WO2016006363A1 - Dispositif d'analyse automatique - Google Patents

Dispositif d'analyse automatique Download PDF

Info

Publication number
WO2016006363A1
WO2016006363A1 PCT/JP2015/065713 JP2015065713W WO2016006363A1 WO 2016006363 A1 WO2016006363 A1 WO 2016006363A1 JP 2015065713 W JP2015065713 W JP 2015065713W WO 2016006363 A1 WO2016006363 A1 WO 2016006363A1
Authority
WO
WIPO (PCT)
Prior art keywords
dispensing probe
reagent
automatic analyzer
reaction vessel
probe
Prior art date
Application number
PCT/JP2015/065713
Other languages
English (en)
Japanese (ja)
Inventor
励 小西
稔 佐野
牧野　彰久
Original Assignee
株式会社 日立ハイテクノロジーズ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社 日立ハイテクノロジーズ filed Critical 株式会社 日立ハイテクノロジーズ
Priority to JP2016532497A priority Critical patent/JP6307606B2/ja
Priority to CN201580033589.8A priority patent/CN106471376B/zh
Publication of WO2016006363A1 publication Critical patent/WO2016006363A1/fr

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Definitions

  • the present invention relates to a technology relating to an automatic analyzer that automatically analyzes components such as blood.
  • an analyzer that analyzes the amount of components contained in a sample, it measures the amount of transmitted light or scattered light of single or multiple wavelengths obtained by irradiating light from a light source onto a reaction mixture in which the sample and reagent are mixed.
  • An automatic analyzer that calculates the amount of a component from the relationship between the amount of light and the concentration is known.
  • There are roughly two types of analysis methods for reaction solutions colorimetric analysis using a color reaction between a substrate and an enzyme, and homogeneous immunoassay using an agglutination reaction by binding of an antigen and an antibody.
  • homogeneous immunoassay measurement methods such as immunoturbidimetry and latex agglutination are known.
  • an antibody-containing reagent is used to generate an immune complex with a measurement target (antigen) contained in a sample, and these are optically detected to quantify the amount of components.
  • a reagent containing latex particles sensitized (bound) with an antibody on the surface is used to agglutinate latex particles by antigen-antibody reaction with the antigen contained in the sample, and these are detected optically. Quantify the amount of ingredients.
  • a heterogeneous immunoassay apparatus that performs more sensitive immunoassay by a detection technique using chemiluminescence or electrochemiluminescence and a B / F separation technique is also known.
  • blood coagulation ability includes an exogenous one that coagulates blood leaking out of the blood vessel and an intrinsic one that coagulates blood inside the blood vessel.
  • the measurement items related to blood coagulation ability include prothrombin time (PT) of extrinsic blood coagulation reaction test, activated partial thromboplastin time (APTT) of intrinsic blood coagulation reaction test, and fibrinogen amount ( Fbg) and the like. In these items, it is necessary to sufficiently agitate the mixed solution of the sample and the reagent in order to stably progress the blood coagulation reaction.
  • PT prothrombin time
  • APTT activated partial thromboplastin time
  • Fbg fibrinogen amount
  • Patent Document 1 JP-A-7-239334. This publication describes a method of uniformly mixing a small amount of a sample solution with an accurate mixing ratio while stirring efficiently with a second solution. At that time, it is described that the tip of the sample liquid pipette tip is stopped in contact with or close to the inner side wall surface of the container and the liquid is discharged.
  • Patent Document 1 describes a method of efficiently stirring a small amount of sample liquid with a second liquid.
  • the agitation method of Patent Document 1 does not consider the lifting of the liquid due to the capillary phenomenon. For example, when discharging a liquid by bringing a dispensing probe into contact with or close to the inner side wall surface of the reaction vessel, a capillary phenomenon occurs in a gap formed between the dispensing probe and the inner side wall surface of the reaction vessel, and the liquid is discharged. In some cases, it travels along the outer wall surface of the dispensing probe.
  • the present invention provides a stepped region on the inner side wall surface of the reaction vessel, suppresses capillary action that occurs in the gap between the dispensing probe and the reaction vessel, and reduces the lifting of the reagent, thereby contaminating the dispensing probe.
  • An automatic analyzer capable of limiting the above is provided.
  • the reaction container which can restrict
  • the reaction container has a stepped portion protruding inward on the inner side wall surface, and the control unit is dispensed.
  • An automatic analyzer that lowers the dispensing probe so that the tip of the probe is below the stepped portion and discharges the reagent while the dispensing probe is in contact with the stepped portion.
