WO2014082488A1 - 试剂装载方法、系统及生化分析仪 - Google Patents

试剂装载方法、系统及生化分析仪 Download PDF

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Publication number
WO2014082488A1
WO2014082488A1 PCT/CN2013/084037 CN2013084037W WO2014082488A1 WO 2014082488 A1 WO2014082488 A1 WO 2014082488A1 CN 2013084037 W CN2013084037 W CN 2013084037W WO 2014082488 A1 WO2014082488 A1 WO 2014082488A1
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WIPO (PCT)
Prior art keywords
reagent
test
trigger signal
instrument
needle
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PCT/CN2013/084037
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English (en)
French (fr)
Inventor
王霞
陈大凯
刘辉
Original Assignee
深圳迈瑞生物医疗电子股份有限公司
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Priority claimed from CN201210499038.9A external-priority patent/CN103675302B/zh
Application filed by 深圳迈瑞生物医疗电子股份有限公司 filed Critical 深圳迈瑞生物医疗电子股份有限公司
Publication of WO2014082488A1 publication Critical patent/WO2014082488A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00613—Quality control
    • G01N35/00663—Quality control of consumables
    • G01N2035/00673—Quality control of consumables of reagents

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  • the present application relates to an automatic biochemical analyzer, and more particularly to a reagent loading method, system and biochemical analyzer.
  • the reagent loading operation can be performed when the software prompts that the reagent loading can be performed, and the waiting time is related to the current test state of the instrument. This operation requires the operator to apply and wait before loading, the process is more complicated, greatly increasing the time for the operator to load the online reagent.
  • reagent loading is required only when the reagent loading conditions are met. If the operator forcibly opens the reagent tray cover refilling reagent during the testing process if the reagent loading conditions are not met, a safety accident may occur. For example, causing the reagent needle to collide with other devices, or the running device hits the operator.
  • the problem to be solved by the present application is to propose a reagent loading method, system and automatic biochemical analyzer, which is convenient for the operator to safely load the reagent during the testing process.
  • a reagent loading method comprising:
  • the processing and control unit receives the first trigger signal, and sends an instrument protection command according to the first trigger signal, where the instrument protection command is used to control the reagent disk corresponding to the first trigger signal to stop rotating, and control the reagent adding mechanism to drive The reagent needle corresponding to the reagent disk is stopped to a safe position, and the instrument is brought into a state in which the reagent can be loaded.
  • a reagent loading system comprising:
  • a reagent loading mechanism comprising a reagent tray for carrying a reagent container, being rotatable by a driving device, and a reagent tray cover covering the reagent tray;
  • a reagent disk cover monitoring device for generating a first trigger signal indicating that the reagent disk cover is open
  • a reagent adding mechanism for taking the reagent from the reagent tray and filling it into the reaction cup
  • a processing and control unit for receiving a first trigger signal, the processing and control unit comprising an instrument management module and a reagent management module, the instrument management module for issuing an instrument protection command according to the first trigger signal, the instrument protection The command is configured to control the reagent tray corresponding to the first trigger signal to stop rotating, and control the reagent adding mechanism to drive the reagent needle corresponding to the reagent tray to stop to a safe position, and the reagent management module is configured to enter the loadable reagent according to the first trigger signal status.
  • an automatic biochemical analyzer comprising a reagent loading system as described above.
  • the instrument protection command is issued according to the opening information of the reagent tray cover, the reagent tray and the reagent needle are in a safe state, and the user does not need a large amount of human-computer interaction and waiting in the machine, and directly opens the reagent tray cover to load the reagent, and does not need Worried about safety issues, the operation is simple and convenient, and the reagent loading during the test can be quickly performed, thereby improving work efficiency.
  • FIG. 1 is a schematic diagram of a module of a reagent loading system in an embodiment of the present application
  • FIG. 2 is a schematic flow chart of a reagent loading method in the first embodiment
  • FIG. 3 is a schematic flow chart of a control reagent needle stopped to a safe position in the first embodiment
  • Figure 5 is a schematic view showing the movement of the reagent needle to a safe position in the first embodiment
  • FIG. 6 is a flow chart of test management in a reagent loading method according to Embodiment 2 of the present application.
  • FIG. 7 is a flow chart of an automatic start test in a reagent loading method according to Embodiment 3 of the present application.
  • the biochemical analyzer mainly includes a reaction disc mechanism, a sample loading mechanism, a reagent loading mechanism, a sample loading mechanism, a reagent adding mechanism, and a main control system.
  • the master control system is used to manage, calculate and/or analyze test results and provide human-computer interaction interfaces, including processing and control units.
  • the reaction tray mechanism includes a reaction tray for carrying the reaction cup, and the sample loading mechanism is for providing the sample to be tested, including the sample tray or the sample transport rack, and the sample loading mechanism is sampled from the sample tray or the sample transport rack according to the management of the main control system. The sample is sucked into the cup and filled into the reaction cup.
  • the reagent loading mechanism is used to provide a reagent for the reaction, usually including a reagent tray, and the reagent adding mechanism absorbs the reagent from the reagent container on the reagent tray according to the management of the main control system, and The reagent is filled into the cuvette.
  • the reagent loading system 400 includes a reagent tray cover monitoring device 410 , a reagent loading mechanism 420 , and a reagent for sucking the reagent from the reagent tray and filling the reagent into the reagent tray.
  • the reagent adding mechanism 440 in the reaction cup, the processing and control unit 430, the reagent loading mechanism 420 includes a reagent disk and a reagent disk cover (not shown) covering the reagent disk, and the reagent disk can be rotated by the driving device. .
  • the reagent tray cover monitoring device is configured to generate a signal indicating that the reagent disk cover is open when the reagent disk is opened during the test or when the reagent disk is to be opened, and when the processing and control unit 430 receives the signal, corresponding processing is performed to enable the reagent to be completed. Load online.
  • the processing and control unit 430 includes an instrument management module 431, a test management module 433, a test module 432, and a reagent management module 435.
  • the instrument management module 431 detects the action or state of each component of the instrument, including the opening or closing information of the reagent disk cover, and performs corresponding instrument actions to support reagent loading or testing.
  • the reagent management module 435 is used to collect reagent information and manage reagent information, and in some embodiments may also prompt the user to perform reagent loading.
