WO2014056723A1 - Formulation aqueuse stérile injectable à base d'acide hyaluronique réticulé et d'hydroxyapatite pour usage thérapeutique - Google Patents
Formulation aqueuse stérile injectable à base d'acide hyaluronique réticulé et d'hydroxyapatite pour usage thérapeutique Download PDFInfo
- Publication number
- WO2014056723A1 WO2014056723A1 PCT/EP2013/069877 EP2013069877W WO2014056723A1 WO 2014056723 A1 WO2014056723 A1 WO 2014056723A1 EP 2013069877 W EP2013069877 W EP 2013069877W WO 2014056723 A1 WO2014056723 A1 WO 2014056723A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aqueous formulation
- sterile injectable
- injectable aqueous
- gel
- hyaluronic acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/738—Cross-linked polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES13766119.5T ES2595252T3 (es) | 2012-10-08 | 2013-09-24 | Formulación acuosa estéril inyectable a base de ácido hialurónico reticulado y de hidroxiapatita para uso terapéutico |
JP2015534961A JP6476120B2 (ja) | 2012-10-08 | 2013-09-24 | 治療的使用のための架橋ヒアルロン酸及びハイドロキシアパタイトに基づく注入用無菌水性製剤 |
MX2015004165A MX2015004165A (es) | 2012-10-08 | 2013-09-24 | Formulacion acuosa esteril inyectable a base de acido hialuronico reticulado y de hidroxiapatita para uso terapeutico. |
CN201380052557.3A CN104853742B (zh) | 2012-10-08 | 2013-09-24 | 用于治疗用途的基于交联透明质酸和羟基磷灰石的可注射无菌水性制剂 |
RU2015109085A RU2015109085A (ru) | 2012-10-08 | 2013-09-24 | Стерильный инъецируемый водный состав на основе сшитой гиалуроновой кислоты и гидроксиапатита для терапевтического применения |
EP13766119.5A EP2903591B1 (fr) | 2012-10-08 | 2013-09-24 | Formulation aqueuse stérile injectable à base d'acide hyaluronique réticulé et d'hydroxyapatite pour usage thérapeutique |
US14/433,089 US20150238525A1 (en) | 2012-10-08 | 2013-09-24 | Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and on hydroxyapatite, for therapeutic use |
CA 2885884 CA2885884A1 (fr) | 2012-10-08 | 2013-09-24 | Formulation aqueuse sterile injectable a base d'acide hyaluronique reticule et d'hydroxyapatite pour usage therapeutique |
BR112015007746A BR112015007746A2 (pt) | 2012-10-08 | 2013-09-24 | formulação aquosa estéril injetável, kit contendo a formulação aquosa estéril injetável e processo de fabricação de uma formulação aquosa estéril injetável |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1259582 | 2012-10-08 | ||
FR1259582 | 2012-10-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2014056723A1 true WO2014056723A1 (fr) | 2014-04-17 |
Family
ID=47295067
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2013/069877 WO2014056723A1 (fr) | 2012-10-08 | 2013-09-24 | Formulation aqueuse stérile injectable à base d'acide hyaluronique réticulé et d'hydroxyapatite pour usage thérapeutique |
Country Status (12)
Country | Link |
---|---|
US (1) | US20150238525A1 (fr) |
EP (1) | EP2903591B1 (fr) |
JP (1) | JP6476120B2 (fr) |
CN (1) | CN104853742B (fr) |
AR (1) | AR092934A1 (fr) |
BR (1) | BR112015007746A2 (fr) |
CA (1) | CA2885884A1 (fr) |
ES (1) | ES2595252T3 (fr) |
MX (1) | MX2015004165A (fr) |
RU (2) | RU2015109085A (fr) |
TW (1) | TW201427697A (fr) |
WO (1) | WO2014056723A1 (fr) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016074794A1 (fr) * | 2014-11-13 | 2016-05-19 | Merz Pharma Gmbh & Co. Kgaa | Charge dermique à base d'acide hyaluronique réticulé et de lubrifiant de carboxyméthylcellulose |
