WO2015098465A1 - Tête de pulvérisation pour instrument pour administrer une solution contenant un médicament biologique - Google Patents

Tête de pulvérisation pour instrument pour administrer une solution contenant un médicament biologique Download PDF

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Publication number
WO2015098465A1
WO2015098465A1 PCT/JP2014/082232 JP2014082232W WO2015098465A1 WO 2015098465 A1 WO2015098465 A1 WO 2015098465A1 JP 2014082232 W JP2014082232 W JP 2014082232W WO 2015098465 A1 WO2015098465 A1 WO 2015098465A1
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WO
WIPO (PCT)
Prior art keywords
tube
solution
nozzle
discharge port
containing solution
Prior art date
Application number
PCT/JP2014/082232
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English (en)
Japanese (ja)
Inventor
正紀 池ノ上
洋一郎 河野
Original Assignee
ニプロ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by ニプロ株式会社 filed Critical ニプロ株式会社
Priority to JP2015554711A priority Critical patent/JPWO2015098465A1/ja
Publication of WO2015098465A1 publication Critical patent/WO2015098465A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
    • B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00522—Sprayers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
    • B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
    • B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet

Definitions

  • the present invention relates to a spray head (hereinafter also simply referred to as a spray head) for a biomedical drug-containing solution administration device for spray-administering a biomedical drug-containing solution, which is a solution containing a biomedical drug, to a living tissue. More specifically, the present invention relates to a spray head provided in a biomedical drug-containing solution administration device that enables a biomedical drug-containing solution to be sprayed outward by using a compressed gas.
  • a spraying method as a method for administering a biomedical drug that is preferably used during procedures such as craniotomy, thoracotomy, and open-space surgery.
  • a biomedical agent is prepared in a solution, and the solution is spray-administered to a living tissue.
  • biomedical agents administered using this spraying method such as bioadhesives, cleaning agents (such as physiological saline), and drugs having medicinal properties.
  • the bioadhesive will be described as an example.
  • bioadhesives based on animal proteins are used.
  • the bioadhesive mainly composed of animal protein has a solution containing animal protein as a solution containing bioadhesive component and a coagulation factor that promotes coagulation of animal protein as solution containing bioadhesive component. It is a so-called two-part adhesive exhibiting adhesive performance by mixing with a solution containing it.
  • a bioadhesive composed of a solution containing factor XIII and fibrinogen and a solution containing thrombin is widely used. ing.
  • the spray method is suitably used for administration of the above-mentioned bioadhesive component-containing solution, which is a biomedical agent-containing solution (hereinafter also simply referred to as a solution), to a living tissue.
  • the spray method is to atomize the solution by discharging a solution from a solution discharge port and discharging a compressed gas from a gas discharge port provided adjacent to the solution discharge port so as to surround the solution discharge port.
  • This is a method of administration to a living tissue in a compressed gas, and is superior to other administration methods in that a solution can be uniformly administered to a living tissue.
  • a pair of biomedical drug-containing solution administration devices (hereinafter also simply referred to as administration devices) each filled with the above-described two types of solutions are prepared, and any of the following two administration methods is prepared. These two types of solutions are spray-administered to living tissue.
  • the first method is a method in which the two types of solutions are sprayed and administered simultaneously to a living tissue from a pair of prepared administration devices.
  • the two types of solutions are mixed while the two types of solutions are mixed. Will be applied to the tissue.
  • the second method uses one of the prepared pair of administration tools to spray and administer one solution to the living tissue, and then uses the other of the prepared pair of administration tools to direct the other solution to the living tissue.
  • the two kinds of solutions are individually applied to the living tissue, and the two kinds of solutions are mixed on the living tissue.
  • Patent Document 1 Japanese Patent Laid-Open No. 2003-10330 is a document that specifically discloses the configuration of an administration device used when the above-described spraying method is used.
  • the administration device disclosed in Japanese Patent Application Laid-Open No. 2003-10330 includes a syringe filled with a solution, a compressor that pumps compressed air as a compressed gas, and a spray head connected to the syringe and the compressor. Yes.