  • the test management module 433 is configured to manage the tests that need to be performed, generate test information, including invalidation of tests that cannot be continued, and automatically perform retests.
  • the test module 432 is configured to perform testing according to the test information of the test management module.
  • the reagent disk cover monitoring device 410 generates a first trigger signal indicating that the reagent disk cover is open, and the instrument management module 431 issues an instrument protection command according to the first trigger signal, and the instrument protection command is used to control the first trigger signal.
  • the corresponding reagent tray stops rotating, and the control reagent adding mechanism 440 drives the reagent needle corresponding to the reagent tray to stop to a safe position, and the reagent management module 435 is configured to enter the state of the loadable reagent according to the first trigger signal, and the state of the loadable reagent is
  • the status of the reagent raw information is allowed to be updated, and the reagent raw information includes, for example, the location of the reagent, the batch number, the item, and the like.
  • the test management module 433 determines, according to the first trigger signal, a test item that can be continued and a test item that needs to be invalidated, and the test item that can be continued is that the reagent disk corresponding to the first trigger signal is completed. For the test item with reagent addition, the test item that needs to be invalidated is the test item for adding reagent to the reagent plate. The test management module 433 generates test information based on the determination result.
  • the test module 432 performs testing according to the test information generated by the test management module 433, for example, generating a test control signal or generating a test calculation result, and the test control signal can be used to control the sample loading mechanism to perform the sample loading operation, the reagent adding mechanism to perform the reagent adding operation, and the like.
  • the reagent disk cover monitoring device 410 is further configured to generate a second trigger signal indicating that the reagent disk cover is closed, and the instrument management module 431 confirms that the reagent disk cover corresponding to the second trigger signal is closed according to the second trigger signal. , to check whether all the reagent tray covers are currently closed, and if so, start the instrument recovery process.
  • the instrument recovery process consists of restoring the reagent tray and reagent addition mechanism to the initial position and preparing to start a new test in accordance with the normal test procedure.
  • the instrument management module When the instrument recovery process is complete, the instrument management module generates a notification to start a new test.
  • the test management module 433 automatically restarts the test according to the notification of starting the new test, and generates the test information according to the test sequence by the new test item that needs to be tested and the retest item that needs to be retested after being invalidated.
  • the test module 432 performs testing based on the test information generated by the test management module 433.
  • processing and control unit further includes a system setting module for setting whether to perform a reagent pause after opening the reagent tray cover.
  • Embodiment 1 is a diagrammatic representation of Embodiment 1:
  • a reagent loading method in this embodiment includes the following steps:
  • S11 Generate a first trigger signal indicating that the reagent tray cover is open.
  • There may be one or more reagent trays.
  • the reagent tray cover may also have one or more.
  • the operator may open any reagent tray cover according to the needs of the supplementary reagent.
  • the reagent tray cover monitoring device 410 When a reagent tray cover is open or is about to open, the reagent tray cover monitoring device 410 generates a first trigger signal indicating that the reagent tray cover is open.
  • the reagent disk cover monitoring device 410 may be a sensor disposed on the reagent disk or the reagent disk cover for sensing the opening and closing of the reagent disk cover.
  • the sensor information changes, and the output is changed.
  • Different signals when the reagent tray cover is open, the sensor outputs a first trigger signal.
  • the sensor for sensing the opening and closing of the reagent disc cover can employ any sensor that has been or will appear in the future to enable opening and closing of the sensing reagent disc cover.
  • the reagent tray lid monitoring device 410 can also be a button coupled to the processing and control unit, the button being positionable anywhere in the biochemical analyzer, preferably at a location convenient for user operation. When the user presses the button, it indicates that the reagent tray cover is open or is opening or about to open.
  • the reagent tray cover monitoring device 410 can also be a human-computer interaction interface. The user can input a command by clicking an option to generate a first trigger signal through an option set on the human-machine interaction interface.
  • the generation of the first trigger signal may be generated when the user feels that the reagent needs to be replenished by the user opening the reagent tray cover, or may be generated by triggering a button or clicking an option on the human-machine interface.
  • the first trigger signal can also be generated by the reagent management module 435 displaying the reagent information, prompting the user to perform the reagent loading, and the user determines that the reagent needs to be supplemented according to the reminder, and then the user opens the reagent tray cover, triggers the button, or clicks on the human-computer interaction interface.
  • the first trigger signal is generated by the above option. Therefore, when the first trigger signal is generated, the reagent tray cover may be opening or may be already open or about to open.
  • the processing and control unit receives the first trigger signal, and the instrument management module issues an instrument protection command according to the first trigger signal, and performs the following control according to the instrument protection command.
  • S132 Control the reagent needle corresponding to the reagent disc to stop to a safe position.
  • the reagent adding mechanism drives the reagent needle to a safe position according to the instrument protection command.
  • the safe position may be any position that does not prevent the reagent disk from opening and loading the reagent, for example, a position that is a certain height away from the reagent disk in the vertical direction, or a distance away from the reagent disk in the horizontal direction.
  • the safe position may be a position where the reagent needle first rises vertically and then horizontally rotates away from the reagent disk a certain distance, for example, where the reagent needle is located when the instrument is stopped.
  • S133 Controls the state of the instrument into the loadable reagent.
  • the biochemical analyzer is brought into a state in which the reagent can be loaded according to the first trigger signal, in which state the reagent raw information can be allowed to be updated.
  • the reagent raw information may be input by the operator through the human-computer interaction interface according to the manner of updating the original information of the reagent, or the original information of the reagent may be scanned by the scanner by scanning the barcode of the newly loaded reagent container. Input.
  • the processing and control unit issues an instrument protection command in response to the first trigger signal to perform safety protection, including safety of the instrument and safety of the operator.
  • the reagent tray does not rotate when the reagent tray cover is opened. This prevents damage to the reagent container or collision with the operator. Stopping the reagent needle to a safe position prevents the instrument from colliding with the operator and leaving room for the operator to load the reagent.
  • the safety protection control commands for the reagent tray and the reagent needle can be issued simultaneously or sequentially.
  • the timing of the above steps S132 and S133 can be reversed.