EP3354258A1 (fr) | 2017-01-31 | 2018-08-01 | Teoxane SA | Utilisation d'un gel cohésif en tant que matériau de matrice dans une poche parodontale |
WO2019135729A1 (fr) * | 2018-01-03 | 2019-07-11 | Светлана Александровна ЛАРКИНА | Composition pour injections esthétiques |
WO2019197608A1 (fr) | 2018-04-13 | 2019-10-17 | Merz Pharma Gmbh & Co. Kgaa | Charge dermique à base d'acide hyaluronique réticulé, de particules de matière de phosphate de calcium et de carboxyméthylcellulose, son procédé de préparation et ses utilisations |
WO2020095079A1 (fr) * | 2018-11-06 | 2020-05-14 | Kylane Laboratoires Sa | Composition injectable contenant de l'acide hyaluronique pour des applications au niveau du corps |
US10688044B2 (en) | 2018-03-19 | 2020-06-23 | Bryn Pharma, LLC | Epinephrine spray formulations |
WO2021156345A1 (fr) * | 2020-02-06 | 2021-08-12 | Merz Pharma Gmbh & Co. Kgaa | Composition injectable pour l'augmentation de la peau et des tissus mous |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6342906B2 (ja) | 2012-10-08 | 2018-06-13 | アンティース ソシエテ アノニム | 架橋されたヒアルロン酸及びヒドロキシアパタイトに基づく、美容用途のための注射可能な無菌水性製剤 |
US10463762B2 (en) * | 2012-10-08 | 2019-11-05 | Anteis S.A. | Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use |
US10434040B2 (en) | 2012-10-08 | 2019-10-08 | Anteis S.A. | Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use |
FR3044557B1 (fr) * | 2015-12-07 | 2017-12-01 | Benedicte Vincente Gavard Molliard Tauzin | Nouvelle composition injectable; procede de preparation de ladite composition; utilisation de ladite composition |
EP3377126B1 (fr) | 2016-07-27 | 2019-05-22 | Marbelle Threads Ltd. | Fils d'acide hyaluronique réticulé et d'hydroxyapatite |
WO2018047182A1 (fr) | 2016-09-07 | 2018-03-15 | Luminera Derm Ltd. | Gels injectables comprenant de l'acide hyaluronique réticulé et de l'hydroxyapatite, et leurs procédés de fabrication |
WO2018220283A1 (fr) * | 2017-05-29 | 2018-12-06 | Kh Medtech Sarl | Composition injectable sterile contenant de l'acide hyaluronique reticule et de l'articaine |
CN107496990A (zh) * | 2017-08-15 | 2017-12-22 | 广东泰宝医疗器械技术研究院有限公司 | 一种可注射的抗菌软骨修复水凝胶及其制备方法 |
CN110636870A (zh) * | 2017-10-10 | 2019-12-31 | 依娜完美护肤解决方案有限公司 | 制备包含透明质酸和羟基磷灰石的真皮填充物组合物的方法以及包含透明质酸和羟基磷灰石的真皮填充物组合物 |
KR20200046649A (ko) | 2018-10-25 | 2020-05-07 | (주)뉴크레이티브랩 | 혼합상 히알루론산 제조방법 |
WO2021247348A1 (fr) * | 2020-06-01 | 2021-12-09 | Bone Solutions, Inc. | Composition de biomatériau et méthodes d'utilisation |
CN116173251B (zh) * | 2022-12-09 | 2023-12-01 | 上海蓝晶生物科技有限公司 | 一种pha微球注射剂的灭菌方法 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922025A (en) * | 1992-02-11 | 1999-07-13 | Bristol-Myers Squibb Company | Soft tissue augmentation material |
WO1999038543A2 (fr) * | 1998-01-28 | 1999-08-05 | Regeneration Technologies, Inc. | Colle a os traitee par irradiation et chauffage |
WO2005051446A1 (fr) * | 2003-11-27 | 2005-06-09 | Fidia Advanced Biopolymers S.R.L. | Structures composites contenant de l'acide hyaluronique et ses derives utilisables, nouveaux substituts osseux et materiaux de greffes osseuses |
US20060040894A1 (en) * | 2004-08-13 | 2006-02-23 | Angiotech International Ag | Compositions and methods using hyaluronic acid |
WO2007009477A1 (fr) * | 2005-07-21 | 2007-01-25 | Lisopharm Ag | Procede de production de particules d'hydroxyapatite, notamment de particules d'hydroxyapatite sous-nanodispersees dans une matrice |
