WO2014026965A1 - Tierfutter- oder tränkwasserzusatz für wiederkäuer - Google Patents

Tierfutter- oder tränkwasserzusatz für wiederkäuer Download PDF

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Publication number
WO2014026965A1
WO2014026965A1 PCT/EP2013/066872 EP2013066872W WO2014026965A1 WO 2014026965 A1 WO2014026965 A1 WO 2014026965A1 EP 2013066872 W EP2013066872 W EP 2013066872W WO 2014026965 A1 WO2014026965 A1 WO 2014026965A1
Authority
WO
WIPO (PCT)
Prior art keywords
animal feed
animal
pine
bark
ground
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2013/066872
Other languages
German (de)
English (en)
French (fr)
Inventor
Klaus Neufeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP13748310.3A priority Critical patent/EP2884987B1/de
Priority to AU2013304114A priority patent/AU2013304114B2/en
Priority to JP2015526959A priority patent/JP6169177B2/ja
Priority to CN201380043152.3A priority patent/CN104661667B/zh
Priority to KR1020157006493A priority patent/KR20150041663A/ko
Publication of WO2014026965A1 publication Critical patent/WO2014026965A1/de
Anticipated expiration legal-status Critical
Priority to US14/624,027 priority patent/US20150208692A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • monensin is produced by Streptomyces cinnamonensis. In the context of the widespread earlier use of monensin in ruminants, it has been demonstrated that monensin also has a positive effect on the prevalence of ruminal acidosis via an influence on the activity of the rumen flora.
  • Ruminant farm animals such as cows, sheep or goats, have two large ones
  • an animal feed additive which contains a lignocellulose-containing, iron ion-binding material such as wood, wood fibers, bark or
  • pine bark, elm bark or extracts thereof exhibit a mechanism of action which is triggered (i.e., triggered) by a decrease in pH (i.e., an acidity increase).
  • the oligomeric procyanidins contained in the pine and elm bark are released and thus active by a drop in the pH in the area sensitive to the development of rumen acidosis or subacute rumen acidosis. The amount released and the
  • Animal feed or potable water can be treated, reduced or avoided, are pH reduction in the rumen, derangement of the rumen flora, cessation of
  • the use of the feed additive according to the invention also leads to a reduced aflatoxin excretion in the milk of ruminants.
  • This reduction in the excretion of aflatoxin is associated with the significantly reduced acidosis frequency as a result of the use of the feed additive according to the invention.
  • the feed additive according to the invention generally causes a better rumen activity, which also leads to a degradation of aflatoxins.
  • Alfalfa silage (Alfalfa silage), by-products (e.g., brewer's grains).
  • the animal feed additive containing oligomeric procyanidines may be administered mixed with the animal feed (for example forage, milk feed, concentrated feed, etc.), or it may be added on top to the respective feed rations.
  • the invention in another aspect, relates to a premix for the preparation of an animal feed, the premix comprising the animal feed additive containing oligomeric procyanidins for the treatment or prophylaxis of acute or subacute
  • the invention also relates to the use of an inventive
  • Procyanidines are present as an iron-containing complex.
  • bark is preferably ground and the powder thus obtained is dissolved in a percolator with 0.1 molar hydrochloric acid solution
  • Example 1 / n-wfroTests with oliqomeren Procvanidinen
  • Mechanism of action characterized by a drop in pH (i.e.
  • Acid increase is conditional.
  • Extensive research has shown that the pine bark oligomeric procyanidins are released and thus become active by an increase in acidity (ie pH drop) to a region in which the development of (subacute) rumen acidosis is to be expected.
  • the amount released and the Release rates may be affected by the degree of extraction of the bark.
  • the animals were fed a diet of concentrated feed, maize silage and hay, the concentrate being equal parts of barley, wheat and soy HP (i.e. high protein soybean meal).
  • the composition of the feed is shown in Table 4 below.
  • the animal feed of the animal feed according to the invention was mixed on-top.
  • the feed supplement containing oligomeric procyanidins was fed in the case of the test diet in two different dosages (15 g per animal per day and 30 g per animal per day, respectively).
  • Protein content of the milk is an indicator of the energy supply of the animal.
  • the two parameters are to be assessed together as urea / protein and are divided into nine classes.
  • the value should be in the middle field (class 5).
  • Metabolism control energy supply with inventive animal feed supplement Around 73% of the animals were in the "normal” range, only 17% of the animals in the “energy exceeded” range.
  • Example 5 Animal feed according to the invention for dairy cows

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
PCT/EP2013/066872 2012-08-14 2013-08-13 Tierfutter- oder tränkwasserzusatz für wiederkäuer Ceased WO2014026965A1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP13748310.3A EP2884987B1 (de) 2012-08-14 2013-08-13 Tierfutter- oder tränkwasserzusatz für wiederkäuer
AU2013304114A AU2013304114B2 (en) 2012-08-14 2013-08-13 Additive for animal food or drinking water for ruminants
JP2015526959A JP6169177B2 (ja) 2012-08-14 2013-08-13 反芻動物用の動物飼料添加剤または飲料水添加剤
CN201380043152.3A CN104661667B (zh) 2012-08-14 2013-08-13 用于反刍动物的动物饲料添加剂或者饮用水添加剂
KR1020157006493A KR20150041663A (ko) 2012-08-14 2013-08-13 반추동물용 동물 사료 또는 식수용 첨가제
US14/624,027 US20150208692A1 (en) 2012-08-14 2015-02-17 Additive for animal food or drinking water for ruminants

