WO2016002560A1 - Dispositif de mesure - Google Patents

Dispositif de mesure Download PDF

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Publication number
WO2016002560A1
WO2016002560A1 PCT/JP2015/067867 JP2015067867W WO2016002560A1 WO 2016002560 A1 WO2016002560 A1 WO 2016002560A1 JP 2015067867 W JP2015067867 W JP 2015067867W WO 2016002560 A1 WO2016002560 A1 WO 2016002560A1
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WO
WIPO (PCT)
Prior art keywords
light
detection unit
wavelength
housing
opening
Prior art date
Application number
PCT/JP2015/067867
Other languages
English (en)
Japanese (ja)
Inventor
勉 篠崎
右一 佐藤
悠平 福島
西村　望
敏晶 深井
Original Assignee
日本電気株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日本電気株式会社 filed Critical 日本電気株式会社
Priority to JP2016531275A priority Critical patent/JP6705593B2/ja
Publication of WO2016002560A1 publication Critical patent/WO2016002560A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid

Definitions

  • the present invention relates to a measuring apparatus that detects and measures a specific component using light.
  • Patent Document 1 discloses an apparatus for measuring a blood sugar level in blood.
  • a light source, a light receiving element, and a waveguide are provided on the upper surface of the base portion. And a part of waveguide is exposed to the lower surface of a base part, and the light which the light source produced
  • reflected light is incident on this part. The incident reflected light is guided to the light receiving element.
  • Patent Document 2 describes that light is applied to the skin in an oblique direction, and a plurality of light receiving portions are arranged obliquely and spaced apart.
  • the technique described in Patent Document 2 is intended to measure glucose contained in skin and blood.
  • the intensity and wavelength of the light may vary depending on the environment such as humidity and the temperature of the light source. If the light emitted from the light source fluctuates, the measurement accuracy of the target component may be reduced when a specific component is detected using the light. Therefore, there is a demand for a technique that can suppress the influence of the light source fluctuation caused by such an environment and improve the measurement accuracy.
  • An object of the present invention is to provide a technique capable of improving measurement accuracy by suppressing the influence of fluctuations in light of a light source caused by the environment when detecting and measuring a specific component using light.
  • a housing An opening provided in a part of the housing; A light emitting means disposed inside the housing and emitting light including a first wavelength toward the opening; A first light detecting means arranged in the housing toward the opening and detecting the light of the first wavelength; A reflecting member disposed not at the optical axis of the light emitting means but at a position overlapping the light emission region of the light emitting means; A second light detecting means disposed in the casing toward a position overlapping with the light emission region, and detecting light of the first wavelength; A measuring device is provided.
  • the present invention when detecting and measuring a specific component using light, it is possible to suppress the influence due to light fluctuation of the light source caused by the environment and improve the measurement accuracy.
  • the constituent elements of the measuring apparatus 10 indicate functional unit blocks, not hardware unit configurations.
  • the correction unit 144, the control unit 150, and the calculation unit 160 include a CPU, a memory, a program that implements the components shown in the figure loaded in the memory, a storage medium such as a hard disk that stores the program, and a network. It is realized by any combination of hardware and software, centering on the connection interface. There are various modifications of the implementation method and apparatus.
  • FIG. 1 is a block diagram conceptually showing the structure of the measuring apparatus 10 in the first embodiment.
  • the measuring apparatus 10 of this embodiment includes a housing 100, a light emitting unit 120, a reflecting member 130, a first light detection unit 140, and a second light detection unit 142.
  • the housing 100 is provided with an opening 102.
  • the light emitting unit 120, the reflecting member 130, the first light detection unit 140, and the second light detection unit 142 are disposed inside the housing 100.
  • the light emitting unit 120 emits light including the first wavelength toward the opening 102.
  • the first light detection unit 140 is disposed toward the opening 102 and detects light having the first wavelength.
  • the optical axis of the first light detection unit 140 passes through the opening 102 and detects the intensity of the first wavelength light.
  • the optical axis of the first light detection unit 140 is defined as a line that passes through the center of the light receiving surface of the first light detection unit 140 and is perpendicular to the light receiving surface of the first light detection unit 140, for example.
  • the optical axis L of the light emitting unit 120 and the optical axis of the first light detection unit 140 intersect at a position ⁇ outside the housing 100.
  • the reflecting member 130 is disposed so as to include a part of the light emission region A of the light emitting unit 120 at a position that does not overlap the optical axis L of the light emitting unit 120, and a part of the light emitted from the light emitting unit 120.
  • the second light detection unit 142 is disposed toward a position where the reflection member 130 and the light emission region A overlap each other, and detects the light having the first wavelength, similarly to the first light detection unit 140.
  • the optical axis of the second light detection unit 142 passes through a position where the reflection member 130 and the emission region A of the light emitting unit 120 overlap, and detects the intensity of the first wavelength light.
  • the optical axis of the second light detection unit 142 is defined as a line that passes through the center of the light receiving surface of the second light detection unit 142 and is perpendicular to the light receiving surface of the second light detection unit 142, for example.
  • the optical axis L of the light emitting unit 120 and the optical axis of the second light detection unit 142 intersect at a position ⁇ inside the housing 100.
  • a correction unit 144 is further provided.
