WO2014199847A1 - Dispositif de capture d'image de cellules endothéliales cornéennes - Google Patents

Dispositif de capture d'image de cellules endothéliales cornéennes Download PDF

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Publication number
WO2014199847A1
WO2014199847A1 PCT/JP2014/064423 JP2014064423W WO2014199847A1 WO 2014199847 A1 WO2014199847 A1 WO 2014199847A1 JP 2014064423 W JP2014064423 W JP 2014064423W WO 2014199847 A1 WO2014199847 A1 WO 2014199847A1
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WIPO (PCT)
Prior art keywords
corneal endothelial
endothelial cell
fixation target
light
main body
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PCT/JP2014/064423
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English (en)
Japanese (ja)
Inventor
兼一 坂上
将 中島
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株式会社トプコン
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Publication of WO2014199847A1 publication Critical patent/WO2014199847A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/107—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining the shape or measuring the curvature of the cornea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/0075—Apparatus for testing the eyes; Instruments for examining the eyes provided with adjusting devices, e.g. operated by control lever
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/14—Arrangements specially adapted for eye photography

Definitions

  • the present invention relates to a corneal endothelial cell imaging apparatus for imaging corneal endothelial cells.
  • Such a corneal endothelial cell imaging device includes a slit light irradiation optical system that irradiates slit light obliquely toward the cornea of an eye to be examined, and a cornea that receives reflected light from the corneal endothelial cells of the cornea and images the corneal endothelial cells. And an endothelial cell photographing optical system.
  • a slit light irradiation optical system that irradiates slit light obliquely toward the cornea of an eye to be examined, and a cornea that receives reflected light from the corneal endothelial cells of the cornea and images the corneal endothelial cells.
  • an endothelial cell photographing optical system In such an apparatus for photographing corneal endothelial cells, photographing is performed with the subject's eye fixed, so the corneal endothelial cells in the central part of the cornea are photographed.
  • the fixation target in the periphery is difficult to see for the subject, and in particular, the external fixation target is difficult to see, and there is a problem that the gaze of the subject cannot be promptly guided. It was.
  • An object of the present invention is to provide a corneal endothelial cell imaging apparatus capable of promptly guiding a subject's line of sight to a fixed fixation target.
  • the invention according to claim 1 is a slit light irradiation optical system that irradiates slit light obliquely toward the cornea of an eye to be examined, and a corneal endothelium that receives reflected light from the corneal endothelial cells of the cornea and images the corneal endothelial cells.
  • An endothelial cell photographing optical system, an internal fixation target, an external fixation target, and the alignment detection means are provided in the apparatus main body, and the apparatus main body can move back and forth, right and left, up and down with respect to the eye to be examined.
  • a photographing device When the plurality of portions of the cornea are sequentially photographed by sequentially changing the fixation target to be lit, the apparatus main body is temporarily retracted every time photographing is completed.
  • the subject's line of sight can be promptly guided to the fixation target.
  • FIG. 1 is an optical layout diagram showing an optical system of a corneal endothelial cell imaging apparatus according to the present invention.
  • FIG. 5 is an optical arrangement diagram showing arrangement of optical members of an alignment index projection optical system and an internal fixation target projection optical system.
  • a corneal endothelial cell imaging device 100 shown in FIGS. 1 to 3 includes a base portion 302 provided on a base 301, and a device main body 303 provided on the base portion 302 and movable in the front, rear, left, right, up and down directions.
  • the jaw holder 305 provided on the upper part of the support 304 attached to the front part of the base 301, the forehead 307 held by the holding member 306 provided on the support 304, and the apparatus main body 303 are provided.
  • a display unit 310 is provided on the upper part of the support 304 attached to the front part of the base 301, the forehead 307 held by the holding member 306 provided on the support 304, and the apparatus main body 303.
  • the display unit 310 displays an imaged anterior segment image or corneal endothelial cell image, and can be freely moved to a desired position by motor control or manually.
  • a touch panel 312 (see FIG. 10) is attached to the screen of the display unit 310. By touching the touch panel 312, the apparatus main body 303 is moved in the front-rear direction, the up-down direction, and the left-right direction with respect to the eye to be examined. In addition to the above, various mode settings and operations can be performed.