  • step S132 different strategies are adopted according to different situations, including the following specific steps:
  • step S140 It is detected whether the reagent needle corresponding to the reagent tray is at a safe position. If not, the process goes to step S141, and if yes, the process goes to step S142.
  • S141 Control the reagent adding mechanism to drive the reagent needle to rise to the vertical initial position, and then horizontally rotate to a safe position.
  • the vertical initial position during this process is the position at which the reagent needle is lifted away from the reagent tray and does not affect the horizontal rotation of the reagent needle.
  • FIG. 5 is a schematic view showing the movement of the reagent needle to a safe position in a specific embodiment.
  • the schematic diagram shows the reagent tray 101, the reagent needle 102 corresponding to the reagent tray 101, the movement track 103 of the reagent needle 102, and the reagent.
  • the horizontal initial position is the position of the reagent needle when the instrument is stopped.
  • the reagent needle 102 When it is detected that the reagent disk cover 1 (not shown in the figure) on the reagent disk 101 is opened, the reagent needle 102 is located at the reagent disk 101 and the horizontal initial position 104 (the reagent needle 102 stays after the normal reagent addition operation). Between the positions, the control reagent adding mechanism drives the reagent needle 102 to first rise to the vertical initial position, and then horizontally rotates to the horizontal initial position 104, otherwise it returns to the horizontal initial position 104 after completing the action according to the normal flow.
  • the reagent needle 202 is located at the reagent tray 201 and the horizontal initial position 204 (the position where the reagent needle 202 stays after the normal reagent addition operation is completed). Alternatively, the same can be run to or near the horizontal initial position 204, or can be run to the extreme position 205 (the mechanical structure determines the farthest position at which the reagent needle 202 can rotate clockwise). Otherwise, it returns to the initial position 204 after completing the action according to the normal flow.
  • the horizontal initial position 104 in this step is the safe position of the reagent needle 102, and the horizontal initial position 204 or extreme position 205 is the safe position of the reagent needle 202.
  • the reagent adding mechanism may collide with other objects.
  • the anti-collision sensor is installed on the reagent adding mechanism, and the anti-collision sensor is generated when the reagent adding mechanism collides with other objects during the movement.
  • the collision signal may also include anti-collision protection during the process of controlling the reagent needle to move to a safe position. Referring to FIG. 4, the following steps are specifically included:
  • step S15 detecting whether the reagent adding mechanism generates the first collision signal during the movement, if yes, proceeding to step S16, and if no, proceeding to step S140 to detect whether the reagent needle corresponding to the reagent tray is in a safe position.
  • the collision sensor is installed on the reagent adding mechanism. When the reagent adding mechanism collides with other objects in the moving process, the collision sensor generates a collision signal, and the processing and control unit receives the collision signal, and the instrument management The module processes according to the first collision signal.
  • step S16 Control the reagent adding mechanism to drive the reagent needle to reduce the moving speed.
  • the moving speed of the collision avoidance process is slower than the moving speed in step S141 to prevent excessive movement from damaging the reagent needle or other parts of the reagent adding mechanism.
  • step S17 Whether the detection reagent needle generates the second collision signal during the movement of the step S16, if yes, the process goes to step S18, and if no, the process goes to step S140 to detect whether the reagent needle corresponding to the reagent disk is in the safe position.
  • the control reagent adding mechanism drives the reagent needle to stay at the current position and no longer moves, and the instrument completes the test that is not affected by the opening of the reagent disc cover, and then enters the stop state, thereby protecting the instrument.
  • the anti-collision protection may also be when the first collision signal is detected, that is, the control reagent adding mechanism stops the reagent needle from staying at the current position and no longer moves.
  • the protection of the reagent disk and the reagent needle is adopted.
  • other protection methods may be adopted, for example, only the reagent disk stall protection or the protection of all moving parts of the system, that is, All moving parts return to their original position.
  • Embodiment 2 is a diagrammatic representation of Embodiment 1:
  • the processing and control unit not only issues an instrument protection command according to the first trigger signal indicating that the reagent disk is turned on, but also tests the required test according to the first trigger signal. management.
  • the reagent disk opening information received by the test management module may be directly the first trigger signal or the first trigger signal that is forwarded or processed by the instrument management module. Please refer to Figure 6, the specific steps of test management are as follows:
  • S21 Generate a first trigger signal indicating that the reagent tray cover is open.
  • the processing and control unit receives the first trigger signal, and the test management module performs test management on the test that needs to be performed according to the first trigger signal.
  • test management module judges the influence of the execution of the protection command on the started test during the opening process of the reagent disk cover according to the current test, and divides the items that have started the test into two types, and the test items that can be continued and the tests that need to be invalidated. project.
  • the test items that can be continued are the test items for completing the reagent addition test of the corresponding reagent disk, and the test items not affected by the opening of the reagent disk cover; the test items that need to be invalidated are the tests of the reagents that have not completed the corresponding reagent disk and are interrupted. Test. If it is a test item that continues, go to step S24, if it is a test item that needs to be invalidated, go to step S25.
  • test module continues to test the test items that can be continued, and the test results are given after the test ends.
  • test management module performs the invalidation of the test item that needs to be invalidated, and does not continue to execute.
  • the test management module generates a retested test item that needs to be retested, and retests when the test is started again.
  • the test items that have been started are classified and managed, so that the test items that are not affected by the opening of the reagent disk cover can continue to be tested, and the affected test items are invalidated, and the test items are not continued. Test to avoid erroneous results.
  • the test can be carried out in an orderly manner after the reagent disk cover is directly opened.
  • Embodiment 3 is a diagrammatic representation of Embodiment 3
  • the reagent tray cover is closed and the user can restart the test by manually starting the instrument.
  • This embodiment is based on the first or second embodiment, after the reagent tray cover is closed, the instrument is automatically started and the test is restarted.
  • the method for automatically starting the instrument includes the following steps:
  • S31 Generate a second trigger signal indicating that the reagent tray cover is closed.
  • the reagent tray cover monitoring device 410 When the reagent is loaded, when the reagent tray cover is closed or is about to close, the reagent tray cover monitoring device 410 generates a second trigger signal indicating that the reagent tray cover is closed. Taking the reagent disk cover monitoring device 410 as a sensor disposed on the reagent disk or the reagent disk cover for sensing the opening and closing of the reagent disk cover, when the reagent disk cover is closed, the sensor information changes, and a second trigger signal is output.
