WO2015064153A1 - 不活性ガス充填用ノズル、不活性ガス充填装置、及び輸液入り容器の製造方法 - Google Patents
不活性ガス充填用ノズル、不活性ガス充填装置、及び輸液入り容器の製造方法 Download PDFInfo
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- WO2015064153A1 WO2015064153A1 PCT/JP2014/067899 JP2014067899W WO2015064153A1 WO 2015064153 A1 WO2015064153 A1 WO 2015064153A1 JP 2014067899 W JP2014067899 W JP 2014067899W WO 2015064153 A1 WO2015064153 A1 WO 2015064153A1
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- gas
- infusion
- filling
- inert gas
- port
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1406—Septums, pierceable membranes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65B31/04—Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied
- B65B31/041—Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied the nozzles acting from above on containers or wrappers open at their top
- B65B31/042—Evacuating, pressurising or gasifying filled containers or wrappers by means of nozzles through which air or other gas, e.g. an inert gas, is withdrawn or supplied the nozzles acting from above on containers or wrappers open at their top the nozzles being arranged for insertion into, and withdrawal from, the container or wrapper
Definitions
- the present invention relates to an inert gas filling nozzle for performing inert gas replacement in an infusion container, an inert gas filling apparatus including the nozzle, and a method for manufacturing an infusion container using the nozzle.
- the present invention prevents a defective seal from occurring due to liquid droplets adhering to the seal portion of the container due to the scattering of the infusion liquid after the infusion container is filled with an inert gas through the filling port of the container. It is an object of the present invention to provide an inert gas filling nozzle, an inert gas filling device, and a method for producing an infusion-containing container using the nozzle.
- the inert gas filling nozzle according to the first aspect of the present invention has a filling port formed therein, and an infusion container having a seal portion where a seal for closing the filling port is applied, before the sealing.
- a nozzle for filling an inert gas for preventing deterioration of the infusion solution through the filling port comprising a cylindrical nozzle body.
- the nozzle body has a tip portion and a middle portion, and is inserted into the infusion container from the tip portion side via the filling port.
- the middle portion is spaced a predetermined distance from the tip portion so that the nozzle body comes close to the seal site when the nozzle body is inserted into the infusion container from the tip side through the filling port.
- a gas first outlet is formed at the tip.
- a second gas outlet is formed in the middle portion.
- a nozzle for filling an infusion container with an inert gas for preventing deterioration of the infusion has a cylindrical nozzle body, and a gas outlet (first outlet) is formed at the tip of the nozzle body.
- a gas ejection port (second ejection port) is also formed in the middle portion of the nozzle body located at a predetermined interval from the tip. Further, the middle gas outlet is located in the vicinity of the sealing portion of the infusion container to be sealed later to close the filling port when the nozzle body is inserted into the infusion container through the filling port. come. That is, according to this nozzle, gas is ejected in the vicinity of the seal portion.
- the infusion liquid scatters in the infusion container due to the gas squirted from the first ejection port at the tip of the nozzle body, the scattered liquid droplets are ejected from the second ejection port in the middle of the nozzle body.
- the gas prevents or remains attached to the seal site. Therefore, after filling the infusion container with an inert gas through the filling port of the container, it is possible to prevent a sealing failure from occurring due to the droplets adhering to the seal portion of the container due to the scattering of the infusion liquid. .
- the inert gas filling nozzle according to the second aspect of the present invention is the inert gas filling nozzle according to the first aspect, and the first ejection port is formed on a side surface of the tip portion.
- the 1st jet nozzle is formed in the side surface of the front-end
- An inert gas filling nozzle is the inert gas filling nozzle according to the first aspect or the second aspect, wherein the second ejection port is formed on a side surface of the middle part.
- the shape of the slit is the shape of the slit.
- the second outlet in the middle of the nozzle body is slit-shaped. Therefore, the gas can be sprayed uniformly on the seal portion with a simple configuration, and the infusion liquid droplets are prevented from adhering to the entire seal portion.
- An inert gas filling nozzle is the inert gas filling nozzle according to any one of the first to third aspects, wherein the nozzle body communicates with the first ejection port. And a second gas channel communicating with the second jet port. The second gas channel is separated from the first gas channel.
