WO2015046922A1 - 치아 미백용 조성물 - Google Patents
치아 미백용 조성물 Download PDFInfo
- Publication number
- WO2015046922A1 WO2015046922A1 PCT/KR2014/008975 KR2014008975W WO2015046922A1 WO 2015046922 A1 WO2015046922 A1 WO 2015046922A1 KR 2014008975 W KR2014008975 W KR 2014008975W WO 2015046922 A1 WO2015046922 A1 WO 2015046922A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- titanium dioxide
- whitening
- peroxide
- tooth
- Prior art date
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 77
- 239000000203 mixture Substances 0.000 title claims abstract description 57
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 119
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 46
- 150000002978 peroxides Chemical class 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 25
- 239000002245 particle Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 14
- -1 perborate Chemical compound 0.000 claims description 4
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 3
- SPAGIJMPHSUYSE-UHFFFAOYSA-N Magnesium peroxide Chemical compound [Mg+2].[O-][O-] SPAGIJMPHSUYSE-UHFFFAOYSA-N 0.000 claims description 2
- 229940078916 carbamide peroxide Drugs 0.000 claims description 2
- 229960004995 magnesium peroxide Drugs 0.000 claims description 2
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 claims description 2
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 claims description 2
- 239000004343 Calcium peroxide Substances 0.000 claims 1
- 229910010413 TiO 2 Inorganic materials 0.000 claims 1
- 235000019402 calcium peroxide Nutrition 0.000 claims 1
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 claims 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-N calcium;phosphoric acid Chemical compound [Ca+2].OP(O)(O)=O.OP(O)(O)=O YYRMJZQKEFZXMX-UHFFFAOYSA-N 0.000 claims 1
- 239000002426 superphosphate Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 description 40
- 230000000052 comparative effect Effects 0.000 description 24
- 238000011156 evaluation Methods 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 238000004061 bleaching Methods 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 230000000007 visual effect Effects 0.000 description 7
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 5
- 239000008151 electrolyte solution Substances 0.000 description 5
- 229940021013 electrolyte solution Drugs 0.000 description 5
- 229960000907 methylthioninium chloride Drugs 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000000354 decomposition reaction Methods 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000011941 photocatalyst Substances 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002086 nanomaterial Substances 0.000 description 3
- 230000002186 photoactivation Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000004381 surface treatment Methods 0.000 description 3
- 239000007852 tooth bleaching agent Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- PQVHMOLNSYFXIJ-UHFFFAOYSA-N 4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]pyrazole-3-carboxylic acid Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(N1CC2=C(CC1)NN=N2)=O)C(=O)O PQVHMOLNSYFXIJ-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical class [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 239000007993 MOPS buffer Substances 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- DQFYEOSNKPKZBH-UHFFFAOYSA-N OO.[O-2].[O-2].[Ti+4] Chemical compound OO.[O-2].[O-2].[Ti+4] DQFYEOSNKPKZBH-UHFFFAOYSA-N 0.000 description 1
- 206010072574 Periodontal inflammation Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 241000950638 Symphysodon discus Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 208000004509 Tooth Discoloration Diseases 0.000 description 1
- 206010044032 Tooth discolouration Diseases 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000020279 black tea Nutrition 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 210000002816 gill Anatomy 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 231100001240 inorganic pollutant Toxicity 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- HOQADATXFBOEGG-UHFFFAOYSA-N isofenphos Chemical compound CCOP(=S)(NC(C)C)OC1=CC=CC=C1C(=O)OC(C)C HOQADATXFBOEGG-UHFFFAOYSA-N 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 229910001947 lithium oxide Inorganic materials 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 125000005342 perphosphate group Chemical group 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 230000036367 tooth discoloration Effects 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
Definitions
- the present invention relates to a composition for whitening teeth. More specifically, the present invention relates to a tooth whitening composition that exhibits an excellent whitening effect.
- Tooth whitening to improve the pigmentation of the teeth self-self-whitening method of home bleaching (office bleaching) by the professional method (office bleaching).
- office bleaching self-self-whitening method of home bleaching (office bleaching) by the professional method (office bleaching).