  • the processing and control unit receives the second trigger signal, and the instrument management module performs a confirmation operation according to the reagent disk corresponding to the second trigger signal, and the confirming operation may include confirming whether the corresponding reagent information of the current reagent disk has been updated, and may also include confirming Whether the reagent tray cover corresponding to the second trigger signal has been turned off, if not updated, updating according to the collected reagent information, for example, prompting the operator to input the reagent original information, or controlling the scanner to scan the newly loaded reagent container.
  • step S33 the instrument management module detects whether all the reagent disk covers are currently in the closed state, and if so, then proceeds to step S341, and if not, proceeds to step S342;
  • step S341 The instrument management module starts the instrument recovery process. When the instrument management module checks that all reagent tray covers have been closed, the instrument recovery process is initiated, the reagent tray and reagent loading unit are restored to their original positions, and new tests are initiated to begin the normal test procedure. After the recovery is completed, step S35 is performed;
  • step S342 continue to wait for the second trigger signal corresponding to the unclosed reagent disk cover, and then go to step S33; in this step, when the processing and control unit receives the second trigger signal corresponding to the unclosed reagent disk cover, then return In step S33, it is detected again whether all the reagent tray covers are in the closed state. If the reagent tray is not closed, step S342 is performed, and the operation is continued until it is confirmed that all the reagent tray covers have been closed, and then the process proceeds to step S341.
  • the instrument management module generates a notification to start a new test and sends the notification to the test management module.
  • the test management module automatically restarts the test according to the notification of starting the new test, manages the new test that needs to be started, and needs to perform the retest test because the reagent disk is opened, and the test to be performed is sorted according to the test sequence, and the test will be required.
  • the new test project and the retest project generate test information in the test order.
  • test module tests according to the test information given by the test management module, according to the test flow, and finally gives the test results of all the tests.
  • the instrument management module may not detect whether all the reagent disk covers are in the closed state, for example, The process may be: first generating a second trigger signal indicating that the reagent tray cover is closed, the processing and control unit receiving the second trigger signal, and the instrument management module starts the instrument recovery process according to the second trigger signal, and after the recovery is completed, a new test is started. The notification is sent to the test management module, and the test management module automatically restarts the test based on the notification to start the new test.
