WO2018040764A1

WO2018040764A1 - Herbicide composition having synergistic effect

Info

Publication number: WO2018040764A1
Application number: PCT/CN2017/093189
Authority: WO
Inventors: 仲汉根; 季自华; 季红进
Original assignee: 江苏辉丰农化股份有限公司
Priority date: 2016-08-31
Filing date: 2017-07-17
Publication date: 2018-03-08
Also published as: CN106386817A; CN106386817B

Abstract

A herbicide composition having a synergistic effect is provided. The composition comprises effective components of isoxaflutole and diflufenican, wherein a weight ratio of the isoxaflutole to the diflufenican is 1 : 0.03 to 30. Pharmacodynamic tests show that the composition has positive features such as high complementarity, an obvious synergistic effect, a broader spectrum of weed control, reduced application doses, a prolonged application period, high crop safety, reduced environmental pollution, and being compatible with the environment.

Description

Synergistic herbicidal composition

Technical field

The invention belongs to the field of agricultural plant protection, and in particular relates to a herbicidal composition with improved properties.

Background technique

The active component isoxaflutole is an organic heterocyclic selective systemic pre-emergence herbicide used for soil treatment in dry crop fields such as corn and sugar cane, mainly through the weed roots. And it works. After the sensitive weeds absorb the drug, the formation of chlorophyll is destroyed by inhibiting p-hydroxyphenylacetone dioxygenase, resulting in chlorotic wilting of the affected weeds. Although the active ingredient retained in the surface soil due to poor soil moisture during or after application of isoxaflutole can not be used to prevent weeds in time, it can still be decomposed for a long time. By rain or irrigation, we can still play a role in weed control, and even kill and inhibit sensitive weeds that grow to 4 to 5 leaves. It is mainly used for annual broadleaf weeds, and also has some good control effects on some annual grass weeds such as crabgrass, yarrow grass, goosegrass, thousand gold, big foxtail and foxtail.

The active ingredient diflufenican is a carotenoid biosynthesis inhibitor. Causes chlorophyll destruction and cell rupture, and plant death. It is a broad-spectrum selective wheat field herbicide. The residual period in the soil is longer. It is suitable for controlling pig mites, coiled stalks, purslane, sylvestris, sorghum, nesting vegetables, snails, stalks, sorrel, stalks, thorns, stalks, sedges, toads It contains various broad-leaved weeds such as blue cabbage, wild peas, sage, and small convolvulus, as well as some grass weeds.

Practical pesticide experience has shown that repeated and specific application of one active compound to control weeds will in many cases lead to rapid selectivity of weeds, and mixtures of different active compounds are currently commonly used to control harmful weeds. By combining active compounds having different mechanisms of action, resistance can be delayed, application rates can be reduced, and cost of control can be reduced.

Summary of the invention

The purpose of the invention is to screen the herbicide containing two different weeding principles for the resistance of the herbicide in practical application and the problem of soil residue, so as to improve the control effect of the herbicide, delay the generation of the resistance, and reduce the application amount. Reduce the cost of prevention.

Another object of the present invention is to provide an application of the above composition for controlling weeds in the agricultural field.

The object of the invention can be achieved by the following measures:

The present invention provides a synergistic herbicidal composition comprising the active ingredients A and B, the active ingredient A is isoxaflutole, and the active ingredient B is diflufenic acid.

The inventors found through experiments that the above herbicidal compositions have obvious synergistic effects, and more importantly, the application amount is reduced, and the use cost is lowered. The compounds containing component A and component B have different structural types and different mechanisms of action. The combination of the two can expand the herbicidal spectrum, and can delay the generation and development of weed resistance to some extent, and component A and There is no cross-resistance between component B.

The active ingredient of the composition of the present invention may contain only A and B, and may further contain other active ingredients without affecting the overall performance of the composition.

In one embodiment, the weight ratio of the active ingredient isoxaflutole to diflufenic acid of the herbicidal composition of the invention is from 1:0.03 to 30.

