WO2016030555A1 - Formulation biocide et/ou phytosanitaire utilisée sous forme d'aérosol à base de substances actives biodégradables non résiduelles - Google Patents

Formulation biocide et/ou phytosanitaire utilisée sous forme d'aérosol à base de substances actives biodégradables non résiduelles Download PDF

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Publication number
WO2016030555A1
WO2016030555A1 PCT/ES2015/070496 ES2015070496W WO2016030555A1 WO 2016030555 A1 WO2016030555 A1 WO 2016030555A1 ES 2015070496 W ES2015070496 W ES 2015070496W WO 2016030555 A1 WO2016030555 A1 WO 2016030555A1
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Prior art keywords
aerosol
formulation according
active substance
propellant
formulation
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PCT/ES2015/070496
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English (en)
Spanish (es)
Inventor
Francisco ALBEROLA CLAVER
Enrique Gómez Hernández
Mar LLUECA JUESAS
Yolanda SANCHIS SILLA
Jorge Eugenio MASIP GARCÍA
Original Assignee
Decco Ibérica Post Cosecha, S.A.U.
Maldoni Shop, S.L.
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Application filed by Decco Ibérica Post Cosecha, S.A.U., Maldoni Shop, S.L. filed Critical Decco Ibérica Post Cosecha, S.A.U.
Priority to CN201580058616.7A priority Critical patent/CN107105644B/zh
Priority to AU2015308369A priority patent/AU2015308369B2/en
Publication of WO2016030555A1 publication Critical patent/WO2016030555A1/fr
Priority to ZA2017/01820A priority patent/ZA201701820B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A01N25/06—Aerosols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B7/00—Preservation or chemical ripening of fruit or vegetables

Definitions

  • the present invention relates to a system of environmental and surface disinfection both in the agri-food industry and in applications in veterinary, domestic, sanitary, institutional or industrial use, as well as the control of post-harvest diseases of fruits and vegetables through use of aerosol application systems, also known as cold fumigation or total discharge.
  • aerosol application systems also known as cold fumigation or total discharge.
  • compositions used in these systems have several disadvantages such as their danger (being oxidizing), as well as the need for them to be ignited under flame, which is associated with the generation of waste as products of combustion of the components used for the production of smoke, as well as, and mainly, because of the high temperatures that are generated, which means that many of the disinfectant, fungicide or biocidal products used cannot be used because they decompose under these conditions.
  • biocides and phytosanitary products used in this task belong to chemical families that have been well known since ancient times (quaternary ammoniums, orthophenylphenol, glutaraldehyde, iodine derivatives, chlorinated derivatives or peroxides, among others).
  • AEROSOL has been determined by scientists to define a physical state. Strictly speaking it refers to a state of suspension of a large number of fine, solid or liquid particles within a gas, preferably air.
  • the term derives from the words aero (from Greek, in the air), and solutio (from Latin, solution). This means a colloidal solution of non-gaseous substances in the air.
  • the technique has used different methods to generate true aerosols within pure physical definition. The most recent and undoubtedly the most "elegant" method of achieving this objective is developed using liquid gases from a spray container under pressure.
  • aerosol technique is based on spraying a mixture of the product to be sprayed with a liquefied gas.
  • the valve When the valve is operated, the expelled component of the liquefied gas evaporates in a very short time, "tearing" the contained product.
  • aerosol products can be subdivided into three different groups:
  • Aerosols in the strict sense, through which it is intended to achieve The finest possible distribution of the active substance and, therefore, requires keeping the particle size of the spray jet as small as possible. Generally, the proportional part of the active solution or suspension does not therefore exceed more than 20% by weight. These aerosols are used, for example, in inhalers, insecticides, air fresheners, etc .;
  • Aerosols which generate foam-like products, whose particles are "coarse” and must perform a surface moisturizing function.
  • These aerosols contain, based on weight, between 30-60% of active substance and are used, for example, in shaving foams, shampoos, detergent foams, etc.