  • the above embodiments are applicable to a single reagent disk or a plurality of reagent disks, and are not subject to the number of reagent disks.
  • all the reagent discs and the corresponding reagent adding mechanism can be controlled to return to the initial position or the extreme position to ensure the safety of the personnel and the instrument, and all the reagent trays support the online loading of the reagent. .
  • the instrument enters a state where reagent loading is possible, but all tests that are in progress are stopped.
  • the reagent tray cover is opened and the reagent tray cover is closed.
  • various recovery methods can be selected, such as only recovering the reagent needle, the reagent tray unit, or restoring the reagent needle, the reagent tray, the sample needle unit, and the like.
  • the reagent tray cover is opened and the reagent tray cover is closed.
  • the test is turned off during the opening of the disk cover, and the automatic retest is no longer performed, and only the new test is started.

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Abstract

一种试剂装载方法、系统及生化分析仪，所述方法包括：产生表示试剂盘盖打开的第一触发信号，处理和控制单元接收第一触发信号，根据第一触发信号发出仪器保护命令，该保护命令用于控制与第一触发信号对应的试剂盘停止转动，控制加试剂机构带动与所述试剂盘对应的试剂针停止到安全位置，并控制仪器进入可装载试剂的状态。所述试剂装载系统（400）包括：试剂装载机构（420），试剂盘盖监测装置（410），加试剂机构（440）以及处理和控制单元（430）。所述生化分析仪包括上述试剂装载系统。试剂装载时，试剂装载系统发出的仪器保护命令可使用户安全操作，无需大量人机交互和等待，提高了工作效率。

Description

试剂装载方法、系统及生化分析仪 技术领域
本申请涉及一种全自动生化分析仪，尤其涉及一种试剂装载方法、系统及生化分析仪。
 背景技术
目前，随着生化仪的广泛应用和样本量的不断增加，对于生化仪高速、简单易用、自动化程度的要求也越来越高，以此来减少操作人员的工作量，提高工作效率。
在使用生化仪过程中，由于样本量不断增大，需要及时的进行试剂补充以满足测试需要。目前主要有两种试剂装载方式：
1、在测试前后补充试剂，测试过程中不补充试剂。当测试过程中试剂不足时，需要等待测试完成后再添加试剂，并且未完成对应试剂盘加试剂的测试需要进行重测，因此延长了工作时间，增加了操作人员的工作量。
2、在测试过程中补充试剂。操作人员需要在软件上进行加试剂暂停申请，并关注软件提示信息，在软件提示可以执行试剂装载时才可进行试剂装载操作，其中等待时间长短与仪器当前的测试状态相关。该操作要求操作人员先进行申请再等待而后才可装载，流程比较复杂，大大增加了操作人员进行在线试剂装载的时间。
对于这两种试剂装载方式，都需要满足试剂装载条件时才可进行试剂装载，如果在试剂装载条件不满足的情况下操作者强行在测试过程中打开试剂盘盖补充试剂，则可能发生安全事故，例如导致试剂针与其它装置发生碰撞，或运行中的设备碰到操作人员。
 发明内容
本申请要解决的问题是，提出一种试剂装载方法、系统及全自动生化分析仪，便于操作人员在测试过程中安全的装载试剂。
根据本申请的第一方面，提出一种试剂装载方法，包括：
产生表示试剂盘盖打开的第一触发信号；
处理和控制单元接收所述第一触发信号，根据所述第一触发信号发出仪器保护命令，所述仪器保护命令用于控制与第一触发信号对应的试剂盘停止转动，和控制加试剂机构带动与所述试剂盘对应的试剂针停止到安全位置，使仪器进入可装载试剂的状态。
根据本申请的第二方面，提出一种试剂装载系统，包括：
试剂装载机构，其包括用于承载试剂容器、在驱动装置的带动下可转动的试剂盘，和覆盖在试剂盘上的试剂盘盖；
试剂盘盖监测装置，其用于产生表示试剂盘盖打开的第一触发信号；
加试剂机构，用于从试剂盘吸取试剂并加注到反应杯中；
处理和控制单元，其用于接收第一触发信号，所述处理和控制单元包括仪器管理模块和试剂管理模块，所述仪器管理模块用于根据第一触发信号发出仪器保护命令，所述仪器保护命令用于控制与第一触发信号对应的试剂盘停止转动，和控制加试剂机构带动与所述试剂盘对应的试剂针停止到安全位置，试剂管理模块用于根据第一触发信号进入可装载试剂的状态。
根据本申请的第三方面，提供一种全自动生化分析仪，所述分析仪包括如上所述的试剂装载系统。
本申请由于根据试剂盘盖的开启信息发出了仪器保护命令，使得试剂盘和试剂针处于安全状态，用户不需要大量人机交互及在机等待，直接打开试剂盘盖即可装载试剂，不需要担心安全问题，操作简单方便，可以快速进行测试过程中的试剂装载，因此提高了工作效率。
附图说明
图1为本申请一种实施例中试剂装载系统的模块示意图；
图2为实施例一中一种试剂装载方法的流程示意图；
图3为实施例一中一种控制试剂针停止到安全位置的流程示意图；
