WO2015068575A1 - 体液採取用デバイス - Google Patents
体液採取用デバイス Download PDFInfo
- Publication number
- WO2015068575A1 WO2015068575A1 PCT/JP2014/078085 JP2014078085W WO2015068575A1 WO 2015068575 A1 WO2015068575 A1 WO 2015068575A1 JP 2014078085 W JP2014078085 W JP 2014078085W WO 2015068575 A1 WO2015068575 A1 WO 2015068575A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- absorber
- lumen
- body fluid
- peripheral surface
- certain amount
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00174—Optical arrangements characterised by the viewing angles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/04—Endoscopic instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150045—Source of blood for blood from vagina, placenta, colon or mouth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
- A61B5/150083—Means for enhancing collection by vibration, e.g. ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150358—Strips for collecting blood, e.g. absorbent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
- A61B1/0676—Endoscope light sources at distal tip of an endoscope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B2010/009—Various features of diagnostic instruments
Definitions
- the present invention relates to a bodily fluid collection device for collecting bodily fluids inserted into a living body.
- This application claims priority based on Japanese Patent Application No. 2013-230309 for which it applied on November 6, 2013, and uses the content here.
- a body fluid collecting device is introduced into a living body to collect a body fluid, and the living body is inspected using the body fluid.
- a bodily fluid collecting tool described in Patent Document 1 includes a long flexible catheter (long shaft member), and a movable absorber unit inserted in a hollow hole of the catheter so as to be able to advance and retract.
- the movable absorber unit is configured by mechanically connecting a shaft-like member formed of a semi-rigid material located on the distal end side and a relatively flexible operation wire located on the proximal end side via a joint.
- the An absorbent body made of a liquid absorbent material is fixed to the distal end of the shaft member.
- This absorber is formed in a spindle shape whose front end is substantially spherical and whose rear end is gradually narrowed.
- the body fluid collecting tool configured as described above is guided to the target site through the endoscope channel.
- the entire absorber is protruded from the distal end of the catheter.
- the present invention has been made in view of such problems, and provides a body fluid collection device that can easily recover an absorbent body in a state where a certain amount of body fluid is absorbed by the absorbent body. With the goal.
- the bodily fluid collection device expands as it absorbs the bodily fluid from the long-axis member having the lumen formed along the longitudinal axis and the initial state in which the bodily fluid is not absorbed. And an absorber having a base end portion disposed in the lumen when the body fluid is absorbed in a certain amount, and an identification unit for identifying that the absorber has absorbed the body fluid in a certain amount. .
- the identification unit is provided on the long shaft member so as to be observable from the outer peripheral surface side. It may be ground glass whose peripheral surface is a ground surface.
- the absorber In the initial state, the absorber may have an outer diameter that is equal to or smaller than the inner diameter of the lumen, and may be disposed on the tip side of the ground surface. When a certain amount of the body fluid is absorbed, the outer diameter of the absorber becomes equal to the inner diameter of the lumen, and the proximal end of the absorbent body may extend closer to the proximal end than the distal end of the ground surface.
- the absorber in the bodily fluid collecting device according to the second aspect, is inserted into the lumen so as to be movable along the longitudinal axis. It may be attached to.
- the distal end portion of the absorber When the operation member is moved to the distal end side with respect to the long shaft member, the distal end portion of the absorber may be disposed closer to the distal end side than the long shaft member.
- the identification unit is observable from the outer peripheral surface side of the long shaft member. It may be a pigment of the scabbard provided in the above.
- the absorber may be arranged on the tip side of the dye in the initial state. When a certain amount of the body fluid is absorbed, the outer diameter of the absorber is equal to the inner diameter of the lumen, and the proximal end of the absorber may extend further to the proximal end than the distal end of the area where the dye is provided. Good.
- the identification portion is a side hole formed so as to reach the lumen from the outer peripheral surface of the long shaft member. May be.
- the absorbent body may not block the side hole in the initial state, and the expanded absorbent body may block the side hole when the absorbent body absorbs a certain amount of the body fluid.
- the identification part is a side hole formed so as to reach the lumen from the outer peripheral surface of the long shaft member. May be.
- the absorber may have an outer diameter in the initial state smaller than an inner diameter of the lumen, and may be disposed in the lumen at a radially inner side of the side hole while being separated from the side hole.
- the absorbent body may expand radially outward so that the outer diameter of the absorbent body is equal to the inner diameter of the lumen.
- an outer peripheral surface of the absorber may be in contact with the inner peripheral surface of the lumen over the entire periphery.
- the identification part may be a communication hole formed in the absorber along the longitudinal axis. When the absorber absorbs a certain amount of the body fluid, the inner peripheral surface of the communication hole of the absorber may expand toward the inside in the radial direction by the radius of the communication hole.
- the identification unit includes a pair of electrodes provided on the inner peripheral surface of the lumen so as to face each other, and a pair A light generation unit, a sound generation unit, or a vibration generation unit that are connected to the electrodes and operate when a closed circuit is formed together with the pair of electrodes.
- the absorber may have an outer diameter in the initial state equal to or less than a distance between the pair of electrodes. In the initial state, the absorber may not be disposed between the pair of electrodes. When the absorber absorbs a certain amount of the body fluid, the expanded absorber is disposed between the pair of electrodes, and the outer diameter of the absorber increases more than the distance between the pair of electrodes. Also good.