  • the active substance of the formulation can be differentiated as follows:
  • Embodiments in which the active substance is constituted by the product dissolved in an organic solvent.
  • the active substance is constituted by the product dissolved in an organic solvent.
  • the most common in the aerosol world the presence of water and the formation of a residue containing water are avoided as much as possible;
  • the active substance is constituted by a water / oil emulsion.
  • the external phase is constituted by an organic liquid not miscible with water (oils) and the dispersed (internal) phase is constituted by water or an aqueous solution;
  • Embodiments in which the active substance is constituted by an aqueous solution of surfactants or by an oil / water emulsion solution (which are mixed when the content is stirred);
  • Embodiments in which the active substance is constituted by a pulverulent substance (powder with particles of the smallest possible size);
  • Embodiments in which the active substance is constituted by an aqueous solution They are called three-phase aerosols and have a reduced spray effect.
  • the propellant is what causes the contents of the aerosol container to flow through the valve.
  • the aerosol can be used by vaporization by pulsation or total discharge and can be filled as a conventional aerosol with its liquid and gaseous phases or by introducing the active substance from a "bag" system that consists of housing all the active matter inside a bag and filling the space between the container and said bag with any type of compressed gas that acts as a propellant.
  • the aerosol container As for the aerosol container, it has a lot to do with its predecessors, the siphon and the fire extinguisher. It consists, therefore, of a pressure-resistant container and a valve that is connected by an ascending tube with the liquid which in turn is subjected to pressure by a gas. While a compressed gas (usually carbon dioxide, C0 2 ) is used in the siphon and fire extinguisher that is in the gas space above the liquid phase of the container, instead of the aerosol container of compressed propellant gas, a gas under liquid pressure, from which a series of advantages and, in particular, new possibilities in the application technique are derived, as will be described later.
  • a compressed gas usually carbon dioxide, C0 2
  • the present invention therefore relates to an aerosol formulation (suitable for being applied in a micronized form) characterized in that it comprises at least one biodegradable and non-residual active substance with biocidal and / or phytosanitary efficacy.
  • biocide is understood as any synthetic or natural chemical substance intended to destroy, counteract, neutralize, prevent the action or exercise control of any other type on any organism considered harmful to man.
  • the biocidal active substance will be a substance with fungicidal, bactericidal and / or virucidal properties.
  • any synthetic or natural chemical substance is intended to destroy, counteract, neutralize, prevent the action or exert control of any other type on any organism considered harmful to plants (including vegetables, fruits and / or vegetables).
  • the main advantage of the invention lies on the one hand in its safety, since it is based on a solution of an active substance that is propelled abroad by means of a propellant (or propellant) consisting of at least one gas or mixture of gases at a suitable pressure and, on the other, in which as a consequence of being able to be applied in a micronized way, it is capable of reaching areas that other types of applications (spraying, washing, etc.) cannot reach by not being accessible to same.
  • a propellant or propellant
  • it must have sufficient disinfectant properties (biocides and / or phytosanitary) and simultaneously it must combine biodegradability properties, absence of residual effect and low toxicity and danger. As sufficient disinfectant properties are established those that meet the order of at least 50% reduction of the initial contamination.
  • said substance may consist of a food additive with preservative characteristics (disinfectants), such as sorbic acid and its salts, calcium propionate, benzoic acid and its salts, as well as, in general, any of those included in the positive list of additives, potassium sorbate being especially preferred for its characteristics of absence of toxicity and residual effect, as well as for its biodegradability and good disinfection efficiency.
  • sorbic acid and its salts such as calcium propionate, benzoic acid and its salts
  • potassium sorbate being especially preferred for its characteristics of absence of toxicity and residual effect, as well as for its biodegradability and good disinfection efficiency.
  • the active substance may consist of a substance of natural origin, such as an acid of plant origin (glycolic acid, citric acid or acetic acid, among others) or a natural extract (such as cinnamic aldehyde, eugenol, thymol or carvacrol, among others).
