WO2014061158A1 - Ensemble cuve à circulation - Google Patents

Ensemble cuve à circulation Download PDF

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Publication number
WO2014061158A1
WO2014061158A1 PCT/JP2012/077139 JP2012077139W WO2014061158A1 WO 2014061158 A1 WO2014061158 A1 WO 2014061158A1 JP 2012077139 W JP2012077139 W JP 2012077139W WO 2014061158 A1 WO2014061158 A1 WO 2014061158A1
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WO
WIPO (PCT)
Prior art keywords
flow cell
heater
diffusion sheet
adhesive
heat
Prior art date
Application number
PCT/JP2012/077139
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English (en)
Japanese (ja)
Inventor
諭史 松岡
叶井　正樹
正憲 西野
Original Assignee
株式会社島津製作所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社島津製作所 filed Critical 株式会社島津製作所
Priority to PCT/JP2012/077139 priority Critical patent/WO2014061158A1/fr
Publication of WO2014061158A1 publication Critical patent/WO2014061158A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/30—Control of physical parameters of the fluid carrier of temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/30—Control of physical parameters of the fluid carrier of temperature
    • G01N2030/3007—Control of physical parameters of the fluid carrier of temperature same temperature for whole column
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/30—Control of physical parameters of the fluid carrier of temperature
    • G01N2030/3053—Control of physical parameters of the fluid carrier of temperature using resistive heating
    • G01N2030/3061—Control of physical parameters of the fluid carrier of temperature using resistive heating column or associated structural member used as heater
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6086—Construction of the column body form designed to optimise dispersion

