WO2016080509A1 - 検体希釈用容器 - Google Patents
検体希釈用容器 Download PDFInfo
- Publication number
- WO2016080509A1 WO2016080509A1 PCT/JP2015/082641 JP2015082641W WO2016080509A1 WO 2016080509 A1 WO2016080509 A1 WO 2016080509A1 JP 2015082641 W JP2015082641 W JP 2015082641W WO 2016080509 A1 WO2016080509 A1 WO 2016080509A1
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- WIPO (PCT)
- Prior art keywords
- container
- present
- dilution
- specimen
- width
- Prior art date
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
- B01F31/651—Mixing by successively aspirating a part of the mixture in a conduit, e.g. a piston, and reinjecting it through the same conduit into the receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0851—Bottom walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0858—Side walls
Definitions
- the present invention relates to a specimen dilution container for biological sample analysis.
- Patent Document 1 includes an inlet for supplying a dilution solution at the top for diluting a blood sample, and an inlet for injecting air for stirring the liquid at the bottom.
- a liquid mixing container having a roughened surface is disclosed.
- Patent Document 2 discloses a system for diluting and mixing a specimen by discharging a specimen such as blood and a diluent into a container, and repeatedly aspirating and discharging the liquid in the container using a liquid dispensing means.
- Patent Document 3 discloses a centrifugal stirring cuvette having a reagent storage section at the bottom and a pocket having an inclined wall at a part of the side wall.
- JP 2003-161675 A JP-A-10-62432 JP-A-4-348250
- An object of the present invention is to provide means for preparing a diluted solution of a biological sample (specimen) used for biological sample analysis.
- the present invention provides a specimen dilution container capable of simply mixing a small amount of a liquid biological sample and a dilution solution.
- the present invention is a specimen dilution container, An opening opening upward, The first bottom, A second bottom formed on the inner wall of the container; and a groove formed upward from the second bottom on the inner wall of the container;
- the groove has a constant width of the same size as the width of the second bottom or the width of the lower end is the same size as the width of the second bottom and widens upward;
- a specimen dilution container is provided.
- the specimen dilution container of the present invention further includes an opened window formed at an upper end portion of the side wall facing the side wall on which the second bottom portion is formed.
- the width and depth of the second bottom of the specimen dilution container of the present invention are 1 to 3 mm, respectively.
- the specimen dilution container of the present invention further includes a lid for closing the opening.
- the lid portion has a hole through which an injection tube for injecting a liquid into the specimen dilution container passes, or a membrane through which the injection tube can be punctured.
- the specimen dilution container of the present invention further includes an engaging member for fastening the container to the rack.
- the present invention includes dropping a biological sample onto the second bottom of the specimen dilution container and injecting a dilution solution into the container into which the biological sample has been dropped.
- a method for preparing a sample dilution is provided.
- a homogeneous dilution of a trace amount of biological sample can be easily prepared by dropping the biological sample onto a specific position of the container. Therefore, the present invention makes it possible to obtain a highly accurate analysis result in biological sample analysis using a small amount of biological sample.
- FIG. 2 is a rear view of the sample dilution container of the present invention shown in FIG. 1.
- the broken line indicates the vertical direction of the container.
- the specimen dilution container of the present invention is a container for preparing a specimen dilution liquid for biological sample analysis such as a blood test. More specifically, the specimen dilution container of the present invention is a container for preparing a biological sample diluent used as a sample for measurement of biological sample analysis.
- biological samples that is, specimens
- diluted in the specimen dilution container of the present invention include blood, serum, plasma, saliva, urine and other body fluids, stool and vomit lysates or suspensions, animal and plant tissues and cells, etc. Liquid biological samples such as lysates or suspensions.
- the specimen dilution container of the present invention is a container having an opening and a bottom (first bottom), and further includes a second bottom formed on the inner wall of the container.
- the second bottom part is a sample holding part for holding the biological sample before being diluted with the diluting solution.