FR2938187A1 (fr) * | 2008-11-07 | 2010-05-14 | Anteis Sa | Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur |
WO2010136694A2 (fr) * | 2009-05-26 | 2010-12-02 | Anteis S.A. | Hydrogel injectable permettant une supplementation en glycerol dans la peau sur le long terme |
WO2012080915A1 (fr) * | 2010-12-17 | 2012-06-21 | Anteis S.A. | Formulation aqueuse injectable stérile utilisée en ophtalmologie |
WO2013053457A1 (fr) * | 2011-10-12 | 2013-04-18 | Regenyal Laboratories S.R.L. | Synthèse d'un gel multiphasique injectable contenant de l'acide hyaluronique monophasique libre et réticulé et de l'acide hyaluronique biphasique en association avec de l'hydroxyapatite et un inhibiteur de l'hyaluronidase microencapsulé |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002058736A (ja) * | 2000-08-17 | 2002-02-26 | Seikagaku Kogyo Co Ltd | 骨充填用組成物、骨充填用医療用具及び骨充填用キット |
CN101039683A (zh) * | 2004-08-13 | 2007-09-19 | 血管技术国际有限公司 | 使用透明质酸和透明质酸酶抑制剂的组合物和方法 |
CN101596328A (zh) * | 2008-06-02 | 2009-12-09 | 山东省生物药物研究院 | 一种复合生物材料及其制备方法和应用 |
JP6342906B2 (ja) * | 2012-10-08 | 2018-06-13 | アンティース ソシエテ アノニム | 架橋されたヒアルロン酸及びヒドロキシアパタイトに基づく、美容用途のための注射可能な無菌水性製剤 |
-
2013
- 2013-09-24 CN CN201380052557.3A patent/CN104853742B/zh not_active Expired - Fee Related
- 2013-09-24 US US14/433,089 patent/US20150238525A1/en not_active Abandoned
- 2013-09-24 EP EP13766119.5A patent/EP2903591B1/fr not_active Not-in-force
- 2013-09-24 BR BR112015007746A patent/BR112015007746A2/pt not_active Application Discontinuation
- 2013-09-24 RU RU2015109085A patent/RU2015109085A/ru not_active Application Discontinuation
- 2013-09-24 ES ES13766119.5T patent/ES2595252T3/es active Active
- 2013-09-24 JP JP2015534961A patent/JP6476120B2/ja not_active Expired - Fee Related
- 2013-09-24 CA CA 2885884 patent/CA2885884A1/fr not_active Abandoned
- 2013-09-24 RU RU2018134453A patent/RU2018134453A/ru not_active Application Discontinuation
- 2013-09-24 WO PCT/EP2013/069877 patent/WO2014056723A1/fr active Application Filing
- 2013-09-24 MX MX2015004165A patent/MX2015004165A/es unknown
- 2013-10-08 AR ARP130103636A patent/AR092934A1/es unknown
- 2013-10-08 TW TW102136384A patent/TW201427697A/zh unknown
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922025A (en) * | 1992-02-11 | 1999-07-13 | Bristol-Myers Squibb Company | Soft tissue augmentation material |
WO1999038543A2 (fr) * | 1998-01-28 | 1999-08-05 | Regeneration Technologies, Inc. | Colle a os traitee par irradiation et chauffage |
WO2005051446A1 (fr) * | 2003-11-27 | 2005-06-09 | Fidia Advanced Biopolymers S.R.L. | Structures composites contenant de l'acide hyaluronique et ses derives utilisables, nouveaux substituts osseux et materiaux de greffes osseuses |
US20060040894A1 (en) * | 2004-08-13 | 2006-02-23 | Angiotech International Ag | Compositions and methods using hyaluronic acid |
WO2007009477A1 (fr) * | 2005-07-21 | 2007-01-25 | Lisopharm Ag | Procede de production de particules d'hydroxyapatite, notamment de particules d'hydroxyapatite sous-nanodispersees dans une matrice |
FR2938187A1 (fr) * | 2008-11-07 | 2010-05-14 | Anteis Sa | Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur |
WO2010136694A2 (fr) * | 2009-05-26 | 2010-12-02 | Anteis S.A. | Hydrogel injectable permettant une supplementation en glycerol dans la peau sur le long terme |
