WO2015196950A1 - Synergic insecticide and acaricide composition - Google Patents

Abstract

Provided is an insecticide and acaricide composition. The composition comprises two active components, A and B. Active component A is acrinathrin, and active component B is selected from fenpyroximate, the weight ratio between the two components being 1:30 to 30:1. Also provided are a preparation method for the composition and a use of the composition. Experiment results show that the insecticide composition provided in the present invention has substantial synergy, reduces dosage, and lowers prevention cost. The insecticide and acaricide composition effectively prevents multiple types of pests of fruit trees, vegetables, and cash crops. By compounding insecticides of different action mechanisms and modes, the dosages of individual agents are effectively reduced, thereby expanding the insecticide controlling spectrum, delaying drug resistance of the pests, and enhancing prevention.

Description

Synergistic insecticidal and acaricidal composition Technical field

The present invention relates to an insecticidal and acaricidal composition having improved properties, and more particularly to an insecticidal and acaricidal composition comprising a flumethrin and an oxazolidine, and belongs to the field of pesticide preparations.

Background technique

Acerithrin is a high-efficiency, low-toxic, broad-spectrum, novel pyrethroid-killing insecticide and insecticide. It has good activity against a variety of food-borne pests, and also has good activity against pests and lepidopteran pests such as hibiscus, leaf miner, thrips and aphids. Used in crops such as cotton, fruit trees, soybeans, corn, vegetables, tea, grapes, citrus, and tobacco.

Fenpyroximate is a novel phenoxypyrazole acaricide. The unique E-body structure has higher killing activity and faster speed than the common Z-body structure. Add special additives to inhibit the synthesis of fat in the sputum. It has no cross-resistance with existing acaricides and is suitable for the control of harmful mites that are resistant to existing acaricides. It has a wide spectrum of killing and has the effect of killing insects and diseases. The killing speed is fast, the egg is young and kills, the effect period is long, low toxicity, low residue and good safety. It is suitable for the control of red leafhopper and whole claw leafhopper on a variety of plants.

Studies have shown that long-term repeated and specific application of an active compound to control pests will in many cases lead to increased resistance of pests. To reduce pest resistance, mixtures of different active compounds are currently commonly used to control pests. By combining active compounds having different action mechanisms, resistance can be delayed, application amount can be reduced, control effect can be improved, and control cost can be reduced.

Summary of the invention

The purpose of the invention is to screen the two insecticidal and acaricidal agents with different action principles for the resistance problem of the insecticide and acaricide in the practical application, so as to improve the effect of prevention and treatment, reduce the application amount and expand the use. range.

To achieve the above object, the present invention provides a group of insecticidal and acaricidal compositions comprising two active ingredients A and B, active ingredient A being flumethrin and active ingredient B being oxazolidine. The inventors found through experiments that the above-mentioned insecticidal composition has obvious synergistic effect, and the application amount is reduced, which can reduce the use cost. The compounds containing component A and component B have different structural types and different mechanisms of action. The combination of the two can broaden the spectrum of action and can delay the generation of insect resistance to a certain extent, and component A and component B There is no cross-resistance.

The present invention provides compositions comprising two active ingredients A and B and their use in controlling agricultural pests in the agricultural sector.

The composition of the present invention comprises two active components A and B, and the weight ratio between the two components is from 1:30 to 30:1, preferably from 1:20 to 20:1 by weight, and further preferably the weight ratio is 1. : 10 to 10:1. In some embodiments, the two active components A and B can be selected from 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1 : 1, 1, 2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9 and other more specific ratios.

The composition may be prepared by using the active component together with the pesticide-acceptable adjuvant to prepare any dosage form suitable for agricultural use. Specifically, it may be supplemented with the active ingredient and the auxiliary agent, solvent, commonly used in the pesticide preparation. The carrier auxiliary component is formulated into various dosage forms suitable for use in agriculture.

When the composition is formulated into a specific dosage form, the mass content of the active ingredient is from 1 to 99%, preferably from 1 to 90%, further preferably from 5 to 85%, further from 10 to 55%, most preferably from 10 to 35. %.