  • the control unit reacts the tip of the dispensing probe after lowering the dispensing probe
  • the reaction container is a reaction container of an automatic analyzer that includes a stepped portion that protrudes from the inner side wall surface that contacts the side surface of the container and discharges the reagent.
  • the lifting of the liquid to the upper part of the dispensing probe due to the capillary phenomenon is suppressed, so that the dispensing probe can be easily cleaned and the possibility of carryover and contamination is reduced. can do.
  • the reaction container of the automatic analyzer of the present invention when the reagent is dispensed by bringing it into contact with the reaction container at the time of dispensing, the same effect as described above can be obtained.
  • FIG. 5 is a flowchart showing the operation of a dispensing probe.
  • FIG. 6 is an explanatory view showing the operation of the dispensing probe.
  • These are explanatory drawings which showed the relationship between the shape of the reaction container which concerns on Example 1, the contamination area
  • These are the longitudinal cross-sectional views which show the modification of the reaction container which concerns on Example 2.
  • FIG. These are the longitudinal cross-sectional view and top view which show the modification of the reaction container concerning Example 3.
  • FIG. 5 is a flowchart showing the operation of a dispensing probe.
  • FIG. 6 is an explanatory view showing the operation of the dispensing probe.
  • FIG. 1 is a schematic configuration diagram showing an outline of a configuration of an automatic analyzer 1 according to an embodiment of the present invention.
  • the automatic analyzer 1 includes a sample container 20 that stores a sample such as a standard sample or a test sample, and a sample disk 21 that holds the sample container 20.
  • a reagent container 30 that contains a reagent containing a component that reacts with a component of each test item included in the sample, and a reagent disk 31 that holds and cools the reagent container 30 are provided.
  • sample probe 22 that sucks the sample in the sample container 20 held on the sample disk 21 and dispenses it into the disposable reaction container 50.
  • a reagent dispensing probe 60 that sucks the reagent in the reagent container 30 held on the reagent disk 31 and dispenses it into the disposable reaction container 50 is provided.
  • the sample probe 22 performs a sample and reagent suction operation and a discharge operation in accordance with the operation of the sample syringe pump.
  • the reagent dispensing probe 60 performs a suction operation and a discharge operation in accordance with the operation of the reagent syringe pump.
  • the sample syringe pump and the reagent syringe pump can be finely operated and are controlled by the control unit 100 so that the dispensing accuracy can be strictly managed to a minute value.
  • a disposable reaction container 50 is installed in the detection unit 72 and the sample dispensing port 74, and a reaction container transfer mechanism 71 is provided for transporting the used disposable reaction container 50 for disposal.
  • the sample and the reagent are dispensed into the disposable reaction vessel 50 and mixed to start the reaction between the sample and the reagent.
  • a disposable reaction container 50 holding a mixed solution of a sample and a reagent is installed, a reaction between the sample and the reagent is detected, and the sample is inspected from the mixed solution.
  • the detection unit 72 includes a light source and a light receiving unit.
  • the light source uses, for example, an LED
  • the light receiving unit uses, for example, a photodiode.
  • the installed disposable reaction vessel 50 is irradiated with light from the light source from below, and this light is scattered by the precipitate produced by the reaction of the mixed solution. As the amount of precipitates increases, the amount of scattered light also increases. Therefore, the amount of precipitates is calculated by detecting the scattered light with a light receiving unit. For example, in a coagulation test item, when a specimen and a reagent react, time passes and fibrin precipitates. As the fibrin increases, the amount of light scattered increases. By monitoring this amount of light, the amount of fibrinogen (Fbg) can be inspected. In addition, by monitoring the amount of light in the same manner using a reagent corresponding to the test item, other coagulation items such as prothrombin time (PT) and activated partial thromboplastin time (APTT) can also be tested.
  • the detection unit 72 is kept at a constant temperature in order to promote the reaction between the sample and the reagent, and 37 ° C. is preferable.
  • a reagent dispensing probe 60 is provided that discharges a reagent into a disposable reaction container 50 installed in the detection unit 72 and dispenses the reagent.