In another embodiment, the weight ratio of the active ingredient of the herbicidal composition of the present invention to isoxaflutole and diflufenic acid is 1:0.05-20.

In another embodiment, the weight ratio of the active ingredient isoxaflutole to diflufenic acid of the herbicidal composition of the invention is from 1:0.1 to 10.

In a preferred embodiment, the weight ratio between the two components of A and B can be arbitrarily adjusted within the range of the following ratios: 1: 0.03, 1: 0.04, 1: 0.05, 1: 0.06, 1: 0.07, 1:0.08, 1:0.09, 1:0.1, 1:0.2, 1:0.3, 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1: 14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:21, 1:22, 1:23, 1:24, 1:25, 1:26, 1:27, 1:28, 1:29, 1:30, it is also possible to select within the range of any two of the above ratios, which can be understood as a weight ratio or a molar ratio.

The composition of the present invention can be formulated into a pesticide-acceptable dosage form together with an active ingredient and an agrochemical adjuvant.

The mass of the active ingredient in the composition of the present invention may be from 2 to 95%, preferably from 5 to 80%.

A carrier, an adjuvant and/or a surfactant may be included in the composition of the present invention. Common auxiliaries can be mixed during the application.

Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers. .

The method of application of the compositions of the invention comprises the use of the compositions of the invention for aerial parts of plants, in particular leaves or foliage. The frequency of administration and the amount administered will depend on the biological and climatic conditions of the pathogen. The plant growth site, such as rice fields, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as In the form of granules (soil application), the composition can be introduced from the soil into the plant through the roots of the plant (systemic action).

These compositions may be applied only by the active ingredient (also referred to as the active ingredient), or may be used in combination with an additive or an auxiliary agent, so that the composition of the present invention can be prepared into various dosage forms such as a wettable powder, a suspending agent, or the like. Dispersing oil suspending agents, water emulsions, emulsifiable concentrates, water-dispersible granules, and the like. Depending on the nature of the compositions and the intended purpose and environmental conditions to which the compositions are to be applied, the compositions may be applied by spraying, misting, dusting, spreading or pouring, and the like.

The composition of the present invention can be prepared into various dosage forms by a known method, for example, the active ingredient and an auxiliary agent such as a solvent, a solid carrier, and if necessary, can be uniformly mixed with a surfactant and ground to prepare a desired form. Formulation.

The above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings. Alkenes or paraffins, alcohols and glycols and their ethers and esters, such as ethanol, ethylene glycol, ethylene glycol monomethyl; ketones, such as cyclohexanone, highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide, and vegetable or vegetable oils such as soybean oil.

The above solid carriers, such as those used in powders and dispersibles, are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay. In order to manage the physical properties of the composition, it is also possible to add a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier, such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand. In addition, a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.

Suitable surfactants according to the chemical nature of the active ingredient in the composition of the present invention are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene polyglycol ether, three Stearyl phenyl polyglycol ether, alkyl aryl polyether alcohol, ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensate, ethoxylated polyoxypropylene, lauric acid poly Glycol ether acetal, sorbitol ester, lignin sulfite waste liquor and methyl cellulose.

The two active ingredients in the compositions of the present invention exhibit synergistic effects, the activity of which is more pronounced than the expected sum of activity using a single compound, and the individual activity of a single compound. The synergistic effect is manifested by allowing for a reduced application rate, a broader herbicidal control profile, quicker effect, longer lasting control effect, better control of weeds by only one or a few applications, and widening of possible application intervals . These characteristics are particularly needed to control weed control practices.

The herbicidal composition of the invention can be applied to the control of crop weeds in the agricultural field, in particular Persian Po Na, Ma Tang, Xiang Fuzi and wild donkey.