图4为实施例一中防撞保护的流程示意图；
图5为实施例一中试剂针移动到安全位置的示意图；
图6为本申请实施例二中一种试剂装载方法中测试管理的流程图；
图7为本申请实施例三中一种试剂装载方法中自动启动测试的流程图。
具体实施方式
生化分析仪主要包括反应盘机构、样本装载机构、试剂装载机构、加样机构、加试剂机构以及主控系统。主控系统用于对测试进行管理、计算和/或分析测试结果和提供人机交互界面等，包括处理和控制单元。反应盘机构包括用于承载反应杯的反应盘，样本装载机构用于提供被测试样本，包括样本盘或样本传送架，加样机构按照主控系统的管理从样本盘或样本传送架上的样本杯中吸取样本，并加注到反应杯内，试剂装载机构用于提供反应用试剂，通常包括试剂盘，加试剂机构按照主控系统的管理从试剂盘上的试剂容器中吸取试剂，并将试剂加注到反应杯内。
当试剂不足时，需要进行试剂加载，本申请实施例中，如图1所示，试剂装载系统400包括试剂盘盖监测装置410、试剂装载机构420、用于从试剂盘吸取试剂并加注到反应杯中的加试剂机构440、处理和控制单元430，试剂装载机构420包括试剂盘和覆盖在试剂盘上的试剂盘盖（图中未示出），试剂盘在驱动装置的带动下可转动。在测试过程中，试剂盘盖为闭合状态，试剂盘在驱动装置的带动下将预定的试剂容器转动到吸试剂位，加试剂机构同时也带动试剂针转动，完成加试剂操作。试剂盘盖监测装置用于在测试过程中打开试剂盘或将要打开试剂盘时产生表示试剂盘盖打开的信号，处理和控制单元430接收到该信号时，进行相应处理，以使得能够完成试剂的在线装载。在一种具体实例中，处理和控制单元430包括仪器管理模块431、测试管理模块433、测试模块432和试剂管理模块435。仪器管理模块431探测仪器各部件的动作或状态，包括试剂盘盖打开或关闭信息，并执行相应仪器动作，支持试剂装载或者测试。试剂管理模块435用于采集试剂信息和管理试剂信息，在有些具体实例中还可以提醒用户进行试剂装载。测试管理模块433用于对需要进行的测试进行管理，生成测试信息，包括作废不能继续进行的测试，自动进行重新测试。测试模块432用于按照测试管理模块的测试信息进行测试。
在一种具体实例中，试剂盘盖监测装置410产生表示试剂盘盖打开的第一触发信号，仪器管理模块431根据第一触发信号发出仪器保护命令，仪器保护命令用于控制与第一触发信号对应的试剂盘停止转动，和控制加试剂机构440带动与试剂盘对应的试剂针停止到安全位置，试剂管理模块435用于根据第一触发信号进入可装载试剂的状态，可装载试剂的状态为允许更新试剂原始信息的状态，试剂原始信息例如包括试剂的位置、批号、项目等信息。
在另一种实施例中，测试管理模块433根据第一触发信号判断可继续进行的测试项目和需要作废的测试项目，可继续进行的测试项目为已完成与第一触发信号对应的试剂盘的加试剂的测试项目，需要作废的测试项目为未完成该试剂盘的加试剂的测试项目。测试管理模块433根据判断结果生成测试信息。测试模块432根据测试管理模块433生成的测试信息进行测试，例如生成测试控制信号或生成测试计算结果，测试控制信号可用于控制加样机构执行加样操作、加试剂机构执行加试剂操作等。
在又一实施例中，试剂盘盖监测装置410还用于产生表示试剂盘盖关闭的第二触发信号，仪器管理模块431根据第二触发信号确认与第二触发信号对应的试剂盘盖已经关闭，检测当前所有试剂盘盘盖是否均已经处于关闭状态，如果是则启动仪器恢复流程。仪器恢复流程包括：将试剂盘和加试剂机构恢复到初始位置，准备开始按照正常测试流程启动新的测试。当仪器恢复流程完成后仪器管理模块产生开始新测试的通知。测试管理模块433根据开始新测试的通知自动重启测试，将需要进行测试的新测试项目和作废后需要重新测试的重测项目按照测试顺序生成测试信息。测试模块432根据测试管理模块433生成的测试信息进行测试。
在另外的具体实例中，处理和控制单元还包括系统设置模块，系统设置模块用于设置是否打开试剂盘盖后执行试剂暂停。
下面通过具体实施方式结合附图对试剂在线装载的方法作进一步详细说明。
实施例一：
请参考图2，本实施例中一种试剂装载方法包括以下步骤：
S11：产生表示试剂盘盖打开的第一触发信号。试剂盘可以有一个或多个，相应的，试剂盘盖也可以有一个或多个，在测试过程，操作者根据补充试剂的需要，有可能打开任意个试剂盘盖。当某个试剂盘盖打开或将要打开时，试剂盘盖监测装置410产生第一触发信号，第一触发信号用于表示试剂盘盖被打开。
在一种具体实例中，试剂盘盖监测装置410可以是设置在试剂盘或试剂盘盖上用于感知试剂盘盖开合的传感器，当试剂盘盖打开或闭合时，传感器信息发生变化，输出不同的信号，当试剂盘盖打开时，传感器输出第一触发信号。用于感知试剂盘盖开合的传感器可采用已有或将来出现的可实现感知试剂盘盖开合的任一传感器。在另一种具体实例中，试剂盘盖监测装置410还可以是与处理和控制单元连接的按钮，按钮可设置在生化分析仪的任意位置，优选设置在方便用户操作的位置。当用户按下该按钮时，表示试剂盘盖已打开或正在打开或即将打开。在又一种具体实例中，试剂盘盖监测装置410还可以是人机交互界面，用户通过人机交互界面上设置的选项，通过点击选项可输入命令，产生第一触发信号。
第一触发信号的产生可以是在用户感觉需要补充试剂时由用户打开试剂盘盖时产生，也可以通过触发按钮或点击人机交互界面上的选项而产生。第一触发信号也可以通过以下方式产生：试剂管理模块435显示试剂信息，提醒用户进行试剂装载，用户根据该提醒确定需要补充试剂，然后用户通过打开试剂盘盖、触发按钮或点击人机交互界面上的选项而触发第一触发信号产生。因此，第一触发信号产生时，试剂盘盖可能正在打开，也可能已经打开或即将打开。
S12：处理和控制单元接收第一触发信号，仪器管理模块根据第一触发信号发出仪器保护命令，并根据仪器保护命令执行以下控制。
S131：控制与第一触发信号对应的试剂盘停止转动，试剂装载机构响应该控制命令，驱动装置控制试剂盘停止转动。
S132：控制该试剂盘对应的试剂针停止到安全位置。加试剂机构根据仪器保护命令带动试剂针停止到安全位置。
安全位置可以是不妨碍试剂盘打开和加载试剂的任一位置，例如，在垂直方向上离开试剂盘有一定高度的位置，或在水平方向上离开试剂盘有一定距离的位置。在一具体实例中，安全位置可以是试剂针先垂直上升再水平旋转以离开试剂盘一定距离的位置，例如，仪器停止时试剂针所处的位置。
S133：控制仪器进入可装载试剂的状态。例如，根据第一触发信号使生化分析仪进入可装载试剂的状态，在该状态，可允许试剂原始信息被更新。当操作人员装载完试剂后，根据试剂原始信息更新方式的不同，可由操作人员通过人机交互界面将试剂原始信息输入，也可以由扫描仪通过扫描新装载的试剂容器的条码而将试剂原始信息输入。本实施例中，处理和控制单元通过响应第一触发信号而发出仪器保护命令，从而进行安全保护，安全保护包括仪器的安全和操作人员的安全。试剂盘在试剂盘盖被打开时不再转动，这样可预防损坏试剂容器或碰撞操作人员，试剂针停止到安全位置可预防仪器碰撞操作人员，并为操作人员装载试剂留出操作空间。