- gas is supplied from different gas flow paths to the first jet port and the second jet port. Therefore, the gas jetting operation from the first jet port and the second jet port can be controlled independently. For example, the flow rate, pressure, gas ejection timing, and gas type at the time of gas ejection may be different between the first ejection port and the second ejection port.
- An inert gas filling device includes the inert gas filling nozzle according to any one of the first to fourth aspects and an ejection control unit.
- the ejection control unit controls an operation of ejecting gas from the first ejection port and the second ejection port.
- the same effect as the first aspect can be achieved.
- An inert gas filling device is the inert gas filling device according to the fifth aspect, in which the ejection control unit is configured to simultaneously supply gas from the first ejection port and the second ejection port. Control to spout.
- An inert gas filling device is the inert gas filling device according to the fifth aspect or the sixth aspect, wherein the ejection control unit is configured to supply gas ejected from the first ejection port.
- the first flow rate and the second flow rate of the gas ejected from the second ejection port are independently controlled.
- gases having different flow rates can be ejected from the first ejection port and the second ejection port. That is, the flow rate of the gas ejected through the first ejection port and the second ejection port can be appropriately controlled according to each purpose.
- the ejection through the first ejection port is mainly intended to supply an inert gas into the infusion container
- the ejection through the second ejection port is mainly a liquid droplet on the seal portion of the infusion container. It is intended to prevent the adhesion of.
- the method for producing an infusion-containing container according to the eighth aspect of the present invention is a method for producing an infusion-containing container using the inert gas filling nozzle according to any one of the first to fourth aspects, wherein the infusion A step of filling the container with the infusion solution, a step of inserting the nozzle body into the infusion container from the tip end side through the filling port, and a state in which the nozzle body is inserted into the infusion container. , A step of performing inert gas replacement in the infusion container by simultaneously jetting gas from the first jet port and the second jet port, and a step of sealing the seal portion after the inert gas replacement With.
- the same effect as the first aspect can be achieved.
- the gas when an inert gas for preventing deterioration of the infusion solution is filled in the infusion container, the gas is ejected in the vicinity of the seal portion.
- the infusion liquid scatters in the infusion container due to the gas squirted from the first ejection port at the tip of the nozzle body, the scattered liquid droplets are ejected from the second ejection port in the middle of the nozzle body.
- the gas prevents or remains attached to the seal site. Therefore, after filling the infusion container with an inert gas through the filling port of the container, it is possible to prevent a sealing failure from occurring due to the droplets adhering to the seal portion of the container due to the scattering of the infusion liquid. .
- IV-IV sectional drawing of FIG. The figure which shows the insertion state by which the gas supply nozzle is inserted in the infusion bag.
- FIG. 1 shows a gas supply nozzle 10 which is an inert gas filling nozzle and an infusion bag manufacturing apparatus 1 which is an inert gas filling device according to this embodiment.
- the infusion bag manufacturing apparatus 1 fills the infusion bag 8 shown in FIG. 2A with an infusion solution together with an inert gas (typically nitrogen), and then closes the filling port S1 of the infusion bag 8.
- an inert gas typically nitrogen
- part shown with an oblique line in FIG. 2 is a site
- the gas supply nozzle 10 is attached to the infusion bag manufacturing apparatus 1 and used for filling with an inert gas.
- the infusion bag 8 targeted in this embodiment is a bag-shaped container formed from a sheet made of a soft resin such as polyethylene, polypropylene, polyvinyl chloride or the like. More specifically, as shown in FIGS. 2A and 2B, the infusion bag 8 is heat-sealed on the outer edge portion 82 of these sheets 80 after the two rectangular sheets 80 are stacked. It shape
- a seal portion 81 that defines the filling port S1 in the upper center of the infusion bag 8 is heat-sealed in a state before filling with the infusion solution shown in FIG.
- heat sealing is performed as shown in FIG.
- the infusion bag 8 is a bag having an internal space S2 and a filling port S1 communicating with the internal space S2 before filling with the infusion solution.
- the infusion solution and the inert solution into the internal space S2 through the filling port S1. Gas filling is performed.
- the “vertical direction” is defined as shown in FIGS. 2 and 3 unless otherwise specified.