The other characteristics exhibited by the herbicidal composition of the present invention are mainly as follows: 1. Since the chemical composition of the two single agents of the present composition is very different, the mechanism of action is completely different, and there is no cross-resistance, and two single agents can be delayed. The resulting resistance problem is used alone; 2. The composition of the present invention is safe and effective against crops. It has been proved by experiments that the herbicide composition of the invention has stable chemical properties, remarkable synergistic effect, and exhibits obvious synergistic effect and complementary effect on the control object.

detailed description

In order to make the objects, technical solutions and advantages of the present invention more comprehensible, the present invention will be further described in detail below with reference to the embodiments. It is understood that the specific embodiments described herein are intended to be illustrative of the invention and are not to be construed as limiting the scope of the invention. Within the scope of protection of the present invention.

The percentages in all formulations in the following examples are percentages by weight. The processing techniques of the various formulations of the compositions of the present invention are all prior art and may vary depending on the circumstances.

First, the dosage form preparation example

(1) Processing and examples of wettable powders

The active ingredient isoxaflutole is mixed with the active ingredient flufenic acid with various auxiliaries and fillers in proportion, and pulverized by an ultrafine pulverizer to obtain a wettable powder.

Example 1: 21% isoxaflutole piracetamide wettable powder

Isoxaflutole 1%, flufenacetate 20%, sodium lignin sulfonate 6%, alkyl sulfonate 5%, white carbon black 8%, kaolin to 100%.

Example 2: 42% isoxaflutole piracetamide wettable powder

Isoxaflutole 40%, flufenacetate 2%, bentonite 3%, alkyl sulfonate 3%, white carbon black 5%, diatomaceous earth supplemented to 100%.

Example 3: 84% isoxaflutole piracetamide wettable powder

Isoxaflutole 14%, flufenacetate 70%, fatty alcohol sulfate 6%, calcite 3%, kaolin 7%, and light calcium carbonate supplemented to 100%.

(2) Processing and examples of water-dispersible granules

Mixing the active ingredient isoxaflutole with flufenic acid, auxiliaries and fillers in a ratio of the formula, pulverizing into a wettable powder by air flow, adding a certain amount of water, mixing and granulating, and drying and sieving A water dispersible granule product is obtained afterwards.

Example 4: 11% isoxaflutole and flufenacetate water-dispersible granules

Isoxaflutole 1%, flufenic acid 10%, sodium benzoate 5%, alkyl polyoxyethyl ether sulfonate 5%, fatty sulfur Ammonium alkoxide 4%, kaolin up to 100%.

Example 5: 20% isoxaflutole and flufenacetate water-dispersible granules

Isooxazolone 10%, flufenic acid 10%, polyoxyethylene octyl phenyl ether 6%, potassium dodecyl sulfonate 4%, sodium lignosulfonate 4%, diatomaceous earth 100%.

Example 6: 31% isoxaflutole and flufenacetate water-dispersible granules

Isoxaflutole 30%, flufenacetate 1%, fatty acid and sulfated fatty alcohol glycol ether 6%, potassium lauryl sulfate 4%, sodium lignosulfonate 3%, lignin calcium carbonate Make up to 100%.

(3) Processing and examples of emulsifiable concentrate

The active ingredient isoxazolone and flufenic acid, emulsifier, organic solvent and other components are mixed in a uniform ratio to obtain a finished product.

Example 7: 31% isoxaflutole piracetamide EC

Isoxaflutole 1%, flufenacetate 30%, propylene glycol 15%, alkyl aryl polyglycol ether 10%, toluene to 100%.

Example 8: 11% isoxaflutole piracetamide emulsifiable concentrate

Isoxaflutole 10%, flufenacetate 1%, ethanol 7%, ethoxylated polyoxypropylene 9%, xylene make up to 100%.

Example 9: 24% isoxaflutole piracetamide emulsifiable concentrate

Isoxaflutole 20%, flufenacetate 4%, sodium methylnaphthalene sulfonate formaldehyde condensate 6%, tributyl phenyl polyglycol ether 15%, toluene to 100%.