- the biological sample is held there without flowing out from the second bottom portion.
- the dilution solution of the biological sample is injected into the container holding the biological sample in the direction of the side wall provided with the second bottom, the biological sample and the dilution solution are sufficiently mixed.
- a homogeneous biological sample dilution is prepared.
- the size of the specimen dilution container of the present invention can be appropriately changed according to the amount of the dilution solution to be injected.
- the height is about 30 to 50 mm
- the maximum inner diameter is about 10 to 20 mm
- 250 It has a capacity capable of preparing a diluted solution by mixing or stirring about ⁇ 500 ⁇ L of liquid.
- the container of the present invention has a cylindrical shape, an inverted conical shape, a funnel shape, or a combination thereof.
- the container of the present invention may be a self-supporting container, and may have, for example, legs for self-supporting.
- the opening of the sample dilution container of the present invention opens above the container.
- the upper and lower sides of the container refer to an upper side and a lower side when the container is set up with the first bottom part down, respectively.
- the size of the opening of the container of the present invention is an injection tube (including a needle, nozzle, capillary, pipette tip, etc.) for dropping a biological sample on the second bottom or injecting a liquid such as a diluting solution.
- the inside diameter is not particularly limited as long as it can be inserted, but the inside diameter is preferably about 10 to 20 mm.
- the first bottom of the specimen dilution container of the present invention may be a flat bottom, a round bottom, or a shape combining them.
- the second bottom of the sample dilution container of the present invention is a surface formed on the inner wall of the container of the present invention.
- the second bottom is preferably substantially flat, but may be curved.
- the plane is preferably a substantially non-inclined surface, but may be a substantially inclined surface.
- the non-inclined surface refers to a surface orthogonal to the vertical direction of the container of the present invention (or a surface that is substantially horizontal when the container is set up vertically), and the inclined surface is The surface which is not orthogonal to the vertical direction of the container of the present invention.
- the vertical direction of the container of the present invention refers to the major axis direction of the container from the first bottom of the container toward the opening.
- the non-inclined surfaces are surfaces that meet at an angle of 90 ° with respect to the vertical direction of the container of the present invention.
- the substantially inclined surface is an inclined surface that intersects at an angle of 60 ° or more and less than 90 ° with respect to the vertical direction of the container of the present invention, and the inner wall side of the container is higher.
- the second bottom is a curved surface
- the curved surface is preferably the above-described substantially inclined surface, but the entire surface is a convex surface or a concave surface.
- the shape of the surface constituting the second bottom portion is not particularly limited, and examples thereof include a semicircular arc shape, a U shape, a V shape, and a trapezoidal shape that are open inside the container.
- the size of the surface constituting the second bottom may be any size that can hold 1 to 10 ⁇ L of a biological sample, but preferably has a width (W1) of 1 to 3 mm, such as 1 to 2 mm or 2 to 3 mm.
- the depth (D1) is 1 to 3 mm, for example 1 to 2 mm or 2 to 3 mm.
- the width (W1) is 1 to 2 mm and the depth (D1) is 1 to 2 mm or 2 to 3 mm, or the width (W1) is 2 to 3 mm and the depth (D1) is 1 to 2 mm. 2 to 3 mm.
- the width (W1) of the surface constituting the second bottom is the length of a straight line connecting two points where the surface and the inner wall surface of the container are in contact, and constitutes the second bottom.
- the depth of the surface (D1) is the maximum length of the surface in the direction orthogonal to the straight line.
- the second bottom is formed above the first bottom and below the liquid level of the total amount of the dilution solution to be injected so as to obtain a desired dilution ratio.
- it is formed above the first bottom and below the outlet of the injection tube for injecting the diluting solution or the like, more preferably about 3 to 5 mm above the first bottom. .