- the infusion in the infusion bag 8 does not come into contact with air (particularly oxygen), and deterioration due to oxidation or the like is prevented.
- the infusion in this embodiment contains components such as amino acids, fats, proteins, and vitamins, and is relatively easily foamed by gas blowing. In other embodiments, the infusion contains other components. It may be.
- the configuration of the nozzle 10 will be described in detail. Moreover, the process in which the infusion bag 8 with an infusion is manufactured by the infusion bag manufacturing apparatus 1 is also demonstrated in detail.
- the infusion bag manufacturing apparatus 1 includes a gas supply nozzle 10, a liquid supply nozzle 20, a controller 30, a first gas cylinder 41, a second gas cylinder 42, a first gas pipe 51, and a second gas pipe 52. , Liquid tank 21, liquid pipe 22, first valve 61, second valve 62, third valve 63, bag gripping part 70, heat sealer 71, first lifting mechanism 73, and second lifting mechanism 74.
- grip part 70, the heat sealer 71, the 1st raising / lowering mechanism 73, and the 2nd raising / lowering mechanism 74 are connected to the controller 30, and each of these parts is All the operations are controlled by the controller 30.
- the gas supply nozzle 10 has a double-pipe structure as will be described later.
- the first gas cylinder 41 and the second gas cylinder 42 are connected to two gas flow paths in the gas supply nozzle 10 through a first gas pipe 51 and a second gas pipe 52, respectively.
- the first valve 61 and the second valve 62 are provided in the middle of the first gas pipe 51 and the second gas pipe 52, respectively, and adjust the flow rate of the gas flowing in the first gas pipe 51 and the second gas pipe 52. can do.
- the liquid supply nozzle 20 is used to fill the infusion solution into the infusion bag 8.
- the liquid tank 21 is connected to a liquid flow path in the liquid supply nozzle 20 via a liquid pipe 22.
- the third valve 63 is provided in the middle of the liquid pipe 22 and can adjust the flow rate of the infusion flowing through the liquid pipe 22.
- the bag gripping portion 70 is a mechanism for supporting the bag 70 during the infusion into the infusion bag 8 and the filling operation of the inert gas.
- the first elevating mechanism 73 and the second elevating mechanism 74 are mechanisms that elevate and lower the gas supply nozzle 10 and the liquid supply nozzle 20 with respect to the filling port S1 of the infusion bag 8 held by the bag holding portion 70, respectively.
- the first elevating mechanism 73 and the second elevating mechanism 74 are, for example, a guide rail that extends in the vertical direction, a slider that slides in the guide rail, and a power source such as a motor that moves the slider along the guide rail. Can be realized. In this case, the gas supply nozzle 10 and the liquid supply nozzle 20 are fixed to the slider.
- the heat sealer 71 has a pair of heat blocks that sandwich and heat-seal the two seal portions 81 in a state where the infusion bag 8 is separated.
- the heat block is heated to a temperature at which the seal part 81 can be thermally welded.
- the gas supply nozzle 10 is a nozzle for injecting an inert gas into the infusion bag 8 to perform inert gas replacement after the infusion bag 8 is filled with the infusion solution.
- the gas supply nozzle 10 is inserted into the infusion bag 8 from the lower end portion 12b side through the filling port S1 of the infusion bag 8 at the time of inert gas replacement.
- FIG. 3 is a side view of the gas supply nozzle 10, and for the sake of explanation, the internal shape is partially shown by dotted lines.
- 4 is a cross-sectional view taken along the line IV-IV in FIG.
- the gas supply nozzle 10 has a cylindrical nozzle body 11 having a double tube structure, and has two flow paths for supplying gas into the infusion bag 8. It prescribes.
- the nozzle body 11 includes a cylindrical inner wall portion 12 and a cylindrical outer wall portion 13 that is disposed outside the inner wall portion 12 with a predetermined distance from the inner wall portion 12.
- the inner space S ⁇ b> 3 (first gas flow path) surrounded by the inner surface of the inner wall portion 12, and the outer space S ⁇ b> 4 surrounded by the outer surface of the inner wall portion 12 and the inner surface of the outer wall portion 13. (Second gas flow path) is formed.
