WO2015055277A1 - Method for producing polyclonal antibodies using an antigenic composition comprising protein-containing membrane vesicles - Google Patents
Method for producing polyclonal antibodies using an antigenic composition comprising protein-containing membrane vesicles Download PDFInfo
- Publication number
- WO2015055277A1 WO2015055277A1 PCT/EP2014/002592 EP2014002592W WO2015055277A1 WO 2015055277 A1 WO2015055277 A1 WO 2015055277A1 EP 2014002592 W EP2014002592 W EP 2014002592W WO 2015055277 A1 WO2015055277 A1 WO 2015055277A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- target protein
- membrane vesicles
- vesicles
- host
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6018—Lipids, e.g. in lipopeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Insects & Arthropods (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201480055072.4A CN105612178B (zh) | 2013-10-15 | 2014-09-24 | 利用包含含蛋白膜囊泡的抗原组合物制备多克隆抗体的方法 |
US15/027,775 US10308716B2 (en) | 2013-10-15 | 2014-09-24 | Method for producing polyclonal antibodies using an antigenic composition comprising protein-containing membrane vesicles |
KR1020167009586A KR102356689B1 (ko) | 2013-10-15 | 2014-09-24 | 단백질 함유 막소포를 포함하는 항원조성을 이용하여 다중클론성 항체를 제조하는 방법 |
JP2016523216A JP6625528B2 (ja) | 2013-10-15 | 2014-09-24 | タンパク質含有膜小胞を含む抗原性組成物を使用したポリクローナル抗体を産生するための方法 |
CA2924357A CA2924357C (en) | 2013-10-15 | 2014-09-24 | Method for producing polyclonal antibodies using an antigenic composition comprising protein-containing membrane vesicles |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13004943.0A EP2862874B1 (en) | 2013-10-15 | 2013-10-15 | Method for producing polyclonal antibodies using an antigenic composition comprising protein-containing membrane vesicles |
EP13004943.0 | 2013-10-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2015055277A1 true WO2015055277A1 (en) | 2015-04-23 |
Family
ID=49447902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2014/002592 WO2015055277A1 (en) | 2013-10-15 | 2014-09-24 | Method for producing polyclonal antibodies using an antigenic composition comprising protein-containing membrane vesicles |
Country Status (7)
Country | Link |
---|---|
US (1) | US10308716B2 (und) |
EP (1) | EP2862874B1 (und) |
JP (1) | JP6625528B2 (und) |
KR (1) | KR102356689B1 (und) |
CN (1) | CN105612178B (und) |
CA (1) | CA2924357C (und) |
WO (1) | WO2015055277A1 (und) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000028001A1 (fr) * | 1998-11-05 | 2000-05-18 | Institut National De La Sante Et De La Recherche Medicale | Exosomes modifies et utilisations |
WO2003016522A2 (en) * | 2001-08-17 | 2003-02-27 | Anosys, Inc. | Methods and compounds for the targeting of protein to exosomes |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1433858A1 (en) * | 2002-12-27 | 2004-06-30 | Rengo Co., Ltd. | Preparation method of insect cell extract solution for cell-free protein synthesis, the insect cell extract solution and cell-free synthesis method of protein using the insect cell extract solution |
US20060233789A1 (en) * | 2004-09-24 | 2006-10-19 | Cellfree Science Co., Ltd. | Process for producing antigenic substance |
DE102013020900A1 (de) * | 2013-09-25 | 2015-03-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren und Vorrichtung zur zellfreien Proteinsynthese unter Verwendung eines eukaryotischen Zelllysats in Gegenwart eines Caspase-Inhibitors, sowie Verwendung eines Caspase-Inhibitors zur Steigerung der Ausbeute und/oder der Stabilität der synthetisierten Proteine in einem solchen Verfahren |
-
2013
- 2013-10-15 EP EP13004943.0A patent/EP2862874B1/en active Active
-
2014
- 2014-09-24 JP JP2016523216A patent/JP6625528B2/ja active Active
- 2014-09-24 WO PCT/EP2014/002592 patent/WO2015055277A1/en active Application Filing