Definitions

  • the present invention relates to, for example, an analysis column of a gas chromatograph apparatus, a flow cell used as a reaction cell of an analysis apparatus or a reaction apparatus, and a flow cell unit including a heating unit for heating the flow cell.
  • a flat plate flow cell having a flow path inside is used in various fields, it is often required that the temperature of the flow path in the flow cell be maintained uniformly. For example, in a microreactor, it is desirable that the temperature of the flow path is constant in order to keep the reaction conditions constant.
  • MEMS Micro Electro Mechanical Systems
  • the heating of the flat plate type flow cell is performed by bringing a flat plate type heater or a heater block into contact with one plane of the flow cell.
  • a flat heater or heater block has a temperature distribution in its own plane, if it is heated by direct contact with the flow cell, the temperature distribution is generated in the flow cell and cannot be heated uniformly.
  • the flow cell is made of a material with high thermal conductivity such as aluminum or silicon, the temperature of the flow cell is maintained to a certain level by the heat conduction of the material itself, but the flow cell is a material with low thermal conductivity such as stainless steel or glass. It is difficult to keep the temperature of the flow cell uniform. Even if the material of the flow cell has a high thermal conductivity, the in-plane temperature uniformity may be insufficient depending on the required specifications.
  • a heat diffusion sheet having high thermal conductivity is sandwiched between the heater or heater block and the flow cell, and heat from the heater or heater block is uniformly transmitted to the flow cell via the heat diffusion sheet. It is common to do so.
  • a sheet having anisotropic thermal conductivity for example, a graphite sheet is suitable.
  • a heat diffusion sheet having an anisotropic thermal conductivity, such as a graphite sheet conducts more heat in the surface direction than in the thickness direction, and therefore the temperature is not uniform in the heating section such as a flat plate heater or heater block. However, heat can be uniformly transferred to the flow cell.
  • the adhesive on the surface of a commercially available heat diffusion sheet generally has an upper limit temperature of about 100 to 200 ° C. and cannot be used in applications where the temperature reaches 400 ° C. by heating. Therefore, a heater block with high rigidity is used as the heating part that heats the flow cell, a heat diffusion sheet without adhesive is sandwiched between the flow cell and the heater block, and the flow cell and the heater block are tightened with screws. Can be considered.
  • the contact between the heater and the thermal diffusion sheet or between the thermal diffusion sheet and the flow cell is partially insufficient, the contact thermal resistance at the interface increases at the insufficient contact portion, and the responsiveness in temperature control decreases. In addition, there is a problem that the cooling rate is lowered.
  • the reproducibility of the contact state between the heater and the heat diffusion sheet or between the heat diffusion sheet and the flow cell is not ensured, and the reproducibility of the flow cell temperature becomes low. The reproducibility of data obtained by analysis may be low.
  • an object of the present invention is to provide a flow cell unit capable of controlling the temperature of the flow cell uniformly and with good responsiveness.
  • a flow cell unit includes a flow cell including a flow path substrate in which a flow path for flowing a sample is formed, a flat plate heater for heating the flow cell, and a flat surface of the flow cell and a heating surface of the heater.
  • a thermal diffusion sheet having an anisotropic thermal conductivity that is sandwiched and has a thermal conductivity in the in-plane direction larger than that in the thickness direction, and is interposed between one plane of the flow cell and the thermal diffusion sheet.
  • an adhesive layer made of a heat-resistant adhesive that adheres the thermal diffusion sheet to one plane of the flow cell.
  • the “thermal diffusion sheet having anisotropic thermal conductivity” refers to a film-like member whose thermal conductivity in the plane direction is several times or more, for example, twice or more higher than the thermal conductivity in the thickness direction. .
  • the “heat-resistant adhesive” refers to an adhesive having high heat resistance of 400 ° C. or higher. Examples of such an adhesive include an inorganic binder that vitrifies by heating, a filler made of ceramic or graphite, and an inorganic ceramic adhesive or graphite adhesive mainly composed of water (solvent).
  • the heat having an anisotropic thermal conductivity is greater between the one plane of the flow cell and the heating surface of the heater than the thermal conductivity in the thickness direction in the in-plane direction. Since the diffusion sheet is sandwiched, the heat of the heater can be uniformly transmitted to one plane of the flow cell. Since the heat diffusion sheet is adhered to one plane of the flow cell with a heat-resistant adhesive, the heat diffusion sheet can be uniformly in contact with one plane of the flow cell, and the flow cell can be heated uniformly in the plane. . Since the thermal diffusion sheet is bonded to one plane of the flow cell with an adhesive, the thermal resistance of the interface between the flow cell and the thermal diffusion sheet is reduced, and the heat transfer efficiency between the flow cell and the thermal diffusion sheet is improved.