- the tooth whitening agents used in office bleaching contain relatively high concentrations of hydrogen peroxide and use activation systems such as heat and light to enhance the tooth whitening effect. Heat-using systems may damage the nerves of the teeth, and in recent years, the use of light to enhance the teeth whitening effect is more preferred.
- the photoactivator used in the tooth whitening agent must go through high chemical stability as well as its photocatalyst activity. Because tooth whitening agents contain a very high concentration of peroxide, hydrogen peroxide, if the photoactivator is not chemically stable it will be oxidized first before it can act as a catalyst. Hydrogen peroxide is a material that is known to have strong oxidizing power that can be used industrially to decompose various organic or inorganic pollutants. Compounds with hydroxyl or ketone groups can be readily degraded or oxidized in the presence of hydrogen peroxide. Therefore, organic compounds or complexes containing organic compounds are not suitable as photocatalysts for tooth whitening agents.
- the present invention provides a composition for teeth whitening comprising rutile titanium dioxide, peroxide and water having an average particle diameter of 30 to 180nm.
- rutile titanium dioxide having an average particle diameter of 30 to 180 nm may serve as a photoactivator to provide an excellent tooth whitening effect.
- Figure 2 is a photograph of the teeth comparing the whitening effect before and after applying the tooth whitening composition of Example 3 and Comparative Example 13.
- first and second are used to describe various components, and the terms are used only for the purpose of distinguishing one component from another component.
- each layer or element when each layer or element is referred to as being formed “on” or “on” of each layer or element, it means that each layer or element is formed directly on each layer or element, or It is meant that a layer or element can additionally be formed between each layer, on the object, the substrate.
- the tooth whitening composition of the present invention includes rutile titanium dioxide (Ti (3 ⁇ 4), peroxide, and water having an average particle diameter of 30 to 180 nm.
- Titanium dioxide (Ti0 2 ) is one of the most widely used inorganic photocatalysts worldwide because of its physical and chemical stability, high catalytic activity, low cost, and non-toxicity. It is known that the photoactive mechanism of titanium dioxide is relatively well established and can be used as a tooth whitening agent.
- titanium dioxide shows effective photoactivity only when irradiated with light in the ultraviolet wavelength range. Titanium dioxide has a relatively large energy band gap of 3.2 eV and can be activated in the wavelength range of 300 to 380 nm. Although the effective wavelength limit is reported to be up to 380 nm, the wavelength with the maximum absorbance is actually around 340 nm. In fact, since the wavelength range of the light used in the tooth whitening agent is 380 to 420 nm, the effective wavelength limit needs to be extended to the wavelength range of the visible light of 380 to 420 nm.
- titanium dioxide shows different photoactivity results depending on particle size, crystal phase, surface treatment, shape, and the like.
- Previous studies have found that titanium dioxide in the anatase crystalline form has much greater photoactivity than titanium dioxide in the rutile crystalline form, and smaller particles have a larger surface area when they have the same mass. Particle sized titanium dioxide is known to have greater photoactivity.
- rutile titanium dioxide is the same as anatase. It showed a higher degree of photoactivation than other crystalline or amorphous titanium dioxide, and therefore, it was found that the whitening effect is better when applied to the teeth whitening by light irradiation.
- the smaller the particle size of the titanium dioxide the greater the photoactivity, but the optimum particle size range showing a relatively high photoactivity. '
- the tooth whitening composition of the present invention comprises a rutile titanium dioxide, the average particle diameter of about 30 to about 180nm, or about 50 to about 180nm, even in the rutile titanium dioxide Or titanium dioxide that is about 30 to about 165 nm, or about 50 to 165 nm or about 50 to 100 nm.
- the average particle diameter of the titanium dioxide is too small, i is out of the range or too large, a decrease is also optically active, in particular, titanium dioxide of very small particles may exhibit toxicity. Therefore, when the average particle diameter of titanium dioxide is within the above range, it can exhibit the most effective photoactivation degree without human toxicity.
- the form of the ruyl type titanium dioxide is not particularly limited, but may be a spherical or near-spherical titanium dioxide.