- the cross section of the inner wall part 12 and the outer wall part 13 is circular shape in this embodiment, However, At least one of the inner wall part 12 and the outer wall part 13 may be made into other shapes, such as a rectangle. it can.
- the inner space S ⁇ b> 3 communicates with the first gas pipe 51 at the upper end 12 a of the inner wall portion 12, and gas is supplied from the first gas cylinder 41 through the first gas pipe 51.
- the outer space S ⁇ b> 4 communicates with the second gas pipe 52 at the upper end portion 13 a of the outer wall portion 13, and gas is supplied from the second gas cylinder 42 via the second gas pipe 52.
- the lower end part 13b (middle part) of the outer wall part 13 is located above the lower end part 12b (tip part) of the inner wall part 12 with a certain distance L1.
- this interval L ⁇ b> 1 is the state in which the nozzle body 11 is inserted into the infusion bag 8 from the lower end portion 12 b side through the filling port S ⁇ b> 1 of the infusion bag 8 (hereinafter referred to as an insertion state).
- 13 is designed so that the lower end 13b of 13 is in the vicinity of the sealing part 81 of the infusion bag 8 (substantially the same position in the vertical direction).
- the inserted state is a state in which the first valve 61 and the second valve 62 are opened, and the inert gas is supplied from the first gas cylinder 41 and the second gas cylinder 42 into the inner space S3 and the outer space S4. It is. Further, the bottom surface portion 14 is continuous with the lower end edge of the lower end portion 12 b of the inner wall portion 12, and the bottom surface portion 15 is also continuous with the lower end edge of the lower end portion 13 b of the outer wall portion 13. That is, the lower end edges of the lower end portions 12b and 13b are both closed.
- a plurality of first ejection ports S5 communicating with the inner space S3 are formed on the side surface of the lower end portion 12b of the inner wall portion 12, and the outer space S4 is also formed on the side surface of the lower end portion 13b of the outer wall portion 13.
- a plurality of second ejection ports S6 that communicate with each other are formed.
- the first ejection ports S ⁇ b> 5 are each circular and all have the same shape, and are arranged at equal intervals along the circumferential direction of the lower end portion 12 b of the inner wall portion 12.
- six first ejection ports S5 are formed, and are therefore arranged at intervals of 60 ° along the circumferential direction.
- each of the second ejection ports S6 has a slit shape, and all have the same shape, and each extends along the circumferential direction of the lower end portion 13b of the outer wall portion 13.
- twelve slits S6 are formed. More specifically, slits S6 occupying a width of 90 ° in the circumferential direction are arranged in three stages in the vertical direction, and four sets of such three slits S6 are arranged at intervals of 90 ° along the circumferential direction. It is arranged.
- the sets of slits S6 adjacent to each other in the circumferential direction are arranged at alternate positions in the vertical direction. Further, the interval between the uppermost slit S6 and the lowermost slit S6 of each set is approximately equal to the height of the seal portion 81 in the vertical direction. Further, in the inserted state, the uppermost slit S6 of each set is disposed in the vicinity of the upper end of the seal portion 81, and the lowermost slit S6 of each set is disposed in the vicinity of the lower end of the seal portion 81.
- the inert gas is strongly ejected downward, that is, toward the liquid level of the infusion. There is no. Accordingly, when the inert gas is filled, infusion of the infusion solution is suppressed in the infusion bag 8 and droplets are prevented from adhering to the inner surface of the seal portion 81.
- the second spout S6 has a slit shape, extends over the entire circumferential direction as a whole, and extends over the entire height direction of the seal portion 81 in the vertical direction. Gas is blown without.
- the inert gas ejected from the first ejection port S5 and the second ejection port S6 is sealed. Since the sprayed liquid is sprayed on the entire inner surface of 81, it is possible to prevent the scattered liquid droplets from adhering to or remaining attached to the inner surface of the seal portion 81. Therefore, when heat sealing is performed on the sealing portion 81 after filling with the inert gas, it is possible to prevent a sealing failure from occurring.
- the infusion bag 8 in the state of FIG. 2 (A) is formed by an upstream device and conveyed to the infusion bag manufacturing device 1.
- the infusion bag 8 is gripped by the bag gripping portion 70 with the filling port S1 facing upward, and is set at a filling position below the liquid supply nozzle 20 and the gas supply nozzle 10.