  • the correction unit 144 may be provided in the measurement apparatus 10 or may be provided in another apparatus that is connected to the measurement apparatus 10 so as to be communicable. Details will be described below.
  • the measuring device 10 is a device that measures a sugar content (for example, glucose) contained in an interstitial fluid of living skin, for example, dermal tissue.
  • the first wavelength is in the near infrared region (for example, 1200 nm or more and 3000 nm or less).
  • the measuring device 10 is used in a state in which the object 20 (for example, biological skin) is brought close to the opening 102.
  • the housing 100 is formed using, for example, resin or metal.
  • An opening 102 is provided on one surface of the housing 100.
  • the housing 100 may be composed of a plurality of components or a plurality of members.
  • the opening 102 provided in the housing 100 may be closed by, for example, a translucent member (not shown) that transmits light of the first wavelength.
  • the translucent member is a plate-like member made of, for example, glass or resin.
  • the translucent member may be a flat plate or may be slightly curved as long as it is designed to intersect at a position ⁇ outside the housing 100.
  • the light emitting unit 120 includes a light emitting element such as an LED (Light Emitting Diode) or a laser diode as a light source.
  • This light source preferably emits light of the first wavelength stronger than light of other wavelengths.
  • an optical filter that transmits only a specific wavelength may be arranged on the path of light emitted from the light emitting element of the light emitting unit 120.
  • the optical axis of the light emitting unit 120 is disposed toward the opening 102. For this reason, when the skin of the living body is brought close to the opening 102 provided in the housing 100, the optical axis of the light emitting unit 120 is inclined with respect to the surface of the skin.
  • the first light detection unit 140 includes a photoelectric conversion element such as a photodiode. This photoelectric conversion element preferably has higher sensitivity to light of the first wavelength than sensitivity of light of other wavelengths. Alternatively, although not shown, an optical filter that transmits only a specific wavelength may be disposed immediately before the photoelectric conversion element in order to increase sensitivity to a specific wavelength.
  • the light receiving surface of the first light detection unit 140 is disposed obliquely with respect to the outer surface of the housing 100 in which the opening 102 is provided. As illustrated in FIG. 1, the optical axis of the first light detection unit 140 intersects the optical axis L of the light emitting unit 120 at a position ⁇ outside the housing 100.
  • the distance between the intersection ⁇ of the two optical axes and the outer surface of the housing 100 provided with the opening 102 is 2 mm or less, preferably 1.5 mm or less.
  • the interval is preferably 0.5 mm or more.
  • the angle theta 1 which the two optical axes forms is, for example, 60 ° 120 ° or more or less. Note that the angle formed by the optical axis of the light emitting unit 120 with respect to the surface of the housing 100 on which the opening 102 is provided, and the first light detection unit 140 with respect to the surface of the housing 100 on which the opening 102 is provided.
  • the angles formed by the optical axes are preferably equal to each other.
  • the second light detection unit 142 also includes a photoelectric conversion element such as a photodiode. Similarly to the first light detection unit 140, the photoelectric conversion element of the second light detection unit 142 preferably has higher sensitivity to light of the first wavelength than that of light of other wavelengths. Alternatively, although not shown, an optical filter that transmits only a specific wavelength may be disposed immediately before the photoelectric conversion element in order to increase sensitivity to a specific wavelength.
  • the light receiving surface of the second light detection unit 142 faces the reflecting member 130 and is disposed obliquely with respect to the outer surface of the housing 100 in which the opening 102 is provided. As illustrated in FIG.
  • the optical axis of the second light detection unit 142 intersects with the optical axis L of the light emitting unit 120 at a position ⁇ inside the housing 100.
  • the angle theta 2 which the two optical axes forms is, for example, 60 ° 120 ° or more or less.
  • the angles formed by the optical axes are preferably equal to each other.
  • the reflecting member 130 has a property of reflecting light, and reflects the light emitted from the light emitting unit 120.
  • the reflecting member 130 is disposed at a position that does not overlap the optical axis L of the light emitting unit 120 but overlaps the light emission region A of the light emitting unit 120.
  • the position where the reflecting member 130 is disposed is not limited to the example of FIG.
  • FIG. 2 is a diagram when the surface on which the reflecting member 130 is provided is viewed from above.
  • a circle indicated by a dotted line indicates the light emission region A of the light emitting unit 120 on the surface where the reflecting member 130 is disposed.
  • the center of the circle indicated by the dotted line indicates the optical axis L of the light emitting unit 120.
  • the reflecting member 130 does not overlap the optical axis L of the light emitting unit 120, but converts the light emitted from the light emitting unit 120 in a part A ′ of the radiation region A (shaded portion in FIG. 2). They are arranged so as to overlap.
  • the reflection member 130 reflects the light passing through the part A ′ toward the second light detection unit 142.
  • FIG. 2 shows a case where the radiation area A is circular, but this is only an example, and the shape of the radiation area A is not limited to a circle.
  • the radiation region A may have a shape other than a circle (for example, a polygonal shape or a shape obtained by combining various shapes).
  • the reflection member 130 is disposed so as to block light in the range of 5 to 10%, for example, of the light passing through the surface on which the reflection member 130 is disposed from the light emitting unit 120.
  • the light reflected by the reflecting member 130 can be adjusted by the position and shape of the reflecting member 130.
  • the area of part A ′ is adjusted depending on the position and shape of the reflecting member 130, and as a result, the ratio of the light reflected by the reflecting member 130 to the light emitted from the light emitting unit 120 can be adjusted.
