WO2015022559A1 - Composition pharmaceutique contenant de la rosuvastatine et du ramipril - Google Patents
Composition pharmaceutique contenant de la rosuvastatine et du ramipril Download PDFInfo
- Publication number
- WO2015022559A1 WO2015022559A1 PCT/HU2014/000071 HU2014000071W WO2015022559A1 WO 2015022559 A1 WO2015022559 A1 WO 2015022559A1 HU 2014000071 W HU2014000071 W HU 2014000071W WO 2015022559 A1 WO2015022559 A1 WO 2015022559A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ramipril
- pharmaceutical composition
- ram
- rosuvastatin
- granulate
- Prior art date
Links
- 229960003401 ramipril Drugs 0.000 title claims abstract description 67
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 title claims abstract description 65
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 title claims abstract description 38
- 229960000672 rosuvastatin Drugs 0.000 title claims abstract description 38
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 18
- 239000000203 mixture Substances 0.000 claims abstract description 44
- 239000004480 active ingredient Substances 0.000 claims abstract description 40
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 239000008187 granular material Substances 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 21
- 229960000528 amlodipine Drugs 0.000 claims description 14
- 238000005469 granulation Methods 0.000 claims description 10
- 230000003179 granulation Effects 0.000 claims description 10
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
- 206010020772 Hypertension Diseases 0.000 claims description 7
- 239000007931 coated granule Substances 0.000 claims description 7
- 239000003085 diluting agent Substances 0.000 claims description 7
- 238000005243 fluidization Methods 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical group C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 5
- 238000007908 dry granulation Methods 0.000 claims description 5
- 238000005550 wet granulation Methods 0.000 claims description 5
- 239000007884 disintegrant Substances 0.000 claims description 4
- 239000008240 homogeneous mixture Substances 0.000 claims description 4
- 229960000913 crospovidone Drugs 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 229960003943 hypromellose Drugs 0.000 claims description 3
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 3
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 3
- 208000035150 Hypercholesterolemia Diseases 0.000 claims description 2
- 229920003125 hypromellose 2910 Polymers 0.000 claims description 2
- 229940031672 hypromellose 2910 Drugs 0.000 claims description 2
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims 1
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 description 17
- 239000012535 impurity Substances 0.000 description 17
- 238000000354 decomposition reaction Methods 0.000 description 10
- 101100258233 Caenorhabditis elegans sun-1 gene Proteins 0.000 description 9
- 239000002775 capsule Substances 0.000 description 9
- 238000003860 storage Methods 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000011575 calcium Substances 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 229960004005 amlodipine besylate Drugs 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000000265 homogenisation Methods 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- DMBUODUULYCPAK-UHFFFAOYSA-N 1,3-bis(docosanoyloxy)propan-2-yl docosanoate Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCCCCCC DMBUODUULYCPAK-UHFFFAOYSA-N 0.000 description 3
- 229910002012 Aerosil® Inorganic materials 0.000 description 3
- 235000019888 Vivapur Nutrition 0.000 description 3
- 238000005056 compaction Methods 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000013583 drug formulation Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 150000002596 lactones Chemical class 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- GNWCZBXSKIIURR-UHFFFAOYSA-N (2-docosanoyloxy-3-hydroxypropyl) docosanoate Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCCCCCCC GNWCZBXSKIIURR-UHFFFAOYSA-N 0.000 description 1
- KEDYTOTWMPBSLG-GCGVSIEWSA-N 1-[(2s)-2-[[(1s)-1-carboxy-3-phenylpropyl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2h-cyclopenta[b]pyrrole-2-carboxylic acid Chemical compound C([C@H](N[C@@H](C)C(=O)N1C(CC2CCCC21)C(O)=O)C(O)=O)CC1=CC=CC=C1 KEDYTOTWMPBSLG-GCGVSIEWSA-N 0.000 description 1
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 description 1
- 102100029077 3-hydroxy-3-methylglutaryl-coenzyme A reductase Human genes 0.000 description 1