- the liquid supply nozzle 20 is lowered by the second lifting mechanism 74 and inserted into the filling port S1 of the infusion bag 8. Then, the controller 30 opens the third valve 63, and the infusion solution 8 is filled from the solution tank 21 through the solution pipe 22. When the filling of the predetermined amount of infusion is completed, the controller 30 closes the third valve 63.
- the liquid supply nozzle 20 is raised by the second lifting mechanism 74, and then the gas supply nozzle 10 is lowered by the first lifting mechanism 73 and inserted into the filling port S1 of the infusion bag 8 (see FIG. 5).
- the first valve 61 and the second valve 62 are opened by the controller 30.
- the inert gas is sent from the first gas cylinder 41 and the second gas cylinder 42 to the inner space S3 and the outer space S4 in the gas supply nozzle 10 through the first gas pipe 51 and the second gas pipe 52, respectively.
- an inert gas is ejected from the first ejection port S5 and the second ejection port S6 in the lateral direction.
- the controller 30 adjusts the opening degree of the first valve 61 and the second valve 62 independently, thereby allowing the first flow rate P1 and the second jet port S6 of the gas ejected from the first jet port S5.
- the second flow rate P2 of the ejected gas is controlled independently.
- the first flow rate P1 and the second flow rate P2 are control parameters that are appropriately set according to various conditions such as the volume of the infusion bag 8, the filling amount of the infusion solution, and the filling amount of the inert gas, and the manufacture of the infusion bag 8 is started. It has been set in advance. Note that controlling the first flow rate P1 and the second flow rate P2 is equivalent to controlling the pressure of the gas ejected from the first ejection port S5 and the second ejection port S6.
- the controller 30 closes the first valve 61 and the second valve 62.
- the controller 30 simultaneously opens the first valve 61 and the second valve 62 and simultaneously closes the first valve 61 and the second valve 62.
- the timing for opening the first valve 61 and the second valve 62 be at least partially simultaneous, that is, overlap, but not to overlap. You may control.
- the gas supply nozzle 10 is raised by the first elevating mechanism 73, and then the heat sealer 71 sandwiches the seal portion 81 of the infusion bag 8 from both sides. As a result, heat sealing is performed on the sealing portion 81, and the filling port S1 is closed. Thereafter, the completed infusion bag 8 is delivered to a downstream device by the bag gripping portion 70. And the controller 30 repeats the above operation
- the gas supply nozzle 10 for filling the infusion bag 8 with the inert gas for preventing deterioration of infusion is provided.
- the nozzle 10 has a cylindrical nozzle body 11, and a gas outlet (first outlet S ⁇ b> 5) is formed at the lower end 12 b of the inner wall portion 12 of the nozzle body 11.
- a gas ejection port (second ejection port S6) is also formed in the lower end portion 13b of the outer wall portion 13 that is located at a predetermined distance L1 from the lower end portion 12b in the nozzle body 11.
- the second spout S6 is a sealing portion of the infusion bag 8 that is sealed later to close the filling port S1 when the nozzle body 11 is inserted into the infusion bag 8 through the filling port S1.
- Near 81 That is, according to the nozzle 10, gas is ejected in the vicinity of the seal portion 81.
- the scattered droplets adhere to the seal part 81 by the gas ejected from the second ejection port S6. To prevent or remain attached.
- the sealing failure may occur due to the droplets adhering to the seal portion 81 of the bag 8 due to scattering of the infusion solution. Can be prevented.
- a bag-type infusion container (infusion bag 8) is manufactured.
- the present invention is not limited to other types, for example, a bottle-type infusion container as long as it has a seal portion that is sealed after filling with an inert gas. Can also be used in the manufacture of
- the infusion solution and the gas are filled into the infusion bag 8 through the same filling port S1 of the infusion bag 8.
- the filling port S1 is exclusively used for gas filling, and the infusion filling is performed separately from the filling port S1.
- the present invention can also be applied to an infusion container in which a filling port is formed.
- the two sealing portions 81 of the infusion bag 8 are sealed so as to be in direct contact with each other, but the port member is sandwiched between the two sealing portions 81 so that the sealing portion 81 and the port You may make it seal a member.