  • the spray head is attached to a syringe and a compressor, and is attached to a tube having a double tube structure capable of transporting the solution and compressed air as compressed gas in a separated state, and in the vicinity of the tip of the tube.
  • the solution discharge port and the gas discharge port described above are both provided at the tip portion on the side where the nozzle is located.
  • a tube having a double tube structure including an inner tube and an outer tube has a predetermined length (for example, about several tens of centimeters).
  • the inner tube and the outer tube are made of a metal tube and a plastic, respectively, so that the tube having the double tube structure is freely deformed and its shape is generally maintained. It consists of a tube made.
  • the nozzle described above is configured by a hollow cylindrical body in which a plurality of grooves extending along the axial direction are formed on the inner peripheral surface.
  • An outer tube which is a plastic tube, is fitted to the rear end of the nozzle, and an inner tube, which is a metal tube, is inserted through the hollow portion of the nozzle.
  • the nozzle described above is attached in the vicinity of the tip of the tube having a double tube structure.
  • the tip of the inner tube made of a metal tube forming the solution discharge port is disposed so as to slightly protrude (for example, about 1 mm) from the tip surface of the nozzle.
  • the gas discharge port is provided on the tip surface of the nozzle so as to surround the inner tube made of a metal tube.
  • the compressed gas (compressed air) conveyance path provided inside the tube having a double-pipe structure and the gas discharge port provided on the tip surface of the nozzle are provided on the inner peripheral surface of the nozzle described above.
  • the surface of the groove portion communicates with a passage defined by the outer peripheral surface of the inner tube made of a metal tube.
  • the spray head disclosed in the above Japanese Patent Application Laid-Open No. 2003-10330 when a tube having a double tube structure is deformed, the bending of the inner tube made of a metal tube and the outer tube made of a plastic tube. Due to the difference between the degree of bending and the degree of bending, the amount of protrusion at the tip of the inner tube made of the metal tube that protrudes from the tip of the nozzle is changed.
  • the present invention has been made to solve the above-described problems, and is for a biomedical drug-containing solution administration device having a simple configuration that can reliably obtain a desired spray performance even when a tube is deformed.
  • An object of the present invention is to provide a spray head.
  • a spray head for a biomedical drug-containing solution administration device is a spray head for a biomedical drug-containing solution administration device that sprays a biomedical drug-containing solution toward the outside by using a compressed gas,
  • a tube that conveys the biomedical drug-containing solution and compressed gas in a state where they are separated, and a biomedical drug-containing solution and compressed gas that are attached to the tip of the tube and are introduced from the tube in a state where they are separated.
  • a nozzle for discharging toward the outside In the tube, compressed gas is conveyed between the inner tube in which a solution conveyance path for conveying a biomedicine-containing solution is provided and the inner tube by being inserted into the inner tube.
  • the nozzle has a double-pipe structure composed of an outer tube that defines a gas conveyance path.
  • the inner tube is made of a member that is freely deformed when an external force is applied and whose shape is generally maintained when the external force is removed, and the outer tube is made of an elastically deformable member.
  • the nozzle includes a first fitting portion in which a tip of the inner tube is fitted, and a second fitting portion in which the tip of the outer tube is fitted.
  • the nozzle end surface is provided with a solution discharge port for discharging the biomedicine-containing solution and a gas discharge port for discharging compressed gas, and the gas discharge port is the solution discharge port. Is disposed so as to surround.
  • a solution passage for communicating the solution conveyance path and the solution discharge port
  • a gas passage for communicating the gas conveyance path and the gas discharge port.
  • the solution passage and the gas passage are separated by a partition wall formed by a part of the nozzle.
  • a protruding portion protruding outward may be provided on the tip surface of the nozzle, and in that case, the solution It is preferable that a discharge port is provided at the tip of the protrusion.
  • the inner tube is fixed to the nozzle by press-fitting the tip of the inner tube into the first fitting portion. It is preferable.