  • a cleaning tank 73 for cleaning the sample probe 22 and the reagent dispensing probe 60 is provided.
  • the controller 100 controls the sample disk 21, the reagent disk 31, the sample dispensing probe 22, the reagent dispensing probe 60 up and down, the horizontal operation, the operation of the sample syringe and the reagent syringe, and the cleaning tank 73.
  • Control of all automatic elements constituting the automatic analyzer 1 such as discharge and stop operation of the washing water 75, control of the light source and light receiving unit of the detection unit 72, concentration calculation, and the like is performed.
  • this reaction vessel 50 to be used has a stepped portion 51 protruding inward on the inner side wall surface.
  • the protruding height horizontal width
  • the vertical width is about 0.8 mm.
  • the height of the reaction vessel is about 26 mm
  • the distance from the opening to the step is about 11 mm
  • the distance from the bottom to the step is about 15 mm.
  • the height of the step portion is designed so that the mixed solution does not touch even if the mixed solution of the sample and the reagent is accommodated.
  • the step portion 51 is arranged in an annular shape and arranged in all directions.
  • the sample held in the sample container 20 installed on the sample disk 21 is sucked by the sample probe 22.
  • the reaction container transfer mechanism 71 installs the disposable reaction container 50 in the sample dispensing port 74.
  • the sample probe 22 dispenses the sample into the disposable reaction vessel 50 installed in the sample dispensing port 74.
  • the reaction container transfer mechanism 71 transfers the disposable reaction container 50 from the sample dispensing port 74 to the detection unit 72 and installs it.
  • the temperature of the sample installed in the detection unit 72 is increased.
  • the reagent held in the reagent container 30 installed on the reagent disk 31 is aspirated by the reagent dispensing probe 60.
  • the reagent dispensing probe 60 is equipped with a heater, and is kept at a constant temperature of 37 ° C., for example.
  • the aspirated reagent is preheated in the reagent dispensing probe.
  • the coagulation reagent dispensing probe 60 moves horizontally as shown in FIG. 3 (a), and moves to the center and above the disposable reaction vessel 50.
  • the reagent dispensing probe 60 is lowered.
  • the control unit 100 lowers the probe so that the tip of the reagent dispensing probe 60 comes below the stepped portion 51.
  • the reagent dispensing probe 60 moves horizontally and stops at the position where the tip of the probe is brought into contact with the stepped portion 51 provided on the inner side wall surface of the disposable reaction vessel 50.
  • the reagent is discharged in a state where the reagent dispensing probe 60 is stopped, that is, in a state where the reagent dispensing probe 60 is in contact with the stepped portion 51.
  • the sample 62 and the reagent 61 are mixed at the moment when the reagent is discharged.
  • the probe includes water 63 for pushing out the reagent 61 and a gap 64 for preventing the reagent 64 from being diluted by the water 63 before the reagent 61 is discharged.
  • the liquid mixture is stirred by the discharge force of the reagent without separately stirring using an external stirring means.
  • the reagent dispensing probe 60 can move while moving the tip to the center of the disposable reaction vessel 50, that is, in an oblique direction. In this manner, the reagent dispensing probe 60 is raised after being moved close to the central axis of the disposable reaction vessel 50, or moved obliquely upward.
  • the reagent dispensing probe 60 is moved horizontally to the washing tank 73 and then washed with the washing water 75 as shown in FIG.
  • the step S107 can be omitted as the second modification.
  • the reagent dispensing probe 60 can be raised while maintaining the horizontal position where the tip is in contact with the stepped portion 51 on the inner side wall surface of the disposable reaction vessel 50.
  • the reagent dispensing probe 60 can be raised while in contact with the stepped portion 51.
  • the reagent dispensing probe 60 moves horizontally to the washing tank 73.
  • the reagent dispensing probe 60 is washed with the washing water 75 in the washing tank 73.
  • FIG. 4 is an explanatory diagram showing the relationship between the shape of the disposable reaction container 50 according to the first embodiment, the contaminated area of the reagent dispensing probe 60, and the washable range.
  • FIG. 4A shows an example when the reagent is discharged into the disposable reaction vessel 50 without the stepped portion 51. Even when there is no step 51, discharging the reagent from the side surface of the reaction container is very effective from the viewpoint of stirring efficiency of the sample 62 and the reagent.