  • an optical system of the corneal endothelial cell imaging apparatus 100 that images corneal endothelial cells is arranged.
  • the apparatus main body 303 On the front surface of the apparatus main body 303, as shown in FIG. 4, six external fixation target light sources 321 to 326 that are external fixation targets and four anterior segment illumination light sources that illuminate the anterior segment of the eye to be examined. 1, the slit light irradiation window 341 for irradiating the slit light toward the cornea of the eye to be examined, the incident window 342 into which the reflected light of the slit light reflected by the cornea enters, and the anterior eye portion of the eye to be examined are observed. Observation window 343 is provided.
  • the external fixation target light sources 321 to 326 and the anterior ocular segment illumination light source 1 are composed of, for example, light emitting diodes.
  • the external fixation target light sources 321 to 326 emit light when photographing corneal endothelial cells at a position far away from the central portion of the cornea.
  • the optical system of the corneal endothelial cell imaging apparatus 100 includes an anterior ocular segment observation optical system 10 for observing the anterior segment of the eye E and a corneal endothelial cell S2 of the eye E (see FIG. 8).
  • the anterior ocular segment observation optical system 10 includes an alignment index projection optical system 40 that projects an alignment index for detecting X and Y alignment, an alignment detection optical system 50 that detects X and Y alignment, and an internal fixation target. And an internal fixation target projection optical system 70 for projecting.
  • the corneal endothelial cell imaging optical system 30 is provided with a focusing position detection optical system (Z alignment detection optical system) 60.
  • the alignment index projection optical system 40, the alignment detection optical system 50, and the in-focus position detection optical system 60 constitute an alignment detection means.
  • the anterior ocular segment observation optical system 10 includes a half mirror 11, an objective lens 12, a half mirror 13, a diaphragm 14, an imaging lens 15, a light shielding plate 16, a CCD (light receiving element) 17, and the like. ing. O1 is the optical axis.
  • Adjustment index projection optical system As shown in FIG.
  • the alignment index projection optical system 40 includes an alignment index light source (point light source) 41 made of a light emitting diode, a condenser lens 42, a half mirror 43, a projection lens 44, and the half mirror 11.
  • 343G is a transparent observation window glass provided in the observation window 343.
  • the alignment detection optical system 50 includes a two-dimensional PSD (alignment detection sensor: position sensor) 51 as a position detection unit, and the half mirror 13 and the objective lens 12 of the anterior ocular segment observation optical system 10. And the half mirror 11 and the like are shared.
  • the alignment detection sensor 51 is disposed at a position conjugate with the virtual image R formed by the alignment index light at a substantially intermediate position between the corneal apex P and the corneal curvature center Q3 with respect to the objective lens 12.
  • Cornea reflection light based on the alignment index light enters the observation window 343 of the apparatus main body 303 and is guided to the objective lens 12.
  • a part of the light beam collected by the objective lens 12 is reflected by the half mirror 13 and imaged on the alignment detection sensor 51.
  • a detection signal corresponding to the position of the virtual image R image R ′ (not shown) of the alignment index light imaged on the alignment detection sensor 51 is output from the alignment detection sensor 51, and based on this detection signal.
  • a deviation amount between the left and right (X direction) and the top and bottom (Y direction) of the apparatus main body with respect to the eye E is detected.
  • the illumination light from the anterior segment illumination light source 1 is reflected by the cornea C, passes through the half mirror 11 and is guided to the objective lens 12.
  • a part of the light beam transmitted through the objective lens 12 is imaged on the CCD 17 by the imaging lens 15 after passing through the half mirror 13.
  • the signal detected by the CCD 17 is sent to the display unit 310 (see FIG. 10).
  • an image R ′′ of a virtual image R of the alignment index light is also formed on the CCD 17 at the same time. Therefore, as shown in FIG. On the screen 18, the anterior segment image E ′ of the eye E and the virtual image R ′′ of the alignment index light are displayed simultaneously.
  • symbol A is an annular pattern image indicating an allowable range of XY alignment in the left-right direction (X direction) and the up-down direction (Y direction), which is electrically displayed on the display unit 310. .