- the absorber can be easily collected in a state in which the absorber absorbs a certain amount of body fluid.
- a bodily fluid collection device (hereinafter also abbreviated as “device”) according to a first embodiment of the present invention will be described with reference to FIGS.
- the device 1 of the present embodiment absorbs a body fluid and a flexible sheath (long axis member) 10 having a lumen (through hole) 11 formed along a longitudinal axis C1. And the frosted glass (identification part) 20 for identifying that the absorbent body 15 has absorbed a certain amount of body fluid.
- the sheath 10 is formed in a cylindrical shape.
- the sheath 10 is provided with a locking portion 13 protruding from the inner peripheral surface of the lumen 11 inward in the radial direction of the sheath 10 over the entire periphery of the sheath 10.
- the locking part 13 is formed with a through hole 13a that is substantially circular when viewed in the direction along the longitudinal axis C1.
- the sheath 10 is made of a resin such as PTFE (polytetrafluoroethylene) and has a certain strength with respect to a tensile force along the longitudinal axis C1 and a force to spread outward in the radial direction.
- a protective film 14 that closes the opening at the tip of the lumen 11 is attached to the sheath 10.
- the protective film 14 can be formed of, for example, a porous film of PTFE resin. As will be described later, the protective film 14 is set to a thickness that prevents body fluid from entering the lumen 11 and can be broken by pressing with the absorber 15.
- the ground glass 20 is provided at a position closer to the distal end side than the locking portion 13 in the sheath 10 and in the vicinity of the locking portion 13 so as to penetrate from the inner peripheral surface of the sheath 10 to the outer peripheral surface. That is, the ground glass 20 is provided in the sheath 10 so that observation is possible from the outer peripheral surface side.
- the ground glass 20 may be provided over the entire circumference of the sheath 10 or may be provided in a part of the circumferential direction of the sheath 10.
- the frosted glass 20 is provided on the distal end side by a predetermined length from the locking portion 13. In the frosted glass 20, a ground surface 21 having fine irregularities formed on the inner peripheral surface side of the sheath 10 is formed.
- the ground surface 21 looks opaque by scattering light (visible light).
- the outer peripheral surface of the frosted glass 20 is a mirror surface 22 formed flatter than the ground surface 21.
- the inner peripheral surface and the outer peripheral surface of the ground glass 20 and the sheath 10 on the distal end side of the ground glass 20 are flush with each other.
- the ground glass 20 and the locking portion 13 are arranged side by side with no gap in the direction along the longitudinal axis C1.
- the absorber 15 is formed in a cylindrical shape with polyvinyl acetate or the like. In the initial state where the body fluid is not absorbed, the outer diameter of the absorbent body 15 is equal to or smaller than the inner diameter L1 of the lumen 11.
- the distal end surface 15a of the absorber 15 is formed in a curved shape that is convex toward the distal end side. In the absorber 15, even when the body fluid is absorbed from a part of the absorber 15, the body fluid spreads throughout the absorber 15 due to capillary action. The absorber 15 expands as it absorbs body fluid from the initial state. In this example, the absorber 15 of the device 1 before use is arranged in the lumen 11.
- the absorber 15 is attached to the distal end portion of the support bar 16 by inserting a support bar (operation member) 16 extending along the longitudinal axis C1 from the base end side.
- the outer diameter of the support bar 16 is smaller than the inner diameter of the through hole 13 a of the locking portion 13.
- the tip of the support bar 16 is fixed inside the absorber 15.
- a locked portion 17 that protrudes radially outward is provided over the entire circumferential direction of the sheath 10 on the proximal end side of the support rod 16 relative to the locking portion 13.
- the outer diameter of the locked portion 17 is smaller than the aforementioned inner diameter L1 and larger than the inner diameter of the through hole 13a.
- the support rod 16 and the locked portion 17 are integrally formed of a metal having biocompatibility such as stainless steel.
- the support bar 16 is inserted into the lumen 11 of the sheath 10 so as to be movable along the longitudinal axis C1.
- a cylindrical handle 18 is fixed to the base end of the support bar 16.
- the outer diameter of the handle 18 is smaller than the inner diameter L1.
- the locked portion 17 of the support bar 16 is disposed away from the locking portion 13 toward the proximal end side.
- the distance between the locking portion 13 and the locked portion 17 is such that the absorbent body 15 delivers a certain amount of bodily fluid in a state in which the supporting rod 16 is pushed in and the locked portion 17 is locked in the locking portion 13. It is set so that the base end portion of the absorber 15 is disposed in the lumen 11 when absorbed.
- the device 1 configured in this way is used in combination with a known endoscope 200 shown in FIG.
- the endoscope 200 is a so-called direct-view type endoscope, and has an elongated insertion portion 210, an operation portion 230 provided at a proximal end portion of the insertion portion 210, and one end portion attached to a side surface of the operation portion 230.
- the insertion portion 210 has a distal end rigid portion 211 provided at the distal end, a bending portion 212 that is attached to the proximal end portion of the distal end rigid portion 211 and can be bent, and is attached to the proximal end portion of the bending portion 212 to provide flexibility.
- the flexible tube portion 213 is provided.
- a light guide 216 formed of a bundle of optical fibers and an observation unit 217 having an objective lens and a CCD (Charge Coupled Device) are provided on the distal end surface 211a of the distal rigid portion 211 in an exposed state. Yes.