  • the reflecting member 130 is For example, 5 to 10% of the radiation range is arranged.
  • the reflecting member 130 is preferably disposed so that the light amount detected by the first light detection unit 140 and the light amount detected by the second light detection unit 142 are substantially equal.
  • the reflecting member 130 since the light detected by the first light detection unit 140 is greatly attenuated (about 90%) when it hits the object 20, the reflecting member 130 is about 5% of the light emitted from the light emitting unit 120. It is only necessary to be provided at a position where the light is reflected.
  • the shape of the reflecting member 130 is not limited to the example of FIG.
  • the reflecting member 130 can take various shapes such as an arc shape, a polygonal shape, or a combination thereof. Further, the reflecting member 130 may be divided into a plurality of pieces.
  • the correction unit 144 receives the light intensity detected by the first light detection unit 140 and the light intensity detected by the second light detection unit 142, respectively. Then, the correction unit 144 corrects the light intensity detected by the first light detection unit 140 using the light intensity detected by the second light detection unit 142. Specifically, the correction unit 144 divides the light intensity detected by the first light detection unit 140 by the light intensity detected by the second light detection unit 142. Thereby, the light intensity detected by the first light detection unit 140 is corrected based on the light intensity detected by the second light detection unit 142.
  • the amount or concentration of the measurement target included in the object 20 is calculated based on, for example, the following formula 1.
  • ⁇ is the amount or concentration of the measurement target contained in the object 20
  • I 1 is the intensity of light detected by the first light detection unit 140
  • I 2 is detected by the second light detection unit 142.
  • the light intensity, ⁇ represents a function for calculating the amount or concentration of the measurement object from the light intensity.
  • the light intensity I 1 detected by the first light detector 140 is corrected by the light intensity I 2 detected by the second light detector 142.
  • the function ⁇ for calculating the amount or concentration from the light intensity is measured using, for example, light of a specific wavelength whose intensity is known in advance and an object whose amount or concentration of the measurement object is known in advance. It is defined by. It is also possible to obtain a plurality of functions for different measurement objects and set them in the measurement apparatus 10 so that the measurement object of the measurement apparatus 10 is switched by an input unit (not shown).
  • the target object 20 such as a living skin is close to the opening 102.
  • the light emitting unit 120 emits light.
  • the light emitted from the light emitting unit 120 enters at least the dermis tissue of the skin and is scattered by the cell wall or the like.
  • the 1st light detection part 140 detects a part of this scattered light.
  • a part of this light is caused by a specific component in the skin, for example, sugar such as glucose contained in the interstitial fluid. Absorbed. Accordingly, the concentration of a specific component in the skin can be calculated based on the intensity measured from the light detected by the first light detection unit 140.
  • the second light detection unit 142 detects the light reflected by the reflecting member 130 and measures the intensity thereof. Since the light reflected by the reflecting member 130 does not pass through the measurement target, the intensity of the light detected by the second light detection unit 142 is proportional to the intensity of the light actually emitted from the light emitting unit 120. For this reason, the light intensity detected by the first light detection unit 140 can be corrected using the light intensity detected by the second light detection unit 142. In other words, the intensity of the light detected by the first light detection unit 140 is corrected to a state in which the fluctuation of the light of the light source due to the environment such as temperature is canceled. Therefore, according to this embodiment, the effect of improving the measurement accuracy of the measurement apparatus 10 can be expected.
  • the optical axis of the second light detection unit 142 of the present embodiment intersects with the optical axis of the light emitting unit 120 inside the housing 100 as illustrated in FIG. For this reason, light from the outside of the housing 100 is difficult to enter the second light detection unit 142. Further, by further devising the position of the intersection of the optical axis of the second light detection unit 142 and the optical axis of the light emitting unit 120 inside the housing 100, the light from the outside of the housing 100 is detected by the second light. It is desirable that the structure does not enter the portion 142.
  • the second light detection unit 142 of the present embodiment can accurately detect the pure light emitted from the light emitting unit 120, and as a result, the environment The precision which suppresses the influence by the fluctuation
  • the reflecting member 130 is preferably configured to irregularly reflect incident light by, for example, the material of the reflecting member 130 or a surface coating process. As a result, part of the light emitted from the light emitting unit 120 is irregularly reflected by the reflecting member 130. Even if the position of the reflecting member 130 is displaced due to, for example, manufacturing error of each measuring device 10 or distortion of the housing 100 due to external pressure, temperature, or the like due to irregular reflection of light, the second Variations in the intensity of light incident on the light detection unit 142 can be suppressed. As a result, it is possible to reduce the influence due to the positional deviation of the reflecting member 130 and to stably obtain the effect of improving the measurement accuracy by the second light detection unit 142.
  • FIG. 3 is a block diagram conceptually showing the structure of the measuring apparatus in the second embodiment.
  • the measurement apparatus 10 of the present embodiment has the same configuration as the measurement apparatus 10 of the first embodiment except for the following points.