  • a part of the reagent rises due to a capillary phenomenon in a slight gap generated between the reaction container side surface and the probe, and reaches the vicinity of the opening of the reaction container. That is, the contaminated area that needs to be cleaned later extends to the vicinity of the opening. For this reason, the cleaning range in the cleaning tank 73 needs to be at least the entire region of the probe that has entered the opening.
  • FIG. 4B shows a case where there is a step 51.
  • the probe and the stepped portion 51 are in contact with each other.
  • a part of the reagent rises due to capillary action as in the case of (a), but since the probe and the stepped portion 51 are in contact, the reagent cannot rise any further. That is, the contaminated area is from the probe tip to the contact point with the stepped portion 51.
  • the cleaning range in the cleaning tank 73 need only be a range having a predetermined amount of margin upward from the point of contact with the stepped portion 51.
  • the length of the probe inserted into the opening is about 15 mm
  • the length from the probe tip to the stepped portion 51 is about 4 mm
  • the margin is about 2 mm.
  • the cleaning tank 73 it is sufficient for the cleaning tank 73 to clean a range of about 6 mm from the probe tip. This is a significant improvement compared to the case where the area of about 15 mm has to be cleaned when there is no stepped portion 51.
  • the reagent When the reagent reaches the sample directly without passing through the side of the reaction vessel, it is because it is away from the interface between the sample and the side of the reaction vessel, which is the most efficient stirring, even when it reaches the sample through the side of the reaction vessel. This is because the collision between the reagent and the side surface of the reaction container becomes larger than that in the case where the probe tip is completely in contact, and the momentum of the reagent entering the sample is weakened. For this reason, it is desirable to discharge the reagent with the probe tip also in contact with the side surface of the reaction vessel. This will be described below.
  • FIG. 4 (b) is a diagram showing a state where the tip of the probe is also in contact with the side surface of the reaction vessel.
  • the reaction vessel will be described on the assumption that the vertical cross section is circular.
  • a be the radius of the vertical cross section including the point where the tip of the probe and the wall of the reaction vessel contact.
  • b the radius of the vertical cross section including the point where the probe and the stepped portion 51 come into contact.
  • c be the elastic range between the contact points of the probe tip and the side surface in the direction perpendicular to the axial direction of the probe. When in the range of 0 ⁇ b ⁇ a ⁇ c, the probe can be easily pressed against the reaction vessel, the contact point between the tip of the probe and the wall of the reaction vessel, and the contact point between the probe and the step portion 51. Can be brought into contact with each other.
  • the value c varies depending on the size of the outer diameter of the probe, the material, and the distance between the contact points.
  • the tip of the probe becomes the reaction vessel. It is considered that it is difficult to get caught on the side surface and bring the side surface of the probe into contact with the stepped portion 51. Therefore, regarding the protruding height of the step portion of the reaction vessel, the horizontal distance between the step portion 51 and the central axis of the reaction vessel and the horizontal distance between the point where the tip of the reaction vessel contacts and the central axis are The difference is desirably 0.2 mm or less.
  • the probe tip contacts the side surface of the container, and this is not an essential embodiment.
  • the structure of the reaction container that satisfies the following conditions is desirable regardless of the presence or absence of contact at the tip.
  • the distance between the dispensing probe and the inner wall of the reaction vessel in the adjacent region on the opening side of the stepped portion with the stepped portion 51 as a boundary is larger than the distance between the inner wall of the adjacent region on the bottom side of the stepped portion 51. .
  • the inner diameter in the adjacent region on the opening side of the stepped portion is larger than the inner diameter in the adjacent region on the bottom side.
  • contact area means to the range about 5 mm away from the level
  • Reagent rise can be suppressed.
  • the distance between the probe tip and the reaction container is small, so that the reagent easily flows along the side surface of the reaction container.
  • the stirring force is reduced as compared with the case where the probe tip is in contact with the side surface of the reaction container, a constant amount of stirring force due to reagent discharge can be maintained.