对试剂盘和试剂针的安全保护控制命令可以同时发出也可相继发出。上述步骤S132和S133的时序可以进行调换。
在试剂测试过程中，与试剂盘对应的试剂针在试剂盘和反应盘之间运动，当试剂盘盖打开时，相应的试剂针可能位于安全位置，也可能偏离了安全位置。因此在另一具体实例中，请参考图3，在步骤S132根据不同的情况采用不同策略，包括以下具体步骤：
S140，检测与试剂盘对应的试剂针是否位于安全位置，若否，则转步骤S141，若是，则转步骤S142。
S141：控制加试剂机构带动试剂针先上升到垂直初始位置，然后再水平旋转到安全位置。此过程中的垂直初始位置即试剂针抬离试剂盘一定高度且不影响试剂针水平旋转的位置。
S142：控制试剂针继续停止在安全位置，直到开始重新测试。
如图5所示为一种具体实施方式中试剂针移动到安全位置的示意图，平面示意图标示的有试剂盘101、与试剂盘101所对应的试剂针102、试剂针102的运动轨迹103、试剂针102的水平初始位置104、试剂盘201、与试剂盘201所对应的试剂针202、试剂针202的运动轨迹203、试剂针202的水平初始位置204、试剂针202的极限位置205和反应盘301。水平初始位置是指仪器停止时试剂针所处的位置。
当检测到试剂盘101上的试剂盘盖1（在图中未标示出）被打开时，此时试剂针102位于试剂盘101与水平初始位104（试剂针102完成正常加试剂动作后停留的位置）间，则控制加试剂机构带动试剂针102先上升到垂直初始位置，然后再水平旋转到水平初始位置104，否则按照正常流程完成动作后回到水平初始位104。若检测到试剂盘201上的试剂盘盖2（在图中未标示出）被打开，此时试剂针202位于试剂盘201与水平初始位204（试剂针202完成正常加试剂动作后停留的位置）间，同理也可运行到水平初始位置204或其附近，或者可运行到极限位置205（机械结构决定试剂针202可顺时针转动的最远位置）。否则按照正常流程完成动作后回到初始位置204。此步骤中的水平初始位置104为试剂针102的安全位置，水平初始位置204或极限位置205为试剂针202的安全位置。
在试剂针进行移动过程中，加试剂机构可能会碰撞其它物体，在又一具体实例中，加试剂机构上安装防撞传感器，当加试剂机构在运动过程中碰撞其它物体时，防撞传感器产生碰撞信号，在控制试剂针移动到安全位置的过程中还可以包括防撞保护，请参考图4，具体包括以下步骤：
S15：检测加试剂机构在运动过程中是否产生第一次碰撞信号，若是，则转步骤S16，若否，则转步骤S140，检测与试剂盘对应的试剂针是否位于安全位置。本实施例中，加试剂机构上安装有碰撞感应器，当加试剂机构在移动过程中某部位和其它物体发生碰撞时，碰撞感应器产生碰撞信号，处理和控制单元接收该碰撞信号，仪器管理模块根据第一次的碰撞信号进行处理。
S16：控制加试剂机构带动试剂针降低运动速度。防撞过程的移动速度较慢，小于步骤S141中的移动速度，以防止过快的移动损坏试剂针或加试剂机构的其它部位。
S17：检测试剂针在步骤S16运动过程中是否产生第二次碰撞信号，若是，则转步骤S18，若否，则转步骤S140，检测与试剂盘对应的试剂针是否位于安全位置。
S18：控制加试剂机构带动试剂针停留在当前位置不再运动，仪器完成不受试剂盘盖打开的影响的测试后，进入停机状态，从而使仪器得到保护。
在其它实施例中，防撞保护也可以是在检测到第一次碰撞信号时，即控制加试剂机构带动试剂针停留在当前位置不再运动。
本实施例采用的是对试剂盘和试剂针的保护，在其它实施例中，也可采用其它他保护方式，例如，仅进行试剂盘停转保护，或者对系统所有运动部件进行保护，即使得所有运动部件均回到初始位置。
实施例二：
本实施例在直接打开试剂盘盖进行试剂装载过程中，处理和控制单元不仅根据表示试剂盘开启的第一触发信号会发出仪器保护命令，还会根据第一触发信号对需要进行的测试进行测试管理。测试管理模块接收到的试剂盘开启信息可以直接是第一触发信号，也可以是经仪器管理模块转发或处理后的第一触发信号。请参考图6，测试管理具体步骤如下：
S21：产生表示试剂盘盖打开的第一触发信号。
S22：处理和控制单元接收第一触发信号，测试管理模块根据第一触发信号对需要进行的测试进行测试管理。
S23：判断测试项目的类型。测试管理模块根据当前测试进行的情况，判断试剂盘盖开启过程中执行保护命令对于已开始测试的影响，将已开始测试的项目分为两类，即可继续进行的测试项目和需要作废的测试项目。其中可继续进行的测试项目为完成相应试剂盘的加试剂的测试、不受试剂盘盖打开的影响的测试项目；需要作废的测试项目为未完成相应试剂盘的加试剂的测试且被打断的测试。如果是继续进行的测试项目，则转步骤S24，如果是需要作废的测试项目，转步骤S25。
S24：测试模块对可继续进行的测试项目继续进行测试，测试结束后给出测试结果。
S25：测试管理模块将需要作废的测试项目执行作废操作，不再继续执行。
S26：测试管理模块将作废的测试项目生成需要重新测试的重测项目，待再次开始测试时进行重测。
本实施例在接收到第一触发信号后对已开始的测试项目进行了分类管理，使不受试剂盘盖打开的影响的测试项目可继续进行测试，将受影响的测试项目作废，不再继续测试，以免导致错误结果。从而使得试剂盘盖被直接打开后测试能够有序无误的进行。
实施例三：
试剂装载完毕后，试剂盘盖被关闭，用户可通过手动启动仪器重新开始测试。本实施例在实施例一或二的基础上，在试剂盘盖被关闭后，使仪器自动启动而重新开始测试。
请参考图7，使仪器自动启动的方法包括如下步骤：
S31：产生表示试剂盘盖关闭的第二触发信号。当试剂装载完毕，试剂盘盖关闭时或即将关闭时，试剂盘盖监测装置410产生表示试剂盘盖关闭的第二触发信号。以试剂盘盖监测装置410为设置在试剂盘或试剂盘盖上用于感知试剂盘盖开合的传感器为例，当试剂盘盖关闭时，传感器信息发生变化，输出第二触发信号。
S32：处理和控制单元接收第二触发信号，仪器管理模块根据对与第二触发信号对应的试剂盘进行确认操作，确认操作可以包括确认当前试剂盘的对应试剂信息是否已更新，还可以包括确认与第二触发信号对应的试剂盘盖是否已经关闭，如果没有更新则根据采集的试剂信息进行更新，例如提示操作人员输入试剂原始信息，或控制扫描仪扫描新近被装载的试剂容器。
S33：仪器管理模块检测当前所有试剂盘盖是否均已经于关闭状态，若是，则转步骤S341，若否，则转步骤S342；
S341：仪器管理模块启动仪器恢复流程。仪器管理模块检查到所有试剂盘盘盖已经关闭时，则启动仪器恢复流程，将试剂盘和试剂加样单元恢复到初始位置，准备开始按照正常测试流程启动新的测试。恢复完成后，执行步骤S35；
S342：继续等待与未关闭的试剂盘盖对应的第二触发信号，转步骤S33；此步骤中，当处理和控制单元接收到与未关闭的试剂盘盖对应的第二触发信号后，又返回步骤S33，再次检测当前所有试剂盘盖是否都处于已关闭状态，如果还有试剂盘未关闭，则执行步骤S342，继续等待，直到确认所有的试剂盘盖都已关闭后再转步骤S341。
S35：仪器管理模块产生开始新测试的通知，并将通知发送给测试管理模块。