  • a substance of natural origin such as an acid of plant origin (glycolic acid, citric acid or acetic acid, among others) or a natural extract (such as cinnamic aldehyde, eugenol, thymol or carvacrol, among others).
  • an acid of plant origin such as an acid of plant origin (glycolic acid, citric acid or acetic acid, among others) or a natural extract (such as cinnamic aldehyde, eugenol, thymol or carvacrol, among others).
  • glycolic acid also known as hydroxyacetic acid
  • Other substances such as alcohols (ethanol, propanol, glycol
  • ⁇ preferably potassium sorbate
  • natural extracts and / or acids of plant origin preferably glycolic or hydroxyacetic acid
  • other additives such as deodorizers
  • the active substance is dissolved in a suitable solvent, preferably in a weight percentage of less than 60%.
  • Said solvent may be selected from water, alcohol or other solvents (such as glycols, non-polar hydrocarbons, polar hydrocarbons, etc.) or an azeotrope of at least two solvents (such as water and alcohol, for example).
  • the solution may comprise other substances such as surfactants (preferably anionic or non-ionic surfactants) or other substances with wetting or antifoaming power such as fatty alcohols or other ethoxylated active substances.
  • surfactants preferably anionic or non-ionic surfactants
  • the active substance is comprised in the formulation in a weight percentage between 20 and 60% and more preferably between 10 and 30% by weight.
  • the propellant (or propellant) agent of the formulation it is possible to use at least one liquid gas, understanding as such that substance that under ambient temperature (25 ° C) and atmospheric pressure are gaseous and, when the pressure increases, they are compressed in the form of steam until it reaches the saturation limit, so that, further increasing compression, the gas finally condenses as a liquid. Liquid phase condensation is only possible at a temperature below the critical temperature of the gas.
  • liquid (or liquefied) gases are hydrocarbons such as isobutane, propane, pentane or butane, among others, or liquefied organic gases, such as dimethyl ether.
  • the hydrocarbons may consist of halogenated hydrocarbons of low global warming potential (GWP) (preferably below 100 and more preferably below 50) such as HFO 1234 ze.
  • GWP global warming potential
  • This type of gas can also be used as a particular embodiment of the invention, in which case the usual range of pressure inside the aerosol is from 2 to 18 kg / cm 2 .
  • safety propellants or propellants
  • propellants are, for example, halogenated hydrocarbons or fluorinated gases. They are understood as propellant safety agents because they are neither combustible nor toxic and because they do not cause irritation of the mucous membranes. In addition, they are odorless and, from a chemical point of view, they are extraordinarily stable.
  • the liquefied gas selected as a propellant must fulfill several functions in the aerosol container. Each liquefied gas has a very precise vapor pressure at a certain temperature. This physical law is compiled in vaporization tables and steam graphs. Vapor pressure varies with relative intensity with temperature. At the same temperature, the vapor pressure of the gases varies individually. This implies that an intermediate, desired value of vapor pressure can be established through mixtures of gases and liquids with liquefied gases. The vapor pressure is therefore dependent on the temperature and composition of the liquid phase and does not vary when the liquid is gradually consumed by its exit through the riser and the valve or pulsator of the aerosol container. This is because the necessary amount of steam is always formed from the liquid phase in order to always keep the pressure in the vaporization space constantly increasing, until the last drop of liquid is consumed.
  • the propellant can preferably be selected from a group consisting of a compressed gas, preferably at least one diatomic gas such as nitrogen or oxygen, among others; at least one hydrocarbon of any type such as pentane, butane or propane, among others, or at least one liquefied organic gas such as dimethyl ether, as well as any combination thereof.
  • a compressed gas preferably at least one diatomic gas such as nitrogen or oxygen, among others; at least one hydrocarbon of any type such as pentane, butane or propane, among others, or at least one liquefied organic gas such as dimethyl ether, as well as any combination thereof.
  • the hydrocarbon may consist of at least one halogenated hydrocarbon of low GWP such as HFO 1234 ze.