- the infusion bag manufacturing apparatus 1 conveys the port member so as to be inserted into the filling port S1 of the infusion bag 8 before filling with the heat sealer 71 after filling with the infusion solution and the inert gas. It is preferable to further have a mechanism.
- the port member is inserted into the filling port S1 of the infusion bag 8, seals the infusion bag 8 when the infusion bag 8 is not used, and is connected to another connector or a member such as a syringe when used.
- a member such as a syringe when used.
- it is a member that allows fluid communication between the inside and outside of the infusion bag 8 through these members.
- the method of sealing the filling port S1 is not limited to heat sealing (thermal welding), and can be changed to other methods as long as the sealing portion 81 is sealed, such as ultrasonic sealing.
- the number, arrangement, and shape of the first ejection ports S5 are not limited to those described above, and can be changed as appropriate.
- the number of the first outlets S5 may be one or a plurality other than six.
- the shape of the first ejection port S5 is not limited to a circular shape, and may be an arbitrary shape such as an elliptical shape, a rectangular shape, or a slit shape.
- the number, arrangement, and shape of the second ejection ports S6 are not limited to those described above, and can be changed as appropriate.
- the number of second ejection ports S6 may be one or a plurality other than twelve.
- the shape of the second ejection port S6 is not limited to the slit shape, and may be an arbitrary shape such as a circular shape, an elliptical shape, a rectangular shape, etc., in the same manner as the aspect described above with respect to the first ejection port S5.
- the bottom surface portion 14 may be omitted from the lower end portion 12b, or a gas spout is formed on the bottom surface portion 14.
- A first ejection port
- gas is ejected downward from the lower end portion 12b of the inner wall portion 12 toward the liquid level of the infusion solution, but droplets adhere to the seal portion 81 by the gas ejected from the second ejection port S6. It is possible to prevent the sealing failure.
- the bottom surface portion 15 may be omitted from the lower end portion 13b, or the bottom surface A gas outlet (second outlet) may be formed in the portion 15. That is, in this case, the gas is ejected downward from the lower end portion 13b of the outer wall portion 13 toward the liquid surface, but the gas is ejected from the second ejection port S6 on the side surface of the lower end portion 13b to the liquid at the seal portion 81. It is possible to prevent droplets from adhering and to prevent poor sealing.