Second, the efficacy test

(1) Bioassay examples

Isooxazolone was used as a standard drug to calculate the disease index and control effect. The control effect is converted into the probability value (y), the concentration of the drug solution (μg/ml) is converted into the logarithm value (x), the virulence equation is calculated by the least squares method and the concentration EC50 is suppressed, and the virulence index of the drug is calculated according to the method of Sun Yunpei. Grade Co-toxicity coefficient (CTC). The virulence test results are shown in Table 1.

Measured virulence index (ATI) = (standard drug EC50 / test drug EC50) * 100

Theoretical virulence index (TTI) = A virulence index * Percentage of A in the mixture + B virulence index * Percentage of B in the mixture

Co-toxicity coefficient (CTC) = [mixture measured virulence index (ATI) / mixed theory virulence index (TTI)] * 100

CTC ≤ 80, the composition showed antagonism, 80 < CTC < 120, the composition showed an additive effect, CTC ≥ 120, and the composition showed synergistic effect.

1. The virulence test of the combination of isoxaflutole and flufenacetate in Persian

Table 1 Determination of the virulence of the different ratios of isoxaflutole and flufenacetate to Persian Posner (1)

The results (Table 1) showed that the combination of isoxaflutole and flufenacetamide was between 1 and 30:1 and 30, and the co-toxicity coefficient was above 125, indicating that isoxaflutole in this interval. The complexation with Perfluoxetine with Persian Posner has a significant synergistic effect. Outside this range, the co-toxicity coefficient is less than 120, showing only additive effects.

2. The virulence test of the combination of isoxaflutole and flufenacetate in the maturity (2)

Table 2 Analysis of the virulence test results of the combination of isoxaflutole and flufenacetate

The results (Table 2) showed that the combination of isoxaflutole and diflufenic acid was between 1 and 30:1 to 30, and the co-toxicity coefficient was above 120, indicating that in this interval, isoxaflutole The combination with flufenacetamide in the control of crabgrass has a significant synergistic effect. Outside this range, the co-toxicity coefficient is less than 120, showing only additive effects.

(2) Field efficacy test

1. The field control effect of isoxaflutole and diflufenic acid was verified by the examples prepared by the present invention.

Expected control effect (%) = X + Y-XY / 100 (where X, Y is a single dose control)

Table 3. Field control test results of complex combination of isoxaflutole and flufenic acid with fragrant aconite and wild peony

The results of the determination (Table 3) showed that the combination of isoxaflutole and diflufenic acid against the control of weed aconite and wild carp was significantly improved, indicating that there was significant synergy between the two pairs of miscellaneous aconite and wild locust. Synergies.

Claims

A synergistic herbicidal composition characterized in that the composition contains the active ingredients of isoxaflutole and diflufenic acid.
The herbicidal composition according to claim 1, wherein the weight ratio of the active ingredient isoxaflutole to diflufenic acid is 1:0.03 to 30.
The herbicidal composition according to claim 2, wherein the weight ratio of the active ingredient isoxaflutole to diflufenic acid is 1:0.05 to 20.
The herbicidal composition according to claim 3, wherein the weight ratio of the active ingredient isoxaflutole to diflufenic acid is 1:0.1 to 10.
The herbicidal composition according to claim 1, wherein the composition is formulated into a pesticide-acceptable dosage form together with an active ingredient and an agrochemical adjuvant.
The herbicidal composition according to claim 5, wherein the active ingredient has a mass content of from 2 to 95%.
The herbicidal composition according to claim 6, wherein the active ingredient in the composition has a mass content of from 5 to 80%.
The herbicidal composition according to claim 5, characterized in that the dosage form is a wettable powder, a water-dispersible granule or an emulsifiable concentrate.
Use of the herbicidal composition of claim 1 for controlling crop weeds in the agricultural sector.
The use according to claim 9, characterized in that the weeds are selected from the group consisting of Persian Po, Naanthus, Aconite and Wild.