  • the examiner performs XY alignment by moving the apparatus body of the corneal endothelial cell imaging apparatus 100 so that the virtual image R ′′ falls within the range of the annular pattern image A.
  • the light shielding plate 16 shown in FIG. 5 is inserted into the optical path of the anterior ocular segment observation optical system 10 when observing and photographing corneal endothelial cells, and is detached from the optical path when observing the anterior segment.
  • the light path of the light shielding plate 16 is inserted / removed by a solenoid (not shown).
  • the internal fixation target projection optical system 70 includes a central fixation light-emitting diode (internal fixation target light source) 71 and a wide-angle light-emitting diode (internal fixation target).
  • Light sources 72 and 73 Light sources 72 and 73, a projection lens 44, light emitting diodes (internal fixation target light sources) 74a to 74h for internal peripheral fixation, and the half mirror 11.
  • the fixation light beam emitted from the light emitting diodes 71 to 73 is transmitted through the half mirror 43, converted into a parallel light beam by the projection lens 44, and projected onto the eye E through the half mirror 11 and the observation window glass 343G.
  • the fixation light beam emitted from the light emitting diodes 74a to 74h is projected onto the eye E through the half mirror 11 and the observation window glass 343G.
  • the light emitting diode 71 is turned on when photographing the central portion of the cornea C, the light emitting diodes 72 and 73 are turned on when photographing portions on both sides sandwiching the central portion, and the light emitting diodes 74a to 74h surround these portions. Light is emitted when photographing a peripheral part (inner peripheral part).
  • the light emitting diodes 74a to 74h may be arranged on the outer periphery in the same plane as the light emitting diodes 71 to 73. In this case, in addition to disposing individual light sources as shown in the figure, a two-dimensional display element such as a liquid crystal may be disposed to light only necessary portions.
  • the external fixation target light sources 321 to 326 are made to emit light when photographing the outer peripheral portion (outer peripheral portion) of the inner peripheral portion.
  • the corneal endothelial cell illumination optical system 20 includes an observation illumination optical system 120 and a photographing illumination optical system 220.
  • the observation illumination optical system 120 is an observation light source (infrared LED: illumination light source). ) 21, a slit 22, a dichroic mirror 23, an objective lens 24, and the like.
  • O2 is the optical axis.
  • the observation light beam emitted from the observation light source 21 passes through the slit 22, is reflected by the dichroic mirror 23, and is guided to the objective lens 24.
  • the observation light beam which is the slit illumination light condensed by the objective lens 24 illuminates the cornea C.
  • the photographing illumination optical system 220 includes a photographing illumination light source (photographing light source) 25 made of a white light emitting diode, a condenser mirror 226, a condenser lens 26, a slit 27, and the like, and an observation illumination optical system. 120 dichroic mirrors 23 and objective lens 24 are shared.
  • the imaging light source 25 may be a monochromatic light emitting diode that emits, for example, green or blue light.
  • the illumination light emitted from the photographing light source 25 is condensed by the condenser lens 26.
  • the illumination light is used as photographic light and passes through the slit 27 to become slit illumination light.
  • the slit illumination light in the visible wavelength region passes through the dichroic mirror 23, and the slit illumination light in the visible wavelength region is transmitted. It is guided to the objective lens 24.
  • the cornea C is illuminated by the slit illumination light transmitted through the objective lens 24.
  • the corneal endothelial cell imaging optical system 30 includes an objective lens 31, a half mirror 32, a mirror 34, a relay lens 35, a mask plate 130, a relay lens 132, a light shielding plate 131, a mirror 36, a CCD 17, and the like. O3 is this optical axis.
  • the mask plate 130 is disposed at a position conjugate with a line sensor and a CCD 17 described later.
  • the light shielding plate 131 is inserted into the optical path of the corneal endothelial cell imaging optical system 30 when observing the anterior segment of the eye, and is detached from the optical path when observing and capturing corneal endothelial cells. Insertion and removal are performed by a solenoid (not shown).
  • the slit illumination light reflected by the cornea C is guided to the objective lens 31.