The composition of the present invention can be prepared into various dosage forms by known methods, and the active ingredient and auxiliary agents such as a solvent, a solid carrier, and, if necessary, a surfactant or other components (e.g., solvent, carrier, etc.) can be used. The mixture is uniformly mixed and ground to prepare a desired dosage form.

Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, adhesives, surfaces. The active agent or fertilizer may be selected one or more.

The above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings. Alkenes or paraffins, alcohols and glycols and their ethers and esters, such as ethanol, ethylene glycol, ethylene glycol monomethyl; ketones, such as cyclohexanone, highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide, and vegetable or vegetable oils such as soybean oil.

The abovementioned carriers (especially solid carriers), such as for powders and dispersible agents, are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay. In order to manage the physical properties of the composition, it is also possible to add a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier, such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand. In addition, a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.

Suitable surfactants according to the chemical nature of the active ingredient in the composition of the present invention are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene polyglycol ether, three Stearyl phenyl polyglycol ether, alkyl aryl polyether alcohol, ethoxylated castor oil, polyoxyethylene alkyl ether, Ethylene oxide condensate, ethoxylated polyoxypropylene, lauric acid polyethylene glycol ether acetal, sorbitol ester, lignin sulfite waste liquid and methyl cellulose.

The method of application of the compositions of the present invention comprises the use of the compositions of the present invention in aerial parts of plants, including leaves or foliage. The plant's growth site, such as wheat, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant. In vivo (systemic action).

These compositions may be applied only by the active ingredient or may be used in combination with the additives, and thus the compositions of the present invention may be prepared in various dosage forms such as wettable powders, water-dispersible granules, aqueous emulsions, microemulsions. Depending on the nature of the compositions and the intended purpose and environmental conditions to which the compositions are to be applied, the compositions may be applied by spraying, misting, dusting, spreading or pouring, and the like.

The two active ingredients in the compositions of the present invention exhibit synergistic effects and are more pronounced than the individual activities of the individual compounds. The synergistic effect is manifested by allowing for a reduced application rate, a broader insecticidal spectrum, a quicker effect, a more durable control effect, better control of the pest by only one or a few applications, and a widening of the possible application intervals. These characteristics are very important to solve the ubiquitous resistance problem of a single pesticide.

The insecticidal composition of the invention can be applied to the agricultural field for controlling crop pests, especially for various crops such as wheat, cotton, corn, soybean, vegetable, fruit tree (especially citrus, etc.) It has good activity, especially for crop insect pests caused by red spider.

The other characteristics of this product are mainly as follows: 1. It can be applied to various possible application methods such as spraying, seed dressing and mixed soil spreading; 2. The chemical composition of the two single agents of the composition is very different. The mechanism is completely different, there is no cross-resistance, and the resistance problem caused by the separate use of the two single agents can be delayed; 3. The compounding of the composition of the invention has obvious synergistic effect, and the crop is safe and effective. It has been proved by experiments that the composition of the invention has stable chemical properties, remarkable synergistic effect, and exhibits obvious synergistic effect and complementary effect on the control object.

detailed description

In order to make the objects, technical solutions and advantages of the present invention more comprehensible, the present invention will be further described in detail below with reference to the embodiments. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the scope of the invention.

The percentages in all formulations in the following examples are percentages by weight. The processing techniques of the various formulations of the compositions of the present invention are all prior art and may vary depending on the circumstances.

First, the dosage form preparation example

(1) Processing and examples of microemulsions

After completely dissolving the active ingredient flumethrin and oxazolidine in a solvent, stirring, adding emulsifier, synergist and Antifreeze, after the above system is mixed, the water is slowly added to the above mixture, and after fully stirring, different amounts of microemulsion can be formulated.

Example 1:11% flumethrin·oxazolyl microemulsion

Flumethmethone 10%, oxazolidine 1%, methanol 14%, fatty acid polyoxyethylene ester and phenethyl phenol ethoxylate 5%, sodium nitrophenolate 0.5%, urea 2%, water to 100% .