- the said rutile titanium dioxide does not contain another impurity element substantially.
- substantially free of impurity elements means that the rutile titanium dioxide is not mixed with other elements or compounds by a method such as surface treatment, doping, coating, etc., but in the state of titanium dioxide itself. It means to use. Accordingly, the rutile titanium dioxide has a purity of about 97% or more, or about 99% or more, or about 99.9% or more.
- metal elements such as nitrogen (N), silicon (Si), aluminum (A1) or tungsten (W) or aluminum oxides (A1 2 0 3 ), such as aluminum hydroxide ( ⁇ 1 ( ⁇ 3 ))
- impurities such as metal compounds doped, surface treated or coated with titanium dioxide are known to have a better whitening effect, according to the composition for whitening treatment of the present invention, rutile titanium dioxide containing no impurity element Higher photoactivity showed better whitening effect.
- the tooth whitening composition of the present invention when satisfying the conditions of the crystalline form, particle size and purity as described above, compared to the conventional whitening composition for tooth whitening It shows an excellent whitening effect and does not require additional doping or surface treatment on titanium dioxide, which has the additional effect of reducing the production cost.
- That the rutile titanium dioxide is preferably from about 0.01 to about 5 parts by weight 0/0, based on the total composition it may comprise from about 0.01 to about 1% increase. When the content of the titanium dioxide is in the above range can exhibit an appropriate whitening effect without side effects on the human body.
- the tooth whitening composition of the present invention contains a peroxide.
- the peroxide is ionized in an aqueous solution to generate free radicals to decompose the pigment material that causes tooth discoloration.
- a material commonly used for whitening teeth in the art may be used.
- hydrogen peroxide, perborate, percarbonate, perphosphate, persulfates, calper peroxide, magnesium peroxide, carbamide peroxide, and the like, and hydrogen peroxide may be preferably used.
- the peroxide is compared to the range of about 3 to about 45 parts by weight 0/0, or from about 3 to about 35 weight 0/0, or may contain from about 3 to about 15 weight percent, home bleaching, based on the total composition, office
- the tooth whitening composition used for bleaching may contain a high concentration of hydrogen peroxide within the above range. When the content of the peroxide is in the above range can exhibit an appropriate whitening effect without side effects such as etching of teeth. '
- the tooth whitening composition may include water, and may be in an aqueous state containing the titanium dioxide and the peroxide.
- the water content may be included in the amount of the balance remaining except for titanium dioxide, peroxide and other additives.
- the tooth whitening composition of the present invention may further comprise an electrolyte solution.
- the whitening effect can be further enhanced.
- concentration of the electrolyte solution is preferably more than 0 mM to about 7 mM or less, or about 2 mM to about 6 mM, and the content is preferably included in 0.01 to lmg per 1 ml of the composition for tooth whitening.
- Electrolyte solutions that may be included include phosphate buffer, Tris buffer, trisine buffer, or mops buffer (MOPS buffer) and the like, but is not limited thereto, and any biologically widely used electrolyte solution can be used without limitation.
- phosphate buffer Tris buffer, trisine buffer, or mops buffer (MOPS buffer) and the like, but is not limited thereto, and any biologically widely used electrolyte solution can be used without limitation.
- MOPS buffer mops buffer
- composition for whitening teeth of the present invention may further include additives such as gelling agents, pH adjusting agents, stabilizers, moisturizers, chelating agents, surfactants, sweeteners, flavoring agents and the like as needed.
- additives such as gelling agents, pH adjusting agents, stabilizers, moisturizers, chelating agents, surfactants, sweeteners, flavoring agents and the like as needed.
- the additives may be used in materials and contents commonly used in the art to which the present invention pertains, and are not particularly limited.
- the tooth whitening method using the composition for tooth whitening of the present invention can be performed, for example, as follows.
- the tooth whitening composition of the present invention is evenly applied to the surface of the tooth.
- the application of the composition for tooth whitening can be carried out by a method such as applying directly to the tooth or applying the composition for tooth whitening to the substrate in advance or applying it to the tooth and the like, and is not particularly limited.