- the light guide 216 passes through the insertion portion 210 and the operation portion 230 and extends to the universal cable 240.
- the objective lens forms an image of the observation object in front of the hard tip portion 211 on the light receiving surface of the CCD.
- the CCD converts an image to be observed into a signal representing an image, and transmits the converted signal to the signal wiring 218.
- the signal wiring 218 passes through the insertion portion 210 and the operation portion 230 and extends to the universal cable 240.
- An opening communicating with the channel 219 is formed in the distal end surface 211 a of the distal end hard portion 211. The proximal end side of the channel 219 extends to the operation unit 230 through the flexible tube portion 213.
- a plurality of bending pieces are connected in the longitudinal direction of the insertion portion 210.
- the distal end portion of the operation wire is attached to the bending piece on the most distal end side.
- the proximal end side of the operation wire extends to the operation unit 230 through the flexible tube unit 213.
- the operation unit 230 is provided with a knob 231 for pulling back and pushing the operation wire, and a switch 232 for operating an opening / closing valve (not shown) provided in the operation unit 230.
- a knob 2331 for pulling back and pushing the operation wire
- a switch 232 for operating an opening / closing valve (not shown) provided in the operation unit 230.
- the knob 231 By operating the knob 231, the bending portion 212 can be bent in a desired direction by operating the operation wire.
- An insertion port 233 communicating with the channel 219 is provided on the distal end side of the operation unit 230.
- a forceps plug 234 is attached to the insertion port 233.
- the distal end portion of the suction pipe 236 communicates with the channel 219.
- the proximal end side of the suction conduit 236 extends into the universal cable 240.
- An integrated connector 241 is provided on the base end side of the universal cable 240.
- a light source device 244 and a monitor 245 are attached to the integrated connector 241.
- the light source device 244 supplies illumination light emitted from a built-in lamp (not shown) to the base end surface of the light guide 216.
- the monitor 245 includes a signal processing circuit (not shown). A signal transmitted through the signal wiring 218 is converted by a signal processing circuit, and an image to be observed acquired by the CCD is displayed on the display panel 245a of the monitor 245.
- the suction device 246 is connected to the connector 241a provided in the integrated connector 241.
- the suction device 246 includes a pump 246a that performs a suction operation.
- the suction device 246 connected to the connector 241a can suck the inside of the channel 219 through the suction line 236 by operating the pump 246a when the above-described on-off valve is in an open state.
- duodenal fluid body fluid
- the duodenal juice mentioned here means not only the narrowly defined duodenal juice secreted from the duodenum but also pancreatic juice and bile.
- a user such as an operator irradiates illumination light emitted from the light source device 244 in front of the insertion portion 210 via the light guide 216.
- the insertion part 210 of the endoscope 200 is inserted into the patient's body through a natural opening such as the mouth, and the insertion part 210 is advanced to the duodenum P2 near the duodenal papilla P1 as shown in FIG.
- the bending unit 212 is appropriately bent by operating the knob 231 as necessary while observing an image displayed on the display panel 245a of the monitor 245. Further, by operating the switch 232 to suck the inside of the channel 219, a physiological saline (not shown) that has washed the inside of the duodenum P2 is sucked out of the body.
- the sheath 10 of the device 1 is inserted into the channel 219 through the forceps plug 234 from the distal end side.
- the distal end portion of the sheath 10 is protruded from the channel 219.
- the support bar 16 is moved to the distal end side via the handle 18 with respect to the sheath 10 (pushing), and the locked portion 17 is locked to the base end side surface of the locking portion 13.
- the distal end portion of the absorbent body 15 is disposed on the distal end side rather than the sheath 10, and the protective film 14 is broken by being pushed by the absorbent body 15.
- the proximal end portion of the absorbent body 15 is disposed on the distal end side with respect to the ground surface 21 of the ground glass 20 in the lumen 11.
- the absorber 15 is not in contact with the ground surface 21.
- the amount by which the sheath 10 protrudes from the channel 219 is adjusted so that the ground glass 20 enters the visual field range R1 corresponding to the image acquired by the CCD of the observation unit 217.
- the absorber 15 is brought into contact with the duodenal fluid P3 in the duodenum P2 by operating the knob 231 to bend the bending portion 212 or the like. Since the distal end portion of the absorbent body 15 is arranged on the distal end side rather than the sheath 10, the absorbent body 15 can be easily brought into contact with the duodenal juice P3.
- the duodenal fluid P3 is absorbed by the absorber 15. The user observes the image of the frosted glass 20 with the monitor 245 while holding the state where the locked portion 17 is locked to the locking portion 13 and the absorber 15 is positioned with respect to the sheath 10. As shown in FIG.
- the absorbent body 15 expands from the original shape S by absorbing the duodenal fluid P3 and increases in outer diameter and extends toward the proximal end side.
- the outer diameter on the proximal end side of the absorbent body 15 becomes equal to the inner diameter L1 of the lumen 11, and the proximal end of the absorbent body 15 is closer to the proximal end side than the distal end of the grinding surface 21. It contacts the stretch locking part 13.
- the certain amount mentioned here means, for example, from about 50 ⁇ L (microliter. 10 ⁇ 9 m 3 ) to about 53 ⁇ L.
- the base end portion of the absorbent body 15 contacts the grinding surface 21.