- the specimen dilution container of the present invention further includes a groove formed on the inner wall from the second bottom portion toward the top of the container. More specifically, the groove is a groove extending along the vertical direction of the container on the inner wall of the container of the present invention with the second bottom as a base, and is open to the inside of the container. Concave with respect to the inner surface. Therefore, preferably, the shape of the groove may be a shape corresponding to the second bottom portion, for example, a semicircular arc shape, a U shape, a V shape, a trapezoidal shape, or the like.
- the groove makes it easier to visually recognize the second bottom when dropping the biological sample onto the second bottom, and allows the tip of the injection tube for dropping the biological sample to reach the second bottom. To make it easier.
- the groove may have a constant width that is the same size as the width of the second bottom portion, but the width of the lower end thereof is the same size as the width of the second bottom portion and becomes wider upward. It may be.
- the width (W2) of the groove is constant from the lower end to the upper end and is preferably 1 to 3 mm, for example 1 to 2 mm or 2 to 3 mm, as is the width of the second bottom.
- the width (W2) of the groove is the same as the width (W1) of the second bottom at the lower end, preferably 1 to 3 mm, more preferably 1 to 2 mm, and gradually widens upward.
- the upper end it can be preferably more than 1 mm to 5 mm, more preferably more than 2 mm to 5 mm.
- the width (W2) of the groove is the same as the width (W1) of the second bottom at the lower end, preferably 2 to 3 mm, gradually widens upward, and preferably exceeds 2 mm at the upper end. It can be ⁇ 6.5 mm, more preferably more than 3 mm to 6.5 mm.
- the length and depth of the groove can vary depending on the shape of the container of the present invention and the thickness of the inner wall.
- the shape of the container of the present invention is an inverted conical shape or a funnel shape
- the groove gradually becomes shallower as it goes upward, and may eventually disappear.
- the shape of the container of the present invention is cylindrical, the depth of the groove may be constant.
- the groove may continue to the opening, but the second bottom is visible from the top of the container, and the tip of the injection tube for dripping the biological sample is As long as the second bottom can be reached, it may end up to a position 10-20 mm below or below the opening.
- the specimen dilution container of the present invention further includes an opened window formed at the upper end of the side wall facing the side wall on which the second bottom is formed.
- the window has no top edge and forms a series of openings connected to the opening of the container of the invention.
- the shape of the window include a quadrangle, a trapezoid, and a semicircular shape, but are not limited to these as long as the second bottom portion can be visually recognized from above the container.
- the size of the window is not particularly limited as long as the second bottom is visible, and may vary depending on the shape of the container of the present invention.
- the maximum value of the width (W3) and the height (H) is used. Is 7 to 15 mm, more preferably 7 to 10 mm.
- the height (H) of the window is the maximum length in the vertical direction of the container of the present invention
- the width (W3) of the window is the maximum length in the direction orthogonal to the height direction. It is.
- the specimen dilution container of the present invention further includes a lid for closing the opening.
- the lid part include a cap, a screw cap, and a lid.
- the lid portion is provided with a hole or a slit in a surface through which the injection tube passes so that an injection tube for injecting a liquid such as a diluting solution can be inserted into the container of the present invention.
- the hole or slit is not particularly limited as long as it has a size and shape through which the injection tube can pass.
- the lid portion may have a membrane through which the injection tube can be punctured on a surface through which the injection tube passes.
- the specimen dilution container of the present invention further includes an engaging member for fastening the container to the rack.
- the shape, size, and arrangement of the engaging member on the container of the present invention are not particularly limited as long as the container of the present invention can be stably fixed to the rack by the engaging member.
- the engaging member is a protrusion or a hook provided on the outer surface of the container of the present invention.
- the engaging member is an elongated protrusion provided on the outer wall along the longitudinal direction of the container of the present invention.
- the container of the present invention fastened to the rack using the engaging member is arranged in a predetermined direction with respect to the rack, if the rack is set at a predetermined position of the analyzer, the container is used in the apparatus. It becomes possible to arrange
- materials for the specimen dilution container and the engaging member of the present invention include polypropylene, polyethylene, polystyrene, polymethyl methacrylate resin, polyethylene terephthalate, polyamide, polybutylene terephthalate, polyacetal, and combinations thereof.