- Infusion bag manufacturing equipment infusion bag (inert gas filling equipment) 8 Infusion bag (infusion container) 81 Sealing part 10
- Gas supply nozzle infusion nozzle
- Nozzle body 12b Lower end (front end) of inner wall 13b Lower end (outer part) of outer wall 30
- Controller jet control unit
- S1 filling port S3 inner space (first gas flow path)
- S4 Outer space (second gas flow path)
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Abstract
Description
ここでは、第1噴出口及び第2噴出口から異なる流量のガスを噴出することができる。すなわち、第1噴出口及び第2噴出口を介して噴出されるガスの流量を、それぞれの目的に応じて適宜制御することができる。なお、第1噴出口を介しての噴出は、主として不活性ガスを輸液容器内に供給することを目的とし、第2噴出口を介しての噴出は、主として輸液容器のシール部位への液滴の付着を防止することを目的としている。
図1に、本実施形態に係る不活性ガス充填用ノズルであるガス供給ノズル10及び不活性ガス充填装置である輸液バッグ製造装置1を示す。輸液バッグ製造装置1は、図2(A)に示す輸液バッグ8内に輸液とともに不活性ガス(典型的には、窒素)を充填し、その後、輸液バッグ8の充填口S1を閉じることで、図2(B)に示す輸液入りの輸液バッグ8を製造するための装置である。なお、図2において斜線で示される部位は、ヒートシールが施されている部位である。ガス供給ノズル10は、輸液バッグ製造装置1に装着され、不活性ガスの充填に用いられる。
図1に示すように、輸液バッグ製造装置1は、ガス供給ノズル10の他、液供給ノズル20、コントローラ30、第1ガスボンベ41、第2ガスボンベ42、第1ガス配管51、第2ガス配管52、液タンク21、液配管22、第1弁61、第2弁62、第3弁63、バッグ把持部70、ヒートシーラ71、第1昇降機構73及び第2昇降機構74を備える。なお、第1弁61、第2弁62、第3弁63、バッグ把持部70、ヒートシーラ71、第1昇降機構73及び第2昇降機構74は、コントローラ30に接続されており、これらの各部の動作は、全てコントローラ30により制御される。
以下、ガス供給ノズル10の詳細な構成について説明する。ガス供給ノズル10は、輸液バッグ8内に輸液が充填された後、不活性ガス置換を行うべく輸液バッグ8内に不活性ガスを注入するためのノズルである。ガス供給ノズル10は、不活性ガス置換時に、その下方の先端部12b側から輸液バッグ8の充填口S1を介して輸液バッグ8内に挿入される。
以下、輸液バッグ製造装置1により輸液入りの輸液バッグ8が製造される工程について詳細に説明する。
上記実施形態では、輸液の劣化を防止するための不活性ガスを輸液バッグ8内に充填するためのガス供給ノズル10が提供される。このノズル10は、筒状のノズル本体11を有し、ノズル本体11の内壁部12の下端部12bには、ガスの噴出口(第1噴出口S5)が形成されている。また、ノズル本体11において下端部12bから所定の間隔L1を空けて位置する外壁部13の下端部13bにも、ガスの噴出口(第2噴出口S6)が形成されている。さらに、この第2噴出口S6は、ノズル本体11が輸液バッグ8内に充填口S1を介して挿入されたときに、充填口S1を閉じるために後にシールが施される輸液バッグ8のシール部位81の近傍にくる。すなわち、このノズル10によれば、シール部位81の近傍においてガスの噴出が行われる。その結果、第1噴出口S5から噴出されるガスにより輸液バッグ8内において輸液が飛散したとしても、当該飛散した液滴が、第2噴出口S6から噴出されるガスにより、シール部位81に付着する又は付着したままになることが防止される。従って、輸液バッグ8内に当該バッグ8の充填口S1を介して不活性ガスを充填した後、輸液の飛散により当該バッグ8のシール部位81に付着した液滴のせいでシール不良が生じることを防止することができる。
以上、本発明の一実施形態について説明したが、本発明は上記実施形態に限定されるものではなく、その趣旨を逸脱しない限りにおいて、種々の変更が可能である。例えば、以下の変更が可能である。さらに、以下の変形例の要旨は、適宜組み合わせることが可能である。
上記実施形態では、バッグタイプの輸液容器(輸液バッグ8)が製造されたが、本発明は、不活性ガスの充填後にシールされるシール部位を有する限り、その他のタイプ、例えば、ボトルタイプの輸液容器の製造にも使用することができる。
上記実施形態では、輸液及びガスが輸液バッグ8の同じ充填口S1を介して輸液バッグ8内に充填されたが、充填口S1がガスの充填専用とされ、充填口S1とは別に輸液の充填用の充填口が形成されている輸液容器に対しても、本発明を適用することができる。