  • the propellant is comprised in the formulation in a weight percentage of between 40 and 80% and more preferably between 50 and 60% by weight.
  • the active substances being in any case substances with disinfectant properties, biodegradable and without risks of cross contamination, which may be in certain conditions and applications combined with usual disinfectants, in order to increase the synergistic effect of these products.
  • the percentages in bold are by weight with respect to the formulation and the percentages not highlighted are by weight with respect to the propellant or the active substance solution, respectively:
  • Compressed gas preferably a 0-50% diatomic gas
  • Hydrocarbons not including halogenated 0-70% low GWP hydrocarbons
  • Compressed gas (preferably a 0-50% diatomic gas)
  • Hydrocarbons (not including halogenated 0-70% low GWP hydrocarbons)
  • Compressed gas (preferably a 0-50% diatomic gas)
  • Hydrocarbons (not including halogenated 0-70% low GWP hydrocarbons)
  • Glycolic acid or other acids > 0-45%
  • Compressed gas (preferably a 0-50% diatomic gas)
  • Hydrocarbons (not including halogenated 0-70% low GWP hydrocarbons)
  • Compressed gas (preferably a 0-50% diatomic gas)
  • Hydrocarbons (not including halogenated 0-70% low GWP hydrocarbons)
  • Compressed gas (preferably a 0-50% diatomic gas)
  • Hydrocarbons (not including halogenated 0-70% low GWP hydrocarbons)
  • Potassium Sorbate or other fungistatic additive > 0-45% Glycolic acid or other 0-20% acids
  • Compressed gas (preferably a 0-50% diatomic gas)
  • Hydrocarbons (not including halogenated 0-70% low GWP hydrocarbons)
  • Compressed gas (preferably a 0-50% diatomic gas)
  • Hydrocarbons (not including halogenated 0-70% low GWP hydrocarbons)
  • Orthophenylphenol or other disinfectants > 0-45%
  • Compressed gas (preferably a 0% diatomic gas)
  • Hydrocarbons (not including 5% halogenated low GWP hydrocarbons)
  • Compressed gas (preferably a 0% diatomic gas)
  • Hydrocarbons (not including halogenated 0% low GWP hydrocarbons)
  • Compressed gas (preferably a 0% diatomic gas)
  • Hydrocarbons (not including 5% halogenated low GWP hydrocarbons)
  • the aerosol formulation is contained in a container consisting of a closure or seal system and a suitable nozzle that provides micronization properties in the use or use of the aerosol.
  • a closure or seal system When the seal is broken, the solution of the active substance is expelled through the nozzle and driven by the propellant.
  • the special design of the nozzle causes the solution of the active substance to be applied with a micronized drop size (the size of microns), producing a mist that allows the active substance to reach all areas of the area to be disinfected.
  • the most important elements of the aerosol container are the following:
  • the container itself which can be of various materials: tin, aluminum, reinforced glass, plastic coated glass, PET, etc., and in different forms, although the most used are: monobloc aluminum container , two-element container with flanged bottom and three-element container with assembled lid and flanged bottom.
  • tin and aluminum finishes can be presented with a varnish for internal protection that protects the container from possible aggression of the product it contains.
  • the choice of the type of package will obviously depend on the chemical composition of the active substance to be packaged.
  • valves The purpose of the valve is to regulate exactly the amount of content to be ejected from the container. It must also act in such a way that the particle size is uniform and the effect of homogeneous spraying.
  • the valve not only comprises the button that is pressed for discharge, but also its internal mechanism, which is composed of: valve support, seals, basic or push-button tube, head and cannula or riser tube.
  • valve support, seals, basic or push-button tube, head and cannula or riser tube The different types of valves that can be used will also depend on the product to be expelled through it. There are several types of valves in this way:
  • Dosing valves which are pressure valves but in which, when compressing its button, only a certain amount of the content is expelled, the jet being interrupted below.
  • standard 1 "valves, either male or female, and 1" full discharge or metering valves will be used.