- the container and the engaging member of the present invention are formed by injection molding.
- the lid and the engaging member may be formed integrally with the container of the present invention, or may be connected after being formed separately.
- the engaging member is formed integrally with the container of the present invention.
- examples of the material for the lid of the specimen dilution container of the present invention include linear low density polyethylene, polypropylene, high density polyethylene, low density polyethylene, polyamide, polyacetal, and combinations thereof.
- the material for the injection tube passage surface of the lid is preferably a linear low density polyethylene, polypropylene, high density polyethylene, low density polyethylene, polyamide, polyacetal, or a combination thereof.
- the material of the lid film includes linear low density polyethylene, polypropylene, high density polyethylene, low density polyethylene, polyamide, polyacetal, and combinations thereof.
- the membrane is preferably a thin layer that can be easily punctured by an injection tube.
- the lid and the film are formed by injection molding.
- the dropping of the biological sample into the specimen dilution container of the present invention is preferably performed manually.
- an operator adds a biological sample with a pipette or the like while holding the specimen dilution container of the present invention with one hand.
- the container of this invention can be hold
- the injection of the dilution solution into the specimen dilution container of the present invention may be performed manually or automatically.
- the discharge port of the injection tube for injecting the diluting solution is directed toward the second bottom.
- the discharge of the diluting solution to the second bottom portion using the needle in the side hole can be exemplified.
- the rack containing the container of the present invention is provided with a label for recognition by the container transfer device and the dilution solution injection apparatus. It is preferable.
- the diluted solution of the biological sample (specimen) prepared using the specimen dilution container of the present invention can be directly set in a normal analyzer and subjected to analysis. More preferably, the specimen dilution container of the present invention is set in an analyzer with a biological sample placed therein, and a series of steps from preparation of a biological sample diluent to analysis are automatically or semi-automatically performed in the analyzer. Done. Diluted solutions of biological samples prepared by the specimen dilution container of the present invention can be used in various biological systems such as high performance liquid chromatography devices, biochemical automatic analyzers, blood cell counters, flow cytometry, flow injection devices, particle size measuring devices, etc. It can be applied to sample analysis.
- FIG. 1 shows one embodiment of the specimen dilution container of the present invention.
- 1a and 1b are a top perspective view and a bottom perspective view, respectively, of a specimen dilution container 1 of the present invention.
- a specimen dilution container 1 shown in FIG. 1 is a funnel-shaped container at the bottom and a cylindrical container at the top, and includes an opening 2 that opens upward. From the opening 2, an injection tube for injecting a biological sample or a diluting solution is inserted into the container 1.
- An engaging member 3 is provided on the outer wall of the container 1 along the longitudinal direction of the container of the present invention.
- the container 1 can stand on its own by the legs 4.
- FIG. 2a is a front view of the specimen dilution container 1 of the present invention
- FIG. 2b shows an embodiment of the lid portion 5 of the container 1.
- FIG. The lid 5 has a hole 51 through which an injection tube for injecting a biological sample dilution solution can pass.
- 3a and 3b show a cross-sectional view of the container 1 taken along line AA in FIG. 2a and a cross-sectional view of the container 1 taken along line BB in FIG. 3a, respectively.
- the container 1 comprises a first bottom 6 which is substantially flat bottom.
- FIG. 3 a shows a side sectional view of the second bottom 7 provided on the inner wall of the container 1 and the groove 8 extending upward therefrom.
- FIG. 3 a shows a side sectional view of the second bottom 7 provided on the inner wall of the container 1 and the groove 8 extending upward therefrom.
- FIGS. 3a and 3b shows a front view of the second bottom 7 and the groove 8.
- the second bottom portion 7 shown in FIGS. 3a and 3b is a horizontal plane, and the groove 8 is a groove that becomes wider upward with the second bottom portion 7 as a base.