- 2014-09-24 CA CA2924357A patent/CA2924357C/en active Active
- 2014-09-24 CN CN201480055072.4A patent/CN105612178B/zh active Active
- 2014-09-24 KR KR1020167009586A patent/KR102356689B1/ko active IP Right Grant
- 2014-09-24 US US15/027,775 patent/US10308716B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000028001A1 (fr) * | 1998-11-05 | 2000-05-18 | Institut National De La Sante Et De La Recherche Medicale | Exosomes modifies et utilisations |
WO2003016522A2 (en) * | 2001-08-17 | 2003-02-27 | Anosys, Inc. | Methods and compounds for the targeting of protein to exosomes |
Non-Patent Citations (4)
Title |
---|
J.S. HAURUM, DRUG DISCOVERY TODAY, vol. 11, no. 13-14, 2006, pages 655 - 660 |
KATZEN ET AL., TRENDS BIOTECHNOL., vol. 23, no. 3, 2005, pages 150 - 156 |
SHAKLEE PAIGE M ET AL: "Protein Incorporation in Giant Lipid Vesicles under Physiological Conditions", CHEMBIOCHEM, vol. 11, no. 2, January 2010 (2010-01-01), pages 175 - 179, XP002720748, ISSN: 1439-4227 * |
STECH MARLITT ET AL: "Cell-free systems: functional modules for synthetic and chemical biology.", ADVANCES IN BIOCHEMICAL ENGINEERING/BIOTECHNOLOGY 2013, vol. 137, 11 April 2013 (2013-04-11), pages 67 - 102, XP009176417, ISSN: 1616-8542 * |
Also Published As
Publication number | Publication date |
---|---|
JP2016533363A (ja) | 2016-10-27 |
CN105612178B (zh) | 2020-01-21 |
CA2924357C (en) | 2022-05-17 |
KR20160062041A (ko) | 2016-06-01 |
JP6625528B2 (ja) | 2019-12-25 |
KR102356689B1 (ko) | 2022-01-27 |
US10308716B2 (en) | 2019-06-04 |
EP2862874A1 (en) | 2015-04-22 |
EP2862874B1 (en) | 2018-12-12 |
CN105612178A (zh) | 2016-05-25 |
US20160251439A1 (en) | 2016-09-01 |
CA2924357A1 (en) | 2015-04-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9506933B2 (en) | Method of preparing antigen for acquiring anti-hydrophobic peptide antibody | |
CN101830983A (zh) | 特异序列基础的水通道蛋白4高效价抗体的制备及应用 | |
KR20030040148A (ko) | 모발성장을 촉진시키는 올리고펩타이드 | |
CN101880316B (zh) | 一种人rbpms多肽及其抗体制备方法 | |
CN1060499A (zh) | 人的透明带蛋白质zp3 | |
CN104861059B (zh) | 一种褐飞虱VgR多肽及其多抗制备方法 | |
CA2924357C (en) | Method for producing polyclonal antibodies using an antigenic composition comprising protein-containing membrane vesicles | |
CN104974245B (zh) | 一种褐飞虱VgR多肽及其多克隆抗体制备方法 | |
CN111363031B (zh) | BNIP3的pSer131多克隆抗体及其制备方法和应用 | |
JP4599527B2 (ja) | 細胞膜タンパク質の立体構造を認識する抗体を産生するハイブリドーマの作製方法 | |
CN108707186B (zh) | 人精子特异性抗原表位肽及其多聚体和应用 | |
CN106589123A (zh) | 一种制备抗高糖基化人绒毛膜促性腺激素抗体的方法 | |
CN101928334A (zh) | 一种鼠Ehf多肽及其抗体制备方法 | |
CN101928333A (zh) | 一种人eif4h多肽及其抗体制备方法 | |
CN113234126A (zh) | 一种多肽以及wnt2多克隆抗体 | |
JPH02264731A (ja) | アイメリア膜結合タンパク質免疫原 | |
US6800462B2 (en) | Production of recombinant proteins in vivo and use for generating antibodies | |
Shojaeian et al. | Heterologous immunization, a way out of the problem of monoclonal antibody production against carcinoma antigen 125 | |
CN101508723A (zh) | 用于制备多克隆抗体的多肽及其应用 | |
LT6770B (lt) | Nilaparvata lugens pce3 polipeptidas ir jam specifinio poliklonino antikūno gamybos būdas | |
KR100477898B1 (ko) | 인간 CacyBP/SIP에 대한 단일클론 항체 및 이를생산하는 융합세포주 | |
CN112501141A (zh) | 一种增加人甲状腺过氧化物酶产量的试剂和表达方法 | |
JP2003210169A (ja) | 抗体及びそれを用いた育毛活性評価方法 | |
JPH08140694A (ja) | ハイブリドーマ | |
CN107281465A (zh) | 一种结核病疫苗候选组分以及含有该组分的疫苗 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 14781061 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2924357 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 15027775 Country of ref document: US |
|
ENP | Entry into the national phase |
Ref document number: 20167009586 Country of ref document: KR Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 2016523216 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 14781061 Country of ref document: EP Kind code of ref document: A1 |