WO2016002356A1 - Dispositif de mesure - Google Patents

Dispositif de mesure Download PDF

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Publication number
WO2016002356A1
WO2016002356A1 PCT/JP2015/063875 JP2015063875W WO2016002356A1 WO 2016002356 A1 WO2016002356 A1 WO 2016002356A1 JP 2015063875 W JP2015063875 W JP 2015063875W WO 2016002356 A1 WO2016002356 A1 WO 2016002356A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
wavelength
translucent member
light emitting
optical axis
Prior art date
Application number
PCT/JP2015/063875
Other languages
English (en)
Japanese (ja)
Inventor
右一 佐藤
勉 篠崎
悠平 福島
西村　望
敏晶 深井
Original Assignee
日本電気株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日本電気株式会社 filed Critical 日本電気株式会社
Priority to JP2016531175A priority Critical patent/JPWO2016002356A1/ja
Publication of WO2016002356A1 publication Critical patent/WO2016002356A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light

Definitions

  • the present invention relates to a measuring apparatus that measures specific components using light.
  • Patent Document 1 discloses an apparatus for measuring a blood sugar level in blood.
  • a light source, a light receiving element, and a waveguide are provided on the upper surface of the base portion. And a part of waveguide is exposed to the lower surface of a base part, and the light which the light source produced
  • reflected light is incident on this part. The incident reflected light is guided to the light receiving element.
  • Patent Document 2 describes that light is irradiated in an oblique direction with respect to the surface of the skin, and a plurality of light receiving portions are arranged obliquely and spaced apart.
  • the technique described in Patent Document 2 is intended to measure glucose contained in skin and blood.
  • Patent Document 3 it is described that light is irradiated in an oblique direction with respect to the surface of the skin, and the light receiving portion is disposed obliquely.
  • a patch is applied to the skin. Then, for example, the amount of glucose in the dermis layer is measured by pressing a measuring device against this patch.
  • An object of the present invention is to make it possible to control the depth of a measurement site with high accuracy when measuring a sugar content contained in an interstitial fluid.
  • a housing having an opening in part; A translucent member that is located in the opening and transmits light of the first wavelength; A light emitting means that is disposed inside the housing and emits light including a first wavelength obliquely to the light transmitting member with respect to an outer surface of the light transmitting member; An optical axis disposed inside the casing in a direction passing through the translucent member and detecting light of the first wavelength; With There is provided a measuring apparatus in which the optical axis of the light detecting means and the optical axis of the light emitting means intersect outside the light transmitting member, and the distance between the intersection and the outer surface of the light transmitting member is 2 mm or less.
  • the depth of the measurement site when measuring sugar contained in the interstitial fluid of the skin, the depth of the measurement site can be controlled with high accuracy.
  • each component of the measuring apparatus 10 is not a hardware unit configuration but a functional unit block.
  • the control unit 150 and the calculation unit 160 are arbitrary CPUs, memories, programs loaded in the memory, storage media such as a hard disk for storing the programs, and network and network interface interfaces. Realized by a combination of There are various modifications of the implementation method and apparatus.
  • FIG. 1 is a diagram illustrating a configuration of a measurement apparatus 10 according to the first embodiment.
  • the measuring apparatus 10 includes a housing 100, a translucent member 110, a light emitting unit 120, and a light detecting unit 140.
  • the housing 100 is provided with an opening 102.
  • the translucent member 110 is located in the opening 102 and transmits light of the first wavelength.
  • the light emitting unit 120 and the light detection unit 140 are disposed inside the housing 100.
  • the light emitting unit 120 irradiates (emits) light including the first wavelength toward the translucent member 110 and radiates obliquely toward the outer surface of the translucent member 110.
  • the light detection unit 140 is disposed at a position for receiving light reflected from the light emitted from the light emitting unit 120 at a position where the distance from the outer surface of the translucent member 110 is 2 mm or less.
  • the light detection unit 140 is disposed in a direction in which the optical axis passes through the translucent member 110 and detects light having the first wavelength.
  • the light detection unit 140 measures the intensity of the first wavelength light.
  • the optical axis of the light detection unit 140 is defined as a line that passes through the center of the light receiving surface of the light detection unit 140 and is perpendicular to the light receiving surface of the light detection unit 140, for example.
  • optical axis of the light emission part 120 and the optical axis of the light detection part 140 cross
  • the measuring device 10 is a device that measures a sugar content (for example, glucose) contained in an interstitial fluid of living skin, for example, dermal tissue.
  • the first wavelength is in the near infrared region (for example, 1200 nm or more and 3000 nm or less).
  • the measuring apparatus 10 is used in the state which pressed the translucent member 110 on skin.
  • the housing 100 is formed using, for example, resin or metal.
  • An opening 102 is provided on one surface of the housing 100.
  • the housing 100 may be composed of a plurality of parts.
  • the opening 102 is blocked by the translucent member 110.
  • a part of the housing 100 is constituted by the translucent member 110.
  • the translucent member 110 is a plate-like member made of, for example, glass or resin, and transmits light having the first wavelength.
  • the translucent member 110 is not deformed when pressed against the measurement site.
  • the translucent member 110 also has a function of extending the wrinkles at the measurement site.
  • the translucent member 110 may be a flat plate or may be slightly curved.
  • the housing 100 may be configured by a plurality of members.
  • the light emitting unit 120 has a light emitting element such as an LED or a laser diode as a light source. This light source preferably emits light of the first wavelength stronger than light of other wavelengths.
  • the optical axis of the light emitting unit 120 is disposed obliquely with respect to the outer surface of the translucent member 110. For this reason, when the translucent member 110 of the housing
  • the light detection unit 140 has a photoelectric conversion element such as a photodiode. This photoelectric conversion element preferably has higher sensitivity to light of the first wavelength than sensitivity of light of other wavelengths.
  • the light receiving surface of the light detection unit 140 is disposed obliquely with respect to the outer surface of the translucent member 110.
  • the optical axis of the light detection unit 140 is disposed obliquely with respect to the outer surface of the translucent member 110, and intersects the optical axis of the light emitting unit 120 outside the translucent member 110.