  • the first fitting portion is located closer to the tip surface than the second fitting portion.
  • the inner tube is preferably made of a metal member, and the outer tube is made of a resin member. Is preferred.
  • a spray head for a biomedical drug-containing solution administration device having a simple configuration capable of reliably obtaining desired spray performance even when the tube is deformed.
  • FIG. 5 is an enlarged cross-sectional view along the line VA-VA shown in FIG.
  • FIG. 5 is an enlarged sectional view taken along line VB-VB shown in FIG.
  • FIG. 5 is an enlarged cross-sectional view along the line VC-VC shown in FIG. 4.
  • FIG. 5 is an enlarged cross-sectional view along the line VD-VD shown in FIG. 4. It is a front view of the nozzle seen from the arrow VI side shown in FIG.
  • FIG. 1 is a side view of a spray head and a biomedical drug-containing solution administration device equipped with the same according to an embodiment of the present invention.
  • the structure of the biomedicine containing solution administration device provided with the spray head in this Embodiment is demonstrated.
  • the biomedical drug-containing solution administration device 100 includes a spray head 1, a syringe 110, and a compressor (not shown).
  • the syringe 110 is connected to the spray head 1 via a connector 40 (described later) provided on the spray head 1, and a compressor (not shown) is connected to the spray head 1 via an air pipe (not shown).
  • the syringe 110 is formed by filling a biopharmaceutical-containing solution, which is a solution containing a biomedical agent, and includes a barrel 111 and a plunger 112 that is slidably assembled to the barrel 111. ing.
  • the syringe 110 supplies the solution to the spray head 1 from the tip of the barrel 111 when the plunger 112 is pushed toward the barrel 111.
  • a compressor (not shown) generates compressed air as compressed gas, and supplies the generated compressed air to the spray head 1 via the air pipe (not shown).
  • FIG. 2 is a perspective view of the spray head shown in FIG. 1
  • FIG. 3 is a cross-sectional view of the spray head shown in FIG. Next, with reference to these FIG. 2 and FIG. 3, the spray head in this Embodiment is demonstrated.
  • the spray head 1 includes a trifurcated tube 10, a tube 20, a nozzle 30, and a connector 40.
  • the tube 20 has a long shape (about several tens of centimeters), a nozzle 30 is attached to the tip thereof, and the trifurcated tube 10 is attached to the rear end thereof.
  • the connector 40 is attached to the rear end of the trifurcated tube 10.
  • the trifurcated tube 10 is a part for receiving the solution supplied from the syringe 110 and the compressed air supplied from the compressor and introducing them into the spray head 1.
  • the third port 13 has a substantially Y-shape.
  • the above-described syringe 110 is connected to the first port 11 via the connector 40, and the above-described compressor (not shown) is connected to the second port 12 via the above-described air pipe (not shown).
  • an outer tube 22 to be described later of the tubes 20 is connected to the third port 13, and an inner tube 21 to be described later of the tubes 20 is trifurcated via the third port 13.
  • the pipe 10 is drawn out from the inside.
  • the trifurcated tube 10 includes a hub 14 therein, and the hub 14 is fitted into the first port 11 of the trifurcated tube 10 described above.
  • the hub 14 has a dome shape that can accept the tip of the barrel 111 of the syringe 110 connected to the trifurcated tube 10 via the connector 40.
  • An opening into which a rear end of an inner tube 21 (described later) of the tubes 20 is inserted is provided at the tip of the hub 14.
  • the trifurcated tube 10 is preferably made of a resin member typified by polypropylene resin, polyethylene resin, polyvinyl chloride resin, polycarbonate resin, ABS resin (acrylonitrile-budadiene-styrene copolymer synthetic resin) or the like. Composed.
  • the hub 14 is preferably made of a resin member typified by polypropylene resin or polystyrene resin.
  • the tube 20 is for conveying the solution introduced from the syringe 110 and the compressed air introduced from the compressor toward the nozzle 30 in a state where they are separated, and is composed of an inner tube 21 and an outer tube 22. Has a heavy pipe structure.