  • the reagent dispensing probe 60 Since the reagent dispensing probe 60 is brought into contact with the stepped portion 51 in this way and the reagent is discharged, the reagent lift due to the capillary phenomenon is suppressed, so that the contamination range of the outer wall of the reagent dispensing probe 60 can be limited. . According to this, at the time of cleaning the reagent dispensing probe 60 in the cleaning tank 73, only a limited range of the probe needs to be cleaned, and as a result, the cleaning time and the amount of cleaning water used can be reduced. Moreover, since not only the liquid adhering to the outer wall of the probe but also the liquid adhering to the inner side wall surface of the disposable reaction vessel 50 can be reduced, the waste of valuable reagents and specimens can be reduced. These enable efficient operation of the apparatus.
  • the liquid adhering to the outer wall of the probe has an effect of being removed by the stepped portion 51 of the disposable reaction vessel 50, so that waste of liquid can be further reduced.
  • Example 2 will be described with reference to FIG.
  • only one stepped portion 51 of the disposable reaction vessel 50 is provided.
  • two or more stepped portions 51 of the disposable reaction vessel 50 are provided.
  • the upper step portion 51 is a step portion 51 newly provided. Accordingly, the mixed liquid is not changed in contact with the stepped portion 51.
  • the probe discharges the reagent while the side surface of the probe is in contact with the two or more step portions 51.
  • the stepped portion 51 on the opening side can prevent the liquid from being lifted due to capillary action.
  • the reagent dispensing probe 60 by bringing the reagent dispensing probe 60 into contact with the step portion on the bottom side and the opening side, the inclination of the probe can be controlled more easily.
  • Example 3 will be described with reference to FIG.
  • the inner diameter dimension is the same on the opening side and the bottom side of the disposable reaction vessel 50 with the stepped portion 51 as a boundary (except for the vicinity of the bottom on the bottom side of the vessel).
  • the inner diameter on the opening side is made larger than the inner diameter on the bottom side of the disposable reaction vessel 50.
  • the step 51 is arranged above the probe tip as in the other embodiments.
  • the distance between the probe and the inner wall of the disposable reaction vessel 50 increases on the opening side with the stepped portion 51 as a boundary, so that the lift of the reagent due to the capillary phenomenon can be more effectively prevented.
  • the step of the stepped portion where the inner diameter of the stepped portion 51 spreads outward is 0.25 mm or more.
  • the distance between the side surface of the probe and the inner wall of the reaction vessel above the step is 0.3 mm or more. If a distance of 0.3 mm or more can be secured, it is possible to prevent the reagent from being lifted due to capillary action.
  • the reagent can be prevented from lifting if it is somewhat upward, but it becomes gradually wider by providing a step 51 as shown in FIG. Compared to the case, more of the reagent to be raised accumulates on the upper surface of the step portion 51, so that the contaminated area can be effectively reduced.
  • the bent portion 65 is provided in the reagent dispensing probe 60, thereby increasing the distance between the reagent dispensing probe 60 and the inner wall of the disposable reaction container 50.
  • the step portion 51 is not necessarily required.
  • the probe includes a first axis extending from the base of the probe, a bent portion 65, and a second axis including the probe tip below the bent portion 65.
  • the rise of a part of the reagent discharged from the probe by the bent portion can be suppressed.
  • the reagent can be prevented from being lifted by capillary action.
  • the side surface of the probe is not necessarily in contact with the stepped portion 51, and the probe tip only needs to be in contact with or close to it. It is sufficient that the distance between the adjacent eyes is within 1 mm.
  • the stepped portion 51 and the bent portion 65 can suppress an increase in the reagent discharged from the probe.
  • the cleaning range can be made narrower than when these devices are not devised.
  • cleaning range can be narrowed by providing the area
  • this invention is not limited to the above-mentioned Example, Various modifications are included.
  • the above-described embodiments have been described in detail for easy understanding of the present invention, and are not necessarily limited to those having all the configurations described.
  • the light from the light source is irradiated from below the reaction vessel, but may be irradiated from the side surface.
  • a part of the configuration of one embodiment can be replaced with the configuration of another embodiment, and the configuration of another embodiment can be added to the configuration of one embodiment.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