- light having a wavelength of about 380 to about 420 nm, preferably about 380 to about 405 nm is irradiated to the tooth bleach composition applied to the surface of the tooth.
- the composition for tooth whitening of the present invention includes titanium dioxide of rutile type, thus exhibiting photoactivity in the visible wavelength range as well as opposing bleaching, and home bleaching in which ultraviolet light is difficult to use. It can also be used for ching.
- the kind of light source which irradiates light containing the said wavelength is not specifically limited, For example, a light emitting diode (LED), a fluorescent lamp, an incandescent lamp, etc. can be used.
- LED light emitting diode
- fluorescent lamp fluorescent lamp
- incandescent lamp etc.
- the irradiation time of the light may be determined depending on the type and intensity of the light source, the color of the tooth to be bleached and the degree of the color to be revolved. can do. It is also possible to repeatedly apply the composition for tooth whitening of the present invention one or more times within the irradiation time for a more effective whitening effect. After light irradiation, wash the applied composition by washing.
- the operation and effects of the invention will be described in more detail with reference to specific embodiments of the invention. However, these embodiments are only presented as an example of the invention, whereby the scope of the invention is not determined. ⁇ Example>
- Titanium dioxide-containing colloidal solution was prepared in the same manner as in Preparation Example ⁇ except that phase, average particle diameter, manufacturers, and titanium dioxide powders having different doping or coating forms were used.
- the types of titanium dioxide are summarized in Table 1 below.
- a tooth whitening composition was prepared in the same manner as in Example 1, except that the titanium dioxide powders of Preparation Examples 3 to 6 were used, respectively. Comparative Examples 1 to 12
- compositions for tooth whitening were prepared in the same manner as in Example 1, except that the titanium dioxide powders of Preparation Example 1 and Preparation Examples 7 to 17 were used, respectively. Comparative Example 13
- aqueous hydrogen peroxide solution and methylene blue were mixed in a titanium dioxide colloidal solution of Preparation Examples 1 to 17, and 100 ppm of the mixture was injected into a 96 well plate.
- the concentration of lithium and titanium dioxide was set to 0.05 nig / ml.
- Methylene blue has a maximum absorbance at 660 nm, which can be measured by measuring the change in absorbance at this wavelength.
- the degree of decomposition of the titanium dioxide solutions of Preparation Examples 1 to 17 and only 30% of hydrogen peroxide aqueous solution was measured and shown in the graph of FIG. 1.
- uncoated or doped rutile titanium dioxide includes anatase type titanium dioxide (preparation examples 9 to 11, and preparation example 13), amorphous titanium dioxide in all average particle diameter ranges (preparation examples 1 to 6).
- Preparation Examples 12, 14, 15, and 16) and anatase-rutile combinations (Preparation Example 8) showed higher activities. In addition, the activity was higher than those of Preparation Example 7, Preparation Example 9 : Preparation Example 14, Preparation Example 15, and Preparation Example 17 in which the titanium dioxide particles were doped or coated with other elements.
- the photoactivity of the rutile titanium dioxide generally increased in proportion to the size of the particles. In the range where the average particle diameter was 30 nm or more, similar photoactivity was exhibited.
- Preparation Examples 4 and 5 having an average particle diameter of 100 nm and Preparation Example 6 having an average particle diameter of 165 nm showed the highest optical activity, even in the visible wavelength range. Show activity at As high as whitening activity.
- Preparation Example 1 having an average particle diameter of 20 nm the light activity was lower than that of 30 nm or more.
- composition containing only hydrogen peroxide without the titanium dioxide of Preparation Example 18 has little methylene blue decomposition activity, which indirectly shows that there will be little whitening effect in the absence of photoactivation. Tooth whitening effect evaluation
- Teeth extracted for periodontal inflammation and orthodontics were immediately frozen after disinfection.
- To color the teeth the mixture of green tea and coffee was placed in a 50 ml conical tube and the teeth were soaked in the tube and shaken for 2 weeks at 36 degrees Celsius.