- 101710158485 3-hydroxy-3-methylglutaryl-coenzyme A reductase Proteins 0.000 description 1
- JDQPWFOELBINQE-UHFFFAOYSA-N 4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid Chemical compound CC=1NC=C(C(C=1C(=O)O)C1=C(C=CC=C1)Cl)C(=O)O JDQPWFOELBINQE-UHFFFAOYSA-N 0.000 description 1
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
- 150000008107 benzenesulfonic acids Chemical class 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 229940049654 glyceryl behenate Drugs 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000008185 minitablet Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000008385 outer phase Substances 0.000 description 1
- 238000006864 oxidative decomposition reaction Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229940014007 ramipril and amlodipine Drugs 0.000 description 1
- KEDYTOTWMPBSLG-HILJTLORSA-N ramiprilat Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)C(O)=O)CC1=CC=CC=C1 KEDYTOTWMPBSLG-HILJTLORSA-N 0.000 description 1
- LALFOYNTGMUKGG-BGRFNVSISA-L rosuvastatin calcium Chemical compound [Ca+2].CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O.CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O LALFOYNTGMUKGG-BGRFNVSISA-L 0.000 description 1
- 229960004796 rosuvastatin calcium Drugs 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Definitions
- the invention concerns a wide range of pharmaceutical compositions.
- the technical field of the invention is the combination composition containing several active ingredient in one dosage form.
- the invention can be grouped into the combination compositions containing ramipril.
- Ramipril, (2S, 3aS, 6aS) -1 [ (S) -N- [ (S) -l-carboxy-3- phenylpropyl ] -alanyl-octahydrocyclopenta- [b] pyrrole-2-carboxylic acid-ethlyester, is a known drug active ingredient, which is used in the therapy to treat hypertension, heart failure, nephropathy, to promote revascularisation, to decrease the risk of cardiovascular diseases and events, especially stroke and myocardial infarction, and to decrease cardiovascular mortality.
- the active ingredient ramipril is sensitive to heat and moisture and decomposes easily. During the decomposition the hydrolysis of the ester groups occurs, which results the impurity corresponding to the active metabolite, that is the ramiprilate (European Pharmacopoeia: Impurity E) .
- the concentration of the decomposition product diketopiperazine in the product can reach 22.8%, in case of ramipril capsules filled with powder mixture containing 2.5 mg of active ingredient can reach 6.4%, respectively.
- the oxidative decomposition of ramipril in the presence of air can result in undesired discoloration.
- Rosuvastatin is the selective and competitive inhibitor of
- Rosuvastatin is used for medical purposes in the form of its pharmaceutically acceptable salts, primarily as the calcium salt or as the zinc salt. Rosuvastatin is an active ingredient of Class III of the Biopharmaceutics Classification System (BCS) , which has a high solubility in water and in body fluids.
- BCS Biopharmaceutics Classification System
- Amlodipine is hard to tablet and easily decomposes. Amlodipine is used in pharmaceutical compositions in the form of benzenesulfonic acid salt, i.e. amlodipine besylate. It is known from the international publication No. WO2010038091 that in combination compositions amlodipine easily interacts undesirably with the second active ingredient, which leads to decomposition reactions. Due to the hydrolysis of amlodipine besylate in the presence of moisture it is expected that mixing it directly with ramipril the fast decomposition of ramipril will occur in the resulting acidic medium.
- Chinese patent application No. CN101658675 describes several combination compositions, however, does not describe the stability and release features of the compositions. Furthermore, the patent application neither describes the drug formulation containing ramipril and rosuvastatin simultaneously.
- the object of our invention is therefore to develop a drug formulation containing ramipril, which applied in a unit dose combination eliminates the incompatibility occurring between ramipril and rosuvastatin described above.
- the mixture of 10 - 50 m/m% of ramipril and 50 - 90 m/m% of the diluent calculated to the weight of the coated granules is dry compacted during the dry granulation.
- the step of the wet granulation fluidization granulation or vortex granulation can preferably be used.
- 1 - 10 m/m% binder is used calculated to the weight of the coated granules.