  • Part of the reflected light beams R 1, R 2, R 3 (see FIG. 8) guided to the objective lens 31 passes through the half mirror 32 and enters the mask plate 130 via the mirror 34 and the relay lens 35.
  • the mask plate 130 is arranged so that the portions of the reflected light beams R1 and R3 from the corneal surface are shielded and the reflected light beam R2 of the corneal endothelial cells is transmitted while the alignment with the eye E is matched. .
  • the focus position detection optical system 60 includes an objective lens 31, a half mirror 32, and a line sensor 61.
  • the line sensor 61 is disposed substantially at a conjugate position with the cornea C, and optically along a direction corresponding to the thickness direction of the cornea C as shown in FIG.
  • FIG. 10 is a block diagram showing the configuration of the control system of the corneal endothelial cell imaging apparatus 100.
  • reference numeral 101 denotes a focus determination circuit that detects whether the corneal endothelial cell photographing optical system 30 is focused on the corneal endothelial cell S2 based on the light amount distribution of the line sensor 61.
  • the focus determination circuit 101 outputs a focus signal corresponding to the separation distance between the peak V of the intensity distribution of the reflected light beam shown in FIG. 11 and the center address Q of the line sensor 61, and the peak V and the center address Q coincide with each other. When this is done, a focus completion signal is output.
  • the apparatus main body 303 of the corneal endothelial cell imaging apparatus 100 When the apparatus main body 303 of the corneal endothelial cell imaging apparatus 100 is moved away from the eye E, the address of the peak V moves.
  • the apparatus main body 303 is set so that the corneal endothelial cell is focused when the address L of the peak V coincides with the center address Q. That is, when the Z alignment is completed, the corneal endothelial cell imaging optical system 30, that is, the corneal endothelial cell imaging device 100 is focused on the corneal endothelial cell S2.
  • Reference numeral 102 denotes an alignment determination circuit that determines alignment in the X and Y directions.
  • the alignment determination circuit 102 is based on a detection position of a signal by a virtual image R ′ (not shown) of alignment index light on the alignment detection sensor 51.
  • R ′ virtual image
  • the right and left (X direction) deviation amount and the vertical (Y direction) deviation amount between the optical axis of the eye E and the optical axis O1 of the apparatus main body 303 are determined.
  • the control device 104 controls the drivers D1 to D3 for driving the X, Y, and Z motors 201 to 203 based on the focus signal output from the focus determination circuit 101 and the amount of deviation in the X and Y directions determined by the alignment determination circuit 102. It is a control device.
  • the control device 104 displays the image on the display unit 310 based on the image on the CCD 17, or the anterior ocular segment illumination light source 1, the alignment index light source 41, the imaging light source 25, based on the operation of an operation unit (not shown). Light emission of the observation light source 21 and the like is controlled.
  • the control device 104 controls the light emission of the external fixation target light sources 321 to 326, the light emitting diodes 71 to 73, and the light emitting diodes 74a to 74h based on the operation of the operation unit.
  • X, Y, and Z motors 201 to 203 are motors that move the apparatus main body 303 of the corneal endothelial cell imaging apparatus 100 in the X, Y, and Z directions. [Operation] Next, the operation of the corneal endothelial cell imaging apparatus 100 configured as described above will be described.
  • the anterior segment illumination light source 1 shown in FIG. the light shielding plate 16 is retracted from the optical path, and the light shielding plate 131 is inserted into the optical path.
  • the illumination light from the anterior segment illumination light source 1 is reflected by the cornea C, and this reflected light enters the observation window 343 and passes through the half mirror 11, the objective lens 12, the half mirror 13, the stop 14, and the imaging lens 15.
  • the image of the anterior segment is formed on the CCD 17. Then, as shown in FIG. 7, the anterior segment image E ′ is displayed on the screen 18 of the display unit 310.
  • the internal fixation target projection optical system 70 causes the center fixation light-emitting diode 71 to emit light to fix the eye E to be examined.
  • the alignment index light source 41 of the alignment index projection optical system 40 (see FIG. 5A) emits light and emits alignment index light.
  • the alignment index light is condensed by the condenser lens 42 and reaches the projection lens 44 through the half mirror 43, and is converted into a parallel light beam K (see FIG. 6) by the projection lens 44. It is projected onto the cornea C of the optometry E.