- the groove 8 has the deepest lower end, gradually becomes shallower upward, and finally disappears.
- 3c and 3d show cross-sectional views of another embodiment of the specimen dilution container 1 of the present invention.
- 3c is a longitudinal sectional view of the container 1
- FIG. 3d is a sectional view of the container 1 taken along the line BB of FIG. 3c.
- the container 1 comprises a first bottom 6 which is substantially flat bottom.
- the second bottom portion 7 provided on the inner wall of the container 1 is a horizontal plane, and the groove 8 is a groove that becomes wider upward with the second bottom portion 7 as a base.
- FIG. 4 shows a rear view of the specimen dilution container 1 of the present invention.
- FIG. 4 shows a window 9 provided at the upper end of the side wall of the container 1. As shown in FIG. 2 a, the window 9 is provided on the side wall opposite to the side wall provided with the second bottom portion 7.
- a window 9 shown in FIG. 4 is a window without an upper edge that is continuous with the opening 2 at the upper end of the container 1.
- FIG. 5 is a conceptual diagram of an operation of dropping a blood sample onto the second bottom 7 of the specimen dilution container 1 of the present invention.
- the operator drops the blood sample 100 on the second bottom 7 by pipetting.
- the pipette tip 101 is inserted from the opening 2, and its tip reaches the second bottom 7.
- the operator can easily recognize the position of the second bottom 7 from the top of the container 1.
- the tip of the pipette tip 101 can easily reach the second bottom portion 7.
- FIG. 6 is a conceptual diagram of an operation for diluting a blood sample in the specimen dilution container 1 of the present invention.
- the blood sample 100 is dropped on the second bottom 7 in the container 1.
- an injection tube 102 for injecting the dilution solution 103 is inserted into the container 1 from the opening 2.
- the diluted dilution solution 103 ishes the blood sample 100 from the second bottom 7.
- the blood sample 100 flowing out into the diluting solution is sufficiently mixed with the diluting solution to prepare a homogeneous blood sample diluting solution 104.
- Test 1 Using the specimen dilution container 1 of the present invention, a diluted solution was prepared from a 3 ⁇ L blood sample by a method or an automatic analyzer. Table 1 shows the peak area value of hemoglobin A0 obtained by analyzing the prepared blood diluted solution by the HPLC method.
- 300 ⁇ L of the dilution solution is discharged in the direction of the blood sample on the second bottom 7, and the discharged mixture of dilution solution and blood is aspirated and discharged five times. Stir well.
- the automatic analyzer includes a horizontal hole needle as a dilution solution injection tube, and the direction of the sample dilution container 1 is fixed by the engaging member 3 provided in the sample dilution container 1. Discharges the diluting solution in the direction of the second bottom 7.
- blood is dropped on the first bottom 6, the second bottom 7, or the side wall opposite to the second bottom 7 of the container 1, and then the second bottom 7 from the lateral hole needle.
- the diluting solution was discharged in the direction of, and the discharged diluting solution and blood mixture was sucked and discharged five times and sufficiently stirred.