- ramipril granules according to the invention are produced according to the following process:
- the diluent is preferably crospovidone
- the binder is preferably hypromellose .
- a further object of the invention is the ramipril granule prepared by any of the above described processes.
- the ramipril granule according to the invention preferably contains crosslinked PVP and/or HPMC.
- a further object of the invention is a pharmaceutical composition containing ramipril granules according to the invention .
- a further object of the invention is a pharmaceutical composition containing ramipril granules according to the invention and rosuvastatin .
- the pharmaceutical composition according to the invention contains also amlodipine.
- a further object of the present invention is the pharmaceutical use of the pharmaceutical composition of the invention, especially for the treatment of hypertension and to decrease high cholesterol level.
- the active ingredients remain stable during manufacture and storage, i.e. in the composition, or the level of impurities formed during the manufacture does not exceed the level of the approved impurities relating to the given active ingredient of the mono-composition,
- bioavailability of the combination composition shall be similar or identical to the one, if two or three mono- compositions are administered together, which correspond to the active ingredient content of the combination composition,
- the aimed compositions with similar effect and that are preferably bioequivalent are suitable for - in case of already treated patients - switching without risk the simultaneous administration of two or three compositions to the combination composition.
- This has a particular importance in the treatment of patients with hypertension, because setting the blood pressure by using different active ingredients generally needs longer time, and there is a risk that the effect of the new combination does not reach the required level.
- the drug search- setting process can last for even months, while the side effects (dizziness, headache, etc.) caused by the hypertension significantly decrease the life quality of the patient, and formation and/or progression of the accompanying diseases are not inhibited.
- the combination composition is bioequivalent, than the long process of the setting and the risks can be avoided.
- release profiles do not change during storage time, as a composition with altered release profile can not exert the same effect. Namely, if the release profile of any of the active ingredients changes, the bioavailability can also deviate, and the composition will not be suitable either to replace the corresponding mono-compositions or to use it as a drug.
- Our invention is therefore a solid combination pharmaceutical composition containing ramipril and rosuvastatin and optionally amlodipine or pharmaceutically acceptable salts or complexes thereof.
- the coated ramipril containing granulate by the following method:
- disintegrant is preferably crosslinked polyvinylpyrrolidone (e.g. polyplasdone XL 10) is dry-compacted, and compacts are regranulated and coated by 5-10%, preferably 5-8% aqueous solution of 1-15 m/m%, preferably 1-10 m/m%, more preferably 2-6 m/m% HPMC calculated to the weight of the coated granule.
- crosslinked polyvinylpyrrolidone e.g. polyplasdone XL 10
- compacts are regranulated and coated by 5-10%, preferably 5-8% aqueous solution of 1-15 m/m%, preferably 1-10 m/m%, more preferably 2-6 m/m% HPMC calculated to the weight of the coated granule.
- ramipril and crosslinked polyvinylpyrrolidone (PVP), preferably polyplasdon XL 10
- PVP polyvinylpyrrolidone
- the obtained compact is subjected to regranulation on a sieve of 0.6 mm, than on 0.5 mm hole size and afterwards homogenized.
- the obtained homogenized granulate is coated with an aqueous solution of 6 m/m% HPMC in a fluidization granulation apparatus.
- the resulting coated granules are optionally homogenized with part of the microcrystalline cellulose used for the outer phase, and afterwards the rest of the microcrystalline cellulose and aerosil R972 is added to the obtained mixture.
- compritol 888 glyceryl behenate
- Amlodipine besylate (AMD 12 VT) 13.900 mg
- Preparation of the granulate is made by a two-step granulation, first dry granulation (compaction) , than wet granulation occurs.
- first dry granulation (compaction)
- wet granulation occurs.
- the necessary amount of active ingredient and additive is mixed, sieved, homogenized followed by compaction by a dry granulation apparatus, than regranulation and homogenization occurs, and the further granulation follows in a fluidization granulation apparatus by spraying the granulation solution.