- the duodenal juice P3 absorbed by the absorber 15 adheres to the ground surface 21, the effect of scattering light due to moisture contained in the duodenal juice P3 is weakened, and the color of the ground glass 20 becomes transparent from an opaque state. It changes to approach.
- the proximal end portion of the absorbent body 15 that has absorbed the duodenal juice P3 comes into contact with the locking portion 13, the duodenal juice P3 is further absorbed from the state in which the duodenal fluid P3 is absorbed until the absorbent body 15 contacts the ground glass 20. Is reliably prevented.
- the user moves the device 1 to the proximal side with respect to the forceps plug 234 (retracts), and pulls the device 1 from the channel 219 of the endoscope 200. Unplug.
- the proximal end portion of the absorber 15 that has absorbed the duodenal fluid P3 is disposed in the lumen 11, so that the proximal end portion of the absorber 15 that has absorbed a certain amount of duodenal fluid P3 is covered with the sheath 219.
- the device 1 is pulled out from.
- the insertion portion 210 of the endoscope 200 is pulled out from the patient's mouth.
- the device 1 that has absorbed a certain amount of duodenal juice P3 removes the absorber 15 from the device 1 and extracts the duodenal juice P3 absorbed by the absorber 15 in the diluted solution.
- the concentration of a specific tumor marker in the pancreatic juice extracted in the diluted solution is measured, and pancreatic cancer is examined.
- the absorbent body 15 is disposed in the lumen 11 when absorbing the duodenal fluid P3, the proximal end portion of the absorbent body 15 that expands.
- the side surface of the has a constant shape.
- the absorber 15 can absorb a certain amount of duodenal juice P3 accurately.
- the frosted glass 20 serving as the identification unit is provided, a change in the color of the frosted glass 20 in contact with the absorber 15 that has absorbed the duodenal juice P3 is observed with the endoscope 200, whereby the absorber 15 has a certain amount of duodenal juice. The user can easily identify that P3 has been absorbed.
- the proximal end portion of the absorbent body 15 that has absorbed the duodenal fluid P3 is disposed in the lumen 11, so that the proximal end portion of the absorbent body 15 that has absorbed the duodenal fluid P3 is in contact with the inner peripheral surface of the channel 219 and the like.
- the absorber 15 can be easily recovered in a state where the absorber 15 absorbs a certain amount of duodenal juice P3.
- the position of the absorber 15 with respect to the sheath 10 can be adjusted.
- the absorbent body 15 is pushed by the support rod 16, the distal end portion of the absorbent body 15 is arranged on the distal end side rather than the sheath 10, so that the absorbent body 15 can be easily brought into contact with the duodenal juice P3. it can.
- the absorbent body 15 when the absorbent body 15 absorbs a certain amount of duodenal juice P3, the distal end portion of the absorbent body 15 protrudes from the sheath 10, and only the proximal end portion of the absorbent body 15 is disposed in the lumen 11. He said. However, when the locked portion 17 is locked to the locking portion 13 with respect to the absorbent body 15 in the initial state, and when the absorbent body 15 absorbs a certain amount of duodenal fluid P3, the entire absorbent body 15 is It may be arranged in the lumen 11.
- the entire absorbent body 15 in the initial state is disposed in the lumen 11, the duodenal fluid P3 that has entered the lumen 11 through the opening on the distal end side can be absorbed by the absorbent body 15.
- the entire absorbent body 15 that has absorbed a certain amount of duodenal fluid P3 is disposed in the lumen 11, the entire absorbent body 15 can be prevented from coming into contact with the inner peripheral surface of the channel 219, and recovery can be performed. It becomes easier.
- the device 1 of this embodiment can be variously modified in its configuration as described below.
- the stepped portion 26 may be formed on the proximal end side of the sheath 10 by expanding the diameter of the proximal end side.
- the inner diameter of the lumen 11 on the tip side of the step portion 26 is smaller than the outer diameter of the handle 18.
- the locking portion 13 and the locked portion 17 are not provided in the device 1A.
- FIG. 6 in the device 1 ⁇ / b> A configured as described above, when the handle 18 is pushed into the sheath 10, the handle 18 is locked to the step portion 26 of the sheath 10. Even if the device 1A is configured in this way, the position along the longitudinal axis C1 of the absorbent body 15 with respect to the sheath 10 can be positioned.
- the color change part 31 contains the pigment
- the dye 31b is purple when not in contact with the duodenal juice P3.
- the dye 31b can be observed by the observation unit 217 of the endoscope 200 from the outer peripheral surface side of the sheath 10 when the plate glass 31a transmits illumination light.
- the outer diameter of the absorber 15 in the initial state is smaller than the inner diameter L1 of the lumen 11.
- the outer diameter of the absorber 15 that has expanded by absorbing the duodenal fluid P3 is the inner diameter of the lumen 11, as shown in FIG. It becomes equal to L1, and the proximal end of the absorber 15 extends to the proximal end side from the distal end of the range where the dye 31b is provided.
- the proximal end portion of the absorber 15 comes into contact with the pigment 31b, the color of the pigment 31b changes from purple to colorless by reacting with moisture contained in the duodenal juice P3.
- a user who observes this color change with the endoscope 200 can identify that the absorber 15 has absorbed a certain amount of duodenal juice P3.
- the entire absorbent body 15 is positioned within the distal end portion of the lumen 11, it is possible to prevent the absorbent body 15 that has absorbed the duodenal fluid P3 from contacting the inner peripheral surface of the channel 219 or the like.