Abstract
Description
上方に開口した開口部、
第一の底部、
該容器の内側壁上に形成された第二の底部、および
該容器の内側壁上に、該第二の底部から上方に向かって形成された溝
を備え、
該溝は、該第二の底部の幅と同じサイズの一定の幅を有するか、もしくは下端の幅は該第二の底部の幅と同じサイズでかつ上方に向かって幅広くなっている、
検体希釈用容器を提供する。
本発明の検体希釈用容器1を用いて、3μLの血液試料から用手法または自動分析装置により希釈液を調製した。表1は、調製した血液希釈液をHPLC法により分析して得られた、ヘモグロビンA0のピークエリア値である。用手法による希釈では、ピペットチップを用いて、希釈用溶液300μLを第二の底部7上の血液試料の方向に吐出し、さらに吐出した希釈用溶液と血液の混合物を5回吸引・吐出し、充分に撹拌した。上記自動分析装置は、希釈用溶液の注入管として横穴ニードルを具備し、検体希釈用容器1に設けられた係合部材3により検体希釈用容器1の向きが固定されることから、該横穴ニードルは第二の底部7の方向に希釈用溶液を吐出する。該自動分析装置による希釈では、容器1の第一の底部6、第二の底部7、または第二の底部7に対向する側壁に血液を滴下し、次いで、該横穴ニードルから第二の底部7の方向に希釈用溶液を吐出し、さらに吐出した希釈用溶液と血液の混合物を5回吸引・吐出し、充分に撹拌した。
2 開口部
3 係合部材
4 脚部
5 蓋部
51 穴
6 第一の底部
7 第二の底部(試料保持部)
8 溝
9 窓
100 血液試料
101 ピペットチップ
102 注入管
103 希釈用溶液
104 希釈液
Claims (6)
- 検体希釈用容器であって、
上方に開口した開口部、
第一の底部、
該容器の内側壁上に形成された第二の底部、および
該容器の内側壁上に、該第二の底部から上方に向かって形成された溝
を備え、
該溝は、該第二の底部の幅と同じサイズの一定の幅を有するか、もしくは下端の幅は該第二の底部の幅と同じサイズでかつ上方に向かって幅広くなっている、
検体希釈用容器。 - 前記第二の底部が形成された側壁と対向する側壁の上端部に形成された、開口された窓をさらに備える、請求項1記載の検体希釈用容器。
- 前記第二の底部の幅および奥行が、それぞれ1~3mmである、請求項1又は2のいずれか1項記載の検体希釈用容器。
- 前記開口部を閉じるための蓋部をさらに備える、請求項1~3のいずれか1項記載の検体希釈用容器。
- 前記蓋部が、前記検体希釈用容器に液体を注入するための注入管が通過するための孔、または該注入管が穿刺可能な膜を有する、請求項4記載の検体希釈用容器。
- 前記検体希釈用容器をラックに留めるための係合部材をさらに備える、請求項1~5のいずれか1項記載の検体希釈用容器。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/528,358 US10576472B2 (en) | 2014-11-21 | 2015-11-20 | Container for specimen dilution |
CN201580063152.9A CN107076649A (zh) | 2014-11-21 | 2015-11-20 | 检体稀释用容器 |
EP15860503.0A EP3222987B1 (en) | 2014-11-21 | 2015-11-20 | Container for specimen dilution |
JP2016560296A JP6637901B2 (ja) | 2014-11-21 | 2015-11-20 | 検体希釈用容器 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014236720 | 2014-11-21 | ||
JP2014-236720 | 2014-11-21 |
Publications (1)
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WO2016080509A1 true WO2016080509A1 (ja) | 2016-05-26 |
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PCT/JP2015/082641 WO2016080509A1 (ja) | 2014-11-21 | 2015-11-20 | 検体希釈用容器 |
Country Status (5)
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US (1) | US10576472B2 (ja) |
EP (1) | EP3222987B1 (ja) |
JP (1) | JP6637901B2 (ja) |
CN (1) | CN107076649A (ja) |
WO (1) | WO2016080509A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108780028A (zh) * | 2016-08-17 | 2018-11-09 | 安必思微量血液科学有限公司 | 包括血液采集器以及血液收容器的血液采集器具 |
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WO2019131039A1 (ja) * | 2017-12-26 | 2019-07-04 | 積水メディカル株式会社 | 撹拌子及び撹拌方法 |
Citations (6)
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Also Published As
Publication number | Publication date |
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EP3222987A1 (en) | 2017-09-27 |
US10576472B2 (en) | 2020-03-03 |
JP6637901B2 (ja) | 2020-01-29 |
EP3222987B1 (en) | 2019-04-10 |
JPWO2016080509A1 (ja) | 2017-08-31 |
EP3222987A4 (en) | 2018-05-16 |
CN107076649A (zh) | 2017-08-18 |
US20180043354A1 (en) | 2018-02-15 |
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