  • the response in the temperature control of the flow cell and the cooling rate can be improved. Since the positional relationship between the flow cell and the thermal diffusion sheet is fixed by the adhesive, the contact state between the flow cell and the thermal diffusion sheet does not change when the user exchanges the flow cell, and the reproducibility of the measurement data is improved. Further, when the heat diffusion sheet is adhered to a plane opposite to the one plane on the heater side of the flow cell with a heat-resistant adhesive, the heat distribution in the plane of the flow cell becomes more uniform.
  • the thermal diffusion sheet is a laminate of a plurality of thermal diffusion sheets, and each thermal diffusion sheet has a greater thermal conductivity in the in-plane direction than in the thickness direction. It is preferable that it has anisotropic thermal conductivity and that the heat diffusion sheets are also bonded with a heat-resistant adhesive. If it does so, the heat from a heater can be made more uniform in a surface, and can be transmitted to a flow cell.
  • the heating surface of the heater and the heat diffusion sheet may be bonded with a heat-resistant adhesive. Then, the contact between the heating surface of the heater and the thermal diffusion sheet is improved, so that the thermal resistance between the heating surface of the heater and the thermal diffusion sheet is reduced, and the heat transfer efficiency is improved. The responsiveness in temperature control is improved, the contact condition between the heating surface of the heater and the heat diffusion sheet is not changed, and the data reproducibility is improved. In addition, the cooling rate of the flow cell is improved.
  • a heat diffusion sheet having an anisotropic thermal conductivity in which the thermal conductivity in the in-plane direction is larger than the thermal conductivity in the thickness direction is also heat resistant on the plane opposite to the one plane on the heater side of the flow cell It may be adhered by an adhesive. By doing so, the temperature distribution in the surface of the flow cell can be made more uniform.
  • Examples of the adhesive used in the flow cell unit of the present invention include a ceramic adhesive having a heat resistance of 400 ° C. or higher, a graphite adhesive, or a zirconia adhesive.
  • a graphite sheet is an example of the heat diffusion sheet.
  • the present invention can obtain a greater effect particularly when applied to a flow cell unit in which the flow cell is made of stainless steel or glass.
  • the case where a flow cell made of stainless steel or glass having a low thermal conductivity is used is a case where a flow cell made of aluminum or silicon having a high thermal conductivity cannot be used due to a decrease in strength at high temperatures or brittleness. .
  • This flow cell unit includes a flat plate type flow cell 2 formed by stacking a plurality of substrates.
  • the flow cell 2 is provided with a flow path 4 therein.
  • An end 6 of the flow path 4 leads to the upper plane of the flow cell 2, and a capillary 9 is connected thereto via a connector 8.
  • a capillary is connected to the other end of the flow path via a connector having a similar structure.
  • the material of the flow cell 2 is preferably a material having high thermal conductivity such as aluminum or silicon, but may be glass or stainless steel when those materials cannot be used depending on the use conditions.
  • the flow path 4 is a single flow path formed in a meandering shape in one plane in the flow cell 2.
  • a flat plate type mica heater (heater) 14 is mounted on the lower surface of the flow cell 2. Between the lower surface of the flow cell 2 and the heater 14, an adhesive layer 10 and a thermal diffusion sheet 12 having anisotropic thermal conductivity are interposed.
  • the thermal diffusion sheet 12 is a film-like member whose thermal conductivity in the plane direction is several times to several tens of times higher than the thermal conductivity in the thickness direction, and the material thereof is, for example, graphite.
  • the adhesive layer 10 is a layer made of, for example, a ceramic adhesive, a graphite adhesive, or a zirconia adhesive, and has a heat resistance of 1300 ° C. or higher.
  • the thickness of the adhesive layer 10 is 0.1 mm or less.
  • the adhesive layer 10 is adhered between the lower surface of the flow cell 2 and the heat diffusion sheet 12 and is pressed from both sides of the flow cell 2 side and the heat diffusion sheet 12 side so that the flow cell 2 and the heat diffusion sheet 12 are bonded. It has been uniformly stretched and cured so as to cover the entire bonding surface of each other.
  • the lower surface of the flow cell 2 and the thermal diffusion sheet 12 are bonded with an adhesive.
  • a metal plate 16 made of stainless steel or the like is in contact with the surface opposite to the flow cell 2 which is one surface of the heater 14.
  • the presence of a heating target on only one surface of a flat-plate heater can cause a significant temperature difference between the two surfaces of the heater, causing warpage due to a difference in thermal expansion, or in the worst case leading to destruction of the heater. This is because it is not preferable.
  • the flow cell 2, the thermal diffusion sheet 12, the heater 14, and the plate material 16 have, for example, a main plane of 100 mm square, and holes through which the screws 20 pass are provided at the corners.