  • the distance d between the intersection ⁇ of the two optical axes and the outer surface of the translucent member 110 is 2 mm or less, preferably 1.5 mm or less.
  • the distance d is preferably 0.5 mm or more.
  • the angle ⁇ formed by the two optical axes is, for example, 60 ° or more and 120 ° or less.
  • the angle formed by the optical axis of the light emitting unit 120 with respect to the outer surface of the light transmissive member 110 and the angle formed by the optical axis of the light detecting unit 140 with respect to the outer surface of the light transmissive member 110 are preferably equal to each other.
  • the translucent member 110 is pressed against the skin of the living body.
  • the light emitting unit 120 emits light.
  • the light emitted from the light emitting unit 120 enters at least the dermis tissue of the skin and is scattered by the cell wall or the like.
  • the light detection unit 140 detects a part of the scattered light.
  • a part of this light is absorbed by a specific component in the skin, for example, sugar such as glucose contained in the interstitial fluid. . Therefore, the concentration of a specific component in the skin can be calculated based on the light intensity detected by the light detection unit 140.
  • the epidermis contains glucose, but this glucose concentration is difficult to follow the glucose concentration in the blood.
  • the subcutaneous tissue is mainly composed of adipose tissue, the glucose concentration is low. For this reason, the light from the light emitting unit 120 needs to be scattered at an appropriate depth after entering the skin.
  • the intersection ⁇ between the optical axis of the light emitting unit 120 and the optical axis of the light detecting unit 140 is always from the surface of the skin. Located at depth d. d is 2 mm or less, preferably 1.5 mm or less. For this reason, the light detected by the light detection unit 140 includes many components scattered at an appropriate depth in the skin. Therefore, when the concentration of a specific component in the skin is calculated based on the light intensity detected by the light detection unit 140, the reliability of the calculation result is improved.
  • FIG. 2 is a diagram illustrating a configuration of the measurement apparatus 10 according to the second embodiment.
  • the measurement apparatus 10 according to the present embodiment has the same configuration as the measurement apparatus 10 according to the first embodiment except for the following points.
  • the light emitting unit 120 includes a light source 122 and a lens 124.
  • the light source 122 has the light emitting element shown in the first embodiment.
  • the lens 124 condenses the light from the light source 122.
  • a condensing point of light from the light source 122 by the lens 124 is located outside the translucent member 110.
  • the distance of this condensing point and the outer surface of the translucent member 110 is 2 mm or less, Preferably it is 1.5 mm or less, and Preferably it is 0.5 mm or more.
  • this condensing point may overlap with the optical axis of the light detection unit 140. However, when the distance between the above-described condensing point and the outer surface of the translucent member 110 is greater than 2 mm, the optical axis of the light detection unit 140 does not overlap the above-described condensing point.
  • the measuring apparatus 10 includes a control unit 150, a calculation unit 160, a display unit 170, and an input unit 180.
  • the input unit 180 is operated by the user of the measuring apparatus 10.
  • the input unit 180 is, for example, a push type or contact type switch, and is located on the outer surface of the housing 100.
  • the control unit 150 causes the light emitting unit 120 to emit light when input is made to the input unit 180.
  • the calculation unit 160 calculates the amount or concentration of the specific component in the detection target, for example, the amount or concentration of sugar (for example, glucose) contained in the interstitial fluid of the skin, according to the detection result of the light detection unit 140. Then, the calculation unit 160 causes the display unit 170 to display the calculated result. Since the display unit 170 is located on the outer surface of the housing 100, the user of the measurement apparatus 10 can recognize the measurement result obtained by the measurement apparatus 10 by viewing the display unit 170.
  • sugar for example, glucose
  • the same effect as that of the first embodiment can be obtained.
  • the distance between the condensing point of the light from the light source 122 by the lens 124 and the outer surface of the translucent member 110 is 2 mm or less, preferably 1.5 mm or less. For this reason, the intensity
  • FIG. 3 is a diagram illustrating a configuration of the measurement apparatus 10 according to the third embodiment.
  • the measuring apparatus 10 according to the present embodiment has the same configuration as the measuring apparatus 10 according to the first embodiment or the second embodiment except that the wavelength filter 190 is provided.
  • FIG. 3 shows a case similar to that of the second embodiment.
  • the wavelength filter 190 is disposed in front of the light detection unit 140, transmits light of the first wavelength, and cuts light of other wavelengths. Thereby, light other than the first wavelength is cut from the light incident on the light detection unit 140.
  • the wavelength filter 190 may be arranged in front of the light emitting unit 120 instead of in front of the light detecting unit 140.
  • the wavelength filter 190 may be disposed in front of the light detection unit 140 and in front of the wavelength filter 190, respectively.
  • the same effects as those in the first or second embodiment can be obtained.
  • the measurement accuracy by the measurement apparatus 10 is further improved.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne un dispositif de mesure (10) qui comprend un boîtier (100), un élément de transmission de lumière (110), une unité d'émission de lumière (120) et une unité de détection de lumière (140). Le boîtier (100) comprend une ouverture (102). L'élément de transmission de lumière (110) est situé dans l'ouverture (102) et permet à la lumière comprenant une première longueur d'onde de traverser celle-ci. L'unité d'émission de lumière (120) et l'unité de détection de lumière (140) sont disposées à l'intérieur du boîtier (100). L'unité d'émission de lumière (120) projette la lumière comprenant une première longueur d'onde vers l'élément de transmission de lumière (110), en diagonale par rapport à la surface extérieure de l'élément de transmission de lumière (110). L'unité de détection de lumière (140) est disposée dans une direction telle que son axe optique traverse l'élément de transmission de lumière (110), et l'unité de détection de lumière mesure l'intensité de la lumière comprenant une première longueur d'onde. Les axes optiques de l'élément d'émission de lumière (120) et l'unité de détection de lumière (140) se coupent à l'extérieur de l'élément de transmission de lumière (110), et une distance (d) entre le point d'intersection (α) et la surface extérieure de l'élément de transmission de lumière (110) est inférieure ou égale à 2 mm.
PCT/JP2015/063875 2014-07-03 2015-05-14 Dispositif de mesure WO2016002356A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2016531175A JPWO2016002356A1 (ja) 2014-07-03 2015-05-14 測定装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014138026 2014-07-03
JP2014-138026 2014-07-03