- the absorber 15 can be recovered more easily.
- the entire color changing portion may be configured by solidifying the color of the scabbard by known means.
- a side hole 36 formed so as to reach the lumen 11 from the outer peripheral surface of the sheath 10 may be provided instead of the ground glass 20 as an identification portion.
- the surface 36a on the base end side of the side hole 36 is separated from the longitudinal axis C1 toward the base end side. It is preferable to be inclined.
- One side hole 36 may be formed in the sheath 10, or a plurality of side holes 36 may be formed apart from each other around the longitudinal axis C1.
- the absorber 15 in the initial state when the locked portion 17 is locked and positioned by the locking portion 13 is disposed at a position where the side hole 36 is not blocked. Specifically, the absorber 15 is disposed on the distal end side with respect to the side hole 36, more specifically, on the distal end side with respect to the range R2 in the sheath 10 that can be observed through the side hole 36 in the visual field range R1. The absorber 15 cannot be observed from the observation unit 217 of the endoscope 200 through the side hole 36 by being blocked by the wall portion of the sheath 10.
- the absorber 15 of the device 1C configured as described above absorbs a certain amount of duodenal juice P3, the absorber 15 that expands and extends to the proximal end side closes the side hole 36 as shown in FIG.
- the absorber 15 can be observed through the side hole 36 by the observation unit 217. Also with the device 1C of this modification, the same effects as those of the device 1 of the present embodiment can be obtained.
- the device 2 of the present embodiment has the aforementioned side hole 36 instead of the locking portion 13, the support bar 16, the locked portion 17, and the handle 18 of the device 1 of the first embodiment.
- a plurality of side holes 36 are formed in the sheath 10 so as to be spaced apart from each other in the direction along the longitudinal axis C1.
- a plurality of side holes 36 are also formed in the radial direction of the sheath 10.
- the absorbent body 15 in the initial state is positioned so that the entirety of the absorbent body 15 is positioned in the distal end portion of the lumen 11, and is supported by the sheath 10 by a support member (not shown).
- the absorber 15 has an initial outer diameter smaller than the inner diameter L1 of the lumen 11.
- the absorber 15 is disposed in the lumen 11 so as to be separated from the side hole 36 and radially inward of the side hole 36. That is, a gap T is formed between the inner peripheral surface of the lumen 11 and the absorber 15 over the entire circumference of the absorber 15.
- the absorber 15 in the initial state does not completely block the lumen 11.
- the absorbent body 15 in the initial state forms a gap T between the lumen 11 and does not block the side holes 36.
- the device 2 configured in this manner is used in combination with the endoscope 200 as described above.
- the sheath 10 is inserted into the channel 219 through the forceps plug 234.
- a syringe body W1 of a known syringe W which is a suction mechanism, is airtightly attached to the sheath 10 at the proximal end portion of the sheath 10 of the device 2.
- the distal end portion of the sheath 10 is projected from the channel 219, and the sheath 10 is inserted into the duodenum P2 (not shown).
- the syringe W is gripped and the plunger W2 is pulled back with respect to the syringe body W1.
- the lumen 11 has a negative pressure lower than that in the duodenum P2, and the body gas and the duodenal fluid P3 are drawn into the lumen 11 through the gap T and the side hole 36 of the lumen 11.
- the absorber 15 expands radially outward as shown in FIG. 12, and when the duodenal fluid P3 is absorbed by a certain amount, the outer diameter of the absorber 15 is equal to the inner diameter L1 of the lumen 11. Become. Thereby, the expanded absorbent body 15 closes the opening and the side hole 36 on the distal end side of the lumen 11.
- the absorbent body 15 can be easily recovered in a state where the absorbent body 15 has absorbed a certain amount of duodenal juice P3.
- the user since it is not necessary to observe on the monitor 245 that the absorber 15 has absorbed a certain amount of the duodenal juice P3, the user can perform observation on the part other than the absorber 15 with the monitor 245.
- the plurality of side holes 36 are formed in the sheath 10, but only one side hole 36 may be formed in the sheath 10.
- the device 3 of this embodiment includes an absorber 41 in place of the absorber 15 and the plurality of side holes 36 of the device 2 of the second embodiment.
- the absorber 41 is formed in a cylindrical shape.
- the outer peripheral surface of the absorber 41 is in contact with the inner peripheral surface of the lumen 11 over the entire periphery.
- a communication hole (identification part) 41a having a radius L2 is formed along the longitudinal axis C1.
- the absorber 41 can be formed of the same material as the absorber 15 described above.
- the syringe body W1 When using the device 3 configured as described above, the syringe body W1 is attached to the proximal end portion of the sheath 10, and the sheath 10 is inserted into the duodenum P2.
- the plunger W2 When the plunger W2 is pulled back, the gas in the body is drawn into the lumen 11 through the communication hole 41a of the absorber 41.
- the absorber 41 expands as it absorbs the duodenal fluid P3, whereby the inner peripheral surface of the communication hole 41a expands radially inward over the entire circumference as shown in FIG.
- the absorber 41 absorbs a certain amount of duodenal juice P3, the inner peripheral surface of the communication hole 41a expands by a radius L2 from the initial state.
- the communication hole 41a is blocked and it becomes difficult to draw gas into the lumen 11 through the communication hole 41a.