S36：测试管理模块根据开始新测试的通知自动重启测试，管理需要开始的新测试和因打开试剂盘作废需要进行重测的测试，并对需要进行的测试按照测试顺序进行排序，将需要进行测试的新测试项目和重测项目按照测试顺序生成测试信息。
S37：测试模块根据测试管理模块给定的测试信息，按照测试流程进行测试，并最终给出所有测试的测试结果。
根据本申请公开的内容，本领域技术人员应当理解，在另一具体实例中，仪器管理模块在接收到第二触发信号后也可以不检测当前所有试剂盘盖是否都处于已关闭状态，例如其流程可以是：先产生一个表示试剂盘盖关闭的第二触发信号，处理和控制单元接收第二触发信号，仪器管理模块根据第二触发信号启动仪器恢复流程，恢复完成后，即产生开始新测试的通知，并将通知发送给测试管理模块，由测试管理模块根据开始新测试的通知自动重启测试。
以上各实施例可适用单个试剂盘或者多个试剂盘，不受试剂盘数约束。
在另外的实施例中，测试过程中单个试剂盘盖打开后，可控制所有试剂盘及相应加试剂机构都回到初始位置或者极限位置，保证人员及仪器安全，所有试剂盘都支持试剂在线装载。
测试过程中试剂盘盖打开时，仪器进入可进行试剂装载的状态，但停止所有在进行的测试。
测试过程中打开试剂盘盖后又关闭试剂盘盖，仪器执行恢复时可选择多种恢复方式，例如仅恢复试剂针、试剂盘单元，或者恢复试剂针、试剂盘、样本针单元等。
测试过程中打开试剂盘盖后又关闭试剂盘盖，仪器自动启动测试后，打开盘盖过程中被作废的测试，不再执行自动重测，仅开始新的测试。
以上内容是结合具体的实施方式对本发明所作的进一步详细说明，不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干简单推演或替换。

Claims (14)

  1. 一种试剂装载方法，其特征在于包括：
    产生表示试剂盘盖打开的第一触发信号；
    处理和控制单元接收所述第一触发信号，根据所述第一触发信号发出仪器保护命令，所述仪器保护命令用于控制与第一触发信号对应的试剂盘停止转动，和控制加试剂机构带动与所述试剂盘对应的试剂针停止到安全位置，使仪器进入可装载试剂的状态。
  2. 如权利要求1所述的方法，其特征在于，控制加试剂机构带动与所述试剂盘对应的试剂针停止到安全位置包括：
    检测所述试剂针是否位于安全位置；
    如果是，则控制所述试剂针继续停止在安全位置；
    如果不是，则控制加试剂机构带动所述试剂针先上升到垂直初始位置，然后再水平旋转到安全位置。
  3. 如权利要求1或2所述的方法，其特征在于，处理和控制单元还根据所述第一触发信号对需要进行的测试进行测试管理，所述测试管理包括：判断可继续进行的测试项目和需要作废的测试项目，根据判断结果生成测试信息，根据测试信息进行测试，所述可继续进行的测试项目为已完成所述试剂盘的加试剂的测试项目，所述需要作废的测试项目为未完成所述试剂盘的加试剂的测试项目。
  4. 如权利要求3所述的方法，其特征在于，将作废的测试项目生成需要重新测试的重测项目。
  5. 如权利要求1至4中任一项所述的方法，其特征在于，在控制加试剂机构带动试剂针停止到安全位置的过程中还包括：
    检测试剂针在运动过程中是否产生第一次碰撞信号，如果是，则控制加试剂机构降低试剂针的运动速度；
    检测试剂针是否产生第二次碰撞信号，如果是，则控制加试剂机构带动所述试剂针停留在当前位置不再运动。
  6. 如权利要求1至4中任一项所述的方法，其特征在于，在控制加试剂机构带动试剂针停止到安全位置的过程中还包括：
    检测试剂针在运动过程中是否产生第一次碰撞信号，如果是，则控制加试剂机构带动所述试剂针停留在当前位置不再运动。
  7. 如权利要求1至4中任一项所述的方法，其特征在于，在产生试剂盘盖打开的第一触发信号后还包括：
    产生表示试剂盘盖关闭的第二触发信号；
    处理和控制单元接收所述第二触发信号，根据所述第二触发信号对与第二触发信号对应的试剂盘进行试剂更新操作，然后启动仪器恢复流程，所述仪器恢复流程包括：将试剂盘和加试剂机构恢复到初始位置，准备开始按照正常测试流程启动新的测试；
    仪器恢复流程完成后产生开始新测试的通知；
    根据开始新测试的通知自动重启测试，将需要进行测试的新测试项目和重测项目按照测试顺序生成测试信息，根据测试信息继续测试。
  8. 如权利要求7所述的方法，其特征在于，在对与第二触发信号对应的试剂盘进行确认操作之后和启动仪器恢复流程之前还包括：检测当前所有试剂盘盖是否均已经处于关闭状态，如果是则启动仪器恢复流程，否则继续等待与未关闭的试剂盘盖对应的第二触发信号。
  9. 一种试剂装载系统，其特征在于包括：
    试剂装载机构，其包括用于承载试剂容器、在驱动装置的带动下可转动的试剂盘，和覆盖在试剂盘上的试剂盘盖；
    试剂盘盖监测装置，其用于产生表示试剂盘盖打开的第一触发信号；
    加试剂机构，用于从试剂盘吸取试剂并加注到反应杯中；
    处理和控制单元，其用于接收第一触发信号，所述处理和控制单元包括仪器管理模块和试剂管理模块，所述仪器管理模块用于根据第一触发信号发出仪器保护命令，所述仪器保护命令用于控制与第一触发信号对应的试剂盘停止转动，和控制加试剂机构带动与所述试剂盘对应的试剂针停止到安全位置，试剂管理模块用于根据第一触发信号进入可装载试剂的状态。
  10. 如权利要求9所述的系统，其特征在于，所述处理和控制单元还包括用于管理测试项目的测试管理模块和测试模块，所述测试管理模块根据第一触发信号判断可继续进行的测试项目和需要作废的测试项目，根据判断结果生成测试信息；所述测试模块用于根据测试管理模块生成的测试信息进行测试，所述可继续进行的测试项目为已完成所述试剂盘的加试剂的测试项目，所述需要作废的测试项目为未完成所述试剂盘的加试剂的测试项目。
  11. 如权利要求9或10所述的系统，其特征在于，仪器管理模块在控制加试剂机构带动与所述试剂盘对应的试剂针停止到安全位置的过程中还检测加试剂机构在移动过程中是否产生第一次碰撞信号，如果是，则控制加试剂机构带动所述试剂针降低移动速度或停留在当前位置不再运动。
  12. 如权利要求9或10所述的系统，其特征在于，试剂盘盖监测装置还用于产生表示试剂盘盖关闭的第二触发信号，所述仪器管理模块还用于根据第二触发信号确认对与第二触发信号对应的试剂盘进行确认操作，然后启动仪器恢复流程，并在仪器恢复流程完成后产生开始新测试的通知；所述仪器恢复流程包括：将试剂盘和加试剂机构恢复到初始位置，准备开始按照正常测试流程启动新的测试；所述测试管理模块根据开始新测试的通知自动重启测试，将需要进行测试的新测试项目和作废后需要重新测试的重测项目按照测试顺序生成测试信息。
  13. 如权利要求12所述的系统，其特征在于，试剂盘盖监测装置包括设置在试剂盘或试剂盘盖上用于感知试剂盘盖开合的传感器、与处理和控制单元连接的按钮或允许用户操作的人机交互界面。
  14. 一种生化分析仪，其特征在于包括如权利要求9至13中任一项所述的试剂装载系统。
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