上記実施形態では、輸液バック8の2枚の対面するシール部位81が直接接触するようにシールされたが、これらの2枚のシール部位81の間に、ポート部材を挟み込み、シール部位81とポート部材とをシールするようにしてもよい。この場合、輸液バッグ製造装置1は、輸液及び不活性ガスの充填後、ヒートシーラ71によるシールを行う前に、輸液バック8の充填口S1内に挿入されるようにポート部材を搬送してくる搬送機構をさらに有することが好ましい。なお、ポート部材とは、輸液バック8の充填口S1に挿入され、輸液バック8の非使用時において輸液バック8を密封するとともに、使用時においては別のコネクタやシリンジ等の部材に接続されることで、これらの部材を介して輸液バック8の内外を液体連通させる部材である。
充填口S1をシールする方法は、ヒートシール(熱溶着)に限られず、例えば、超音波シール等、シール部位81がシールされる限り、他の方法に変更することができる。
第1噴出口S5の数、配置及び形状は、上述したものに限られず、適宜変更可能である。例えば、第1噴出口S5の数は、1つであってもよいし、6つ以外の複数個であってもよい。また、第1噴出口S5が複数個形成される場合において、これらの噴出口S5が全て内壁部12の下端部12bの周方向に沿って等間隔で配置される必要はないし、及び/又は、上下方向に異なる位置に配置されてもよい。また、第1噴出口S5の形状も円形状に限られず、楕円形状、矩形状、スリット状等の任意の形状とすることができる。
内壁部12の下端部12bの側面に第1噴出口S5を形成することに代えて又は加えて、下端部12bから底面部14を省略してもよいし、又は底面部14にガスの噴出口(第1噴出口)を形成してもよい。すなわち、この場合、内壁部12の下端部12bから輸液の液面に向かって下方にガスが噴出されるが、第2噴出口S6から噴出されるガスにより、シール部位81に液滴が付着することが防止され、シール不良を防止することが可能である。
8 輸液バッグ(輸液容器)
81 シール部位
10 ガス供給ノズル(不活性ガス充填用ノズル)
11 ノズル本体
12b 内壁部の下端部(先端部)
13b 外壁部の下端部(中部)
30 コントローラ(噴出制御部)
L1 内壁部の下端部と外壁部の下端部との間隔(先端部と中部との間隔)
S1 充填口
S3 内側空間(第1ガス流路)
S4 外側空間(第2ガス流路)
S5 第1噴出口
S6 第2噴出口
Claims (8)
- 充填口が形成されているとともに、前記充填口を閉じるためのシールが施されるシール部位を有する輸液容器内に、前記シール前に前記充填口を介して輸液の劣化を防止するための不活性ガスを充填するためのノズルであって、
先端部及び中部を有し、前記先端部側から前記充填口を介して前記輸液容器内に挿入される筒状のノズル本体、
を備え、
前記中部は、前記ノズル本体が前記先端部側から前記充填口を介して前記輸液容器内に挿入されたときに、前記シール部位の近傍にくるように、前記先端部から所定の間隔を空けて配置されており、
前記先端部には、ガスの第1噴出口が形成されており、
前記中部には、ガスの第2噴出口が形成されている、
不活性ガス充填用ノズル。 - 前記第1噴出口は、前記先端部の側面に形成されている、
請求項1に記載の不活性ガス充填用ノズル。 - 前記第2噴出口は、前記中部の側面に形成されており、スリットの形状である、
請求項1又は2に記載の不活性ガス充填用ノズル。 - 前記ノズル本体は、前記第1噴出口に連通する第1ガス流路、及び、前記第1ガス流路と分離され、前記第2噴出口に連通する第2ガス流路を有する、
請求項1から3のいずれかに記載の不活性ガス充填用ノズル。 - 請求項4に記載の不活性ガス充填用ノズルと、
前記第1噴出口及び前記第2噴出口からガスを噴出する動作を制御する噴出制御部と
を備える、
不活性ガス充填装置。 - 前記噴出制御部は、前記第1噴出口及び前記第2噴出口からガスが同時に噴出するように制御する、
請求項5に記載の不活性ガス充填装置。 - 前記噴出制御部は、前記第1噴出口から噴出されるガスの第1流量及び前記第2噴出口から噴出されるガスの第2流量を独立して制御する、
請求項5又は6に記載の不活性ガス充填装置。 - 請求項1から4のいずれかに記載の不活性ガス充填用ノズルを用いて輸液入り容器を製造する方法であって、
前記輸液容器内に前記輸液を充填するステップと、
前記ノズル本体を前記先端部側から前記充填口を介して前記輸液容器内に挿入するステップと、
前記輸液容器内に前記ノズル本体が挿入された状態で、前記第1噴出口及び前記第2噴出口からガスを同時に噴出させることにより、前記輸液容器内で不活性ガス置換を行うステップと、
前記不活性ガス置換後、前記シール部位にシールを施すステップと
を備える、
輸液入り容器の製造方法。
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CN111107822A (zh) * | 2017-09-22 | 2020-05-05 | 费森尤斯卡比德国有限公司 | 填充医疗包装的方法、填充设备和构造成囊袋的医疗包装 |
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CN110813469B (zh) * | 2019-10-24 | 2023-09-22 | 广东邦泽创科电器股份有限公司 | 一种具有压纸功能的碎纸机 |
KR102326775B1 (ko) * | 2020-03-10 | 2021-11-17 | 농업회사법인 한백식품(주) | 질소 가스 충전용 노즐 |
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