  • the inner tube 21 has a solution transport path 23 through which the solution is transported.
  • a tip of the inner tube 21 is attached to the nozzle 30 and a rear end of the tube is fitted to the hub 14 described above.
  • the outer tube 22 defines a gas conveyance path 24 through which the compressed air is conveyed between the inner tube 21 and the inner tube 21 when the inner tube 21 is inserted into the inner tube 21.
  • the rear end is fitted into the above-described third port 13 of the trifurcated tube 10.
  • the inner tube 21 is composed of a member that can be freely deformed when an external force is applied and whose shape is generally maintained when the external force is removed, such as copper or annealed stainless alloy. It consists of a metal tube made of a metallic material.
  • the outer tube 22 is made of an elastically deformable member, and is made of a resin tube made of a soft resin material typified by polyethylene resin, polyurethane resin, soft polyvinyl chloride resin, or the like.
  • the tube 20 having a double tube structure can be easily and freely changed in shape by hand or the like, and the position and angle of the nozzle 30 attached to the tip of the tube 20 can be changed. It can be adjusted freely. Therefore, it contributes to the convenience of spray administration of the solution.
  • the nozzle 30 is for discharging the solution and compressed air introduced from the tube 20 having a double-pipe structure toward the outside in a state where they are separated, and a solution discharge port 35 for discharging the solution. And a gas discharge port 36 for discharging compressed air on the distal end surface 30a.
  • the tip surface 30a of the nozzle 30 is provided with a protrusion 37 protruding outward at the center thereof, and the above-described solution discharge port 35 is provided at the tip of the protrusion 37. Yes.
  • a plurality of gas discharge ports 36 are provided on the tip surface 30 a of the nozzle 30 so as to surround the solution discharge port 35 provided in the protruding portion 37.
  • the solution discharged from the nozzle 30 is atomized by being entrained in the compressed air discharged from the nozzle 30, and the atomized solution is sprayed outward on the compressed air.
  • the protruding amount of the protruding portion 37 is preferably about ⁇ 3 mm, for example, about 1 mm.
  • the nozzle 30 is preferably composed of a resin member typified by polypropylene resin, polyethylene resin, polyvinyl chloride resin, polycarbonate resin, ABS resin or the like. A more detailed structure of the nozzle 30 will be described later.
  • the connector 40 is for connecting the trifurcated tube 10 and the syringe 110 as described above, and has a cylindrical first connection portion 41 located on the front end side and a cylindrical first end located on the rear end side. 2 connection portions 42.
  • the first connection portion 41 is fitted into the above-described first port 11 of the trifurcated tube 10, and the second connection portion 42 is configured so that the tip portion of the above-described barrel 111 of the syringe 110 can be connected. .
  • FIG. 4 is an enlarged cross-sectional view of region IV shown in FIG. 3, and FIGS. 5A to 5D are taken along lines VA-VA, VB-VB, VC-VC and VD-VD shown in FIG. 4, respectively.
  • FIG. FIG. 6 is a front view of the nozzle viewed from the arrow VI side shown in FIG. Next, with reference to these FIG. 4 thru
  • the inner tube 21 and the outer tube 22 constituting the tube 20 having a double tube structure are both inserted from the rear end side of the nozzle 30 toward the inside of the nozzle 30. It is attached to the nozzle 30 by being inserted.
  • the distal end 21 a of the inner tube 21 is located so as to protrude toward the front side (that is, the left side shown in FIG. 4) with respect to the distal end 22 a of the outer tube 22.
  • the nozzle 30 has a substantially cylindrical shape in which a hollow portion having a predetermined shape is provided so as to extend substantially along the axial direction.
  • a first fitting portion 31 and a second fitting portion 32 are provided.
  • the first fitting portion 31 is a portion to which the tip 21a of the inner tube 21 is fitted, and is configured by a substantially cylindrical portion having an inner diameter corresponding to the outer diameter of the inner tube 21.