Example 2: 11% flumethrin·oxazolyl microemulsion

1% flumethrin, 10% oxazolidine, 18% ethyl acetate, 15% alkyl benzene sulfonate and alkyl naphthalene sulfonate, 0.8% thiazolone, 2% propylene glycol, water up to 100%.

(2) Processing and examples of water emulsion

In the emulsifier, the active ingredient flumethrin and oxazolidine are mixed with the solvent and the auxiliary agent under mechanical stirring, then the emulsifier and the stabilizer are added to be evenly stirred, and finally water is added at 100-12000 rpm. Stir at a speed of 10-30 minutes to make it a homogeneous milky product.

Example 3: 21% flumethrin oxazol ester water emulsion

Flumethmethone 20%, oxazolidine 1%, propylene glycol 2%, polyisosuccinic anhydride-polyethylene glycol copolymer 2%, xanthan gum 3%, silicone defoamer 1.5%, polyoxyethylene embedded The copolymer was 2% and the water was made up to 100%.

Example 4: 21% flumethrin oxazol ester water emulsion

1% flumethrin, 20% oxazolidine, 2% polyoxyethylene ether of castor oil, 1.8% polyvinyl alcohol, 2% sodium benzoate, 1% N-dodecylpyrrolidone, 2% glycerol, different Octanol 3%, water to 100%.

(III) Processing and examples of suspending agents

The active ingredients of flumethrin and oxazolidine are mixed with the dispersing agent, stabilizer, antifoaming agent and solvent in the proportion of the formula, ground in a sanding kettle, and sent to a homomixer for mixing. Get the finished product evenly.

Example 5: 31% flumethrin oxazolidine suspension

Flumethmethone 30%, oxazolidine 1%, sodium lignosulfonate 11%, silica aerogel 5%, magnesium silicate aluminum 1%, castor oil to 100%.

Example 6: 31% flumethrin oxazolidine suspension

1% of flumethrin, 30% of oxazolidine, 7% of opened powder, 8% of bentonite, 1% of organic silicone, and 100% of engine oil.

Example 7: 12% flumethrin oxazolidine suspension

Flumethmethrin 6%, oxazolidine 6%, sodium lignin sulfonate 9%, bentonite 5%, xanthan gum 2%, silicone defoamer 1.5%, soy oil to 100%.

Second, the efficacy test

(1) Determination of indoor virulence activity

Example 1 flumethrin and oxazolidine complex pairing cotton red spider virulence test

1.1 test drug

Flumethrin original drug, oxazolidine original drug

1.2 Test insect source

Cotton red spider

1.3 Determination method

The leaves without application of insecticide were cut into 5cm in diameter, and the test agents were sprayed evenly on the positive and negative sides of the leaves with a sprayer. After drying, they were transferred to the culture dish and connected to the 2nd instar larvae. Each treatment was 50 times and repeated 4 times. And with water control. The rice was reared at room temperature, 75%-85% relative humidity at 25 °C, and the new rice leaves treated with the drug were replaced every 12 hours. The number of deaths was checked after 48 hours, the mortality was calculated, and the mortality was corrected. Lethal concentration.

1.4 Data Analysis

According to the percentage of active ingredient, flumethrin: oxazol ester ratio: 30:1, 20:1, 10:1, 1:1, 1:10, 1:20, 1:30, according to Sun Yunpei method The virulence index of the agent is the co-toxicity coefficient (CTC).

Measured virulence index (ATI) = (standard drug LC50 / test drug LC50) * 100

Theoretical virulence index (TTI) = A virulence index * Percentage of A in the mixture + B virulence index * Percentage of B in the mixture

Co-toxicity coefficient (CTC) = [mixture measured virulence index (ATI) / mixed theory virulence index (TTI)] * 100

CTC ≤ 80, the composition showed antagonism, 80 < CTC < 120, the composition showed an additive effect, CTC ≥ 120, and the composition showed synergistic effect.