  • the method of application of the aerosol formulation defined above, both in the environment and on surfaces, is also a further object of the invention.
  • the liquid phase due to the overpressure of the steam that originates when the button is pressed, reaches the atmosphere through the ascending tube and the valve of the aerosol container, instantaneously producing the evaporation of the liquid propellant agent (when there is no overpressure). In this way, it is not possible to recover the aggregation state of the expanded gas.
  • the liquid phase is constituted by a mixture of propellant and active substance
  • the liquid formed by the active substance is sprayed or atomized as a result of spontaneous evaporation of the propellant.
  • This last aspect coincides with the well-known process of the sodium water siphon, whereby the proportional part of the gas dissolved in the liquid is very small, so that the jet that comes out is practically compact.
  • the degree of spraying can be increased, such that the substance particles active fluctuating in the air and, consequently, forming an aerosol within the strict original scientific sense of the term.
  • the liquid in the aerosol container is not miscible with the active product or substance, although it may form a dispersed emulsion phase.
  • the button of the aerosol container is operated, the content thereof is foam-shaped. This is due to the fact that in the package it is distributed in the product in the form of very fine drops, each of which, upon evaporation, forms a bubble, the whole of which constitutes the foam.
  • the liquid solvent or solvent mixture
  • the propellant becomes directly the carrier of the filler spray substance, as is the case, for example, in the case of dust or in the inhalation of certain pharmaceutical products.
  • the propellant agent comprises compressed gases
  • said gases will not be in a position to fulfill the functions described above relating to liquefied gases.
  • the difference is based on the fact that the compressed gases do not dissolve, practically, in the liquids of the different fillers. Its function is therefore limited, fundamentally, to the maintenance of internal pressure, while liquids dissolved in small quantities cannot be expected more than a coarse or coarse spray.
  • Compressed propellant gases can be ordered in two groups, in terms of their solubility in liquid fillers:
  • a) Virtually insoluble gases such as air, nitrogen or noble gases; and b) Gases with limited solubility, such as diazoic monoxide (nitrogen protoxide, very gas, N 2 0) or carbon dioxide (C0 2 ).
  • the overpressure in the container can therefore vary during consumption from 6.5 atm to 1.5 atm, that is, falling below 1 ⁇ 4 of the original value.
  • a certain solubility of the gas in the liquid somewhat reduces this pressure drop.
  • the considerable decrease in pressure during use imposes very narrow limits on compressed gases. Any leakage in the gas phase and any improper handling, due to excessive inclination of the container so that the end of the submerged tube is located in the gas phase when the button is operated, lead to considerable gas losses. Especially in the latter case, almost all of the gas is frequently leaked, so that the product is unusable. The loss of gas cannot be replaced in this case by the liquid phase, since the solubility of the compressed gas is insufficient, even in the second group corresponding to gases of limited solubility.
  • Every aerosol container is an automatic device that allows the product to be extracted or applied in the most convenient way in order to achieve an optimal effect through an oppression with the finger on the button.
  • the amount of the product to be applied more easily and more rationally than when pouring liquids can be distributed with this button.
  • the dosing valve assumes the quantitative limiting function
  • the automatism of the aerosol container makes unnecessary, in many cases, other products or auxiliary means, such as the use of brushes, manual injectors, sprayers or brushes to generate foam. In this way, it makes it possible to obtain foam ready for immediate use, as well as to supply a fine powdered product.
  • auxiliary means such as the use of brushes, manual injectors, sprayers or brushes to generate foam.
  • foam ready for immediate use as well as to supply a fine powdered product.
  • the convenience of handling this type of automatic pushbuttons cannot be exceeded. They are practical, simple and clean;
  • the automatic shut-off valve does not leak or tip the contents. Liquid substances do not evaporate and the content does not dry out.