- the material with an appropriate drying loss is preferably homogenized after regranulation .
- the active ingredient rosuvastatin is sensitive to light, therefore the strong lighting during the whole manufacturing process shall be avoided.
- the preferably sieved magnesium stearate of vegetable origin is added during the manufacturing process to materials of the prehomogenized internal phase (Rosuvastatin Ca compact and Prosolv HD 90) , than the press-ready end-homogenizate is prepared by end-homogenization, which can preferably be tableted in a rotary tablet press.
- the flow diagram of the preparation of the combination composition is the following:
- Preparation of the amlodipine compact occurs preferably by multiple steps of mixing, sieving, regranulation and homogenization of amlodipine besylate (AMD 12 VT) and Vivapur 200
- amlodipine is used in the combination composition, than preferably the prepared amlodipine granulate is mixed with the Ramipril granulate and further agents (Aerosil R 972, Vivapur 200), homogenized, and after the addition of Compritol 888 the end-homogenizate is prepared by homogenization.
- the end- homogenizate containing the Ramipril and optionally Amlodipine is filled into the capsule shells, and as the second step Rosuvastatin Ca tbl 20 mg (0.02 M) is filled onto the homogenizate .
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne une composition combinée contenant de la rosuvastatine et du ramipril, et éventuellement de l'amlodipine, et la préparation de cette composition. Les principes actifs sont séparés l'un de l'autre dans ladite composition.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUP1300496 | 2013-08-16 | ||
HU1300496A HUP1300496A2 (hu) | 2013-08-16 | 2013-08-16 | Stabil kombinációs gyógyszerkészítmény |
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WO2015022559A1 true WO2015022559A1 (fr) | 2015-02-19 |
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PCT/HU2014/000071 WO2015022559A1 (fr) | 2013-08-16 | 2014-08-15 | Composition pharmaceutique contenant de la rosuvastatine et du ramipril |
PCT/HU2014/000072 WO2015022560A1 (fr) | 2013-08-16 | 2014-08-15 | Composition pharmaceutique stable contenant du bisoprolol et du ramipril |
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PCT/HU2014/000072 WO2015022560A1 (fr) | 2013-08-16 | 2014-08-15 | Composition pharmaceutique stable contenant du bisoprolol et du ramipril |
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EA (1) | EA033291B1 (fr) |
HU (2) | HUP1300496A2 (fr) |
WO (2) | WO2015022559A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3501502A1 (fr) * | 2017-12-20 | 2019-06-26 | Midas Pharma GmbH | Compositions pharmaceutiques dosées fixes comprenant de l'amlodipine, du ramipril et de l'atorvastatine |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021160700A1 (fr) | 2020-02-10 | 2021-08-19 | Adamed Pharma S.A. | Composition comprenant du ramipril et de l'indapamide |
CN115068434B (zh) * | 2022-08-03 | 2023-05-09 | 昆山龙灯瑞迪制药有限公司 | 一种雷米普利片的制备方法 |
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- 2014-08-15 WO PCT/HU2014/000072 patent/WO2015022560A1/fr active Application Filing
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---|---|---|---|---|
EP3501502A1 (fr) * | 2017-12-20 | 2019-06-26 | Midas Pharma GmbH | Compositions pharmaceutiques dosées fixes comprenant de l'amlodipine, du ramipril et de l'atorvastatine |
WO2019121857A1 (fr) * | 2017-12-20 | 2019-06-27 | Midas Pharma GmbH | Compositions pharmaceutiques à doses fixes comprenant de l'amlodipine, du ramipril et de l'atorvastatine |
Also Published As
Publication number | Publication date |
---|---|
HU231052B1 (hu) | 2020-02-28 |
WO2015022560A1 (fr) | 2015-02-19 |
HUP1600414A2 (hu) | 2016-09-28 |
EA033291B1 (ru) | 2019-09-30 |
EA201690395A1 (ru) | 2016-07-29 |
HUP1300496A2 (hu) | 2015-03-02 |
WO2015022560A8 (fr) | 2015-05-14 |
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