g、番石榴提取物：2.0g、罗汉果提取物：0.5g、水：96.65g。
实施例5
基于健康促进的适于糖尿病人饮用的纯天然功能饮料的组分如下：
绿茶提取物：0.5g、马黛茶提取物：0.1g、瓜拉纳提取物：0.1g、亚洲参提取物0.05g、针叶樱桃提取物：0.05g、迷迭香提取物：0.05g、番石榴提取物：2.0g、罗汉果提取物：1.0g、水：96.15g。
实施例6
基于健康促进的适于糖尿病人饮用的纯天然功能饮料的组分如下：
绿茶提取物：0.5g、马黛茶提取物：0.1g、瓜拉纳提取物：0.1g、亚洲参提取物0.05g、针叶樱桃提取物：0.05g、迷迭香提取物：0.05g、番石榴提取物：2.0g、罗汉果提取物：1.5g、水：95.65g。
实施例7
基于健康促进的适于糖尿病人饮用的纯天然功能饮料的组分如下：
绿茶提取物：0.5g、马黛茶提取物：0.1g、瓜拉纳提取物：0.1g、亚洲参提取物0.05g、针叶樱桃提取物：0.05g、迷迭香提取物：0.05g、番石榴提取物：2.0g、罗汉果提取物：2.0g、水：95.15g。
实施例8
基于健康促进的适于糖尿病人饮用的纯天然功能饮料的组分如下：
绿茶提取物：2g、马黛茶提取物：0.5g、瓜拉纳提取物：0.5g、亚洲参提取物0.2g、针叶樱桃提取物：0.2g、迷迭香提取物：0.2g、番石榴提取物：2g、罗汉果提取物：2g、水：92.4g。
以上实施例1-8中的基于健康促进的适于糖尿病人饮用的纯天然功能饮料均采用下述方法制备：
A、将绿茶提取物、马黛茶提取物、瓜拉纳提取物、亚洲参提取物、针叶樱桃提取物、迷迭香提取物、天然香味剂、天然甜味剂和水按预置的配比室温下搅拌混合；
B、将步骤A中形成的混合液高速离心分离，分离液备用；
C、将步骤B中形成的分离液用均质机均质，得到均质液，均质压力为25Mpa；
D、采用微孔滤膜对均质液进行过滤除菌，得到目的功能饮料。
上述实施例中，微孔滤膜的孔径可以选择为0.88-0.22μm。上述步骤D中采用微孔滤膜将过滤除菌的详细操作如下：
（1）组装、灭菌；
将0.22μm孔径的滤膜装入清洗干净的塑料滤器中，旋紧压平，包装灭菌后待用（0.lMPa，121.5℃灭菌20min）。
（2）连接；
在无菌条件下，将灭菌后的塑料滤器的入口以无菌操作方式连接于装有待滤溶液的注射器上，将针头与出口处连接并插入带橡皮塞的无菌试管中。
（3）压滤；
将注射器中的待滤溶液加压并缓缓挤入过滤到无菌试管中，滤毕，将针头拨出。压滤时，用力要适当，不可太猛太快，以免细菌通过。
（4）无菌检查；
无菌操作吸取无菌试管中的除菌滤液0.1ml于肉汤蛋白胨平板上，涂布均匀，置37℃温室中培养24h，检查是否有菌生长。
（5）清洗；
弃去塑料滤器上的微孔滤膜，将塑料滤器清洗干净，并换上一张新的微孔滤膜，组装包扎，再经无菌后使用。
整个过程应在无菌条件下严格无菌操作，以防污染，过滤时应避免各连接处出现渗漏现象。
临床试验通过健康管理云平台，对75名体验者进行临床验证试验，平均每日服用该功能饮料200ml，以服用前血糖值平均范围为依照人群对比，每次静脉检测空腹血糖，三次取平均值（每月按30天计算取平均值）。试验结果如下表：
血糖浓度 血糖平均值浓度（mmol/l）
组别 饮用前 第一个月 第二个月 第三个月
正常人群（15人） 5.1 5.1 5.0 5.0
低血糖人群（15人） 3.9 4.0 4.3 4.6
糖耐量受损人群（15人） 6.5 6.0 5.3 5.2
糖尿病人群1（15人） 8.5 7.8 6.9 6.5
糖尿病人群2（15人） 10.1 9.5 8.4 7.7
如上表中，正常人静脉空腹血糖在4.0-6.0mmol/l范围；确诊为糖尿病标准为：静脉空腹血糖大于7.0mmol/l，或餐后血糖大于11.1mmol/l；低血糖标准为静脉空腹血糖小于2.8mmol/l；糖耐量受损标准为静脉空腹血糖在6.1-6.9mmol/l。通过对糖尿病不同阶段人群的考察，可以发现该功能饮料具有明显的使血糖趋于平稳并接近正常值范围的功效。
以上仅为本发明的优选实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书及附图内容所作的等效结构或等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围内。

Claims (11)