  • the light emitting unit 120 includes a light source 122 and a lens 124.
  • the light source 122 has the light emitting element shown in the first embodiment.
  • the lens 124 condenses the light from the light source 122.
  • the condensing point of the light from the light source 122 by the lens 124 is located outside the opening 102. This condensing point preferably overlaps the optical axis of the first light detection unit 140, in other words, overlaps the position ⁇ where the two optical axes intersect.
  • the measurement apparatus 10 includes a correction unit 144, a control unit 150, a calculation unit 160, a display unit 170, and an input unit 180.
  • the input unit 180 is operated by the user of the measuring apparatus 10.
  • the input unit 180 is, for example, a push type or contact type switch, and is located on the outer surface of the housing 100.
  • the control unit 150 causes the light emitting unit 120 to emit light when input is made to the input unit 180.
  • the calculation unit 160 uses the intensity of light detected by the first light detection unit 140 after being corrected by the correction unit 144, and is included in the amount or concentration of a specific component in the measurement target, for example, interstitial fluid of the skin
  • the amount or concentration of sugar (e.g., glucose) to be obtained is calculated.
  • the calculation unit 160 can calculate the amount or concentration of a sugar (eg, glucose) contained in the interstitial fluid of the skin using, for example, the above formula 1.
  • the calculation unit 160 causes the display unit 170 to display the calculated result. Since the display unit 170 is located on the outer surface of the housing 100, the user of the measurement apparatus 10 can recognize the measurement result obtained by the measurement apparatus 10 by viewing the display unit 170.
  • FIG. 4 is a block diagram conceptually showing the structure of the measuring apparatus in the third embodiment.
  • the measurement apparatus 10 of the present embodiment has the same configuration as the measurement apparatus 10 of the first and second embodiments except for the following points.
  • FIG. 4 illustrates a configuration based on the second embodiment.
  • the measuring apparatus 10 further includes a light transmissive member 110 located in the opening 102.
  • the translucent member 110 transmits light including the first wavelength.
  • the translucent member 110 is not deformed when pressed against the measurement site.
  • the translucent member 110 also has a function of extending the wrinkles at the measurement site.
  • the reflective member 130 of this embodiment is arrange
  • the direction of the second light detection unit 142 is not limited to the direction illustrated in FIG.
  • the direction of the second light detection unit 142 may be directed to a position where the reflection member 130 and the light emission region A of the light emitting unit 120 overlap in a range where the reflected light from the reflection member 130 can be captured.
  • the optical path to the second light detection unit 142 has a structure of about several millimeters so that light other than the light from the reflection member 130 outside the housing 100 does not easily enter the second light detection unit 142. Good. More preferably, it is better to prevent light other than the light from the reflection member 130 outside the housing 100 from entering the second light detection unit 142, and further reduce the optical path to the second light detection unit 142. Better. For example, it is sufficient that the amount of light is sufficiently obtained.
  • the optical path diameter is 3 mm or less, more preferably the size of the photoelectric conversion element (0.3 to 1 mm). Can be about.
  • a guide serving as a guide path is received on the light receiving surface side of the second light detection unit 142. It may be provided extending from the surface in the direction of the reflecting member.
  • the reflecting member 130 is configured to diffusely reflect incident light depending on surface processing or material.
  • the reflective member 130 is drawn so as to have a certain thickness from the viewpoint of easy viewing of the drawing, but in practice, the reflective member 130 has a thickness that does not impair the function of the reflective member 130. Can do. Therefore, even if the reflecting member 130 is disposed on the outer surface of the translucent member 110, the measurement is not disturbed, and the user using the measuring apparatus 10 is less likely to feel bothered during the measurement.
  • part of the light emitted from the light emitting unit 120 passes through the translucent member 110 and is reflected by the reflecting member 130 located on the outer surface of the translucent member 110, so that the second light It is detected by the detection unit 142.
  • the 2nd light detection part 142 is the temperature at the time of a measurement, the change of the refractive index in the boundary surface of the translucent member 110, or various characteristics inside the translucent member 110. Light affected by changes can be detected.
  • the light attenuated by the object 20 can be detected with higher accuracy. can do.
  • an effect of improving the accuracy of measuring the measurement object can be expected.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Mathematical Physics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un dispositif de mesure (10) qui comprend : un boîtier (100) ; une ouverture (102) qui est formée dans une première partie du boîtier (100) ; une unité électroluminescente (120) qui est disposée à l'intérieur du boîtier (100) et qui rayonne, vers l'ouverture (102), une lumière qui a une première longueur d'onde ; une première unité de détection de lumière (140) qui est située à l'intérieur du boîtier (100) de façon à être dirigée vers l'ouverture (102), et qui détecte la lumière de la première longueur d'onde ; un élément réfléchissant (130) qui est disposé dans un emplacement qui ne chevauche pas un axe optique (L) de l'unité électroluminescente (120), mais qui chevauche une zone de rayonnement (A) de la lumière provenant de l'unité électroluminescente (120) ; et une seconde unité de détection de lumière (142) qui est située à l'intérieur du boîtier (100) de façon à être dirigée vers un emplacement qui chevauche la zone de rayonnement de la lumière, et qui détecte la lumière de la première longueur d'onde.
PCT/JP2015/067867 2014-07-03 2015-06-22 Dispositif de mesure WO2016002560A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2016531275A JP6705593B2 (ja) 2014-07-03 2015-06-22 測定装置