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT8882012 2012-08-14
ATA888/2012 2012-08-14
ATA904/2012 2012-08-20
ATA904/2012A AT513228B1 (de) 2012-08-14 2012-08-20 Tierfutter- oder Tränkwasserzusatz für Wiederkäuer

Publications (1)

Publication Number Publication Date
WO2014026965A1 true WO2014026965A1 (de) 2014-02-20

Family

ID=48985753

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Application Number Title Priority Date Filing Date
PCT/EP2013/066872 Ceased WO2014026965A1 (de) 2012-08-14 2013-08-13 Tierfutter- oder tränkwasserzusatz für wiederkäuer

Country Status (8)

Country Link
US (1) US20150208692A1 (enExample)
EP (1) EP2884987B1 (enExample)
JP (1) JP6169177B2 (enExample)
KR (1) KR20150041663A (enExample)
CN (1) CN104661667B (enExample)
AT (1) AT513228B1 (enExample)
AU (1) AU2013304114B2 (enExample)
WO (1) WO2014026965A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105192312A (zh) * 2015-09-18 2015-12-30 河北农业大学 一种猪用饲料添加剂及其制备方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108464396A (zh) * 2017-02-23 2018-08-31 尼娜·诺伊费尔德 用于群体感应抑制的来自木材的动物饲料添加剂
CN107927365A (zh) * 2017-11-30 2018-04-20 隆安县江泉牧业有限公司 作物秸秆预处理方法及其在制备氨化饲料中的应用
CN107927342A (zh) * 2017-11-30 2018-04-20 隆安县江泉牧业有限公司 氨化粗饲料功能性添加剂及其应用
CN107950767A (zh) * 2017-11-30 2018-04-24 隆安县江泉牧业有限公司 杂交肉牛用氨化粗饲料及其制备方法
CN107889943A (zh) * 2017-11-30 2018-04-10 隆安县江泉牧业有限公司 秸秆浸渍液及其制备方法和应用
CN107950766A (zh) * 2017-11-30 2018-04-24 隆安县江泉牧业有限公司 新型抗病氨化饲料的制备方法
CN110897047A (zh) * 2019-10-25 2020-03-24 广西泓尚科技有限责任公司 一种含有糖蜜的饲料添加剂的制备及其干燥方法
EP4023812A1 (de) * 2020-12-29 2022-07-06 MM BOARD & PAPER GmbH Verfahren zur herstellung von produkten auf basis von holz als rohstoff
CN117397752A (zh) * 2023-10-16 2024-01-16 中国科学院东北地理与农业生态研究所农业技术中心 一种改善反刍家畜瘤胃淀粉酶活性的方法
CN120189456B (zh) * 2025-05-26 2025-08-08 东北农业大学 一种提高犊牛生长性能的支链脂肪酸制剂及其制备方法

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CN101474344A (zh) * 2009-01-21 2009-07-08 中国农业科学院兰州畜牧与兽药研究所 羊用行气燥湿健脾的药物
EP2085083A1 (en) * 2008-01-09 2009-08-05 Exquim S.A. Mixture of citric flavonoids to improve ruminal fermentation
WO2011127499A1 (de) * 2010-04-15 2011-10-20 Klaus Neufeld Tierfutterzusatz mit antimikrobieller und leistungsfördernder wirkung
WO2012002871A1 (en) * 2010-07-01 2012-01-05 Perstorp Ab Mycotoxin binding compositions

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JP4064487B2 (ja) * 1997-02-15 2008-03-19 太陽化学株式会社 家畜用予防剤及び治療剤
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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
EP2085083A1 (en) * 2008-01-09 2009-08-05 Exquim S.A. Mixture of citric flavonoids to improve ruminal fermentation
CN101474344A (zh) * 2009-01-21 2009-07-08 中国农业科学院兰州畜牧与兽药研究所 羊用行气燥湿健脾的药物
WO2011127499A1 (de) * 2010-04-15 2011-10-20 Klaus Neufeld Tierfutterzusatz mit antimikrobieller und leistungsfördernder wirkung
WO2012002871A1 (en) * 2010-07-01 2012-01-05 Perstorp Ab Mycotoxin binding compositions

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DATABASE WPI Week 200967, Derwent World Patents Index; AN 2009-L64723, XP002713124 *
LEIBETSEDER J ET AL: "Crude fiber dietary fiber", KRAFTFUTTER - FEED MAGAZINE, FRANKFURT, DE, vol. 89, no. 10, 1 January 2006 (2006-01-01), pages 24 - 28, XP008089625, ISSN: 0023-4427 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105192312A (zh) * 2015-09-18 2015-12-30 河北农业大学 一种猪用饲料添加剂及其制备方法

Also Published As

Publication number Publication date
JP2015526082A (ja) 2015-09-10
AU2013304114A1 (en) 2015-04-02
AU2013304114B2 (en) 2016-11-17
EP2884987B1 (de) 2019-02-27
AT513228A1 (de) 2014-02-15
AT513228B1 (de) 2016-05-15
US20150208692A1 (en) 2015-07-30
JP6169177B2 (ja) 2017-07-26
EP2884987A1 (de) 2015-06-24
KR20150041663A (ko) 2015-04-16
CN104661667B (zh) 2023-10-13
CN104661667A (zh) 2015-05-27

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