- Example 3 After 2 weeks the pigmented teeth were divided into 2 groups of 10 each at random.
- the whitening composition of Example 3 was applied to one group, and Zoom2 of Comparative Example 13 was applied to the other group.
- Example 3 and Comparative Example 13 were applied to the teeth and then irradiated with light for 15 minutes using an LED of 380 nm. This process was repeated three times.
- the whitening results were evaluated in two ways 7 days after application.
- One is a visual evaluation method using a shade guide (Vitapan Classical Shade Guide, Bad Sackingen, Germany), and the other is a digital evaluation method using a digital camera (Nikon D90, Nikon, Japan).
- the Vitapan Classical shade guide is available from Bl to C4 (B l, Al, B2, D2, A2, CI, C2, D4, A3, D3, B3, A3.5, B4, C3, A4). , C4), and each shade tab has a number from 1 to 16. Visual color evaluation was based on this shade guide.
- the statistical method was t-test (significance level 0.05).
- Example 3 showed similar results in visual evaluation and better results in digital evaluation compared to Comparative Example 13.
- Figure 2 shows the teeth before and after application of the composition for tooth whitening of Example 3 and Comparative Example 13. .
- Example 3 showed 11 step changes in visual evaluation, and 10.47 color changes in digital evaluation.
- Comparative Example I 3 showed a 10-step change in visual evaluation, and a color change of 7.31 in digital evaluation.
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BR112016006551A BR112016006551A2 (pt) | 2013-09-27 | 2014-09-25 | composição para branqueamento dos dentes |
CN201480053540.4A CN105579023A (zh) | 2013-09-27 | 2014-09-25 | 用于漂白牙齿的组合物 |
US15/024,886 US9795546B2 (en) | 2013-09-27 | 2014-09-25 | Composition for bleaching tooth |
EP14848546.9A EP3050553A4 (en) | 2013-09-27 | 2014-09-25 | COMPOSITION FOR CALCULATION |
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KR102331905B1 (ko) | 2021-03-18 | 2021-12-01 | 쿼럼바이오 주식회사 | 치아 미백 조성물 및 이를 이용하는 치아 미백 방법 |
CN113350211A (zh) * | 2021-07-05 | 2021-09-07 | 成都世联康健生物科技有限公司 | 一种芬顿组合物、制法及在制备牙齿美白产品中的应用 |
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KR20020033650A (ko) * | 1999-07-02 | 2002-05-07 | 이시바시 다쿠로 | 치아표백제 조성물 및 변색치아 표백방법 |
KR20030076632A (ko) * | 2001-01-29 | 2003-09-26 | 미츠비시 가스 가가쿠 가부시키가이샤 | 치아 표백재 및 치아의 표백 방법 |
JP2004292429A (ja) * | 2003-03-10 | 2004-10-21 | Gc Corp | 歯牙用漂白剤セット及び歯牙漂白方法 |
JP2007161623A (ja) * | 2005-12-12 | 2007-06-28 | Mitsubishi Gas Chem Co Inc | 歯牙漂白材および歯牙漂白方法 |
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KR20020033650A (ko) * | 1999-07-02 | 2002-05-07 | 이시바시 다쿠로 | 치아표백제 조성물 및 변색치아 표백방법 |
KR20030076632A (ko) * | 2001-01-29 | 2003-09-26 | 미츠비시 가스 가가쿠 가부시키가이샤 | 치아 표백재 및 치아의 표백 방법 |
JP2004292429A (ja) * | 2003-03-10 | 2004-10-21 | Gc Corp | 歯牙用漂白剤セット及び歯牙漂白方法 |
JP2007161623A (ja) * | 2005-12-12 | 2007-06-28 | Mitsubishi Gas Chem Co Inc | 歯牙漂白材および歯牙漂白方法 |
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US9795546B2 (en) | 2017-10-24 |
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BR112016006551A2 (pt) | 2017-08-01 |
CN105579023A (zh) | 2016-05-11 |
KR101436126B1 (ko) | 2014-09-01 |
EP3050553A1 (en) | 2016-08-03 |
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