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Application Number Priority Date Filing Date Title
JP2014138025 2014-07-03
JP2014-138025 2014-07-03

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Publication Number Publication Date
WO2016002560A1 true WO2016002560A1 (fr) 2016-01-07

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01253634A (ja) * 1988-04-01 1989-10-09 Fuji Photo Film Co Ltd 反射濃度測定装置
JPH0943144A (ja) * 1995-07-27 1997-02-14 Canon Inc 濃度センサー
JP2008086705A (ja) * 2006-10-05 2008-04-17 Sanyo Electric Co Ltd 測定補助材およびそれを用いた光学測定方法
JP2010227558A (ja) * 2009-03-05 2010-10-14 Yokogawa Electric Corp 成分測定装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6826424B1 (en) * 2000-12-19 2004-11-30 Haishan Zeng Methods and apparatus for fluorescence and reflectance imaging and spectroscopy and for contemporaneous measurements of electromagnetic radiation with multiple measuring devices
JP2002261384A (ja) * 2001-02-28 2002-09-13 Ricoh Co Ltd 光通信システム
JP2005304832A (ja) * 2004-04-22 2005-11-04 Olympus Corp 成分濃度測定装置およびグルコース濃度測定装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01253634A (ja) * 1988-04-01 1989-10-09 Fuji Photo Film Co Ltd 反射濃度測定装置
JPH0943144A (ja) * 1995-07-27 1997-02-14 Canon Inc 濃度センサー
JP2008086705A (ja) * 2006-10-05 2008-04-17 Sanyo Electric Co Ltd 測定補助材およびそれを用いた光学測定方法
JP2010227558A (ja) * 2009-03-05 2010-10-14 Yokogawa Electric Corp 成分測定装置

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JPWO2016002560A1 (ja) 2017-04-27

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