WO2016080942A1 - Method for obtaining a pasty form of sorbent based on hydrogel o methylsilicic acid - Google Patents

Method for obtaining a pasty form of sorbent based on hydrogel o methylsilicic acid Download PDF

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Publication number
WO2016080942A1
WO2016080942A1 PCT/UA2016/000003 UA2016000003W WO2016080942A1 WO 2016080942 A1 WO2016080942 A1 WO 2016080942A1 UA 2016000003 W UA2016000003 W UA 2016000003W WO 2016080942 A1 WO2016080942 A1 WO 2016080942A1
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WO
WIPO (PCT)
Prior art keywords
hydrogel
methylsilicic acid
sorbent
obtaining
methylsilicic
Prior art date
Application number
PCT/UA2016/000003
Other languages
English (en)
French (fr)
Inventor
Yuriy Zakharovych TOLCHEYEV
Original Assignee
Tolcheyev Yuriy Zakharovych
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tolcheyev Yuriy Zakharovych filed Critical Tolcheyev Yuriy Zakharovych
Publication of WO2016080942A1 publication Critical patent/WO2016080942A1/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3021—Milling, crushing or grinding

Definitions

  • the invention relates to a medical industry and refers to a method of obtaining organosilicon adsorbent in the form of paste, which can be used in medicine as enterosorbent to eliminate organic and toxic metabolites, in particularly having high molecular weight.
  • Activated charcoal has been widely used as sorbent. (VIDAL Guideline. Medicinal products in Russia. - M.: OVPEE - Astra Pharm Service, 2000. - P.E-8). It is convenient to use, as it is produced in the form of tablets and powder and is used in chemical, food, pharmaceutical industry, as well as medicine.
  • activated charcoal has significant deficiencies: small sorption activity and low selectivity of the sorption action, e.g., to cholesterol, bilirubin, urea, uric acid, which are usually removed from the body by excretory organs.
  • the tablet form is convenient, but does not allow the intake of the required amount of sorbent per single administration: achievement of a therapeutic effect requires doses of 5-15 g, which corresponds to 25-75 tablets, which is naturally difficult for the patient to take at a time.
  • activated charcoal in powder form is also difficult because it is dewetting or insoluble in water.
  • Activated charcoal is contraindicated in ulcerative lesions of the gastrointestinal tract, stomach bleeding, for children.
  • MCC microcrystalline cellulose
  • Deficiencies unpleasant taste, gastrointestinal discomfort (constipation).
  • Silicon dioxide powder has certain sorptive abilities .
  • Polysorb inorganic multifunctional enterosorbent based on a highly dispersed silicon dioxide.
  • the powder is used to prepare a suspension for oral administration.
  • the use of drugs or food supplements in powder form is usually associated with great inconvenience compared with their use in a tablet form.
  • RU,2234931 discloses an enterosorbent containing silicon dioxide in a tablet form.
  • this enterosorbent contains lignin hydrolyzed and microcrystalline cellulose, which also have adsorption properties, as well as excipients used to obtain tablets, such as pectin, starch, and magnesium or calcium stearate.
  • enterosorbent as a product of nonlinear condensation of methylsilicic acid (the chemical name - polymethylsiloxane polyhydrate), known under the trademark name- "Enterosgel” produced in a gel form.
  • Various raw materials can be used as a source for gel synthesis.
  • WO2011/075095 a method of obtaining methylsilicic acid hydrogel from methylethoxy silane (MTES) and aqueous ethanol with a volume portion of ethyl alcohol of 60 to 96.5%, which is treated with a hydro lyzing blend of hydrochloric acid and purified water.
  • MTES methylethoxy silane
  • aqueous ethanol with a volume portion of ethyl alcohol of 60 to 96.5%
  • RU 2111979 discloses a method of obtaining an enterosorbent based on methylsilicic acid hydrogel as an adsorbent of medium molecular weight metabolites.
  • Medium molecular weight metabolites are substances with a molecular weight of about 500-5000 Da; usually these are protein decomposition products that play an important role in intoxication phenomena.
  • methylsilicic acid compounds According to the author's experiments, the ability of methylsilicic acid compounds to have affinity for substances of a particular mass depends on the physical state and particle size of the sorbent, as well as the solvent itself.
  • WO 2008/036056 discloses a method of obtaining a sorbent based on methylsilicic acid hydrogel, where the sorbent with the general formula
  • ⁇ (CH 3 SiOi.5)-nH 2 0 ⁇ can be produced as paste by varying n ratio, but the concrete Examples for obtaining such form are not described.
  • the main object of the invention is obtaining a pasty form of the sorbent based on hydrogel of methylsilicic acid having a pronounced sorption properties in relation to high molecular weight substances.
  • This object is achieved by the method wherein the synthesized hydrogel of methylsilicic acid is subjected to an additional mechanical processing, preferably in a rotor-type homogenizer, in a solvent for grinding of particles contained in the product to the desired size, preferably to the size of 10-200 ⁇ .
  • water or sugar syrup may be used as the solvent.
  • Target product output 36.7 70-85 %
  • Adsorption activity (A) of the product, ⁇ /g was calculated by the formula:
  • Adsorption activity for high molecular weight substances - immunoglobulin G (more than 100 000 Da) and bacterial toxin (more than 10 000 Da) was measured similarly).
  • the pasty sorbent shows more marked activity in relation to high molecular weight compound, exceeding that of the gel in 1.5-1.83 times.
  • Average particle size and adsorption activity was determined under the microscope.
  • Particle size was 200 ⁇ , adsorption activity by methylene blue - 3.2 ⁇ /g, immunoglobulin G - 330.1 mg/g.
  • Average particle size and adsorption activity was determined under the microscope.
  • Particle size was 10 ⁇ , adsorption activity by methylene blue - 3.6 ⁇ /g, immunoglobulin G - 333.2 mg/g.
  • Particle size was 10 ⁇ , adsorption activity by methylene blue - 3.0 ⁇ /g, immunoglobulin G - 330.1 mg/g.
  • Average particle size and adsorption activity was determined under the microscope.
  • Particle size was 10 ⁇ , adsorption activity by methylene blue - 2.7 ⁇ /g, immunoglobulin G - 318.1 mg/g.
  • the pasty form of the sorbent based on methylsilicic acid hydrogel and obtained by the claimed method additionally has pronounced sorption properties in relation to high molecular weight substances.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
PCT/UA2016/000003 2014-11-20 2016-01-12 Method for obtaining a pasty form of sorbent based on hydrogel o methylsilicic acid WO2016080942A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
UAA201412487A UA112474C2 (uk) 2014-11-20 2014-11-20 Спосіб одержання пастоподібного сорбенту на основі гідрогелю метилкремнієвої кислоти
UAA201412487 2014-11-20