  • the tightness of the container prevents the entry of air and possible impurities by dust, moisture or germs. In this way, oxidizable products can be used since the oxygen in the air will practically not come into contact with them;
  • biodegradable active substances in the aerosol can be combined with classic active substances, such as orthophenylphenol, glutaraldehyde or quaternary ammoniums, at low concentrations, in order to exert a shock disinfection leaving the minimum level possible residual;
  • classic active substances such as orthophenylphenol, glutaraldehyde or quaternary ammoniums
  • the use of the aerosols of the invention may be complementary to the use also in aerosol of other non-biodegradable active substances, increasing their spectrum of activity.
  • Fig 4 Graph showing the reduction of the microbial load in the environment (Number of colonies in the total number of exposed plates) according to example 1.
  • the left column (138, 44) corresponds to the initial number of colonies and the right column (49, 17) to the number of colonies after treatment;
  • Fig 5 Graph showing the reduction of the microbial load on surfaces (Number of colonies in the total number of exposed plates) according to example 1.
  • the left column (396, 176) corresponds to the initial number of colonies and the column from the right (217, 160) to the number of colonies after treatment; Image of one of the two aerosols at the start of disinfection in a 400 m 3 chamber to which 2 aerosols of 1 liter are applied;
  • (228, 149) corresponds to the initial number of colonies and the right column (196, 100) to the number of colonies after treatment;
  • the left column (39, 15) corresponds to the initial number of colonies and the right column
  • the test was carried out in empty cold rooms that had citrus content in commercial refrigerators.
  • Two chambers of different capacities (400 m 3 and 800 m 3 ) were used and the degree of initial contamination due to both fungi and bacteria on the surface of the walls and in the environment was analyzed.
  • Six room plates and six contact plates were used.
  • the potassium sorbate aerosols were then applied, with the ventilation equipment running for 30 minutes for the fan to properly distribute the entire product, and with the air renewal grilles covered.
  • the product was allowed to act for 24 hours (the chambers remained closed all that time), after which environment and surface samples were taken again to determine the reduction of fungal and bacterial contamination, thus measuring the effectiveness of the treatment .
  • Six room plates and six contact plates were used.
  • FIG. 2 An image of the application of aerosols in the chambers is shown in Fig. 2.
  • Each aerosol used has a capacity of 1000 ml and contains 750 ml of a mixture of gases and product, of which 375 ml is a 25% potassium sorbate solution (93.8 g of potassium sorbate in each canister).
  • a single dose treatment, 1 spray 1 liter per 200 m 3 chamber was studied and applied in two sizes different camera:
  • a graph is shown with the results of the reduction of the microbial load in the environment and in Fig. 5 a graph is shown with the results of the reduction of the microbial load on surfaces.
  • Fig. 6 the image of one of the two aerosols at the start of disinfection is shown in a 400 m 3 chamber to which 2 aerosols of 1 liter are applied.
  • Fig. 8 the contamination is shown 24 hours after treatment in different areas of the 400 m 3 chamber (left, door and right) in the environmental disinfection test.
  • the initial contamination in different areas (left, door and right) of the 400 m 3 chamber in the surface disinfection test is shown in Fig. 9.
  • the contamination is shown 24 hours after treatment in different areas (left, door and right) of the 400 m 3 chamber in the surface disinfection test.
  • Fig. 1 1 The distribution of the four aerosols in an 800 m 3 chamber to which 4 aerosols of 1 liter are applied is shown in Fig. 1 1;
  • Fig. 13 the contamination is shown 24 hours after treatment in different areas of the 800 m 3 chamber (central zone, bottom zone and door zone) in the environmental disinfection test.
  • Fig. 14 the initial contamination in different zones (door zone, central zone and bottom zone) of the 800 m 3 chamber in the surface disinfection test is shown.
  • Fig. 15 the contamination is shown 24 hours after the treatment in different zones (door zone, central zone and bottom zone) of the 800 m 3 chamber in the surface disinfection test.
  • EXAMPLE 2 The test was carried out in refrigerated truck containers of a refrigerated transport company.