  • the first fitting portion 31 holds the inner tube 21 by press-fitting the tip 21a of the inner tube 21 therein.
  • the second fitting portion 32 is a portion to which the distal end 22a of the outer tube 22 is fitted, and is configured by a substantially cylindrical portion having an inner diameter corresponding to the outer diameter of the outer tube 22.
  • the second fitting portion 32 holds the outer tube 22 by press-fitting the distal end 22a of the outer tube 22 therein.
  • the outer diameter of the outer tube 22 is larger than the outer diameter of the inner tube 21, and the inner diameter of the second fitting part 32 is configured to be larger than the inner diameter of the first fitting part 31.
  • the first fitting portion 31 is more distal than the second fitting portion 32. It is provided at a position near 30a.
  • the hollow portion provided inside the nozzle 30 is surrounded by the first fitting portion 31 and the tip 21a of the inner tube 21 is disposed, and is surrounded by the second fitting portion 32 and the outer tube 22.
  • the solution passage 33 provided in the inner tube 21 communicates with the solution discharge port 35 provided in the distal end surface 30a of the nozzle 30, and the outer tube 22
  • a gas passage 34 that communicates the gas conveyance path 24 defined by the inner tube 21 and the gas discharge port 36 provided on the tip end surface 30 a of the nozzle 30.
  • the solution passage 33 is a part for allowing the solution supplied from the solution transport path 23 to flow and reach the solution discharge port 35, and forward from the portion where the first fitting portion 31 described above is provided. It is provided so that it may extend toward.
  • the gas passage 34 is a part for allowing the compressed air supplied from the gas conveyance path 24 to flow and reaching the gas discharge port 36, and the portion where the second fitting portion 32 described above is provided. It is provided so that it may extend toward the front.
  • the gas conveyance path 24 is branched into a plurality of paths at a midway position from the rear end side to the tip end side, and each of the branched paths reaches the plurality of gas discharge ports 36 in association with each other. Is formed.
  • the solution passage 33 and the gas passage 34 are separated by a partition wall 38 formed by a part of the nozzle 30.
  • the solution passage 33 and the gas passage 34 can cause the introduced solution and compressed air to reach the solution discharge port 35 and the gas discharge port 36, respectively, while they are separated. I have to.
  • the nozzle 30 can discharge the solution and compressed air which were introduced from the tube 20 which has a double tube structure toward the exterior in the state which these isolate
  • the spray head 1 not only the outer tube 22 but also the inner tube 21 of the tubes 20 having a double tube structure are fitted to the nozzle 30.
  • the nozzle 30 is provided with a solution passage 33, a gas passage 34, a solution discharge port 35, and a gas discharge port 36. Further, the solution passage 33 and the gas passage 34 are provided with the nozzle 30. It is set as the structure separated by the partition part 38 comprised by one part.
  • the spray head 1 in the present embodiment does not require a particularly complicated structure as compared with a conventional general spray head, it can be manufactured relatively inexpensively and easily.
  • a spray head for a biomedical drug-containing solution administration device having a simple configuration that can reliably obtain a desired spray performance even when the tube is deformed, and can do.
  • the case where the inner tube and the outer tube are respectively fitted to the nozzle is illustrated.
  • the inner tube and the outer tube are fitted to the nozzle.
  • the specific method of wearing is not limited to the press-fitting method.
  • they may be configured to be fitted by locking portions and locking the locking portions to each other, or may be configured to be fitted by using an adhesive or the like.
  • it is good also as employ adopting a different structure for the fitting of an inner tube and a nozzle, and the fitting of an outer tube and a nozzle.
  • the case where the tip of the inner tube is configured to be located behind the tip surface of the nozzle is illustrated, but the tip of the inner tube is flush with the tip surface of the nozzle. It may be configured to reach the position.
  • the solution passage is located only inside the protrusion provided on the tip surface of the nozzle, but in this case also, the protrusion and the first fitting are provided between the solution passage and the gas passage.