- the user recognizes that the absorber 41 has absorbed a certain amount of duodenal juice P3 by making it difficult for the plunger W2 to be pulled back.
- the same effects as those of the device 2 of the second embodiment can be obtained.
- the device 4 of this embodiment includes an identification unit 46 instead of the locking part 13, the locked part 17, and the handle 18 of the device 1 of the first embodiment.
- the identification unit 46 includes a pair of electrodes 47 and 48 provided on the inner peripheral surface of the lumen 11 and a light generation unit 49 connected to the pair of electrodes 47 and 48, respectively.
- the electrodes 47 and 48 are attached to the inner peripheral surface of the lumen 11 via the insulating member 53.
- the electrodes 47 and 48 are arranged so as to face each other.
- the light generation unit 49 includes a wiring 50 whose ends are connected to the electrodes 47 and 48, a DC power supply 55 such as a battery provided in series with the wiring 50, and a warning lamp 56.
- the wiring 50 is obtained by coating a conductive electric wire with an insulating covering material. In the wiring 50, the electric wire is exposed from the covering material at each end, and the electric wire is electrically connected to the electrodes 47 and 48.
- the DC power supply 55 and the warning lamp 56 are of a known configuration and are electrically connected to the wires of the wiring 50.
- the outer diameter L4 of the absorber 15 in the initial state is equal to or less than the distance L5 between the pair of electrodes 47 and 48. In the initial state, the absorber 15 is not disposed between the electrodes 47 and 48.
- the warning lamp 56 is disposed near the user when the sheath 10 of the device 4 is inserted through the forceps plug 234.
- the absorber 15 expands to increase the outer diameter and to extend to the proximal end side.
- the proximal end portion is disposed between the electrodes 47 and 48 as shown in FIG. 16, and the outer diameter increases to the distance L5 or more. Thereby, the expanded absorbent body 15 comes into contact with the pair of electrodes 47 and 48, respectively.
- the absorber 15 Since the absorber 15 has conductivity by absorbing the duodenal fluid P3 containing moisture, the electrode 47 and the electrode 48 are electrically connected via the absorber 15. A closed circuit is formed by the electrodes 47 and 48, the light generator 49, and the absorber 15, and a current flows through the wiring 50 by the DC power supply 55.
- the warning light 56 emits light that alerts the user, and the user identifies that the absorber 15 has absorbed a certain amount of duodenal juice P3.
- the absorbent body 15 can be easily recovered in a state where the absorbent body 15 has absorbed a certain amount of duodenal juice P3. Even when the visual field of the observation unit 217 is poor, for example, when a body fluid adheres to a portion exposed to the outside in the observation unit 217, the light emitted from the warning lamp 56 reliably indicates that the absorber 15 has absorbed a certain amount of duodenal fluid P3. Can be identified.
- the identification unit 46 includes the light generation unit 49 that emits light.
- the identification unit may include a sound generation unit including a speaker that generates sound instead of the light generation unit 49, or may include a vibration generation unit including a vibrator that generates vibration.
- the user can identify that the absorber 15 has absorbed a certain amount of duodenal juice P3 with a sense other than vision.
- the electrodes 47 and 48 may be directly attached to the inner peripheral surface of the lumen 11 without the insulating member 53 interposed therebetween.
- the absorber 15 may be disposed between the electrodes 47 and 48.
- the outer diameter L4 of the absorber 15 is smaller than the distance L5 between the electrodes 47 and 48, the absorber 15 is configured not to contact the electrodes 47 and 48 simultaneously.
- the body fluid is the duodenal fluid P3.
- the body fluid is not limited to this and may be, for example, pancreatic juice or bile.
- the entire absorbent body 15 is located in the lumen 11 before absorbing the duodenal juice P3 and after absorbing a certain amount of duodenal juice P3. It may be. By comprising in this way, the shape of the absorber 15 after absorbing and expanding the duodenal juice P3 can be further stabilized, and the accuracy of the amount of absorbing the duodenal juice P3 can be increased.
- the device is used in combination with the direct-view type endoscope 200 has been described, these devices may be used in combination with a so-called side-view type endoscope.
- the absorber can be easily recovered in a state where a certain amount of body fluid is absorbed by the absorber.