  • the flow cell 2 has a thickness of, for example, 1 mm
  • the thermal diffusion sheet 12 has a thickness of, for example, 0.3 mm
  • the heater 14 has a thickness of, for example, 1 mm
  • the plate member 16 has a thickness of, for example, 1 mm.
  • the flow cell 2, the thermal diffusion sheet 12, the heater 14, and the plate material 16 are fixed in a stacked state by fastening screws 20.
  • the output of the heater 14 is controlled by the temperature controller 18.
  • the temperature controller 18 controls the output of the heater 14 based on a signal from a temperature sensor (not shown) attached to the flow cell 2 so that the flow cell 2 reaches a predetermined temperature.
  • the adhesive layer 10 has high heat resistance, the adhesion between the flow cell 2 and the thermal diffusion sheet 12 can be maintained even when the temperature reaches 400 ° C. or higher. Thereby, even if the temperature of the heating surface of the heater 14 is non-uniform, the heat from the heater 14 is made uniform in the surface by the anisotropic thermal conductivity of the heat diffusion sheet 12 and then reliably supplied to the flow cell 2. Therefore, the flow cell 2 can be heated uniformly in the plane.
  • the flow cell 2 When the flow cell 2 is made of a material having high thermal conductivity such as aluminum or silicon, even if heat is transferred from the heater 14 to the flow cell 2 in a non-uniform manner in the surface, the flow cell 2 itself equalizes the heat to some extent. Therefore, the temperature distribution generated in the flow cell 2 is made uniform over time, but the thermal diffusion sheet 12 is sandwiched between the flow cell 2 and the heater 14, and the thermal diffusion sheet 12 is bonded with an adhesive. By adhering to the flow cell 2, the heat from the heater 14 can be made uniform in the surface and reliably transmitted to the flow cell 2, the temperature of the flow cell 2 is made more uniform, and the time until it is made uniform is also shortened.
  • the thermal conductivity such as aluminum or silicon
  • the flow cell 2 is made of a material having a relatively low thermal conductivity such as glass or stainless steel, if the heat from the heater 14 is transmitted to the flow cell 2 in a non-uniform manner in the surface, the temperature of the flow cell 2 is not stable. It becomes uniform and cannot be improved. Therefore, the heat diffusion sheet 12 is sandwiched between the flow cell 2 and the heater 14 and adhered to the flow cell 2 with an adhesive, so that the heat from the heater 14 is uniformly transmitted to the flow cell 2 and the flow cell 2 is uniform. To be heated.
  • an adhesive layer 10a made of a ceramic adhesive, a graphite adhesive, or a zirconia adhesive is interposed between the flow cell 2 and the thermal diffusion sheet 12, and the thermal diffusion sheet 12 and the heater.
  • a similar adhesive layer 10b may be interposed between the first and second adhesive layers.
  • the adhesion between the heat diffusion sheet 12 and the heater 14 can be improved by bonding the heat diffusion sheet 12 and the heater 14 with an adhesive, and heat transfer from the heater 14 to the heat diffusion sheet 12 is achieved. Efficiency can be improved. Thereby, the responsiveness in the temperature control of the flow cell 2 can be improved. Moreover, the cooling rate of the whole system can also be improved by improving the heat transfer efficiency between the heater 14 and the thermal diffusion sheet 12.
  • the flow cell 2 unit may be sandwiched between the flow cell 2 and the heater 14 in a state where the heat diffusion sheets are stacked so that the heat capacity of the unit does not become too large. If it does so, the effect which equalizes the heat transmitted from the heater 14 to the flow cell 2 can be improved.
  • FIG. 3 shows an embodiment in which two heat diffusion sheets 12a and 12b are stacked and sandwiched between the flow cell 2 and the heater.
  • An adhesive layer 10a is interposed between the thermal diffusion sheet 12a and the lower surface of the flow cell 2
  • an adhesive layer 10b is interposed between the thermal diffusion sheets 12a and 12b, and the thermal diffusion sheet 12b and the heater 14 are interposed. Is interposed by an adhesive layer 10c.
  • FIG. 5A and 5B are cross-sectional views of the apparatus used in the experiment for verifying the effect (1).
  • a graphite sheet (thermal diffusion sheet) 30 is disposed on the upper surface of the flat heater 26.
  • a stainless steel plate 34 is disposed on the graphite sheet 30 via an adhesive layer 32, and the graphite sheet 30 and the stainless steel plate 34 are bonded by an adhesive.
  • a stainless steel plate 28 is also disposed on the lower surface side of the heater 26. These members are fixed in a stacked state by fastening screws 36.
  • the apparatus of FIG. 5B is different from the apparatus of FIG. 5A in that the adhesive layer 32 is not interposed between the graphite sheet 30 and the stainless steel plate 34.
  • FIG. 6A and FIG. 6B show the temperature of the upper surface of the stainless steel plate 34 measured by a thermograph when the heater 26 is heated at 100 W and the temperature of the heater 26 reaches 50 ° C.
  • FIG. 6A shows that the temperature distribution is a central object compared to FIG. 6B. 5B, the contact between the graphite sheet 30 and the stainless steel plate 34 was non-uniform in the apparatus of FIG. 5B, whereas the graphite sheet 30 and the stainless steel plate 34 were bonded with an adhesive in the apparatus of FIG. 5A. This shows that the contact between them is uniform.