  • the cornea reflected light based on the alignment index light enters the observation window 343, passes through the objective lens 12, is reflected by the half mirror 13, and an image R ′ (not shown) by the alignment index light is formed on the alignment detection sensor 51. Imaged.
  • the corneal reflection light transmitted through the half mirror 13 reaches the imaging lens 15, and an image R ′′ as a virtual image R (see FIG. 6) of the alignment index light is simultaneously formed on the CCD 17 by the imaging lens 15.
  • the anterior segment image E ′ of the eye E and the virtual image R ′′ of the alignment index light are displayed on the screen 18 of the display unit 310.
  • the examiner touches a predetermined portion of the touch panel 12 of the display unit 310 so that the virtual image R ′′ falls within the range of the annular pattern image A drawn electronically on the screen, thereby moving the apparatus main body 303 up and down. Move left and right to perform XY alignment.
  • the alignment determination circuit 102 obtains a deviation amount in the X and Y directions with respect to the apparatus main body 303 with respect to the eye E from the position of the image R ′ formed on the alignment detection sensor 51, and this deviation amount. Accordingly, the control device 104 controls the drivers D1 and D2 to move the device main body 303 in the X and Y directions to perform XY alignment.
  • the observation light beam emitted from the observation light source 21 shown in FIG. 5 illuminates the cornea C with the slit illumination light of infrared light as shown in FIG. 8 through the slit 22, the dichroic mirror 23 and the objective lens 24.
  • the reflected light beam by the slit illumination light from the cornea C includes a reflected light beam R1 on the surface of the cornea C, a reflected light beam R2 of the corneal endothelial cell S2, and a reflected light beam R3 of the corneal substance S3.
  • the slit illumination light reflected by the cornea C enters the incident window 342 shown in FIG. 1 and is guided to the objective lens 31, and part of the reflected light beams R 1, R 2, R 3 is reflected by the half mirror 32, and the line sensor 61. To reach.
  • the focus determination circuit 101 outputs a focus signal corresponding to the distance between the peak V of the intensity distribution shown in FIG. 11 and the center address Q of the line sensor 61 based on the amount of light received by each light receiving element of the line sensor 61. To do.
  • the control device 104 displays the marks 15S, 15P, and 15Ma on the display unit 310 based on the focus signal as shown in FIG.
  • the separation distance between the mark 15P and the mark 15Ma corresponds to the separation distance between the peak V of the intensity distribution and the center address Q of the line sensor 61 shown in FIG.
  • the examiner moves the apparatus main body so as to match the mark 15P with the mark 15Ma while looking at the display unit 310.
  • control device 104 controls the driver D3 based on the focus signal to drive the Z motor 203, and the device main body 303 so that the peak V coincides with the center address Q of the line sensor 61. Move back and forth.
  • the control device 104 stops the Z motor 203.
  • the reflected light beams R1, R2, and R3 transmitted through the half mirror 32 are guided to the mask plate 130 via the mirror 34 and the relay lens 35.
  • the mask plate 130 is arranged so that only the reflected light beam R2 is transmitted.
  • the reflected light beam R2 that has passed through the mask plate 130 passes through the relay lens 132, is reflected by the mirror 36, reaches the CCD 17, and an optical image is formed on the CCD 17 by the reflected light beam R2. That is, a corneal endothelium image is formed, and as shown in FIG. 12, the corneal endothelial cell image J is displayed on the screen 18 of the display unit 310, and the imaging light source 25 is emitted to perform imaging. That is, corneal endothelial cells in the central part of the cornea C are photographed.
  • one of the light emitting diodes 74a to 74h corresponding to the predetermined part is caused to emit light, and XY alignment or Z alignment is performed in the same manner as described above to photograph the part. .
  • the outer peripheral photographing mode for photographing the peripheral part of the cornea C is set, after the photographing is performed, the light emission of the observation light source 21 is stopped, and the light shielding plate 16 is retracted from the optical path. 131 is inserted into the optical path.
  • the external peripheral photographing mode is entered and any one of the external fixation target light sources 321 to 326 emits light.