En résultat d'un phénomène capillaire qui se produit dans un espace entre une sonde de distribution et un récipient de réaction, un réactif s'élève pendant une évacuation de réactif, et une grande zone de nettoyage est requise pour la sonde de distribution. A cet effet, l'invention porte sur un dispositif d'analyse automatique, dans lequel dispositif : le récipient de réaction (50) a une section étagée (51) dans le côté paroi interne de ce dernier qui fait saillie vers l'intérieur; une unité de commande abaisse la sonde de distribution (60) de telle sorte que la pointe de la sonde de distribution arrive en dessous de la section étagée; et le réactif est évacué, dans un état dans lequel la sonde de distribution est amenée à être en contact avec la section étagée.
PCT/JP2015/065713 2014-07-09 2015-06-01 Dispositif d'analyse automatique WO2016006363A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2016532497A JP6307606B2 (ja) 2014-07-09 2015-06-01 自動分析装置
CN201580033589.8A CN106471376B (zh) 2014-07-09 2015-06-01 自动分析装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014141000 2014-07-09
JP2014-141000 2014-07-09

Publications (1)

Publication Number Publication Date
WO2016006363A1 true WO2016006363A1 (fr) 2016-01-14

Family

ID=55064005

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2015/065713 WO2016006363A1 (fr) 2014-07-09 2015-06-01 Dispositif d'analyse automatique

Country Status (3)

Country Link
JP (2) JP6307606B2 (fr)
CN (1) CN106471376B (fr)
WO (1) WO2016006363A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3749457B1 (fr) * 2018-02-05 2023-06-07 L'etat Français Représenté Par Le Ministère De L'intérieur Dispositif de stockage à température ambiante de matériels biologiques

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106471376B (zh) * 2014-07-09 2018-01-12 株式会社日立高新技术 自动分析装置