  1. 一种基于健康促进的适于糖尿病人饮用的纯天然功能饮料，其特征在于，所述功能饮料由以下重量份组分组成：
    绿茶提取物：0.5~2份，马黛茶提取物：0.1~0.5份，瓜拉纳提取物：0.1~0.5份，亚洲参提取物：0.05~0.2份，针叶樱桃提取物：0.05~0.2份，迷迭香提取物：0.05~0.2份；天然香味剂：0.5~2份；天然甜味剂：0.5~2份，其余组成为水。
  2. 如权利要求1所述的基于健康促进的适于糖尿病人饮用的纯天然功能饮料，其特征在于，所述天然香味剂为番石榴提取物、巴西莓提取物、火龙果提取物、可乐果提取物、奇异果提取物、蓝莓提取物中的一种或几种；所述天然甜味剂为罗汉果提取物、甜叶菊提取物、奇异果甜蛋白中的一种或几种。
  3. 如权利要求2所述的基于健康促进的适于糖尿病人饮用的纯天然功能饮料，其特征在于，所述功能饮料由以下重量份组分组成：
    绿茶提取物：0.5g、马黛茶提取物：0.1g、瓜拉纳提取物：0.1g、亚洲参提取物0.05g、针叶樱桃提取物：0.05g、迷迭香提取物：0.05g、番石榴提取物：0.5g、罗汉果提取物：0.5g、水：98.15g。
  4. 如权利要求2所述的基于健康促进的适于糖尿病人饮用的纯天然功能饮料，其特征在于，所述功能饮料由以下重量份组分组成：
    绿茶提取物：2g、马黛茶提取物：0.5g、瓜拉纳提取物：0.5g、亚洲参提取物0.2g、针叶樱桃提取物：0.2g、迷迭香提取物：0.2g、奇异果提取物：2g、甜叶菊提取物：2g、水：92.4g。
  5. 如权利要求2所述的基于健康促进的适于糖尿病人饮用的纯天然功能饮料，其特征在于，所述功能饮料由以下重量份组分组成：
    绿茶提取物：1g、马黛茶提取物：0.5g、瓜拉纳提取物：0.1g、亚洲参提取物0.1g、针叶樱桃提取物：0.1g、迷迭香提取物：0.1g、番石榴提取物：0.5g、甜叶菊提取物：1g、水：96.6g。
  6. 如权利要求2所述的基于健康促进的适于糖尿病人饮用的纯天然功能饮料，其特征在于，所述迷迭香提取物作为天然防腐剂使用。
  7. 如权利要求6所述的基于健康促进的适于糖尿病人饮用的纯天然功能饮料，其特征在于，所述功能饮料由以下重量份组分组成：
    绿茶提取物：0.5g、马黛茶提取物：0.1g、瓜拉纳提取物：0.1g、亚洲参提取物0.05g、针叶樱桃提取物：0.05g、迷迭香提取物：0.05g、番石榴提取物：0.5g、罗汉果提取物：0.5g、水：98.15g。
  8. 如权利要求6所述的基于健康促进的适于糖尿病人饮用的纯天然功能饮料，其特征在于，所述功能饮料由以下重量份组分组成：
    绿茶提取物：2g、马黛茶提取物：0.5g、瓜拉纳提取物：0.5g、亚洲参提取物0.2g、针叶樱桃提取物：0.2g、迷迭香提取物：0.2g、奇异果提取物：2g、甜叶菊提取物：2g、水：92.4g。
  9. 如权利要求6所述的基于健康促进的适于糖尿病人饮用的纯天然功能饮料，其特征在于，所述功能饮料由以下重量份组分组成：
    绿茶提取物：1g、马黛茶提取物：0.5g、瓜拉纳提取物：0.1g、亚洲参提取物0.1g、针叶樱桃提取物：0.1g、迷迭香提取物：0.1g、番石榴提取物：0.5g、甜叶菊提取物：1g、水：96.6g。
  10. 一种基于健康促进的适于糖尿病人饮用的纯天然功能饮料的制备方法，其特征在于，所述制备方法包含以下步骤：
    A、将绿茶提取物、马黛茶提取物、瓜拉纳提取物、亚洲参提取物、针叶樱桃提取物、迷迭香提取物、天然香味剂、天然甜味剂和水按预置的配比室温下搅拌混合；
    B、将步骤A中形成的混合液高速离心分离，分离液备用；
    C、将步骤B中形成的分离液用均质机均质，得到均质液，均质压力为25Mpa；
    D、采用微孔滤膜对均质液进行过滤除菌，得到目的功能饮料。
  11. 如权利要求10所述的基于健康促进的适于糖尿病人饮用的纯天然功能饮料的制备方法，其特征在于，所述微孔滤膜的孔径为0.88-0.22μm。
PCT/CN2015/070208 2014-12-26 2015-01-06 一种适于糖尿病人饮用的功能饮料及其制备方法 Ceased WO2016101347A1 (zh)

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