Abstract
Description
本願は、2013年11月6日に出願された日本国特願2013-230309号に基づき優先権を主張し、その内容をここに援用する。
以下、本発明の第1実施形態に係る体液採取用デバイス(以下、「デバイス」とも略称する。)を、図1から図10を参照しながら説明する。
次に、本発明の第2実施形態について図11および図12を参照しながら説明する。前記実施形態と同一の部位には同一の符号を付してその説明は省略し、異なる点についてのみ説明する。
次に、本発明の第3実施形態について図13および図14を参照しながら説明する。前記実施形態と同一の部位には同一の符号を付してその説明は省略し、異なる点についてのみ説明する。
次に、本発明の第4実施形態について図15および図16を参照しながら説明する。前記実施形態と同一の部位には同一の符号を付してその説明は省略し、異なる点についてのみ説明する。
10 シース(長軸部材)
11 ルーメン
15、41 吸収体
16 支持棒(操作部材)
20 すりガラス(識別部)
21 すり加工面
31b 色素(識別部)
36 側孔
41a 連通孔(識別部)
46 識別部
47、48 電極
49 光発生部
C1 長手軸
P3 十二指腸液(体液)
Claims (8)
- 長手軸に沿ってルーメンが形成された長軸部材と、
体液を吸収していない初期状態から前記体液を吸収するのにしたがって膨張するとともに、前記体液を一定量吸収したときに基端部が前記ルーメン内に配される吸収体と、
前記吸収体が前記体液を一定量吸収したことを識別するための識別部と、
を備える体液採取用デバイス。 - 前記識別部は、前記長軸部材に外周面側から観察可能に設けられ、前記長軸部材の内周面側がすり加工面とされたすりガラスであり、
前記吸収体は、前記初期状態のときに外径が前記ルーメンの内径以下であり前記すり加工面よりも先端側に配され、
前記体液を一定量吸収したときに、前記吸収体の外径は前記ルーメンの内径に等しくなり、前記吸収体の基端は前記すり加工面の先端よりも基端側に伸びる
請求項1に記載の体液採取用デバイス。 - 前記吸収体は、前記ルーメン内に前記長手軸に沿って移動可能に挿通された操作部材の先端部に取付けられ、
前記長軸部材に対して前記操作部材を先端側に移動させたときには、前記長軸部材よりも前記吸収体の先端部の方が先端側に配置される
請求項2に記載の体液採取用デバイス。 - 前記識別部は、前記長軸部材の外周面側から観察可能に前記長軸部材の内周面側に設けられたオオボウシバナの色素であり、
前記吸収体は、前記初期状態のときに前記色素よりも先端側に配され、
前記体液を一定量吸収したときに、前記吸収体の外径は前記ルーメンの内径に等しくなり、前記吸収体の基端は前記色素が設けられた範囲の先端よりも基端側に伸びる
請求項1に記載の体液採取用デバイス。 - 前記識別部は、前記長軸部材の外周面から前記ルーメンに達するように形成された側孔であり、
前記吸収体は、前記初期状態では前記側孔を塞がず、
前記吸収体が前記体液を一定量吸収したときに、膨張した前記吸収体が前記側孔を塞ぐ
請求項1に記載の体液採取用デバイス。 - 前記識別部は、前記長軸部材の外周面から前記ルーメンに達するように形成された側孔であり、
前記吸収体は、前記初期状態における外径が前記ルーメンの内径よりも小さく、前記ルーメン内に前記側孔から離間して前記側孔の径方向内側に配置され、
前記吸収体が前記体液を一定量吸収したときに、前記吸収体が径方向外側に向かって膨張し前記吸収体の外径が前記ルーメンの内径に等しくなる
請求項1に記載の体液採取用デバイス。 - 前記吸収体は、外周面が前記ルーメンの内周面に全周にわたり接触し、
前記識別部は、前記吸収体に前記長手軸に沿って形成された連通孔であり、
前記吸収体が前記体液を一定量吸収したときに、前記吸収体の前記連通孔の内周面が径方向内側に向かって前記連通孔の半径だけ膨張する
請求項1に記載の体液採取用デバイス。 - 前記識別部は、
前記ルーメンの内周面に互いに対向するように設けられた一対の電極と、
一対の前記電極にそれぞれ接続され、一対の前記電極とともに閉回路が形成されたときに動作する光発生部、音発生部または振動発生部と、
を有し、
前記吸収体は、前記初期状態における外径が一対の前記電極間の距離以下であり、
前記初期状態では、前記吸収体は一対の前記電極間に配置されていなく、
前記吸収体が前記体液を一定量吸収したときに、膨張した前記吸収体は一対の前記電極間に配置されるとともに、前記吸収体の外径が一対の前記電極間の距離以上に増加する
請求項1に記載の体液採取用デバイス。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201480043843.8A CN105451665A (zh) | 2013-11-06 | 2014-10-22 | 体液提取用装置 |
JP2015522301A JP5840329B2 (ja) | 2013-11-06 | 2014-10-22 | 体液採取用デバイス |
EP14860520.7A EP3066986A4 (en) | 2013-11-06 | 2014-10-22 | Body-fluid sampling device |
US15/055,093 US20160174948A1 (en) | 2013-11-06 | 2016-02-26 | Body fluid collection device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013-230309 | 2013-11-06 | ||
JP2013230309 | 2013-11-06 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/055,093 Continuation US20160174948A1 (en) | 2013-11-06 | 2016-02-26 | Body fluid collection device |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2015068575A1 true WO2015068575A1 (ja) | 2015-05-14 |
Family
ID=53041357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2014/078085 WO2015068575A1 (ja) | 2013-11-06 | 2014-10-22 | 体液採取用デバイス |
Country Status (5)
Country | Link |
---|---|
US (1) | US20160174948A1 (ja) |
EP (1) | EP3066986A4 (ja) |
JP (1) | JP5840329B2 (ja) |
CN (1) | CN105451665A (ja) |
WO (1) | WO2015068575A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10912539B2 (en) * | 2017-02-07 | 2021-02-09 | New York University | Endoswab for sampling and culture in minimally invasive surgery |
EP3578110A1 (en) * | 2018-06-07 | 2019-12-11 | Nokia Technologies Oy | Method and apparatus for sampling and imaging |
CN111481236B (zh) * | 2020-04-15 | 2023-02-28 | 杭州憶盛医疗科技有限公司 | 一种内科用消化道液体活检取样装置 |
CN115137652B (zh) * | 2022-08-29 | 2022-11-04 | 吉林大学 | 一种肠液收集回输装置 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001137248A (ja) | 1999-11-16 | 2001-05-22 | Olympus Optical Co Ltd | サンプル採取具 |
JP2006528907A (ja) * | 2003-05-23 | 2006-12-28 | セノークス・インコーポレイテッド | 繊維質マーカー及びその体内送達 |