Publications (1)

Publication Number Publication Date
WO2016080942A1 true WO2016080942A1 (en) 2016-05-26

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PCT/UA2016/000003 WO2016080942A1 (en) 2014-11-20 2016-01-12 Method for obtaining a pasty form of sorbent based on hydrogel o methylsilicic acid

Country Status (3)

Country Link
RU (1) RU2014151576A (uk)
UA (1) UA112474C2 (uk)
WO (1) WO2016080942A1 (uk)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2111979C1 (ru) 1994-03-11 1998-05-27 Юрий Николаевич Шевченко Гидрогели метилкремневой кислоты как адсорбенты среднемолекулярных метаболитов и способ их получения
RU2234931C2 (ru) 2002-07-29 2004-08-27 Пермская государственная фармацевтическая академия Композиционный энтеросорбент и способ его приготовления
WO2008036056A1 (fr) 2006-09-20 2008-03-27 Zakryte Aktsionerne Tovarystvo 'ekologoohoronna Firma 'kreoma-Farm' Procédé de fabrication d'un sorbant à base d'un hydrogel d'acide méthylsilicilique
WO2011075095A1 (ru) 2009-12-16 2011-06-23 Kabachnyi Gennadii Ivanovych Способ получения гидрогеля метилкремниевой кислоты
US20130129659A1 (en) * 2011-11-23 2013-05-23 Vadim Kozlovskyi Composite enterosorbent

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2111979C1 (ru) 1994-03-11 1998-05-27 Юрий Николаевич Шевченко Гидрогели метилкремневой кислоты как адсорбенты среднемолекулярных метаболитов и способ их получения
RU2234931C2 (ru) 2002-07-29 2004-08-27 Пермская государственная фармацевтическая академия Композиционный энтеросорбент и способ его приготовления
WO2008036056A1 (fr) 2006-09-20 2008-03-27 Zakryte Aktsionerne Tovarystvo 'ekologoohoronna Firma 'kreoma-Farm' Procédé de fabrication d'un sorbant à base d'un hydrogel d'acide méthylsilicilique
EP2075276A1 (en) * 2006-09-20 2009-07-01 Zakryte Aktsionerne Tovarystvo "Ekologoohoronna" Firma "Kreoma-Farm" Method for producing a sorbent based on a methyl- silicic acid hydrogel
WO2011075095A1 (ru) 2009-12-16 2011-06-23 Kabachnyi Gennadii Ivanovych Способ получения гидрогеля метилкремниевой кислоты
US20130129659A1 (en) * 2011-11-23 2013-05-23 Vadim Kozlovskyi Composite enterosorbent

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Marketing Authorization of the Ministry of Health of the Russian Federation P 97.128.5", STATE REGISTRY OF MEDICINAL PRODUCTS, 2000, pages 102
"VIDAL Guideline. Medicinal products in Russia", M.: OVPEE - ASTRA PHARM SERVICE, 2000
YASHINA ET AL: "Sol-Gel Technology of the Mesoporous Methylsilicic Acid Hydrogel: Medicine Aspects of Globular Porous Organosilicon Materials Application", PROCEEDINGS OF THE NATO ADVANCED RESEARCH WORKSHOP ON SOL-GEL APPROACHES TO MATERIALS FOR POLLUTION CONTROL, WATER PURIFICATION AND SOIL REMEDIATION, KYIV, UKRAINE, 25 - 27 OCTOBER 2007,, 2008, pages 481 - 488, XP009169386, ISBN: 978-1-4020-8522-2 *

Also Published As

Publication number Publication date
RU2014151576A (ru) 2016-07-10
UA112474C2 (uk) 2016-09-12

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