  • the potassium sorbate aerosols were then applied, with the cold running for 30 minutes for the fan to properly distribute the entire product, and allowed to act for 24 hours (the containers remained closed all that time), after which were taken again samples of environment and surfaces to determine the reduction of contamination by fungi and bacteria, thus measuring the effectiveness of the treatment.
  • FIG. 16 An image of the application of the aerosol in the container is shown in Fig. 16.
  • Each aerosol has a capacity of 500 ml_ and contains 400 ml_ of a mixture of gases and product, of which 200 ml is 25% potassium sorbate solution (50 g of potassium sorbate in each pot).
  • 200 ml is 25% potassium sorbate solution (50 g of potassium sorbate in each pot).
  • two treatment doses 1 or 2 bottles per container, were studied.
  • FIG. 18 A graph showing the results of the reduction of the microbial load in the application on surfaces, before and after the treatment is shown in Fig. 18.
  • Fig. 21 and in Fig. 22 images of the treatment with a 500 ml aerosol of 5% are shown (on the left the images of the initial contamination are shown and on the right, 24 h after the treatment). Specifically, Fig. 21 shows the images of the environmental disinfection treatment and Fig. 22 shows the images of the surface disinfection treatment.

Abstract

L'invention concerne une formulation à propriétés biocides et/ou phytosanitaires et utilisée sous forme d'aérosol caractérisée en ce qu'elle comprend: (a) entre 20 et 60% en poids d'une solution d'au moins une substance active biodégradable à propriétés biocides et/ou phytosanitaires; et (b) entre 40 et 80% en poids d'au moins un agent propulseur ou gaz propulseur. Elle concerne également l'utilisation de cette formulation pour désinfecter des environnements et/ou des surfaces, ainsi que pour lutter contre des maladies post-récolte de légumes, de fruits et/ou de plantes par application sous forme d'aérosol.
PCT/ES2015/070496 2014-08-27 2015-06-25 Formulation biocide et/ou phytosanitaire utilisée sous forme d'aérosol à base de substances actives biodégradables non résiduelles WO2016030555A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201580058616.7A CN107105644B (zh) 2014-08-27 2015-06-25 用于气溶胶用途、由活性生物可分解不残留物质制备的生物杀灭和/或植物清洁制剂
AU2015308369A AU2015308369B2 (en) 2014-08-27 2015-06-25 Biocide and/or phytosanitary formulation for aerosol use, made of active biodegradable non-residual substances
ZA2017/01820A ZA201701820B (en) 2014-08-27 2017-03-14 Biocide and/or phytosanitary formulation for aerosol use, made of active biodegradable non-residual substances

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Application Number Priority Date Filing Date Title
ESP201431259 2014-08-27
ES201431259A ES2561933B2 (es) 2014-08-27 2014-08-27 Formulación biocida y/o fitosanitaria de aplicación en forma de aerosol basada en sustanciasactivas biodegradables no residuales

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ES2787703B2 (es) * 2019-04-15 2022-12-22 Agrofresh Inc Aparato y procedimientos para medir, monitorizar y controlar concentraciones quimicas de ingredientes activos en soluciones de tratamiento de plantas y de cultivos de plantas

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US5128161A (en) * 1991-03-12 1992-07-07 Par-Way Group Method for preparing aerosol packaged glaze forming composition
ES2358658A1 (es) * 2009-08-05 2011-05-12 Decco Iberica Post Cosecha, S.A. Formulación a base de aditivos alimentarios fungiestáticos para el control de enfermedades de postrecolección y método para su aplicación.
WO2013090540A1 (fr) * 2011-12-14 2013-06-20 Crystal Enterprises Incorporated Composition biocide, dispositif et procédé de distribution d'une composition biocide
ES2457720A1 (es) * 2012-10-25 2014-04-28 Gases Research Innovation & Technology, S.L. Composición propelente licuada para aerosoles

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CN107105644A (zh) 2017-08-29
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CN107105644B (zh) 2020-12-01
AU2015308369B2 (en) 2018-11-08
AU2015308369A1 (en) 2017-03-23

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