  • 7A and 7B are cross-sectional views of the apparatus used in the experiment for verifying the effect (2).
  • 7A has a stainless steel plate 40a, a graphite sheet (thermal diffusion sheet) 42a, an adhesive layer 44a, a stainless steel plate 40b, an adhesive layer 44b, a graphite sheet 42b, and a stainless steel plate 40c stacked from below. 46 is fixed.
  • the device of FIG. 7B differs from the device of FIG. 7A in that the adhesive layers 44a and 44b are not provided.
  • thermocouples 48a and 48b were embedded in stainless plates 40b and 40c, respectively, and these devices were housed in an oven equipped with a heater, and the oven temperature was increased from 30 ° C. to 70 ° C. at 10 ° C./min.
  • the temperature difference between the two stainless steel plates 40b and 40c was measured.
  • the thermal resistance at the interface between the stainless steel plate 40b and the graphite sheet 42b is affected by the presence or absence of the adhesive layer 44b. If the thermal resistance at the interface between the stainless steel plate 40b and the graphite sheet 42b is large, the temperature difference between the stainless steel plates 40b and 40c becomes large. If the thermal resistance at the interface between the stainless steel plate 40b and the graphite sheet 42b is small, the stainless steel plate 40b The temperature difference of 40c becomes small.
  • Measurement data using the apparatus of FIG. 7A is FIG. 8A
  • measurement data using the apparatus of FIG. 7B is FIG. 8B.
  • the temperature difference between the stainless plates 40b and 40c was about 0.4 to 0.5 ° C.
  • the stainless plates 40b and 40c The temperature difference is about 0.1 ° C. This shows that the thermal resistance of the interface between the stainless steel plate 40b and the graphite sheet 42b is reduced by bonding the stainless steel plate 40b and the graphite sheet 42b with an adhesive.
  • a flat heater 14a is mounted on the lower surface side of the flow cell 2a. Between the flow cell 2a and the heater 14a, an adhesive layer 10d, a thermal diffusion sheet 12d, an adhesive layer 10e, a thermal diffusion sheet 12e, and an adhesive layer 10f are interposed from the flow cell 2a side.
  • the thermal diffusion sheets 12d and 12e are flat plate members made of graphite, for example, and the thickness is about 0.3 mm, for example.
  • the adhesive layers 10d, 10e, and 10f are formed by hardening a ceramic adhesive, a graphite adhesive, or a zirconia adhesive into a film having a thickness of 0.1 mm or less.
  • the flow cell 2a and the thermal diffusion sheet 12d, the thermal diffusion sheets 12d and 12e, and the thermal diffusion sheet 12e and the heater 14a are bonded to each other with the above-described adhesive.
  • two heat diffusion sheets 12d and 12e are sandwiched between the flow cell 2a and the heater 14a in order to more uniformly transfer the heat from the heater 14a to the flow cell 2a.
  • the number of heat diffusion sheets between the flow cell 2a and the heater 14a may be one, or three or more.
  • a metal plate 16a made of stainless steel, for example, is in contact with the surface of the heater 14a opposite to the flow cell 2a.
  • the presence of an object to be heated only on one surface of the flat heater 14a may cause a significant temperature difference between the two surfaces of the heater, causing warpage due to a difference in thermal expansion, or in the worst case leading to destruction of the heater. This is because it is not preferable.
  • a plate 22 made of an adhesive layer 10g, a heat diffusion sheet 12e, stainless steel, and the like is mounted on the surface of the flow cell 2a opposite to the heater 14a from the flow cell 2a side. The thermal diffusion sheet 12e is bonded to the upper surface of the flow cell 2a with an adhesive.
  • the heat diffusion sheet 12e is adhered to the surface of the flow cell 2a opposite to the heater 14a with an adhesive, the temperature of the flow cell 2a can be further uniformized.
  • the heat diffusion sheet 12e and the adhesive layer 10g on the upper surface side of the flow cell 2a are not essential, and the heat diffusion sheet 12e and the adhesive layer 10g may not be provided, or the heat diffusion sheet 12e is directly flow cell. It may be in contact with the upper surface of 2a.
  • the plate material 22, the heat diffusion sheet 12e, the flow cell 2a, the heat diffusion sheets 12c and 12d, the heater 14a, and the plate material 16a constituting the flow cell unit have, for example, a main surface of 100 mm square, and a screw 20a is penetrated at the corner. Each hole is provided.
  • the plate material 22, the heat diffusion sheet 12e, the flow cell 2a, the heat diffusion sheets 12c and 12d, the heater 14a, and the plate material 16a are fixed in a stacked state by fastening screws 20a.
  • the metal plate 22 on the upper surface side of the flow cell 2a does not necessarily exist, but when the flow cell 2a is a thin chip, the flow cell 2a is fastened by fastening the screw 20a due to the presence of the metallic member 22. The distortion can be prevented. In addition, when there is a flow or temperature change in the surrounding air, the temperature of the flow cell 2a can be stably maintained by the presence of the metal member 22.
  • the output of the heater 14a is controlled by the temperature controller 18a.
  • the temperature controller 18a controls the output of the heater 14a based on a signal from a temperature sensor (not shown) attached to the flow cell 2a so that the flow cell 2a reaches a predetermined temperature.