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5943363A (ja) * 1982-07-30 1984-03-10 チバ　コーニング　ダイアグノスティクス　コーポレーション 分光光度分析器
JPS646760A (en) * 1987-06-27 1989-01-11 Yasunobu Tsukioka Washing apparatus for reaction vessel in inspecting apparatus of blood and the like
JPH0381558U (fr) * 1989-12-11 1991-08-20
JPH07174763A (ja) * 1993-09-17 1995-07-14 F Hoffmann La Roche Ag 分析装置と粒子の懸濁方法
JPH07239334A (ja) * 1994-02-25 1995-09-12 Fuji Photo Film Co Ltd 液体の混合方法
JPH08327507A (ja) * 1995-05-30 1996-12-13 Sanyo Electric Co Ltd 分注方法
JP2007205773A (ja) * 2006-01-31 2007-08-16 Juki Corp 分注装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58137758A (ja) * 1982-02-10 1983-08-16 Omron Tateisi Electronics Co 血液撹拌装置
JP2010117222A (ja) * 2008-11-12 2010-05-27 Beckman Coulter Inc 試料容器、分注装置、分注方法及び分析装置
JP5300447B2 (ja) * 2008-12-04 2013-09-25 ベックマン コールター， インコーポレイテッド 自動分析装置および自動分析装置における検体分注方法
JP5287609B2 (ja) * 2009-08-26 2013-09-11 株式会社島津製作所 反応容器
CN106471376B (zh) * 2014-07-09 2018-01-12 株式会社日立高新技术 自动分析装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5943363A (ja) * 1982-07-30 1984-03-10 チバ　コーニング　ダイアグノスティクス　コーポレーション 分光光度分析器
JPS646760A (en) * 1987-06-27 1989-01-11 Yasunobu Tsukioka Washing apparatus for reaction vessel in inspecting apparatus of blood and the like
JPH0381558U (fr) * 1989-12-11 1991-08-20
JPH07174763A (ja) * 1993-09-17 1995-07-14 F Hoffmann La Roche Ag 分析装置と粒子の懸濁方法
JPH07239334A (ja) * 1994-02-25 1995-09-12 Fuji Photo Film Co Ltd 液体の混合方法
JPH08327507A (ja) * 1995-05-30 1996-12-13 Sanyo Electric Co Ltd 分注方法
JP2007205773A (ja) * 2006-01-31 2007-08-16 Juki Corp 分注装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3749457B1 (fr) * 2018-02-05 2023-06-07 L'etat Français Représenté Par Le Ministère De L'intérieur Dispositif de stockage à température ambiante de matériels biologiques

Also Published As

Publication number Publication date
CN106471376A (zh) 2017-03-01
JP2018091867A (ja) 2018-06-14
JPWO2016006363A1 (ja) 2017-04-27
JP6539367B2 (ja) 2019-07-03
CN106471376B (zh) 2018-01-12
JP6307606B2 (ja) 2018-04-04

Similar Documents

Publication Publication Date Title
JP4938082B2 (ja) 洗浄装置、吸引ノズルの詰り検知方法及び自動分析装置
JP6255339B2 (ja) 自動分析装置
JP6462844B2 (ja) 自動分析装置
US11754580B2 (en) Sample measurement method and sample measurement device
JP5878377B2 (ja) 分析装置
JP4938083B2 (ja) 洗浄装置、洗浄ノズルの詰り検知方法及び自動分析装置
JP6742065B2 (ja) 自動分析装置および洗浄方法
US9513305B2 (en) Multiple cleaning stations for a dispensing probe
US10527638B2 (en) Automated analyzer and nozzle-cleaning method
JP6567873B2 (ja) 自動分析装置
JP6539367B2 (ja) 自動分析装置の反応容器
JP2010210596A (ja) 自動分析装置およびプローブ洗浄方法
JP5583337B2 (ja) 自動分析装置及びその分注方法
JP5748782B2 (ja) 自動分析装置
JP4422658B2 (ja) 液体分注装置
CN110352355B (zh) 自动分析装置和分析方法
JP2022179656A (ja) 検体測定装置および検体測定方法
JP6509218B2 (ja) 自動分析装置
JP2014238346A (ja) 自動分析装置
JP6004398B2 (ja) 自動分析装置
JP4966875B2 (ja) 自動分析装置
JP2015137975A (ja) 自動分析装置および試薬分注方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15818200

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2016532497

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15818200

Country of ref document: EP

Kind code of ref document: A1