  • a part of the nozzle that constitutes the attachment portion is located, and the partition portion that separates the solution passage and the gas passage is constituted by the portion.
  • the spray head for a biomedical drug-containing solution administration device to which the present invention can be applied is for an administration device used for administration of a biomedical agent applied to the human body or an animal. It is envisaged to be used for various purposes, such as for administration devices used for administration of biomedical agents.
  • a spray head for a biomedical drug-containing solution administration device to which the present invention can be applied it is used for an administration device used for administration of a bioadhesive or a cleaning agent (eg, physiological saline).
  • a bioadhesive or a cleaning agent eg, physiological saline
  • biopharmaceutical administration devices such as those for administration devices that are used for administration of drugs having medicinal components, and these different types of biomedical agents
  • application to an administration device for simultaneous administration of a plurality of types is also envisaged.
  • a spray head for a bioadhesive administration device to which the present invention can be applied a spray head for administration of a so-called one-component bioadhesive or a two-component bioadhesive can be used. It is envisaged to be used for various bioadhesive administration devices such as those used for administration devices, and the above-mentioned cleaning agents and the same as these one-component bioadhesives or two-component bioadhesives Naturally, application to an administration device for simultaneously administering drugs having medicinal ingredients is also envisaged.
  • 1 spray head 10 trifurcated tube, 11 1st port, 12 2nd port, 13 3rd port, 14 hub, 20 tube, 21 inner tube, 21a tip, 22 outer tube, 22a tip, 23 solution transport path, 24 Gas transport path, 30 nozzle, 30a tip surface, 31 first fitting portion, 32 second fitting portion, 33 solution passage, 34 gas passage, 35 solution discharge port, 36 gas discharge port, 37 protrusion, 38 partition portion , 40 connector, 41 first connection part, 42 second connection part, 100 biomedical drug-containing solution administration device, 110 syringe, 111 barrel, 112 plunger.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Nozzles (AREA)
  • Surgical Instruments (AREA)

Abstract

　La présente invention concerne une tête de pulvérisation qui est pourvue d'un tube (20) ayant une structure de double tuyau comprenant un tube intérieur (21) capable de se déformer librement et un tube extérieur (22) capable de se déformer librement, et une buse (30). Un trajet de transport de solution (23) et un trajet de transport de gaz (24) sont disposés dans le tube (20), et un orifice de décharge de solution (35) et un orifice de décharge de gaz (36) sont disposés sur le face d'extrémité distale (30a) de la buse (30). Une première partie d'ajustement (31) dans laquelle l'extrémité distale (21a) du tube intérieur (21) est ajustée, une deuxième partie d'ajustement (32) dans laquelle l'extrémité distale (22a) du tube extérieur (22) est ajustée, un passage de solution (33) pour faire communiquer le trajet de transport de solution (23) et l'orifice de décharge de solution (35), et un passage de gaz (34) pour faire communiquer le trajet de transport de gaz (24) et l'orifice de décharge de gaz (36) sont disposés à l'intérieur de la buse (30). Le passage de solution (33) et le passage de gaz (34) sont partagés par une partie de barrière (38) disposée sur la buse (30).
PCT/JP2014/082232 2013-12-27 2014-12-05 Tête de pulvérisation pour instrument pour administrer une solution contenant un médicament biologique WO2015098465A1 (fr)

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JP2013270656 2013-12-27
JP2013-270656 2013-12-27

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JP2002522177A (ja) * 1998-08-14 2002-07-23 インセプト エルエルシー ヒドロゲルのインサイチュ形成のための方法および装置
JP2003010330A (ja) * 2001-07-02 2003-01-14 Nipro Corp 生体接着剤投与用スプレーヘッド

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JP4486036B2 (ja) * 2005-12-14 2010-06-23 テルモ株式会社 塗布具
JP5779467B2 (ja) * 2011-09-30 2015-09-16 住友ベークライト株式会社 生体組織接着剤塗布用具およびノズルヘッド

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