  • the apparatus main body 303 is retracted by a predetermined distance with respect to the base portion 302. That is, the apparatus main body 303 moves backward by a predetermined distance with respect to the eye E.
  • one of the external fixation target light sources 321 to 326 emits light. Since the apparatus main body 303 is moved backward with respect to the eye E, the subject can easily see the external fixation target light sources 321 to 326 that are emitting light, and the line of sight is externally fixed target light source 321. To 326. For this reason, it is possible to promptly guide the subject's line of sight from the internal fixation target to the external fixation target.
  • the light emitted from the external fixation target light sources 321 to 326 may be blinking, or may be blinked for an initial predetermined time and then continuously emitted.
  • the alignment index light source 41 is caused to emit light, and XY alignment is performed in the same manner as described above.
  • XY alignment is completed, light emission of the alignment index light source 41 is stopped and infrared light is emitted from the observation light source 21.
  • the light shielding plate 16 is inserted into the optical path, and the light shielding plate 131 is detached from the optical path.
  • the apparatus main body 303 may be retracted to guide the subject's line of sight to the external fixation target.
  • the external fixation target light sources 321 to 326 may be used by the subject. Since the external fixation target light sources 321 to 326 may emit light without guiding the apparatus main body 303 backward, the line of sight of the subject may be guided.
  • the apparatus main body 303 when guiding the line of sight to the external fixation target light sources 321 to 326, the apparatus main body 303 is retracted, but from the state where the light is fixed to any one of the light emitting diodes 71 to 73, the internal peripheral fixation light source is shifted.
  • the apparatus main body 303 may be moved backward when guiding the line of sight to the light emitting diodes 74a to 74h for viewing.

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  • Life Sciences & Earth Sciences (AREA)
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Abstract

L'invention concerne un dispositif de capture d'image de cellules endothéliales cornéennes (100) comprenant ce qui suit : un système optique pour émettre de la lumière à partir d'une lampe à fente ; un système optique de capture d'image de cellules endothéliales cornéennes pour capturer des images de cellules endothéliales cornéennes ; une cible de fixation interne et une cible de fixation externe pour faire tourner un œil sous test dans un sens spécifique ; un moyen de détection d'alignement pour détecter l'alignement d'un corps principal de dispositif par rapport à l'œil sous test ; et un corps principal de dispositif (303) au niveau duquel est disposé le système optique d'émission de lumière à partir d'une lampe à fente, le système optique de capture d'image de cellules endothéliales cornéennes, la cible de fixation interne et la cible de fixation externe, et le moyen de détection d'alignement. Le corps principal de dispositif (303) peut se déplacer vers l'avant et vers l'arrière, vers la gauche et vers la droite, et vers le haut et vers le bas par rapport à l'œil sous test. Le corps principal du dispositif (303) est temporairement rétracté lors de la capture d'une image de cellules endothéliales cornéennes par l'éclairage des cibles de fixation externe (321-326) après que le moyen de détection d'alignement ait détecté que l'alignement est achevé, et faisant alors tourner l'œil sous test vers la cible de fixation externe.
PCT/JP2014/064423 2013-06-12 2014-05-30 Dispositif de capture d'image de cellules endothéliales cornéennes WO2014199847A1 (fr)

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JP2013-123707 2013-06-12
JP2013123707A JP6224923B2 (ja) 2013-06-12 2013-06-12 角膜内皮細胞撮影装置

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CN106821304B (zh) * 2017-03-07 2018-09-25 林广杰 一种多功能眼科用眼部疾病检查装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0994230A (ja) * 1995-09-29 1997-04-08 Topcon Corp 眼科装置
JP2004033377A (ja) * 2002-07-02 2004-02-05 Kowa Co 眼科検査装置
JP2013059565A (ja) * 2011-09-14 2013-04-04 Nidek Co Ltd 角膜内皮細胞撮影装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0994230A (ja) * 1995-09-29 1997-04-08 Topcon Corp 眼科装置
JP2004033377A (ja) * 2002-07-02 2004-02-05 Kowa Co 眼科検査装置
JP2013059565A (ja) * 2011-09-14 2013-04-04 Nidek Co Ltd 角膜内皮細胞撮影装置

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