Publications (1)

Publication Number Publication Date
WO2016002356A1 true WO2016002356A1 (fr) 2016-01-07

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Application Number Title Priority Date Filing Date
PCT/JP2015/063875 WO2016002356A1 (fr) 2014-07-03 2015-05-14 Dispositif de mesure

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JP (1) JPWO2016002356A1 (fr)
WO (1) WO2016002356A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190048706A (ko) * 2017-10-31 2019-05-09 주식회사 템퍼스 혈당 측정 장치

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008154873A (ja) * 2006-12-25 2008-07-10 Sanyo Electric Co Ltd 光学測定装置
JP2012085878A (ja) * 2010-10-20 2012-05-10 Seiko Epson Corp 濃度定量装置及び濃度定量方法並びにプログラム
WO2014054488A1 (fr) * 2012-10-01 2014-04-10 国立大学法人香川大学 Dispositif de mesure de caractéristique spectrale

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008154873A (ja) * 2006-12-25 2008-07-10 Sanyo Electric Co Ltd 光学測定装置
JP2012085878A (ja) * 2010-10-20 2012-05-10 Seiko Epson Corp 濃度定量装置及び濃度定量方法並びにプログラム
WO2014054488A1 (fr) * 2012-10-01 2014-04-10 国立大学法人香川大学 Dispositif de mesure de caractéristique spectrale

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190048706A (ko) * 2017-10-31 2019-05-09 주식회사 템퍼스 혈당 측정 장치
KR101981632B1 (ko) * 2017-10-31 2019-05-24 주식회사 템퍼스 혈당 측정 장치

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