WO2011096515A1 (ja) * | 2010-02-05 | 2011-08-11 | オリンパス株式会社 | 検査器具 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5065768A (en) * | 1988-09-13 | 1991-11-19 | Safe-Tec Clinical Products, Inc. | Self-sealing fluid conduit and collection device |
US4946440A (en) * | 1988-10-05 | 1990-08-07 | Hall John E | Evertible membrane catheter and method of use |
US5283038A (en) * | 1990-12-18 | 1994-02-01 | Saliva Diagnostic Systems, Inc. | Fluid sampling and testing device |
CN1164182A (zh) * | 1994-11-21 | 1997-11-05 | 伯纳德·查菲林恩 | 将药液输入体腔的专用装置 |
US7374723B2 (en) * | 2002-07-31 | 2008-05-20 | Dräger Safety AG & Co. KGaA | System for collecting and releasing saliva |
US7618591B2 (en) * | 2004-01-28 | 2009-11-17 | Bamburgh Marrsh Llc | Specimen sample collection device and test system |
KR100865834B1 (ko) * | 2004-10-05 | 2008-10-28 | 올림푸스 가부시키가이샤 | 내시경 시스템 및 생체 시료 수용 용기 |
AU2008242921A1 (en) * | 2007-04-16 | 2008-10-30 | Orasure Technologies, Inc. | Sample collector |
-
2014
- 2014-10-22 EP EP14860520.7A patent/EP3066986A4/en not_active Withdrawn
- 2014-10-22 CN CN201480043843.8A patent/CN105451665A/zh active Pending
- 2014-10-22 JP JP2015522301A patent/JP5840329B2/ja active Active
- 2014-10-22 WO PCT/JP2014/078085 patent/WO2015068575A1/ja active Application Filing
-
2016
- 2016-02-26 US US15/055,093 patent/US20160174948A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001137248A (ja) | 1999-11-16 | 2001-05-22 | Olympus Optical Co Ltd | サンプル採取具 |
JP2006528907A (ja) * | 2003-05-23 | 2006-12-28 | セノークス・インコーポレイテッド | 繊維質マーカー及びその体内送達 |
WO2011096515A1 (ja) * | 2010-02-05 | 2011-08-11 | オリンパス株式会社 | 検査器具 |
Non-Patent Citations (1)
Title |
---|
See also references of EP3066986A4 |
Also Published As
Publication number | Publication date |
---|---|
US20160174948A1 (en) | 2016-06-23 |
JP5840329B2 (ja) | 2016-01-06 |
CN105451665A (zh) | 2016-03-30 |
EP3066986A4 (en) | 2017-08-02 |
EP3066986A1 (en) | 2016-09-14 |
JPWO2015068575A1 (ja) | 2017-03-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5840329B2 (ja) | 体液採取用デバイス | |
US20140187999A1 (en) | Apparatus, system and method for providing image-guided in-vivo biopsy with at least one capsule | |
JPH11276422A (ja) | 超音波内視鏡 | |
JPH08117232A (ja) | 穿刺具 | |
US9713461B2 (en) | Body fluid collection device and endoscope system | |
EP1935363A2 (en) | Organ anastomosis marker, marker positioning apparatus and transendoscopic gastrojejunal anastomosis procedure | |
JP5836505B2 (ja) | 内視鏡用アダプタ及び内視鏡 | |
JP2010094367A (ja) | 内視鏡用アダプタ | |
CN110353737A (zh) | 顺应性无创伤护套顶端 | |
EP3644824A1 (en) | A rigid endoscope | |
JP5989277B2 (ja) | 内視鏡の先端構造 | |
JP5572781B1 (ja) | 超音波プローブシステム | |
US20160029880A1 (en) | Cystoscopic device and methods for operating same | |
RU109399U1 (ru) | Устройство для трансторакальной пункции патологической полости | |
JP3691625B2 (ja) | 磁気共鳴観測装置 | |
CN211486135U (zh) | 一种可视导引鞘 | |
KR101633736B1 (ko) | 내시경 | |
CN216417119U (zh) | 一种适用于软性内窥镜的附件递送装置 | |
JP2023541093A (ja) | カテーテル及び係るカテーテルを含むカテーテルキット | |
CN110559545A (zh) | 一种可视导引鞘 | |
CN117794437A (zh) | 具有松散式光导体的活检装置 | |
CN114521862A (zh) | 一种新型组合式超细支气管镜 | |
JP2004159771A (ja) | 超音波内視鏡の穿刺針ユニット | |
CN117729874A (zh) | 具有照明引导和安全特征的套管针和气腹型针 | |
WO2019004840A1 (en) | RIGID ENDOSCOPE |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 201480043843.8 Country of ref document: CN |
|
ENP | Entry into the national phase |
Ref document number: 2015522301 Country of ref document: JP Kind code of ref document: A |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 14860520 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
REEP | Request for entry into the european phase |
Ref document number: 2014860520 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2014860520 Country of ref document: EP |