Table 1 Analysis of virulence determination results of flumethrin, oxazolidine and their different ratios in cotton spider mites

The results (Table 1) showed that the control effect of the combination of flumethrin and oxazolidine on cotton spider mites was significantly improved, indicating that the two pairs of cotton red spiders had significant control effects. In particular, the ratio of flumethrin to oxazolidine is between 1:20 and 20:1, and the co-toxicity coefficient of flumethrin and oxazolidine is above 160, and the synergistic effect is obvious.

(2) Field efficacy test

The field efficacy test was repeated 4 times for each treatment, and the whole plant was evenly sprayed at the peak of the occurrence of the damage. Each treatment plot immediately took 5 points, and 10 plants were calibrated at each point. The number of insect populations was investigated before application, and the number of live insects was recorded 5 days after application. The rate of reduction of insects was calculated, that is, the control effect was observed, and the test crops were investigated for drug availability. Symptoms to determine the safety of the agent.

Expected control effect (%) = X + Y-XY / 100 (where X, Y is a single dose control)

Table 2. Results of field control trials of flumethrin and oxazolidine paired with citrus red spider

The results of the determination (Table 2) showed that the combination of flumethrin and oxazolidine significantly improved the control effect of citrus red spider, indicating that the two pairs of citrus red spider had significant synergistic effect. During the entire test, no phytotoxicity to citrus growth was observed in the range of the amount of the composition of the present invention, indicating that the composition of the present invention is safe for citrus growth.

Claims (10)

1. A synergistic pesticidal composition characterized in that the composition comprises two active components A and B, wherein the active component A is flumethrin and the active component B is oxazolidine, between the two components The weight ratio is 1:30 ~ 30:1.
2. The composition according to Claim 1, characterized in that the weight ratio of the active ingredient A flumethrin to the active ingredient B zolyl ester is from 1:20 to 20:1.
3. The composition according to claim 1 or 2, characterized in that the weight ratio of the active ingredient A flumethrin to the active ingredient B oxazolidine is from 1:10 to 10:1.
4. A composition according to Claim 1, 2 or 3, characterized in that the composition is prepared from any of the active ingredients in combination with a pesticidally acceptable excipient.
5. The composition according to claim 4, characterized in that the active ingredient in the dosage form of the composition has a mass content of from 5 to 85%.
6. The composition according to claim 4, wherein the pesticide-acceptable adjuvant comprises an adjuvant, a solvent or a carrier auxiliary component; wherein the adjuvant is selected from the group consisting of minerals, solvents, dispersants, wetting agents, One or more of an adhesive, thickener, binder, surfactant, or fertilizer.
7. The composition according to claim 4 or 5, characterized in that the solvent is selected from the group consisting of xylene, dibutyl phthalate, dioctanoic acid decanoic acid, cyclohexane, paraffin, ethanol, ethylene glycol, ethylene glycol Methyl, cyclohexanone, N-methyl-2-pyrrolidone, dimethyl sulfoxide, dimethylformamide or soybean oil; the carrier is selected from the group consisting of talc, kaolin, montmorillonite, activated clay, pumice, soap Soil, bentonite, calcite, sand or dolomite; the surfactant is lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal salt, amine salt, alkylarylsulfonate, alkyl sulfate, Alkyl sulfonate, fatty alcohol sulfate, fatty acid and sulfated fatty alcohol glycol ether, condensation of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensate of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, polyoxygen Ethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene polyglycol ether, tristearyl phenyl Polyglycol ether, alkyl aryl polyether alcohol, ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensate, ethoxy A polyoxypropylene, a lauric acid polyglycol ether acetal, a sorbitol ester, a lignin sulfite waste liquid or a methyl cellulose.
8. Composition according to claim 4 or 5, characterized in that the dosage form is a wettable powder, a water-dispersible granule, an aqueous emulsion, a microemulsion or a suspending agent.
9. Use of the composition according to any one of claims 1 to 5 for controlling crop pests in the agricultural field.
10. The use according to claim 9, characterized in that the crop pest is a crop pest caused by red spider.