WO2012080915A1 (fr) * | 2010-12-17 | 2012-06-21 | Anteis S.A. | Formulation aqueuse injectable stérile utilisée en ophtalmologie |
WO2013053457A1 (fr) * | 2011-10-12 | 2013-04-18 | Regenyal Laboratories S.R.L. | Synthèse d'un gel multiphasique injectable contenant de l'acide hyaluronique monophasique libre et réticulé et de l'acide hyaluronique biphasique en association avec de l'hydroxyapatite et un inhibiteur de l'hyaluronidase microencapsulé |
Non-Patent Citations (1)
Title |
---|
MALAFAYA ET AL: "Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER BV, AMSTERDAM, NL, vol. 59, no. 4-5, 9 June 2007 (2007-06-09), pages 207 - 233, XP022110905, ISSN: 0169-409X, DOI: 10.1016/J.ADDR.2007.03.012 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2712641C2 (ru) * | 2014-11-13 | 2020-01-30 | Мерц Фарма Гмбх Унд Ко. Кгаа | Дермальный филлер на основе поперечносшитой гиалуроновой кислоты и карбоксиметилцеллюлозы в качестве лубриканта |
US10335512B2 (en) | 2014-11-13 | 2019-07-02 | Merz Pharma Gmbh & Co. Kgaa | Dermal filler based on crosslinked hyaluronic acid and carboxymethyl cellulose lubricant |
WO2016074794A1 (fr) * | 2014-11-13 | 2016-05-19 | Merz Pharma Gmbh & Co. Kgaa | Charge dermique à base d'acide hyaluronique réticulé et de lubrifiant de carboxyméthylcellulose |
EP3354258A1 (fr) | 2017-01-31 | 2018-08-01 | Teoxane SA | Utilisation d'un gel cohésif en tant que matériau de matrice dans une poche parodontale |
WO2019135729A1 (fr) * | 2018-01-03 | 2019-07-11 | Светлана Александровна ЛАРКИНА | Composition pour injections esthétiques |
US11000489B2 (en) | 2018-03-19 | 2021-05-11 | Bryn Pharma, LLC | Epinephrine spray formulations |
US10688044B2 (en) | 2018-03-19 | 2020-06-23 | Bryn Pharma, LLC | Epinephrine spray formulations |
US10925841B2 (en) | 2018-03-19 | 2021-02-23 | Bryn Pharma, LLC | Epinephrine spray formulations |
US11723884B2 (en) | 2018-03-19 | 2023-08-15 | Bryn Pharma, LLC | Epinephrine spray formulations |
WO2019197608A1 (fr) | 2018-04-13 | 2019-10-17 | Merz Pharma Gmbh & Co. Kgaa | Charge dermique à base d'acide hyaluronique réticulé, de particules de matière de phosphate de calcium et de carboxyméthylcellulose, son procédé de préparation et ses utilisations |
US11672750B2 (en) | 2018-04-13 | 2023-06-13 | Merz Pharma Gmbh & Co. Kgaa | Dermal filler based on crosslinked hyaluronic acid, calcium phosphate material particles and carboxymethyl cellulose, a process for preparing same and uses thereof |
WO2020095079A1 (fr) * | 2018-11-06 | 2020-05-14 | Kylane Laboratoires Sa | Composition injectable contenant de l'acide hyaluronique pour des applications au niveau du corps |
WO2021156345A1 (fr) * | 2020-02-06 | 2021-08-12 | Merz Pharma Gmbh & Co. Kgaa | Composition injectable pour l'augmentation de la peau et des tissus mous |
Also Published As
Publication number | Publication date |
---|---|
BR112015007746A2 (pt) | 2017-07-04 |
JP2015531280A (ja) | 2015-11-02 |
ES2595252T3 (es) | 2016-12-28 |
EP2903591A1 (fr) | 2015-08-12 |
CA2885884A1 (fr) | 2014-04-17 |
CN104853742A (zh) | 2015-08-19 |
AR092934A1 (es) | 2015-05-06 |
CN104853742B (zh) | 2018-11-30 |
TW201427697A (zh) | 2014-07-16 |
EP2903591B1 (fr) | 2016-07-06 |
MX2015004165A (es) | 2015-10-14 |
RU2018134453A (ru) | 2019-05-24 |
JP6476120B2 (ja) | 2019-02-27 |
RU2015109085A (ru) | 2016-11-27 |
US20150238525A1 (en) | 2015-08-27 |
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