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Abstract

Un ensemble cuve à circulation comprend une cuve à circulation constituée d'un substrat dont la surface est sillonnée de canaux dans lesquels s'écoule un échantillon, ainsi qu'un dispositif de chauffage à plaques destiné à chauffer ladite cuve à circulation. Une plaque diffusant la chaleur, présentant une conductivité thermique anisotrope telle à ce que sa conductivité thermique dans le sens de la surface est supérieure à sa conductivité thermique dans le sens de l'épaisseur, est introduite entre une face de la cuve à circulation et la face chauffante du dispositif de chauffage. Une couche adhésive, constituée d'un adhésif thermorésistant, est intercalée entre une face de la cuve à circulation et la plaque diffusant la chaleur.
PCT/JP2012/077139 2012-10-19 2012-10-19 Ensemble cuve à circulation WO2014061158A1 (fr)

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PCT/JP2012/077139 WO2014061158A1 (fr) 2012-10-19 2012-10-19 Ensemble cuve à circulation

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PCT/JP2012/077139 WO2014061158A1 (fr) 2012-10-19 2012-10-19 Ensemble cuve à circulation

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EP3190419A1 (fr) * 2016-01-08 2017-07-12 Honeywell International Inc. Pointe de sonde pour sonde de données d'air
US9719820B1 (en) 2016-01-29 2017-08-01 Goodrich Aerospace Services Private Limited Hybrid material pitot tube
JP2017527811A (ja) * 2014-09-13 2017-09-21 アジレント・テクノロジーズ・インクＡｇｉｌｅｎｔ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． ガスクロマトグラフィ（ｇｃ）カラムヒータ
CN108982754A (zh) * 2017-06-05 2018-12-11 深圳迈瑞生物医疗电子股份有限公司 试剂预热及反应装置和样本分析仪

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JPH09322755A (ja) * 1996-06-05 1997-12-16 Rikagaku Kenkyusho 微量検体のためのインキュベーター
JPH1157996A (ja) * 1997-08-21 1999-03-02 Matsushita Electric Ind Co Ltd こて先部材および半田ごて
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JP2017527811A (ja) * 2014-09-13 2017-09-21 アジレント・テクノロジーズ・インクＡｇｉｌｅｎｔ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． ガスクロマトグラフィ（ｇｃ）カラムヒータ
JP2020024209A (ja) * 2014-09-13 2020-02-13 アジレント・テクノロジーズ・インクＡｇｉｌｅｎｔ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． 装置
EP3190419A1 (fr) * 2016-01-08 2017-07-12 Honeywell International Inc. Pointe de sonde pour sonde de données d'air
CN107064536A (zh) * 2016-01-08 2017-08-18 霍尼韦尔国际公司 用于空气数据探针的探针尖端
US9891083B2 (en) 2016-01-08 2018-02-13 Honeywell International Inc. Probe tip for air data probe
US10605637B2 (en) 2016-01-08 2020-03-31 Honeywell International Inc. Probe tip for air data probe
US9719820B1 (en) 2016-01-29 2017-08-01 Goodrich Aerospace Services Private Limited Hybrid material pitot tube
EP3199955A1 (fr) * 2016-01-29 2017-08-02 Goodrich Aerospace Services Private Limited Tube pitot avec une pièce d'insertion conductrice de chaleur
CN107037234A (zh) * 2016-01-29 2017-08-11 古德里奇航天服务私人有限公司 杂化材料制皮托管
CN108982754A (zh) * 2017-06-05 2018-12-11 深圳迈瑞生物医疗电子股份有限公司 试剂预热及反应装置和样本分析仪
CN108982754B (zh) * 2017-06-05 2024-04-12 深圳迈瑞生物医疗电子股份有限公司 试剂预热及反应装置和样本分析仪

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